RNF187

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.10901533
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82844889
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.67601191
4synaptic vesicle exocytosis (GO:0016079)5.38943842
5locomotory exploration behavior (GO:0035641)5.33573298
6layer formation in cerebral cortex (GO:0021819)5.22308811
7regulation of synaptic vesicle exocytosis (GO:2000300)5.08704557
8vocalization behavior (GO:0071625)5.06955684
9negative regulation of microtubule polymerization (GO:0031115)5.04760177
10glutamate secretion (GO:0014047)4.91678405
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.89732777
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.82340113
13regulation of synapse structural plasticity (GO:0051823)4.80351764
14protein localization to synapse (GO:0035418)4.64848203
15exploration behavior (GO:0035640)4.52947492
16regulation of synaptic vesicle transport (GO:1902803)4.52768392
17cerebellar granule cell differentiation (GO:0021707)4.51237237
18regulation of glutamate receptor signaling pathway (GO:1900449)4.46491903
19neurotransmitter secretion (GO:0007269)4.37942843
20positive regulation of synapse maturation (GO:0090129)4.35680390
21dendritic spine morphogenesis (GO:0060997)4.27244711
22neuron cell-cell adhesion (GO:0007158)4.24162970
23cell migration in hindbrain (GO:0021535)4.15486749
24sodium ion export (GO:0071436)4.12700343
25regulation of neuronal synaptic plasticity (GO:0048168)4.09483970
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.09161010
27cytoskeletal anchoring at plasma membrane (GO:0007016)4.09068711
28response to pheromone (GO:0019236)4.05393889
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97368239
30activation of protein kinase A activity (GO:0034199)3.90745701
31neuronal action potential propagation (GO:0019227)3.83004245
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.77305662
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.75876831
34cellular potassium ion homeostasis (GO:0030007)3.71203498
35pyrimidine nucleobase catabolic process (GO:0006208)3.68728263
36cell communication by electrical coupling (GO:0010644)3.60803046
37neuron recognition (GO:0008038)3.59683600
38regulation of early endosome to late endosome transport (GO:2000641)3.56664919
39cerebellar Purkinje cell layer development (GO:0021680)3.54337718
40protein retention in ER lumen (GO:0006621)3.51771033
41regulation of ARF protein signal transduction (GO:0032012)3.48801600
42synaptic transmission, glutamatergic (GO:0035249)3.47625611
43proline biosynthetic process (GO:0006561)3.46825134
44neuromuscular process controlling balance (GO:0050885)3.46420983
45proline transport (GO:0015824)3.40760375
46regulation of mammary gland epithelial cell proliferation (GO:0033599)3.40712672
47neurotransmitter transport (GO:0006836)3.40260868
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36343824
49positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.36152458
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.35437897
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35222367
52protein localization to endosome (GO:0036010)3.35170710
53regulation of vesicle fusion (GO:0031338)3.34783300
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33502332
55dendrite morphogenesis (GO:0048813)3.31587677
56positive regulation of membrane potential (GO:0045838)3.31355624
57glutamate receptor signaling pathway (GO:0007215)3.30105939
58neuromuscular process controlling posture (GO:0050884)3.29673233
59prepulse inhibition (GO:0060134)3.28496980
60maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27279686
61neuron-neuron synaptic transmission (GO:0007270)3.26850943
62axonal fasciculation (GO:0007413)3.26700837
63axon cargo transport (GO:0008088)3.25187068
64synaptic vesicle endocytosis (GO:0048488)3.24236448
65regulation of neurotransmitter levels (GO:0001505)3.23784590
66potassium ion homeostasis (GO:0055075)3.23051528
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21476435
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20693046
69positive regulation of dendritic spine development (GO:0060999)3.19471564
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18878499
71auditory behavior (GO:0031223)3.18263538
72long-term memory (GO:0007616)3.16030058
73regulation of dendritic spine morphogenesis (GO:0061001)3.14991169
74gamma-aminobutyric acid transport (GO:0015812)3.14670967
75establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.13548036
76mitochondrion transport along microtubule (GO:0047497)3.13548036
77mating behavior (GO:0007617)3.13407725
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.12761215
79amino acid import (GO:0043090)3.11266978
80regulation of translational fidelity (GO:0006450)3.10689026
81regulation of postsynaptic membrane potential (GO:0060078)3.10337028
82dopamine receptor signaling pathway (GO:0007212)3.10233361
83cerebellar Purkinje cell differentiation (GO:0021702)3.09916796
84COPI coating of Golgi vesicle (GO:0048205)3.06763192
85Golgi transport vesicle coating (GO:0048200)3.06763192
86regulation of neurotransmitter secretion (GO:0046928)3.05612310
87neurotransmitter-gated ion channel clustering (GO:0072578)3.04931683
88neuronal ion channel clustering (GO:0045161)3.03844344
89protein targeting to plasma membrane (GO:0072661)3.03332912
90regulation of synaptic plasticity (GO:0048167)3.00396692
91response to auditory stimulus (GO:0010996)2.99656247
92social behavior (GO:0035176)2.98390875
93intraspecies interaction between organisms (GO:0051703)2.98390875
94establishment of mitochondrion localization (GO:0051654)2.98286158
95membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97867809
96dendritic spine organization (GO:0097061)2.97625387
97regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.96142203
98transmission of nerve impulse (GO:0019226)2.94889071
99regulation of synapse maturation (GO:0090128)2.94500237
100membrane hyperpolarization (GO:0060081)2.92806550
101adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.92285331
102organelle transport along microtubule (GO:0072384)2.91317552
103positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.91195276
104regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.91195276
105nucleobase catabolic process (GO:0046113)2.90542633
106positive regulation of neurotransmitter secretion (GO:0001956)2.89202841
107adherens junction assembly (GO:0034333)2.88777559
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88165087
109clathrin coat assembly (GO:0048268)2.87090428
110membrane depolarization during action potential (GO:0086010)2.86600016
111peptidyl-arginine omega-N-methylation (GO:0035247)2.86353002
112response to parathyroid hormone (GO:0071107)2.84698024
113innervation (GO:0060384)2.83654373
114regulation of neurotransmitter transport (GO:0051588)2.83438278
115glycine transport (GO:0015816)2.83281230
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82710164
117positive regulation of neurotransmitter transport (GO:0051590)2.82423698
118central nervous system projection neuron axonogenesis (GO:0021952)2.82021334
119positive regulation of potassium ion transmembrane transport (GO:1901381)2.80460449
120negative regulation of cell size (GO:0045792)2.79686263
121synapse assembly (GO:0007416)2.78489293
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78159073
123maternal placenta development (GO:0001893)2.76225248
124cell-cell junction maintenance (GO:0045217)2.71439593
125L-amino acid import (GO:0043092)2.70277677
126focal adhesion assembly (GO:0048041)2.68939380
127cell-substrate adherens junction assembly (GO:0007045)2.68939380
128positive regulation of protein dephosphorylation (GO:0035307)2.67255149
129negative regulation of dendrite morphogenesis (GO:0050774)2.62402821
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60402449
131regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.57148741
132myelin maintenance (GO:0043217)2.56607528
133respiratory system process (GO:0003016)2.55033042
134proline metabolic process (GO:0006560)2.49268023
135regulation of glycogen (starch) synthase activity (GO:2000465)2.48740023
136regulation of protein dephosphorylation (GO:0035304)2.46774974
137peptidyl-tyrosine autophosphorylation (GO:0038083)2.45927469
138regulation of NFAT protein import into nucleus (GO:0051532)2.45466478
139negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44255702
140activation of Rac GTPase activity (GO:0032863)2.44238587
141postsynaptic membrane organization (GO:0001941)2.42708020
142regulation of glucose import in response to insulin stimulus (GO:2001273)2.42493833
143negative regulation of erythrocyte differentiation (GO:0045647)2.42190496
144potassium ion import (GO:0010107)2.42037961
145ribosomal small subunit biogenesis (GO:0042274)2.39279390
146cellular sodium ion homeostasis (GO:0006883)2.38903290
147negative regulation of catenin import into nucleus (GO:0035414)2.38716871
148activation of MAPKKK activity (GO:0000185)2.37829706
149glucose 6-phosphate metabolic process (GO:0051156)2.36986005
150semaphorin-plexin signaling pathway (GO:0071526)2.36894149
151mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.36560902
152dicarboxylic acid transport (GO:0006835)2.35957626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.21625863
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.13466073
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.04754447
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03135518
5REST_21632747_ChIP-Seq_MESCs_Mouse3.02665345
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.87836701
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.85336305
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84430773
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78400582
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.76398485
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75936592
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.69654271
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66241071
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66241071
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.60684585
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.54525469
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.54246829
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48733042
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46759890
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.46366992
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.42535770
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42321867
23DROSHA_22980978_ChIP-Seq_HELA_Human2.25779715
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24135468
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.24060609
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22387184
27RACK7_27058665_Chip-Seq_MCF-7_Human2.21632433
28ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.18532157
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.18148393
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16833101
31VDR_21846776_ChIP-Seq_THP-1_Human2.09375343
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.08595014
33DNAJC2_21179169_ChIP-ChIP_NT2_Human2.05671719
34RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03741918
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02789367
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.95204554
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.90531522
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86633195
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.85511779
40* LXR_22292898_ChIP-Seq_THP-1_Human1.85278698
41* KDM2B_26808549_Chip-Seq_K562_Human1.77715729
42ZNF274_21170338_ChIP-Seq_K562_Hela1.76822602
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.69776016
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.69711200
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67924671
46TCF7_22412390_ChIP-Seq_EML_Mouse1.64168381
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63633251
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.61921761
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58226174
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56577112
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55300015
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51767005
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.49737028
54GBX2_23144817_ChIP-Seq_PC3_Human1.49152853
55* KDM2B_26808549_Chip-Seq_DND41_Human1.47851467
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45961662
57* CTCF_27219007_Chip-Seq_Bcells_Human1.45123885
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43805366
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43279087
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42359388
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40516294
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39452867
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39255284
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37469596
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36255189
66ZNF263_19887448_ChIP-Seq_K562_Human1.35712381
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31064923
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30337930
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29157264
70* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29135787
71* TET1_21490601_ChIP-Seq_MESCs_Mouse1.27602430
72TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.27398823
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.25882082
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.24968306
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24124708
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23743501
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.21784116
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21086082
79SMC4_20622854_ChIP-Seq_HELA_Human1.20760501
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19663894
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18809020
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.18655001
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18330958
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17635625
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17217764
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16339340
87CLOCK_20551151_ChIP-Seq_293T_Human1.16240997
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15556154
89P68_20966046_ChIP-Seq_HELA_Human1.14234823
90XRN2_22483619_ChIP-Seq_HELA_Human1.13080796
91CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12581826
92* MYC_22102868_ChIP-Seq_BL_Human1.11507075
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11361251
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10829575
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10302393
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10093608
97* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08276930
98CREB1_26743006_Chip-Seq_LNCaP_Human1.06522944
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06454369
100IGF1R_20145208_ChIP-Seq_DFB_Human1.06351746
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06074328
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05830821
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04674966
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.03866278
105* ATF3_27146783_Chip-Seq_COLON_Human1.03808892
106* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03667114
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03608309
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03139959
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02534261
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02286227
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01994883
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.01906851
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01538379
114STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01284699
115TP53_22127205_ChIP-Seq_IMR90_Human0.99844470
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99753000
117* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98920866
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98651436
119* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98349455
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98306068
121AR_21572438_ChIP-Seq_LNCaP_Human0.98218354
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96858447
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96854269
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96366071
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94250877
126OCT4_19829295_ChIP-Seq_ESCs_Human0.94089691
127SOX3_22085726_ChIP-Seq_NPCs_Mouse0.93869446
128YY1_22570637_ChIP-Seq_MALME-3M_Human0.92065884
129AR_19668381_ChIP-Seq_PC3_Human0.90646363
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90281221
131FOXP1_21924763_ChIP-Seq_HESCs_Human0.89289027
132KLF4_19829295_ChIP-Seq_ESCs_Human0.88744497
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87168268
134SMAD4_21741376_ChIP-Seq_ESCs_Human0.85410928
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.85126057
136* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83926590
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82880099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.29620517
2MP0003880_abnormal_central_pattern4.14446475
3MP0003635_abnormal_synaptic_transmissio4.07470692
4MP0003705_abnormal_hypodermis_morpholog3.97865570
5MP0004270_analgesia3.48112765
6MP0002063_abnormal_learning/memory/cond3.18557008
7MP0009745_abnormal_behavioral_response2.99553944
8MP0005423_abnormal_somatic_nervous2.95604911
9MP0001968_abnormal_touch/_nociception2.86864650
10MP0002064_seizures2.84721938
11MP0009046_muscle_twitch2.52908817
12MP0002734_abnormal_mechanical_nocicepti2.49500297
13MP0002572_abnormal_emotion/affect_behav2.47377562
14MP0002733_abnormal_thermal_nociception2.35801349
15MP0003329_amyloid_beta_deposits2.31705698
16MP0002272_abnormal_nervous_system2.30344871
17MP0006276_abnormal_autonomic_nervous2.24522142
18MP0002736_abnormal_nociception_after2.21235977
19MP0002822_catalepsy2.20454681
20MP0002735_abnormal_chemical_nociception2.18966115
21MP0001486_abnormal_startle_reflex2.15943055
22MP0004811_abnormal_neuron_physiology2.14435989
23MP0002184_abnormal_innervation2.13549267
24MP0002909_abnormal_adrenal_gland2.07873726
25MP0001529_abnormal_vocalization2.07033162
26MP0004858_abnormal_nervous_system2.06211560
27MP0002249_abnormal_larynx_morphology2.05976918
28MP0001970_abnormal_pain_threshold2.05120890
29MP0000778_abnormal_nervous_system2.04107172
30MP0005451_abnormal_body_composition1.90089346
31MP0000955_abnormal_spinal_cord1.89439335
32MP0001440_abnormal_grooming_behavior1.87991520
33MP0010234_abnormal_vibrissa_follicle1.87776859
34MP0003122_maternal_imprinting1.83126305
35MP0008569_lethality_at_weaning1.80713945
36MP0005409_darkened_coat_color1.79747811
37MP0002067_abnormal_sensory_capabilities1.78699616
38MP0004924_abnormal_behavior1.76674354
39MP0005386_behavior/neurological_phenoty1.76674354
40MP0002557_abnormal_social/conspecific_i1.75387873
41MP0000751_myopathy1.73883570
42MP0000678_abnormal_parathyroid_gland1.73423492
43MP0008961_abnormal_basal_metabolism1.67397834
44MP0005058_abnormal_lysosome_morphology1.60922736
45MP0004185_abnormal_adipocyte_glucose1.60858980
46MP0009379_abnormal_foot_pigmentation1.58566101
47MP0002877_abnormal_melanocyte_morpholog1.56072483
48MP0002882_abnormal_neuron_morphology1.53927515
49MP0001346_abnormal_lacrimal_gland1.50417787
50MP0001849_ear_inflammation1.49544717
51MP0002066_abnormal_motor_capabilities/c1.47205991
52MP0001501_abnormal_sleep_pattern1.44057523
53MP0008260_abnormal_autophagy1.43736240
54MP0000579_abnormal_nail_morphology1.41194501
55MP0003879_abnormal_hair_cell1.39364555
56MP0004233_abnormal_muscle_weight1.38596227
57MP0004142_abnormal_muscle_tone1.35852333
58MP0002653_abnormal_ependyma_morphology1.34141505
59MP0005076_abnormal_cell_differentiation1.33983793
60MP0000566_synostosis1.33524385
61MP0002152_abnormal_brain_morphology1.32170710
62MP0001905_abnormal_dopamine_level1.28082030
63MP0008438_abnormal_cutaneous_collagen1.26776592
64MP0005645_abnormal_hypothalamus_physiol1.20739423
65MP0004885_abnormal_endolymph1.19172254
66MP0004145_abnormal_muscle_electrophysio1.18221998
67MP0003172_abnormal_lysosome_physiology1.18147100
68MP0001502_abnormal_circadian_rhythm1.15571859
69MP0001984_abnormal_olfaction1.14805832
70MP0002796_impaired_skin_barrier1.11155626
71MP0000920_abnormal_myelination1.11077158
72MP0003633_abnormal_nervous_system1.10657878
73MP0000003_abnormal_adipose_tissue1.10482911
74MP0003137_abnormal_impulse_conducting1.08606605
75MP0003690_abnormal_glial_cell1.06969432
76MP0002837_dystrophic_cardiac_calcinosis1.06392039
77MP0005501_abnormal_skin_physiology1.04825497
78MP0003942_abnormal_urinary_system1.04711243
79MP0009780_abnormal_chondrocyte_physiolo1.03860388
80MP0000681_abnormal_thyroid_gland1.03725241
81MP0003453_abnormal_keratinocyte_physiol1.03420966
82MP0008872_abnormal_physiological_respon1.01249743
83MP0003283_abnormal_digestive_organ1.00359387
84MP0001188_hyperpigmentation0.99867110
85MP0002089_abnormal_postnatal_growth/wei0.98819691
86MP0003861_abnormal_nervous_system0.98641264
87MP0001348_abnormal_lacrimal_gland0.98226982
88MP0005394_taste/olfaction_phenotype0.97894847
89MP0005499_abnormal_olfactory_system0.97894847
90MP0000733_abnormal_muscle_development0.96722570
91MP0002069_abnormal_eating/drinking_beha0.95765559
92MP0005666_abnormal_adipose_tissue0.95244845
93MP0003631_nervous_system_phenotype0.94129347
94MP0005187_abnormal_penis_morphology0.93865641
95MP0005375_adipose_tissue_phenotype0.92794869
96MP0000747_muscle_weakness0.92522398
97MP0000631_abnormal_neuroendocrine_gland0.92258631
98MP0004215_abnormal_myocardial_fiber0.92136373
99MP0000759_abnormal_skeletal_muscle0.91103503
100MP0002638_abnormal_pupillary_reflex0.88504652
101MP0000013_abnormal_adipose_tissue0.88210526
102MP0000604_amyloidosis0.88164963
103MP0002234_abnormal_pharynx_morphology0.88128036
104MP0002229_neurodegeneration0.86508203
105MP0002752_abnormal_somatic_nervous0.86379097
106MP0005257_abnormal_intraocular_pressure0.86095694
107MP0003123_paternal_imprinting0.85012499
108MP0004085_abnormal_heartbeat0.83501633
109MP0009672_abnormal_birth_weight0.83251115
110MP0003566_abnormal_cell_adhesion0.83173414
111MP0003634_abnormal_glial_cell0.82270338
112MP0010030_abnormal_orbit_morphology0.82241757
113MP0005646_abnormal_pituitary_gland0.80023501
114MP0000534_abnormal_ureter_morphology0.74350218
115MP0002751_abnormal_autonomic_nervous0.73586895
116MP0008874_decreased_physiological_sensi0.73257002
117MP0004742_abnormal_vestibular_system0.71956512
118MP0006072_abnormal_retinal_apoptosis0.70665315
119MP0000537_abnormal_urethra_morphology0.70578148
120MP0000750_abnormal_muscle_regeneration0.70303408
121MP0003646_muscle_fatigue0.70092744
122MP0003075_altered_response_to0.68568138
123MP0010769_abnormal_survival0.67452259
124MP0003938_abnormal_ear_development0.65868296
125MP0000762_abnormal_tongue_morphology0.65374856
126MP0009053_abnormal_anal_canal0.65098859
127MP0009840_abnormal_foam_cell0.64380070
128MP0001664_abnormal_digestion0.64314556
129MP0010768_mortality/aging0.63947293
130MP0003956_abnormal_body_size0.63866594
131MP0010770_preweaning_lethality0.63485440
132MP0002082_postnatal_lethality0.63485440
133MP0005551_abnormal_eye_electrophysiolog0.63374299
134MP0006035_abnormal_mitochondrial_morpho0.63192912
135MP0008770_decreased_survivor_rate0.63163080
136MP0003632_abnormal_nervous_system0.62550146
137MP0010386_abnormal_urinary_bladder0.61979507
138MP0001943_abnormal_respiration0.61978585
139MP0005535_abnormal_body_temperature0.61422048
140MP0005623_abnormal_meninges_morphology0.61414087
141MP0004087_abnormal_muscle_fiber0.61098869
142MP0002081_perinatal_lethality0.60836330
143MP0000462_abnormal_digestive_system0.60605605
144MP0002090_abnormal_vision0.60294998
145MP0004130_abnormal_muscle_cell0.60217367

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.46876504
2Visual hallucinations (HP:0002367)5.32582472
3Focal motor seizures (HP:0011153)4.75752693
4Focal seizures (HP:0007359)4.41339647
5Obstructive sleep apnea (HP:0002870)4.14842696
6Supranuclear gaze palsy (HP:0000605)3.91184403
7Ankle clonus (HP:0011448)3.83943901
8Insomnia (HP:0100785)3.43033705
9Depression (HP:0000716)3.40837522
10Abnormality of the lower motor neuron (HP:0002366)3.32458379
11Amyotrophic lateral sclerosis (HP:0007354)3.26167976
12Amblyopia (HP:0000646)3.23572903
13Epileptic encephalopathy (HP:0200134)3.22869636
14Mutism (HP:0002300)3.22046946
15Action tremor (HP:0002345)3.18475062
16Absence seizures (HP:0002121)3.16095590
17Limb dystonia (HP:0002451)3.10915605
18Poor eye contact (HP:0000817)3.05752758
19Urinary urgency (HP:0000012)3.02184132
20Progressive cerebellar ataxia (HP:0002073)2.95025318
21Pheochromocytoma (HP:0002666)2.87806637
22Papilledema (HP:0001085)2.87582279
23Atonic seizures (HP:0010819)2.81785737
24Anxiety (HP:0000739)2.80475569
25Truncal ataxia (HP:0002078)2.80383668
26Hyperacusis (HP:0010780)2.77922752
27Abnormal social behavior (HP:0012433)2.75334204
28Impaired social interactions (HP:0000735)2.75334204
29Large eyes (HP:0001090)2.75219515
30Dialeptic seizures (HP:0011146)2.74273950
31Impaired vibration sensation in the lower limbs (HP:0002166)2.72996330
32Generalized tonic-clonic seizures (HP:0002069)2.69850126
33Abnormal gallbladder physiology (HP:0012438)2.68730566
34Cholecystitis (HP:0001082)2.68730566
35Pointed chin (HP:0000307)2.67780688
36Abnormal eating behavior (HP:0100738)2.64823512
37Distal upper limb amyotrophy (HP:0007149)2.64516468
38Upper limb amyotrophy (HP:0009129)2.64516468
39Hyperthyroidism (HP:0000836)2.58501277
40Focal dystonia (HP:0004373)2.56653582
41Torticollis (HP:0000473)2.53788396
42Hyperparathyroidism (HP:0000843)2.52796029
43Megalencephaly (HP:0001355)2.52790401
44Neuroendocrine neoplasm (HP:0100634)2.49411496
45Cerebral inclusion bodies (HP:0100314)2.49138203
46Shallow orbits (HP:0000586)2.48404909
47Spastic gait (HP:0002064)2.48097708
48Diplopia (HP:0000651)2.47923653
49Abnormality of binocular vision (HP:0011514)2.47923653
50Protrusio acetabuli (HP:0003179)2.46868687
51Delusions (HP:0000746)2.46276687
52Insidious onset (HP:0003587)2.45706083
53Termporal pattern (HP:0011008)2.45706083
54Dysmetric saccades (HP:0000641)2.42402893
55Craniofacial dystonia (HP:0012179)2.39569739
56Aplasia/Hypoplasia of the brainstem (HP:0007362)2.38660796
57Hypoplasia of the brainstem (HP:0002365)2.38660796
58Hypoventilation (HP:0002791)2.37171830
59Reticulocytosis (HP:0001923)2.36141556
60Hypercortisolism (HP:0001578)2.35119163
61Turricephaly (HP:0000262)2.34593334
62Akinesia (HP:0002304)2.32749491
63Neoplasm of the peripheral nervous system (HP:0100007)2.32622536
64Failure to thrive in infancy (HP:0001531)2.32217476
65Febrile seizures (HP:0002373)2.32017073
66Long palpebral fissure (HP:0000637)2.31698210
67Urinary bladder sphincter dysfunction (HP:0002839)2.31584758
68Hand muscle atrophy (HP:0009130)2.30055761
69Agitation (HP:0000713)2.29996137
70Annular pancreas (HP:0001734)2.29520017
71Truncus arteriosus (HP:0001660)2.29150725
72Peripheral hypomyelination (HP:0007182)2.28221819
73Postural instability (HP:0002172)2.26630885
74Abnormality of the Achilles tendon (HP:0005109)2.26589171
75Apathy (HP:0000741)2.24725778
76Progressive inability to walk (HP:0002505)2.23495463
77Neoplasm of the heart (HP:0100544)2.22312801
78Bradykinesia (HP:0002067)2.21492306
79Polyphagia (HP:0002591)2.21392965
80Lissencephaly (HP:0001339)2.20807488
81Neurofibrillary tangles (HP:0002185)2.20683918
82Broad-based gait (HP:0002136)2.20626783
83Cerebral aneurysm (HP:0004944)2.20125309
84Rapidly progressive (HP:0003678)2.19685387
85Hemiparesis (HP:0001269)2.18541130
86Vertebral compression fractures (HP:0002953)2.17583272
87Dysdiadochokinesis (HP:0002075)2.17502550
88Bowel incontinence (HP:0002607)2.16393087
89Dysmetria (HP:0001310)2.16128521
90Diminished motivation (HP:0000745)2.16035830
91Lower limb amyotrophy (HP:0007210)2.13451355
92Elfin facies (HP:0004428)2.13014045
93Ventricular fibrillation (HP:0001663)2.12289407
94Overriding aorta (HP:0002623)2.10434543
95Foot dorsiflexor weakness (HP:0009027)2.10236332
96Centrally nucleated skeletal muscle fibers (HP:0003687)2.08589857
97Impaired smooth pursuit (HP:0007772)2.07109033
98Clonus (HP:0002169)2.05496466
99Premature rupture of membranes (HP:0001788)2.05381832
100Distal lower limb amyotrophy (HP:0008944)2.05123158
101Hammertoe (HP:0001765)2.03780593
102EEG with generalized epileptiform discharges (HP:0011198)2.02217392
103Myopathic facies (HP:0002058)2.01649333
104Ulnar bowing (HP:0003031)2.01518343
105Broad distal phalanx of finger (HP:0009836)1.99790925
106Shoulder girdle muscle weakness (HP:0003547)1.99783710
107Generalized hypotonia (HP:0001290)1.99661606
108Stereotypic behavior (HP:0000733)1.99622526
109Spinal cord compression (HP:0002176)1.99031431
110Abnormality of the corticospinal tract (HP:0002492)1.98551074
111Abnormal large intestine physiology (HP:0012700)1.98174430
112Hemiplegia (HP:0002301)1.97642984
113Disproportionate tall stature (HP:0001519)1.97318825
114Hypsarrhythmia (HP:0002521)1.96355219
115Epileptiform EEG discharges (HP:0011182)1.96059333
116Hypercalcemia (HP:0003072)1.93766873
117Patellar dislocation (HP:0002999)1.92077314
118Cholelithiasis (HP:0001081)1.91766709
119Type II lissencephaly (HP:0007260)1.91394269
120Distal sensory impairment (HP:0002936)1.90836150
121Stridor (HP:0010307)1.89909948
122Sleep apnea (HP:0010535)1.89652233
123Lower limb muscle weakness (HP:0007340)1.89376071
124Bladder diverticulum (HP:0000015)1.89355604
125Achilles tendon contracture (HP:0001771)1.88803723
126Increased variability in muscle fiber diameter (HP:0003557)1.88310872
127Ankyloglossia (HP:0010296)1.86856596
128Mitral regurgitation (HP:0001653)1.86743002
129Unsteady gait (HP:0002317)1.86620332
130Germ cell neoplasia (HP:0100728)1.86539589
131Neuronal loss in central nervous system (HP:0002529)1.86428211
132Distal lower limb muscle weakness (HP:0009053)1.84363909
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84297764
134Psychosis (HP:0000709)1.82141243
135Abnormality of ocular smooth pursuit (HP:0000617)1.81852708
136Precocious puberty (HP:0000826)1.81570916
137Poor suck (HP:0002033)1.81514169
138Sacral dimple (HP:0000960)1.80453032
139Atrophy/Degeneration involving motor neurons (HP:0007373)1.80233003
140Abnormality of the foot musculature (HP:0001436)1.80016176
141Tetraplegia (HP:0002445)1.78370476
142Scanning speech (HP:0002168)1.78173751
143Premature skin wrinkling (HP:0100678)1.77977854
144Intention tremor (HP:0002080)1.77028101
145Cerebral hypomyelination (HP:0006808)1.76112920
146Deep palmar crease (HP:0006191)1.75810286
147Excessive salivation (HP:0003781)1.75714289
148Drooling (HP:0002307)1.75714289
149Gaze-evoked nystagmus (HP:0000640)1.75557272
150Abnormality of reticulocytes (HP:0004312)1.74784982
151Rigidity (HP:0002063)1.74622982
152Renal duplication (HP:0000075)1.74524112
153Macroorchidism (HP:0000053)1.73987471
154Increased connective tissue (HP:0009025)1.71894853
155Back pain (HP:0003418)1.70418592
156Fragile skin (HP:0001030)1.70209177
157Decreased motor nerve conduction velocity (HP:0003431)1.70075006
158Genu recurvatum (HP:0002816)1.69840094
159Congenital glaucoma (HP:0001087)1.67331156
160Athetosis (HP:0002305)1.65476953
161Renovascular hypertension (HP:0100817)1.64969556
162Lower limb asymmetry (HP:0100559)1.64866846
163Aplasia involving bones of the extremities (HP:0009825)1.64325084
164Aplasia involving bones of the upper limbs (HP:0009823)1.64325084
165Aplasia of the phalanges of the hand (HP:0009802)1.64325084
166Atelectasis (HP:0100750)1.63249257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.12425721
2MARK13.86428539
3NTRK33.18105526
4MINK13.04519482
5PRPF4B3.01089880
6SMG12.99428656
7MAP3K42.74369770
8KSR22.72930366
9PAK62.51318943
10EPHA42.45378110
11KSR12.36598067
12SIK12.18214614
13CAMKK12.16152685
14NTRK22.11589773
15NTRK12.05315344
16PRKD32.00580534
17MAP2K71.92960714
18MAP3K121.91589519
19CDK191.82562462
20UHMK11.79517644
21DAPK21.68532237
22MAP2K41.67549989
23SCYL21.67499723
24IRAK31.60831210
25TRIB31.54695175
26SIK21.53870534
27LATS21.49056659
28TYRO31.46733118
29DAPK11.44028765
30CDK51.42356905
31MAPK131.40760690
32EEF2K1.35929514
33NEK11.34399933
34ERN11.32835247
35CDK121.29111786
36TAOK11.28672909
37PHKG21.27775152
38PHKG11.27775152
39CDK181.22010510
40PKN21.21563203
41BRAF1.21143536
42LIMK11.20865940
43CDK141.20216539
44ARAF1.19932921
45NME21.18944392
46CDK151.18627014
47PNCK1.12301599
48CDK11A1.09753904
49RET1.07683361
50TAOK21.06210896
51MAP3K21.02214028
52PRKD21.00861623
53RAF10.97534483
54CAMK1D0.95903505
55GRK50.95614070
56FES0.95052198
57ICK0.94210492
58LMTK20.92717392
59DYRK20.92408049
60MARK20.86575181
61EPHA20.85944348
62PAK30.85512121
63SIK30.85116943
64PRKCG0.84270475
65TESK20.84081042
66MTOR0.83578294
67STK380.81730500
68PTK20.80901252
69CAMKK20.79948103
70IRAK20.75955233
71CAMK10.72760201
72FGFR40.72173185
73CSNK1G20.72145138
74PASK0.71629088
75TESK10.70448390
76BRSK10.69081549
77MAP3K100.69015098
78ALK0.68842915
79STK110.68639959
80TNIK0.66009070
81SGK30.64597741
82DYRK1A0.63210259
83SGK4940.61104423
84SGK2230.61104423
85LRRK20.60778582
86TTN0.58897646
87DAPK30.58469436
88PRKCZ0.58121062
89PTK60.57549876
90HIPK20.57136426
91MAPKAPK30.57045376
92DMPK0.56795063
93RPS6KA20.56619567
94MAP2K10.56281695
95MAP3K10.54440716
96RIPK40.53089860
97WNK30.51495184
98CAMK2A0.51174049
99PRKCH0.51023239
100CAMK2G0.50433646
101MAP2K30.50154706
102MAP3K130.50026165
103AURKA0.49116103
104MAP3K110.48900444
105MOS0.48524057
106PAK40.48259541
107CSNK1G30.47178300
108MAP2K20.47064500
109AKT20.46774563
110PINK10.45486216
111MAPK110.43671869
112RPS6KL10.43539946
113RPS6KC10.43539946
114RIPK10.43448198
115PTK2B0.43344481
116MAPK100.42793661
117ROCK20.40965883
118PDGFRA0.40114196
119MAP3K80.39222773
120PDK10.39158733
121MAPKAPK50.38889557
122ILK0.38471306
123FYN0.37846869
124ABL20.37755648
125PAK20.37538427
126EPHB20.37419737
127CAMK2B0.36063967
128MAPK90.34994895
129RPS6KA30.31996391
130WNK40.31974321
131MAP3K70.31928753
132PDPK10.31926971
133PLK20.31730862
134MAPK120.31546801
135CCNB10.30779122
136CAMK40.30117166
137CAMK1G0.29817626
138PDK40.29375046
139PDK30.29375046

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.39795293
2Nicotine addiction_Homo sapiens_hsa050332.98743240
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.82951400
4GABAergic synapse_Homo sapiens_hsa047272.44629529
5Long-term potentiation_Homo sapiens_hsa047202.41557789
6Circadian entrainment_Homo sapiens_hsa047132.37861807
7Olfactory transduction_Homo sapiens_hsa047402.33422919
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23633261
9Dopaminergic synapse_Homo sapiens_hsa047282.21029585
10Vitamin B6 metabolism_Homo sapiens_hsa007502.20057472
11Glutamatergic synapse_Homo sapiens_hsa047242.19175742
12Amphetamine addiction_Homo sapiens_hsa050312.11669356
13Morphine addiction_Homo sapiens_hsa050322.06729615
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01232523
15Cholinergic synapse_Homo sapiens_hsa047251.87302383
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.85309786
17Insulin secretion_Homo sapiens_hsa049111.80768678
18Salivary secretion_Homo sapiens_hsa049701.79760912
19Gastric acid secretion_Homo sapiens_hsa049711.72299691
20Gap junction_Homo sapiens_hsa045401.70128838
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67146922
22Oxytocin signaling pathway_Homo sapiens_hsa049211.65374689
23Cocaine addiction_Homo sapiens_hsa050301.64269303
24Cardiac muscle contraction_Homo sapiens_hsa042601.55686256
25GnRH signaling pathway_Homo sapiens_hsa049121.54090167
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50763802
27Long-term depression_Homo sapiens_hsa047301.50272940
28Renin secretion_Homo sapiens_hsa049241.44504886
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.42775255
30Biosynthesis of amino acids_Homo sapiens_hsa012301.39888557
31Glioma_Homo sapiens_hsa052141.36202618
32Chronic myeloid leukemia_Homo sapiens_hsa052201.33143385
33Oocyte meiosis_Homo sapiens_hsa041141.32377484
34Serotonergic synapse_Homo sapiens_hsa047261.32088928
35Estrogen signaling pathway_Homo sapiens_hsa049151.30849078
36Sulfur relay system_Homo sapiens_hsa041221.28673395
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26536617
38Taste transduction_Homo sapiens_hsa047421.26454062
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26273037
40Axon guidance_Homo sapiens_hsa043601.25307745
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23370012
42Calcium signaling pathway_Homo sapiens_hsa040201.18334122
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16642021
44Notch signaling pathway_Homo sapiens_hsa043301.15785190
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15205364
46VEGF signaling pathway_Homo sapiens_hsa043701.14239067
47Alcoholism_Homo sapiens_hsa050341.14121814
48Pentose phosphate pathway_Homo sapiens_hsa000301.12505714
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11097140
50Fructose and mannose metabolism_Homo sapiens_hsa000511.10309497
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.06808565
52Parkinsons disease_Homo sapiens_hsa050121.05783828
53ErbB signaling pathway_Homo sapiens_hsa040121.04380395
54Melanogenesis_Homo sapiens_hsa049161.04349623
55cAMP signaling pathway_Homo sapiens_hsa040240.99083503
56Collecting duct acid secretion_Homo sapiens_hsa049660.96068154
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95047317
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94951963
59Type II diabetes mellitus_Homo sapiens_hsa049300.94714582
60Pancreatic cancer_Homo sapiens_hsa052120.92172821
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90393803
62Arginine and proline metabolism_Homo sapiens_hsa003300.90187640
63Vibrio cholerae infection_Homo sapiens_hsa051100.89887858
64Colorectal cancer_Homo sapiens_hsa052100.89684771
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.89059072
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88839539
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87278889
68Non-small cell lung cancer_Homo sapiens_hsa052230.85722382
69Acute myeloid leukemia_Homo sapiens_hsa052210.85432113
70Carbon metabolism_Homo sapiens_hsa012000.84970526
71Endometrial cancer_Homo sapiens_hsa052130.83602730
72Alzheimers disease_Homo sapiens_hsa050100.83251391
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82712300
74mTOR signaling pathway_Homo sapiens_hsa041500.82662547
75Arginine biosynthesis_Homo sapiens_hsa002200.79041639
76Pancreatic secretion_Homo sapiens_hsa049720.78349615
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77171643
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.75951083
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75549177
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.72975793
81Inositol phosphate metabolism_Homo sapiens_hsa005620.72718259
82Renal cell carcinoma_Homo sapiens_hsa052110.71475045
83Oxidative phosphorylation_Homo sapiens_hsa001900.71449112
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70869279
85Dorso-ventral axis formation_Homo sapiens_hsa043200.69967407
86Dilated cardiomyopathy_Homo sapiens_hsa054140.68669418
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68538782
88HIF-1 signaling pathway_Homo sapiens_hsa040660.67475856
89Insulin signaling pathway_Homo sapiens_hsa049100.67265987
90Choline metabolism in cancer_Homo sapiens_hsa052310.66651494
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66466765
92Endocytosis_Homo sapiens_hsa041440.66412027
93Thyroid hormone synthesis_Homo sapiens_hsa049180.65142919
94Glucagon signaling pathway_Homo sapiens_hsa049220.63829879
95Phenylalanine metabolism_Homo sapiens_hsa003600.62467215
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61839112
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61687510
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58792421
99MAPK signaling pathway_Homo sapiens_hsa040100.58360965
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.57287817
101Other glycan degradation_Homo sapiens_hsa005110.56543433
102Galactose metabolism_Homo sapiens_hsa000520.56206867
103Huntingtons disease_Homo sapiens_hsa050160.54605316
104Prolactin signaling pathway_Homo sapiens_hsa049170.53823663
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53316023
106Prion diseases_Homo sapiens_hsa050200.52389666
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51779785
108Melanoma_Homo sapiens_hsa052180.51356308
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50191755
110B cell receptor signaling pathway_Homo sapiens_hsa046620.49699882
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48040466
112Wnt signaling pathway_Homo sapiens_hsa043100.47447981
113Rap1 signaling pathway_Homo sapiens_hsa040150.46168483
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44278449
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44107762
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43544586
117N-Glycan biosynthesis_Homo sapiens_hsa005100.43115486
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39755034
119Nitrogen metabolism_Homo sapiens_hsa009100.39372759
120Bladder cancer_Homo sapiens_hsa052190.38259027
121Ras signaling pathway_Homo sapiens_hsa040140.37463231
122Bile secretion_Homo sapiens_hsa049760.37163130
123AMPK signaling pathway_Homo sapiens_hsa041520.36698771
124Thyroid cancer_Homo sapiens_hsa052160.34657437
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33449191

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