RNF113B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic nuclear division (GO:0007126)9.79415058
2DNA methylation involved in gamete generation (GO:0043046)9.44331916
3histone H3-K9 demethylation (GO:0033169)8.40615607
4meiotic cell cycle process (GO:1903046)8.12381040
5sister chromatid cohesion (GO:0007062)7.88301059
6reciprocal meiotic recombination (GO:0007131)6.51121176
7reciprocal DNA recombination (GO:0035825)6.51121176
8regulation of meiosis I (GO:0060631)5.56323635
9resolution of meiotic recombination intermediates (GO:0000712)5.48465768
10gene silencing by RNA (GO:0031047)5.03183231
11meiotic chromosome segregation (GO:0045132)4.88136549
12histone H3-K36 demethylation (GO:0070544)4.68425337
13positive regulation of meiosis (GO:0045836)4.51408798
14mitotic metaphase plate congression (GO:0007080)4.25989945
15histone lysine demethylation (GO:0070076)4.24289282
16positive regulation of meiotic cell cycle (GO:0051446)4.22712906
17negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)4.17489697
18regulation of meiotic cell cycle (GO:0051445)4.14626672
19attachment of spindle microtubules to kinetochore (GO:0008608)4.14203814
20negative regulation of inclusion body assembly (GO:0090084)4.13017787
21histone demethylation (GO:0016577)4.11660374
22mitotic spindle assembly checkpoint (GO:0007094)3.95887903
23female gamete generation (GO:0007292)3.90528982
24positive regulation of response to oxidative stress (GO:1902884)3.89464233
25positive regulation of cellular response to oxidative stress (GO:1900409)3.89464233
26spindle assembly checkpoint (GO:0071173)3.85670168
27regulation of DNA endoreduplication (GO:0032875)3.83888284
28metaphase plate congression (GO:0051310)3.77023269
29DNA alkylation (GO:0006305)3.75734788
30DNA methylation (GO:0006306)3.75734788
31protein dealkylation (GO:0008214)3.75298678
32protein demethylation (GO:0006482)3.75298678
33acrosome reaction (GO:0007340)3.74197113
34proteasome assembly (GO:0043248)3.71974520
35protein localization to chromosome (GO:0034502)3.71686608
36genitalia morphogenesis (GO:0035112)3.69463300
37outer ear morphogenesis (GO:0042473)3.68464042
38mitotic spindle checkpoint (GO:0071174)3.66429317
39negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.66372118
40negative regulation of mitotic sister chromatid segregation (GO:0033048)3.66372118
41negative regulation of mitotic sister chromatid separation (GO:2000816)3.66372118
42negative regulation of sister chromatid segregation (GO:0033046)3.66372118
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.66372118
44histone H2A acetylation (GO:0043968)3.62702529
45chromosome organization (GO:0051276)3.60476013
46negative regulation of chromosome segregation (GO:0051985)3.56321694
47mitotic sister chromatid cohesion (GO:0007064)3.47365939
48spindle checkpoint (GO:0031577)3.41935878
49spermatid development (GO:0007286)3.39450671
50fertilization (GO:0009566)3.37729173
51negative regulation of smooth muscle cell differentiation (GO:0051151)3.33538226
52DNA biosynthetic process (GO:0071897)3.29478323
53regulation of histone H3-K9 methylation (GO:0051570)3.28861889
54regulation of mitotic sister chromatid separation (GO:0010965)3.24588296
55regulation of mitotic sister chromatid segregation (GO:0033047)3.24588296
56regulation of sister chromatid segregation (GO:0033045)3.24588296
57meiotic cell cycle (GO:0051321)3.22708264
58interkinetic nuclear migration (GO:0022027)3.18967242
59macroautophagy (GO:0016236)3.17508787
60binding of sperm to zona pellucida (GO:0007339)3.13369491
61oogenesis (GO:0048477)3.11760880
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11295905
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11295905
64regulation of meiosis (GO:0040020)3.08953771
65histone exchange (GO:0043486)3.08723838
66negative regulation of meiosis (GO:0045835)3.04452212
67negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.00938533
68DNA methylation or demethylation (GO:0044728)2.96099046
69gene silencing (GO:0016458)2.95097831
70nuclear division (GO:0000280)2.94736477
71negative regulation of DNA repair (GO:0045738)2.92718015
72negative regulation of nuclear division (GO:0051784)2.85816014
73germ cell development (GO:0007281)2.85183028
74establishment of protein localization to Golgi (GO:0072600)2.81445598
75response to pheromone (GO:0019236)2.80666305
76protein targeting to Golgi (GO:0000042)2.75593091
77negative regulation of mitosis (GO:0045839)2.73906854
78oocyte maturation (GO:0001556)2.72291585
79organelle fission (GO:0048285)2.70572318
80mitotic chromosome condensation (GO:0007076)2.69598757
81histone H4-K12 acetylation (GO:0043983)2.68794872
82regulation of chromosome segregation (GO:0051983)2.63180962
83reproductive system development (GO:0061458)2.60486520
84regulation of mitotic spindle organization (GO:0060236)2.58866808
85establishment of chromosome localization (GO:0051303)2.56176022
86regulation of protein polyubiquitination (GO:1902914)2.55684726
87DNA modification (GO:0006304)2.53251391
88DNA packaging (GO:0006323)2.52264137
89SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.52182187
90sperm-egg recognition (GO:0035036)2.50641159
91cellular process involved in reproduction in multicellular organism (GO:0022412)2.49849107
92synapsis (GO:0007129)15.6212405
93chromosome organization involved in meiosis (GO:0070192)14.4650703
94synaptonemal complex assembly (GO:0007130)13.6246524
95male meiosis I (GO:0007141)13.2163366
96synaptonemal complex organization (GO:0070193)12.5359548
97piRNA metabolic process (GO:0034587)12.1997873
98male meiosis (GO:0007140)10.9014971
99meiosis I (GO:0007127)10.6597085
100DNA synthesis involved in DNA repair (GO:0000731)10.5089741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.64954505
2IGF1R_20145208_ChIP-Seq_DFB_Human3.90219743
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.28611063
4RNF2_27304074_Chip-Seq_NSC_Mouse3.20968009
5BMI1_23680149_ChIP-Seq_NPCS_Mouse2.89219575
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.76123552
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61250543
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.54420862
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53897322
10FUS_26573619_Chip-Seq_HEK293_Human2.51915333
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51724652
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38904025
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32351468
14ZNF274_21170338_ChIP-Seq_K562_Hela2.23067960
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.22518530
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.22376563
17ER_23166858_ChIP-Seq_MCF-7_Human2.16592773
18BCAT_22108803_ChIP-Seq_LS180_Human2.03528120
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02986453
20EWS_26573619_Chip-Seq_HEK293_Human1.99457416
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.92057055
22P300_19829295_ChIP-Seq_ESCs_Human1.91258291
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89551621
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.87274957
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77714169
26STAT3_23295773_ChIP-Seq_U87_Human1.75482293
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74528840
28SMAD4_21741376_ChIP-Seq_EPCs_Human1.68587016
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67593842
30* RUNX2_22187159_ChIP-Seq_PCA_Human1.64399605
31AR_25329375_ChIP-Seq_VCAP_Human1.56655582
32FOXA1_21572438_ChIP-Seq_LNCaP_Human1.55200010
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55098773
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54938084
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52428723
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51739581
37TAF15_26573619_Chip-Seq_HEK293_Human1.49973874
38TCF4_23295773_ChIP-Seq_U87_Human1.46366830
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46089549
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44837681
41* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43918690
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43315212
43VDR_22108803_ChIP-Seq_LS180_Human1.41448107
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40326129
45* PRDM14_20953172_ChIP-Seq_ESCs_Human1.38178357
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37021198
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35722174
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34071223
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33940078
50TCF4_22108803_ChIP-Seq_LS180_Human1.32756393
51SMAD4_21799915_ChIP-Seq_A2780_Human1.31273256
52IRF1_19129219_ChIP-ChIP_H3396_Human1.28989007
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.27563639
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25952002
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25912348
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25912348
57FLI1_21867929_ChIP-Seq_TH2_Mouse1.25101145
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24570491
59PHF8_20622853_ChIP-Seq_HELA_Human1.24170145
60AR_21572438_ChIP-Seq_LNCaP_Human1.23495007
61CDX2_22108803_ChIP-Seq_LS180_Human1.22735485
62GATA3_26560356_Chip-Seq_TH1_Human1.21804256
63* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.21776346
64TP63_23658742_ChIP-Seq_EP156T_Human1.19704715
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19644585
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19580055
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19009982
68CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14973165
69* TBL1_22424771_ChIP-Seq_293T_Human1.14911021
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.13855309
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.13258335
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.12676854
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12534568
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.10814381
75RXR_22108803_ChIP-Seq_LS180_Human1.10319328
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10170972
77CBP_21632823_ChIP-Seq_H3396_Human1.09690177
78CBP_20019798_ChIP-Seq_JUKART_Human1.09652393
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09652393
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.08549673
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08414816
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.06510297
83NFYB_21822215_ChIP-Seq_K562_Human1.06455361
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05785942
85SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.04909954
86ETV1_20927104_ChIP-Seq_GIST48_Human1.04136637
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03609284
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03531504
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02990699
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.02990699
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02236222
92MYC_18940864_ChIP-ChIP_HL60_Human1.00487980
93TP53_22573176_ChIP-Seq_HFKS_Human0.98724015
94HOXB7_26014856_ChIP-Seq_BT474_Human0.98596894
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97812207
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95906522
97AR_20517297_ChIP-Seq_VCAP_Human0.93561103
98RBPJ_21746931_ChIP-Seq_IB4_Human0.93474239
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93451866
100* BRD4_25478319_ChIP-Seq_HGPS_Human0.93443895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.86459347
2MP0000569_abnormal_digit_pigmentation6.64040572
3MP0002210_abnormal_sex_determination4.75761353
4MP0008058_abnormal_DNA_repair4.63153927
5MP0001929_abnormal_gametogenesis4.27030661
6MP0001145_abnormal_male_reproductive3.54935018
7MP0003698_abnormal_male_reproductive3.50620251
8MP0000653_abnormal_sex_gland3.39796094
9MP0002160_abnormal_reproductive_system3.35372356
10MP0005174_abnormal_tail_pigmentation2.82846830
11MP0000015_abnormal_ear_pigmentation2.46410415
12MP0001119_abnormal_female_reproductive2.39393079
13MP0000678_abnormal_parathyroid_gland2.35442376
14MP0005410_abnormal_fertilization2.25211545
15MP0003693_abnormal_embryo_hatching2.19268277
16MP0003136_yellow_coat_color2.07164212
17MP0005389_reproductive_system_phenotype2.01964032
18MP0003699_abnormal_female_reproductive2.00646507
19MP0002161_abnormal_fertility/fecundity1.95607372
20MP0008995_early_reproductive_senescence1.80606724
21MP0002095_abnormal_skin_pigmentation1.63672951
22MP0003718_maternal_effect1.61243353
23MP0008004_abnormal_stomach_pH1.59263041
24MP0008057_abnormal_DNA_replication1.52614454
25MP0010094_abnormal_chromosome_stability1.46727906
26MP0000427_abnormal_hair_cycle1.34985790
27MP0009046_muscle_twitch1.31224993
28MP0004381_abnormal_hair_follicle1.29010073
29MP0008007_abnormal_cellular_replicative1.23384761
30MP0010307_abnormal_tumor_latency1.15489465
31MP0000383_abnormal_hair_follicle1.14425992
32MP0000372_irregular_coat_pigmentation1.09888787
33MP0003646_muscle_fatigue1.09045303
34MP0003950_abnormal_plasma_membrane1.07772582
35MP0003786_premature_aging1.07325841
36MP0003077_abnormal_cell_cycle1.06980215
37MP0001664_abnormal_digestion1.05814107
38MP0002638_abnormal_pupillary_reflex1.05690882
39MP0006276_abnormal_autonomic_nervous1.04119880
40MP0003011_delayed_dark_adaptation1.00938380
41MP0003111_abnormal_nucleus_morphology0.99978698
42MP0008260_abnormal_autophagy0.96070082
43MP0004808_abnormal_hematopoietic_stem0.95065365
44MP0005058_abnormal_lysosome_morphology0.93973667
45MP0003936_abnormal_reproductive_system0.93475378
46MP0001485_abnormal_pinna_reflex0.88133212
47MP0005395_other_phenotype0.87566020
48MP0005171_absent_coat_pigmentation0.85958746
49MP0003943_abnormal_hepatobiliary_system0.85777097
50MP0005310_abnormal_salivary_gland0.81509787
51MP0001501_abnormal_sleep_pattern0.79848347
52MP0002067_abnormal_sensory_capabilities0.78199017
53MP0000685_abnormal_immune_system0.77442040
54MP0002282_abnormal_trachea_morphology0.76819924
55MP0002249_abnormal_larynx_morphology0.75797573
56MP0003045_fibrosis0.75073997
57MP0002229_neurodegeneration0.74168970
58MP0003937_abnormal_limbs/digits/tail_de0.72179466
59MP0003567_abnormal_fetal_cardiomyocyte0.72117977
60MP0005253_abnormal_eye_physiology0.71332729
61MP0010030_abnormal_orbit_morphology0.68965184
62MP0001502_abnormal_circadian_rhythm0.68040827
63MP0005551_abnormal_eye_electrophysiolog0.67534998
64MP0008789_abnormal_olfactory_epithelium0.67282004
65MP0010678_abnormal_skin_adnexa0.66934385
66MP0002277_abnormal_respiratory_mucosa0.65968052
67MP0000049_abnormal_middle_ear0.65311243
68MP0005076_abnormal_cell_differentiation0.65053853
69MP0000371_diluted_coat_color0.63669852
70MP0009250_abnormal_appendicular_skeleto0.63658501
71MP0000566_synostosis0.62079261
72MP0004043_abnormal_pH_regulation0.60858424
73MP0006072_abnormal_retinal_apoptosis0.58891625
74MP0005397_hematopoietic_system_phenotyp0.57886323
75MP0001545_abnormal_hematopoietic_system0.57886323
76MP0003329_amyloid_beta_deposits0.57616098
77MP0002177_abnormal_outer_ear0.54726967
78MP0000631_abnormal_neuroendocrine_gland0.53275894
79MP0002108_abnormal_muscle_morphology0.52600228
80MP0004019_abnormal_vitamin_homeostasis0.52454414
81MP0001730_embryonic_growth_arrest0.51125655
82MP0009703_decreased_birth_body0.50942308
83MP0003938_abnormal_ear_development0.50830886
84MP0006036_abnormal_mitochondrial_physio0.50180777
85MP0002269_muscular_atrophy0.49296642
86MP0002114_abnormal_axial_skeleton0.47896112
87MP0003195_calcinosis0.47774790
88MP0002971_abnormal_brown_adipose0.47303706
89MP0001963_abnormal_hearing_physiology0.44668532
90MP0001324_abnormal_eye_pigmentation0.42664140
91MP0000470_abnormal_stomach_morphology0.42600153
92MP0003879_abnormal_hair_cell0.42334662
93MP0000516_abnormal_urinary_system0.41951238
94MP0005367_renal/urinary_system_phenotyp0.41951238
95MP0002168_other_aberrant_phenotype0.41449086
96MP0000432_abnormal_head_morphology0.39432409
97MP0002116_abnormal_craniofacial_bone0.37084757
98MP0000778_abnormal_nervous_system0.36930633
99MP0000647_abnormal_sebaceous_gland0.36114931
100MP0005647_abnormal_sex_gland0.35611802

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous abortion (HP:0005268)6.41707268
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.58634015
3Chromsome breakage (HP:0040012)5.44930161
4Oligodactyly (hands) (HP:0001180)5.33301095
5Volvulus (HP:0002580)4.88590068
6Azoospermia (HP:0000027)4.70098431
7Ectopic kidney (HP:0000086)4.61133533
8Duplicated collecting system (HP:0000081)4.57493110
9Abnormality of the renal collecting system (HP:0004742)4.32160910
10Gonadotropin excess (HP:0000837)4.28866504
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.01996486
12Degeneration of the lateral corticospinal tracts (HP:0002314)4.01996486
13Abnormal spermatogenesis (HP:0008669)3.98909927
14Abnormality of DNA repair (HP:0003254)3.98250269
15Nephronophthisis (HP:0000090)3.79786740
16Small intestinal stenosis (HP:0012848)3.55629190
17Duodenal stenosis (HP:0100867)3.55629190
18Abnormality of the renal medulla (HP:0100957)3.49391978
19Abnormality of midbrain morphology (HP:0002418)3.44211757
20Molar tooth sign on MRI (HP:0002419)3.44211757
21Tubulointerstitial nephritis (HP:0001970)3.41859760
22Reticulocytopenia (HP:0001896)3.41418952
23Abnormality of pyrimidine metabolism (HP:0004353)3.37853565
24Oligodactyly (HP:0012165)3.32729622
25Abnormality of chromosome stability (HP:0003220)3.29355856
26Clubbing of toes (HP:0100760)3.26263764
27Aplasia/Hypoplasia of the uvula (HP:0010293)3.19436200
28Truncal obesity (HP:0001956)3.19314048
29Facial hemangioma (HP:0000329)2.94179022
30Increased nuchal translucency (HP:0010880)2.92101694
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.90572343
32Abnormality of the duodenum (HP:0002246)2.90021929
33Abnormal biliary tract physiology (HP:0012439)2.84506768
34Bile duct proliferation (HP:0001408)2.84506768
35Vacuolated lymphocytes (HP:0001922)2.83294372
36Abnormality of the ileum (HP:0001549)2.82665443
37Meckel diverticulum (HP:0002245)2.82386487
38Embryonal renal neoplasm (HP:0011794)2.81944658
39Absent radius (HP:0003974)2.77014151
40Abnormality of the preputium (HP:0100587)2.70274123
41Aplasia/Hypoplasia of the sternum (HP:0006714)2.67326497
42Abnormality of the corticospinal tract (HP:0002492)2.66024604
4311 pairs of ribs (HP:0000878)2.65896064
44Nephroblastoma (Wilms tumor) (HP:0002667)2.63170095
45Absent forearm bone (HP:0003953)2.59486912
46Aplasia involving forearm bones (HP:0009822)2.59486912
47Abnormal lung lobation (HP:0002101)2.58456245
48Bifid tongue (HP:0010297)2.56270570
49True hermaphroditism (HP:0010459)2.55020659
50Pancreatic fibrosis (HP:0100732)2.50437238
51Optic nerve coloboma (HP:0000588)2.48359491
52Duplication of thumb phalanx (HP:0009942)2.44840280
53Myelodysplasia (HP:0002863)2.42167204
54Congenital stationary night blindness (HP:0007642)2.41433680
55Generalized hypopigmentation of hair (HP:0011358)2.40926049
56Supernumerary spleens (HP:0009799)2.37546682
57Absent thumb (HP:0009777)2.36760893
58Scotoma (HP:0000575)2.33818292
59Cystic liver disease (HP:0006706)2.31255211
60Shoulder girdle muscle weakness (HP:0003547)2.30729262
61Pancreatic cysts (HP:0001737)2.28589516
62Hypoplastic labia majora (HP:0000059)2.20101994
63Fair hair (HP:0002286)2.17520893
64Wrist flexion contracture (HP:0001239)2.17153966
65Widely spaced teeth (HP:0000687)2.13048422
66Lip pit (HP:0100267)2.10193619
67Sloping forehead (HP:0000340)2.10165973
68Ureteral duplication (HP:0000073)2.07598904
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.06973568
70Resting tremor (HP:0002322)2.05290117
71Hypoplastic iliac wings (HP:0002866)2.03933457
72Abnormality of the labia majora (HP:0012881)2.01870725
73Abnormality of chromosome segregation (HP:0002916)2.00733621
74Impaired vibration sensation in the lower limbs (HP:0002166)2.00469848
75Neurofibrillary tangles (HP:0002185)1.96328942
76Febrile seizures (HP:0002373)1.95419465
77Abnormality of the labia minora (HP:0012880)1.94996908
78Bell-shaped thorax (HP:0001591)1.93627536
79Severe visual impairment (HP:0001141)1.92283476
80Horseshoe kidney (HP:0000085)1.90497325
81Loss of speech (HP:0002371)1.89755211
82Capillary hemangiomas (HP:0005306)1.86251733
83Multicystic kidney dysplasia (HP:0000003)1.85846148
84Abnormality of the labia (HP:0000058)1.85560419
85Follicular hyperkeratosis (HP:0007502)1.81688986
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78173836
87Abnormality of alanine metabolism (HP:0010916)1.78173836
88Hyperalaninemia (HP:0003348)1.78173836
89Rimmed vacuoles (HP:0003805)1.77763098
90Preaxial hand polydactyly (HP:0001177)1.75994900
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.75606964
92Abnormality of the carotid arteries (HP:0005344)1.73352556
93Astigmatism (HP:0000483)1.72183988
94Short thumb (HP:0009778)1.71836153
95Cafe-au-lait spot (HP:0000957)1.70008927
96Broad distal phalanx of finger (HP:0009836)1.69051645
97Bradykinesia (HP:0002067)1.63604894
98Tubulointerstitial abnormality (HP:0001969)1.63406256
99Impaired smooth pursuit (HP:0007772)1.62593092
100Abnormality of the renal cortex (HP:0011035)1.61627275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.34321053
2PNCK4.25041706
3CDK193.45353387
4GRK13.44345905
5STK38L2.99644804
6PLK42.90380897
7STK382.83343432
8ACVR1B2.49651788
9FRK2.30208758
10TTK2.28992962
11BUB12.25206357
12ADRBK22.11554360
13OXSR12.05471870
14STK162.03133781
15BMPR1B1.97880917
16PTK2B1.95169198
17FGFR31.89107755
18AKT31.82438489
19MARK31.68782196
20WEE11.62730580
21PLK11.62079928
22MET1.59273051
23LATS11.57197472
24BRSK21.51696449
25MAP3K21.50783113
26PLK21.43314643
27MAP3K41.32031026
28MAP3K31.25465474
29ZAK1.17800884
30DYRK1A1.17796824
31KSR11.14561741
32PBK1.13980861
33NEK91.11121794
34MST1R1.11050870
35NEK20.97262586
36BRAF0.97238935
37MAP3K130.97000814
38VRK10.95584337
39PINK10.95514751
40KSR20.94151670
41ADRBK10.88000178
42NLK0.87724942
43TAOK10.87378506
44MAPK130.87203125
45WNK30.86088803
46NTRK30.85572253
47RAF10.84404217
48ATM0.83932370
49NUAK10.82129772
50FGR0.80564872
51MAP2K30.79378145
52CHEK10.78167230
53RET0.78036287
54ATR0.74106600
55IKBKE0.72976605
56STK30.72325152
57MAP3K10.72086025
58IRAK10.69420721
59SGK10.69217857
60WNK10.67751519
61CDK120.67357241
62CDK30.65855556
63RPS6KB10.64130154
64PRKCI0.60042405
65SGK20.58733288
66MELK0.58502747
67EGFR0.56944377
68INSRR0.54638804
69PLK30.54139795
70BMX0.53664042
71AURKA0.52831113
72MAP3K50.49150927
73PDK10.48017252
74FGFR10.47903419
75PRKACB0.47122833
76CHEK20.46622712
77AKT20.45072950
78EIF2AK30.44801135
79TAOK30.43077748
80DDR20.42998721
81PDGFRB0.39112882
82CAMK1G0.38248204
83STK110.36879882
84STK390.34724904
85TLK10.34682760
86MAPK70.34483811
87MAPK10.34127754
88PRKD20.33962109
89PRKCQ0.32384172
90CDK10.31800418
91PRKG10.30685686
92IGF1R0.30450274
93CCNB10.30248415
94MAP2K10.30035083
95PRKD10.29694862
96STK100.29102605
97JAK30.28249547
98PIK3CA0.27992445
99TBK10.27441792
100PDPK10.27316900

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034404.84138617
2Non-homologous end-joining_Homo sapiens_hsa034504.27740971
3Oocyte meiosis_Homo sapiens_hsa041143.46148947
4Fanconi anemia pathway_Homo sapiens_hsa034603.32072150
5Progesterone-mediated oocyte maturation_Homo sapiens_hsa049143.27366941
6Cell cycle_Homo sapiens_hsa041103.12634259
7Dorso-ventral axis formation_Homo sapiens_hsa043203.00142203
8Sulfur relay system_Homo sapiens_hsa041222.87180210
9Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.32004891
10Nitrogen metabolism_Homo sapiens_hsa009102.14984404
11Circadian rhythm_Homo sapiens_hsa047102.14056673
12RNA transport_Homo sapiens_hsa030131.93231483
13RNA degradation_Homo sapiens_hsa030181.92152239
14Propanoate metabolism_Homo sapiens_hsa006401.91602544
15Lysine degradation_Homo sapiens_hsa003101.85492090
16beta-Alanine metabolism_Homo sapiens_hsa004101.68251861
17Base excision repair_Homo sapiens_hsa034101.67658878
18Other glycan degradation_Homo sapiens_hsa005111.66080791
19Basal transcription factors_Homo sapiens_hsa030221.58167732
20Mismatch repair_Homo sapiens_hsa034301.56318442
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55835015
22mRNA surveillance pathway_Homo sapiens_hsa030151.47321088
23Phototransduction_Homo sapiens_hsa047441.44939748
24Olfactory transduction_Homo sapiens_hsa047401.32605580
25Butanoate metabolism_Homo sapiens_hsa006501.31639650
26Retinol metabolism_Homo sapiens_hsa008301.15449072
27Taste transduction_Homo sapiens_hsa047421.05796471
28Regulation of autophagy_Homo sapiens_hsa041401.04225193
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02833429
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01773550
31Linoleic acid metabolism_Homo sapiens_hsa005910.99934780
32p53 signaling pathway_Homo sapiens_hsa041150.99670949
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96603371
34mTOR signaling pathway_Homo sapiens_hsa041500.96370292
35Legionellosis_Homo sapiens_hsa051340.95033238
36Calcium signaling pathway_Homo sapiens_hsa040200.93591462
37NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91215523
38Hedgehog signaling pathway_Homo sapiens_hsa043400.90974752
39DNA replication_Homo sapiens_hsa030300.90827208
40Vitamin B6 metabolism_Homo sapiens_hsa007500.89975098
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82281557
42Glycerolipid metabolism_Homo sapiens_hsa005610.79744166
43Inositol phosphate metabolism_Homo sapiens_hsa005620.78131351
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78100895
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75736624
46Tryptophan metabolism_Homo sapiens_hsa003800.74612867
47Nucleotide excision repair_Homo sapiens_hsa034200.73817363
48TGF-beta signaling pathway_Homo sapiens_hsa043500.72980026
49Arachidonic acid metabolism_Homo sapiens_hsa005900.70290609
50Fatty acid biosynthesis_Homo sapiens_hsa000610.68607129
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65408358
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.63741127
53FoxO signaling pathway_Homo sapiens_hsa040680.63676998
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62907880
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60019263
56Serotonergic synapse_Homo sapiens_hsa047260.58837159
57ABC transporters_Homo sapiens_hsa020100.57545982
58Pyruvate metabolism_Homo sapiens_hsa006200.54191298
59Glucagon signaling pathway_Homo sapiens_hsa049220.52468593
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.46517389
61HTLV-I infection_Homo sapiens_hsa051660.46206995
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.46136161
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44996340
64Type II diabetes mellitus_Homo sapiens_hsa049300.44062420
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.43808141
66Bile secretion_Homo sapiens_hsa049760.42801497
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42525131
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40997932
69Ovarian steroidogenesis_Homo sapiens_hsa049130.37504217
70Phenylalanine metabolism_Homo sapiens_hsa003600.37456932
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37243204
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37089272
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35891801
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34421875
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33668804
76MAPK signaling pathway_Homo sapiens_hsa040100.33464538
77Ether lipid metabolism_Homo sapiens_hsa005650.33035313
78Choline metabolism in cancer_Homo sapiens_hsa052310.32943443
79Prostate cancer_Homo sapiens_hsa052150.32293998
80Mineral absorption_Homo sapiens_hsa049780.30861863
81TNF signaling pathway_Homo sapiens_hsa046680.30376153
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.30028571
83Peroxisome_Homo sapiens_hsa041460.29957609
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26624926
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26175570
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24854086
87Selenocompound metabolism_Homo sapiens_hsa004500.24533975
88Fatty acid degradation_Homo sapiens_hsa000710.24411190
89Gap junction_Homo sapiens_hsa045400.23779394
90ErbB signaling pathway_Homo sapiens_hsa040120.23540221
91Histidine metabolism_Homo sapiens_hsa003400.23036864
92Cholinergic synapse_Homo sapiens_hsa047250.22435167
93Platelet activation_Homo sapiens_hsa046110.21965373
94Apoptosis_Homo sapiens_hsa042100.19844249
95Chemical carcinogenesis_Homo sapiens_hsa052040.19594775
96GnRH signaling pathway_Homo sapiens_hsa049120.19231271
97Hepatitis C_Homo sapiens_hsa051600.17810490
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17027031
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16950887
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.16035475

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