RNF128

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.55158073
2L-phenylalanine catabolic process (GO:0006559)5.55158073
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.53342361
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.39608431
5L-phenylalanine metabolic process (GO:0006558)5.39608431
6epoxygenase P450 pathway (GO:0019373)5.30006173
7aromatic amino acid family catabolic process (GO:0009074)4.88814623
8cysteine metabolic process (GO:0006534)4.77420411
9sulfur amino acid catabolic process (GO:0000098)4.61697108
10exogenous drug catabolic process (GO:0042738)4.54432126
11urea metabolic process (GO:0019627)4.50821253
12urea cycle (GO:0000050)4.50821253
13high-density lipoprotein particle remodeling (GO:0034375)4.39957615
14kynurenine metabolic process (GO:0070189)4.37983287
15glyoxylate metabolic process (GO:0046487)4.37575798
16low-density lipoprotein particle remodeling (GO:0034374)4.30611515
17indole-containing compound catabolic process (GO:0042436)4.29701881
18indolalkylamine catabolic process (GO:0046218)4.29701881
19tryptophan catabolic process (GO:0006569)4.29701881
20blood coagulation, intrinsic pathway (GO:0007597)4.28955385
21peptidyl-glutamic acid carboxylation (GO:0017187)4.25813900
22protein carboxylation (GO:0018214)4.25813900
23lysine metabolic process (GO:0006553)4.24925992
24lysine catabolic process (GO:0006554)4.24925992
25bile acid biosynthetic process (GO:0006699)4.24044697
26alpha-linolenic acid metabolic process (GO:0036109)4.21435252
27negative regulation of protein activation cascade (GO:2000258)4.21300635
28regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.17119382
29tryptophan metabolic process (GO:0006568)4.17035391
30reverse cholesterol transport (GO:0043691)4.15611697
31homocysteine metabolic process (GO:0050667)4.14083353
32nitrogen cycle metabolic process (GO:0071941)4.11586179
33intestinal cholesterol absorption (GO:0030299)4.09649553
34plasma lipoprotein particle remodeling (GO:0034369)4.09181136
35protein-lipid complex remodeling (GO:0034368)4.09181136
36macromolecular complex remodeling (GO:0034367)4.09181136
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.09060215
38regulation of triglyceride catabolic process (GO:0010896)4.08713585
39plasma lipoprotein particle clearance (GO:0034381)4.06744651
40drug metabolic process (GO:0017144)4.01935576
41complement activation, alternative pathway (GO:0006957)3.99016547
42bile acid metabolic process (GO:0008206)3.89637210
43negative regulation of blood coagulation (GO:0030195)3.88903777
44negative regulation of hemostasis (GO:1900047)3.88903777
45amino-acid betaine metabolic process (GO:0006577)3.86071342
46regulation of cholesterol esterification (GO:0010872)3.83037126
47cholesterol efflux (GO:0033344)3.82932254
48regulation of protein activation cascade (GO:2000257)3.82898798
49drug catabolic process (GO:0042737)3.82021215
50phospholipid efflux (GO:0033700)3.81203779
51phenylpropanoid metabolic process (GO:0009698)3.80849522
52cellular glucuronidation (GO:0052695)3.80841766
53bile acid and bile salt transport (GO:0015721)3.80477053
54negative regulation of coagulation (GO:0050819)3.78201071
55triglyceride homeostasis (GO:0070328)3.76262179
56acylglycerol homeostasis (GO:0055090)3.76262179
57positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.75141933
58flavonoid metabolic process (GO:0009812)3.73468825
59negative regulation of fibrinolysis (GO:0051918)3.73327640
60negative regulation of cholesterol transport (GO:0032375)3.72775025
61negative regulation of sterol transport (GO:0032372)3.72775025
62regulation of plasminogen activation (GO:0010755)3.71276015
63aromatic amino acid family metabolic process (GO:0009072)3.70241157
64omega-hydroxylase P450 pathway (GO:0097267)3.69913155
65drug transmembrane transport (GO:0006855)3.68904650
66intestinal absorption (GO:0050892)3.68550222
67cellular ketone body metabolic process (GO:0046950)3.68399486
68aldehyde catabolic process (GO:0046185)3.67351557
69negative regulation of lipase activity (GO:0060192)3.66572746
70daunorubicin metabolic process (GO:0044597)3.65391623
71polyketide metabolic process (GO:0030638)3.65391623
72doxorubicin metabolic process (GO:0044598)3.65391623
73glucuronate metabolic process (GO:0019585)3.64700688
74uronic acid metabolic process (GO:0006063)3.64700688
75negative regulation of wound healing (GO:0061045)3.61051655
76regulation of complement activation (GO:0030449)3.61013244
77serine family amino acid catabolic process (GO:0009071)3.59050767
78regulation of fibrinolysis (GO:0051917)3.58019165
79phospholipid homeostasis (GO:0055091)3.54394227
80cellular modified amino acid catabolic process (GO:0042219)3.53976319
81plasma lipoprotein particle assembly (GO:0034377)3.53140571
82lipoprotein metabolic process (GO:0042157)3.51352978
83fat-soluble vitamin biosynthetic process (GO:0042362)3.48203214
84tyrosine metabolic process (GO:0006570)3.46149482
85negative regulation of complement activation (GO:0045916)3.41999505
86ethanol metabolic process (GO:0006067)3.41489241
87regulation of cholesterol homeostasis (GO:2000188)3.41088926
88protein activation cascade (GO:0072376)3.40515120
89acute-phase response (GO:0006953)3.38775453
90alpha-amino acid catabolic process (GO:1901606)3.38529756
91short-chain fatty acid metabolic process (GO:0046459)3.37810238
92glutamate metabolic process (GO:0006536)3.37552688
93sterol homeostasis (GO:0055092)3.35019956
94cholesterol homeostasis (GO:0042632)3.34898247
95indolalkylamine metabolic process (GO:0006586)3.33550791
96lipoprotein transport (GO:0042953)3.33406725
97benzene-containing compound metabolic process (GO:0042537)3.31328481
98very-low-density lipoprotein particle assembly (GO:0034379)3.31010435
99positive regulation of lipoprotein lipase activity (GO:0051006)3.30799555
100positive regulation of triglyceride lipase activity (GO:0061365)3.30799555
101positive regulation of lipid catabolic process (GO:0050996)3.29143686
102cellular amino acid catabolic process (GO:0009063)3.29124271
103plasma lipoprotein particle organization (GO:0071827)3.29036275
104protein-lipid complex assembly (GO:0065005)3.27873305
105aminoglycoside antibiotic metabolic process (GO:0030647)3.26941922
106hormone catabolic process (GO:0042447)3.26487720
1072-oxoglutarate metabolic process (GO:0006103)3.23737632
108complement activation, classical pathway (GO:0006958)3.22807958
109regulation of bile acid biosynthetic process (GO:0070857)3.21606643
110ethanol oxidation (GO:0006069)3.20254662
111angiotensin maturation (GO:0002003)3.18873523
112positive regulation of steroid metabolic process (GO:0045940)3.18355951
113fatty acid oxidation (GO:0019395)3.16867240
114fibrinolysis (GO:0042730)3.16039035
115protein-lipid complex subunit organization (GO:0071825)3.15920075
116cholesterol transport (GO:0030301)3.14092194
117sterol transport (GO:0015918)3.14092194
118ketone body metabolic process (GO:1902224)3.13993065
119fatty acid beta-oxidation (GO:0006635)3.13857772
120low-density lipoprotein particle clearance (GO:0034383)3.13074067
121lipid oxidation (GO:0034440)3.12721214
122L-ascorbic acid metabolic process (GO:0019852)3.12706021
123regulation of humoral immune response (GO:0002920)3.12596062
124alkaloid metabolic process (GO:0009820)3.12332932
125drug transport (GO:0015893)3.11192934
126urate metabolic process (GO:0046415)3.08637479
127xenobiotic catabolic process (GO:0042178)3.06267714
128response to nitrosative stress (GO:0051409)3.04524118
129lipid homeostasis (GO:0055088)3.02729753
130organic acid catabolic process (GO:0016054)3.02605482
131carboxylic acid catabolic process (GO:0046395)3.02605482
132heme transport (GO:0015886)3.02319058
133monocarboxylic acid catabolic process (GO:0072329)3.01155295
134aspartate family amino acid catabolic process (GO:0009068)3.00750083
135diacylglycerol metabolic process (GO:0046339)2.99664705
136regulation of apoptotic cell clearance (GO:2000425)2.98874947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.72010573
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.35756561
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.57403446
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.25405845
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.68800589
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.14684770
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.03144938
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.45264933
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.07619561
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.53851878
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20169622
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.19459904
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16912290
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.13427727
15GATA1_22025678_ChIP-Seq_K562_Human2.06360375
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.98222585
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96307369
18CLOCK_20551151_ChIP-Seq_293T_Human1.93198407
19GATA4_25053715_ChIP-Seq_YYC3_Human1.76738323
20CDX2_20551321_ChIP-Seq_CACO-2_Human1.69515966
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68597069
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.67563613
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.66627293
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.63371940
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.61386918
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61067783
27SOX2_20726797_ChIP-Seq_SW620_Human1.60386890
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.53714926
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.51416784
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45999967
31* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45601485
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45565007
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44279563
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35098465
35* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33405094
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32275779
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32275779
38GATA6_25053715_ChIP-Seq_YYC3_Human1.30750833
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.25625734
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25146077
41* IRF8_27001747_Chip-Seq_BMDM_Mouse1.24822524
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.21953534
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21321294
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20927331
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20843208
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20426120
47AR_21909140_ChIP-Seq_LNCAP_Human1.18226258
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18218771
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.17308680
50ZNF263_19887448_ChIP-Seq_K562_Human1.17206427
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16729773
52AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14939668
53* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13627893
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09680822
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07415516
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03878146
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03751353
58SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03751353
59TP53_18474530_ChIP-ChIP_U2OS_Human1.03638865
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.01658366
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01108854
62* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00782004
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98465038
64ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93700914
65HTT_18923047_ChIP-ChIP_STHdh_Human0.93532208
66* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93476732
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92801480
68GATA3_24758297_ChIP-Seq_MCF-7_Human0.91721221
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91205159
70EP300_21415370_ChIP-Seq_HL-1_Mouse0.89362290
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88923102
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88576116
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87637233
74P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86849559
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86795063
76EGR1_19032775_ChIP-ChIP_M12_Human0.84166274
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83877501
78FOXA1_25552417_ChIP-Seq_VCAP_Human0.83753930
79CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82569114
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82342650
81TP53_16413492_ChIP-PET_HCT116_Human0.82021773
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82006106
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80944116
84GATA2_19941826_ChIP-Seq_K562_Human0.80799692
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80328427
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80258663
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.79857442
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77890760
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76738237
90FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76168349
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76158851
92BP1_19119308_ChIP-ChIP_Hs578T_Human0.76069455
93SOX9_24532713_ChIP-Seq_HFSC_Mouse0.73980495
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73412211
95GATA1_19941826_ChIP-Seq_K562_Human0.72508177
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70877285
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70056725
98* TP63_23658742_ChIP-Seq_EP156T_Human0.70011151
99EOMES_21245162_ChIP-Seq_HESCs_Human0.68294190
100RACK7_27058665_Chip-Seq_MCF-7_Human0.68231554
101PIAS1_25552417_ChIP-Seq_VCAP_Human0.67668411
102CDX2_22108803_ChIP-Seq_LS180_Human0.67514316
103BCAT_22108803_ChIP-Seq_LS180_Human0.67370999
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66888659
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66879679
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.66315618
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.65656573
108KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65385678
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.64427278
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.64371915
111CJUN_26792858_Chip-Seq_BT549_Human0.64257864
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63988504
113FOXM1_26456572_ChIP-Seq_MCF-7_Human0.63927598
114BRD4_27068464_Chip-Seq_AML-cells_Mouse0.63229533
115RXRA_24833708_ChIP-Seq_LIVER_Mouse0.62768435
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.62757261
117ESRRB_18555785_Chip-Seq_ESCs_Mouse0.61669484
118CBP_21632823_ChIP-Seq_H3396_Human0.61478227
119HNFA_21074721_ChIP-Seq_CACO-2_Human0.61219929
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.60460952
121ATF3_27146783_Chip-Seq_COLON_Human0.60269644
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.59260678
123VDR_24787735_ChIP-Seq_THP-1_Human0.58160427
124MYB_21317192_ChIP-Seq_ERMYB_Mouse0.57649530
125CEBPB_22108803_ChIP-Seq_LS180_Human0.57345573
126AR_20517297_ChIP-Seq_VCAP_Human0.57058586
127LXR_22292898_ChIP-Seq_THP-1_Human0.56954406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.72774902
2MP0002139_abnormal_hepatobiliary_system6.63232686
3MP0005085_abnormal_gallbladder_physiolo5.05467194
4MP0005365_abnormal_bile_salt4.74304505
5MP0008875_abnormal_xenobiotic_pharmacok4.22028384
6MP0003252_abnormal_bile_duct3.54510156
7MP0003806_abnormal_nucleotide_metabolis3.42654287
8MP0003195_calcinosis3.24601931
9MP0001666_abnormal_nutrient_absorption3.23329568
10MP0010329_abnormal_lipoprotein_level3.01880947
11MP0009840_abnormal_foam_cell3.01850745
12MP0005083_abnormal_biliary_tract2.76361175
13MP0005332_abnormal_amino_acid2.54760804
14MP0002138_abnormal_hepatobiliary_system2.34718546
15MP0010234_abnormal_vibrissa_follicle2.28517458
16MP0003191_abnormal_cellular_cholesterol2.28096734
17MP0005058_abnormal_lysosome_morphology2.27765802
18MP0004019_abnormal_vitamin_homeostasis2.27609533
19MP0002254_reproductive_system_inflammat1.98020656
20MP0000609_abnormal_liver_physiology1.82897625
21MP0009643_abnormal_urine_homeostasis1.80446786
22MP0002118_abnormal_lipid_homeostasis1.78454891
23MP0005319_abnormal_enzyme/_coenzyme1.74438838
24MP0009780_abnormal_chondrocyte_physiolo1.67653070
25MP0003868_abnormal_feces_composition1.65036351
26MP0004272_abnormal_basement_membrane1.57014869
27MP0004043_abnormal_pH_regulation1.51976224
28MP0000604_amyloidosis1.49669442
29MP0004264_abnormal_extraembryonic_tissu1.37403801
30MP0005584_abnormal_enzyme/coenzyme_acti1.35731696
31MP0003705_abnormal_hypodermis_morpholog1.35479723
32MP0003300_gastrointestinal_ulcer1.32934753
33MP0001764_abnormal_homeostasis1.29507952
34MP0003122_maternal_imprinting1.27611212
35MP0005636_abnormal_mineral_homeostasis1.26092965
36MP0003186_abnormal_redox_activity1.24489212
37MP0001756_abnormal_urination1.19326169
38MP0003123_paternal_imprinting1.19085766
39MP0009764_decreased_sensitivity_to1.18181671
40MP0005084_abnormal_gallbladder_morpholo1.17255794
41MP0003879_abnormal_hair_cell1.11904656
42MP0003183_abnormal_peptide_metabolism1.11248530
43MP0000566_synostosis1.07292046
44MP0003656_abnormal_erythrocyte_physiolo1.03039410
45* MP0008469_abnormal_protein_level1.02803430
46MP0000538_abnormal_urinary_bladder1.01014409
47MP0003172_abnormal_lysosome_physiology0.99975659
48MP0004130_abnormal_muscle_cell0.99136996
49MP0000598_abnormal_liver_morphology0.99063788
50MP0003436_decreased_susceptibility_to0.97975977
51MP0002136_abnormal_kidney_physiology0.95521146
52MP0005451_abnormal_body_composition0.95359815
53MP0005166_decreased_susceptibility_to0.94396605
54MP0002078_abnormal_glucose_homeostasis0.92040018
55MP0005670_abnormal_white_adipose0.90934684
56MP0001765_abnormal_ion_homeostasis0.90097126
57MP0009763_increased_sensitivity_to0.88060649
58MP0009697_abnormal_copulation0.87494832
59MP0005409_darkened_coat_color0.87234683
60* MP0009642_abnormal_blood_homeostasis0.87131461
61MP0005220_abnormal_exocrine_pancreas0.83202442
62MP0002876_abnormal_thyroid_physiology0.82745606
63MP0003950_abnormal_plasma_membrane0.81417526
64MP0000003_abnormal_adipose_tissue0.81176383
65MP0003075_altered_response_to0.80957423
66MP0003690_abnormal_glial_cell0.80403203
67MP0001915_intracranial_hemorrhage0.80023459
68MP0005408_hypopigmentation0.79271643
69MP0003303_peritoneal_inflammation0.78115394
70MP0002837_dystrophic_cardiac_calcinosis0.77704994
71MP0002089_abnormal_postnatal_growth/wei0.76914046
72MP0005535_abnormal_body_temperature0.73364185
73MP0005376_homeostasis/metabolism_phenot0.73028500
74MP0005334_abnormal_fat_pad0.72734275
75MP0005464_abnormal_platelet_physiology0.72404425
76MP0002132_abnormal_respiratory_system0.72334378
77MP0005023_abnormal_wound_healing0.72112360
78MP0005379_endocrine/exocrine_gland_phen0.71160494
79MP0002971_abnormal_brown_adipose0.70703836
80MP0008004_abnormal_stomach_pH0.70693136
81MP0010368_abnormal_lymphatic_system0.70622464
82MP0006036_abnormal_mitochondrial_physio0.70327144
83* MP0006082_CNS_inflammation0.70322236
84MP0001661_extended_life_span0.69669418
85MP0010386_abnormal_urinary_bladder0.69120138
86MP0005448_abnormal_energy_balance0.69020945
87MP0001845_abnormal_inflammatory_respons0.68538003
88MP0005167_abnormal_blood-brain_barrier0.67722763
89MP0000639_abnormal_adrenal_gland0.67088745
90MP0005257_abnormal_intraocular_pressure0.67088687
91MP0009765_abnormal_xenobiotic_induced0.66481360
92MP0001881_abnormal_mammary_gland0.66180395
93MP0002928_abnormal_bile_duct0.65803766
94MP0001663_abnormal_digestive_system0.63567989
95MP0003638_abnormal_response/metabolism_0.63109416
96MP0003941_abnormal_skin_development0.62414683
97MP0000013_abnormal_adipose_tissue0.61894100
98MP0010155_abnormal_intestine_physiology0.61115366
99MP0003283_abnormal_digestive_organ0.61092349
100MP0002896_abnormal_bone_mineralization0.61048246
101MP0002419_abnormal_innate_immunity0.60921298
102MP0004782_abnormal_surfactant_physiolog0.60816729
103MP0003329_amyloid_beta_deposits0.60676247
104MP0005165_increased_susceptibility_to0.58295688
105MP0005310_abnormal_salivary_gland0.58033150
106MP0009785_altered_susceptibility_to0.57888950
107MP0004947_skin_inflammation0.57630984
108MP0005647_abnormal_sex_gland0.56789323
109MP0005666_abnormal_adipose_tissue0.56612099
110MP0005395_other_phenotype0.56433061
111MP0005381_digestive/alimentary_phenotyp0.56300651
112MP0001944_abnormal_pancreas_morphology0.55393653
113MP0002909_abnormal_adrenal_gland0.54151091
114MP0003453_abnormal_keratinocyte_physiol0.54071111
115MP0005266_abnormal_metabolism0.53978829
116MP0004883_abnormal_blood_vessel0.53109696
117MP0002693_abnormal_pancreas_physiology0.52809130
118MP0001664_abnormal_digestion0.52788583
119MP0000462_abnormal_digestive_system0.52746845
120MP0003953_abnormal_hormone_level0.52523245
121MP0005330_cardiomyopathy0.52043444
122MP0000230_abnormal_systemic_arterial0.51823978
123MP0010678_abnormal_skin_adnexa0.51594987
124MP0005164_abnormal_response_to0.50330442
125MP0003724_increased_susceptibility_to0.50078043
126MP0003566_abnormal_cell_adhesion0.50071263
127MP0002090_abnormal_vision0.49688347
128MP0004147_increased_porphyrin_level0.49623268
129MP0002168_other_aberrant_phenotype0.49536534
130MP0001270_distended_abdomen0.48286499
131MP0000477_abnormal_intestine_morphology0.47918423
132MP0002796_impaired_skin_barrier0.46760161
133MP0010352_gastrointestinal_tract_polyps0.43347446
134MP0006054_spinal_hemorrhage0.41171589
135MP0005367_renal/urinary_system_phenotyp0.41162928
136MP0000516_abnormal_urinary_system0.41162928
137MP0003718_maternal_effect0.39947185
138MP0004270_analgesia0.38646476
139MP0000678_abnormal_parathyroid_gland0.36889158

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.50788985
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.44999866
3Xanthomatosis (HP:0000991)5.26294191
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.04883610
5Deep venous thrombosis (HP:0002625)4.96254668
6Hypobetalipoproteinemia (HP:0003563)4.71233070
7Abnormality of glutamine family amino acid metabolism (HP:0010902)4.38773214
8Prolonged partial thromboplastin time (HP:0003645)4.28932653
9Hyperlipoproteinemia (HP:0010980)4.15099595
10Epidermoid cyst (HP:0200040)3.85722067
11Complement deficiency (HP:0004431)3.77660649
12Fat malabsorption (HP:0002630)3.74143422
13Hypolipoproteinemia (HP:0010981)3.71487540
14Hyperammonemia (HP:0001987)3.70639543
15Ketosis (HP:0001946)3.67693540
16Hypoglycemic coma (HP:0001325)3.67159783
17Joint hemorrhage (HP:0005261)3.63704986
18Hyperglycinuria (HP:0003108)3.63042397
19Conjugated hyperbilirubinemia (HP:0002908)3.60571038
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.57834250
21Abnormality of the common coagulation pathway (HP:0010990)3.45033430
22Hypercholesterolemia (HP:0003124)3.31770043
23Ketoacidosis (HP:0001993)3.31357922
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.31279161
25Hypoalphalipoproteinemia (HP:0003233)3.26662797
26Abnormality of serine family amino acid metabolism (HP:0010894)3.25547431
27Abnormality of glycine metabolism (HP:0010895)3.25547431
28Vacuolated lymphocytes (HP:0001922)3.24474158
29Hyperglycinemia (HP:0002154)3.21906766
30Abnormality of purine metabolism (HP:0004352)3.20551741
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.18044146
32Abnormality of the intrinsic pathway (HP:0010989)3.12274385
33Recurrent gram-negative bacterial infections (HP:0005420)3.12115641
34Gout (HP:0001997)3.06709782
35Myocardial infarction (HP:0001658)3.05563052
36Abnormality of fatty-acid metabolism (HP:0004359)2.95983969
37Mitral stenosis (HP:0001718)2.89937805
38Right ventricular cardiomyopathy (HP:0011663)2.87418745
39Skin nodule (HP:0200036)2.87346524
40Hemorrhage of the eye (HP:0011885)2.86339308
41Abnormality of nucleobase metabolism (HP:0010932)2.85369008
42Abnormality of complement system (HP:0005339)2.81686351
43Abnormal tarsal ossification (HP:0008369)2.76990205
44Systemic lupus erythematosus (HP:0002725)2.74027836
45Hydroxyprolinuria (HP:0003080)2.73524052
46Abnormality of proline metabolism (HP:0010907)2.73524052
47Esophageal varix (HP:0002040)2.72041425
48Urinary glycosaminoglycan excretion (HP:0003541)2.71370941
49Mucopolysacchariduria (HP:0008155)2.71370941
50Dysostosis multiplex (HP:0000943)2.65346480
51Malnutrition (HP:0004395)2.63907346
52Steatorrhea (HP:0002570)2.62642061
53Abnormality of vitamin metabolism (HP:0100508)2.61683586
54Hepatocellular carcinoma (HP:0001402)2.59655686
55Rickets (HP:0002748)2.58970617
56Abnormality of methionine metabolism (HP:0010901)2.56635121
57Nephritis (HP:0000123)2.55374280
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54692410
59Abnormality of polysaccharide metabolism (HP:0011012)2.52211447
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52211447
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52211447
62Hypoglycemic seizures (HP:0002173)2.51878325
63Abnormality of carpal bone ossification (HP:0006257)2.51155136
64Metabolic acidosis (HP:0001942)2.50756910
65Vascular calcification (HP:0004934)2.50621088
66Hyperbilirubinemia (HP:0002904)2.46855335
67Hypophosphatemic rickets (HP:0004912)2.46749855
68Sensorimotor neuropathy (HP:0007141)2.39194767
69Glomerulonephritis (HP:0000099)2.37905854
70Nausea (HP:0002018)2.36724292
71Flat acetabular roof (HP:0003180)2.36407091
72Menorrhagia (HP:0000132)2.33310313
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32429863
74Dicarboxylic aciduria (HP:0003215)2.32429863
75Glycosuria (HP:0003076)2.30119851
76Abnormality of urine glucose concentration (HP:0011016)2.30119851
77Lethargy (HP:0001254)2.29591658
78Widely patent fontanelles and sutures (HP:0004492)2.28938329
79Acanthocytosis (HP:0001927)2.27799310
80Generalized aminoaciduria (HP:0002909)2.27630504
81Proximal tubulopathy (HP:0000114)2.25613475
82Pancreatitis (HP:0001733)2.25539601
83Ileus (HP:0002595)2.24903806
84Axonal loss (HP:0003447)2.24180587
85Hyperuricemia (HP:0002149)2.21919838
86Increased purine levels (HP:0004368)2.21919838
87Cardiovascular calcification (HP:0011915)2.17648725
88Hyperinsulinemic hypoglycemia (HP:0000825)2.15575528
89Focal segmental glomerulosclerosis (HP:0000097)2.15184532
90Hyperphosphaturia (HP:0003109)2.15091656
91Abnormality of pyrimidine metabolism (HP:0004353)2.15003543
92Vomiting (HP:0002013)2.14413776
93Facial shape deformation (HP:0011334)2.14325811
94Potter facies (HP:0002009)2.14325811
95Late onset (HP:0003584)2.14290081
96Delayed CNS myelination (HP:0002188)2.13284264
97Osteomalacia (HP:0002749)2.11113921
98Irritability (HP:0000737)2.11057850
99Hyperglycemia (HP:0003074)2.10942013
100Hypothermia (HP:0002045)2.10737599
101Pigmentary retinal degeneration (HP:0001146)2.09695708
102Abnormality of serum amino acid levels (HP:0003112)2.08730376
103Alkalosis (HP:0001948)2.05985494
104Palpitations (HP:0001962)2.03967481
105Cerebral edema (HP:0002181)2.02895208
106Amyloidosis (HP:0011034)2.02218741
107Abnormality of transition element cation homeostasis (HP:0011030)2.01389450
108Abnormal urine phosphate concentration (HP:0012599)2.01160761
109Abdominal distention (HP:0003270)2.00455762
110Glomerulosclerosis (HP:0000096)2.00086497
111Abnormal gallbladder morphology (HP:0012437)1.97599288
112Gingival bleeding (HP:0000225)1.97473052
113Global brain atrophy (HP:0002283)1.97303934
114Protuberant abdomen (HP:0001538)1.97285324
115Spastic diplegia (HP:0001264)1.96447269
116Abnormal enzyme/coenzyme activity (HP:0012379)1.95666172
117Joint swelling (HP:0001386)1.94844971
118Hypotension (HP:0002615)1.91281664
119Cholelithiasis (HP:0001081)1.90973764
120Symptomatic seizures (HP:0011145)1.90608720
121Increased cerebral lipofuscin (HP:0011813)1.90107823
122Spontaneous abortion (HP:0005268)1.89507692
123Abnormal hand bone ossification (HP:0010660)1.85333571
124Purpura (HP:0000979)1.81542082
125Hypophosphatemia (HP:0002148)1.79550146
126Pancreatic islet-cell hyperplasia (HP:0004510)1.78521048
127Abnormality of vitamin B metabolism (HP:0004340)1.78498606
128Abnormality of the Achilles tendon (HP:0005109)1.76288775
129Exocrine pancreatic insufficiency (HP:0001738)1.74098095
130Abnormal ossification of hand bones (HP:0005921)1.70984093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.51599317
2BCKDK3.55174068
3MST1R3.18517270
4ERN13.16292088
5TAOK33.02489211
6MAPK152.68764988
7ACVR1B2.65030030
8PBK2.56227295
9MAP3K122.48971463
10MST42.26772519
11LMTK22.15614549
12ERBB42.12329851
13PTK62.09681424
14MAP3K22.01569730
15FGFR42.01363069
16PKN22.00334535
17INSRR2.00155119
18TRIB31.90794131
19IRAK31.71422419
20CASK1.68261626
21TBK11.66857467
22RIPK41.65830735
23SIK11.63862029
24BCR1.63835486
25EPHA21.60147514
26WNK41.51415192
27RIPK11.51227919
28TYK21.48265450
29MAP3K141.40060042
30ICK1.36765940
31WNK31.35694972
32PIK3CG1.30354459
33FGFR21.30060501
34ABL21.28350143
35NEK91.20654885
36MAP2K21.20485465
37NEK11.18771840
38MAP3K31.14549145
39CSK1.14444829
40PRKG21.13824966
41SCYL21.11306320
42MET1.08424533
43PTK21.06287343
44JAK21.05501544
45PHKG21.05153621
46PHKG11.05153621
47LATS11.04734036
48JAK11.02140604
49PAK41.00301740
50TTN0.99057654
51KSR20.98908908
52MYLK0.97230459
53STK390.96804697
54FGFR10.96293144
55EIF2AK30.93296517
56AKT30.92439401
57FER0.88857894
58MAP2K60.86281192
59TRPM70.83270970
60GRK60.82844177
61MAP2K10.82324933
62NUAK10.81678160
63EPHB10.80994855
64BMX0.80847304
65OXSR10.80755393
66STK240.79545491
67TESK10.78832037
68MAP3K10.78720352
69ERBB20.77578671
70DDR20.76121760
71PDPK10.74433146
72CAMK2G0.72476202
73PRKAA20.72242044
74NME20.71639596
75PDK20.71506275
76FLT30.71412684
77PAK30.71218129
78DAPK20.71129313
79MAPK110.70957613
80STK38L0.70363583
81MAP3K90.69300431
82TNIK0.68419650
83MAP2K40.64440058
84LATS20.63231097
85MAP3K130.61832327
86MAP3K110.59641468
87EGFR0.59370497
88LIMK10.59300186
89NLK0.59088563
90CDK60.57910449
91IRAK10.57663750
92EIF2AK10.57396617
93WNK10.57077478
94ARAF0.55841217
95CAMK2D0.54693013
96IKBKE0.54221754
97STK380.54178105
98EPHA40.51205840
99DAPK10.51192790
100DYRK1B0.49811615
101GSK3A0.48311184
102PDK30.47669112
103PDK40.47669112
104CDK120.47045508
105GRK10.46948038
106CDK80.46103300
107CAMK1D0.45665303
108PRKACG0.45565500
109ERBB30.45117677
110MAP3K50.44593160
111PRKCE0.44152717
112TGFBR20.43847560
113FGR0.43353932
114MAP3K70.43171527
115PIK3CA0.41841766
116BRSK20.41582157
117PRKCQ0.41479733
118MAP3K60.41106657
119MAP2K30.40935945
120PDK10.40087599
121PRKAA10.39542292
122IRAK40.39186149
123PRKCZ0.38865407
124MATK0.38182090
125LRRK20.37753741
126SRC0.37060740
127ABL10.36441612
128RET0.36160597
129PRKG10.35377634
130MELK0.35096771
131IGF1R0.34566341
132PDGFRA0.34123611
133EPHA30.33294530
134SGK30.31422301
135NTRK30.31033189
136OBSCN0.30605739
137SGK2230.30148313
138SGK4940.30148313
139MAPKAPK30.29840104
140PRKCA0.29665485
141PRKCD0.28851105
142FGFR30.28681408

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.41747377
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27062558
3Nitrogen metabolism_Homo sapiens_hsa009103.00403595
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83138263
5Arginine biosynthesis_Homo sapiens_hsa002202.69905006
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49941209
7Tryptophan metabolism_Homo sapiens_hsa003802.48832839
8Fatty acid degradation_Homo sapiens_hsa000712.45206607
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31960894
10Complement and coagulation cascades_Homo sapiens_hsa046102.26786834
11Sulfur metabolism_Homo sapiens_hsa009202.18345489
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18224050
13Histidine metabolism_Homo sapiens_hsa003402.13674735
14Butanoate metabolism_Homo sapiens_hsa006502.02140174
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96284361
16Propanoate metabolism_Homo sapiens_hsa006401.93273364
17Fat digestion and absorption_Homo sapiens_hsa049751.88390541
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87959154
19Peroxisome_Homo sapiens_hsa041461.87902594
20PPAR signaling pathway_Homo sapiens_hsa033201.82750162
21Caffeine metabolism_Homo sapiens_hsa002321.79695028
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75748582
23Bile secretion_Homo sapiens_hsa049761.74284027
24beta-Alanine metabolism_Homo sapiens_hsa004101.74113986
25Staphylococcus aureus infection_Homo sapiens_hsa051501.71817478
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.70589055
27Starch and sucrose metabolism_Homo sapiens_hsa005001.69933239
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68348570
29Chemical carcinogenesis_Homo sapiens_hsa052041.65650267
30Fatty acid metabolism_Homo sapiens_hsa012121.58113473
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56007145
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.41355792
33Pyruvate metabolism_Homo sapiens_hsa006201.36779860
34Phenylalanine metabolism_Homo sapiens_hsa003601.35949852
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34326952
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.33903314
37Selenocompound metabolism_Homo sapiens_hsa004501.31170408
38Folate biosynthesis_Homo sapiens_hsa007901.30894465
39Vitamin digestion and absorption_Homo sapiens_hsa049771.30691845
40Retinol metabolism_Homo sapiens_hsa008301.27528923
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22846266
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19609792
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18082330
44Carbon metabolism_Homo sapiens_hsa012001.14995691
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12468085
46ABC transporters_Homo sapiens_hsa020101.10830462
47Steroid biosynthesis_Homo sapiens_hsa001001.08720172
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04622500
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02208539
50Tyrosine metabolism_Homo sapiens_hsa003501.00384321
51Arginine and proline metabolism_Homo sapiens_hsa003300.97985764
52Renin-angiotensin system_Homo sapiens_hsa046140.95614734
53Glycerolipid metabolism_Homo sapiens_hsa005610.87147204
54Mineral absorption_Homo sapiens_hsa049780.85649630
55Glutathione metabolism_Homo sapiens_hsa004800.84449098
56Fatty acid elongation_Homo sapiens_hsa000620.84036643
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83570087
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83361400
59Biosynthesis of amino acids_Homo sapiens_hsa012300.80328003
60Arachidonic acid metabolism_Homo sapiens_hsa005900.79963933
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.78123899
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77677670
63Sphingolipid metabolism_Homo sapiens_hsa006000.75948700
64Lysosome_Homo sapiens_hsa041420.74461503
65Galactose metabolism_Homo sapiens_hsa000520.73797768
66Other glycan degradation_Homo sapiens_hsa005110.71675173
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66858053
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.63128635
69Sulfur relay system_Homo sapiens_hsa041220.61899148
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.56567136
71Fructose and mannose metabolism_Homo sapiens_hsa000510.51276245
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51008987
73Pentose phosphate pathway_Homo sapiens_hsa000300.50767474
74Lysine degradation_Homo sapiens_hsa003100.50356613
75N-Glycan biosynthesis_Homo sapiens_hsa005100.41676250
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40531568
77Metabolic pathways_Homo sapiens_hsa011000.40076484
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39958969
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39487983
80Insulin resistance_Homo sapiens_hsa049310.37469086
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.35448206
82Collecting duct acid secretion_Homo sapiens_hsa049660.34322706
83Prion diseases_Homo sapiens_hsa050200.33729527
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32047379
85Fatty acid biosynthesis_Homo sapiens_hsa000610.32001144
86Ether lipid metabolism_Homo sapiens_hsa005650.31723290
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31081687
88Thyroid hormone synthesis_Homo sapiens_hsa049180.30617646
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27536653
90Protein digestion and absorption_Homo sapiens_hsa049740.26544510
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25329323
92Vibrio cholerae infection_Homo sapiens_hsa051100.23878338
93Circadian rhythm_Homo sapiens_hsa047100.22643004
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21589584
95Linoleic acid metabolism_Homo sapiens_hsa005910.20554235
96Legionellosis_Homo sapiens_hsa051340.19477694
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.16077715
98Phagosome_Homo sapiens_hsa041450.14216317
99Pertussis_Homo sapiens_hsa051330.11668148
100Hepatitis C_Homo sapiens_hsa051600.10776122
101Amoebiasis_Homo sapiens_hsa051460.10695975
102Pancreatic secretion_Homo sapiens_hsa049720.10672956
103Oxidative phosphorylation_Homo sapiens_hsa001900.08764704
104African trypanosomiasis_Homo sapiens_hsa051430.07288129
105Tuberculosis_Homo sapiens_hsa051520.04781285
106Type II diabetes mellitus_Homo sapiens_hsa049300.04374938
107AMPK signaling pathway_Homo sapiens_hsa041520.03434090
108Glucagon signaling pathway_Homo sapiens_hsa049220.03409124
109Vitamin B6 metabolism_Homo sapiens_hsa007500.02283403
110ECM-receptor interaction_Homo sapiens_hsa04512-0.0099884

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