RNF114

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41541419
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.41541419
3antigen processing and presentation of endogenous antigen (GO:0019883)4.96545983
4positive regulation of gamma-delta T cell activation (GO:0046645)4.25560246
5Golgi transport vesicle coating (GO:0048200)4.21875667
6COPI coating of Golgi vesicle (GO:0048205)4.21875667
7piRNA metabolic process (GO:0034587)4.20231635
8proteasome assembly (GO:0043248)4.13737671
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.01251165
10immunoglobulin mediated immune response (GO:0016064)3.88580398
11base-excision repair, AP site formation (GO:0006285)3.80453684
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.71995112
13regulation of RIG-I signaling pathway (GO:0039535)3.62228788
14NIK/NF-kappaB signaling (GO:0038061)3.59906188
15response to type I interferon (GO:0034340)3.52481904
16antigen processing and presentation via MHC class Ib (GO:0002475)3.51992328
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50305448
18cellular response to type I interferon (GO:0071357)3.50153756
19type I interferon signaling pathway (GO:0060337)3.50153756
20B cell mediated immunity (GO:0019724)3.45809761
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.33469876
22positive regulation of humoral immune response (GO:0002922)3.27385416
23ribosome assembly (GO:0042255)3.24714404
24histone H2A monoubiquitination (GO:0035518)3.24347981
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24280580
26regulation of gamma-delta T cell differentiation (GO:0045586)3.24215468
27protein maturation by protein folding (GO:0022417)3.21466652
28regulation of type I interferon-mediated signaling pathway (GO:0060338)3.19901536
29regulation of interleukin-12 biosynthetic process (GO:0045075)3.17539585
30regulation of gamma-delta T cell activation (GO:0046643)3.16372870
31regulation of response to interferon-gamma (GO:0060330)3.16008463
32regulation of cellular amino acid metabolic process (GO:0006521)3.08237521
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06089134
34regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.04563182
35proline biosynthetic process (GO:0006561)3.04483646
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02932183
37T cell migration (GO:0072678)3.01823158
38formation of translation preinitiation complex (GO:0001731)3.01158785
39negative regulation of ligase activity (GO:0051352)2.99905797
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99905797
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99875333
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99063474
43regulation of female gonad development (GO:2000194)2.98946165
44regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.96907765
45GDP-mannose metabolic process (GO:0019673)2.95112596
46pentose-phosphate shunt (GO:0006098)2.95050752
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.92640855
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92416672
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92416672
50histone H2A ubiquitination (GO:0033522)2.92368800
51positive regulation of interferon-alpha production (GO:0032727)2.90479685
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88458415
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88458415
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88458415
55mitotic chromosome condensation (GO:0007076)2.86848845
56Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86515051
57interferon-gamma-mediated signaling pathway (GO:0060333)2.86432900
58signal transduction involved in DNA damage checkpoint (GO:0072422)2.86020593
59signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86020593
60negative thymic T cell selection (GO:0045060)2.85221453
61ribosomal small subunit assembly (GO:0000028)2.84339899
62negative T cell selection (GO:0043383)2.82258331
63cellular response to interferon-beta (GO:0035458)2.81253207
64pyrimidine nucleotide catabolic process (GO:0006244)2.78988465
65signal transduction involved in cell cycle checkpoint (GO:0072395)2.78162857
66citrulline biosynthetic process (GO:0019240)2.77400669
67NADPH regeneration (GO:0006740)2.76081905
68telomere maintenance via semi-conservative replication (GO:0032201)2.74946029
69regulation of interferon-alpha production (GO:0032647)2.74336854
70response to interferon-beta (GO:0035456)2.73235223
71protein K6-linked ubiquitination (GO:0085020)2.70431191
72attachment of spindle microtubules to kinetochore (GO:0008608)2.68630034
73purine deoxyribonucleotide catabolic process (GO:0009155)2.68423783
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.66920068
75mitotic metaphase plate congression (GO:0007080)2.65030687
76positive regulation of antigen processing and presentation (GO:0002579)2.64728636
77regulation of B cell receptor signaling pathway (GO:0050855)2.63659675
78myeloid dendritic cell differentiation (GO:0043011)2.62442743
79pinocytosis (GO:0006907)2.60686946
80cellular response to virus (GO:0098586)2.59792844
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58427133
82myeloid dendritic cell activation (GO:0001773)2.58006184
83positive regulation of ligase activity (GO:0051351)2.57737599
84defense response to protozoan (GO:0042832)2.56064119
85JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.54545862
86positive regulation of B cell differentiation (GO:0045579)2.54417785
87negative regulation of meiosis (GO:0045835)2.53810530
88pentose metabolic process (GO:0019321)2.53456805
89positive regulation of Cdc42 GTPase activity (GO:0043089)2.53252655
90sequestering of actin monomers (GO:0042989)2.52680673
91regulation of B cell differentiation (GO:0045577)2.52120739
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.51880492
93deoxyribonucleotide catabolic process (GO:0009264)2.49705960
94negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.49251919
95antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.48322106
96ribosomal large subunit biogenesis (GO:0042273)2.45329125
97regulation of hypersensitivity (GO:0002883)2.44739968
98establishment of viral latency (GO:0019043)2.43218581
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42834586
100positive regulation of interferon-beta production (GO:0032728)2.40669216
101positive thymic T cell selection (GO:0045059)2.40629523
102ribosomal small subunit biogenesis (GO:0042274)2.38386959
103negative regulation of B cell apoptotic process (GO:0002903)2.37630249
104deoxyribose phosphate catabolic process (GO:0046386)2.37254126
105regulation of ubiquitin-protein transferase activity (GO:0051438)2.36750886
106leukocyte aggregation (GO:0070486)2.36518826
107thymic T cell selection (GO:0045061)2.35829054
108telomere maintenance via recombination (GO:0000722)2.35730754
109nucleotide salvage (GO:0043173)2.35480735
110ribosome biogenesis (GO:0042254)2.34447520
111positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.34441298
112spliceosomal tri-snRNP complex assembly (GO:0000244)2.34262022
113response to protozoan (GO:0001562)2.33236463
114chaperone mediated protein folding requiring cofactor (GO:0051085)2.33119527
115regulation of alpha-beta T cell proliferation (GO:0046640)2.32562407
116establishment of chromosome localization (GO:0051303)2.32553033
117folic acid-containing compound biosynthetic process (GO:0009396)2.32036202
118ribonucleoprotein complex biogenesis (GO:0022613)2.31888708
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.30389575
120regulation of ligase activity (GO:0051340)2.30351271
121positive regulation of keratinocyte differentiation (GO:0045618)2.29532666
122mitotic nuclear envelope disassembly (GO:0007077)2.29357464
123DNA strand elongation involved in DNA replication (GO:0006271)2.29043662
124DNA methylation involved in gamete generation (GO:0043046)2.28695076
125gene silencing by RNA (GO:0031047)2.28396141
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.27453937
127glucose catabolic process (GO:0006007)2.27268184
128metaphase plate congression (GO:0051310)2.26600288
129DNA deamination (GO:0045006)2.26436979
130regulation of cellular amine metabolic process (GO:0033238)2.26328381
131positive regulation of T cell apoptotic process (GO:0070234)2.25210172
132mitotic nuclear envelope reassembly (GO:0007084)2.24331348
133nuclear envelope reassembly (GO:0031468)2.24331348
134negative regulation of protein ubiquitination (GO:0031397)2.23918525
135NADH metabolic process (GO:0006734)2.23238299
136interferon-gamma production (GO:0032609)2.22623920
137negative regulation of viral genome replication (GO:0045071)2.21809363
138DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.21746382
139G1/S transition of mitotic cell cycle (GO:0000082)2.20885974
140cell cycle G1/S phase transition (GO:0044843)2.20885974
141pyrimidine nucleoside salvage (GO:0043097)2.20544689
142pyrimidine-containing compound salvage (GO:0008655)2.20544689
143DNA strand elongation (GO:0022616)2.20529699
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.20127921
145positive regulation of cell cycle arrest (GO:0071158)2.20127562
146response to interferon-alpha (GO:0035455)2.20044995
147establishment of integrated proviral latency (GO:0075713)2.19901903
148positive regulation of isotype switching (GO:0045830)2.19805458
149negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.19229800
150regulation of translation in response to stress (GO:0043555)2.18644179
151cellular response to interferon-gamma (GO:0071346)2.18105277
152regulation of histone H3-K27 methylation (GO:0061085)2.17456606
153natural killer cell mediated immunity (GO:0002228)2.16995906
154natural killer cell mediated cytotoxicity (GO:0042267)2.16995906
155transcription-coupled nucleotide-excision repair (GO:0006283)2.16541200
156nucleobase-containing small molecule interconversion (GO:0015949)2.16365363
157T cell apoptotic process (GO:0070231)2.16103662
158protein targeting to mitochondrion (GO:0006626)2.15853761
159regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.14878705
160purine nucleotide salvage (GO:0032261)2.14822178
161anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.14046645
162regulation of translational termination (GO:0006449)2.13783807
163positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.13720653
164response to peptidoglycan (GO:0032494)2.13551866
165regulation of spindle organization (GO:0090224)2.13464715
166lymphocyte mediated immunity (GO:0002449)2.13304531
167T cell selection (GO:0045058)2.13133179
168regulation of sister chromatid cohesion (GO:0007063)2.11697111
169meiotic chromosome segregation (GO:0045132)2.11323879
170negative regulation of type I interferon production (GO:0032480)2.10917044
171positive regulation of interleukin-12 production (GO:0032735)2.10858562
172regulation of antigen processing and presentation (GO:0002577)2.10645790
173regulation of defense response to virus by host (GO:0050691)2.10589301
174spliceosomal snRNP assembly (GO:0000387)2.10211605
175hepatocyte apoptotic process (GO:0097284)2.10205906
176signal transduction in response to DNA damage (GO:0042770)2.07844705
177deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.07233540
178pseudouridine synthesis (GO:0001522)2.06444778
179mitotic recombination (GO:0006312)2.05903636
180autophagic vacuole fusion (GO:0000046)2.05859849
181metallo-sulfur cluster assembly (GO:0031163)2.05624797
182iron-sulfur cluster assembly (GO:0016226)2.05624797
183negative regulation of myeloid cell apoptotic process (GO:0033033)2.05547634
184nucleoside salvage (GO:0043174)2.05519630
185regulation of mitochondrial translation (GO:0070129)2.05249781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.45950861
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.00197106
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22874260
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.00344722
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.97767577
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.68403995
7MYC_22102868_ChIP-Seq_BL_Human2.46018700
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43257210
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42040140
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38651390
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28577799
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13343076
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08109903
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05334877
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.01044683
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.96559830
17ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.96462380
18ZNF263_19887448_ChIP-Seq_K562_Human1.93549285
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91573213
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86486919
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86361108
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.83426841
23VDR_21846776_ChIP-Seq_THP-1_Human1.82376608
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81881645
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79215827
26MYB_26560356_Chip-Seq_TH2_Human1.76996124
27* SPI1_23547873_ChIP-Seq_NB4_Human1.76810783
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.75282232
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74703573
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71573363
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69325019
32VDR_23849224_ChIP-Seq_CD4+_Human1.68714194
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.66121180
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65806682
35MAF_26560356_Chip-Seq_TH1_Human1.65106152
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63619379
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62782126
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60704894
39* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60269640
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59667384
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58091777
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57841510
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.56717871
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.56562417
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55222371
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.55025517
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.54900242
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54577165
49* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54335219
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51725476
51UTX_26944678_Chip-Seq_JUKART_Human1.51505226
52* GABP_19822575_ChIP-Seq_HepG2_Human1.50745216
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50228554
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49860601
55MYB_26560356_Chip-Seq_TH1_Human1.49558650
56* FOXP3_21729870_ChIP-Seq_TREG_Human1.49520741
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47861884
58* CIITA_25753668_ChIP-Seq_RAJI_Human1.47065067
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46133688
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45813340
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45422519
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45417845
63XRN2_22483619_ChIP-Seq_HELA_Human1.43780182
64* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43462397
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40736340
66SCL_19346495_ChIP-Seq_HPC-7_Human1.39132354
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37755865
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36513744
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.36368329
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35268116
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33808307
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30797916
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27920591
74MAF_26560356_Chip-Seq_TH2_Human1.26924195
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26787813
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26428050
77TTF2_22483619_ChIP-Seq_HELA_Human1.25972043
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25882772
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25821413
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25806600
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.24916845
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24427588
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24321347
84TCF7_22412390_ChIP-Seq_EML_Mouse1.23314751
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23166934
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19573966
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.18678007
88DCP1A_22483619_ChIP-Seq_HELA_Human1.18507063
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18407483
90VDR_24763502_ChIP-Seq_THP-1_Human1.18317718
91MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18192609
92GATA3_27048872_Chip-Seq_THYMUS_Human1.18126328
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17995032
94KDM5A_27292631_Chip-Seq_BREAST_Human1.17126332
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14902496
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14682023
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14443022
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12803017
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10937540
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09967486
101TFEB_21752829_ChIP-Seq_HELA_Human1.09681114
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08805114
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08651920
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08472109
105RUNX_20019798_ChIP-Seq_JUKART_Human1.08277049
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08045278
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08022123
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07016465
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06671319
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05354998
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04804801
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04060066
113ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03677643
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03603107
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03009095
116* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02140995
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00499399
118AR_21909140_ChIP-Seq_LNCAP_Human0.99968571
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99906918
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98920522
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97889886
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97113326
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96646815
124* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95366753
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94458657
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93034279
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92876584
128* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92237871
129RACK7_27058665_Chip-Seq_MCF-7_Human0.91629593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.97655938
2MP0000685_abnormal_immune_system3.36982143
3MP0003806_abnormal_nucleotide_metabolis3.20972069
4MP0009785_altered_susceptibility_to3.02326922
5MP0005671_abnormal_response_to3.02291148
6MP0003763_abnormal_thymus_physiology2.87456138
7MP0003693_abnormal_embryo_hatching2.60235850
8MP0001800_abnormal_humoral_immune2.39050001
9MP0001790_abnormal_immune_system2.32303902
10MP0005387_immune_system_phenotype2.32303902
11MP0005025_abnormal_response_to2.26438024
12MP0003436_decreased_susceptibility_to2.21816508
13MP0003646_muscle_fatigue2.21418440
14MP0002723_abnormal_immune_serum2.15408013
15MP0002452_abnormal_antigen_presenting2.13449513
16MP0002398_abnormal_bone_marrow2.13441144
17MP0005000_abnormal_immune_tolerance2.10277696
18MP0009333_abnormal_splenocyte_physiolog2.07528328
19MP0002396_abnormal_hematopoietic_system2.07211777
20MP0003077_abnormal_cell_cycle2.07138835
21MP0002420_abnormal_adaptive_immunity2.06143337
22MP0001819_abnormal_immune_cell2.06115483
23MP0002148_abnormal_hypersensitivity_rea1.96988276
24MP0003718_maternal_effect1.93723719
25MP0010094_abnormal_chromosome_stability1.91086861
26MP0000716_abnormal_immune_system1.88781498
27MP0004957_abnormal_blastocyst_morpholog1.87464516
28MP0000689_abnormal_spleen_morphology1.85675089
29MP0006082_CNS_inflammation1.85398926
30MP0009840_abnormal_foam_cell1.84482885
31MP0008877_abnormal_DNA_methylation1.84415425
32MP0002419_abnormal_innate_immunity1.75854967
33MP0002722_abnormal_immune_system1.73773649
34MP0004510_myositis1.72956161
35MP0002405_respiratory_system_inflammati1.72842158
36MP0002166_altered_tumor_susceptibility1.71356462
37MP0010155_abnormal_intestine_physiology1.66876369
38MP0002429_abnormal_blood_cell1.65696237
39MP0005397_hematopoietic_system_phenotyp1.64233247
40MP0001545_abnormal_hematopoietic_system1.64233247
41MP0005310_abnormal_salivary_gland1.63430669
42MP0005464_abnormal_platelet_physiology1.61316211
43MP0001873_stomach_inflammation1.60293217
44MP0004233_abnormal_muscle_weight1.60157508
45MP0003724_increased_susceptibility_to1.58259545
46MP0003111_abnormal_nucleus_morphology1.56591669
47MP0004808_abnormal_hematopoietic_stem1.53500885
48MP0000703_abnormal_thymus_morphology1.50966276
49MP0002006_tumorigenesis1.50189345
50MP0004947_skin_inflammation1.49453965
51MP0000490_abnormal_crypts_of1.48635558
52MP0001845_abnormal_inflammatory_respons1.46574706
53MP0004264_abnormal_extraembryonic_tissu1.43817510
54MP0005451_abnormal_body_composition1.40624216
55MP0002019_abnormal_tumor_incidence1.40575046
56MP0002138_abnormal_hepatobiliary_system1.38254786
57MP0006036_abnormal_mitochondrial_physio1.38005598
58MP0008469_abnormal_protein_level1.35290304
59MP0008007_abnormal_cellular_replicative1.29910790
60MP0001853_heart_inflammation1.29451063
61MP0010234_abnormal_vibrissa_follicle1.28420901
62MP0008058_abnormal_DNA_repair1.24617643
63MP0003191_abnormal_cellular_cholesterol1.24364283
64MP0000465_gastrointestinal_hemorrhage1.23903737
65MP0005075_abnormal_melanosome_morpholog1.23628464
66MP0009278_abnormal_bone_marrow1.23290849
67MP0000358_abnormal_cell_content/1.18899889
68MP0005360_urolithiasis1.16123864
69MP0003172_abnormal_lysosome_physiology1.15462668
70MP0003303_peritoneal_inflammation1.15057752
71MP0003183_abnormal_peptide_metabolism1.13838122
72MP0001119_abnormal_female_reproductive1.12999123
73MP0001666_abnormal_nutrient_absorption1.12136421
74MP0000858_altered_metastatic_potential1.11653876
75MP0006035_abnormal_mitochondrial_morpho1.11447193
76MP0008260_abnormal_autophagy1.10540386
77MP0002796_impaired_skin_barrier1.10075275
78MP0002254_reproductive_system_inflammat1.09522828
79MP0005501_abnormal_skin_physiology1.09250027
80MP0001881_abnormal_mammary_gland1.08875713
81MP0002877_abnormal_melanocyte_morpholog1.08521115
82MP0005319_abnormal_enzyme/_coenzyme1.06993216
83MP0005408_hypopigmentation1.06653841
84MP0003866_abnormal_defecation1.05025976
85MP0009764_decreased_sensitivity_to1.01854310
86MP0002139_abnormal_hepatobiliary_system1.01073619
87MP0005584_abnormal_enzyme/coenzyme_acti0.99494644
88MP0010307_abnormal_tumor_latency0.95870107
89MP0010352_gastrointestinal_tract_polyps0.95508955
90MP0003075_altered_response_to0.94350830
91MP0003186_abnormal_redox_activity0.93338105
92MP0003448_altered_tumor_morphology0.91360419
93MP0000609_abnormal_liver_physiology0.90960824
94MP0005365_abnormal_bile_salt0.90724628
95MP0005083_abnormal_biliary_tract0.90654627
96MP0000313_abnormal_cell_death0.90283364
97MP0009763_increased_sensitivity_to0.90097191
98MP0000350_abnormal_cell_proliferation0.89766668
99MP0001730_embryonic_growth_arrest0.89556833
100MP0008875_abnormal_xenobiotic_pharmacok0.89061199
101MP0008057_abnormal_DNA_replication0.89011701
102MP0000343_altered_response_to0.88740403
103MP0002933_joint_inflammation0.87938221
104MP0005384_cellular_phenotype0.84960419
105MP0003950_abnormal_plasma_membrane0.84470751
106MP0003699_abnormal_female_reproductive0.84309803
107MP0002080_prenatal_lethality0.84079763
108MP0004782_abnormal_surfactant_physiolog0.83963153
109MP0003221_abnormal_cardiomyocyte_apopto0.83243689
110MP0000015_abnormal_ear_pigmentation0.82693690
111MP0001533_abnormal_skeleton_physiology0.81975688
112MP0001929_abnormal_gametogenesis0.81922201
113MP0000598_abnormal_liver_morphology0.80682656
114MP0002210_abnormal_sex_determination0.79970934
115MP0005058_abnormal_lysosome_morphology0.77596115
116MP0005395_other_phenotype0.77182579
117MP0002132_abnormal_respiratory_system0.76549578
118MP0008932_abnormal_embryonic_tissue0.73071859
119MP0001764_abnormal_homeostasis0.72700882
120MP0003300_gastrointestinal_ulcer0.72285411
121MP0003786_premature_aging0.71082649
122MP0002653_abnormal_ependyma_morphology0.69909233
123MP0000653_abnormal_sex_gland0.68736665
124MP0003315_abnormal_perineum_morphology0.67878728
125MP0003656_abnormal_erythrocyte_physiolo0.67273281
126MP0005023_abnormal_wound_healing0.65556254
127MP0003453_abnormal_keratinocyte_physiol0.64334220

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.23597553
2Elevated erythrocyte sedimentation rate (HP:0003565)4.17643889
3Recurrent bacterial skin infections (HP:0005406)4.13412955
4Chronic otitis media (HP:0000389)3.99115566
5Myositis (HP:0100614)3.98604395
6Eczematoid dermatitis (HP:0000976)3.81967820
7Thrombocytosis (HP:0001894)3.65540882
8Abnormality of glycolipid metabolism (HP:0010969)3.58739781
9Abnormality of liposaccharide metabolism (HP:0010968)3.58739781
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.58739781
11Nasal polyposis (HP:0100582)3.56353051
12Recurrent viral infections (HP:0004429)3.51964604
13Recurrent bronchitis (HP:0002837)3.45206268
14Recurrent fungal infections (HP:0002841)3.38111565
15Abnormality of the nasal mucosa (HP:0000433)3.32584011
16Abnormality of the fingertips (HP:0001211)3.24694194
17Abnormal gallbladder physiology (HP:0012438)3.22475984
18Cholecystitis (HP:0001082)3.22475984
19Increased IgM level (HP:0003496)3.22079788
20Autoimmune thrombocytopenia (HP:0001973)3.21401216
21Aplastic anemia (HP:0001915)3.19901300
22Combined immunodeficiency (HP:0005387)3.15237743
23Abnormality of T cells (HP:0002843)3.15074367
24IgM deficiency (HP:0002850)3.10333436
25Abnormality of T cell number (HP:0011839)3.10041450
26Recurrent gram-negative bacterial infections (HP:0005420)3.03439644
27Vacuolated lymphocytes (HP:0001922)3.02438935
28Recurrent skin infections (HP:0001581)3.01688951
29T lymphocytopenia (HP:0005403)3.00246706
30Orchitis (HP:0100796)2.97288001
31Microvesicular hepatic steatosis (HP:0001414)2.95886245
32Abnormality of T cell physiology (HP:0011840)2.94968372
33IgG deficiency (HP:0004315)2.93405346
34Reduced antithrombin III activity (HP:0001976)2.87429208
35Severe combined immunodeficiency (HP:0004430)2.83996232
36Optic neuritis (HP:0100653)2.83441444
37Retrobulbar optic neuritis (HP:0100654)2.83441444
38Abnormality of macrophages (HP:0004311)2.77356388
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.76234990
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.76234990
41Ragged-red muscle fibers (HP:0003200)2.75303836
42Type I transferrin isoform profile (HP:0003642)2.72539793
43Loss of speech (HP:0002371)2.72517237
44Increased cerebral lipofuscin (HP:0011813)2.71179107
45Recurrent cutaneous fungal infections (HP:0011370)2.70160629
46Chronic mucocutaneous candidiasis (HP:0002728)2.70160629
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.68131380
48Mediastinal lymphadenopathy (HP:0100721)2.65754868
49Stomatitis (HP:0010280)2.62365456
50Hypokinesia (HP:0002375)2.61914660
51Increased serum ferritin (HP:0003281)2.58893834
52Pustule (HP:0200039)2.56149605
53Rough bone trabeculation (HP:0100670)2.55083274
54Panhypogammaglobulinemia (HP:0003139)2.54772799
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.49521724
56Interstitial pulmonary disease (HP:0006530)2.49256830
57Oral leukoplakia (HP:0002745)2.46849544
58Abnormality of the anterior horn cell (HP:0006802)2.40104151
59Degeneration of anterior horn cells (HP:0002398)2.40104151
60Male infertility (HP:0003251)2.39581796
61Autoimmune hemolytic anemia (HP:0001890)2.39272701
62Joint swelling (HP:0001386)2.39041882
63Increased intramyocellular lipid droplets (HP:0012240)2.38911222
64Abnormality of glycolysis (HP:0004366)2.36796783
65Dysostosis multiplex (HP:0000943)2.36618971
66Increased serum pyruvate (HP:0003542)2.36029597
67Leukocytosis (HP:0001974)2.35100719
68Pulmonary fibrosis (HP:0002206)2.34892105
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33554071
70Abnormal protein N-linked glycosylation (HP:0012347)2.33554071
71Abnormal protein glycosylation (HP:0012346)2.33554071
72Abnormal glycosylation (HP:0012345)2.33554071
73Lymphopenia (HP:0001888)2.32153446
74Entropion (HP:0000621)2.31986331
75Abnormality of cells of the lymphoid lineage (HP:0012140)2.31258715
76Progressive muscle weakness (HP:0003323)2.31248232
77Vasculitis (HP:0002633)2.30637437
78Increased muscle lipid content (HP:0009058)2.30073685
79Systemic lupus erythematosus (HP:0002725)2.26751068
80Hyperammonemia (HP:0001987)2.25584657
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25060714
82Abnormal trabecular bone morphology (HP:0100671)2.24970305
83Prolonged neonatal jaundice (HP:0006579)2.24779860
84Vertebral compression fractures (HP:0002953)2.24697537
85Meningitis (HP:0001287)2.23819480
86Agnosia (HP:0010524)2.22465117
87Bronchitis (HP:0012387)2.22415481
88Poikiloderma (HP:0001029)2.21680559
89Hypergammaglobulinemia (HP:0010702)2.21552148
90Petechiae (HP:0000967)2.20797642
91Progressive external ophthalmoplegia (HP:0000590)2.19903263
92Birth length less than 3rd percentile (HP:0003561)2.19793903
93Progressive neurologic deterioration (HP:0002344)2.18779457
94Premature ovarian failure (HP:0008209)2.16645798
95Granulocytopenia (HP:0001913)2.15237805
96Spontaneous hematomas (HP:0007420)2.14400828
97Abnormality of eosinophils (HP:0001879)2.13222386
98Thyroiditis (HP:0100646)2.12901633
99Gastrointestinal infarctions (HP:0005244)2.11915899
100Pulmonary infiltrates (HP:0002113)2.11770273
101Pancytopenia (HP:0001876)2.11077054
102Microretrognathia (HP:0000308)2.10976320
103Cortical dysplasia (HP:0002539)2.10112485
104Encephalitis (HP:0002383)2.06153911
105Lymphoma (HP:0002665)2.06059914
106Cellulitis (HP:0100658)2.05095495
107Eosinophilia (HP:0001880)2.04400914
108Gastrointestinal inflammation (HP:0004386)2.03783856
109Nausea (HP:0002018)2.02710733
110Amaurosis fugax (HP:0100576)2.01649682
111Agammaglobulinemia (HP:0004432)2.01140614
112Muscle fiber atrophy (HP:0100295)2.00811402
113Hepatocellular necrosis (HP:0001404)2.00111118
114Arterial thrombosis (HP:0004420)1.98931453
115Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98302197
116Abnormality of polysaccharide metabolism (HP:0011012)1.98302197
117Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98302197
118Abnormality of iron homeostasis (HP:0011031)1.98292410
119Chronic diarrhea (HP:0002028)1.97785084
120Inflammation of the large intestine (HP:0002037)1.96986938
121Abnormality of monocarboxylic acid metabolism (HP:0010996)1.96812622
122Seborrheic dermatitis (HP:0001051)1.96780526
123Hepatic necrosis (HP:0002605)1.94844320
124Impaired platelet aggregation (HP:0003540)1.94834531
125Abnormal platelet function (HP:0011869)1.94834531
126Testicular atrophy (HP:0000029)1.93711572
127Hemoptysis (HP:0002105)1.93680475
128Increased serum lactate (HP:0002151)1.93001363
129Cholelithiasis (HP:0001081)1.91901582
130Gingival bleeding (HP:0000225)1.91816326
131Colitis (HP:0002583)1.90994075
132Acute myeloid leukemia (HP:0004808)1.90865259
133Obstructive lung disease (HP:0006536)1.90692120
134Chronic obstructive pulmonary disease (HP:0006510)1.90692120
135Keratoconjunctivitis sicca (HP:0001097)1.90627388
136IgA deficiency (HP:0002720)1.90448363
137J-shaped sella turcica (HP:0002680)1.90350935
138Epistaxis (HP:0000421)1.88747465
139Chronic sinusitis (HP:0011109)1.87690497
140Type 2 muscle fiber atrophy (HP:0003554)1.86645644
141Gingivitis (HP:0000230)1.85486673
142Retinal atrophy (HP:0001105)1.84262876
143Hypertensive crisis (HP:0100735)1.84231207
144Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84043899
145Dicarboxylic aciduria (HP:0003215)1.84043899
146Fasciculations (HP:0002380)1.83208988
147Mucopolysacchariduria (HP:0008155)1.83053444
148Urinary glycosaminoglycan excretion (HP:0003541)1.83053444
149Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82985508
150Abnormal enzyme/coenzyme activity (HP:0012379)1.81992103
151Periodontitis (HP:0000704)1.81568609
152Fatigue (HP:0012378)1.81090167
153Abnormality of the distal phalanges of the toes (HP:0010182)1.81042863
154Trismus (HP:0000211)1.80893340
155Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80877026
156Abnormal mitochondria in muscle tissue (HP:0008316)1.80215631
157Myelodysplasia (HP:0002863)1.80008404
158Keratoconjunctivitis (HP:0001096)1.79603837
159Micronodular cirrhosis (HP:0001413)1.79556866
160Abnormality of fatty-acid metabolism (HP:0004359)1.78616263
161Spastic paraparesis (HP:0002313)1.78542197
162Secondary amenorrhea (HP:0000869)1.78496746
163Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78298936
164Optic nerve coloboma (HP:0000588)1.78216242
165Abnormality of pyrimidine metabolism (HP:0004353)1.78174606
166Increased CSF lactate (HP:0002490)1.77818240
167Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77677924
168Reticulocytopenia (HP:0001896)1.77672706
169Abnormality of alkaline phosphatase activity (HP:0004379)1.76749374
170Death in infancy (HP:0001522)1.76104060
171Generalized aminoaciduria (HP:0002909)1.75239173
172Abnormality of reticulocytes (HP:0004312)1.74603585
173Hepatosplenomegaly (HP:0001433)1.74163182
174Elevated alkaline phosphatase (HP:0003155)1.72766549
175Multiple enchondromatosis (HP:0005701)1.72630035
176Basal ganglia calcification (HP:0002135)1.70946029
177Reticulocytosis (HP:0001923)1.70838759
178Neutropenia (HP:0001875)1.70575249
179Rhabdomyolysis (HP:0003201)1.69933960
180Muscle stiffness (HP:0003552)1.69014635
181Lactic acidosis (HP:0003128)1.68966826
182B lymphocytopenia (HP:0010976)1.68054154
183Prolonged partial thromboplastin time (HP:0003645)1.67774894
184Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67689632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.59755005
2TYK23.23352116
3JAK32.95422749
4KIT2.89403302
5IKBKE2.85910045
6ACVR1B2.73498981
7TBK12.59287533
8PBK2.58565925
9SCYL22.51641653
10TXK2.44281324
11FGFR42.37627280
12FLT32.35453808
13BUB12.34014861
14VRK22.22091303
15EPHA22.06852317
16TAOK32.02387367
17SMG12.00893489
18STK101.98562594
19ARAF1.93511627
20ZAP701.90106722
21STK161.80545146
22EEF2K1.79692589
23MAP3K31.78342707
24IRAK41.68982422
25NEK21.65743647
26RPS6KA41.65276781
27CDK121.62582963
28ERN11.57515711
29CDK81.52711373
30BTK1.50661022
31NLK1.45979162
32MAP3K131.45062125
33IKBKB1.43150162
34CSF1R1.41746192
35SRPK11.39839666
36TGFBR11.37040679
37CHUK1.36097947
38MAP3K141.34240984
39KDR1.32623299
40JAK11.31952927
41MAP3K61.30094567
42PRPF4B1.29081697
43ERBB41.27135290
44CDK191.25866791
45MOS1.25578654
46FGFR31.19003072
47NME21.18821468
48TESK21.13135069
49CDC71.12888648
50NEK11.11802821
51PIM11.11377267
52TAOK21.10890247
53BMPR21.10449357
54EIF2AK11.09487279
55MAPK111.06371510
56SYK1.05308331
57MAP3K81.04218033
58NME11.03571368
59LCK1.01554872
60MAPKAPK31.01475028
61ABL21.01109529
62TEC0.99892484
63KSR20.99884211
64PLK40.97340909
65NEK60.96020864
66DYRK30.93990697
67PKN20.92152131
68CDK40.91806582
69PASK0.91638545
70AURKA0.91109851
71MATK0.89843560
72EPHA30.88880094
73ITK0.88725868
74MELK0.88504867
75SIK30.86858308
76JAK20.86163321
77PDK20.85855341
78STK40.84244850
79MAP3K100.83858051
80LMTK20.83654355
81LRRK20.83560354
82BRSK10.82002728
83CLK10.81509443
84SIK10.80762363
85STK38L0.80615403
86GRK60.75788170
87PIK3CA0.74605391
88BLK0.73672004
89BCKDK0.73382333
90TLK10.72905886
91TTK0.71756810
92MAP2K30.71709152
93PLK10.70221951
94STK240.70191190
95WEE10.69778158
96MAP3K10.68465116
97MST1R0.66549160
98HCK0.65776388
99ATR0.64458180
100EIF2AK20.64370113
101AURKB0.61917718
102MAP3K120.61243597
103LYN0.60419328
104STK30.60246010
105TRIM280.60214820
106LATS10.59712443
107RAF10.59449647
108EPHB10.57104486
109TSSK60.56801196
110DYRK20.56469457
111MST40.55820741
112NEK90.55659335
113MAP3K50.54291834
114RPS6KB20.53245872
115TRIB30.53092987
116IRAK30.52758987
117TAOK10.52053872
118RIPK10.51006016
119CDK70.50824827
120BMX0.49896102
121PRKCI0.49050339
122MAP3K110.48735398
123VRK10.48584373
124BRAF0.48557628
125CCNB10.48287662
126CHEK10.48234414
127PAK40.47609205
128PAK10.47515772
129CSK0.46906242
130CHEK20.46820826
131DAPK10.46235894
132EIF2AK30.46193641
133PIM20.44817452
134CDK90.44343590
135CSNK2A10.42819062
136PDPK10.42226422
137BRSK20.42132973
138TESK10.38368389
139RPS6KA50.37790329
140MAP3K90.37358934
141MET0.37135387
142TGFBR20.35842219
143MAPKAPK20.33697611
144MARK30.32324806
145CDK60.31755653
146MYLK0.31610299

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.77826225
2DNA replication_Homo sapiens_hsa030302.58492408
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.28676778
4Base excision repair_Homo sapiens_hsa034102.24351044
5Herpes simplex infection_Homo sapiens_hsa051682.09830264
6Mismatch repair_Homo sapiens_hsa034302.04071798
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03449533
8Measles_Homo sapiens_hsa051622.01320937
9Antigen processing and presentation_Homo sapiens_hsa046121.99115029
10Leishmaniasis_Homo sapiens_hsa051401.95598721
11Proteasome_Homo sapiens_hsa030501.94909376
12Allograft rejection_Homo sapiens_hsa053301.94529752
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.92320115
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88664282
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77158654
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.76447568
17Cell cycle_Homo sapiens_hsa041101.69531884
18Homologous recombination_Homo sapiens_hsa034401.69224548
19RNA polymerase_Homo sapiens_hsa030201.64724997
20Basal transcription factors_Homo sapiens_hsa030221.58325472
21Influenza A_Homo sapiens_hsa051641.57253661
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56764216
23Graft-versus-host disease_Homo sapiens_hsa053321.54862931
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49818033
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.49416120
26Legionellosis_Homo sapiens_hsa051341.48894871
27RNA degradation_Homo sapiens_hsa030181.46570994
28Fructose and mannose metabolism_Homo sapiens_hsa000511.45967013
29Nucleotide excision repair_Homo sapiens_hsa034201.45384085
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43201866
31RNA transport_Homo sapiens_hsa030131.40597982
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39646608
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38500181
34Lysosome_Homo sapiens_hsa041421.37100944
35Carbon metabolism_Homo sapiens_hsa012001.34002709
36Pyrimidine metabolism_Homo sapiens_hsa002401.33164753
37B cell receptor signaling pathway_Homo sapiens_hsa046621.32357112
38Fatty acid elongation_Homo sapiens_hsa000621.31559457
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.28371670
40Staphylococcus aureus infection_Homo sapiens_hsa051501.27200125
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.27192303
42Shigellosis_Homo sapiens_hsa051311.25429006
43One carbon pool by folate_Homo sapiens_hsa006701.23977820
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23883265
45Osteoclast differentiation_Homo sapiens_hsa043801.19329245
46Spliceosome_Homo sapiens_hsa030401.17631224
47Hematopoietic cell lineage_Homo sapiens_hsa046401.17058263
48T cell receptor signaling pathway_Homo sapiens_hsa046601.16793196
49Apoptosis_Homo sapiens_hsa042101.14707141
50Hepatitis B_Homo sapiens_hsa051611.14636596
51Ribosome_Homo sapiens_hsa030101.13053186
52Epstein-Barr virus infection_Homo sapiens_hsa051691.12742201
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10448345
54Folate biosynthesis_Homo sapiens_hsa007901.09303462
55p53 signaling pathway_Homo sapiens_hsa041151.08970117
56Glutathione metabolism_Homo sapiens_hsa004801.07907789
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07758873
58SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07226208
59Toxoplasmosis_Homo sapiens_hsa051451.06782646
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05900070
61Pancreatic cancer_Homo sapiens_hsa052121.05345013
62N-Glycan biosynthesis_Homo sapiens_hsa005101.05085938
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04888484
64Galactose metabolism_Homo sapiens_hsa000521.04751091
65Non-homologous end-joining_Homo sapiens_hsa034501.02449889
66Malaria_Homo sapiens_hsa051441.01448094
67Viral myocarditis_Homo sapiens_hsa054160.97629252
68Selenocompound metabolism_Homo sapiens_hsa004500.95872408
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94136860
70Prolactin signaling pathway_Homo sapiens_hsa049170.91690782
71Pentose phosphate pathway_Homo sapiens_hsa000300.91317281
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91094038
73TNF signaling pathway_Homo sapiens_hsa046680.89572482
74Other glycan degradation_Homo sapiens_hsa005110.89264853
75Caffeine metabolism_Homo sapiens_hsa002320.88805593
76Acute myeloid leukemia_Homo sapiens_hsa052210.87203635
77Pertussis_Homo sapiens_hsa051330.84003520
78Hepatitis C_Homo sapiens_hsa051600.81622529
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80153393
80HTLV-I infection_Homo sapiens_hsa051660.79473888
81Tuberculosis_Homo sapiens_hsa051520.79166126
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78809111
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.76440924
84Vibrio cholerae infection_Homo sapiens_hsa051100.75628939
85Viral carcinogenesis_Homo sapiens_hsa052030.75623377
86Fanconi anemia pathway_Homo sapiens_hsa034600.75083699
87Oxidative phosphorylation_Homo sapiens_hsa001900.75055567
88Bladder cancer_Homo sapiens_hsa052190.74662246
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72821420
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72528173
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71623919
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70563429
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70542235
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.70450812
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70448605
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.67132421
97Rheumatoid arthritis_Homo sapiens_hsa053230.66271761
98Notch signaling pathway_Homo sapiens_hsa043300.65925742
99Sulfur relay system_Homo sapiens_hsa041220.65775380
100Parkinsons disease_Homo sapiens_hsa050120.64755786
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64570561
102Vitamin B6 metabolism_Homo sapiens_hsa007500.62654337
103Sulfur metabolism_Homo sapiens_hsa009200.61300287
104Chronic myeloid leukemia_Homo sapiens_hsa052200.60850475
105Chemokine signaling pathway_Homo sapiens_hsa040620.60060921
106Vitamin digestion and absorption_Homo sapiens_hsa049770.57937815
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57669443
108Asthma_Homo sapiens_hsa053100.57553245
109Colorectal cancer_Homo sapiens_hsa052100.57167521
110mRNA surveillance pathway_Homo sapiens_hsa030150.56414348
111Thyroid cancer_Homo sapiens_hsa052160.55854757
112Type I diabetes mellitus_Homo sapiens_hsa049400.55686381
113Regulation of autophagy_Homo sapiens_hsa041400.54309293
114Autoimmune thyroid disease_Homo sapiens_hsa053200.52026929
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51972028
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51365177
117Purine metabolism_Homo sapiens_hsa002300.50006436
118Huntingtons disease_Homo sapiens_hsa050160.49920394
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.49623752
120Salmonella infection_Homo sapiens_hsa051320.47814019
121Non-small cell lung cancer_Homo sapiens_hsa052230.47468679
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45426688
123Biosynthesis of amino acids_Homo sapiens_hsa012300.44473296
124Pyruvate metabolism_Homo sapiens_hsa006200.44380729
125Small cell lung cancer_Homo sapiens_hsa052220.43433388
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42771827
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40868028
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40030848
129Systemic lupus erythematosus_Homo sapiens_hsa053220.35478173
130Complement and coagulation cascades_Homo sapiens_hsa046100.33550958
131Peroxisome_Homo sapiens_hsa041460.32603258
132VEGF signaling pathway_Homo sapiens_hsa043700.31726695

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