RNF170

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.57105347
2neurotransmitter-gated ion channel clustering (GO:0072578)4.51256121
3epithelial cilium movement (GO:0003351)3.92117186
4regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75044693
5axoneme assembly (GO:0035082)3.71522605
6pyrimidine nucleobase catabolic process (GO:0006208)3.65150288
7nonmotile primary cilium assembly (GO:0035058)3.64581046
8presynaptic membrane assembly (GO:0097105)3.62626639
9platelet dense granule organization (GO:0060155)3.52418417
10L-fucose metabolic process (GO:0042354)3.51590819
11L-fucose catabolic process (GO:0042355)3.51590819
12fucose catabolic process (GO:0019317)3.51590819
13cellular glucuronidation (GO:0052695)3.44668665
14response to pheromone (GO:0019236)3.43910695
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43035321
16nucleobase catabolic process (GO:0046113)3.42313317
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41430205
18intraciliary transport (GO:0042073)3.40126510
19neuron cell-cell adhesion (GO:0007158)3.33460325
20negative regulation of dendrite morphogenesis (GO:0050774)3.27275817
21vocalization behavior (GO:0071625)3.25886100
22cilium morphogenesis (GO:0060271)3.23697103
23uronic acid metabolic process (GO:0006063)3.23359197
24glucuronate metabolic process (GO:0019585)3.23359197
25water-soluble vitamin biosynthetic process (GO:0042364)3.22188193
26high-density lipoprotein particle remodeling (GO:0034375)3.19536810
27protein polyglutamylation (GO:0018095)3.17805236
28cilium movement (GO:0003341)3.15410835
29L-phenylalanine catabolic process (GO:0006559)3.15202584
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.15202584
31aromatic amino acid family catabolic process (GO:0009074)3.07711391
32regulation of cilium movement (GO:0003352)3.06479583
33glutamate receptor signaling pathway (GO:0007215)3.04561556
34negative regulation of lipase activity (GO:0060192)3.03088230
35regulation of glutamate receptor signaling pathway (GO:1900449)3.02422349
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01404894
37protein localization to synapse (GO:0035418)3.01318752
38neuronal action potential propagation (GO:0019227)3.00270286
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99845955
40photoreceptor cell maintenance (GO:0045494)2.97629595
41neuron-neuron synaptic transmission (GO:0007270)2.97243448
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.96882400
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.96561869
44bile acid biosynthetic process (GO:0006699)2.96393777
45synaptic transmission, glutamatergic (GO:0035249)2.96128584
46gamma-aminobutyric acid transport (GO:0015812)2.94236326
47synaptic vesicle exocytosis (GO:0016079)2.93389064
48respiratory chain complex IV assembly (GO:0008535)2.91921142
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.91599514
50cilium organization (GO:0044782)2.89924191
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88750834
52low-density lipoprotein particle remodeling (GO:0034374)2.87315681
53ionotropic glutamate receptor signaling pathway (GO:0035235)2.87046242
54reverse cholesterol transport (GO:0043691)2.86684217
55negative regulation of dendrite development (GO:2000171)2.86369362
56synaptic vesicle docking involved in exocytosis (GO:0016081)2.84923958
57phospholipid efflux (GO:0033700)2.84917824
58cilium assembly (GO:0042384)2.83686808
59protein complex biogenesis (GO:0070271)2.82799866
60detection of calcium ion (GO:0005513)2.81832663
61presynaptic membrane organization (GO:0097090)2.80771857
62tryptophan catabolic process (GO:0006569)2.80519057
63indole-containing compound catabolic process (GO:0042436)2.80519057
64indolalkylamine catabolic process (GO:0046218)2.80519057
65regulation of glucokinase activity (GO:0033131)2.79468013
66regulation of hexokinase activity (GO:1903299)2.79468013
67gamma-aminobutyric acid signaling pathway (GO:0007214)2.79206001
68protein-lipid complex remodeling (GO:0034368)2.79188458
69macromolecular complex remodeling (GO:0034367)2.79188458
70plasma lipoprotein particle remodeling (GO:0034369)2.79188458
71prostate gland growth (GO:0060736)2.77684537
72regulation of action potential (GO:0098900)2.77493877
73proline transport (GO:0015824)2.75445431
74behavioral response to cocaine (GO:0048148)2.74773404
75neurotransmitter secretion (GO:0007269)2.74735334
76behavioral response to ethanol (GO:0048149)2.74651868
77negative regulation of heart rate (GO:0010459)2.72683080
78cellular ketone body metabolic process (GO:0046950)2.72297643
79retinal cone cell development (GO:0046549)2.72004073
80cytochrome complex assembly (GO:0017004)2.70386703
81urea metabolic process (GO:0019627)2.69919599
82urea cycle (GO:0000050)2.69919599
83tryptophan metabolic process (GO:0006568)2.69313712
84inositol phosphate catabolic process (GO:0071545)2.69112905
85righting reflex (GO:0060013)2.68151800
86regulation of cholesterol esterification (GO:0010872)2.68146835
87glycerophospholipid catabolic process (GO:0046475)2.67887598
88L-phenylalanine metabolic process (GO:0006558)2.67784932
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.67784932
90startle response (GO:0001964)2.67762680
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67035498
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66758785
93dendritic spine morphogenesis (GO:0060997)2.65689664
94female mating behavior (GO:0060180)2.65125287
95detection of light stimulus involved in visual perception (GO:0050908)2.63765245
96detection of light stimulus involved in sensory perception (GO:0050962)2.63765245
97neural tube formation (GO:0001841)2.62651788
98protein localization to cilium (GO:0061512)2.60492071
99mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60090276
100cholesterol efflux (GO:0033344)2.59164560
101C4-dicarboxylate transport (GO:0015740)2.58163057
102magnesium ion transport (GO:0015693)2.58129182
103glutamate secretion (GO:0014047)2.58108061
104regulation of female receptivity (GO:0045924)2.57950850
105protein neddylation (GO:0045116)2.57281271
106adenosine metabolic process (GO:0046085)2.56900695
107ER overload response (GO:0006983)2.56695527
108protein-cofactor linkage (GO:0018065)2.56653913
109regulation of synaptic vesicle transport (GO:1902803)2.55074196
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54439346
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.54439346
112NADH dehydrogenase complex assembly (GO:0010257)2.54439346
113base-excision repair, AP site formation (GO:0006285)2.54383772
114brain morphogenesis (GO:0048854)2.52142331
115bile acid metabolic process (GO:0008206)2.51982137
116piRNA metabolic process (GO:0034587)2.51374243
117calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51221212
118photoreceptor cell development (GO:0042461)2.49670052
119DNA deamination (GO:0045006)2.49478616
120nephron tubule morphogenesis (GO:0072078)2.48771432
121nephron epithelium morphogenesis (GO:0072088)2.48771432
122short-chain fatty acid metabolic process (GO:0046459)2.48585740
123negative regulation of protein activation cascade (GO:2000258)2.47954005
124regulation of microtubule-based movement (GO:0060632)2.47067968
125tyrosine metabolic process (GO:0006570)2.46436892
126positive regulation of cardiac muscle hypertrophy (GO:0010613)2.45430613
127positive regulation of muscle hypertrophy (GO:0014742)2.45430613
128mitochondrial respiratory chain complex assembly (GO:0033108)2.45002066
129regulation of glycogen (starch) synthase activity (GO:2000465)2.44504600
130drug catabolic process (GO:0042737)2.43959305
131synaptic transmission, cholinergic (GO:0007271)2.43362443
132long-term synaptic potentiation (GO:0060291)2.43081944
133coenzyme catabolic process (GO:0009109)2.42692738
134positive regulation of meiosis (GO:0045836)2.42575457
135regulation of synaptic vesicle exocytosis (GO:2000300)2.42527258
136indolalkylamine metabolic process (GO:0006586)2.42483329
137regulation of clathrin-mediated endocytosis (GO:2000369)2.42416766
138behavioral response to nicotine (GO:0035095)2.42225472
139kidney morphogenesis (GO:0060993)2.42185179
140sulfation (GO:0051923)2.41584310
141synapse assembly (GO:0007416)2.41038238
142postsynaptic membrane organization (GO:0001941)2.40999798
143peptidyl-glutamic acid carboxylation (GO:0017187)2.40977390
144protein carboxylation (GO:0018214)2.40977390
145tachykinin receptor signaling pathway (GO:0007217)2.40006515
146negative regulation of response to food (GO:0032096)2.39376225
147negative regulation of appetite (GO:0032099)2.39376225
148serotonin receptor signaling pathway (GO:0007210)2.39319257
149vesicle docking involved in exocytosis (GO:0006904)2.38676760
150estrogen biosynthetic process (GO:0006703)2.37073593
151positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.37022320
152mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.37022320
153parturition (GO:0007567)2.36910308
154retinal ganglion cell axon guidance (GO:0031290)2.36809745
155mannosylation (GO:0097502)2.36678896
156positive regulation of meiotic cell cycle (GO:0051446)2.36625018
157anterograde synaptic vesicle transport (GO:0048490)2.36142945
158neurotransmitter transport (GO:0006836)2.35904143
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.35660939
160innervation (GO:0060384)2.35438785
161lysine metabolic process (GO:0006553)2.34216357
162lysine catabolic process (GO:0006554)2.34216357
163negative regulation of complement activation (GO:0045916)2.33852565
164protein prenylation (GO:0018342)2.33664760
165prenylation (GO:0097354)2.33664760
166synaptic vesicle endocytosis (GO:0048488)2.33612437
167neuronal action potential (GO:0019228)2.33163203
168substrate-independent telencephalic tangential migration (GO:0021826)2.32321452
169substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.32321452
170ketone body metabolic process (GO:1902224)2.32308371
171kynurenine metabolic process (GO:0070189)2.32295356
172regulation of neuronal synaptic plasticity (GO:0048168)2.31079209
173nitrogen cycle metabolic process (GO:0071941)2.31060389
174regulation of meiosis I (GO:0060631)2.30598447
175transmission of nerve impulse (GO:0019226)2.30310475
176phosphorylated carbohydrate dephosphorylation (GO:0046838)2.30025620
177inositol phosphate dephosphorylation (GO:0046855)2.30025620
178nitric oxide mediated signal transduction (GO:0007263)2.29864178
179preassembly of GPI anchor in ER membrane (GO:0016254)2.29489018
180cellular component assembly involved in morphogenesis (GO:0010927)2.28938152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.01292137
2ZNF274_21170338_ChIP-Seq_K562_Hela3.00329491
3EZH2_22144423_ChIP-Seq_EOC_Human2.92865875
4TAF15_26573619_Chip-Seq_HEK293_Human2.82457446
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78609448
6VDR_22108803_ChIP-Seq_LS180_Human2.67150267
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47466656
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45311441
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39065435
10IGF1R_20145208_ChIP-Seq_DFB_Human2.36316146
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24927966
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23554949
13P300_19829295_ChIP-Seq_ESCs_Human2.12788836
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10882659
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08255787
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07993210
17SMAD4_21799915_ChIP-Seq_A2780_Human2.07399351
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00938916
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.98180129
20FUS_26573619_Chip-Seq_HEK293_Human1.95010449
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.94623784
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93955525
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90477937
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87822709
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87753922
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86571144
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.82821166
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.81923745
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80880696
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76632500
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68314762
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65230481
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.64719647
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.64140146
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62863795
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.62664526
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62660448
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60710641
39* STAT3_23295773_ChIP-Seq_U87_Human1.56618166
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55802109
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54124977
42AR_25329375_ChIP-Seq_VCAP_Human1.53094466
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52138334
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49598167
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.48798558
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48477116
47P53_22387025_ChIP-Seq_ESCs_Mouse1.47429410
48E2F1_18555785_Chip-Seq_ESCs_Mouse1.45946037
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45826004
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45637396
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45480988
52EWS_26573619_Chip-Seq_HEK293_Human1.45441361
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45137528
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44877455
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44877455
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.44788776
57ER_23166858_ChIP-Seq_MCF-7_Human1.43446856
58CBP_20019798_ChIP-Seq_JUKART_Human1.43195188
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43195188
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41312080
61* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41212869
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40759665
63AR_21572438_ChIP-Seq_LNCaP_Human1.40387337
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39138999
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39003492
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38709596
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37854987
68BCAT_22108803_ChIP-Seq_LS180_Human1.37814461
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.37515068
70REST_21632747_ChIP-Seq_MESCs_Mouse1.37089059
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37056558
72TCF4_23295773_ChIP-Seq_U87_Human1.37012968
73IRF1_19129219_ChIP-ChIP_H3396_Human1.36209027
74TP53_22573176_ChIP-Seq_HFKS_Human1.35682619
75TCF4_22108803_ChIP-Seq_LS180_Human1.34843992
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.34838926
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.33704669
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33261686
79RUNX2_22187159_ChIP-Seq_PCA_Human1.32102413
80* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32061448
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.30467040
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30465592
83* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30166447
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28955524
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.28917450
86SOX2_19829295_ChIP-Seq_ESCs_Human1.27801556
87NANOG_19829295_ChIP-Seq_ESCs_Human1.27801556
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27076847
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.26901252
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26837420
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26594094
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26065453
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26065453
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25544458
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24922241
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24922241
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24855542
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24773625
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.23890851
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23849624
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.20862080
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20724360
103JUN_21703547_ChIP-Seq_K562_Human1.19887709
104P300_18555785_Chip-Seq_ESCs_Mouse1.19438224
105DROSHA_22980978_ChIP-Seq_HELA_Human1.19343584
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18631764
107HTT_18923047_ChIP-ChIP_STHdh_Human1.18522189
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.16656422
109RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16532857
110RNF2_27304074_Chip-Seq_NSC_Mouse1.16111262
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.14055107
112KDM2B_26808549_Chip-Seq_REH_Human1.14001329
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13942481
114FOXA1_25329375_ChIP-Seq_VCAP_Human1.13942481
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.12935026
116TP53_18474530_ChIP-ChIP_U2OS_Human1.12675809
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.11782134
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.11563362
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10819601
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.10742958
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.10702055
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10686021
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.10304579
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.09617136
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09359832
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09066516
127ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08321852
128RNF2_27304074_Chip-Seq_ESCs_Mouse1.08147528
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07427877
130POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07122085
131PU1_27457419_Chip-Seq_LIVER_Mouse1.07092366
132RXR_22158963_ChIP-Seq_LIVER_Mouse1.06923400
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04519502
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04257979
135REST_18959480_ChIP-ChIP_MESCs_Mouse1.04224770
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03110899
137NCOR_22424771_ChIP-Seq_293T_Human1.01771054
138CDX2_22108803_ChIP-Seq_LS180_Human1.00108982
139GATA3_21878914_ChIP-Seq_MCF-7_Human1.00033211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.58784479
2MP0005360_urolithiasis3.57088969
3MP0005085_abnormal_gallbladder_physiolo3.17912400
4MP0005365_abnormal_bile_salt3.09118291
5MP0003880_abnormal_central_pattern3.06298101
6MP0008875_abnormal_xenobiotic_pharmacok2.99324301
7MP0001984_abnormal_olfaction2.77546742
8MP0005646_abnormal_pituitary_gland2.71137503
9MP0004859_abnormal_synaptic_plasticity2.50747819
10MP0003635_abnormal_synaptic_transmissio2.48169130
11MP0009745_abnormal_behavioral_response2.48003804
12MP0003787_abnormal_imprinting2.45634740
13MP0002876_abnormal_thyroid_physiology2.32207120
14MP0001968_abnormal_touch/_nociception2.31976073
15MP0005423_abnormal_somatic_nervous2.29746723
16MP0002102_abnormal_ear_morphology2.25317704
17MP0009046_muscle_twitch2.21564208
18MP0002736_abnormal_nociception_after2.15227140
19MP0010386_abnormal_urinary_bladder2.13940276
20MP0002822_catalepsy2.12734660
21MP0004270_analgesia2.11273317
22MP0002063_abnormal_learning/memory/cond2.06568221
23MP0006276_abnormal_autonomic_nervous2.06566611
24MP0002572_abnormal_emotion/affect_behav2.05228431
25MP0002064_seizures2.03272898
26MP0009780_abnormal_chondrocyte_physiolo1.94135122
27MP0002272_abnormal_nervous_system1.93244570
28MP0002734_abnormal_mechanical_nocicepti1.89715394
29MP0001188_hyperpigmentation1.89369304
30MP0003252_abnormal_bile_duct1.89058111
31MP0001501_abnormal_sleep_pattern1.86181708
32MP0001529_abnormal_vocalization1.85616160
33MP0003868_abnormal_feces_composition1.83655560
34MP0000569_abnormal_digit_pigmentation1.82760132
35MP0006072_abnormal_retinal_apoptosis1.82333997
36MP0001486_abnormal_startle_reflex1.81523278
37MP0005551_abnormal_eye_electrophysiolog1.81210287
38MP0005386_behavior/neurological_phenoty1.74709041
39MP0004924_abnormal_behavior1.74709041
40MP0010329_abnormal_lipoprotein_level1.72533016
41MP0002938_white_spotting1.69166792
42MP0002067_abnormal_sensory_capabilities1.66707670
43MP0004133_heterotaxia1.62234904
44MP0009697_abnormal_copulation1.61129634
45MP0008872_abnormal_physiological_respon1.58369257
46MP0005253_abnormal_eye_physiology1.52413656
47MP0001666_abnormal_nutrient_absorption1.51041445
48MP0004142_abnormal_muscle_tone1.48993620
49MP0002653_abnormal_ependyma_morphology1.47858337
50MP0002735_abnormal_chemical_nociception1.46775545
51MP0003122_maternal_imprinting1.46724137
52MP0008789_abnormal_olfactory_epithelium1.41085258
53MP0005084_abnormal_gallbladder_morpholo1.40223691
54MP0002557_abnormal_social/conspecific_i1.39099156
55MP0001485_abnormal_pinna_reflex1.37996409
56MP0001440_abnormal_grooming_behavior1.34992843
57MP0002138_abnormal_hepatobiliary_system1.32860346
58MP0003011_delayed_dark_adaptation1.32289889
59MP0005645_abnormal_hypothalamus_physiol1.32105384
60MP0002837_dystrophic_cardiac_calcinosis1.31051254
61MP0001502_abnormal_circadian_rhythm1.27796060
62MP0001177_atelectasis1.26540744
63MP0001346_abnormal_lacrimal_gland1.23256498
64MP0005535_abnormal_body_temperature1.22824768
65MP0003646_muscle_fatigue1.20975408
66MP0002184_abnormal_innervation1.19742444
67MP0000427_abnormal_hair_cycle1.17467037
68MP0004147_increased_porphyrin_level1.15945447
69MP0002928_abnormal_bile_duct1.13240176
70MP0003283_abnormal_digestive_organ1.10714323
71MP0001970_abnormal_pain_threshold1.09717626
72MP0005408_hypopigmentation1.07576206
73MP0002090_abnormal_vision1.04736611
74MP0002752_abnormal_somatic_nervous1.04673137
75MP0005379_endocrine/exocrine_gland_phen1.04669595
76MP0005195_abnormal_posterior_eye1.03076696
77MP0003195_calcinosis1.02844164
78MP0004215_abnormal_myocardial_fiber0.99883601
79MP0002234_abnormal_pharynx_morphology0.98156600
80MP0000778_abnormal_nervous_system0.96773216
81MP0001905_abnormal_dopamine_level0.96757487
82MP0008775_abnormal_heart_ventricle0.95598797
83MP0005332_abnormal_amino_acid0.94326851
84MP0000026_abnormal_inner_ear0.94110157
85MP0002160_abnormal_reproductive_system0.94033656
86MP0002733_abnormal_thermal_nociception0.93985899
87MP0003121_genomic_imprinting0.93140048
88MP0005171_absent_coat_pigmentation0.93014855
89MP0004742_abnormal_vestibular_system0.92815013
90MP0000955_abnormal_spinal_cord0.92201152
91MP0003879_abnormal_hair_cell0.91709716
92MP0002118_abnormal_lipid_homeostasis0.89201049
93MP0005647_abnormal_sex_gland0.88933742
94MP0003119_abnormal_digestive_system0.87555548
95MP0002229_neurodegeneration0.87313526
96MP0002638_abnormal_pupillary_reflex0.85759560
97MP0003633_abnormal_nervous_system0.85098744
98MP0006054_spinal_hemorrhage0.84900517
99MP0005367_renal/urinary_system_phenotyp0.84836635
100MP0000516_abnormal_urinary_system0.84836635
101MP0000372_irregular_coat_pigmentation0.84604325
102MP0008569_lethality_at_weaning0.81929480
103MP0003137_abnormal_impulse_conducting0.81316343
104MP0004043_abnormal_pH_regulation0.80610707
105MP0008058_abnormal_DNA_repair0.80161586
106MP0001293_anophthalmia0.79808779
107MP0005499_abnormal_olfactory_system0.79574909
108MP0005394_taste/olfaction_phenotype0.79574909
109MP0001986_abnormal_taste_sensitivity0.79307190
110MP0005248_abnormal_Harderian_gland0.78261219
111MP0000383_abnormal_hair_follicle0.77900572
112MP0002882_abnormal_neuron_morphology0.77190383
113MP0004145_abnormal_muscle_electrophysio0.77051535
114MP0008877_abnormal_DNA_methylation0.74698420
115MP0002066_abnormal_motor_capabilities/c0.74398724
116MP0003136_yellow_coat_color0.73913911
117MP0002069_abnormal_eating/drinking_beha0.73233244
118MP0003890_abnormal_embryonic-extraembry0.73085806
119MP0002078_abnormal_glucose_homeostasis0.73009156
120MP0008874_decreased_physiological_sensi0.69774897
121MP0000631_abnormal_neuroendocrine_gland0.69235154
122MP0001963_abnormal_hearing_physiology0.69127475
123MP0000538_abnormal_urinary_bladder0.68984233
124MP0005187_abnormal_penis_morphology0.68507833
125MP0003631_nervous_system_phenotype0.67302363
126MP0005220_abnormal_exocrine_pancreas0.67279421
127MP0005409_darkened_coat_color0.66399857
128MP0004885_abnormal_endolymph0.66351419
129MP0004085_abnormal_heartbeat0.65750358
130MP0001764_abnormal_homeostasis0.65503885
131MP0000579_abnormal_nail_morphology0.63468622
132MP0003690_abnormal_glial_cell0.61863201
133MP0002909_abnormal_adrenal_gland0.60965479
134MP0006292_abnormal_olfactory_placode0.60921041

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.29701763
2Febrile seizures (HP:0002373)4.33491826
3Chronic hepatic failure (HP:0100626)4.09432361
4Abnormal hair whorl (HP:0010721)3.91361908
5Atonic seizures (HP:0010819)3.60160642
6Hyperventilation (HP:0002883)3.59402256
7Abnormality of the renal medulla (HP:0100957)3.44447163
8Prolonged partial thromboplastin time (HP:0003645)3.40084477
9Intrahepatic cholestasis (HP:0001406)3.38774002
10Focal seizures (HP:0007359)3.35694489
11Conjugated hyperbilirubinemia (HP:0002908)3.23106318
12Generalized tonic-clonic seizures (HP:0002069)3.20302788
13Fair hair (HP:0002286)3.15645564
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.15258487
15Abnormality of the renal cortex (HP:0011035)3.12566645
16Absence seizures (HP:0002121)3.10479787
17Congenital primary aphakia (HP:0007707)3.07864855
18Gait imbalance (HP:0002141)3.05703125
19Bile duct proliferation (HP:0001408)3.02678790
20Abnormal biliary tract physiology (HP:0012439)3.02678790
21Epileptic encephalopathy (HP:0200134)2.99864834
22Abnormal rod and cone electroretinograms (HP:0008323)2.99018201
23Cystic liver disease (HP:0006706)2.98675235
24Congenital stationary night blindness (HP:0007642)2.95660249
25Nephrogenic diabetes insipidus (HP:0009806)2.88693324
26Deep venous thrombosis (HP:0002625)2.88466672
27Generalized hypopigmentation of hair (HP:0011358)2.87613988
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87044816
29Medial flaring of the eyebrow (HP:0010747)2.86592592
30Limb dystonia (HP:0002451)2.84700237
31Hypothermia (HP:0002045)2.84512390
32Poor coordination (HP:0002370)2.83934187
33Renal cortical cysts (HP:0000803)2.78832948
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.73297688
35Progressive cerebellar ataxia (HP:0002073)2.62666792
36Dialeptic seizures (HP:0011146)2.61545067
37Abnormality of the labia minora (HP:0012880)2.61384090
38Protruding tongue (HP:0010808)2.60922653
39Pancreatic fibrosis (HP:0100732)2.58065662
40Hyperglycinemia (HP:0002154)2.55745231
41Abolished electroretinogram (ERG) (HP:0000550)2.52831425
42Tubular atrophy (HP:0000092)2.51054715
43Attenuation of retinal blood vessels (HP:0007843)2.47667852
44Gaze-evoked nystagmus (HP:0000640)2.47017097
45Decreased circulating renin level (HP:0003351)2.42551345
46Sclerocornea (HP:0000647)2.38591696
47Hypobetalipoproteinemia (HP:0003563)2.36509261
48Blue irides (HP:0000635)2.36305459
49Spontaneous abortion (HP:0005268)2.36130650
50Polyphagia (HP:0002591)2.32909807
51Polydipsia (HP:0001959)2.31069095
52Abnormal drinking behavior (HP:0030082)2.31069095
53Postaxial hand polydactyly (HP:0001162)2.30745537
54Congenital hepatic fibrosis (HP:0002612)2.30162135
55Hypochromic microcytic anemia (HP:0004840)2.30130416
56Molar tooth sign on MRI (HP:0002419)2.28759519
57Abnormality of midbrain morphology (HP:0002418)2.28759519
58Abnormality of the right ventricle (HP:0001707)2.27838552
59Abnormality of the common coagulation pathway (HP:0010990)2.27591372
60Papillary thyroid carcinoma (HP:0002895)2.27302360
61Drooling (HP:0002307)2.26931346
62Excessive salivation (HP:0003781)2.26931346
63True hermaphroditism (HP:0010459)2.26327348
64Abnormal ciliary motility (HP:0012262)2.26280332
65Broad-based gait (HP:0002136)2.26145518
66Genital tract atresia (HP:0001827)2.25283137
67Chorioretinal atrophy (HP:0000533)2.24828587
68Anencephaly (HP:0002323)2.24795878
69Impaired vibration sensation in the lower limbs (HP:0002166)2.22871807
70Abnormality of methionine metabolism (HP:0010901)2.22423347
71Increased corneal curvature (HP:0100692)2.21071912
72Keratoconus (HP:0000563)2.21071912
73Thyroid-stimulating hormone excess (HP:0002925)2.20067900
74Myokymia (HP:0002411)2.17397073
75Postaxial foot polydactyly (HP:0001830)2.17234037
76Labial hypoplasia (HP:0000066)2.16293177
77Type II lissencephaly (HP:0007260)2.15940100
78Epidermoid cyst (HP:0200040)2.15085160
79Lip pit (HP:0100267)2.14970461
80Acute hepatic failure (HP:0006554)2.14921312
81Agitation (HP:0000713)2.13366354
82Vaginal atresia (HP:0000148)2.13268191
83Mitochondrial inheritance (HP:0001427)2.12603308
84Decreased central vision (HP:0007663)2.12481686
85Dynein arm defect of respiratory motile cilia (HP:0012255)2.12345894
86Absent/shortened dynein arms (HP:0200106)2.12345894
87Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12010936
88Male pseudohermaphroditism (HP:0000037)2.11226130
89Genetic anticipation (HP:0003743)2.10354086
90Abnormal respiratory motile cilium physiology (HP:0012261)2.09357478
91Abnormal respiratory motile cilium morphology (HP:0005938)2.09063518
92Abnormal respiratory epithelium morphology (HP:0012253)2.09063518
933-Methylglutaconic aciduria (HP:0003535)2.08519632
94Impaired vibratory sensation (HP:0002495)2.08453476
95Hyperlipoproteinemia (HP:0010980)2.06503530
96Furrowed tongue (HP:0000221)2.05902893
97Neoplasm of the tracheobronchial system (HP:0100552)2.05619130
98Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05290917
99Joint hemorrhage (HP:0005261)2.05289235
100Increased CSF lactate (HP:0002490)2.03150887
101Alveolar cell carcinoma (HP:0006519)2.01967417
102Colon cancer (HP:0003003)2.01692908
103Fat malabsorption (HP:0002630)2.01545226
104Epileptiform EEG discharges (HP:0011182)2.00850750
105Symptomatic seizures (HP:0011145)2.00567859
106Abnormality of sulfur amino acid metabolism (HP:0004339)2.00051188
107Acute encephalopathy (HP:0006846)1.97755455
108Status epilepticus (HP:0002133)1.97068976
109Abnormality of serine family amino acid metabolism (HP:0010894)1.96051045
110Abnormality of glycine metabolism (HP:0010895)1.96051045
111Abnormality of macular pigmentation (HP:0008002)1.95641246
112Lissencephaly (HP:0001339)1.94997275
113Hyperglycinuria (HP:0003108)1.94360760
114Hepatic necrosis (HP:0002605)1.94279166
115Progressive macrocephaly (HP:0004481)1.92808791
116Narrow forehead (HP:0000341)1.91439326
117Preaxial hand polydactyly (HP:0001177)1.90931406
118Hemiparesis (HP:0001269)1.90844877
119Inability to walk (HP:0002540)1.89643409
120Polyuria (HP:0000103)1.89173217
121Torticollis (HP:0000473)1.88241547
122Tubulointerstitial nephritis (HP:0001970)1.87597083
123Hepatocellular necrosis (HP:0001404)1.87170551
124Progressive inability to walk (HP:0002505)1.86686685
125EEG with generalized epileptiform discharges (HP:0011198)1.86632563
126Urinary bladder sphincter dysfunction (HP:0002839)1.86433243
127Prostate neoplasm (HP:0100787)1.86301205
128Visual hallucinations (HP:0002367)1.85944621
129Retinitis pigmentosa (HP:0000510)1.85370927
130Pancreatic cysts (HP:0001737)1.84979353
131Intestinal atresia (HP:0011100)1.84733050
132Methylmalonic aciduria (HP:0012120)1.84231319
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.83977369
134Short tibia (HP:0005736)1.83862404
135Stomach cancer (HP:0012126)1.82578999
136Glycosuria (HP:0003076)1.82505169
137Abnormality of urine glucose concentration (HP:0011016)1.82505169
138Supernumerary spleens (HP:0009799)1.82455225
139Methylmalonic acidemia (HP:0002912)1.81847692
140Hypoglycemic seizures (HP:0002173)1.81602837
141Oligomenorrhea (HP:0000876)1.81599820
142Complement deficiency (HP:0004431)1.80858555
143Occipital encephalocele (HP:0002085)1.80676816
144Ketosis (HP:0001946)1.80075555
145Specific learning disability (HP:0001328)1.79976481
146Optic nerve hypoplasia (HP:0000609)1.79393867
147Aplasia/Hypoplasia of the lens (HP:0008063)1.79034540
148Absent speech (HP:0001344)1.78511144
149Hypolipoproteinemia (HP:0010981)1.78185977
150Proximal tubulopathy (HP:0000114)1.77211445
151Hypoplastic female external genitalia (HP:0012815)1.75527081
152Broad foot (HP:0001769)1.75173753
153Large for gestational age (HP:0001520)1.74311146
154Central scotoma (HP:0000603)1.72329946
155Abnormality of the intrinsic pathway (HP:0010989)1.72299326
156Cerebral palsy (HP:0100021)1.72178270
157Scanning speech (HP:0002168)1.70697152
158Nephronophthisis (HP:0000090)1.69392009
159Papilledema (HP:0001085)1.67615109
160Acute necrotizing encephalopathy (HP:0006965)1.67169833
161Hypsarrhythmia (HP:0002521)1.66364273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.48164590
2WNK33.29865093
3CASK3.25774265
4MAP2K72.96762264
5MAP3K42.88856667
6NTRK32.81577245
7MAP2K42.65557687
8MAP3K122.56124783
9EPHA42.48220300
10FRK2.39833600
11TNIK2.32914498
12BMPR1B2.21346377
13SGK22.19242521
14ACVR1B2.11587158
15SIK32.01677691
16INSRR1.97349802
17MAPK131.93360028
18BCKDK1.86669192
19AKT31.79416421
20MAP3K61.74354672
21PHKG21.65453886
22PHKG11.65453886
23MUSK1.63722955
24BMPR21.59102176
25TRIM281.56705750
26PRPF4B1.55679511
27STK38L1.54374638
28WNK41.54153861
29PLK21.53092456
30MINK11.50128802
31LATS11.48960287
32OXSR11.45785565
33SGK2231.43797669
34SGK4941.43797669
35SGK31.42470084
36ERBB41.35788135
37ERBB31.33711615
38STK391.32713834
39GRK71.28104063
40DYRK21.25879737
41CDK31.20239032
42DAPK21.19717286
43KSR11.13340183
44ADRBK21.13298943
45BCR1.10865924
46TAOK31.10114677
47NEK61.01764238
48STK160.98837283
49CAMK2A0.98791512
50PRKCG0.98149364
51MKNK20.98086406
52MAP3K130.96680373
53CDK190.96436648
54NUAK10.95622316
55PIK3CA0.93282538
56NTRK20.90975063
57SIK20.90164948
58MST40.89725204
59PIK3CG0.88401717
60PRKCE0.88244615
61PINK10.87980733
62SGK10.87074874
63TIE10.84388822
64GRK50.84104597
65OBSCN0.81904198
66BRAF0.80270026
67PRKCH0.78373313
68YES10.76929498
69SIK10.75731634
70CSNK1G20.73399691
71TXK0.72634491
72RIPK40.71550613
73TNK20.71010875
74IRAK30.69860682
75RPS6KB10.68556823
76STK240.68237381
77MARK10.67432213
78MAP3K140.65661849
79PNCK0.63826794
80PASK0.63589029
81CDK80.63532899
82ARAF0.62104762
83DAPK10.61679724
84ADRBK10.61400052
85FLT30.60016492
86STK380.59447021
87MST1R0.59130764
88DYRK30.58996954
89MKNK10.57944172
90MAP3K50.57872280
91PLK30.56504090
92FER0.56166362
93GRK10.56085023
94STK110.55252652
95CAMK10.54744213
96CAMK2G0.54635471
97TGFBR10.54601820
98JAK10.54479051
99PRKG10.50703766
100VRK10.49370301
101CSNK1G10.48995648
102FGFR20.48543758
103CDK50.48016671
104CSNK1A10.47575014
105CSNK1A1L0.47251517
106PKN10.46645272
107PRKCQ0.46475946
108MAPK150.46358170
109CSNK1G30.45244670
110WNK10.45027595
111DYRK1A0.44787931
112RET0.44691932
113TEC0.44657432
114LATS20.44476590
115PTK2B0.44392578
116PAK30.44228663
117IRAK10.44046042
118CAMK2B0.43550282
119EPHB20.42079964
120CAMK2D0.41531042
121PRKACB0.41018275
122MAP3K90.40981030
123MAP3K70.40616284
124ZAK0.40082366
125PRKACA0.40046458
126MAP3K20.39979610
127MAP2K10.39746411
128IRAK20.39213568
129UHMK10.38848125
130RPS6KA30.38395550
131STK30.38371440
132CAMKK20.37812343
133PRKCZ0.37743864
134PLK40.37677817
135PRKCA0.37266572
136PRKAA10.36468028
137NEK90.35560814
138TLK10.32470230
139CSNK1D0.30215503
140PRKAA20.29639745
141EIF2AK30.28661322
142PAK60.27320960
143CCNB10.26830030
144BRSK20.25947165

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36672031
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.85571826
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19421543
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19111498
5GABAergic synapse_Homo sapiens_hsa047272.19037795
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17015314
7Linoleic acid metabolism_Homo sapiens_hsa005912.03456399
8Olfactory transduction_Homo sapiens_hsa047402.00130242
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92243790
10Sulfur metabolism_Homo sapiens_hsa009201.89738046
11Parkinsons disease_Homo sapiens_hsa050121.88449043
12Butanoate metabolism_Homo sapiens_hsa006501.86141475
13Morphine addiction_Homo sapiens_hsa050321.85499183
14Phototransduction_Homo sapiens_hsa047441.84685246
15Synaptic vesicle cycle_Homo sapiens_hsa047211.83994799
16Arginine biosynthesis_Homo sapiens_hsa002201.79646538
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75297864
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74338262
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73933567
20Taste transduction_Homo sapiens_hsa047421.73128844
21Circadian entrainment_Homo sapiens_hsa047131.69316800
22Tryptophan metabolism_Homo sapiens_hsa003801.64751573
23Glutamatergic synapse_Homo sapiens_hsa047241.63091527
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.62637272
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62453011
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55014372
27Insulin secretion_Homo sapiens_hsa049111.52190600
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51702470
29Ether lipid metabolism_Homo sapiens_hsa005651.50908900
30Amphetamine addiction_Homo sapiens_hsa050311.49403696
31Nitrogen metabolism_Homo sapiens_hsa009101.45431482
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42786637
33Serotonergic synapse_Homo sapiens_hsa047261.42632710
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41798769
35Collecting duct acid secretion_Homo sapiens_hsa049661.39746519
36Cardiac muscle contraction_Homo sapiens_hsa042601.38616782
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37186682
38Complement and coagulation cascades_Homo sapiens_hsa046101.35542592
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35008753
40Chemical carcinogenesis_Homo sapiens_hsa052041.34087916
41Dopaminergic synapse_Homo sapiens_hsa047281.32030830
42Regulation of autophagy_Homo sapiens_hsa041401.31509037
43Peroxisome_Homo sapiens_hsa041461.30212639
44Huntingtons disease_Homo sapiens_hsa050161.29802534
45Alzheimers disease_Homo sapiens_hsa050101.29274192
46Basal transcription factors_Homo sapiens_hsa030221.28552055
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28139088
48Fatty acid degradation_Homo sapiens_hsa000711.27775325
49Propanoate metabolism_Homo sapiens_hsa006401.25601877
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25072680
51Retinol metabolism_Homo sapiens_hsa008301.23414245
52Circadian rhythm_Homo sapiens_hsa047101.22256935
53Starch and sucrose metabolism_Homo sapiens_hsa005001.18577687
54Histidine metabolism_Homo sapiens_hsa003401.18316335
55Long-term potentiation_Homo sapiens_hsa047201.14411249
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13612383
57Cholinergic synapse_Homo sapiens_hsa047251.13000775
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12009864
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.11489707
60Renin secretion_Homo sapiens_hsa049241.11213109
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09912723
62Type II diabetes mellitus_Homo sapiens_hsa049301.08695438
63beta-Alanine metabolism_Homo sapiens_hsa004101.07566434
64Selenocompound metabolism_Homo sapiens_hsa004501.06966562
65ABC transporters_Homo sapiens_hsa020101.01274294
66Calcium signaling pathway_Homo sapiens_hsa040201.00869330
67RNA polymerase_Homo sapiens_hsa030200.98119771
68Steroid biosynthesis_Homo sapiens_hsa001000.97458537
69RNA degradation_Homo sapiens_hsa030180.94645325
70Tyrosine metabolism_Homo sapiens_hsa003500.94270078
71Salivary secretion_Homo sapiens_hsa049700.92767826
72Fatty acid metabolism_Homo sapiens_hsa012120.91840790
73PPAR signaling pathway_Homo sapiens_hsa033200.91526003
74Cocaine addiction_Homo sapiens_hsa050300.91431974
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89117022
76Long-term depression_Homo sapiens_hsa047300.88522580
77Bile secretion_Homo sapiens_hsa049760.88331452
78Ovarian steroidogenesis_Homo sapiens_hsa049130.87724207
79Fat digestion and absorption_Homo sapiens_hsa049750.86445882
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85778031
81Arachidonic acid metabolism_Homo sapiens_hsa005900.79130815
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78072094
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77359059
84Homologous recombination_Homo sapiens_hsa034400.77157100
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76351057
86Lysine degradation_Homo sapiens_hsa003100.76275684
87Fanconi anemia pathway_Homo sapiens_hsa034600.73343974
88Metabolic pathways_Homo sapiens_hsa011000.71302124
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.71275093
90Fatty acid elongation_Homo sapiens_hsa000620.70639883
91Phenylalanine metabolism_Homo sapiens_hsa003600.70078302
92cAMP signaling pathway_Homo sapiens_hsa040240.69358059
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67634282
94Pyruvate metabolism_Homo sapiens_hsa006200.66875324
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64924340
96Caffeine metabolism_Homo sapiens_hsa002320.64153393
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64107435
98GnRH signaling pathway_Homo sapiens_hsa049120.64066282
99Oxytocin signaling pathway_Homo sapiens_hsa049210.63996597
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61793338
101Vitamin digestion and absorption_Homo sapiens_hsa049770.61716364
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60195647
103Fatty acid biosynthesis_Homo sapiens_hsa000610.58168198
104Gastric acid secretion_Homo sapiens_hsa049710.58033872
105Mineral absorption_Homo sapiens_hsa049780.56550581
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54760407
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54668046
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53031774
109Vibrio cholerae infection_Homo sapiens_hsa051100.52928602
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49512610
111Purine metabolism_Homo sapiens_hsa002300.48967589
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48849421
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47005751
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46607869
115Non-homologous end-joining_Homo sapiens_hsa034500.46423165
116Arginine and proline metabolism_Homo sapiens_hsa003300.45967555
117Glucagon signaling pathway_Homo sapiens_hsa049220.45448896
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44470066
119Glycerolipid metabolism_Homo sapiens_hsa005610.43539975
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.42114709
121One carbon pool by folate_Homo sapiens_hsa006700.40901316
122ErbB signaling pathway_Homo sapiens_hsa040120.39311143
123Hedgehog signaling pathway_Homo sapiens_hsa043400.39225813
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38525952
125Pancreatic secretion_Homo sapiens_hsa049720.37076530
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.37076098
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34286250
128Protein export_Homo sapiens_hsa030600.34271644
129Sphingolipid metabolism_Homo sapiens_hsa006000.32823329
130Axon guidance_Homo sapiens_hsa043600.32626928
131Oxidative phosphorylation_Homo sapiens_hsa001900.31114621
132Folate biosynthesis_Homo sapiens_hsa007900.31016254

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