RNF185

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.68020571
2Golgi transport vesicle coating (GO:0048200)4.68020571
3protein localization to endosome (GO:0036010)4.42243909
4piRNA metabolic process (GO:0034587)4.33254241
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.15399351
6L-phenylalanine catabolic process (GO:0006559)4.15399351
7regulation of female gonad development (GO:2000194)4.07370194
8barbed-end actin filament capping (GO:0051016)4.04863949
9urea metabolic process (GO:0019627)3.95975765
10urea cycle (GO:0000050)3.95975765
11virion attachment to host cell (GO:0019062)3.95403645
12adhesion of symbiont to host cell (GO:0044650)3.95403645
13L-phenylalanine metabolic process (GO:0006558)3.93985683
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.93985683
15ER overload response (GO:0006983)3.90363989
16negative regulation of sodium ion transport (GO:0010766)3.68096791
17COPII vesicle coating (GO:0048208)3.58725972
18nitrogen cycle metabolic process (GO:0071941)3.56573118
19lysine catabolic process (GO:0006554)3.53487484
20lysine metabolic process (GO:0006553)3.53487484
21negative regulation of meiosis (GO:0045835)3.53303361
22aromatic amino acid family catabolic process (GO:0009074)3.51623184
23cysteine metabolic process (GO:0006534)3.51128102
24serine family amino acid catabolic process (GO:0009071)3.50200956
25regulation of hippo signaling (GO:0035330)3.49286338
26drug catabolic process (GO:0042737)3.45595926
27snRNA transcription (GO:0009301)3.45365984
28regulation of chromatin binding (GO:0035561)3.45237634
29negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.44056975
30negative regulation of fibrinolysis (GO:0051918)3.42916017
31glycosphingolipid catabolic process (GO:0046479)3.37704165
32adhesion of symbiont to host (GO:0044406)3.37496762
33protein K6-linked ubiquitination (GO:0085020)3.36559797
34homocysteine metabolic process (GO:0050667)3.30551593
35amino-acid betaine metabolic process (GO:0006577)3.29195846
36sulfur amino acid catabolic process (GO:0000098)3.27542887
37glyoxylate metabolic process (GO:0046487)3.24060914
38one-carbon metabolic process (GO:0006730)3.21197039
39skin morphogenesis (GO:0043589)3.15861251
40pattern specification involved in kidney development (GO:0061004)3.09812213
41stress fiber assembly (GO:0043149)3.08118503
42activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.07478860
43mitotic metaphase plate congression (GO:0007080)3.07164057
44glycolipid catabolic process (GO:0019377)3.06670669
45peptidyl-glutamic acid carboxylation (GO:0017187)3.05532744
46protein carboxylation (GO:0018214)3.05532744
47tryptophan metabolic process (GO:0006568)3.02592601
48folic acid-containing compound biosynthetic process (GO:0009396)2.99695227
49tryptophan catabolic process (GO:0006569)2.97470253
50indole-containing compound catabolic process (GO:0042436)2.97470253
51indolalkylamine catabolic process (GO:0046218)2.97470253
52regulation of spindle organization (GO:0090224)2.96910429
53citrulline biosynthetic process (GO:0019240)2.96309734
54regulation of acrosome reaction (GO:0060046)2.96083926
55kynurenine metabolic process (GO:0070189)2.94784077
56oocyte maturation (GO:0001556)2.93785620
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.93781631
58regulation of meiosis (GO:0040020)2.93221526
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92535979
60peroxisome fission (GO:0016559)2.92333063
61oligosaccharide catabolic process (GO:0009313)2.92264745
62intestinal cholesterol absorption (GO:0030299)2.91535405
63misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.91222162
64proline biosynthetic process (GO:0006561)2.91165639
65positive regulation of nuclease activity (GO:0032075)2.89920941
66amino sugar catabolic process (GO:0046348)2.86255237
67glycine metabolic process (GO:0006544)2.85378001
68negative regulation of fatty acid biosynthetic process (GO:0045717)2.85298617
69bile acid biosynthetic process (GO:0006699)2.83039654
70negative regulation of fatty acid transport (GO:2000192)2.82455508
71positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.82121531
72complement activation, alternative pathway (GO:0006957)2.81556880
73type B pancreatic cell development (GO:0003323)2.80919749
74ceramide catabolic process (GO:0046514)2.79258578
75regulation of glucokinase activity (GO:0033131)2.77730545
76regulation of hexokinase activity (GO:1903299)2.77730545
77regulation of tight junction assembly (GO:2000810)2.76970894
78alpha-linolenic acid metabolic process (GO:0036109)2.76867363
79base-excision repair, AP site formation (GO:0006285)2.76211946
80triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.75536155
81negative regulation of protein localization to plasma membrane (GO:1903077)2.75351865
82histone H2A monoubiquitination (GO:0035518)2.74568921
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.74174800
84sphingosine metabolic process (GO:0006670)2.74015249
85urate metabolic process (GO:0046415)2.72699834
86DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72223609
87regulation of fibrinolysis (GO:0051917)2.72050242
88amyloid precursor protein catabolic process (GO:0042987)2.71946244
89notochord development (GO:0030903)2.70514224
90rRNA methylation (GO:0031167)2.69389901
91regulation of protein activation cascade (GO:2000257)2.68818633
92protein retention in ER lumen (GO:0006621)2.68262420
93mitochondrial calcium ion transport (GO:0006851)2.67580933
94triglyceride homeostasis (GO:0070328)2.67487313
95acylglycerol homeostasis (GO:0055090)2.67487313
96regulation of membrane protein ectodomain proteolysis (GO:0051043)2.67075319
97response to laminar fluid shear stress (GO:0034616)2.66510799
98gene silencing by RNA (GO:0031047)2.65109218
99high-density lipoprotein particle remodeling (GO:0034375)2.65064938
100positive regulation by symbiont of host defense response (GO:0052509)2.64536451
101modulation by symbiont of host defense response (GO:0052031)2.64536451
102modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64536451
103modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64536451
104positive regulation by organism of defense response of other organism involved in symbiotic interact2.64536451
105modulation by symbiont of host immune response (GO:0052553)2.64536451
106cellular response to unfolded protein (GO:0034620)2.64284672
107aromatic amino acid family metabolic process (GO:0009072)2.63255495
108cellular response to topologically incorrect protein (GO:0035967)2.62911648
109regulation of nuclease activity (GO:0032069)2.62068001
110ER-nucleus signaling pathway (GO:0006984)2.61800579
111folic acid metabolic process (GO:0046655)2.61378815
112tyrosine metabolic process (GO:0006570)2.60736521
113monoubiquitinated protein deubiquitination (GO:0035520)2.59853439
114pyrimidine nucleobase catabolic process (GO:0006208)2.59735066
115serine transport (GO:0032329)2.59634955
116female gamete generation (GO:0007292)2.59107759
117UDP-N-acetylglucosamine metabolic process (GO:0006047)2.58008782
118endoplasmic reticulum unfolded protein response (GO:0030968)2.57853055
119citrulline metabolic process (GO:0000052)2.56748257
120peptidyl-proline hydroxylation (GO:0019511)2.55669102
121histone H2A ubiquitination (GO:0033522)2.54887158
122transcytosis (GO:0045056)2.54323539
123serine family amino acid metabolic process (GO:0009069)2.54087922
124alpha-amino acid catabolic process (GO:1901606)2.53877958
125arginine metabolic process (GO:0006525)2.53811623
126sphingolipid catabolic process (GO:0030149)2.52626512
127type B pancreatic cell proliferation (GO:0044342)2.51523288
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.51001559
129negative regulation of smooth muscle cell migration (GO:0014912)2.50878494
130regulation of early endosome to late endosome transport (GO:2000641)2.49719760
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.48861281
132axon extension involved in axon guidance (GO:0048846)2.48861281
133intestinal absorption (GO:0050892)2.48858924
134membrane lipid catabolic process (GO:0046466)2.48343706
135regulation of extracellular matrix disassembly (GO:0010715)2.48033892
136regulation of complement activation (GO:0030449)2.47468639
137cell adhesion mediated by integrin (GO:0033627)2.47452930
138carnitine metabolic process (GO:0009437)2.46629610
139positive regulation of triglyceride lipase activity (GO:0061365)2.42943351
140positive regulation of lipoprotein lipase activity (GO:0051006)2.42943351
141endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.42079869
142regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41235068
143keratan sulfate catabolic process (GO:0042340)2.40432782
144detection of molecule of bacterial origin (GO:0032490)2.39913532
145linoleic acid metabolic process (GO:0043651)2.37595512
146protein hydroxylation (GO:0018126)2.37573725
147positive regulation of extracellular matrix organization (GO:1903055)2.36841491
148regulation of mononuclear cell migration (GO:0071675)2.34010952
149pinocytosis (GO:0006907)2.32500121
150positive regulation of cellular amide metabolic process (GO:0034250)2.29320795
151negative regulation of interleukin-12 production (GO:0032695)2.29066437
152L-serine transport (GO:0015825)2.28684374
153fibrinolysis (GO:0042730)2.28374967
154response to peptidoglycan (GO:0032494)2.28013608
155membrane protein intracellular domain proteolysis (GO:0031293)2.27458599
156positive regulation of receptor recycling (GO:0001921)2.27363080
157macroautophagy (GO:0016236)2.26250995
158regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.25468983
159vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.23805733
160substrate-dependent cell migration (GO:0006929)2.23773502
161epoxygenase P450 pathway (GO:0019373)2.23744257
162response to arsenic-containing substance (GO:0046685)2.21336335
163vesicle coating (GO:0006901)2.19380562
164negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.19216923
165regulation of heterotypic cell-cell adhesion (GO:0034114)2.17756290
166macrophage activation involved in immune response (GO:0002281)2.17568276
167regulation of cytokine secretion involved in immune response (GO:0002739)2.17360155
168low-density lipoprotein particle clearance (GO:0034383)2.16456187
169chondroitin sulfate biosynthetic process (GO:0030206)2.16379633
170negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.15820577
171diol metabolic process (GO:0034311)2.15063160
172cellular copper ion homeostasis (GO:0006878)2.14984869
173basement membrane organization (GO:0071711)2.14905117
174positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.13715690
1754-hydroxyproline metabolic process (GO:0019471)2.12191229
176cellular response to thyroid hormone stimulus (GO:0097067)2.12108999
177negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.11525619
178N-acetylneuraminate metabolic process (GO:0006054)2.11416390
179negative regulation of protein activation cascade (GO:2000258)2.11009629
180virion assembly (GO:0019068)2.11001946
181glial cell migration (GO:0008347)2.10623108
182negative regulation of glucose import (GO:0046325)2.07301892
183phospholipid efflux (GO:0033700)2.07282125
184endocytic recycling (GO:0032456)2.07178098
185regulation of plasminogen activation (GO:0010755)2.06978848
186cellular response to type I interferon (GO:0071357)2.06450216
187type I interferon signaling pathway (GO:0060337)2.06450216
188fat-soluble vitamin biosynthetic process (GO:0042362)2.05667406
189epithelial cell differentiation involved in prostate gland development (GO:0060742)2.05493782
190negative regulation of complement activation (GO:0045916)2.05169632

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.89998481
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.53714513
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.36144509
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.82334083
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.57180170
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.53134185
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.87871002
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.84448267
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.73438648
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66024534
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.63531901
12CLOCK_20551151_ChIP-Seq_293T_Human2.56127128
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.52832233
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52026265
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44911938
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.36835297
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34174919
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.28704514
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.27986418
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.27114412
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22555514
22GATA1_22025678_ChIP-Seq_K562_Human2.16436871
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.16281749
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.14501861
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.12463519
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12288983
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.08934931
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00498790
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99006997
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96788036
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.96239410
32LXR_22292898_ChIP-Seq_THP-1_Human1.93363877
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84457937
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.84206689
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.82433022
36NANOG_21062744_ChIP-ChIP_HESCs_Human1.81721445
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76352720
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76053029
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75210442
40KAP1_22055183_ChIP-Seq_ESCs_Mouse1.74467170
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63730830
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63229012
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62940469
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.62521141
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59500924
46ATF3_27146783_Chip-Seq_COLON_Human1.58087948
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57520042
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.55197231
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.51880522
50RACK7_27058665_Chip-Seq_MCF-7_Human1.50294906
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50121056
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49715525
53CHD1_26751641_Chip-Seq_LNCaP_Human1.48807290
54* GABP_19822575_ChIP-Seq_HepG2_Human1.48262840
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46155835
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43898461
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43555382
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43115260
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42281016
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.41129608
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41115925
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37796783
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36234008
64KDM5A_27292631_Chip-Seq_BREAST_Human1.35765288
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33834563
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33625521
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31587159
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31172804
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.30586193
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30485614
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.29591456
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29431518
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28415064
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28303957
75RUNX1_26923725_Chip-Seq_HPCs_Mouse1.27828826
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27605163
77TP53_22127205_ChIP-Seq_IMR90_Human1.26598074
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25827012
79ZNF263_19887448_ChIP-Seq_K562_Human1.25333280
80AR_21909140_ChIP-Seq_LNCAP_Human1.25048092
81* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24544769
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.24180064
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23534129
84KDM2B_26808549_Chip-Seq_DND41_Human1.23328548
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.22772322
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22173178
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22143901
88FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.21648670
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18621412
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18568933
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18457737
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18392838
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18327795
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17624129
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16972744
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16297792
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15570413
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15439294
99CDX2_22108803_ChIP-Seq_LS180_Human1.15061858
100KDM2B_26808549_Chip-Seq_K562_Human1.14369310
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13982524
102* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13219591
103TBX20_22328084_ChIP-Seq_HEART_Mouse1.13169423
104TBX20_22080862_ChIP-Seq_HEART_Mouse1.13169423
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13068714
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12666108
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12649961
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12289282
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11870903
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11757902
111* HNF4A_19822575_ChIP-Seq_HepG2_Human1.11478250
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11395281
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10706423
114BP1_19119308_ChIP-ChIP_Hs578T_Human1.10559314
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10372958
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09851374
117VDR_21846776_ChIP-Seq_THP-1_Human1.08949996
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08052957
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07231350
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07207054
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07030385
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06983259
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06983259
124CIITA_25753668_ChIP-Seq_RAJI_Human1.05807631
125ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05613240
126NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05575366
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05259073
128* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05214368
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05071638
130SMAD_19615063_ChIP-ChIP_OVARY_Human1.04731588
131UBF1/2_26484160_Chip-Seq_HMECs_Human1.04708552
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03792740
133BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03727773
134SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03472503
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02553599
136STAT1_17558387_ChIP-Seq_HELA_Human0.99947240
137SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99597917
138EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98719085
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98684440
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97808430
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97676297
142GATA6_25053715_ChIP-Seq_YYC3_Human0.97184695
143* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96967844
144TCF7_22412390_ChIP-Seq_EML_Mouse0.96422322
145MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96062387
146CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94452819
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94410128
148* TFEB_21752829_ChIP-Seq_HELA_Human0.93437837
149RUNX1_22412390_ChIP-Seq_EML_Mouse0.92545779
150SA1_27219007_Chip-Seq_ERYTHROID_Human0.92346724
151DCP1A_22483619_ChIP-Seq_HELA_Human0.91914065
152* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91558098
153SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91437873
154RARA_24833708_ChIP-Seq_LIVER_Mouse0.90369701
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89693256
156E2F1_21310950_ChIP-Seq_MCF-7_Human0.89035240
157STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88954380
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88384481
159SOX2_20726797_ChIP-Seq_SW620_Human0.88184982
160GATA4_25053715_ChIP-Seq_YYC3_Human0.87696104
161NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87687316
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.87485013
163STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87416564
164* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86776931
165PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86518393
166KAP1_27257070_Chip-Seq_ESCs_Mouse0.86005370
167SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85154720
168SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85139882
169TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84338906
170TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83171266
171EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82082548
172FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80903317
173* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.78529501
174FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77296251

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.37772006
2MP0005365_abnormal_bile_salt4.36074994
3MP0005360_urolithiasis4.30497489
4MP0005085_abnormal_gallbladder_physiolo3.43894633
5MP0008438_abnormal_cutaneous_collagen3.05280515
6MP0003303_peritoneal_inflammation2.85911183
7MP0008875_abnormal_xenobiotic_pharmacok2.85340348
8MP0003718_maternal_effect2.78535356
9MP0003172_abnormal_lysosome_physiology2.56890599
10MP0003806_abnormal_nucleotide_metabolis2.39561266
11MP0009840_abnormal_foam_cell2.33603881
12MP0005408_hypopigmentation2.23952622
13MP0000604_amyloidosis2.20732587
14MP0000343_altered_response_to2.18002346
15MP0003705_abnormal_hypodermis_morpholog2.14791961
16MP0003252_abnormal_bile_duct2.14339323
17MP0001666_abnormal_nutrient_absorption2.09105043
18MP0003693_abnormal_embryo_hatching2.08602763
19MP0003300_gastrointestinal_ulcer2.06621068
20MP0001958_emphysema2.04735935
21MP0003329_amyloid_beta_deposits1.98539690
22MP0003724_increased_susceptibility_to1.96867265
23MP0005083_abnormal_biliary_tract1.96819942
24MP0003436_decreased_susceptibility_to1.88332909
25MP0003566_abnormal_cell_adhesion1.85044901
26MP0003453_abnormal_keratinocyte_physiol1.84386154
27MP0010329_abnormal_lipoprotein_level1.81810574
28MP0005451_abnormal_body_composition1.77342533
29MP0004233_abnormal_muscle_weight1.76342932
30MP0002877_abnormal_melanocyte_morpholog1.75734643
31MP0003279_aneurysm1.73965101
32MP0003646_muscle_fatigue1.73919376
33MP0003091_abnormal_cell_migration1.73436527
34MP0002653_abnormal_ependyma_morphology1.71939353
35MP0006082_CNS_inflammation1.71335444
36MP0005220_abnormal_exocrine_pancreas1.71172940
37MP0005275_abnormal_skin_tensile1.69760831
38MP0005395_other_phenotype1.66377580
39MP0003941_abnormal_skin_development1.64821102
40MP0004272_abnormal_basement_membrane1.63728661
41MP0004858_abnormal_nervous_system1.61266906
42MP0002837_dystrophic_cardiac_calcinosis1.59504510
43MP0002138_abnormal_hepatobiliary_system1.56119804
44MP0003890_abnormal_embryonic-extraembry1.50219195
45MP0003191_abnormal_cellular_cholesterol1.49536802
46MP0010386_abnormal_urinary_bladder1.47445549
47MP0005332_abnormal_amino_acid1.46663721
48MP0005670_abnormal_white_adipose1.45322623
49MP0004510_myositis1.44133000
50MP0003075_altered_response_to1.44028638
51MP0004264_abnormal_extraembryonic_tissu1.43599224
52MP0010368_abnormal_lymphatic_system1.43050433
53MP0001119_abnormal_female_reproductive1.41505756
54MP0001542_abnormal_bone_strength1.41365889
55MP0004947_skin_inflammation1.39418639
56MP0002419_abnormal_innate_immunity1.37650203
57MP0009785_altered_susceptibility_to1.37535123
58MP0000015_abnormal_ear_pigmentation1.35088099
59MP0002254_reproductive_system_inflammat1.32667252
60MP0003828_pulmonary_edema1.31811029
61MP0000609_abnormal_liver_physiology1.31040198
62MP0001533_abnormal_skeleton_physiology1.30525900
63MP0009764_decreased_sensitivity_to1.28868043
64MP0005248_abnormal_Harderian_gland1.23846338
65MP0005164_abnormal_response_to1.23834095
66MP0005058_abnormal_lysosome_morphology1.23372653
67MP0003077_abnormal_cell_cycle1.23268994
68MP0003699_abnormal_female_reproductive1.21219148
69MP0002998_abnormal_bone_remodeling1.20808952
70MP0001849_ear_inflammation1.20698253
71MP0005389_reproductive_system_phenotype1.20049067
72MP0001919_abnormal_reproductive_system1.18658808
73MP0002295_abnormal_pulmonary_circulatio1.18104271
74MP0002796_impaired_skin_barrier1.17394479
75MP0004782_abnormal_surfactant_physiolog1.16518626
76MP0000920_abnormal_myelination1.16458449
77MP0005319_abnormal_enzyme/_coenzyme1.15924405
78MP0005646_abnormal_pituitary_gland1.15078473
79MP0003123_paternal_imprinting1.13378644
80MP0005171_absent_coat_pigmentation1.10810038
81MP0010234_abnormal_vibrissa_follicle1.09817131
82MP0003943_abnormal_hepatobiliary_system1.09686980
83MP0002148_abnormal_hypersensitivity_rea1.08580340
84MP0009672_abnormal_birth_weight1.07321994
85MP0003942_abnormal_urinary_system1.06416964
86MP0009697_abnormal_copulation1.06335318
87MP0000371_diluted_coat_color1.05770079
88MP0005084_abnormal_gallbladder_morpholo1.04668062
89MP0006054_spinal_hemorrhage1.04498844
90MP0003868_abnormal_feces_composition1.04492911
91MP0005501_abnormal_skin_physiology1.04114644
92MP0010352_gastrointestinal_tract_polyps1.03877609
93MP0001730_embryonic_growth_arrest1.03129698
94MP0008007_abnormal_cellular_replicative1.03097616
95MP0005380_embryogenesis_phenotype1.02342682
96MP0001672_abnormal_embryogenesis/_devel1.02342682
97MP0005025_abnormal_response_to1.02036068
98MP0004019_abnormal_vitamin_homeostasis1.01675157
99MP0003656_abnormal_erythrocyte_physiolo1.01362103
100MP0000598_abnormal_liver_morphology1.01244031
101MP0004957_abnormal_blastocyst_morpholog1.01187401
102MP0000858_altered_metastatic_potential1.00281221
103MP0009384_cardiac_valve_regurgitation0.99449052
104MP0003111_abnormal_nucleus_morphology0.99001831
105MP0002118_abnormal_lipid_homeostasis0.98675062
106MP0001944_abnormal_pancreas_morphology0.98506477
107MP0000678_abnormal_parathyroid_gland0.98035285
108MP0003448_altered_tumor_morphology0.96371751
109MP0002896_abnormal_bone_mineralization0.96337919
110MP0005166_decreased_susceptibility_to0.95819771
111MP0008260_abnormal_autophagy0.94841358
112MP0002088_abnormal_embryonic_growth/wei0.94356532
113MP0000653_abnormal_sex_gland0.92953583
114MP0005409_darkened_coat_color0.92925384
115MP0009643_abnormal_urine_homeostasis0.92619059
116MP0003195_calcinosis0.92238882
117MP0008469_abnormal_protein_level0.91416906
118MP0003984_embryonic_growth_retardation0.90918247
119MP0001697_abnormal_embryo_size0.90762020
120MP0000685_abnormal_immune_system0.89929045
121MP0005584_abnormal_enzyme/coenzyme_acti0.89368665
122MP0001915_intracranial_hemorrhage0.87279913
123MP0009053_abnormal_anal_canal0.86642931
124MP0005257_abnormal_intraocular_pressure0.86625371
125MP0005187_abnormal_penis_morphology0.86471150
126MP0001756_abnormal_urination0.86286927
127MP0002332_abnormal_exercise_endurance0.85037853
128MP0003221_abnormal_cardiomyocyte_apopto0.84738924
129MP0008789_abnormal_olfactory_epithelium0.83768990
130MP0000350_abnormal_cell_proliferation0.82837282
131MP0008004_abnormal_stomach_pH0.82732856
132MP0003634_abnormal_glial_cell0.82416725
133MP0001929_abnormal_gametogenesis0.82178155
134MP0000538_abnormal_urinary_bladder0.82117719
135MP0000767_abnormal_smooth_muscle0.82055670
136MP0000003_abnormal_adipose_tissue0.81773922
137MP0006036_abnormal_mitochondrial_physio0.81498444
138MP0002160_abnormal_reproductive_system0.81426749
139MP0003937_abnormal_limbs/digits/tail_de0.79945350
140MP0002168_other_aberrant_phenotype0.79507072
141MP0003690_abnormal_glial_cell0.78848345
142MP0002085_abnormal_embryonic_tissue0.78808642
143MP0002127_abnormal_cardiovascular_syste0.78477140
144MP0001845_abnormal_inflammatory_respons0.78073725
145MP0003011_delayed_dark_adaptation0.77554797
146MP0002078_abnormal_glucose_homeostasis0.77203643
147MP0005000_abnormal_immune_tolerance0.76580899
148MP0001216_abnormal_epidermal_layer0.76020464
149MP0008877_abnormal_DNA_methylation0.76017003
150MP0005390_skeleton_phenotype0.74861811
151MP0009703_decreased_birth_body0.73702193
152MP0003879_abnormal_hair_cell0.73053171
153MP0005595_abnormal_vascular_smooth0.73037648
154MP0004883_abnormal_blood_vessel0.71379587
155MP0003119_abnormal_digestive_system0.70580922
156MP0005023_abnormal_wound_healing0.70002044
157MP0002210_abnormal_sex_determination0.69957848
158MP0008874_decreased_physiological_sensi0.69184483
159MP0000467_abnormal_esophagus_morphology0.69144903
160MP0005197_abnormal_uvea_morphology0.68915501
161MP0002084_abnormal_developmental_patter0.68776548
162MP0002693_abnormal_pancreas_physiology0.68220864
163MP0000751_myopathy0.67218614
164MP0005623_abnormal_meninges_morphology0.67176489
165MP0003950_abnormal_plasma_membrane0.66618156
166MP0002135_abnormal_kidney_morphology0.66226268
167MP0000759_abnormal_skeletal_muscle0.65848367
168MP0005266_abnormal_metabolism0.65584918
169MP0000750_abnormal_muscle_regeneration0.64888264
170MP0001243_abnormal_dermal_layer0.64724005
171MP0002060_abnormal_skin_morphology0.64396675
172MP0005165_increased_susceptibility_to0.64255741
173MP0005503_abnormal_tendon_morphology0.64055295
174MP0002971_abnormal_brown_adipose0.63154040
175MP0005464_abnormal_platelet_physiology0.61894702

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)5.15053350
2Deep venous thrombosis (HP:0002625)5.06342211
3Abnormality of glycolipid metabolism (HP:0010969)4.81415438
4Abnormality of liposaccharide metabolism (HP:0010968)4.81415438
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.81415438
6Gout (HP:0001997)4.32734157
7Systemic lupus erythematosus (HP:0002725)4.06195192
8Vacuolated lymphocytes (HP:0001922)3.83404281
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.83367343
10Intrahepatic cholestasis (HP:0001406)3.80116495
11Vertebral compression fractures (HP:0002953)3.70042750
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.59358600
13Protrusio acetabuli (HP:0003179)3.47469967
14Abnormality of the common coagulation pathway (HP:0010990)3.44919969
15Cervical subluxation (HP:0003308)3.41645956
16Conjugated hyperbilirubinemia (HP:0002908)3.41126163
17Cortical dysplasia (HP:0002539)3.38471209
18Hyperglycinemia (HP:0002154)3.33797969
19Mitral stenosis (HP:0001718)3.29783549
20Hypobetalipoproteinemia (HP:0003563)3.27593725
21Abnormality of the intrinsic pathway (HP:0010989)3.23098697
22Premature rupture of membranes (HP:0001788)3.22946199
23Hyperglycemia (HP:0003074)3.19606861
24Generalized aminoaciduria (HP:0002909)3.15644709
25Shawl scrotum (HP:0000049)3.13530302
26Hyperammonemia (HP:0001987)3.08051144
27Hyperglycinuria (HP:0003108)2.97779518
28Abnormality of sulfur amino acid metabolism (HP:0004339)2.94383993
29Dysostosis multiplex (HP:0000943)2.93200469
30Abnormality of polysaccharide metabolism (HP:0011012)2.92655040
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.92655040
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.92655040
33Loss of speech (HP:0002371)2.92203891
34Hypolipoproteinemia (HP:0010981)2.92008226
35Hypoalphalipoproteinemia (HP:0003233)2.90175332
36Abnormality of purine metabolism (HP:0004352)2.89890394
37Urinary glycosaminoglycan excretion (HP:0003541)2.84380263
38Mucopolysacchariduria (HP:0008155)2.84380263
39Insulin-resistant diabetes mellitus (HP:0000831)2.83408097
40Xanthomatosis (HP:0000991)2.81030016
41Complement deficiency (HP:0004431)2.78804624
42Flat capital femoral epiphysis (HP:0003370)2.78082670
43Hyperuricemia (HP:0002149)2.72633111
44Increased purine levels (HP:0004368)2.72633111
45Abnormality of macrophages (HP:0004311)2.72614335
46Ketosis (HP:0001946)2.70508166
47Failure to thrive in infancy (HP:0001531)2.69487109
48Neurofibrillary tangles (HP:0002185)2.67038643
49Palpitations (HP:0001962)2.66206628
50Nuclear cataract (HP:0100018)2.64035462
51Enlarged kidneys (HP:0000105)2.62426124
52Axonal loss (HP:0003447)2.62391158
53Hyperlipoproteinemia (HP:0010980)2.61427142
54Cholecystitis (HP:0001082)2.53861593
55Abnormal gallbladder physiology (HP:0012438)2.53861593
56Abnormality of glycine metabolism (HP:0010895)2.50931110
57Abnormality of serine family amino acid metabolism (HP:0010894)2.50931110
58Complete atrioventricular canal defect (HP:0001674)2.50875669
59Prolonged partial thromboplastin time (HP:0003645)2.50496490
60Papillary thyroid carcinoma (HP:0002895)2.50019801
61Ketoacidosis (HP:0001993)2.49423934
62Fat malabsorption (HP:0002630)2.49038720
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.48319870
64Abnormality of nucleobase metabolism (HP:0010932)2.43804981
65Abnormality of fatty-acid metabolism (HP:0004359)2.43572995
66Abnormality of the labia minora (HP:0012880)2.42092040
67Insulin resistance (HP:0000855)2.40662484
68Spinal rigidity (HP:0003306)2.37632814
69Ankle contracture (HP:0006466)2.35774398
70Malnutrition (HP:0004395)2.33780067
71Asymmetric septal hypertrophy (HP:0001670)2.33306400
72Poor coordination (HP:0002370)2.28043135
73Abnormality of lateral ventricle (HP:0030047)2.27217515
74Prolonged neonatal jaundice (HP:0006579)2.22447334
75Eczematoid dermatitis (HP:0000976)2.20447780
76Increased variability in muscle fiber diameter (HP:0003557)2.20409751
77Cerebral inclusion bodies (HP:0100314)2.18708670
78Chorioretinal atrophy (HP:0000533)2.17643507
79Ovoid vertebral bodies (HP:0003300)2.16765810
80Abnormality of serum amino acid levels (HP:0003112)2.15042197
81Joint hemorrhage (HP:0005261)2.14767005
82Vascular tortuosity (HP:0004948)2.13952289
83Purpura (HP:0000979)2.13692060
84Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11049789
85Premature ovarian failure (HP:0008209)2.09069170
86Abnormal pancreas size (HP:0012094)2.07904124
87Hypothermia (HP:0002045)2.07891683
88Hand muscle atrophy (HP:0009130)2.05059024
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03540053
90Lymphangioma (HP:0100764)2.03230572
91Wrist flexion contracture (HP:0001239)2.02558431
92Glomerulonephritis (HP:0000099)2.01580570
93Upper limb amyotrophy (HP:0009129)2.01014369
94Distal upper limb amyotrophy (HP:0007149)2.01014369
95Delayed puberty (HP:0000823)2.00270873
96Right ventricular cardiomyopathy (HP:0011663)2.00126918
97Progressive neurologic deterioration (HP:0002344)1.99517388
98Late onset (HP:0003584)1.98945869
99Secondary amenorrhea (HP:0000869)1.98644181
100Increased cerebral lipofuscin (HP:0011813)1.97582059
101Segmental peripheral demyelination/remyelination (HP:0003481)1.95863569
102Cystic hygroma (HP:0000476)1.94947066
103Aplasia/Hypoplasia of the patella (HP:0006498)1.94886287
104Hypoglycemic coma (HP:0001325)1.93574597
105Interstitial pulmonary disease (HP:0006530)1.91499102
106Abnormality of the proximal phalanges of the hand (HP:0009834)1.91151997
107Patellar aplasia (HP:0006443)1.90760859
108Arterial tortuosity (HP:0005116)1.90434467
109Genu recurvatum (HP:0002816)1.90386610
110Aortic aneurysm (HP:0004942)1.88763240
111Amyloidosis (HP:0011034)1.88019888
112Hepatocellular carcinoma (HP:0001402)1.87885925
113Exocrine pancreatic insufficiency (HP:0001738)1.87508052
114Infertility (HP:0000789)1.87371080
115Abnormality of skeletal muscle fiber size (HP:0012084)1.87199025
116Myocardial infarction (HP:0001658)1.87128302
117Abnormality of complement system (HP:0005339)1.86680235
118Nephrogenic diabetes insipidus (HP:0009806)1.86115664
119Diminished motivation (HP:0000745)1.85846225
120Supranuclear gaze palsy (HP:0000605)1.85642056
121Multiple lipomas (HP:0001012)1.84165934
122Apathy (HP:0000741)1.83545922
123Peripheral hypomyelination (HP:0007182)1.82406901
124Aortic dissection (HP:0002647)1.81063877
125Albinism (HP:0001022)1.80758308
126Peritonitis (HP:0002586)1.80551658
127Abnormality of the lower motor neuron (HP:0002366)1.80292943
128Orchitis (HP:0100796)1.80149525
129Steatorrhea (HP:0002570)1.78681830
130Birth length less than 3rd percentile (HP:0003561)1.78217869
131Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78034130
132Hyperextensible skin (HP:0000974)1.76852153
133Joint stiffness (HP:0001387)1.76499044
134Neoplasm of the adrenal gland (HP:0100631)1.76445055
135Long toe (HP:0010511)1.76139790
136Neonatal onset (HP:0003623)1.75964194
137Hypoplasia of the iris (HP:0007676)1.75293434
138Peripheral demyelination (HP:0011096)1.75111067
139Blue sclerae (HP:0000592)1.74678657
140Atrophic scars (HP:0001075)1.73426004
141Wormian bones (HP:0002645)1.72435926
142Abnormal cartilage morphology (HP:0002763)1.71521100
143Hypochromic microcytic anemia (HP:0004840)1.70957972
144Slender build (HP:0001533)1.70934662
145Hepatoblastoma (HP:0002884)1.70424795
146Cardiovascular calcification (HP:0011915)1.69859714
147Hypoplasia of the fovea (HP:0007750)1.69478514
148Aplasia/Hypoplasia of the fovea (HP:0008060)1.69478514
149Capillary hemangiomas (HP:0005306)1.68579722
150Bony spicule pigmentary retinopathy (HP:0007737)1.68221929
151Muscle fibrillation (HP:0010546)1.68201135
152Aortic valve stenosis (HP:0001650)1.68090031
153Upper motor neuron abnormality (HP:0002127)1.67195714
154Thin bony cortex (HP:0002753)1.67044412
155Tongue fasciculations (HP:0001308)1.66487933
156Chronic hepatic failure (HP:0100626)1.66469734
157Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.66351033
158Adrenal hypoplasia (HP:0000835)1.65853924
159Hyperparathyroidism (HP:0000843)1.65589325
160Increased IgE level (HP:0003212)1.65389702
161Elevated alkaline phosphatase (HP:0003155)1.65386944
162Thickened nuchal skin fold (HP:0000474)1.65142322
163Skin nodule (HP:0200036)1.64964378
164Metabolic acidosis (HP:0001942)1.64143986
165Proximal tubulopathy (HP:0000114)1.64063893
166Mitral regurgitation (HP:0001653)1.63879031
167Atrioventricular canal defect (HP:0006695)1.63668384
168Neonatal hypoglycemia (HP:0001998)1.63546592
169Neoplasm of the tracheobronchial system (HP:0100552)1.63473629
170Abnormality of carpal bone ossification (HP:0006257)1.63427118
171Dilatation of the ascending aorta (HP:0005111)1.62279288
172Myositis (HP:0100614)1.61940248
173Bladder diverticulum (HP:0000015)1.61748605
174Hammertoe (HP:0001765)1.61451576
175Aneurysm (HP:0002617)1.61369430
176Increased connective tissue (HP:0009025)1.61343660
177Follicular hyperkeratosis (HP:0007502)1.60652066
178Centrally nucleated skeletal muscle fibers (HP:0003687)1.59962544
179Cardiomegaly (HP:0001640)1.59929738
180Neoplasm of the adrenal cortex (HP:0100641)1.59799094
181Bone pain (HP:0002653)1.58855336
182Emphysema (HP:0002097)1.57222363
183Aortic regurgitation (HP:0001659)1.56202506
184Sensorimotor neuropathy (HP:0007141)1.55697303
185Cerebral aneurysm (HP:0004944)1.55507818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.46173087
2STK38L3.78401808
3MAP3K63.38309115
4LATS23.12085734
5ERN13.08359409
6PIM22.83361238
7AKT32.82962416
8BRAF2.61839475
9RIPK12.61049499
10EPHB12.55278914
11IRAK32.47768969
12DDR22.40538866
13ERBB42.38704735
14BRD42.37080197
15TRIB32.28983765
16NEK92.24272810
17TAOK32.14475682
18SGK22.10185058
19MAPKAPK32.08054428
20PLK42.02951544
21DYRK1B1.88490365
22TTK1.87974533
23ARAF1.87107832
24PDK21.82105315
25SGK31.80195815
26TBK11.76145830
27BCKDK1.74653977
28FRK1.67072364
29EEF2K1.65598338
30TESK11.64887515
31KSR21.58934426
32CDK81.55966061
33FGFR41.48793416
34PRKD21.42948842
35MAP3K41.41285110
36MOS1.40059144
37EPHA31.39042356
38SGK2231.35641878
39SGK4941.35641878
40PAK41.31762846
41PDGFRA1.29531389
42TIE11.27892241
43EPHB21.27172621
44BMPR21.23827977
45MYLK1.21509463
46STK31.18107544
47MELK1.15975211
48ICK1.14085660
49SIK11.12517760
50CDC42BPA1.10809085
51FGR1.08669976
52MAP3K11.08469295
53DAPK21.08116979
54MAP3K111.07859725
55DYRK21.06937829
56CCNB11.02769794
57BLK1.01994105
58TGFBR10.99194381
59MAP3K140.97960683
60DAPK30.97580837
61TYRO30.95810742
62CDK90.95635206
63MAP2K40.95219407
64PDK40.94865708
65PDK30.94865708
66PRKD30.94736461
67EPHA20.94402295
68SMG10.93261586
69TAOK10.92561413
70JAK10.91567511
71IRAK40.90624243
72TESK20.89536908
73PLK10.88866696
74FGFR20.88330637
75PAK60.86392452
76TGFBR20.84678247
77MAP3K50.83678543
78KSR10.83568054
79NME20.80624532
80MAPK130.79023647
81CSK0.78786134
82TRIM280.77765670
83MAP3K30.76989853
84PTK20.76566311
85MAP2K10.74636794
86SCYL20.74094310
87MARK20.73932479
88MAP3K90.73054718
89NEK10.72799622
90CHEK20.72351694
91ZAP700.72113769
92INSRR0.69142211
93MAP3K130.68983987
94KDR0.68525444
95TRPM70.66719423
96MATK0.66408411
97MAP2K70.66346701
98PINK10.64599794
99MTOR0.64360127
100PKN20.63849594
101GRK70.63517817
102LIMK10.63337640
103AURKA0.62655564
104CDK120.61294903
105MARK10.60680268
106STK380.60561916
107TTN0.60202666
108BCR0.58395919
109ROCK20.57234699
110RET0.57074482
111RAF10.56451314
112MET0.55567236
113PRKAA10.54647602
114CDK60.54290373
115PLK30.54205868
116NTRK20.53614981
117RPS6KA20.53044858
118STK240.52275299
119RPS6KA40.52265203
120NUAK10.51938207
121SRPK10.51936890
122CSNK1A1L0.51713853
123LRRK20.51696754
124JAK30.51692967
125STK100.51431160
126IKBKE0.50887951
127MAPKAPK20.49985169
128FGFR30.49088716
129PRKG20.48878947
130RPS6KL10.48301688
131RPS6KC10.48301688
132ABL20.47570415
133PAK20.46937890
134PRKAA20.46140859
135NEK20.45766886
136SIK30.43011863
137TYK20.42285714
138JAK20.41622129
139YES10.40451925
140NEK60.40132298
141LMTK20.39577032
142GSK3A0.38526287
143PDGFRB0.38219658
144MAPK70.37564940
145PTK60.36279928
146CSNK1G30.36020298
147MAP3K80.35749267
148TAOK20.35447988
149PDK10.35370474
150MAPKAPK50.35312263
151MAP2K30.33601306
152BUB10.33038366
153PRPF4B0.32380849
154MAPK110.29270528
155BMPR1B0.26315055
156FER0.25216176
157PDPK10.23868903
158EIF2AK10.22277183
159DAPK10.21325876
160RPS6KB10.21110763
161MUSK0.20897895

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41830456
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.12378287
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.63802940
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40577176
5Arginine biosynthesis_Homo sapiens_hsa002202.39652198
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32949893
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.28672063
8Caffeine metabolism_Homo sapiens_hsa002322.18692955
9Drug metabolism - other enzymes_Homo sapiens_hsa009832.17498024
10Fatty acid degradation_Homo sapiens_hsa000712.16055051
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.05940859
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03214943
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02192443
14Vitamin B6 metabolism_Homo sapiens_hsa007501.99351361
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90559813
16Tryptophan metabolism_Homo sapiens_hsa003801.88827193
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.87445099
18Propanoate metabolism_Homo sapiens_hsa006401.81992889
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77248032
20Selenocompound metabolism_Homo sapiens_hsa004501.76091746
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75490284
22Complement and coagulation cascades_Homo sapiens_hsa046101.71432821
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65598008
24Nitrogen metabolism_Homo sapiens_hsa009101.65516077
25Fatty acid metabolism_Homo sapiens_hsa012121.62446653
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56990799
27* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54662755
28Sphingolipid metabolism_Homo sapiens_hsa006001.53868415
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.53825870
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.50261553
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49700708
32beta-Alanine metabolism_Homo sapiens_hsa004101.49537470
33Peroxisome_Homo sapiens_hsa041461.47738207
34Vibrio cholerae infection_Homo sapiens_hsa051101.46384182
35PPAR signaling pathway_Homo sapiens_hsa033201.45770048
36Folate biosynthesis_Homo sapiens_hsa007901.42371703
37Biosynthesis of amino acids_Homo sapiens_hsa012301.37319180
38Pyruvate metabolism_Homo sapiens_hsa006201.37266299
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35747609
40Osteoclast differentiation_Homo sapiens_hsa043801.35220493
41Phagosome_Homo sapiens_hsa041451.34161476
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33239641
43Malaria_Homo sapiens_hsa051441.25527634
44Pertussis_Homo sapiens_hsa051331.24739679
45Butanoate metabolism_Homo sapiens_hsa006501.23775879
46Chemical carcinogenesis_Homo sapiens_hsa052041.23578889
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20576766
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.19949846
49Starch and sucrose metabolism_Homo sapiens_hsa005001.14883385
50Fructose and mannose metabolism_Homo sapiens_hsa000511.11751153
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11671568
52Circadian rhythm_Homo sapiens_hsa047101.10922537
53Salmonella infection_Homo sapiens_hsa051321.08771767
54Hepatitis C_Homo sapiens_hsa051601.07262306
55Tuberculosis_Homo sapiens_hsa051521.05874346
56Galactose metabolism_Homo sapiens_hsa000521.04920262
57TNF signaling pathway_Homo sapiens_hsa046681.04888129
58Fatty acid elongation_Homo sapiens_hsa000621.04429425
59Retinol metabolism_Homo sapiens_hsa008301.01231708
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00562105
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00126247
62Histidine metabolism_Homo sapiens_hsa003400.99756488
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99281118
64Regulation of autophagy_Homo sapiens_hsa041400.99011433
65Insulin resistance_Homo sapiens_hsa049310.98353146
66One carbon pool by folate_Homo sapiens_hsa006700.97933803
67Arginine and proline metabolism_Homo sapiens_hsa003300.96983141
68Sulfur metabolism_Homo sapiens_hsa009200.95965634
69Pancreatic cancer_Homo sapiens_hsa052120.93961062
70Carbon metabolism_Homo sapiens_hsa012000.93433819
71Notch signaling pathway_Homo sapiens_hsa043300.91006825
72mTOR signaling pathway_Homo sapiens_hsa041500.90048653
73Steroid biosynthesis_Homo sapiens_hsa001000.88825177
74Legionellosis_Homo sapiens_hsa051340.88762910
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88746962
76Endocytosis_Homo sapiens_hsa041440.88739658
77RNA degradation_Homo sapiens_hsa030180.88304768
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87934670
79Cell cycle_Homo sapiens_hsa041100.87067598
80Influenza A_Homo sapiens_hsa051640.86327908
81Protein export_Homo sapiens_hsa030600.86182981
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85266130
83Fat digestion and absorption_Homo sapiens_hsa049750.85084492
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84725494
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82263336
86Vitamin digestion and absorption_Homo sapiens_hsa049770.81909227
87Acute myeloid leukemia_Homo sapiens_hsa052210.81813001
88Glycerolipid metabolism_Homo sapiens_hsa005610.78584879
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78576972
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77731354
91Lysine degradation_Homo sapiens_hsa003100.76462014
92Shigellosis_Homo sapiens_hsa051310.76421763
93Endometrial cancer_Homo sapiens_hsa052130.76368891
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.76088495
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.74841746
96Amoebiasis_Homo sapiens_hsa051460.74794439
97Measles_Homo sapiens_hsa051620.74411919
98Apoptosis_Homo sapiens_hsa042100.73996783
99Hepatitis B_Homo sapiens_hsa051610.73533222
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72774661
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72416003
102Leishmaniasis_Homo sapiens_hsa051400.71565900
103Toxoplasmosis_Homo sapiens_hsa051450.71223290
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70833596
105RNA transport_Homo sapiens_hsa030130.70137434
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67876721
107Prolactin signaling pathway_Homo sapiens_hsa049170.67453348
108AMPK signaling pathway_Homo sapiens_hsa041520.66988184
109Rheumatoid arthritis_Homo sapiens_hsa053230.66236082
110FoxO signaling pathway_Homo sapiens_hsa040680.66059999
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.65712117
112VEGF signaling pathway_Homo sapiens_hsa043700.63172765
113Proteoglycans in cancer_Homo sapiens_hsa052050.63118644
114Ovarian steroidogenesis_Homo sapiens_hsa049130.63055564
115Phenylalanine metabolism_Homo sapiens_hsa003600.62932144
116Focal adhesion_Homo sapiens_hsa045100.62656488
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62396193
118Staphylococcus aureus infection_Homo sapiens_hsa051500.62218546
119Prion diseases_Homo sapiens_hsa050200.58768398
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58557380
121TGF-beta signaling pathway_Homo sapiens_hsa043500.57862505
122Collecting duct acid secretion_Homo sapiens_hsa049660.57511591
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.55474429
124Colorectal cancer_Homo sapiens_hsa052100.53492372
125Glucagon signaling pathway_Homo sapiens_hsa049220.53205245
126Viral myocarditis_Homo sapiens_hsa054160.53071363
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52066139
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.51943576
129Insulin signaling pathway_Homo sapiens_hsa049100.51372313
130Tyrosine metabolism_Homo sapiens_hsa003500.51346571
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.49183090
132N-Glycan biosynthesis_Homo sapiens_hsa005100.47595595
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47138489
134Thyroid cancer_Homo sapiens_hsa052160.47046259
135Bile secretion_Homo sapiens_hsa049760.46953746
136Basal transcription factors_Homo sapiens_hsa030220.46252121
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45021217
138Other glycan degradation_Homo sapiens_hsa005110.44999557
139Non-small cell lung cancer_Homo sapiens_hsa052230.44785971
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44420778
141Chemokine signaling pathway_Homo sapiens_hsa040620.44271445
142Oocyte meiosis_Homo sapiens_hsa041140.43533108
143p53 signaling pathway_Homo sapiens_hsa041150.42710775
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.42490221
145B cell receptor signaling pathway_Homo sapiens_hsa046620.42140510
146Glioma_Homo sapiens_hsa052140.42046126
147Hippo signaling pathway_Homo sapiens_hsa043900.41939051
148Adherens junction_Homo sapiens_hsa045200.40170486
149Bladder cancer_Homo sapiens_hsa052190.38947469
150Lysosome_Homo sapiens_hsa041420.38601239
151Prostate cancer_Homo sapiens_hsa052150.38559753
152Renal cell carcinoma_Homo sapiens_hsa052110.37863964
153Glutathione metabolism_Homo sapiens_hsa004800.35110222
154Sulfur relay system_Homo sapiens_hsa041220.34444997
155Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32738137
156Pentose phosphate pathway_Homo sapiens_hsa000300.32606114
157Chronic myeloid leukemia_Homo sapiens_hsa052200.31835750

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