RNF214

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.62638749
2central nervous system myelination (GO:0022010)7.62638749
3presynaptic membrane assembly (GO:0097105)5.71068393
4presynaptic membrane organization (GO:0097090)5.10755158
5fatty acid elongation (GO:0030497)5.00498706
6neuronal action potential propagation (GO:0019227)4.69157696
7myelination (GO:0042552)4.50980825
8long-chain fatty acid biosynthetic process (GO:0042759)4.48339050
9axon ensheathment (GO:0008366)4.45739068
10ensheathment of neurons (GO:0007272)4.45739068
11neuron cell-cell adhesion (GO:0007158)4.27648153
12postsynaptic membrane organization (GO:0001941)4.21653177
13behavioral response to nicotine (GO:0035095)4.19775356
14eye photoreceptor cell differentiation (GO:0001754)3.99076331
15photoreceptor cell differentiation (GO:0046530)3.99076331
16negative regulation of neurotransmitter secretion (GO:0046929)3.94473600
17regulation of meiosis I (GO:0060631)3.89911722
18limb bud formation (GO:0060174)3.88821387
19negative regulation of neurotransmitter transport (GO:0051589)3.76676312
20glycerophospholipid catabolic process (GO:0046475)3.73319453
21cerebral cortex radially oriented cell migration (GO:0021799)3.73012997
22regulation of pigment cell differentiation (GO:0050932)3.62202140
23positive regulation of cellular amine metabolic process (GO:0033240)3.59283060
24transmission of nerve impulse (GO:0019226)3.58857861
25resolution of meiotic recombination intermediates (GO:0000712)3.58779490
26regulation of collateral sprouting (GO:0048670)3.58417999
27GPI anchor biosynthetic process (GO:0006506)3.53962093
28L-amino acid import (GO:0043092)3.53794713
29nonmotile primary cilium assembly (GO:0035058)3.53748754
30oligodendrocyte differentiation (GO:0048709)3.52892390
31centriole replication (GO:0007099)3.51751418
32positive regulation of action potential (GO:0045760)3.48023615
33cholesterol biosynthetic process (GO:0006695)3.47276152
34GPI anchor metabolic process (GO:0006505)3.45845194
35cranial nerve morphogenesis (GO:0021602)3.45457646
36negative regulation of protein localization to cell surface (GO:2000009)3.33320469
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.33138901
38adult walking behavior (GO:0007628)3.32529035
39substrate-independent telencephalic tangential migration (GO:0021826)3.31981220
40substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.31981220
41synapsis (GO:0007129)3.30775926
42mannosylation (GO:0097502)3.30566302
43negative regulation of execution phase of apoptosis (GO:1900118)3.24512488
44neuron remodeling (GO:0016322)3.20535427
45negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.11121670
46intraciliary transport (GO:0042073)3.10862842
47response to redox state (GO:0051775)3.04646570
48developmental pigmentation (GO:0048066)3.03589371
49chromatin remodeling at centromere (GO:0031055)3.02965257
50magnesium ion transport (GO:0015693)3.02387511
51sterol biosynthetic process (GO:0016126)2.98879057
52isoprenoid biosynthetic process (GO:0008299)2.98474588
53histone H2B ubiquitination (GO:0033523)2.97681552
54C-terminal protein lipidation (GO:0006501)2.93948953
55astrocyte development (GO:0014002)2.93490757
56replication fork processing (GO:0031297)2.93082977
57somite development (GO:0061053)2.91394079
58chaperone-mediated protein transport (GO:0072321)2.90453056
59neuronal ion channel clustering (GO:0045161)2.89005015
60single strand break repair (GO:0000012)2.87857605
61CENP-A containing nucleosome assembly (GO:0034080)2.87207920
62preassembly of GPI anchor in ER membrane (GO:0016254)2.85979222
63negative regulation of transcription by competitive promoter binding (GO:0010944)2.84779321
64piRNA metabolic process (GO:0034587)2.84717980
65establishment of mitochondrion localization (GO:0051654)2.83339946
66protein localization to synapse (GO:0035418)2.82067322
67protein polyglutamylation (GO:0018095)2.81494342
68gamma-aminobutyric acid signaling pathway (GO:0007214)2.81455462
69chromosome organization involved in meiosis (GO:0070192)2.80500857
70regulation of nuclear cell cycle DNA replication (GO:0033262)2.80484556
71righting reflex (GO:0060013)2.79772048
72membrane assembly (GO:0071709)2.78030339
73male meiosis (GO:0007140)2.77653865
74cranial nerve development (GO:0021545)2.77218082
75myelination in peripheral nervous system (GO:0022011)2.76072387
76peripheral nervous system axon ensheathment (GO:0032292)2.76072387
77dendritic spine morphogenesis (GO:0060997)2.75409440
78chaperone-mediated protein complex assembly (GO:0051131)2.75409195
79response to methylmercury (GO:0051597)2.74859238
80histone exchange (GO:0043486)2.74308995
81retinal ganglion cell axon guidance (GO:0031290)2.73353211
82import into cell (GO:0098657)2.73084791
83pyrimidine nucleobase catabolic process (GO:0006208)2.71138437
84C-terminal protein amino acid modification (GO:0018410)2.70921027
85positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.69732703
86positive regulation of meiotic cell cycle (GO:0051446)2.69418325
87epithelial cilium movement (GO:0003351)2.69051263
88positive regulation of synapse assembly (GO:0051965)2.67951145
89negative regulation of axonogenesis (GO:0050771)2.67543724
90establishment of protein localization to Golgi (GO:0072600)2.67374994
91DNA double-strand break processing (GO:0000729)2.66797549
92ionotropic glutamate receptor signaling pathway (GO:0035235)2.65221540
93ribosomal small subunit assembly (GO:0000028)2.64997405
94DNA methylation involved in gamete generation (GO:0043046)2.63073980
95negative regulation of axon extension (GO:0030517)2.62716110
96hindbrain development (GO:0030902)2.62502855
97cellular response to epinephrine stimulus (GO:0071872)2.61841111
98neurotransmitter catabolic process (GO:0042135)2.61632679
99nucleotide transmembrane transport (GO:1901679)2.60327446
100otic vesicle formation (GO:0030916)2.59923965
101auditory behavior (GO:0031223)2.59906750
102sympathetic nervous system development (GO:0048485)2.59397471
103central nervous system neuron axonogenesis (GO:0021955)2.58969000
104central nervous system projection neuron axonogenesis (GO:0021952)2.58951098
105protein targeting to Golgi (GO:0000042)2.58907432
106male meiosis I (GO:0007141)2.58534692
107mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58392232
108axonal fasciculation (GO:0007413)2.57921200
109substantia nigra development (GO:0021762)2.57677975
110protein palmitoylation (GO:0018345)2.57226178
111regulation of cilium movement (GO:0003352)2.56045871
112mechanosensory behavior (GO:0007638)2.55950749
113generation of neurons (GO:0048699)2.55623950
114appendage development (GO:0048736)2.55282299
115limb development (GO:0060173)2.55282299
116amino acid import (GO:0043090)2.54824110
117histone H2A acetylation (GO:0043968)2.53848949
118meiotic chromosome segregation (GO:0045132)2.53265211
119reciprocal meiotic recombination (GO:0007131)2.52476731
120reciprocal DNA recombination (GO:0035825)2.52476731
121axon development (GO:0061564)2.51870934
122sex differentiation (GO:0007548)2.51627141
123organ growth (GO:0035265)2.51463311
124negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50060284
125glycolipid biosynthetic process (GO:0009247)2.49685226
126synaptic transmission, glutamatergic (GO:0035249)2.49585550
127lymphoid progenitor cell differentiation (GO:0002320)2.49475122
128peripheral nervous system development (GO:0007422)2.48873027
129regulation of feeding behavior (GO:0060259)2.48801401
130nucleoside diphosphate catabolic process (GO:0009134)2.48788278
131neuron recognition (GO:0008038)2.48204054
132response to epinephrine (GO:0071871)2.47851361
133glutamate receptor signaling pathway (GO:0007215)2.47380044
134regulation of DNA endoreduplication (GO:0032875)2.46934643
135cilium morphogenesis (GO:0060271)2.46929861
136neurotransmitter uptake (GO:0001504)2.46786861
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46556227
138cerebellar granule cell differentiation (GO:0021707)2.46136086
139DNA replication-independent nucleosome assembly (GO:0006336)2.45901625
140DNA replication-independent nucleosome organization (GO:0034724)2.45901625
141retina layer formation (GO:0010842)2.43155152
142pituitary gland development (GO:0021983)2.42753660
143retrograde transport, vesicle recycling within Golgi (GO:0000301)2.42532798
144positive regulation of meiosis (GO:0045836)2.42344653
145regulation of action potential (GO:0098900)2.41728968
146meiosis I (GO:0007127)2.41496831
147enteric nervous system development (GO:0048484)2.41373693
148mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.40362605
149cell proliferation in forebrain (GO:0021846)2.40326506
150spinal cord motor neuron differentiation (GO:0021522)2.39682607
151protein complex biogenesis (GO:0070271)2.39233333
152neuron-neuron synaptic transmission (GO:0007270)2.39188451
153neuronal action potential (GO:0019228)2.38815324
154positive regulation of membrane potential (GO:0045838)2.38474357
155dendrite development (GO:0016358)2.37991488
156regulation of activation of Janus kinase activity (GO:0010533)2.37825693
157protein-cofactor linkage (GO:0018065)2.35459350
158synaptonemal complex organization (GO:0070193)2.35296617
159olfactory bulb development (GO:0021772)2.34759414
160viral transcription (GO:0019083)2.34533572
161establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.34482595
162mitochondrion transport along microtubule (GO:0047497)2.34482595
163regulation of mitotic spindle checkpoint (GO:1903504)2.32898470
164regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.32898470
165spermatid nucleus differentiation (GO:0007289)2.32474345
166regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.32194377
167synaptonemal complex assembly (GO:0007130)2.32024224
168translational termination (GO:0006415)2.31348523
169kinetochore organization (GO:0051383)2.30742591
170protein neddylation (GO:0045116)2.29777309
171protein localization to Golgi apparatus (GO:0034067)2.28925494
172positive regulation of gastrulation (GO:2000543)2.28675638
173cardiac right ventricle morphogenesis (GO:0003215)2.27310779
174mitochondrial respiratory chain complex I assembly (GO:0032981)2.27260367
175NADH dehydrogenase complex assembly (GO:0010257)2.27260367
176mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.27260367
177RNA localization (GO:0006403)2.27074240
178somatic hypermutation of immunoglobulin genes (GO:0016446)2.26970962
179somatic diversification of immune receptors via somatic mutation (GO:0002566)2.26970962
180epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.25505365
181negative regulation of DNA-dependent DNA replication (GO:2000104)2.25364803
182mitotic sister chromatid cohesion (GO:0007064)2.22923090
183spinal cord development (GO:0021510)2.22447911
184mitochondrial respiratory chain complex assembly (GO:0033108)2.22214134
185cilium assembly (GO:0042384)2.22064574
186centriole assembly (GO:0098534)2.21859081
187nucleobase catabolic process (GO:0046113)2.21281240
188seminiferous tubule development (GO:0072520)2.21187377
189regulation of microtubule-based movement (GO:0060632)2.20880201
190cilium organization (GO:0044782)2.20445031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.14296815
2GBX2_23144817_ChIP-Seq_PC3_Human4.05983615
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.02350458
4ZNF274_21170338_ChIP-Seq_K562_Hela2.76251833
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76230628
6TAF15_26573619_Chip-Seq_HEK293_Human2.61232888
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52451110
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.46633155
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46391553
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43165799
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35361819
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29555453
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19300740
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.13959875
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13461076
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13461076
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.12351867
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10736964
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.10538928
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.08776167
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07810291
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06765385
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05774148
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05561620
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.04501189
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03810381
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98932058
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97578952
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95223173
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90290871
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85781958
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.85158056
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85063143
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83461998
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82341070
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.81367268
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81262524
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80896570
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80521916
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79576010
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75410188
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73596127
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71352886
44AR_21572438_ChIP-Seq_LNCaP_Human1.71347173
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71093907
46P300_19829295_ChIP-Seq_ESCs_Human1.70058423
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.69843921
48FUS_26573619_Chip-Seq_HEK293_Human1.66792598
49ER_23166858_ChIP-Seq_MCF-7_Human1.64141111
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62545522
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62507340
52RNF2_27304074_Chip-Seq_NSC_Mouse1.61941614
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61147251
54ELK1_19687146_ChIP-ChIP_HELA_Human1.60034221
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60014894
56* SMAD3_21741376_ChIP-Seq_EPCs_Human1.57088477
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.56624402
58VDR_22108803_ChIP-Seq_LS180_Human1.56354375
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55441060
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53610170
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50728932
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50540597
63REST_21632747_ChIP-Seq_MESCs_Mouse1.50272884
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50089774
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.48993637
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46985998
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46534839
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44939378
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42089682
70MYC_18940864_ChIP-ChIP_HL60_Human1.40280309
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.40063490
72SMAD4_21799915_ChIP-Seq_A2780_Human1.39900736
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.37682068
74P53_22387025_ChIP-Seq_ESCs_Mouse1.37481339
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37221598
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36995949
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36536326
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36085720
79P300_18555785_Chip-Seq_ESCs_Mouse1.36064095
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.35976795
81IGF1R_20145208_ChIP-Seq_DFB_Human1.34700925
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33914029
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32514954
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32112156
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.32059612
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.31902182
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.31728980
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.31265809
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29956947
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29538679
91DROSHA_22980978_ChIP-Seq_HELA_Human1.28673142
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.28230106
93RUNX1_27457419_Chip-Seq_LIVER_Mouse1.28079255
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27210055
95CBP_20019798_ChIP-Seq_JUKART_Human1.27084055
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27084055
97* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26006715
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.24373820
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.23202735
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22001210
101AR_25329375_ChIP-Seq_VCAP_Human1.21844124
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21756781
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21320597
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.20425977
105STAT3_23295773_ChIP-Seq_U87_Human1.19089924
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18493174
107BCAT_22108803_ChIP-Seq_LS180_Human1.17747683
108* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17557094
109RUNX2_22187159_ChIP-Seq_PCA_Human1.15780138
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14813053
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14813053
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14813053
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14603055
114TCF4_23295773_ChIP-Seq_U87_Human1.14112928
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13836168
116ETS1_20019798_ChIP-Seq_JURKAT_Human1.13712091
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12854320
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.12811570
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.12649093
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12258769
121SOX9_26525672_Chip-Seq_HEART_Mouse1.08664633
122VDR_23849224_ChIP-Seq_CD4+_Human1.08382462
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07819149
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07095152
125SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06546307
126EWS_26573619_Chip-Seq_HEK293_Human1.06430093
127PU1_27457419_Chip-Seq_LIVER_Mouse1.05884505
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05867851
129KDM2B_26808549_Chip-Seq_REH_Human1.05496405
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04720555
131REST_18959480_ChIP-ChIP_MESCs_Mouse1.04344519
132IRF1_19129219_ChIP-ChIP_H3396_Human1.04265944
133TP53_22573176_ChIP-Seq_HFKS_Human1.03934677
134ZFX_18555785_Chip-Seq_ESCs_Mouse1.03325218
135CTCF_18555785_Chip-Seq_ESCs_Mouse1.02815876
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02746428
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01355652
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.00962079
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00957545
140HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00328239
141NANOG_16153702_ChIP-ChIP_HESCs_Human0.99458254
142FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99285217
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99035940
144* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98789084
145TTF2_22483619_ChIP-Seq_HELA_Human0.95716511
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94312390
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93281684
148NOTCH1_21737748_ChIP-Seq_TLL_Human0.93173361
149* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92620226
150FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91681337
151FOXP3_21729870_ChIP-Seq_TREG_Human0.90552323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.76182226
2MP0005409_darkened_coat_color3.78918479
3MP0008877_abnormal_DNA_methylation3.70503805
4MP0001188_hyperpigmentation3.27753022
5MP0003136_yellow_coat_color3.13640314
6MP0005423_abnormal_somatic_nervous2.92868150
7MP0000920_abnormal_myelination2.81776336
8MP0003890_abnormal_embryonic-extraembry2.79823730
9MP0004270_analgesia2.75156560
10MP0006292_abnormal_olfactory_placode2.72131842
11MP0001486_abnormal_startle_reflex2.52700688
12MP0003787_abnormal_imprinting2.50892064
13MP0002272_abnormal_nervous_system2.44000462
14MP0009379_abnormal_foot_pigmentation2.32093249
15MP0004859_abnormal_synaptic_plasticity2.24430807
16MP0001905_abnormal_dopamine_level2.21540588
17MP0004742_abnormal_vestibular_system2.20828220
18MP0001529_abnormal_vocalization2.16350807
19MP0009745_abnormal_behavioral_response2.10353737
20MP0003635_abnormal_synaptic_transmissio2.09723927
21MP0004381_abnormal_hair_follicle2.07684524
22MP0002102_abnormal_ear_morphology2.02518255
23MP0002064_seizures2.01107070
24MP0003121_genomic_imprinting2.00745163
25MP0002734_abnormal_mechanical_nocicepti1.99941980
26MP0009046_muscle_twitch1.98722552
27MP0000778_abnormal_nervous_system1.95713894
28MP0002653_abnormal_ependyma_morphology1.93956245
29MP0003122_maternal_imprinting1.92517751
30MP0001293_anophthalmia1.91553952
31MP0005171_absent_coat_pigmentation1.90602545
32MP0004133_heterotaxia1.86635865
33MP0001986_abnormal_taste_sensitivity1.83183979
34MP0008058_abnormal_DNA_repair1.81475126
35MP0002163_abnormal_gland_morphology1.80962235
36MP0004142_abnormal_muscle_tone1.80556042
37MP0006276_abnormal_autonomic_nervous1.79158749
38MP0001968_abnormal_touch/_nociception1.73790854
39MP0005551_abnormal_eye_electrophysiolog1.72441425
40MP0001485_abnormal_pinna_reflex1.69213024
41MP0002572_abnormal_emotion/affect_behav1.66005847
42MP0002067_abnormal_sensory_capabilities1.65168579
43MP0000015_abnormal_ear_pigmentation1.63701515
44MP0000569_abnormal_digit_pigmentation1.61715855
45MP0000372_irregular_coat_pigmentation1.59829717
46MP0008789_abnormal_olfactory_epithelium1.54202829
47MP0002229_neurodegeneration1.53064102
48MP0008995_early_reproductive_senescence1.48900118
49MP0003283_abnormal_digestive_organ1.48853937
50MP0005646_abnormal_pituitary_gland1.47478455
51MP0005394_taste/olfaction_phenotype1.46504992
52MP0005499_abnormal_olfactory_system1.46504992
53MP0004885_abnormal_endolymph1.45679146
54MP0003938_abnormal_ear_development1.44570977
55MP0008569_lethality_at_weaning1.43782200
56MP0002210_abnormal_sex_determination1.42840249
57MP0002063_abnormal_learning/memory/cond1.42289044
58MP0005379_endocrine/exocrine_gland_phen1.40971448
59MP0005174_abnormal_tail_pigmentation1.40740222
60MP0003690_abnormal_glial_cell1.40407819
61MP0001970_abnormal_pain_threshold1.40271076
62MP0001440_abnormal_grooming_behavior1.39139860
63MP0001963_abnormal_hearing_physiology1.37582701
64MP0002735_abnormal_chemical_nociception1.36959638
65MP0002837_dystrophic_cardiac_calcinosis1.36276863
66MP0000631_abnormal_neuroendocrine_gland1.35749553
67MP0002882_abnormal_neuron_morphology1.34392972
68MP0002733_abnormal_thermal_nociception1.32951396
69MP0001929_abnormal_gametogenesis1.32453637
70MP0006072_abnormal_retinal_apoptosis1.31433391
71MP0002752_abnormal_somatic_nervous1.30959350
72MP0003567_abnormal_fetal_cardiomyocyte1.29875531
73MP0002736_abnormal_nociception_after1.28633478
74MP0002184_abnormal_innervation1.28421481
75MP0000566_synostosis1.27696812
76MP0008260_abnormal_autophagy1.27641017
77MP0003698_abnormal_male_reproductive1.26925843
78MP0004924_abnormal_behavior1.26075468
79MP0005386_behavior/neurological_phenoty1.26075468
80MP0002557_abnormal_social/conspecific_i1.25810222
81MP0001502_abnormal_circadian_rhythm1.25652110
82MP0000026_abnormal_inner_ear1.23277984
83MP0003646_muscle_fatigue1.21293679
84MP0003634_abnormal_glial_cell1.19851092
85MP0000955_abnormal_spinal_cord1.19798358
86MP0002751_abnormal_autonomic_nervous1.19548230
87MP0003119_abnormal_digestive_system1.19375008
88MP0003861_abnormal_nervous_system1.18330861
89MP0002233_abnormal_nose_morphology1.17688229
90MP0010030_abnormal_orbit_morphology1.17182942
91MP0001286_abnormal_eye_development1.15369216
92MP0001145_abnormal_male_reproductive1.13868956
93MP0000653_abnormal_sex_gland1.09876276
94MP0005084_abnormal_gallbladder_morpholo1.08861102
95MP0005645_abnormal_hypothalamus_physiol1.06764210
96MP0002938_white_spotting1.05629932
97MP0005075_abnormal_melanosome_morpholog1.05126293
98MP0002876_abnormal_thyroid_physiology1.04691254
99MP0002638_abnormal_pupillary_reflex1.03473073
100MP0002066_abnormal_motor_capabilities/c1.03051926
101MP0004957_abnormal_blastocyst_morpholog1.02593307
102MP0001501_abnormal_sleep_pattern1.02486518
103MP0002177_abnormal_outer_ear1.02331974
104MP0000462_abnormal_digestive_system1.00558673
105MP0003632_abnormal_nervous_system1.00035685
106MP0005253_abnormal_eye_physiology1.00015530
107MP0003693_abnormal_embryo_hatching0.99251477
108MP0005410_abnormal_fertilization0.99183882
109MP0003755_abnormal_palate_morphology0.97473304
110MP0002084_abnormal_developmental_patter0.97416797
111MP0000647_abnormal_sebaceous_gland0.97385749
112MP0000049_abnormal_middle_ear0.97238643
113MP0002697_abnormal_eye_size0.95872768
114MP0002234_abnormal_pharynx_morphology0.95339806
115MP0003718_maternal_effect0.94998886
116MP0010386_abnormal_urinary_bladder0.94143540
117MP0004145_abnormal_muscle_electrophysio0.93597194
118MP0005451_abnormal_body_composition0.92745085
119MP0002928_abnormal_bile_duct0.92469723
120MP0000579_abnormal_nail_morphology0.91750440
121MP0001984_abnormal_olfaction0.91500564
122MP0001346_abnormal_lacrimal_gland0.89517780
123MP0001919_abnormal_reproductive_system0.89321318
124MP0003329_amyloid_beta_deposits0.87864471
125MP0004134_abnormal_chest_morphology0.87671019
126MP0003942_abnormal_urinary_system0.86953756
127MP0005195_abnormal_posterior_eye0.86635162
128MP0010094_abnormal_chromosome_stability0.85351462
129MP0003631_nervous_system_phenotype0.85010664
130MP0003879_abnormal_hair_cell0.84502699
131MP0002822_catalepsy0.84224686
132MP0004147_increased_porphyrin_level0.83110806
133MP0005389_reproductive_system_phenotype0.82646496
134MP0008932_abnormal_embryonic_tissue0.82389004
135MP0002249_abnormal_larynx_morphology0.81436582
136MP0002095_abnormal_skin_pigmentation0.80816508
137MP0005391_vision/eye_phenotype0.80183190
138MP0000613_abnormal_salivary_gland0.79401507
139MP0000681_abnormal_thyroid_gland0.78558183
140MP0003633_abnormal_nervous_system0.78464273
141MP0003724_increased_susceptibility_to0.78355183
142MP0002152_abnormal_brain_morphology0.77812210
143MP0003950_abnormal_plasma_membrane0.76855459
144MP0009250_abnormal_appendicular_skeleto0.74500085
145MP0003937_abnormal_limbs/digits/tail_de0.73501564
146MP0001664_abnormal_digestion0.72016258
147MP0000383_abnormal_hair_follicle0.71439503

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.41809801
2Degeneration of the lateral corticospinal tracts (HP:0002314)3.68899810
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.68899810
4Molar tooth sign on MRI (HP:0002419)3.47477224
5Abnormality of midbrain morphology (HP:0002418)3.47477224
6Focal motor seizures (HP:0011153)3.27293205
7Hypothermia (HP:0002045)3.23178088
8Nephronophthisis (HP:0000090)3.21609018
9Sensory axonal neuropathy (HP:0003390)3.17271390
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.12899272
11Renal Fanconi syndrome (HP:0001994)3.12066492
12Type I transferrin isoform profile (HP:0003642)3.07319474
13Neurofibrillary tangles (HP:0002185)3.03922395
14Abnormality of the labia minora (HP:0012880)3.01194340
15Peripheral hypomyelination (HP:0007182)2.97249086
16Type II lissencephaly (HP:0007260)2.90792770
17Volvulus (HP:0002580)2.83314367
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.80941594
19Absent/shortened dynein arms (HP:0200106)2.80941594
20Absent septum pellucidum (HP:0001331)2.79110107
21Pancreatic fibrosis (HP:0100732)2.77362477
22Reduced antithrombin III activity (HP:0001976)2.74392442
23Abnormality of the corticospinal tract (HP:0002492)2.73957920
24Split foot (HP:0001839)2.70374578
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66535415
26Nonprogressive disorder (HP:0003680)2.66262979
27Duplicated collecting system (HP:0000081)2.63645340
28Increased hepatocellular lipid droplets (HP:0006565)2.63517422
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58620988
30Reticulocytopenia (HP:0001896)2.58145080
31Abnormality of the renal medulla (HP:0100957)2.56635450
32Decreased central vision (HP:0007663)2.55060572
33Abnormality of the renal collecting system (HP:0004742)2.53723145
34Thyroid-stimulating hormone excess (HP:0002925)2.53092287
35Akinesia (HP:0002304)2.52973294
36Retinal dysplasia (HP:0007973)2.52683041
37Concave nail (HP:0001598)2.44824924
38Septo-optic dysplasia (HP:0100842)2.42890137
39Abnormality of the septum pellucidum (HP:0007375)2.41450811
40Oligodactyly (hands) (HP:0001180)2.38818263
41Scanning speech (HP:0002168)2.37247342
42Patchy hypopigmentation of hair (HP:0011365)2.31002872
43Broad-based gait (HP:0002136)2.31000739
44Gaze-evoked nystagmus (HP:0000640)2.30971542
45Epileptic encephalopathy (HP:0200134)2.30129841
46Abnormal ciliary motility (HP:0012262)2.29687056
47Abnormality of abdominal situs (HP:0011620)2.27138841
48Abdominal situs inversus (HP:0003363)2.27138841
49Febrile seizures (HP:0002373)2.27103269
50Pancreatic cysts (HP:0001737)2.26667778
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25547601
52Anomalous pulmonary venous return (HP:0010772)2.25476427
53Rhabdomyosarcoma (HP:0002859)2.25098605
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23892557
55Abnormal protein N-linked glycosylation (HP:0012347)2.23892557
56Abnormal protein glycosylation (HP:0012346)2.23892557
57Abnormal glycosylation (HP:0012345)2.23892557
58Abnormal number of incisors (HP:0011064)2.22104839
59Abnormality of secondary sexual hair (HP:0009888)2.21768299
60Abnormality of the axillary hair (HP:0100134)2.21768299
61Acute encephalopathy (HP:0006846)2.21337734
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21304594
63White forelock (HP:0002211)2.21088765
64Medial flaring of the eyebrow (HP:0010747)2.19528085
65Dysmetria (HP:0001310)2.19516108
66Rib fusion (HP:0000902)2.17633266
67Abnormality of magnesium homeostasis (HP:0004921)2.17353959
68Abnormal respiratory motile cilium physiology (HP:0012261)2.15120303
69Intestinal atresia (HP:0011100)2.15042519
70Hypomagnesemia (HP:0002917)2.14616861
71Optic nerve hypoplasia (HP:0000609)2.12785945
72Flat occiput (HP:0005469)2.11967723
73Abnormality of renal resorption (HP:0011038)2.11083975
74Narrow forehead (HP:0000341)2.10627157
75Action tremor (HP:0002345)2.10184587
76Limb hypertonia (HP:0002509)2.09965200
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09869960
78Lipid accumulation in hepatocytes (HP:0006561)2.09345993
79Spastic gait (HP:0002064)2.08852045
80Abnormality of the parathyroid morphology (HP:0011766)2.06400301
81Progressive macrocephaly (HP:0004481)2.05686610
82Optic disc pallor (HP:0000543)2.05101838
83Abnormal hair whorl (HP:0010721)2.04673191
84Atonic seizures (HP:0010819)2.03591623
85Cupped ear (HP:0000378)2.03455880
86Gait imbalance (HP:0002141)2.03396036
87Vaginal atresia (HP:0000148)2.03382887
88Hypoplastic pelvis (HP:0008839)2.03016813
89Attenuation of retinal blood vessels (HP:0007843)2.02902629
903-Methylglutaconic aciduria (HP:0003535)2.02267582
91Genital tract atresia (HP:0001827)2.01886238
92Congenital sensorineural hearing impairment (HP:0008527)2.01875525
93Impulsivity (HP:0100710)2.01294721
94Abnormal mitochondria in muscle tissue (HP:0008316)2.00948042
95Adrenal hypoplasia (HP:0000835)2.00733376
96Progressive inability to walk (HP:0002505)2.00460689
97Horseshoe kidney (HP:0000085)1.99575370
98Lissencephaly (HP:0001339)1.98550312
99True hermaphroditism (HP:0010459)1.98346178
100Abnormal respiratory motile cilium morphology (HP:0005938)1.97521619
101Abnormal respiratory epithelium morphology (HP:0012253)1.97521619
102Abolished electroretinogram (ERG) (HP:0000550)1.97419822
103Cerebellar dysplasia (HP:0007033)1.96870904
104Acute necrotizing encephalopathy (HP:0006965)1.96706820
105Keratoconus (HP:0000563)1.95176430
106Increased corneal curvature (HP:0100692)1.95176430
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94488954
108Genetic anticipation (HP:0003743)1.94400593
109Slow saccadic eye movements (HP:0000514)1.92913990
110Alacrima (HP:0000522)1.92193052
111Congenital ichthyosiform erythroderma (HP:0007431)1.92024839
112Bifid tongue (HP:0010297)1.90836999
113Drooling (HP:0002307)1.89918248
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.89487767
115Anencephaly (HP:0002323)1.89160914
116Mitochondrial inheritance (HP:0001427)1.89125936
117Anophthalmia (HP:0000528)1.88947103
118Duplication of thumb phalanx (HP:0009942)1.88947088
119Oligodactyly (HP:0012165)1.88142009
120Methylmalonic acidemia (HP:0002912)1.88028564
121Progressive cerebellar ataxia (HP:0002073)1.87206381
122Preaxial hand polydactyly (HP:0001177)1.85329702
123Sclerocornea (HP:0000647)1.84888236
124Ectopic kidney (HP:0000086)1.84044756
125Cortical visual impairment (HP:0100704)1.83600994
126Abnormality of the pulmonary veins (HP:0011718)1.83464597
127Neoplasm of striated muscle (HP:0009728)1.82844919
128Thickened helices (HP:0000391)1.82191472
129Hepatocellular necrosis (HP:0001404)1.81924080
130Nephrogenic diabetes insipidus (HP:0009806)1.81280224
131Supranuclear gaze palsy (HP:0000605)1.80533011
132Esotropia (HP:0000565)1.79964888
133Nasolacrimal duct obstruction (HP:0000579)1.79748825
134Increased serum pyruvate (HP:0003542)1.79007924
135Abnormality of glycolysis (HP:0004366)1.79007924
136Small hand (HP:0200055)1.78510799
137Intention tremor (HP:0002080)1.78240271
138Congenital primary aphakia (HP:0007707)1.77832454
139Myokymia (HP:0002411)1.77364051
140Hyperglycinemia (HP:0002154)1.76482062
141Triphalangeal thumb (HP:0001199)1.75993999
142Male pseudohermaphroditism (HP:0000037)1.75911202
143Leukodystrophy (HP:0002415)1.75736710
144Prominent nasal bridge (HP:0000426)1.75588106
145Postaxial hand polydactyly (HP:0001162)1.74452392
146Onion bulb formation (HP:0003383)1.73917874
147Cystic liver disease (HP:0006706)1.73591275
148Highly arched eyebrow (HP:0002553)1.73181908
149Stenosis of the external auditory canal (HP:0000402)1.73177077
150Pachygyria (HP:0001302)1.72355144
151Congenital malformation of the right heart (HP:0011723)1.72006569
152Double outlet right ventricle (HP:0001719)1.72006569
153Renal hypoplasia (HP:0000089)1.70766943
154Degeneration of anterior horn cells (HP:0002398)1.70096208
155Abnormality of the anterior horn cell (HP:0006802)1.70096208
156Dandy-Walker malformation (HP:0001305)1.69076031
157Meckel diverticulum (HP:0002245)1.68773223
158Chronic hepatic failure (HP:0100626)1.68070229
159Hypoplasia of the pons (HP:0012110)1.67670384
160Chromsome breakage (HP:0040012)1.67507559
161Abnormality of DNA repair (HP:0003254)1.66831634
162Poor coordination (HP:0002370)1.65694600
163Abnormality of the incisor (HP:0000676)1.65541742
164Colon cancer (HP:0003003)1.65000016
165Abnormality of the pons (HP:0007361)1.64795740
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.64364065
167Abnormal rod and cone electroretinograms (HP:0008323)1.64350161
168Postaxial foot polydactyly (HP:0001830)1.63755652
169Excessive salivation (HP:0003781)1.63627236
170Aganglionic megacolon (HP:0002251)1.63536449
171Hypoplastic iliac wings (HP:0002866)1.62764063
172Barrel-shaped chest (HP:0001552)1.62404584
173Anterior segment dysgenesis (HP:0007700)1.62289450
174Abnormality of the ileum (HP:0001549)1.60944097
175Severe visual impairment (HP:0001141)1.60096697
176Holoprosencephaly (HP:0001360)1.59373171
177Pendular nystagmus (HP:0012043)1.59335913
178Bilateral microphthalmos (HP:0007633)1.58753571
179Abnormality of chromosome stability (HP:0003220)1.58623339
180Aplasia/Hypoplasia of the sternum (HP:0006714)1.58049413
181Gastrointestinal atresia (HP:0002589)1.57121551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.56200020
2STK394.07156312
3CASK3.77763968
4MUSK2.86037136
5OXSR12.85439391
6CAMK1G2.36558704
7WNK32.25284025
8EIF2AK32.10474154
9PRPF4B2.00411841
10MKNK21.99910588
11MARK11.95028020
12STK161.88487955
13MAPK131.86480706
14CDK191.85756566
15EPHB11.81214201
16NEK61.79551430
17CDC71.77227387
18MAP2K71.75105288
19PKN11.74302516
20CAMK1D1.70699923
21PLK41.69532994
22MAPKAPK51.60712261
23NTRK31.60038250
24WNK41.60005845
25MKNK11.55438363
26BCR1.54104672
27UHMK11.53335212
28BMPR1B1.52571225
29FES1.45907128
30VRK21.39795770
31FRK1.32469507
32PAK31.31551906
33CSNK1G31.31114496
34DYRK31.28648610
35NLK1.27397028
36IRAK21.26493964
37TRIM281.25679121
38IRAK41.23884380
39CSNK1G11.23786658
40KSR11.20775809
41PBK1.19171572
42CSNK1A1L1.17446896
43BRD41.14627310
44EPHA41.12489091
45PLK31.11802817
46DYRK21.10837920
47GRK71.06076884
48CAMKK21.05111161
49EIF2AK21.04458857
50WEE11.04339999
51NME11.02409561
52CDK31.01143712
53CSNK1G20.98712347
54CLK10.98688801
55TAOK30.97136686
56PLK10.96908591
57ADRBK20.96585177
58PLK20.96187806
59IRAK10.95911094
60WNK10.94882484
61BLK0.93592280
62PASK0.91727186
63EPHB20.90371842
64VRK10.90095375
65ACVR1B0.89983050
66CAMK2B0.89874096
67DMPK0.89322439
68TTK0.89041562
69MST40.87188383
70NTRK20.82214420
71SRPK10.80922100
72MAP3K90.79980474
73PRKD30.79950120
74GRK10.78702413
75NTRK10.77885439
76SGK2230.77390563
77SGK4940.77390563
78CAMK2A0.76226355
79LATS10.75461214
80CDK50.75293568
81ATM0.74754659
82FGR0.74604716
83TLK10.74531408
84YES10.74376988
85MAPK150.74048596
86TSSK60.73278919
87CAMK2D0.71671895
88MARK30.71326990
89CAMK10.70898355
90BRSK20.70768049
91PRKCE0.70080642
92CHEK10.70045149
93CCNB10.69902257
94CSNK1E0.68640163
95MET0.68181402
96SGK20.66771164
97ROCK20.66205715
98NEK20.65994954
99BMPR20.65044373
100MARK20.62092501
101MAP2K40.61760234
102PNCK0.61581590
103INSRR0.58673157
104EIF2AK10.57427856
105AURKA0.56505011
106CHEK20.56319138
107BRSK10.56295579
108STK30.56212736
109NUAK10.54801911
110MAP3K40.53182871
111PTK2B0.52819735
112TEC0.52522774
113ATR0.52351715
114PHKG20.51814156
115PHKG10.51814156
116PAK60.51132966
117PRKCQ0.49690177
118PRKCI0.49522960
119OBSCN0.48970094
120DYRK1A0.48643668
121PRKG10.48408936
122PRKD20.48257922
123PIK3CA0.47386881
124SGK10.43747597
125CDK10.43268251
126SIK20.42361969
127ERBB40.41734996
128CDK20.41648261
129STK38L0.41289254
130TGFBR10.41276219
131CAMK40.41192806
132CAMK2G0.40013096
133TNK20.39898279
134MAP3K120.39404402
135CDK140.39206376
136TAF10.38989955
137PRKDC0.38609091
138FGFR10.37987344
139LIMK10.37637047
140STK110.37601174
141FYN0.37408510
142PRKACA0.37084598
143FGFR20.34174504
144ZAK0.33337241
145PINK10.32382359
146PRKCG0.32307507
147CSNK1A10.31792430
148CDK150.31457547
149CDK180.30633796
150KIT0.30533843
151CDK11A0.30416212
152HIPK20.29721652
153MAPK40.29473699
154GRK50.28949634
155RPS6KA50.28263555
156MINK10.27135838

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.96492399
2Steroid biosynthesis_Homo sapiens_hsa001003.62056533
3Fatty acid elongation_Homo sapiens_hsa000623.11912913
4Ribosome_Homo sapiens_hsa030102.95110872
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85490336
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.79835695
7Ether lipid metabolism_Homo sapiens_hsa005652.68060369
8Nicotine addiction_Homo sapiens_hsa050332.52585733
9Mismatch repair_Homo sapiens_hsa034302.42389570
10Oxidative phosphorylation_Homo sapiens_hsa001902.41871730
11Protein export_Homo sapiens_hsa030602.41164810
12Phototransduction_Homo sapiens_hsa047442.18202055
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99246825
14Propanoate metabolism_Homo sapiens_hsa006401.98075801
15Homologous recombination_Homo sapiens_hsa034401.97453126
16Serotonergic synapse_Homo sapiens_hsa047261.91530203
17Sphingolipid metabolism_Homo sapiens_hsa006001.86117684
18Glutamatergic synapse_Homo sapiens_hsa047241.85070132
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80997773
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80373658
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78357825
22RNA degradation_Homo sapiens_hsa030181.76434719
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.75142533
24Axon guidance_Homo sapiens_hsa043601.74958474
25RNA transport_Homo sapiens_hsa030131.73804547
26Morphine addiction_Homo sapiens_hsa050321.66962640
27GABAergic synapse_Homo sapiens_hsa047271.66138686
28Parkinsons disease_Homo sapiens_hsa050121.64321621
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63250173
30Spliceosome_Homo sapiens_hsa030401.61877734
31Alzheimers disease_Homo sapiens_hsa050101.60635464
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52533418
33Hedgehog signaling pathway_Homo sapiens_hsa043401.46842577
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46805604
35Linoleic acid metabolism_Homo sapiens_hsa005911.44171879
36Basal cell carcinoma_Homo sapiens_hsa052171.40978779
37Long-term depression_Homo sapiens_hsa047301.37133557
38Nucleotide excision repair_Homo sapiens_hsa034201.36410062
39Circadian entrainment_Homo sapiens_hsa047131.35276932
40Taste transduction_Homo sapiens_hsa047421.33234286
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27047728
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23811296
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21800201
44mRNA surveillance pathway_Homo sapiens_hsa030151.20441350
45Arachidonic acid metabolism_Homo sapiens_hsa005901.19249550
46Base excision repair_Homo sapiens_hsa034101.19136055
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17916360
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17720941
49Cell cycle_Homo sapiens_hsa041101.14875101
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11818559
51Cholinergic synapse_Homo sapiens_hsa047251.11043164
52Huntingtons disease_Homo sapiens_hsa050161.10442709
53DNA replication_Homo sapiens_hsa030301.02416311
54Synaptic vesicle cycle_Homo sapiens_hsa047211.01136427
55Collecting duct acid secretion_Homo sapiens_hsa049660.98110268
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98088997
57Histidine metabolism_Homo sapiens_hsa003400.97223925
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95195190
59Dopaminergic synapse_Homo sapiens_hsa047280.94939465
60Cardiac muscle contraction_Homo sapiens_hsa042600.94453419
61Salivary secretion_Homo sapiens_hsa049700.94443571
62Basal transcription factors_Homo sapiens_hsa030220.93927949
63Calcium signaling pathway_Homo sapiens_hsa040200.88940980
64Cocaine addiction_Homo sapiens_hsa050300.88051568
65Autoimmune thyroid disease_Homo sapiens_hsa053200.87692738
66Oocyte meiosis_Homo sapiens_hsa041140.87406400
67Ovarian steroidogenesis_Homo sapiens_hsa049130.87292916
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87099224
69Amphetamine addiction_Homo sapiens_hsa050310.86635952
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86587454
71Regulation of autophagy_Homo sapiens_hsa041400.86188399
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.86167848
73Butanoate metabolism_Homo sapiens_hsa006500.83319606
74Olfactory transduction_Homo sapiens_hsa047400.80850913
75Asthma_Homo sapiens_hsa053100.79979844
76Folate biosynthesis_Homo sapiens_hsa007900.79482919
77Rheumatoid arthritis_Homo sapiens_hsa053230.79192924
78Ras signaling pathway_Homo sapiens_hsa040140.75387726
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74586977
80Notch signaling pathway_Homo sapiens_hsa043300.74567888
81Hippo signaling pathway_Homo sapiens_hsa043900.74157370
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73359149
83RNA polymerase_Homo sapiens_hsa030200.73279780
84Insulin secretion_Homo sapiens_hsa049110.72658563
85Renin secretion_Homo sapiens_hsa049240.72518239
86Non-homologous end-joining_Homo sapiens_hsa034500.71871502
87Fanconi anemia pathway_Homo sapiens_hsa034600.69029656
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.68436480
89Pyrimidine metabolism_Homo sapiens_hsa002400.66256863
90TGF-beta signaling pathway_Homo sapiens_hsa043500.64663914
91Peroxisome_Homo sapiens_hsa041460.63936707
92cAMP signaling pathway_Homo sapiens_hsa040240.62402318
93Long-term potentiation_Homo sapiens_hsa047200.61861227
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60878699
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60866012
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60414440
97Pyruvate metabolism_Homo sapiens_hsa006200.59106573
98Vibrio cholerae infection_Homo sapiens_hsa051100.59007091
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.58714652
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55954577
101p53 signaling pathway_Homo sapiens_hsa041150.55141743
102Lysine degradation_Homo sapiens_hsa003100.54418625
103Sulfur metabolism_Homo sapiens_hsa009200.54031967
104Arginine and proline metabolism_Homo sapiens_hsa003300.51812212
105ErbB signaling pathway_Homo sapiens_hsa040120.51415676
106Selenocompound metabolism_Homo sapiens_hsa004500.50852082
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.50740675
108Gastric acid secretion_Homo sapiens_hsa049710.48610917
109One carbon pool by folate_Homo sapiens_hsa006700.48085990
110Fatty acid metabolism_Homo sapiens_hsa012120.47598218
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47441112
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.47426804
113Pancreatic secretion_Homo sapiens_hsa049720.47141962
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47076024
115Oxytocin signaling pathway_Homo sapiens_hsa049210.46934018
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46817292
117Wnt signaling pathway_Homo sapiens_hsa043100.45933888
118Colorectal cancer_Homo sapiens_hsa052100.45080598
119Metabolic pathways_Homo sapiens_hsa011000.44033331
120Fat digestion and absorption_Homo sapiens_hsa049750.43507610
121Adherens junction_Homo sapiens_hsa045200.43338296
122Tight junction_Homo sapiens_hsa045300.43112232
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40978510
124Proteasome_Homo sapiens_hsa030500.40718801
125Other glycan degradation_Homo sapiens_hsa005110.40258731
126Melanogenesis_Homo sapiens_hsa049160.38940947
127Gap junction_Homo sapiens_hsa045400.38138258
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37373428
129GnRH signaling pathway_Homo sapiens_hsa049120.36880092
130Choline metabolism in cancer_Homo sapiens_hsa052310.36438327
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36383327
132Retinol metabolism_Homo sapiens_hsa008300.35982032
133Circadian rhythm_Homo sapiens_hsa047100.35856000
134Allograft rejection_Homo sapiens_hsa053300.35532624
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.35265384
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33965140
137N-Glycan biosynthesis_Homo sapiens_hsa005100.33924339
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33886348
139Phagosome_Homo sapiens_hsa041450.33850452
140Purine metabolism_Homo sapiens_hsa002300.33839498
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33736748
142Dorso-ventral axis formation_Homo sapiens_hsa043200.33618098
143Alcoholism_Homo sapiens_hsa050340.33513843
144ABC transporters_Homo sapiens_hsa020100.32738775
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32521665
146Tryptophan metabolism_Homo sapiens_hsa003800.30960094

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