RNF144B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.08683281
2L-phenylalanine catabolic process (GO:0006559)6.08683281
3L-phenylalanine metabolic process (GO:0006558)5.76224560
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.76224560
5aromatic amino acid family catabolic process (GO:0009074)5.54297757
6complement activation, alternative pathway (GO:0006957)5.53732655
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50203064
8alpha-linolenic acid metabolic process (GO:0036109)5.28591090
9kynurenine metabolic process (GO:0070189)5.24130043
10regulation of protein activation cascade (GO:2000257)5.23172944
11bile acid biosynthetic process (GO:0006699)5.16624555
12indole-containing compound catabolic process (GO:0042436)5.16061482
13indolalkylamine catabolic process (GO:0046218)5.16061482
14tryptophan catabolic process (GO:0006569)5.16061482
15peptidyl-glutamic acid carboxylation (GO:0017187)5.14074147
16protein carboxylation (GO:0018214)5.14074147
17response to peptidoglycan (GO:0032494)5.12799057
18urea metabolic process (GO:0019627)5.06692002
19urea cycle (GO:0000050)5.06692002
20high-density lipoprotein particle remodeling (GO:0034375)4.97378299
21regulation of complement activation (GO:0030449)4.96601767
22negative regulation of fibrinolysis (GO:0051918)4.96012206
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86074707
24tryptophan metabolic process (GO:0006568)4.82580958
25sulfur amino acid catabolic process (GO:0000098)4.79859122
26negative regulation of interleukin-12 production (GO:0032695)4.78548840
27regulation of triglyceride catabolic process (GO:0010896)4.73283069
28regulation of fibrinolysis (GO:0051917)4.72765811
29glyoxylate metabolic process (GO:0046487)4.68984758
30macrophage activation involved in immune response (GO:0002281)4.65204987
31cysteine metabolic process (GO:0006534)4.63138867
32nitrogen cycle metabolic process (GO:0071941)4.60189234
33reverse cholesterol transport (GO:0043691)4.43617216
34bile acid metabolic process (GO:0008206)4.42707384
35phospholipid efflux (GO:0033700)4.35247595
36triglyceride homeostasis (GO:0070328)4.34754362
37acylglycerol homeostasis (GO:0055090)4.34754362
38plasma lipoprotein particle remodeling (GO:0034369)4.27961420
39protein-lipid complex remodeling (GO:0034368)4.27961420
40macromolecular complex remodeling (GO:0034367)4.27961420
41plasma lipoprotein particle clearance (GO:0034381)4.24601234
42serine family amino acid catabolic process (GO:0009071)4.24467641
43amino-acid betaine metabolic process (GO:0006577)4.23308099
44positive regulation by symbiont of host defense response (GO:0052509)4.22695575
45modulation by symbiont of host defense response (GO:0052031)4.22695575
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.22695575
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.22695575
48positive regulation by organism of defense response of other organism involved in symbiotic interact4.22695575
49modulation by symbiont of host immune response (GO:0052553)4.22695575
50neutrophil activation involved in immune response (GO:0002283)4.18789523
51regulation of cholesterol esterification (GO:0010872)4.16397002
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.14020061
53regulation of interferon-beta biosynthetic process (GO:0045357)4.07935316
54lysine metabolic process (GO:0006553)4.04871723
55lysine catabolic process (GO:0006554)4.04871723
56regulation of interferon-alpha production (GO:0032647)4.04316605
57lipopolysaccharide-mediated signaling pathway (GO:0031663)4.01989382
58detection of molecule of bacterial origin (GO:0032490)4.00653821
59positive regulation of gamma-delta T cell activation (GO:0046645)4.00200615
60homocysteine metabolic process (GO:0050667)3.97909371
61ethanol oxidation (GO:0006069)3.92768291
62phospholipid homeostasis (GO:0055091)3.90739193
63alpha-amino acid catabolic process (GO:1901606)3.90557482
64aromatic amino acid family metabolic process (GO:0009072)3.89707841
65bile acid and bile salt transport (GO:0015721)3.88701947
66fibrinolysis (GO:0042730)3.87774412
67dicarboxylic acid biosynthetic process (GO:0043650)3.83867513
68negative regulation of lipase activity (GO:0060192)3.83542532
69glutamate metabolic process (GO:0006536)3.82526387
70positive regulation of interferon-alpha production (GO:0032727)3.81709006
71cholesterol efflux (GO:0033344)3.80592448
72immunoglobulin mediated immune response (GO:0016064)3.79231248
73positive regulation of lipid catabolic process (GO:0050996)3.76850479
74tyrosine metabolic process (GO:0006570)3.76368031
75regulation of T-helper 1 cell differentiation (GO:0045625)3.75064284
76negative regulation of cholesterol transport (GO:0032375)3.72048228
77negative regulation of sterol transport (GO:0032372)3.72048228
78germinal center formation (GO:0002467)3.70089591
79complement activation (GO:0006956)3.69744087
80regulation of vitamin D biosynthetic process (GO:0060556)3.66172193
81cellular ketone body metabolic process (GO:0046950)3.65048601
82complement activation, classical pathway (GO:0006958)3.62704532
83cellular amino acid catabolic process (GO:0009063)3.61111866
84positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.60635740
85regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.59667306
86detection of other organism (GO:0098543)3.58118232
87cellular modified amino acid catabolic process (GO:0042219)3.58034031
88benzene-containing compound metabolic process (GO:0042537)3.57826285
89protein activation cascade (GO:0072376)3.56902278
90positive regulation of lipoprotein lipase activity (GO:0051006)3.56628971
91positive regulation of triglyceride lipase activity (GO:0061365)3.56628971
92positive regulation of fatty acid beta-oxidation (GO:0032000)3.56554287
93indolalkylamine metabolic process (GO:0006586)3.52491240
94type I interferon signaling pathway (GO:0060337)3.52397045
95cellular response to type I interferon (GO:0071357)3.52397045
96macrophage activation (GO:0042116)3.52016951
97plasma lipoprotein particle assembly (GO:0034377)3.51646962
98coenzyme catabolic process (GO:0009109)3.50237791
99low-density lipoprotein particle remodeling (GO:0034374)3.47850131
100response to type I interferon (GO:0034340)3.47369175
101cytolysis (GO:0019835)3.47248752
102cellular glucuronidation (GO:0052695)3.45419211
103cellular biogenic amine catabolic process (GO:0042402)3.44403893
104amine catabolic process (GO:0009310)3.44403893
105regulation of cholesterol homeostasis (GO:2000188)3.41673811
106microglial cell activation (GO:0001774)3.40655265
107cholesterol homeostasis (GO:0042632)3.39954841
108positive regulation of type 2 immune response (GO:0002830)3.39024715
109fatty acid oxidation (GO:0019395)3.39005745
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38796250
111negative regulation of cell killing (GO:0031342)3.38796250
112detection of external biotic stimulus (GO:0098581)3.37590809
1132-oxoglutarate metabolic process (GO:0006103)3.37467968
114fatty acid beta-oxidation (GO:0006635)3.36325285
115sterol homeostasis (GO:0055092)3.35684879
116imidazole-containing compound metabolic process (GO:0052803)3.35505813
117acetyl-CoA metabolic process (GO:0006084)3.33842900
118short-chain fatty acid metabolic process (GO:0046459)3.33400228
119lipid oxidation (GO:0034440)3.32453261
120T-helper 1 type immune response (GO:0042088)3.32409749
121regulation of dendritic cell antigen processing and presentation (GO:0002604)3.31809672
122acute-phase response (GO:0006953)3.30979821
123carnitine metabolic process (GO:0009437)3.30640786
124interferon-gamma-mediated signaling pathway (GO:0060333)3.28606278
125organic acid catabolic process (GO:0016054)3.27855625
126carboxylic acid catabolic process (GO:0046395)3.27855625
127regulation of T-helper 2 cell differentiation (GO:0045628)3.27557402
128blood coagulation, intrinsic pathway (GO:0007597)3.27511594
129negative regulation of protein activation cascade (GO:2000258)3.27394779
130monocarboxylic acid catabolic process (GO:0072329)3.27149183
131plasma lipoprotein particle organization (GO:0071827)3.27117767
132fatty acid transmembrane transport (GO:1902001)3.26201511
133defense response to protozoan (GO:0042832)3.22804845
134fatty acid catabolic process (GO:0009062)3.22712357
135arginine metabolic process (GO:0006525)3.22553538
136cellular extravasation (GO:0045123)3.22068180
137response to nitrosative stress (GO:0051409)3.21268731
138lipoprotein metabolic process (GO:0042157)3.20756185
139detection of bacterium (GO:0016045)3.20119993
140protein-lipid complex assembly (GO:0065005)3.19672911
141positive regulation of toll-like receptor signaling pathway (GO:0034123)3.19096838
142response to muramyl dipeptide (GO:0032495)3.18880615
143regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.18236881
144positive regulation of interferon-beta production (GO:0032728)3.17527523
145response to protozoan (GO:0001562)3.12619097
146granulocyte activation (GO:0036230)3.11058198
147regulation of interleukin-8 biosynthetic process (GO:0045414)3.07778501
148myeloid cell activation involved in immune response (GO:0002275)3.07169576
149regulation of gamma-delta T cell activation (GO:0046643)3.06512765
150neutrophil activation (GO:0042119)3.03055779
151detection of biotic stimulus (GO:0009595)3.02740152
152production of molecular mediator involved in inflammatory response (GO:0002532)2.99884297
153antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99026303
154response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98864905
155response to host immune response (GO:0052572)2.98864905
156negative regulation of cytokine production involved in immune response (GO:0002719)2.96649554
157positive regulation of NF-kappaB import into nucleus (GO:0042346)2.94688534
158B cell mediated immunity (GO:0019724)2.93303650
159positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90579375
160positive regulation of chemokine biosynthetic process (GO:0045080)2.89117622
161regulation of interleukin-12 production (GO:0032655)2.86176079
162regulation of antigen processing and presentation (GO:0002577)2.83210147
163regulation of germinal center formation (GO:0002634)2.82199990
164regulation of podosome assembly (GO:0071801)2.82130196
165positive regulation of interleukin-6 production (GO:0032755)2.82076387
166positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79864620
167regulation of T-helper cell differentiation (GO:0045622)2.78963859
168response to host (GO:0075136)2.78895245
169response to host defenses (GO:0052200)2.78895245
170response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.78895245
171regulation of vitamin metabolic process (GO:0030656)2.76348881
172positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75212834
173positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.74918391
174regulation of type 2 immune response (GO:0002828)2.72914278
175negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.70991564
176positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.70726960
177positive regulation of interleukin-1 beta secretion (GO:0050718)2.69814526
178regulation of chemokine biosynthetic process (GO:0045073)2.68690121
179negative regulation of T cell mediated immunity (GO:0002710)2.68444407
180regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.68118929
181antigen processing and presentation of endogenous antigen (GO:0019883)2.67924353
182negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.65957822
183negative regulation of T-helper cell differentiation (GO:0045623)2.65957822
184cellular response to molecule of bacterial origin (GO:0071219)2.65869949
185regulation of interferon-beta production (GO:0032648)2.65332166
186positive regulation of T-helper cell differentiation (GO:0045624)2.65291742
187positive regulation of interleukin-10 production (GO:0032733)2.63939334
188cellular response to lipopolysaccharide (GO:0071222)2.63653172
189neutrophil mediated immunity (GO:0002446)2.63512575
190positive regulation of heat generation (GO:0031652)2.63244806
191regulation of tolerance induction (GO:0002643)2.63189303
192antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62919698
193positive regulation of nitric oxide biosynthetic process (GO:0045429)2.62217714
194positive regulation of antigen processing and presentation (GO:0002579)2.61087607
195regulation of membrane protein ectodomain proteolysis (GO:0051043)2.59506056
196positive regulation of acute inflammatory response (GO:0002675)2.58207242
197positive regulation of interleukin-1 secretion (GO:0050716)2.56964787
198cellular response to interferon-gamma (GO:0071346)2.56920934
199positive regulation of chemokine production (GO:0032722)2.55104592
200leukocyte aggregation (GO:0070486)2.55031073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.13792967
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.46605336
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.64585245
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.32195234
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.05086594
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.99978374
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.87368972
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.29630544
9IRF8_21731497_ChIP-ChIP_J774_Mouse4.01254758
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61919564
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.46007379
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.34912182
13SMAD_19615063_ChIP-ChIP_OVARY_Human3.03410345
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.00220064
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81130605
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74432262
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59778127
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56465617
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.42353949
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11329411
21RUNX_20019798_ChIP-Seq_JUKART_Human2.09933857
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.01287716
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95570561
24SPI1_23127762_ChIP-Seq_K562_Human1.80682742
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76372902
26CLOCK_20551151_ChIP-Seq_293T_Human1.74563721
27* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74500690
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70818148
29SPI1_23547873_ChIP-Seq_NB4_Human1.70024933
30SCL_19346495_ChIP-Seq_HPC-7_Human1.68708660
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64866176
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.64506611
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63522844
34GATA1_22025678_ChIP-Seq_K562_Human1.61453872
35* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60324257
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59254936
37VDR_24763502_ChIP-Seq_THP-1_Human1.57134113
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53255309
39* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50544280
40* MYB_26560356_Chip-Seq_TH2_Human1.46925279
41PU_27001747_Chip-Seq_BMDM_Mouse1.46597001
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45848158
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45759816
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44085337
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.36763178
46ZNF263_19887448_ChIP-Seq_K562_Human1.35829100
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34367199
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30156147
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.30003099
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29804349
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29538995
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28697919
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27205593
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26170047
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.21095821
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.21037460
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20154656
58MYB_26560356_Chip-Seq_TH1_Human1.17910362
59* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17076686
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16961312
61* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14474724
62* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14474724
63MAF_26560356_Chip-Seq_TH1_Human1.13752196
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.12874532
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11591332
66GATA3_26560356_Chip-Seq_TH2_Human1.10710704
67* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10472876
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.08387873
69GATA3_27048872_Chip-Seq_THYMUS_Human1.08072449
70* GATA2_21666600_ChIP-Seq_HMVEC_Human1.07776082
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05550653
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03697583
73HTT_18923047_ChIP-ChIP_STHdh_Human1.00598711
74* GATA1_19941827_ChIP-Seq_MEL_Mouse0.99699288
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99445866
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98613113
77PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97286053
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96509297
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96469199
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96176275
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93840566
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92738690
83GATA4_25053715_ChIP-Seq_YYC3_Human0.92686476
84* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91608958
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91473209
86NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91473209
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91001767
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90386835
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90002647
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89800418
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89084746
92* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88513022
93TBX20_22328084_ChIP-Seq_HEART_Mouse0.85914404
94TBX20_22080862_ChIP-Seq_HEART_Mouse0.85914404
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85792791
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85757364
97BCAT_22108803_ChIP-Seq_LS180_Human0.85486035
98TCF7_22412390_ChIP-Seq_EML_Mouse0.84114846
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84085507
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83832203
101* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83803958
102GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83677879
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83602145
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83105575
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82293185
106STAT1_20625510_ChIP-Seq_HELA_Human0.81385616
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80582840
108* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80355264
109SMRT_27268052_Chip-Seq_Bcells_Human0.80290185
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78815400
111GATA2_19941826_ChIP-Seq_K562_Human0.77779535
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77081162
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76644057
114GATA1_19941826_ChIP-Seq_K562_Human0.75886925
115SOX2_20726797_ChIP-Seq_SW620_Human0.74729359
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.74647137
117LXR_22292898_ChIP-Seq_THP-1_Human0.73579439
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72105716
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71978884
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71780025
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.71723552
122CEBPB_22108803_ChIP-Seq_LS180_Human0.71404773
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70716472
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69682852
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68578870
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68065164
127* TP63_23658742_ChIP-Seq_EP156T_Human0.67455544
128AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67263362
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.66989742
130CJUN_26792858_Chip-Seq_BT549_Human0.66703659
131IRF8_27001747_Chip-Seq_BMDM_Mouse0.66609182
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66408586
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.66218486
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.66178785
135SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.65629363
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64484745
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.62538885
138* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.61298610
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60244751
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59077299
141AHR_22903824_ChIP-Seq_MCF-7_Human0.58836381
142EGR1_19032775_ChIP-ChIP_M12_Human0.58429139
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.58177273
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58119356
145VDR_24787735_ChIP-Seq_THP-1_Human0.56383310
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56268103
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55583191
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.54772456
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.54361757
150CBP_21632823_ChIP-Seq_H3396_Human0.54319828
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.53364890
152ERG_21242973_ChIP-ChIP_JURKAT_Human0.53311785
153BRD4_27068464_Chip-Seq_AML-cells_Mouse0.53159284
154* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52952380
155KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.52529195
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52105082
157FOXM1_26456572_ChIP-Seq_MCF-7_Human0.52090353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.95578095
2MP0005360_urolithiasis6.19359372
3MP0005085_abnormal_gallbladder_physiolo5.66402497
4MP0005365_abnormal_bile_salt5.40684842
5MP0003303_peritoneal_inflammation4.60438295
6MP0008875_abnormal_xenobiotic_pharmacok4.51595416
7MP0010329_abnormal_lipoprotein_level3.59150888
8MP0003252_abnormal_bile_duct3.51897528
9MP0003806_abnormal_nucleotide_metabolis3.19717671
10MP0001835_abnormal_antigen_presentation3.03756368
11MP0009785_altered_susceptibility_to3.00696314
12MP0009840_abnormal_foam_cell2.95325413
13MP0002148_abnormal_hypersensitivity_rea2.90158567
14MP0003191_abnormal_cellular_cholesterol2.88847453
15MP0005083_abnormal_biliary_tract2.69381427
16MP0006082_CNS_inflammation2.60490491
17MP0002419_abnormal_innate_immunity2.46185246
18MP0003646_muscle_fatigue2.43460377
19MP0005000_abnormal_immune_tolerance2.37767441
20MP0002332_abnormal_exercise_endurance2.34375681
21MP0004510_myositis2.31091953
22MP0005025_abnormal_response_to2.29075745
23MP0001666_abnormal_nutrient_absorption2.27018721
24MP0001790_abnormal_immune_system2.20549720
25MP0005387_immune_system_phenotype2.20549720
26MP0003950_abnormal_plasma_membrane2.17918908
27MP0005332_abnormal_amino_acid2.17521245
28MP0003195_calcinosis2.15072064
29MP0002118_abnormal_lipid_homeostasis2.12177629
30MP0004019_abnormal_vitamin_homeostasis2.10207674
31MP0003011_delayed_dark_adaptation2.07317727
32MP0000609_abnormal_liver_physiology2.05555859
33MP0001800_abnormal_humoral_immune2.03936838
34MP0002452_abnormal_antigen_presenting2.02355623
35MP0002723_abnormal_immune_serum1.96103802
36MP0002254_reproductive_system_inflammat1.88535559
37MP0005671_abnormal_response_to1.81963910
38MP0001533_abnormal_skeleton_physiology1.81958283
39MP0003828_pulmonary_edema1.77792760
40MP0008004_abnormal_stomach_pH1.75762879
41MP0000685_abnormal_immune_system1.73100929
42MP0003705_abnormal_hypodermis_morpholog1.72434537
43MP0005397_hematopoietic_system_phenotyp1.66634493
44MP0001545_abnormal_hematopoietic_system1.66634493
45MP0005319_abnormal_enzyme/_coenzyme1.66263480
46MP0002420_abnormal_adaptive_immunity1.65823801
47MP0002796_impaired_skin_barrier1.65565803
48MP0001819_abnormal_immune_cell1.65518076
49MP0004130_abnormal_muscle_cell1.63594849
50MP0002138_abnormal_hepatobiliary_system1.62150658
51MP0001845_abnormal_inflammatory_respons1.53573728
52MP0001853_heart_inflammation1.53356692
53MP0010155_abnormal_intestine_physiology1.52347708
54MP0005584_abnormal_enzyme/coenzyme_acti1.51262325
55MP0005670_abnormal_white_adipose1.50275540
56MP0010234_abnormal_vibrissa_follicle1.48912583
57MP0010368_abnormal_lymphatic_system1.47921288
58MP0000343_altered_response_to1.46143993
59MP0002405_respiratory_system_inflammati1.42149049
60MP0000465_gastrointestinal_hemorrhage1.38916681
61MP0003868_abnormal_feces_composition1.36673807
62MP0001764_abnormal_homeostasis1.35891925
63MP0005647_abnormal_sex_gland1.33304370
64MP0009278_abnormal_bone_marrow1.30157549
65MP0005451_abnormal_body_composition1.29515978
66MP0005164_abnormal_response_to1.28724562
67MP0004484_altered_response_of1.27538565
68MP0003448_altered_tumor_morphology1.26979983
69MP0000749_muscle_degeneration1.25721447
70MP0003045_fibrosis1.23073543
71MP0004883_abnormal_blood_vessel1.22395045
72MP0005310_abnormal_salivary_gland1.21381893
73MP0002998_abnormal_bone_remodeling1.20750545
74MP0006054_spinal_hemorrhage1.20715980
75MP0000716_abnormal_immune_system1.16520681
76MP0009697_abnormal_copulation1.15833431
77MP0008260_abnormal_autophagy1.15416197
78MP0005666_abnormal_adipose_tissue1.14541990
79MP0000858_altered_metastatic_potential1.13294131
80MP0005167_abnormal_blood-brain_barrier1.12825267
81MP0009643_abnormal_urine_homeostasis1.10254135
82MP0009764_decreased_sensitivity_to1.10045353
83MP0002971_abnormal_brown_adipose1.09090468
84MP0003763_abnormal_thymus_physiology1.07830758
85MP0000604_amyloidosis1.04935339
86MP0003172_abnormal_lysosome_physiology1.04622608
87MP0002398_abnormal_bone_marrow1.04285971
88MP0000598_abnormal_liver_morphology1.02939461
89MP0002006_tumorigenesis1.01722918
90MP0010352_gastrointestinal_tract_polyps1.00707066
91MP0003221_abnormal_cardiomyocyte_apopto1.00310808
92MP0009763_increased_sensitivity_to1.00131127
93MP0003091_abnormal_cell_migration0.98801059
94MP0002837_dystrophic_cardiac_calcinosis0.96932103
95MP0003656_abnormal_erythrocyte_physiolo0.95206213
96MP0004036_abnormal_muscle_relaxation0.95022931
97MP0004381_abnormal_hair_follicle0.94277125
98MP0005334_abnormal_fat_pad0.92532918
99MP0005023_abnormal_wound_healing0.92319967
100MP0004185_abnormal_adipocyte_glucose0.92190021
101MP0003724_increased_susceptibility_to0.92058281
102MP0003690_abnormal_glial_cell0.91943387
103MP0003186_abnormal_redox_activity0.91449631
104MP0009333_abnormal_splenocyte_physiolog0.89480016
105MP0004782_abnormal_surfactant_physiolog0.88776333
106MP0000689_abnormal_spleen_morphology0.88745519
107MP0005165_increased_susceptibility_to0.88655234
108MP0008469_abnormal_protein_level0.86984867
109MP0002060_abnormal_skin_morphology0.85390045
110MP0000569_abnormal_digit_pigmentation0.84950582
111MP0002429_abnormal_blood_cell0.84924687
112MP0000579_abnormal_nail_morphology0.84140731
113MP0004233_abnormal_muscle_weight0.82324314
114MP0002722_abnormal_immune_system0.80529229
115MP0009642_abnormal_blood_homeostasis0.78005272
116MP0002277_abnormal_respiratory_mucosa0.77520996
117MP0005084_abnormal_gallbladder_morpholo0.76140892
118MP0005464_abnormal_platelet_physiology0.74052595
119MP0003436_decreased_susceptibility_to0.73902493
120MP0002078_abnormal_glucose_homeostasis0.73830741
121MP0005535_abnormal_body_temperature0.73569267
122MP0002972_abnormal_cardiac_muscle0.72367129
123MP0005636_abnormal_mineral_homeostasis0.72149281
124MP0005275_abnormal_skin_tensile0.71745955
125MP0003075_altered_response_to0.71639731
126MP0000750_abnormal_muscle_regeneration0.69891849
127MP0003453_abnormal_keratinocyte_physiol0.69599422
128MP0005376_homeostasis/metabolism_phenot0.69535873
129MP0005058_abnormal_lysosome_morphology0.68854683
130MP0000015_abnormal_ear_pigmentation0.67844577
131MP0001879_abnormal_lymphatic_vessel0.67000064
132MP0004084_abnormal_cardiac_muscle0.66612294
133MP0004808_abnormal_hematopoietic_stem0.66503224
134MP0004947_skin_inflammation0.65965428
135MP0005501_abnormal_skin_physiology0.65855067
136MP0006036_abnormal_mitochondrial_physio0.65529499
137MP0000427_abnormal_hair_cycle0.65352887
138MP0000371_diluted_coat_color0.65256265
139MP0005390_skeleton_phenotype0.63985385
140MP0000372_irregular_coat_pigmentation0.63308862
141MP0001216_abnormal_epidermal_layer0.62088629
142MP0005166_decreased_susceptibility_to0.61763129
143MP0003638_abnormal_response/metabolism_0.61756296
144MP0009115_abnormal_fat_cell0.61352953
145MP0005408_hypopigmentation0.60602192
146MP0001881_abnormal_mammary_gland0.60566264
147MP0009765_abnormal_xenobiotic_induced0.60011688
148MP0003300_gastrointestinal_ulcer0.59194982
149MP0001756_abnormal_urination0.59033441
150MP0009384_cardiac_valve_regurgitation0.58975551
151MP0003566_abnormal_cell_adhesion0.57525050
152MP0005375_adipose_tissue_phenotype0.57196511
153MP0002090_abnormal_vision0.57136883
154MP0000249_abnormal_blood_vessel0.56838587
155MP0002098_abnormal_vibrissa_morphology0.55837769
156MP0005448_abnormal_energy_balance0.55330101
157MP0000647_abnormal_sebaceous_gland0.55205698
158MP0002928_abnormal_bile_duct0.55169811
159MP0001661_extended_life_span0.53951258
160MP0008874_decreased_physiological_sensi0.53793181
161MP0002166_altered_tumor_susceptibility0.52836641
162MP0005410_abnormal_fertilization0.50122867
163MP0002876_abnormal_thyroid_physiology0.49733717
164MP0002136_abnormal_kidney_physiology0.48679095
165MP0005266_abnormal_metabolism0.46840532
166MP0006138_congestive_heart_failure0.46618153
167MP0000377_abnormal_hair_follicle0.46617699
168MP0000230_abnormal_systemic_arterial0.46353363
169MP0004147_increased_porphyrin_level0.45407201
170MP0001851_eye_inflammation0.44658055

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.87144801
2Intrahepatic cholestasis (HP:0001406)6.34593865
3Complement deficiency (HP:0004431)6.13946611
4Xanthomatosis (HP:0000991)5.72675731
5Prolonged partial thromboplastin time (HP:0003645)5.68578747
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.53057268
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.39913038
8Hypobetalipoproteinemia (HP:0003563)5.26068018
9Hyperlipoproteinemia (HP:0010980)4.93693645
10Recurrent bacterial skin infections (HP:0005406)4.81110065
11Retrobulbar optic neuritis (HP:0100654)4.74485057
12Optic neuritis (HP:0100653)4.74485057
13Orchitis (HP:0100796)4.68307404
14Abnormality of complement system (HP:0005339)4.58090340
15Nemaline bodies (HP:0003798)4.57499875
16Joint hemorrhage (HP:0005261)4.47053847
17Muscle fiber inclusion bodies (HP:0100299)4.41229122
18Myositis (HP:0100614)4.37944481
19Hypolipoproteinemia (HP:0010981)4.36443386
20Eczematoid dermatitis (HP:0000976)4.36358106
21Epidermoid cyst (HP:0200040)4.35312268
22Recurrent abscess formation (HP:0002722)4.30790586
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.29630024
24Abnormality of the common coagulation pathway (HP:0010990)4.23980602
25Hypoalphalipoproteinemia (HP:0003233)4.17338288
26Stomatitis (HP:0010280)4.08937760
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.06787734
28Hyperammonemia (HP:0001987)4.01162385
29Abnormality of macrophages (HP:0004311)3.97806374
30Ketosis (HP:0001946)3.81152267
31Hypoglycemic coma (HP:0001325)3.77040908
32Hyperglycinemia (HP:0002154)3.71228408
33Abnormality of glycolipid metabolism (HP:0010969)3.68296641
34Abnormality of liposaccharide metabolism (HP:0010968)3.68296641
35Abnormality of glycosphingolipid metabolism (HP:0004343)3.68296641
36Keratoconjunctivitis sicca (HP:0001097)3.66613068
37Systemic lupus erythematosus (HP:0002725)3.66010147
38Hypercholesterolemia (HP:0003124)3.61027626
39Fat malabsorption (HP:0002630)3.57473473
40Hyperglycinuria (HP:0003108)3.48602273
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.47409368
42Abnormality of the intrinsic pathway (HP:0010989)3.45031634
43Keratoconjunctivitis (HP:0001096)3.40442880
44Abnormality of glycine metabolism (HP:0010895)3.35778815
45Abnormality of serine family amino acid metabolism (HP:0010894)3.35778815
46Abnormality of sulfur amino acid metabolism (HP:0004339)3.28380102
47Elevated erythrocyte sedimentation rate (HP:0003565)3.27416265
48Myocardial infarction (HP:0001658)3.21476229
49Mediastinal lymphadenopathy (HP:0100721)3.14986800
50Muscle fiber splitting (HP:0003555)3.14796133
51Abnormality of methionine metabolism (HP:0010901)3.13748461
52Abnormality of aspartate family amino acid metabolism (HP:0010899)3.11366754
53Abnormality of fatty-acid metabolism (HP:0004359)3.00234758
54Glomerulonephritis (HP:0000099)2.97803760
55Recurrent gram-negative bacterial infections (HP:0005420)2.95998524
56Recurrent skin infections (HP:0001581)2.94014939
57Hematochezia (HP:0002573)2.93792744
58Gangrene (HP:0100758)2.92391579
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.88070239
60Esophageal varix (HP:0002040)2.87730312
61Abnormal gallbladder physiology (HP:0012438)2.87291300
62Cholecystitis (HP:0001082)2.87291300
63Conjugated hyperbilirubinemia (HP:0002908)2.86139846
64Spontaneous abortion (HP:0005268)2.85509169
65Spontaneous hematomas (HP:0007420)2.83422671
66Ketoacidosis (HP:0001993)2.78266723
67Thick nail (HP:0001805)2.75836396
68Hepatocellular carcinoma (HP:0001402)2.74233305
69Hemoptysis (HP:0002105)2.74047809
70Asymmetric septal hypertrophy (HP:0001670)2.73431588
71Vasculitis (HP:0002633)2.70698305
72Skin nodule (HP:0200036)2.69869695
73Steatorrhea (HP:0002570)2.68691432
74Gastrointestinal infarctions (HP:0005244)2.68597479
75Hyperbilirubinemia (HP:0002904)2.67166113
76Arterial thrombosis (HP:0004420)2.66407544
77Increased IgE level (HP:0003212)2.65686693
78Amyloidosis (HP:0011034)2.65444796
79Cholelithiasis (HP:0001081)2.65422599
80Vascular calcification (HP:0004934)2.63143293
81Recurrent fungal infections (HP:0002841)2.62617469
82Pulmonary infiltrates (HP:0002113)2.60440748
83Abnormal gallbladder morphology (HP:0012437)2.58012258
84Abnormality of purine metabolism (HP:0004352)2.54932447
85Increased cerebral lipofuscin (HP:0011813)2.54602257
86Exercise-induced muscle cramps (HP:0003710)2.53842532
87Abnormality of nucleobase metabolism (HP:0010932)2.53689038
88Distal lower limb muscle weakness (HP:0009053)2.51621173
89Abnormality of pyrimidine metabolism (HP:0004353)2.51202220
90Increased serum ferritin (HP:0003281)2.46847999
91Type 1 muscle fiber predominance (HP:0003803)2.45956737
92Loss of speech (HP:0002371)2.45827032
93Hemorrhage of the eye (HP:0011885)2.44829991
94Disinhibition (HP:0000734)2.44538629
95Delayed CNS myelination (HP:0002188)2.42525312
96Hypoglycemic seizures (HP:0002173)2.38800375
97Nephritis (HP:0000123)2.37491314
98Gingivitis (HP:0000230)2.37392694
99Muscle hypertrophy of the lower extremities (HP:0008968)2.35519708
100Chest pain (HP:0100749)2.34985613
101Cardiovascular calcification (HP:0011915)2.33672199
102Autoimmune thrombocytopenia (HP:0001973)2.32055439
103Meningitis (HP:0001287)2.30931574
104T lymphocytopenia (HP:0005403)2.28875485
105Autoimmune hemolytic anemia (HP:0001890)2.28612935
106Urticaria (HP:0001025)2.27673335
107Metabolic acidosis (HP:0001942)2.27326978
108Frequent falls (HP:0002359)2.26402074
109Abnormality of serum amino acid levels (HP:0003112)2.24893507
110Mitral stenosis (HP:0001718)2.24870508
111Polyneuropathy (HP:0001271)2.24848737
112Abnormality of T cell number (HP:0011839)2.23394860
113Chronic obstructive pulmonary disease (HP:0006510)2.23348328
114Obstructive lung disease (HP:0006536)2.23348328
115Right ventricular cardiomyopathy (HP:0011663)2.23018995
116Recurrent viral infections (HP:0004429)2.21592030
117Interstitial pulmonary disease (HP:0006530)2.21474883
118Hypochromic microcytic anemia (HP:0004840)2.21403761
119Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21080335
120Dicarboxylic aciduria (HP:0003215)2.21080335
121Acanthocytosis (HP:0001927)2.20790575
122Vacuolated lymphocytes (HP:0001922)2.20419734
123EMG: myopathic abnormalities (HP:0003458)2.19590386
124Gout (HP:0001997)2.18470855
125Spastic diplegia (HP:0001264)2.18352880
126Neonatal onset (HP:0003623)2.17409723
127Malnutrition (HP:0004395)2.17305024
128Menorrhagia (HP:0000132)2.16779539
129Encephalitis (HP:0002383)2.16652178
130Episodic fever (HP:0001954)2.16647805
131Difficulty running (HP:0009046)2.14971857
132Calf muscle hypertrophy (HP:0008981)2.11851983
133Pigmentary retinal degeneration (HP:0001146)2.11424680
134Recurrent cutaneous fungal infections (HP:0011370)2.10143651
135Chronic mucocutaneous candidiasis (HP:0002728)2.10143651
136Gingival bleeding (HP:0000225)2.10137154
137Dysostosis multiplex (HP:0000943)2.10015632
138Prolonged bleeding time (HP:0003010)2.09745733
139Anorexia (HP:0002039)2.07656556
140Vertigo (HP:0002321)2.07375723
141Malignant hyperthermia (HP:0002047)2.06646570
142Sensorimotor neuropathy (HP:0007141)2.05665955
143Abnormality of the gallbladder (HP:0005264)2.04258728
144Leukocytosis (HP:0001974)2.03201128
145Neck muscle weakness (HP:0000467)2.02971594
146Increased neuronal autofluorescent lipopigment (HP:0002074)2.02417838
147Lethargy (HP:0001254)2.01999575
148Thrombophlebitis (HP:0004418)2.01872233
149Petechiae (HP:0000967)1.98522910
150Upper motor neuron abnormality (HP:0002127)1.97706064
151Polycythemia (HP:0001901)1.96876231
152Hypertriglyceridemia (HP:0002155)1.96117693
153Stroke (HP:0001297)1.95860047
154Basal ganglia calcification (HP:0002135)1.95671404
155Hyperinsulinemic hypoglycemia (HP:0000825)1.95537438
156Pancreatitis (HP:0001733)1.94205193
157Abnormal delayed hypersensitivity skin test (HP:0002963)1.92183541
158Distal arthrogryposis (HP:0005684)1.91886647
159Myoglobinuria (HP:0002913)1.91775641
160Parakeratosis (HP:0001036)1.91653059
161Epistaxis (HP:0000421)1.91353743
162Abnormality of the endocardium (HP:0004306)1.89689310
163Abnormality of the pleura (HP:0002103)1.88119418
164Late onset (HP:0003584)1.86747117
165Abnormality of proline metabolism (HP:0010907)1.86482439
166Hydroxyprolinuria (HP:0003080)1.86482439
167Hyporeflexia of lower limbs (HP:0002600)1.85934672
168Keratitis (HP:0000491)1.84195367
169Abnormality of iron homeostasis (HP:0011031)1.83912083
170Hypergammaglobulinemia (HP:0010702)1.82960316
171Abnormality of the left ventricular outflow tract (HP:0011103)1.82780368
172Subaortic stenosis (HP:0001682)1.82780368
173Irritability (HP:0000737)1.80741570
174Bulbar palsy (HP:0001283)1.79529306
175Abnormality of transition element cation homeostasis (HP:0011030)1.78375917
176Osteomyelitis (HP:0002754)1.78193337
177Exercise-induced myalgia (HP:0003738)1.77791262
178Popliteal pterygium (HP:0009756)1.76718627
179Fatigable weakness (HP:0003473)1.76655456
180Abnormality of the neuromuscular junction (HP:0003398)1.76655456
181Abnormality of the Achilles tendon (HP:0005109)1.76348124
182Centrally nucleated skeletal muscle fibers (HP:0003687)1.74722665
183Axonal loss (HP:0003447)1.72844889
184Vomiting (HP:0002013)1.71669594
185Cerebral edema (HP:0002181)1.71158365
186Poikilocytosis (HP:0004447)1.68375420
187Pulmonary embolism (HP:0002204)1.66919265
188Acanthosis nigricans (HP:0000956)1.64016319
189Brushfield spots (HP:0001088)1.63320158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.93762838
2ERN13.56532145
3SIK13.25161095
4BLK2.88670471
5RIPK42.75337884
6FGFR42.69519390
7MST1R2.60877127
8IRAK42.54668728
9TRIB32.44947923
10BMPR22.34345909
11TGFBR22.23990248
12TAOK32.23223519
13TIE12.21574009
14INSRR2.11178517
15IKBKB2.08644953
16PDK42.07023884
17PDK32.07023884
18RIPK12.00688674
19JAK31.91704944
20FGR1.91303627
21PKN21.88944316
22GRK71.87879207
23MAP3K131.86035857
24MATK1.84494135
25PTK61.81634667
26MAP4K11.76797314
27PIK3CG1.76474825
28CAMK1D1.74752201
29PDK21.74736435
30MAP2K41.71040966
31ERBB41.61685186
32DAPK21.59655933
33TYK21.50828502
34TTN1.49770492
35FRK1.49024499
36MAP3K31.49003877
37NEK91.48792324
38IRAK11.47272601
39LATS11.46925563
40ZAP701.45144398
41MAP2K31.35321396
42MOS1.34388547
43TXK1.34224231
44FES1.33096570
45MAPK111.33021020
46TAOK21.31251278
47PRKAA21.31226813
48MAP3K141.28440547
49CAMK1G1.28052337
50KDR1.26528591
51JAK11.21673520
52MAPKAPK31.21364122
53MYLK1.15003778
54DDR21.14007815
55SYK1.11910259
56TAOK11.11273513
57GRK11.08385880
58FGFR21.08299404
59MAPK121.07901914
60JAK21.07473350
61MAP3K71.07272166
62CHUK1.06750193
63BTK1.05869388
64IRAK21.05329803
65STK101.01251784
66LYN1.00541917
67HCK1.00183909
68MST40.98647136
69FER0.98540757
70PRPF4B0.98228733
71TBK10.98175225
72TEC0.97915366
73CDK60.97450002
74FGFR30.96318491
75MAPK150.95576587
76MARK30.93574250
77KIT0.92335162
78EPHB10.92135214
79OBSCN0.91918287
80STK380.88897409
81SGK30.87953432
82FLT30.86738691
83MAP3K120.85864997
84SIK30.85405867
85EIF2AK30.83693617
86IRAK30.79322991
87TNK20.78899080
88ACVR1B0.75656973
89PTK2B0.74847619
90LCK0.74729815
91GSK3A0.73258922
92PDPK10.71338489
93MAPK40.70222848
94CSK0.69995613
95PIK3CA0.69059574
96ICK0.69021138
97CDC42BPA0.68682654
98ERBB20.67903001
99MET0.66207963
100MAP2K60.65982484
101SGK20.65359693
102PRKAA10.65182895
103CSF1R0.64740647
104PINK10.63929944
105DYRK1B0.62935481
106MAP3K20.62823103
107PDK10.62062833
108PHKG20.61364151
109PHKG10.61364151
110PRKACG0.59727717
111ABL20.58621119
112MAP3K60.58025658
113PIM10.57366033
114MAP2K10.56365605
115ITK0.55721346
116ABL10.55471527
117STK38L0.55422852
118LRRK20.54897128
119STK30.54695157
120TRPM70.54579925
121BMX0.54473190
122MUSK0.54207019
123PRKCZ0.53287391
124NME20.52899005
125AKT30.52620250
126GRK60.51719618
127IKBKE0.51461815
128STK240.50287961
129EPHA30.49508136
130IGF1R0.48346304
131PIM20.47753840
132NLK0.47738269
133RET0.47086366
134PTK20.46247106
135EPHB20.46234586
136EGFR0.46094801
137CAMKK10.46054398
138MAPK70.44830791
139LMTK20.43470505
140PRKD10.42491675
141CAMK2G0.41891105
142PRKCH0.41463678
143MAP3K10.40984630
144ADRBK20.40945455
145MAP3K50.34914079
146EEF2K0.33018235
147MAP3K110.32171505
148SGK2230.32115690
149MARK20.30148266
150OXSR10.28070521
151MAPKAPK20.26996749
152KSR20.26982726

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.29799882
2Nitrogen metabolism_Homo sapiens_hsa009104.00894110
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.42106208
4Arginine biosynthesis_Homo sapiens_hsa002203.02096729
5Complement and coagulation cascades_Homo sapiens_hsa046102.98013276
6Leishmaniasis_Homo sapiens_hsa051402.90567917
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.87400501
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73116033
9Osteoclast differentiation_Homo sapiens_hsa043802.72257323
10Fatty acid degradation_Homo sapiens_hsa000712.61028090
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.56694444
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45688952
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44350904
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.43877809
15Legionellosis_Homo sapiens_hsa051342.41996726
16Tryptophan metabolism_Homo sapiens_hsa003802.40840230
17Allograft rejection_Homo sapiens_hsa053302.39118930
18Graft-versus-host disease_Homo sapiens_hsa053322.33362838
19Tuberculosis_Homo sapiens_hsa051522.28335549
20Malaria_Homo sapiens_hsa051442.28111847
21NF-kappa B signaling pathway_Homo sapiens_hsa040642.25555520
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24310078
23Staphylococcus aureus infection_Homo sapiens_hsa051502.23828676
24PPAR signaling pathway_Homo sapiens_hsa033202.21045367
25Rheumatoid arthritis_Homo sapiens_hsa053232.13650604
26Asthma_Homo sapiens_hsa053102.13419773
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.11651702
28Propanoate metabolism_Homo sapiens_hsa006402.10490384
29TNF signaling pathway_Homo sapiens_hsa046682.04133647
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03371771
31Fatty acid metabolism_Homo sapiens_hsa012121.98357226
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97717573
33Caffeine metabolism_Homo sapiens_hsa002321.97445929
34Autoimmune thyroid disease_Homo sapiens_hsa053201.96919610
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95911100
36Peroxisome_Homo sapiens_hsa041461.93285113
37Butanoate metabolism_Homo sapiens_hsa006501.87857922
38Influenza A_Homo sapiens_hsa051641.87617667
39Chemical carcinogenesis_Homo sapiens_hsa052041.81913574
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80052787
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.75609823
42Histidine metabolism_Homo sapiens_hsa003401.70995882
43Type I diabetes mellitus_Homo sapiens_hsa049401.69386558
44Toxoplasmosis_Homo sapiens_hsa051451.69334300
45Measles_Homo sapiens_hsa051621.67783293
46beta-Alanine metabolism_Homo sapiens_hsa004101.67114067
47Retinol metabolism_Homo sapiens_hsa008301.63445435
48Hematopoietic cell lineage_Homo sapiens_hsa046401.62098810
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.61161239
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59351452
51B cell receptor signaling pathway_Homo sapiens_hsa046621.59055087
52Bile secretion_Homo sapiens_hsa049761.57571520
53Phenylalanine metabolism_Homo sapiens_hsa003601.57385373
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54813397
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53131271
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52822268
57Viral myocarditis_Homo sapiens_hsa054161.43054785
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.42620923
59Pyruvate metabolism_Homo sapiens_hsa006201.41350865
60Salmonella infection_Homo sapiens_hsa051321.40521974
61ABC transporters_Homo sapiens_hsa020101.38849134
62Tyrosine metabolism_Homo sapiens_hsa003501.35374783
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33350215
64Herpes simplex infection_Homo sapiens_hsa051681.32677853
65Starch and sucrose metabolism_Homo sapiens_hsa005001.30280974
66Fatty acid elongation_Homo sapiens_hsa000621.28310062
67Drug metabolism - other enzymes_Homo sapiens_hsa009831.27575320
68Selenocompound metabolism_Homo sapiens_hsa004501.26536049
69Chemokine signaling pathway_Homo sapiens_hsa040621.24316319
70Fat digestion and absorption_Homo sapiens_hsa049751.23398420
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22171258
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21324631
73Antigen processing and presentation_Homo sapiens_hsa046121.18445081
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17239374
75Carbon metabolism_Homo sapiens_hsa012001.16911797
76Phagosome_Homo sapiens_hsa041451.15519936
77Fatty acid biosynthesis_Homo sapiens_hsa000611.12763119
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11089855
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08199188
80Sulfur metabolism_Homo sapiens_hsa009201.07441008
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05160851
82Hepatitis B_Homo sapiens_hsa051611.04197865
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03972582
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03054992
85Acute myeloid leukemia_Homo sapiens_hsa052211.02776820
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02578930
87Biosynthesis of amino acids_Homo sapiens_hsa012300.99804108
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.97739362
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94242048
90Shigellosis_Homo sapiens_hsa051310.92205696
91T cell receptor signaling pathway_Homo sapiens_hsa046600.90236325
92Platelet activation_Homo sapiens_hsa046110.88434909
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.86934298
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86276923
95Glycerolipid metabolism_Homo sapiens_hsa005610.83061915
96Vitamin digestion and absorption_Homo sapiens_hsa049770.79634761
97Bladder cancer_Homo sapiens_hsa052190.79463058
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79130552
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79102944
100Apoptosis_Homo sapiens_hsa042100.78180447
101Primary immunodeficiency_Homo sapiens_hsa053400.78110976
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77074661
103Vitamin B6 metabolism_Homo sapiens_hsa007500.71704416
104Lysine degradation_Homo sapiens_hsa003100.70684238
105Prolactin signaling pathway_Homo sapiens_hsa049170.69312341
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.65462360
107FoxO signaling pathway_Homo sapiens_hsa040680.65357077
108Steroid biosynthesis_Homo sapiens_hsa001000.62401402
109HIF-1 signaling pathway_Homo sapiens_hsa040660.61909151
110Pentose phosphate pathway_Homo sapiens_hsa000300.61273116
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59885724
112Arginine and proline metabolism_Homo sapiens_hsa003300.59806544
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.59733134
114Sphingolipid metabolism_Homo sapiens_hsa006000.58876096
115VEGF signaling pathway_Homo sapiens_hsa043700.58495435
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58404305
117Folate biosynthesis_Homo sapiens_hsa007900.58010642
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.57004071
119Insulin resistance_Homo sapiens_hsa049310.56156243
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56127094
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55687256
122Sulfur relay system_Homo sapiens_hsa041220.55141444
123Pancreatic cancer_Homo sapiens_hsa052120.52873723
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52846411
125Epstein-Barr virus infection_Homo sapiens_hsa051690.51238631
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50809384
127Glutathione metabolism_Homo sapiens_hsa004800.49635424
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.49482263
129Circadian rhythm_Homo sapiens_hsa047100.46530843
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.45884428
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44530461
132Renal cell carcinoma_Homo sapiens_hsa052110.43288740
133Chronic myeloid leukemia_Homo sapiens_hsa052200.43144887
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.40715523
135Non-small cell lung cancer_Homo sapiens_hsa052230.39767180
136Glucagon signaling pathway_Homo sapiens_hsa049220.39602748
137Prion diseases_Homo sapiens_hsa050200.39075897
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38439800
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37410005
140Endocytosis_Homo sapiens_hsa041440.34246638
141Prostate cancer_Homo sapiens_hsa052150.33836364
142Proteoglycans in cancer_Homo sapiens_hsa052050.32599829
143Galactose metabolism_Homo sapiens_hsa000520.31370862
144Fructose and mannose metabolism_Homo sapiens_hsa000510.30937740
145MAPK signaling pathway_Homo sapiens_hsa040100.29968692
146Mineral absorption_Homo sapiens_hsa049780.29512775
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29377888
148Small cell lung cancer_Homo sapiens_hsa052220.29354942
149Metabolic pathways_Homo sapiens_hsa011000.29309162
150GnRH signaling pathway_Homo sapiens_hsa049120.28948751
151Linoleic acid metabolism_Homo sapiens_hsa005910.27934785
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.27242173
153HTLV-I infection_Homo sapiens_hsa051660.26135304
154Viral carcinogenesis_Homo sapiens_hsa052030.24860627
155AMPK signaling pathway_Homo sapiens_hsa041520.24737712
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.22380339
157Systemic lupus erythematosus_Homo sapiens_hsa053220.22220356
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22113860
159Insulin signaling pathway_Homo sapiens_hsa049100.12013831
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10820309
161Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07778374
162Ovarian steroidogenesis_Homo sapiens_hsa049130.07679568
163Lysosome_Homo sapiens_hsa041420.06316099
164Amoebiasis_Homo sapiens_hsa051460.05976658
165Central carbon metabolism in cancer_Homo sapiens_hsa052300.01173362
166African trypanosomiasis_Homo sapiens_hsa05143-0.1155560
167Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1060653
168Adherens junction_Homo sapiens_hsa04520-0.0954304
169Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0900105
170Type II diabetes mellitus_Homo sapiens_hsa04930-0.0892724
171Other glycan degradation_Homo sapiens_hsa00511-0.0860772
172Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0819149
173Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0732080
174One carbon pool by folate_Homo sapiens_hsa00670-0.0694757
175Hepatitis C_Homo sapiens_hsa05160-0.0678057
176Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0648885
177Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0502239
178Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0493418
179Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0110932
180Pertussis_Homo sapiens_hsa05133-0.0078703

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