RNF145

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)4.86414808
2hemidesmosome assembly (GO:0031581)4.72953788
3positive regulation of histone deacetylation (GO:0031065)4.18147270
4negative regulation of cell killing (GO:0031342)4.04200491
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04200491
6pre-miRNA processing (GO:0031054)3.96308492
7regulation of gamma-delta T cell differentiation (GO:0045586)3.92304112
8COPI coating of Golgi vesicle (GO:0048205)3.81091364
9Golgi transport vesicle coating (GO:0048200)3.81091364
10cell adhesion mediated by integrin (GO:0033627)3.72635859
11positive regulation of gamma-delta T cell activation (GO:0046645)3.68273350
12positive T cell selection (GO:0043368)3.67375120
13positive thymic T cell selection (GO:0045059)3.66969082
14cytoskeletal anchoring at plasma membrane (GO:0007016)3.61657855
15chemical homeostasis within a tissue (GO:0048875)3.55265156
16negative T cell selection (GO:0043383)3.54003516
17peptidyl-lysine dimethylation (GO:0018027)3.50623155
18dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.44450595
19hypotonic response (GO:0006971)3.37935309
20regulation of gamma-delta T cell activation (GO:0046643)3.35479074
21T cell selection (GO:0045058)3.29586939
22negative thymic T cell selection (GO:0045060)3.28657707
23thymic T cell selection (GO:0045061)3.25721569
24skin morphogenesis (GO:0043589)3.20906825
25sodium ion export (GO:0071436)3.20319672
26regulation of early endosome to late endosome transport (GO:2000641)3.10643515
27negative regulation of histone methylation (GO:0031061)3.09891096
28positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.08987024
29cell-substrate junction assembly (GO:0007044)3.08544704
30regulation of vitamin D biosynthetic process (GO:0060556)3.07402285
31locomotory exploration behavior (GO:0035641)3.02454919
32response to laminar fluid shear stress (GO:0034616)2.99492443
33layer formation in cerebral cortex (GO:0021819)2.98262341
34cytoplasmic mRNA processing body assembly (GO:0033962)2.95686621
35negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.93673480
36epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92965264
37regulation of podosome assembly (GO:0071801)2.91083677
38lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86826070
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86446089
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86446089
41regulation of ARF GTPase activity (GO:0032312)2.84999247
42regulation of ARF protein signal transduction (GO:0032012)2.84952456
43antigen processing and presentation of endogenous antigen (GO:0019883)2.81176673
44synaptic vesicle maturation (GO:0016188)2.80830470
45planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78429443
46insulin-like growth factor receptor signaling pathway (GO:0048009)2.78202947
47signal complex assembly (GO:0007172)2.78179032
48positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74316747
49negative regulation of erythrocyte differentiation (GO:0045647)2.74005442
50histone H3-K9 demethylation (GO:0033169)2.73188143
51barbed-end actin filament capping (GO:0051016)2.72376289
52positive regulation of Rap GTPase activity (GO:0032854)2.71985127
53response to interleukin-15 (GO:0070672)2.70224221
54positive regulation of protein deacetylation (GO:0090312)2.69697106
55negative regulation of interleukin-12 production (GO:0032695)2.69602869
56negative regulation of anoikis (GO:2000811)2.68712708
57protein localization to endosome (GO:0036010)2.68670592
58cortical actin cytoskeleton organization (GO:0030866)2.65941119
59natural killer cell differentiation (GO:0001779)2.64858211
60stress granule assembly (GO:0034063)2.64258458
61positive regulation by symbiont of host defense response (GO:0052509)2.64256357
62modulation by symbiont of host defense response (GO:0052031)2.64256357
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64256357
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64256357
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.64256357
66modulation by symbiont of host immune response (GO:0052553)2.64256357
67endodermal cell differentiation (GO:0035987)2.63951439
68regulation of chromatin binding (GO:0035561)2.62985915
69response to muramyl dipeptide (GO:0032495)2.62944238
70response to peptidoglycan (GO:0032494)2.62280070
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61824868
72regulation of defense response to virus by virus (GO:0050690)2.59474871
73modulation by symbiont of host cellular process (GO:0044068)2.57656765
74regulation of clathrin-mediated endocytosis (GO:2000369)2.57182799
75positive regulation of tolerance induction (GO:0002645)2.56168192
76activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.55381348
77regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55331909
78regulation of T cell tolerance induction (GO:0002664)2.53236922
79glucocorticoid receptor signaling pathway (GO:0042921)2.52722770
80establishment of nucleus localization (GO:0040023)2.52617823
81substrate-dependent cell migration (GO:0006929)2.51269038
82regulation of Rap GTPase activity (GO:0032317)2.50766106
83positive regulation of Cdc42 GTPase activity (GO:0043089)2.50086373
84regulation of anoikis (GO:2000209)2.48990889
85macrophage activation involved in immune response (GO:0002281)2.48208870
86iron ion import (GO:0097286)2.48083743
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47731315
88positive regulation of nuclease activity (GO:0032075)2.47662710
89T cell costimulation (GO:0031295)2.47133972
90positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.46138936
91regulation of RNA export from nucleus (GO:0046831)2.45537550
92retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.45422511
93cellular potassium ion homeostasis (GO:0030007)2.45305299
94positive regulation of RNA splicing (GO:0033120)2.44989008
95regulation of vitamin metabolic process (GO:0030656)2.43880737
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42650616
97negative regulation of cell size (GO:0045792)2.42541413
98semaphorin-plexin signaling pathway (GO:0071526)2.42210831
99mesodermal cell differentiation (GO:0048333)2.41528323
100lymphocyte costimulation (GO:0031294)2.40915671
101vesicle coating (GO:0006901)2.39824532
102histone H3-K36 demethylation (GO:0070544)2.39813345
103endothelial cell chemotaxis (GO:0035767)2.39483194
104regulation of translational fidelity (GO:0006450)2.37866666
105NLS-bearing protein import into nucleus (GO:0006607)2.37672135
106regulation of membrane protein ectodomain proteolysis (GO:0051043)2.37606824
107positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.37354702
108regulation of short-term neuronal synaptic plasticity (GO:0048172)2.37290245
109positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.35928652
110activated T cell proliferation (GO:0050798)2.35871031
111detection of molecule of bacterial origin (GO:0032490)2.35725108
112epithelial cell-cell adhesion (GO:0090136)2.35671601
113T cell receptor signaling pathway (GO:0050852)2.35592046
114regulation of histone deacetylation (GO:0031063)2.34908235
115positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.34494399
116embryonic process involved in female pregnancy (GO:0060136)2.34462763
117glial cell proliferation (GO:0014009)2.33937498
118regulation of nucleobase-containing compound transport (GO:0032239)2.33866598
119stress fiber assembly (GO:0043149)2.33170571
120NIK/NF-kappaB signaling (GO:0038061)2.32966115
121germinal center formation (GO:0002467)2.32667238
122apoptotic cell clearance (GO:0043277)2.32279775
123regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.31954137
124regulation of NFAT protein import into nucleus (GO:0051532)2.31577908
125response to vitamin D (GO:0033280)2.31185596
126adherens junction assembly (GO:0034333)2.30676602
127positive regulation of receptor recycling (GO:0001921)2.30612026
128regulation of type I interferon-mediated signaling pathway (GO:0060338)2.30403367
129clathrin coat assembly (GO:0048268)2.30049558
130peptidyl-threonine modification (GO:0018210)2.26702655
131membrane protein ectodomain proteolysis (GO:0006509)2.26653890
132dorsal/ventral axis specification (GO:0009950)2.25897049
133JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.25845496
134nerve growth factor signaling pathway (GO:0038180)2.25649736
135cellular response to vitamin D (GO:0071305)2.24923802
136negative regulation of fatty acid transport (GO:2000192)2.24593629
137T-helper 1 type immune response (GO:0042088)2.23947623
138activation of protein kinase A activity (GO:0034199)2.23310190
139regulation of nuclease activity (GO:0032069)2.22603224
140histone H4-K16 acetylation (GO:0043984)2.21847289
141detection of other organism (GO:0098543)2.21375468
142cellular response to thyroid hormone stimulus (GO:0097067)2.21023807
143B cell receptor signaling pathway (GO:0050853)2.20401752
144nuclear pore complex assembly (GO:0051292)2.19430095
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.19246124
146positive regulation of cellular amide metabolic process (GO:0034250)2.19210142
147negative regulation of GTPase activity (GO:0034260)2.18688338
148negative regulation of GTP catabolic process (GO:0033125)2.18688338
149positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.18341487
150activation of Rac GTPase activity (GO:0032863)2.18039191
151peptidyl-threonine phosphorylation (GO:0018107)2.17844715
152membrane raft organization (GO:0031579)2.16954334
153G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.16407841
154activation of JUN kinase activity (GO:0007257)2.15313480
155cortical cytoskeleton organization (GO:0030865)2.14635545
156cell-substrate adherens junction assembly (GO:0007045)2.14248277
157focal adhesion assembly (GO:0048041)2.14248277
158cellular response to virus (GO:0098586)2.14137184
159histone H3-K4 methylation (GO:0051568)2.13138996
160regulation of growth hormone secretion (GO:0060123)2.13092082
161histone lysine demethylation (GO:0070076)2.12538427
162receptor catabolic process (GO:0032801)2.12205239
163positive regulation of blood vessel endothelial cell migration (GO:0043536)2.11891496
164corticosteroid receptor signaling pathway (GO:0031958)2.11505106
165positive regulation of p38MAPK cascade (GO:1900745)2.11363009
166positive regulation of endothelial cell apoptotic process (GO:2000353)2.11014144
167establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.10880955
168antigen receptor-mediated signaling pathway (GO:0050851)2.10850619
169endocytic recycling (GO:0032456)2.10734848
170regulation of transforming growth factor beta2 production (GO:0032909)2.10565815
171regulation of glucose import in response to insulin stimulus (GO:2001273)2.10354822
172vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.10286695
173histone H2A monoubiquitination (GO:0035518)2.10164300
174negative regulation of type 2 immune response (GO:0002829)2.09746824
175regulation of tolerance induction (GO:0002643)2.09370986
176polarized epithelial cell differentiation (GO:0030859)2.09237408
177positive regulation of astrocyte differentiation (GO:0048711)2.09044531
178regulation of protein deacetylation (GO:0090311)2.09038557
179basement membrane organization (GO:0071711)2.08533823
180detection of external biotic stimulus (GO:0098581)2.08509427
181positive regulation of transcription factor import into nucleus (GO:0042993)2.06765806
182activation of MAPKKK activity (GO:0000185)2.05857753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.78333860
2MYC_22102868_ChIP-Seq_BL_Human4.18124113
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.13592126
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.40549072
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.32992807
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02791882
7* KDM2B_26808549_Chip-Seq_DND41_Human2.96250628
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.82197420
9KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.79855173
10TCF7_22412390_ChIP-Seq_EML_Mouse2.68756521
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.52602170
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50644234
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42725598
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41931505
15VDR_21846776_ChIP-Seq_THP-1_Human2.41006134
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.38251607
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35437611
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.31076162
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.30793596
20KDM2B_26808549_Chip-Seq_JURKAT_Human2.27103048
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26121439
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.23476290
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23249914
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20457662
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.16807009
26UTX_26944678_Chip-Seq_JUKART_Human2.12099278
27KDM2B_26808549_Chip-Seq_K562_Human2.11397579
28* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.10672685
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08331221
30DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.08329335
31* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08253999
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.03328892
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00582069
34MAF_26560356_Chip-Seq_TH1_Human1.97878150
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.95048161
36CLOCK_20551151_ChIP-Seq_293T_Human1.91817460
37* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88738457
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87593162
39RUNX_20019798_ChIP-Seq_JUKART_Human1.82307812
40P300_27058665_Chip-Seq_ZR-75-30cells_Human1.77187159
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75797013
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75797013
43LXR_22292898_ChIP-Seq_THP-1_Human1.70667802
44* RARB_27405468_Chip-Seq_BRAIN_Mouse1.67246437
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66252979
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.65744010
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65072477
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.63797865
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63649281
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63335723
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62953961
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62259044
53* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62139169
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61946699
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61690812
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.60412169
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59710763
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59001143
59MYB_26560356_Chip-Seq_TH2_Human1.58566207
60GATA1_19941826_ChIP-Seq_K562_Human1.55034015
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.50825893
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50712546
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50504167
64CIITA_25753668_ChIP-Seq_RAJI_Human1.49292727
65* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48127375
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.47419428
67VDR_24763502_ChIP-Seq_THP-1_Human1.43170783
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43142803
69* UBF1/2_26484160_Chip-Seq_HMECs_Human1.43054772
70CREB1_26743006_Chip-Seq_LNCaP_Human1.42217344
71RACK7_27058665_Chip-Seq_MCF-7_Human1.39402166
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39027596
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39006530
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38079641
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36863634
76FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.36715307
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.35351216
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34311100
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34062216
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30722527
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.30262610
82* SPI1_23127762_ChIP-Seq_K562_Human1.29516571
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.29274381
84MYB_26560356_Chip-Seq_TH1_Human1.28914999
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27331677
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26848006
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25155461
88MAF_26560356_Chip-Seq_TH2_Human1.24841682
89SCL_19346495_ChIP-Seq_HPC-7_Human1.24834077
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23702851
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.23519073
92* NCOR1_26117541_ChIP-Seq_K562_Human1.23367048
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.22974506
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22063537
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21026434
96* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18946505
97* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18161854
98* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17926124
99TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17664987
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17215920
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16257414
102DROSHA_22980978_ChIP-Seq_HELA_Human1.15763457
103* CHD1_26751641_Chip-Seq_LNCaP_Human1.15149659
104GATA3_27048872_Chip-Seq_THYMUS_Human1.13700273
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08358757
106TBX20_22080862_ChIP-Seq_HEART_Mouse1.08188942
107TBX20_22328084_ChIP-Seq_HEART_Mouse1.08188942
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07582655
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07581422
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.07176319
111ZNF263_19887448_ChIP-Seq_K562_Human1.06965369
112GATA1_19941827_ChIP-Seq_MEL_Mouse1.05839027
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04581896
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03691579
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02801101
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02387411
117PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01928811
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.00777984
119TP53_22127205_ChIP-Seq_IMR90_Human0.99445882
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99406458
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99329863
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98747387
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98392516
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98055502
125* PU_27001747_Chip-Seq_BMDM_Mouse0.96805977
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96690700
127AR_21909140_ChIP-Seq_LNCAP_Human0.96303555
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92525167
129GATA1_22025678_ChIP-Seq_K562_Human0.92060549
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90679650
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90173970
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89821554
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89259758
134NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88981371
135* ATF3_27146783_Chip-Seq_COLON_Human0.88381019
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88241596
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88039739
138RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86516088
139GATA2_19941826_ChIP-Seq_K562_Human0.85811387
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.85534873
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84007565
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83913821
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83340523
144* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82971404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.27971802
2MP0005076_abnormal_cell_differentiation2.90526050
3MP0010234_abnormal_vibrissa_follicle2.90109243
4MP0003705_abnormal_hypodermis_morpholog2.75496497
5MP0004859_abnormal_synaptic_plasticity2.65987067
6MP0003453_abnormal_keratinocyte_physiol2.61146428
7MP0008438_abnormal_cutaneous_collagen2.57008158
8MP0008961_abnormal_basal_metabolism2.55209174
9MP0002909_abnormal_adrenal_gland2.55112301
10MP0003436_decreased_susceptibility_to2.34479037
11MP0010352_gastrointestinal_tract_polyps2.25048878
12MP0003303_peritoneal_inflammation2.23090582
13MP0003763_abnormal_thymus_physiology2.22591635
14MP0005058_abnormal_lysosome_morphology2.21892407
15MP0000685_abnormal_immune_system1.96446869
16MP0005257_abnormal_intraocular_pressure1.95762112
17MP0005023_abnormal_wound_healing1.93192729
18MP0000569_abnormal_digit_pigmentation1.90224283
19MP0003191_abnormal_cellular_cholesterol1.86408551
20MP0000537_abnormal_urethra_morphology1.86368007
21MP0001849_ear_inflammation1.82326664
22MP0000579_abnormal_nail_morphology1.82325599
23MP0000858_altered_metastatic_potential1.82253948
24MP0004782_abnormal_surfactant_physiolog1.78590106
25MP0005409_darkened_coat_color1.78493343
26MP0003045_fibrosis1.75811471
27MP0004272_abnormal_basement_membrane1.74865685
28MP0002653_abnormal_ependyma_morphology1.74705940
29MP0003448_altered_tumor_morphology1.74581098
30MP0003122_maternal_imprinting1.72814495
31MP0003283_abnormal_digestive_organ1.71503548
32MP0002877_abnormal_melanocyte_morpholog1.67165310
33MP0000703_abnormal_thymus_morphology1.65303860
34MP0006054_spinal_hemorrhage1.63920166
35MP0003724_increased_susceptibility_to1.62653938
36MP0009780_abnormal_chondrocyte_physiolo1.61015045
37MP0002166_altered_tumor_susceptibility1.59397839
38MP0005451_abnormal_body_composition1.56526428
39MP0009278_abnormal_bone_marrow1.55287862
40MP0008260_abnormal_autophagy1.54362002
41MP0002060_abnormal_skin_morphology1.53384560
42MP0003828_pulmonary_edema1.53383534
43MP0000013_abnormal_adipose_tissue1.51931730
44MP0003172_abnormal_lysosome_physiology1.50913745
45MP0002998_abnormal_bone_remodeling1.49265626
46MP0005275_abnormal_skin_tensile1.48488610
47MP0003787_abnormal_imprinting1.48441921
48MP0003183_abnormal_peptide_metabolism1.46456493
49MP0002419_abnormal_innate_immunity1.43650633
50MP0006072_abnormal_retinal_apoptosis1.39695547
51MP0006082_CNS_inflammation1.39158410
52MP0000003_abnormal_adipose_tissue1.38438828
53MP0002398_abnormal_bone_marrow1.36934348
54MP0003123_paternal_imprinting1.36843636
55MP0001533_abnormal_skeleton_physiology1.35416819
56MP0002148_abnormal_hypersensitivity_rea1.34062451
57MP0004947_skin_inflammation1.33575122
58MP0008004_abnormal_stomach_pH1.33076867
59MP0003091_abnormal_cell_migration1.32433932
60MP0009785_altered_susceptibility_to1.31893031
61MP0004885_abnormal_endolymph1.31358187
62MP0004808_abnormal_hematopoietic_stem1.29623770
63MP0003075_altered_response_to1.29126183
64MP0004858_abnormal_nervous_system1.29021705
65MP0003121_genomic_imprinting1.28769188
66MP0001216_abnormal_epidermal_layer1.27964608
67MP0001851_eye_inflammation1.27713290
68MP0003635_abnormal_synaptic_transmissio1.26517344
69MP0005000_abnormal_immune_tolerance1.25061766
70MP0004185_abnormal_adipocyte_glucose1.24737202
71MP0001835_abnormal_antigen_presentation1.22944183
72MP0000733_abnormal_muscle_development1.22459253
73MP0009840_abnormal_foam_cell1.20974665
74MP0005025_abnormal_response_to1.20730402
75MP0000428_abnormal_craniofacial_morphol1.19884574
76MP0002796_impaired_skin_barrier1.19660046
77MP0005387_immune_system_phenotype1.18998592
78MP0001790_abnormal_immune_system1.18998592
79MP0000604_amyloidosis1.18587297
80MP0010155_abnormal_intestine_physiology1.16689784
81MP0003279_aneurysm1.15659390
82MP0001800_abnormal_humoral_immune1.15377249
83MP0004233_abnormal_muscle_weight1.15040738
84MP0004510_myositis1.13847042
85MP0002084_abnormal_developmental_patter1.09733360
86MP0008770_decreased_survivor_rate1.09207979
87MP0005164_abnormal_response_to1.08587710
88MP0001299_abnormal_eye_distance/1.05930623
89MP0005187_abnormal_penis_morphology1.04800159
90MP0002089_abnormal_postnatal_growth/wei1.04798291
91MP0003941_abnormal_skin_development1.04713540
92MP0001958_emphysema1.04015729
93MP0001853_heart_inflammation1.03833696
94MP0002234_abnormal_pharynx_morphology1.03659593
95MP0003890_abnormal_embryonic-extraembry1.02679546
96MP0009053_abnormal_anal_canal1.01286623
97MP0002722_abnormal_immune_system1.01197955
98MP0005375_adipose_tissue_phenotype1.00763412
99MP0004197_abnormal_fetal_growth/weight/1.00759714
100MP0010678_abnormal_skin_adnexa1.00507039
101MP0001944_abnormal_pancreas_morphology0.99851671
102MP0002006_tumorigenesis0.99471763
103MP0003566_abnormal_cell_adhesion0.98699468
104MP0004811_abnormal_neuron_physiology0.98480661
105MP0000762_abnormal_tongue_morphology0.98358567
106MP0002133_abnormal_respiratory_system0.98156784
107MP0005388_respiratory_system_phenotype0.98156784
108MP0001348_abnormal_lacrimal_gland0.97797642
109MP0000343_altered_response_to0.97490267
110MP0008569_lethality_at_weaning0.96858612
111MP0003866_abnormal_defecation0.95379736
112MP0000716_abnormal_immune_system0.93346862
113MP0002925_abnormal_cardiovascular_devel0.93319841
114MP0000767_abnormal_smooth_muscle0.92787619
115MP0003329_amyloid_beta_deposits0.92786816
116MP0005671_abnormal_response_to0.91179738
117MP0005621_abnormal_cell_physiology0.90438827
118MP0001915_intracranial_hemorrhage0.90382831
119MP0002420_abnormal_adaptive_immunity0.90131405
120MP0005623_abnormal_meninges_morphology0.90048911
121MP0002723_abnormal_immune_serum0.89748193
122MP0002697_abnormal_eye_size0.89371391
123MP0000689_abnormal_spleen_morphology0.89227387
124MP0003119_abnormal_digestive_system0.88741470
125MP0004270_analgesia0.88280819
126MP0002092_abnormal_eye_morphology0.86737508
127MP0000490_abnormal_crypts_of0.86187631
128MP0001819_abnormal_immune_cell0.86151354
129MP0001879_abnormal_lymphatic_vessel0.85446047
130MP0003690_abnormal_glial_cell0.85053594
131MP0005390_skeleton_phenotype0.84285419
132MP0001542_abnormal_bone_strength0.84218631
133MP0005501_abnormal_skin_physiology0.84051870
134MP0002896_abnormal_bone_mineralization0.83157259
135MP0010368_abnormal_lymphatic_system0.83115960
136MP0002086_abnormal_extraembryonic_tissu0.82842929
137MP0005166_decreased_susceptibility_to0.82630876
138MP0003634_abnormal_glial_cell0.82388979
139MP0009703_decreased_birth_body0.82108934
140MP0003861_abnormal_nervous_system0.81968382
141MP0005165_increased_susceptibility_to0.81857065
142MP0002933_joint_inflammation0.80574538
143MP0003115_abnormal_respiratory_system0.80451425
144MP0010307_abnormal_tumor_latency0.79754630
145MP0000350_abnormal_cell_proliferation0.79602651
146MP0002168_other_aberrant_phenotype0.78903761
147MP0003656_abnormal_erythrocyte_physiolo0.78730301
148MP0009333_abnormal_splenocyte_physiolog0.78529967
149MP0001730_embryonic_growth_arrest0.78389526
150MP0002429_abnormal_blood_cell0.78204493
151MP0005197_abnormal_uvea_morphology0.76952536
152MP0002085_abnormal_embryonic_tissue0.76842601
153MP0001545_abnormal_hematopoietic_system0.76352094
154MP0005397_hematopoietic_system_phenotyp0.76352094
155MP0002452_abnormal_antigen_presenting0.74742069
156MP0001845_abnormal_inflammatory_respons0.74287943
157MP0002152_abnormal_brain_morphology0.72843557
158MP0000778_abnormal_nervous_system0.72800284
159MP0001784_abnormal_fluid_regulation0.72083005
160MP0000955_abnormal_spinal_cord0.72070986
161MP0002405_respiratory_system_inflammati0.71068388
162MP0005394_taste/olfaction_phenotype0.70735797
163MP0005499_abnormal_olfactory_system0.70735797
164MP0002063_abnormal_learning/memory/cond0.70419507
165MP0001697_abnormal_embryo_size0.70394495

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)3.63968955
2Macroorchidism (HP:0000053)3.57378976
3Premature rupture of membranes (HP:0001788)3.50985590
4Hyperacusis (HP:0010780)3.33459395
5Neurofibrillary tangles (HP:0002185)3.32830568
6Cerebral aneurysm (HP:0004944)3.30004457
7Milia (HP:0001056)3.09805977
8Insomnia (HP:0100785)2.94087730
9Eczematoid dermatitis (HP:0000976)2.75280598
10Abnormality of liposaccharide metabolism (HP:0010968)2.72873878
11Abnormality of glycosphingolipid metabolism (HP:0004343)2.72873878
12Abnormality of glycolipid metabolism (HP:0010969)2.72873878
13T lymphocytopenia (HP:0005403)2.69926887
14Aortic aneurysm (HP:0004942)2.67905956
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.64172346
16Thick nail (HP:0001805)2.60746916
17Osteolytic defects of the hand bones (HP:0009699)2.59437818
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.59437818
19Fragile skin (HP:0001030)2.59413564
20Vertebral compression fractures (HP:0002953)2.53747036
21Vertebral arch anomaly (HP:0008438)2.52539513
22Neoplasm of the heart (HP:0100544)2.50502955
23Abnormality of the fingertips (HP:0001211)2.50179110
24Abnormality of T cell number (HP:0011839)2.43739626
25Resting tremor (HP:0002322)2.41711635
26Heterotopia (HP:0002282)2.40279486
27Abnormality of oral frenula (HP:0000190)2.37948900
28Elfin facies (HP:0004428)2.33590555
29Shallow orbits (HP:0000586)2.30270399
30Mitral valve prolapse (HP:0001634)2.28960564
31Fragile nails (HP:0001808)2.28756780
32Dilatation of the ascending aorta (HP:0005111)2.27098356
33Striae distensae (HP:0001065)2.26746358
34Pointed chin (HP:0000307)2.21816102
35Ankyloglossia (HP:0010296)2.20491559
36Abnormality of macrophages (HP:0004311)2.20447827
37Subacute progressive viral hepatitis (HP:0006572)2.19738073
38Renal duplication (HP:0000075)2.18219680
39Onycholysis (HP:0001806)2.17959713
40Recurrent bronchitis (HP:0002837)2.16935795
41Broad face (HP:0000283)2.12432754
42Bowel diverticulosis (HP:0005222)2.10669887
43Nuclear cataract (HP:0100018)2.10470605
44Gingivitis (HP:0000230)2.09405342
45Deep palmar crease (HP:0006191)2.09043094
46Verrucae (HP:0200043)2.08776691
47Papilloma (HP:0012740)2.08776691
48Short nail (HP:0001799)2.08574262
49Arterial tortuosity (HP:0005116)2.07730784
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07701108
51Short 4th metacarpal (HP:0010044)2.07701108
52Recurrent bacterial skin infections (HP:0005406)2.06767183
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04674356
54Overriding aorta (HP:0002623)2.03323713
55Recurrent abscess formation (HP:0002722)2.01194556
56Abnormality of the distal phalanx of the thumb (HP:0009617)2.01102009
57Loss of speech (HP:0002371)2.01077080
58Aneurysm (HP:0002617)2.00294883
59Cervical subluxation (HP:0003308)1.98164468
60Obsessive-compulsive behavior (HP:0000722)1.97915815
61Panhypogammaglobulinemia (HP:0003139)1.97476486
62Abnormality of the distal phalanges of the toes (HP:0010182)1.97304060
63Segmental peripheral demyelination/remyelination (HP:0003481)1.97119268
64Peritonitis (HP:0002586)1.96605733
65Spinal cord lesions (HP:0100561)1.95547427
66Syringomyelia (HP:0003396)1.95547427
67Hand muscle atrophy (HP:0009130)1.94532566
68Renovascular hypertension (HP:0100817)1.93727037
69Increased density of long bones (HP:0006392)1.93391163
70Abnormality of nail color (HP:0100643)1.92720672
71Wormian bones (HP:0002645)1.92354770
72Abnormality of the astrocytes (HP:0100707)1.89195821
73Astrocytoma (HP:0009592)1.89195821
74Ridged nail (HP:0001807)1.88900967
75Distal upper limb amyotrophy (HP:0007149)1.88657365
76Upper limb amyotrophy (HP:0009129)1.88657365
77Natal tooth (HP:0000695)1.88537642
78Abnormality of the nasal mucosa (HP:0000433)1.88063179
79Nail dystrophy (HP:0008404)1.87456599
80Recurrent viral infections (HP:0004429)1.87076811
81Spondylolisthesis (HP:0003302)1.86690350
82Flat acetabular roof (HP:0003180)1.85989346
83Enlarged penis (HP:0000040)1.85520517
84Vascular tortuosity (HP:0004948)1.84218941
85Cellulitis (HP:0100658)1.83876322
86Blue sclerae (HP:0000592)1.78895359
87Interstitial pulmonary disease (HP:0006530)1.76495485
88Thin bony cortex (HP:0002753)1.76371508
89Trigonocephaly (HP:0000243)1.76323279
90Genu recurvatum (HP:0002816)1.76316377
91Obstructive sleep apnea (HP:0002870)1.76181424
92Cerebral inclusion bodies (HP:0100314)1.75648408
93Persistence of primary teeth (HP:0006335)1.75371731
94Dysostosis multiplex (HP:0000943)1.74822409
95Plantar hyperkeratosis (HP:0007556)1.74102386
96Hypercortisolism (HP:0001578)1.74059265
97Abnormality of the lower motor neuron (HP:0002366)1.73998379
98Narrow palate (HP:0000189)1.73592806
99Buphthalmos (HP:0000557)1.73534306
100Broad palm (HP:0001169)1.73215376
101Hematochezia (HP:0002573)1.73079773
102Long toe (HP:0010511)1.72834566
103Ependymoma (HP:0002888)1.72800385
104Selective tooth agenesis (HP:0001592)1.72379339
105Abnormal blistering of the skin (HP:0008066)1.72368201
106Basal cell carcinoma (HP:0002671)1.72215277
107Posterior subcapsular cataract (HP:0007787)1.71712535
108Hyperparathyroidism (HP:0000843)1.71341456
109Aqueductal stenosis (HP:0002410)1.71077083
110Volvulus (HP:0002580)1.70269406
111Bladder diverticulum (HP:0000015)1.70251587
112Depression (HP:0000716)1.69827148
113Ulnar bowing (HP:0003031)1.69656874
114Upper motor neuron abnormality (HP:0002127)1.68354002
115Spontaneous hematomas (HP:0007420)1.68278424
116Termporal pattern (HP:0011008)1.67996849
117Insidious onset (HP:0003587)1.67996849
118Orchitis (HP:0100796)1.67783314
119Increased nuchal translucency (HP:0010880)1.67701806
120Achilles tendon contracture (HP:0001771)1.67671076
121Supranuclear gaze palsy (HP:0000605)1.67518934
122Bicuspid aortic valve (HP:0001647)1.67127596
123Cupped ribs (HP:0000887)1.66192602
124Disproportionate tall stature (HP:0001519)1.64851435
125Apathy (HP:0000741)1.63736317
126Thyroiditis (HP:0100646)1.63297993
127Nasal polyposis (HP:0100582)1.63292826
128Absent frontal sinuses (HP:0002688)1.63166591
129Hypoventilation (HP:0002791)1.62014786
130Papilledema (HP:0001085)1.61729769
131Amyotrophic lateral sclerosis (HP:0007354)1.61575082
132Pelvic girdle muscle weakness (HP:0003749)1.61262798
133Emphysema (HP:0002097)1.61253254
134Sacral dimple (HP:0000960)1.60271542
135Abnormal ossification of hand bones (HP:0005921)1.59862731
136Long palpebral fissure (HP:0000637)1.58908924
137Postural tremor (HP:0002174)1.58291737
138Protrusio acetabuli (HP:0003179)1.57930754
139Truncal ataxia (HP:0002078)1.57801030
140Truncal obesity (HP:0001956)1.57671143
141Arnold-Chiari malformation (HP:0002308)1.57179510
142Asymmetry of the thorax (HP:0001555)1.56444544
143Periodontitis (HP:0000704)1.56419654
144Ankle contracture (HP:0006466)1.56371924
145Myositis (HP:0100614)1.55384377
146Aortic dissection (HP:0002647)1.55286918
147Viral hepatitis (HP:0006562)1.55046497
148Neuronal loss in central nervous system (HP:0002529)1.54771362
149Impaired smooth pursuit (HP:0007772)1.54440225
150Combined immunodeficiency (HP:0005387)1.54387148
151Aplasia cutis congenita (HP:0001057)1.53748796
152Amyloidosis (HP:0011034)1.53719890
153Severe combined immunodeficiency (HP:0004430)1.53657892
154Increased connective tissue (HP:0009025)1.53639714
155Disinhibition (HP:0000734)1.53620837
156Broad thumb (HP:0011304)1.53061640
157Diminished motivation (HP:0000745)1.53007023
158Bone pain (HP:0002653)1.52860664
159Frequent falls (HP:0002359)1.52475973
160Colitis (HP:0002583)1.52464440
161Visual hallucinations (HP:0002367)1.52438339
162Broad metatarsal (HP:0001783)1.52010282
163Fibrous tissue neoplasm (HP:0012316)1.51302618
164Hypoplasia of the thymus (HP:0000778)1.51263122
165Abnormality of dentin (HP:0010299)1.51130874
166Mediastinal lymphadenopathy (HP:0100721)1.50933106
167Aseptic necrosis (HP:0010885)1.50588473
168Abnormality of the 4th metacarpal (HP:0010012)1.50396470
169Action tremor (HP:0002345)1.50345087
170Increased cerebral lipofuscin (HP:0011813)1.50301279
171Mitral regurgitation (HP:0001653)1.49809534
172Hallux valgus (HP:0001822)1.49487063
173Joint laxity (HP:0001388)1.46854230
174Pathologic fracture (HP:0002756)1.46246326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.57811240
2MAP3K103.41533353
3PRPF4B3.23196071
4EEF2K3.18813263
5PKN22.99384163
6IRAK32.88750395
7MAP4K12.49350439
8LATS22.49289287
9CDK122.38551597
10MST1R2.37647730
11MAP3K142.10237015
12SMG12.05733319
13PDGFRA1.87572079
14RIPK11.77429583
15SIK21.76147239
16PTK61.76091535
17KSR21.75841701
18SIK11.74773963
19TYRO31.72882100
20MOS1.68350388
21ERN11.66285597
22LRRK21.64619608
23GRK61.63670557
24ALK1.59826717
25STK101.57596753
26MET1.57391433
27RET1.52927520
28TAOK21.51243265
29MAP3K31.48165445
30PRKCH1.44423196
31MAP3K91.42852666
32ARAF1.41230945
33ITK1.39634442
34KSR11.39119279
35PDGFRB1.38935754
36FGFR41.37860270
37CAMK1G1.37262856
38EPHA21.30036593
39HIPK21.28799051
40SCYL21.27991582
41FGR1.27616432
42NME21.25683863
43FGFR21.23229744
44FGFR31.19375780
45MAP3K11.15016703
46MAP2K31.14257618
47PAK61.14165727
48JAK11.13678768
49CAMK1D1.09663659
50NTRK31.07498305
51MAP3K21.07313753
52DYRK1B1.06154485
53NTRK11.05721177
54ICK1.04780210
55ZAP701.04136532
56JAK31.03743459
57STK241.02792938
58TESK11.02586496
59TAOK11.00999870
60PTK21.00429229
61UHMK10.99316813
62MAP3K70.96347967
63FGFR10.94647336
64BRD40.93373324
65PRKD30.93239418
66YES10.91670216
67PASK0.91187338
68TGFBR20.91144230
69TBK10.90101472
70MTOR0.89870244
71HCK0.86847904
72MAP3K130.86833595
73IRAK40.83021463
74SIK30.82778215
75ERBB40.79836011
76BMX0.79233059
77PAK30.78604959
78NEK90.78034293
79JAK20.78005580
80CDC42BPA0.75818583
81CSK0.75810620
82MARK20.75462618
83TYK20.73826708
84NEK20.72866190
85MAP3K60.72576908
86MARK30.71891714
87IRAK20.71466420
88CDK60.70975224
89EPHA30.70973710
90MAP3K40.70199119
91MELK0.69926412
92WNK10.69841287
93GRK70.67907610
94CLK10.67052107
95TTN0.66357043
96NTRK20.65786680
97EPHB10.64961805
98ACVR1B0.64411477
99SYK0.64295647
100MAP3K110.63857562
101DAPK20.63650735
102EPHB20.62901310
103BLK0.62003150
104RPS6KA40.61922035
105PRKD20.61267714
106LCK0.60437510
107CAMKK10.60300520
108PAK20.59315547
109MATK0.59273634
110FYN0.58559072
111TGFBR10.57987712
112RIPK40.56756422
113ROCK20.55849562
114EPHA40.55821135
115INSR0.52647020
116BTK0.51714573
117DDR20.51553259
118RPS6KA20.51308823
119STK380.50999941
120IRAK10.50124429
121CDK50.50104994
122ERBB20.49400407
123TRPM70.49302921
124STK110.48077952
125DMPK0.47286454
126CSF1R0.46983862
127LATS10.45966835
128CDK40.45364499
129PDK10.44757461
130SGK30.44208703
131SRC0.43409949
132MAP3K80.43045222
133PIM20.42879537
134EGFR0.42252910
135PAK40.41746207
136WNK30.40988112
137PRKD10.40168473
138MARK10.39356199
139PDPK10.38767187
140RPS6KC10.36478357
141RPS6KL10.36478357
142IKBKE0.35409160

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01840569
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.93984137
3Primary immunodeficiency_Homo sapiens_hsa053401.91468945
4Chronic myeloid leukemia_Homo sapiens_hsa052201.69764433
5T cell receptor signaling pathway_Homo sapiens_hsa046601.68925640
6Malaria_Homo sapiens_hsa051441.65649216
7Other glycan degradation_Homo sapiens_hsa005111.64784722
8B cell receptor signaling pathway_Homo sapiens_hsa046621.63510937
9Amoebiasis_Homo sapiens_hsa051461.63490322
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62120345
11Leishmaniasis_Homo sapiens_hsa051401.57219071
12mTOR signaling pathway_Homo sapiens_hsa041501.57167972
13TNF signaling pathway_Homo sapiens_hsa046681.51717717
14Prion diseases_Homo sapiens_hsa050201.51260389
15Colorectal cancer_Homo sapiens_hsa052101.50321709
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46744139
17Salmonella infection_Homo sapiens_hsa051321.46635183
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44664069
19Long-term potentiation_Homo sapiens_hsa047201.38512350
20Non-small cell lung cancer_Homo sapiens_hsa052231.38148877
21ECM-receptor interaction_Homo sapiens_hsa045121.36182727
22Glioma_Homo sapiens_hsa052141.36155623
23Endometrial cancer_Homo sapiens_hsa052131.35874758
24Type II diabetes mellitus_Homo sapiens_hsa049301.35211832
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.34997850
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.33994950
27Pancreatic cancer_Homo sapiens_hsa052121.32257339
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31343519
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28294475
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26504976
31Lysosome_Homo sapiens_hsa041421.25862649
32VEGF signaling pathway_Homo sapiens_hsa043701.25637012
33Pertussis_Homo sapiens_hsa051331.22941385
34Renal cell carcinoma_Homo sapiens_hsa052111.20409161
35Tuberculosis_Homo sapiens_hsa051521.19363778
36Estrogen signaling pathway_Homo sapiens_hsa049151.17572651
37Hepatitis C_Homo sapiens_hsa051601.16410028
38Influenza A_Homo sapiens_hsa051641.15994567
39Measles_Homo sapiens_hsa051621.15026966
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14379974
41Apoptosis_Homo sapiens_hsa042101.12248759
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12096064
43Dorso-ventral axis formation_Homo sapiens_hsa043201.11260013
44Insulin secretion_Homo sapiens_hsa049111.10731955
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10037456
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09932559
47Proteoglycans in cancer_Homo sapiens_hsa052051.09338158
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08172292
49Dopaminergic synapse_Homo sapiens_hsa047281.06702427
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06078023
51Prolactin signaling pathway_Homo sapiens_hsa049171.05972658
52Gastric acid secretion_Homo sapiens_hsa049711.05485083
53Acute myeloid leukemia_Homo sapiens_hsa052211.05437504
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03729975
55Phagosome_Homo sapiens_hsa041451.03341308
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03088621
57Legionellosis_Homo sapiens_hsa051341.02659695
58ErbB signaling pathway_Homo sapiens_hsa040121.00756380
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.00260381
60Adherens junction_Homo sapiens_hsa045200.99888475
61Osteoclast differentiation_Homo sapiens_hsa043800.99861020
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98060265
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97828895
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.97334021
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.97156409
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.97147148
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96855586
68Endocytosis_Homo sapiens_hsa041440.95255766
69Cholinergic synapse_Homo sapiens_hsa047250.94682722
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.94569030
71Chemokine signaling pathway_Homo sapiens_hsa040620.94092373
72Platelet activation_Homo sapiens_hsa046110.93521230
73Salivary secretion_Homo sapiens_hsa049700.92731482
74MicroRNAs in cancer_Homo sapiens_hsa052060.92680494
75Focal adhesion_Homo sapiens_hsa045100.91506012
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90544294
77Viral myocarditis_Homo sapiens_hsa054160.89839679
78Renin secretion_Homo sapiens_hsa049240.89611470
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89504653
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89174740
81Choline metabolism in cancer_Homo sapiens_hsa052310.89029476
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88953304
83GnRH signaling pathway_Homo sapiens_hsa049120.87964665
84Circadian entrainment_Homo sapiens_hsa047130.87736103
85Olfactory transduction_Homo sapiens_hsa047400.87162275
86Oxytocin signaling pathway_Homo sapiens_hsa049210.87094406
87Insulin resistance_Homo sapiens_hsa049310.86428655
88Notch signaling pathway_Homo sapiens_hsa043300.86208022
89African trypanosomiasis_Homo sapiens_hsa051430.86175608
90Cocaine addiction_Homo sapiens_hsa050300.86150874
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.86114302
92Antigen processing and presentation_Homo sapiens_hsa046120.85856170
93Gap junction_Homo sapiens_hsa045400.85822179
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85482892
95Axon guidance_Homo sapiens_hsa043600.85084488
96Bladder cancer_Homo sapiens_hsa052190.83565546
97Rap1 signaling pathway_Homo sapiens_hsa040150.83092201
98Herpes simplex infection_Homo sapiens_hsa051680.82798938
99Small cell lung cancer_Homo sapiens_hsa052220.82683012
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82674980
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82163615
102HTLV-I infection_Homo sapiens_hsa051660.82088646
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81818117
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80922504
105Pathways in cancer_Homo sapiens_hsa052000.80676504
106Hematopoietic cell lineage_Homo sapiens_hsa046400.80410815
107Amphetamine addiction_Homo sapiens_hsa050310.80387284
108Synaptic vesicle cycle_Homo sapiens_hsa047210.80178526
109Hepatitis B_Homo sapiens_hsa051610.79461414
110MAPK signaling pathway_Homo sapiens_hsa040100.79097105
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78986383
112Rheumatoid arthritis_Homo sapiens_hsa053230.78789855
113Toxoplasmosis_Homo sapiens_hsa051450.78486855
114Thyroid cancer_Homo sapiens_hsa052160.78114466
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78014750
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77795792
117Hippo signaling pathway_Homo sapiens_hsa043900.77641050
118Staphylococcus aureus infection_Homo sapiens_hsa051500.77581700
119Lysine degradation_Homo sapiens_hsa003100.77405408
120Glutamatergic synapse_Homo sapiens_hsa047240.77053503
121Allograft rejection_Homo sapiens_hsa053300.76606456
122Morphine addiction_Homo sapiens_hsa050320.75926135
123GABAergic synapse_Homo sapiens_hsa047270.75280062
124Insulin signaling pathway_Homo sapiens_hsa049100.74929271
125Thyroid hormone synthesis_Homo sapiens_hsa049180.73268637
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71495796
127Melanogenesis_Homo sapiens_hsa049160.69743212
128Viral carcinogenesis_Homo sapiens_hsa052030.69499885
129Shigellosis_Homo sapiens_hsa051310.69185475
130HIF-1 signaling pathway_Homo sapiens_hsa040660.69149123
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69003258
132FoxO signaling pathway_Homo sapiens_hsa040680.68882957
133Prostate cancer_Homo sapiens_hsa052150.68357918
134Wnt signaling pathway_Homo sapiens_hsa043100.68300495
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67584057
136cAMP signaling pathway_Homo sapiens_hsa040240.67493795
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67008719
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66281532
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63923825
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59211900
141Autoimmune thyroid disease_Homo sapiens_hsa053200.58184344
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56008401
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.55775646
144Inositol phosphate metabolism_Homo sapiens_hsa005620.53231588

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