RNASEH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter isoform. This gene has three pseudogenes; two of them are at different locations of chromosome 17 and one of them is on chromosome 1q32.2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.16204042
2DNA strand elongation involved in DNA replication (GO:0006271)4.65410762
3DNA strand elongation (GO:0022616)4.44983880
4DNA replication initiation (GO:0006270)4.35990293
5telomere maintenance via semi-conservative replication (GO:0032201)4.32223448
6pseudouridine synthesis (GO:0001522)4.21483000
7nucleobase biosynthetic process (GO:0046112)4.17561016
8DNA replication checkpoint (GO:0000076)4.04090660
9establishment of integrated proviral latency (GO:0075713)4.01041478
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.99892777
11ribosome biogenesis (GO:0042254)3.98221362
12ribosomal small subunit assembly (GO:0000028)3.93980710
13chaperone-mediated protein transport (GO:0072321)3.93374624
14purine nucleobase biosynthetic process (GO:0009113)3.92220031
15mitotic metaphase plate congression (GO:0007080)3.87643320
16formation of translation preinitiation complex (GO:0001731)3.84660291
17telomere maintenance via recombination (GO:0000722)3.81963784
18maturation of SSU-rRNA (GO:0030490)3.77594549
19cullin deneddylation (GO:0010388)3.75692616
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.73128849
21protein localization to kinetochore (GO:0034501)3.72794246
22histone exchange (GO:0043486)3.70871918
23termination of RNA polymerase III transcription (GO:0006386)3.70295217
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.70295217
25ribosome assembly (GO:0042255)3.62063600
26ribonucleoprotein complex biogenesis (GO:0022613)3.61934355
27IMP biosynthetic process (GO:0006188)3.52706352
28DNA unwinding involved in DNA replication (GO:0006268)3.51682504
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49988392
30protein deneddylation (GO:0000338)3.49874223
31IMP metabolic process (GO:0046040)3.49431303
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49316109
33CENP-A containing nucleosome assembly (GO:0034080)3.48274743
34telomere maintenance via telomere lengthening (GO:0010833)3.48120283
35rRNA methylation (GO:0031167)3.47188660
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45080810
37maturation of 5.8S rRNA (GO:0000460)3.44898251
38proteasome assembly (GO:0043248)3.43119442
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.42484373
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42484373
41mitotic recombination (GO:0006312)3.41706898
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39546365
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39241411
44regulation of mitochondrial translation (GO:0070129)3.36413354
45L-serine metabolic process (GO:0006563)3.32332118
46protein targeting to mitochondrion (GO:0006626)3.32110421
47spliceosomal snRNP assembly (GO:0000387)3.31256787
48viral transcription (GO:0019083)3.30656087
49rRNA processing (GO:0006364)3.30427974
50chromatin remodeling at centromere (GO:0031055)3.29217115
51regulation of cellular amino acid metabolic process (GO:0006521)3.28240761
52metaphase plate congression (GO:0051310)3.27484932
53translational termination (GO:0006415)3.26831810
54folic acid-containing compound biosynthetic process (GO:0009396)3.25599322
55DNA damage response, detection of DNA damage (GO:0042769)3.25474237
56mitotic nuclear envelope disassembly (GO:0007077)3.24191929
57ribosomal small subunit biogenesis (GO:0042274)3.22593511
58ribosomal large subunit biogenesis (GO:0042273)3.22166887
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21611019
60negative regulation of ligase activity (GO:0051352)3.21186517
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21186517
62attachment of spindle microtubules to kinetochore (GO:0008608)3.19936945
63protein localization to chromosome, centromeric region (GO:0071459)3.19780189
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18725825
65regulation of mitotic spindle checkpoint (GO:1903504)3.18725825
66establishment of chromosome localization (GO:0051303)3.18659361
67rRNA metabolic process (GO:0016072)3.17139477
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16508926
69mitochondrial RNA metabolic process (GO:0000959)3.16073237
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15415140
71ATP synthesis coupled proton transport (GO:0015986)3.15415140
727-methylguanosine mRNA capping (GO:0006370)3.14161908
73DNA replication-independent nucleosome assembly (GO:0006336)3.12955245
74DNA replication-independent nucleosome organization (GO:0034724)3.12955245
75translational initiation (GO:0006413)3.12277774
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11526444
77mitochondrial respiratory chain complex I assembly (GO:0032981)3.11526444
78NADH dehydrogenase complex assembly (GO:0010257)3.11526444
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11027592
80mitochondrial respiratory chain complex assembly (GO:0033108)3.10661308
81RNA capping (GO:0036260)3.10249306
827-methylguanosine RNA capping (GO:0009452)3.10249306
83establishment of viral latency (GO:0019043)3.09822418
84peptidyl-histidine modification (GO:0018202)3.09469296
85negative regulation of DNA-dependent DNA replication (GO:2000104)3.09162170
86transcription-coupled nucleotide-excision repair (GO:0006283)3.08217402
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06888853
88establishment of protein localization to mitochondrion (GO:0072655)3.04088007
89tRNA aminoacylation for protein translation (GO:0006418)3.03998802
90translational elongation (GO:0006414)3.03862831
91nucleotide-excision repair, DNA gap filling (GO:0006297)3.03316647
92tRNA aminoacylation (GO:0043039)3.02136630
93amino acid activation (GO:0043038)3.02136630
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02135700
95rRNA modification (GO:0000154)3.02098704
96protein complex biogenesis (GO:0070271)3.01662711
97protein localization to mitochondrion (GO:0070585)3.01633278
98signal transduction involved in cell cycle checkpoint (GO:0072395)3.00732425
99somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99658280
100isotype switching (GO:0045190)2.99658280
101somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99658280
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99653448
103protein K6-linked ubiquitination (GO:0085020)2.99576744
104viral mRNA export from host cell nucleus (GO:0046784)2.99421597
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98963965
106regulation of ubiquitin-protein transferase activity (GO:0051438)2.98331960
107regulation of nuclear cell cycle DNA replication (GO:0033262)2.98294699
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97047841
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97047841
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96588811
111negative regulation of sister chromatid segregation (GO:0033046)2.96588811
112negative regulation of mitotic sister chromatid separation (GO:2000816)2.96588811
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96588811
114negative regulation of chromosome segregation (GO:0051985)2.96359850
115G1/S transition of mitotic cell cycle (GO:0000082)2.94260696
116cell cycle G1/S phase transition (GO:0044843)2.94260696
117nuclear envelope disassembly (GO:0051081)2.93964380
118membrane disassembly (GO:0030397)2.93964380
119positive regulation of ligase activity (GO:0051351)2.91657503
120cotranslational protein targeting to membrane (GO:0006613)2.91419346
121protein targeting to ER (GO:0045047)2.89258346
122mitotic spindle assembly checkpoint (GO:0007094)2.88921404
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87612930
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84554225
125signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84554225
126spindle assembly checkpoint (GO:0071173)2.84261385
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84014109
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84014109
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84014109
130termination of RNA polymerase I transcription (GO:0006363)2.83811365
131DNA replication-dependent nucleosome organization (GO:0034723)2.83458841
132DNA replication-dependent nucleosome assembly (GO:0006335)2.83458841
133transcription elongation from RNA polymerase I promoter (GO:0006362)2.82845454
134translation (GO:0006412)2.82768663
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82613654
136metallo-sulfur cluster assembly (GO:0031163)2.80837455
137iron-sulfur cluster assembly (GO:0016226)2.80837455
138cellular component biogenesis (GO:0044085)2.80205078
139spindle checkpoint (GO:0031577)2.79417629
140signal transduction involved in DNA damage checkpoint (GO:0072422)2.78514947
141signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78514947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02848386
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.01734475
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63726345
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29821155
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.26430659
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.22249494
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.17728602
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99008600
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.96590699
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94341178
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.91300102
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84513087
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73999655
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72851482
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66295031
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58490143
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51198154
18* VDR_23849224_ChIP-Seq_CD4+_Human2.36540828
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30439227
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25526181
21XRN2_22483619_ChIP-Seq_HELA_Human2.25520347
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24476042
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18063330
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14809705
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12980224
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07184081
27FOXP3_21729870_ChIP-Seq_TREG_Human2.06944945
28DCP1A_22483619_ChIP-Seq_HELA_Human2.06735911
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98184647
30* GABP_19822575_ChIP-Seq_HepG2_Human1.97956135
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84846502
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.83375332
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82198741
34* SRF_21415370_ChIP-Seq_HL-1_Mouse1.77375540
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77127270
36AR_21909140_ChIP-Seq_LNCAP_Human1.74468792
37CIITA_25753668_ChIP-Seq_RAJI_Human1.72367047
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71362255
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70192694
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69817264
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68741654
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.68280517
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68090517
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67994936
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.67464145
46TTF2_22483619_ChIP-Seq_HELA_Human1.67214915
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66504138
48* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61874115
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61333338
50MYC_22102868_ChIP-Seq_BL_Human1.56616356
51* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55943497
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55390527
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.51573220
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50860998
55ELK1_19687146_ChIP-ChIP_HELA_Human1.49970993
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48885018
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46691001
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43251954
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.39752271
60KDM5A_27292631_Chip-Seq_BREAST_Human1.35219938
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34140590
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31647929
63SPI1_23547873_ChIP-Seq_NB4_Human1.29372996
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23553596
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21377215
66ZNF274_21170338_ChIP-Seq_K562_Hela1.21210238
67VDR_21846776_ChIP-Seq_THP-1_Human1.19893231
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19622609
69TFEB_21752829_ChIP-Seq_HELA_Human1.19145249
70EWS_26573619_Chip-Seq_HEK293_Human1.19133125
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17002368
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.16817794
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14410073
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14007361
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13307202
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12689397
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08870469
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08750633
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08670366
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08596229
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08244491
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06391663
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06308960
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02208900
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99203860
86IRF8_21731497_ChIP-ChIP_J774_Mouse0.98938350
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98440192
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.97838518
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97284443
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96941209
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96751928
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95469043
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.94367046
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.93257021
95* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91432891
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.91259980
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90454332
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90394515
99MYC_18940864_ChIP-ChIP_HL60_Human0.89881810
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89678499
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89311284
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87710117
103IRF1_19129219_ChIP-ChIP_H3396_Human0.86458842
104* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86059598
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85861458
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84775138
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83173279
108* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81674221
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80932278
110STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80549390
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80171837
112* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79882568
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79042365
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78683406
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77669216
116FUS_26573619_Chip-Seq_HEK293_Human0.77450660
117FLI1_27457419_Chip-Seq_LIVER_Mouse0.76523899
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75818952
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74163851
120ELF5_23300383_ChIP-Seq_T47D_Human0.72854796
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70635803
122* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68871663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.34311792
2MP0004957_abnormal_blastocyst_morpholog4.24269789
3MP0003111_abnormal_nucleus_morphology4.09485318
4MP0010094_abnormal_chromosome_stability4.08359441
5MP0003077_abnormal_cell_cycle3.83070019
6MP0008057_abnormal_DNA_replication3.51317950
7MP0008058_abnormal_DNA_repair3.01169140
8MP0002396_abnormal_hematopoietic_system2.95026365
9MP0008007_abnormal_cellular_replicative2.82736133
10MP0009697_abnormal_copulation2.54719117
11MP0003718_maternal_effect2.46001761
12MP0008932_abnormal_embryonic_tissue2.38020562
13MP0009333_abnormal_splenocyte_physiolog2.25559874
14MP0003941_abnormal_skin_development2.24337547
15MP0001545_abnormal_hematopoietic_system1.99699267
16MP0005397_hematopoietic_system_phenotyp1.99699267
17MP0001835_abnormal_antigen_presentation1.99274244
18MP0000490_abnormal_crypts_of1.96109018
19* MP0001730_embryonic_growth_arrest1.94958686
20MP0000350_abnormal_cell_proliferation1.92382675
21MP0006054_spinal_hemorrhage1.89190029
22MP0004808_abnormal_hematopoietic_stem1.83659211
23MP0005671_abnormal_response_to1.78189515
24MP0003763_abnormal_thymus_physiology1.75311258
25MP0002398_abnormal_bone_marrow1.74640418
26MP0001293_anophthalmia1.71315981
27MP0002938_white_spotting1.71080783
28MP0000685_abnormal_immune_system1.70059948
29MP0000372_irregular_coat_pigmentation1.69060946
30MP0003806_abnormal_nucleotide_metabolis1.62104114
31MP0008260_abnormal_autophagy1.59940294
32MP0002019_abnormal_tumor_incidence1.58977021
33MP0000689_abnormal_spleen_morphology1.55972817
34MP0002722_abnormal_immune_system1.53416957
35MP0003436_decreased_susceptibility_to1.52393300
36MP0003786_premature_aging1.51115584
37MP0009785_altered_susceptibility_to1.48756926
38MP0008789_abnormal_olfactory_epithelium1.48740105
39MP0010307_abnormal_tumor_latency1.44967090
40MP0001800_abnormal_humoral_immune1.43814225
41* MP0000313_abnormal_cell_death1.43587552
42MP0002429_abnormal_blood_cell1.42193094
43MP0003186_abnormal_redox_activity1.42093031
44MP0000716_abnormal_immune_system1.41754008
45MP0002254_reproductive_system_inflammat1.40748719
46MP0003937_abnormal_limbs/digits/tail_de1.40507310
47MP0009840_abnormal_foam_cell1.37666348
48MP0002452_abnormal_antigen_presenting1.37657784
49MP0001529_abnormal_vocalization1.36874179
50MP0008877_abnormal_DNA_methylation1.36739996
51* MP0001697_abnormal_embryo_size1.34881284
52MP0002723_abnormal_immune_serum1.34791511
53MP0002420_abnormal_adaptive_immunity1.34090871
54* MP0002080_prenatal_lethality1.34062558
55MP0001819_abnormal_immune_cell1.32749397
56MP0005025_abnormal_response_to1.30875839
57MP0001672_abnormal_embryogenesis/_devel1.29368239
58MP0005380_embryogenesis_phenotype1.29368239
59MP0002163_abnormal_gland_morphology1.28896462
60MP0010030_abnormal_orbit_morphology1.28596397
61MP0000703_abnormal_thymus_morphology1.28235151
62MP0005000_abnormal_immune_tolerance1.27379736
63MP0005075_abnormal_melanosome_morpholog1.26462200
64MP0003123_paternal_imprinting1.22543026
65MP0000465_gastrointestinal_hemorrhage1.20261032
66MP0003984_embryonic_growth_retardation1.19044838
67MP0006072_abnormal_retinal_apoptosis1.17631688
68MP0002736_abnormal_nociception_after1.16660209
69MP0003567_abnormal_fetal_cardiomyocyte1.15031612
70MP0003890_abnormal_embryonic-extraembry1.14582445
71MP0002088_abnormal_embryonic_growth/wei1.14318049
72MP0000049_abnormal_middle_ear1.10861348
73MP0008995_early_reproductive_senescence1.10604691
74MP0002419_abnormal_innate_immunity1.09466868
75MP0000858_altered_metastatic_potential1.08241755
76* MP0006036_abnormal_mitochondrial_physio1.08150159
77MP0010352_gastrointestinal_tract_polyps1.07100944
78* MP0000358_abnormal_cell_content/1.06735757
79MP0005408_hypopigmentation1.06019992
80MP0006292_abnormal_olfactory_placode1.05809657
81MP0002210_abnormal_sex_determination1.04005575
82MP0001873_stomach_inflammation1.03884458
83MP0004197_abnormal_fetal_growth/weight/1.01791451
84MP0002148_abnormal_hypersensitivity_rea0.98228739
85MP0002085_abnormal_embryonic_tissue0.97185622
86MP0002405_respiratory_system_inflammati0.94531067
87MP0005084_abnormal_gallbladder_morpholo0.94471794
88MP0005389_reproductive_system_phenotype0.94217142
89MP0003656_abnormal_erythrocyte_physiolo0.93979032
90MP0002086_abnormal_extraembryonic_tissu0.93746192
91MP0001286_abnormal_eye_development0.93537653
92MP0002233_abnormal_nose_morphology0.91900079
93MP0001145_abnormal_male_reproductive0.90743042
94MP0002006_tumorigenesis0.90547957
95MP0001764_abnormal_homeostasis0.90472091
96MP0005058_abnormal_lysosome_morphology0.89945169
97MP0002132_abnormal_respiratory_system0.89916469
98MP0001661_extended_life_span0.89677764
99MP0003221_abnormal_cardiomyocyte_apopto0.89428885
100MP0001853_heart_inflammation0.88493243
101MP0002166_altered_tumor_susceptibility0.88462726
102MP0001119_abnormal_female_reproductive0.88301793
103MP0009278_abnormal_bone_marrow0.87590758
104MP0005394_taste/olfaction_phenotype0.86525362
105MP0005499_abnormal_olfactory_system0.86525362
106MP0002095_abnormal_skin_pigmentation0.85304569
107MP0005464_abnormal_platelet_physiology0.85298994
108MP0009672_abnormal_birth_weight0.84794680
109MP0003195_calcinosis0.84686338
110MP0001929_abnormal_gametogenesis0.83956069
111MP0002084_abnormal_developmental_patter0.81650948
112MP0003121_genomic_imprinting0.81369181
113MP0000653_abnormal_sex_gland0.81285267
114MP0001790_abnormal_immune_system0.80973846
115MP0005387_immune_system_phenotype0.80973846
116MP0003119_abnormal_digestive_system0.80839388
117MP0001188_hyperpigmentation0.80290487
118MP0000631_abnormal_neuroendocrine_gland0.79287892
119MP0001542_abnormal_bone_strength0.78835975
120MP0001845_abnormal_inflammatory_respons0.78735335
121MP0004133_heterotaxia0.77315609
122MP0001727_abnormal_embryo_implantation0.76235884
123MP0002697_abnormal_eye_size0.76206135
124MP0002111_abnormal_tail_morphology0.74866251
125MP0003315_abnormal_perineum_morphology0.74770442
126MP0010155_abnormal_intestine_physiology0.74411169
127* MP0005384_cellular_phenotype0.74173549
128MP0000647_abnormal_sebaceous_gland0.74021532
129MP0003646_muscle_fatigue0.73725382
130MP0005621_abnormal_cell_physiology0.73253135
131MP0009703_decreased_birth_body0.72791706
132MP0002102_abnormal_ear_morphology0.72363456
133MP0002234_abnormal_pharynx_morphology0.72127821
134* MP0006035_abnormal_mitochondrial_morpho0.71388348
135MP0005379_endocrine/exocrine_gland_phen0.70245223
136MP0004147_increased_porphyrin_level0.69892728
137MP0003950_abnormal_plasma_membrane0.69503177
138MP0008469_abnormal_protein_level0.68986037
139MP0000015_abnormal_ear_pigmentation0.67461113
140MP0002751_abnormal_autonomic_nervous0.66776811
141MP0003755_abnormal_palate_morphology0.66384964
142MP0003698_abnormal_male_reproductive0.65754929
143MP0005395_other_phenotype0.65529526
144MP0005310_abnormal_salivary_gland0.65181131
145MP0006082_CNS_inflammation0.64490220
146MP0005501_abnormal_skin_physiology0.64044659
147MP0002160_abnormal_reproductive_system0.63511827
148MP0005367_renal/urinary_system_phenotyp0.60868900
149MP0000516_abnormal_urinary_system0.60868900
150MP0005391_vision/eye_phenotype0.60052244
151MP0002090_abnormal_vision0.59763821
152MP0005253_abnormal_eye_physiology0.58664362
153MP0003942_abnormal_urinary_system0.58264414
154MP0002138_abnormal_hepatobiliary_system0.56054490

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.19052200
2Abnormal number of erythroid precursors (HP:0012131)5.18818875
3Abnormality of cells of the erythroid lineage (HP:0012130)5.10697239
4Breast hypoplasia (HP:0003187)4.32470578
5Acute necrotizing encephalopathy (HP:0006965)4.15936731
6Aplastic anemia (HP:0001915)3.95530877
7Acute encephalopathy (HP:0006846)3.83634946
8Reticulocytopenia (HP:0001896)3.79371720
9Abnormal mitochondria in muscle tissue (HP:0008316)3.75975659
10Cerebral hypomyelination (HP:0006808)3.64623283
11Increased CSF lactate (HP:0002490)3.64068713
12Mitochondrial inheritance (HP:0001427)3.61584367
13Type I transferrin isoform profile (HP:0003642)3.57340705
14Thrombocytosis (HP:0001894)3.41259198
15Rough bone trabeculation (HP:0100670)3.32652522
16Increased hepatocellular lipid droplets (HP:0006565)3.29531432
17Progressive macrocephaly (HP:0004481)3.29074790
18Oral leukoplakia (HP:0002745)3.27016200
19Lipid accumulation in hepatocytes (HP:0006561)3.15998019
20Progressive muscle weakness (HP:0003323)3.12929011
21Reduced antithrombin III activity (HP:0001976)3.10047904
22Abnormality of the labia minora (HP:0012880)3.09191337
23Carpal bone hypoplasia (HP:0001498)2.99309175
24Hepatic necrosis (HP:0002605)2.98924802
25Cerebral edema (HP:0002181)2.94037749
26Microvesicular hepatic steatosis (HP:0001414)2.90614727
27Patellar aplasia (HP:0006443)2.87424417
28CNS hypomyelination (HP:0003429)2.82977046
29Pallor (HP:0000980)2.79747429
30Abnormality of the preputium (HP:0100587)2.74456133
31Microretrognathia (HP:0000308)2.74068899
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73743443
33Abnormality of the anterior horn cell (HP:0006802)2.71036531
34Degeneration of anterior horn cells (HP:0002398)2.71036531
35Chromsome breakage (HP:0040012)2.70989360
36Aplasia/Hypoplasia of the patella (HP:0006498)2.70551147
37Bone marrow hypocellularity (HP:0005528)2.69859543
38Macrocytic anemia (HP:0001972)2.67175412
39Methylmalonic acidemia (HP:0002912)2.65605366
40Selective tooth agenesis (HP:0001592)2.64189993
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.62774146
42Abnormal protein N-linked glycosylation (HP:0012347)2.62774146
43Abnormal protein glycosylation (HP:0012346)2.62774146
44Abnormal glycosylation (HP:0012345)2.62774146
45Meckel diverticulum (HP:0002245)2.62006808
46Chronic otitis media (HP:0000389)2.61230644
47Absent radius (HP:0003974)2.60116124
48Myelodysplasia (HP:0002863)2.58493752
49Horseshoe kidney (HP:0000085)2.58166593
50Abnormal trabecular bone morphology (HP:0100671)2.57974411
51Abnormality of methionine metabolism (HP:0010901)2.53820038
52Abnormal lung lobation (HP:0002101)2.52384223
53Lactic acidosis (HP:0003128)2.52093768
54Abnormality of the ileum (HP:0001549)2.51597525
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49329507
56Premature ovarian failure (HP:0008209)2.49093729
57Abnormality of chromosome stability (HP:0003220)2.48055288
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45837316
59Premature graying of hair (HP:0002216)2.45243878
60Renal Fanconi syndrome (HP:0001994)2.41465936
61Recurrent abscess formation (HP:0002722)2.40732081
62Absent thumb (HP:0009777)2.40194085
63Absent forearm bone (HP:0003953)2.38825965
64Aplasia involving forearm bones (HP:0009822)2.38825965
65Multiple enchondromatosis (HP:0005701)2.37783515
66Pancytopenia (HP:0001876)2.37241317
67Ependymoma (HP:0002888)2.35928887
68Increased serum pyruvate (HP:0003542)2.35089525
69Methylmalonic aciduria (HP:0012120)2.33354512
70Agnosia (HP:0010524)2.32517843
71Muscle fiber atrophy (HP:0100295)2.32085129
72Increased serum lactate (HP:0002151)2.31420259
73Abnormality of serum amino acid levels (HP:0003112)2.30423000
743-Methylglutaconic aciduria (HP:0003535)2.30202116
75Hyperglycinemia (HP:0002154)2.28534279
76Secondary amenorrhea (HP:0000869)2.27666550
77Hypoplastic pelvis (HP:0008839)2.26410602
78Respiratory failure (HP:0002878)2.26011707
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.24095307
80Abnormality of the heme biosynthetic pathway (HP:0010472)2.22660238
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21515667
82Lymphoma (HP:0002665)2.19248897
83Duodenal stenosis (HP:0100867)2.18122543
84Small intestinal stenosis (HP:0012848)2.18122543
85Abnormality of glycolysis (HP:0004366)2.17361618
86Elevated erythrocyte sedimentation rate (HP:0003565)2.17192324
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16530564
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16530564
89IgM deficiency (HP:0002850)2.13967295
90Type 2 muscle fiber atrophy (HP:0003554)2.13506189
91Hypoplasia of the pons (HP:0012110)2.13265114
92Abnormality of the duodenum (HP:0002246)2.12197690
93Exercise intolerance (HP:0003546)2.11565233
94Severe visual impairment (HP:0001141)2.10153700
95Abnormality of T cell physiology (HP:0011840)2.08676773
96Recurrent bacterial skin infections (HP:0005406)2.08554644
97Personality changes (HP:0000751)2.07302484
98Abnormality of macrophages (HP:0004311)2.07278439
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06151952
100Stenosis of the external auditory canal (HP:0000402)2.05761356
101Neoplasm of the pancreas (HP:0002894)2.05273018
102Abnormality of alanine metabolism (HP:0010916)2.03505427
103Abnormality of the carotid arteries (HP:0005344)2.02924832
104Abnormality of the pons (HP:0007361)2.01445468
105Leukodystrophy (HP:0002415)2.00859977
106IgG deficiency (HP:0004315)2.00739447
107Increased intramyocellular lipid droplets (HP:0012240)2.00687870
108Sloping forehead (HP:0000340)2.00373418
109Cellular immunodeficiency (HP:0005374)1.98342034
110Tongue fasciculations (HP:0001308)1.97622386
111Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97436174
112Optic nerve coloboma (HP:0000588)1.96621015
113Hypergonadotropic hypogonadism (HP:0000815)1.96603453
114Respiratory difficulties (HP:0002880)1.95494766
115Generalized aminoaciduria (HP:0002909)1.94077378
116Nephroblastoma (Wilms tumor) (HP:0002667)1.93886218
117Petechiae (HP:0000967)1.93803390
118Megaloblastic anemia (HP:0001889)1.93536142
119Trismus (HP:0000211)1.93208360
120Triphalangeal thumb (HP:0001199)1.92991889
121Pendular nystagmus (HP:0012043)1.92320218
122Lethargy (HP:0001254)1.91577530
123Abnormality of the umbilical cord (HP:0010881)1.89769035
124Homocystinuria (HP:0002156)1.88110249
125Abnormality of homocysteine metabolism (HP:0010919)1.88110249
126Embryonal renal neoplasm (HP:0011794)1.88022721
127Exertional dyspnea (HP:0002875)1.87762976
128Duplicated collecting system (HP:0000081)1.87687068
129Medulloblastoma (HP:0002885)1.87069967
130Rhabdomyosarcoma (HP:0002859)1.85988710
131Abnormal spermatogenesis (HP:0008669)1.85762665
132Tracheoesophageal fistula (HP:0002575)1.84365956
133Prominent nose (HP:0000448)1.84159009
134Entropion (HP:0000621)1.84039633
135Clubbing of toes (HP:0100760)1.83839900
136CNS demyelination (HP:0007305)1.83836599
137Ectopic kidney (HP:0000086)1.83454491
138Postnatal microcephaly (HP:0005484)1.82434994
139Facial cleft (HP:0002006)1.82147839
140Colon cancer (HP:0003003)1.82067108
141Upper motor neuron abnormality (HP:0002127)1.82045731
142Abnormality of the renal collecting system (HP:0004742)1.80807737
143Hepatocellular necrosis (HP:0001404)1.79834108
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78636629
145Hyperalaninemia (HP:0003348)1.78636629
146Pancreatic cysts (HP:0001737)1.78314434
147Small hand (HP:0200055)1.77947041
148Amniotic constriction ring (HP:0009775)1.76468191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.98670609
2WEE14.31867660
3STK163.40308622
4PBK3.18910426
5VRK23.17287628
6NME23.04028994
7EIF2AK12.73273832
8CDC72.57484711
9NEK22.47637310
10NUAK12.06599426
11EIF2AK32.05805202
12PLK42.05334906
13TRIM281.96685397
14NEK11.95639219
15MAP4K11.94785967
16TSSK61.93352897
17SRPK11.93244404
18PDK21.87595345
19BRSK21.87451527
20NME11.86753855
21CCNB11.83110127
22PLK11.76568234
23ACVR1B1.76269520
24DYRK31.71818725
25VRK11.67479736
26TTK1.63669317
27TAF11.60487814
28BCKDK1.57202783
29PIM21.55534706
30FLT31.39690840
31MKNK11.37484072
32RPS6KB21.34826651
33WNK31.33739264
34CDK71.30621354
35AURKB1.27020329
36STK391.22776842
37ATR1.22627526
38PASK1.21113073
39CDK81.20957098
40KIT1.19054463
41STK101.18890495
42TESK21.18392371
43IRAK41.18294263
44MAP3K81.14564550
45MAP2K31.13699958
46BRSK11.13551879
47CDK41.10709365
48MAP3K111.09897560
49RPS6KA41.09190785
50BTK1.08361203
51ERBB41.08133381
52TEC1.07565881
53KDR1.05821350
54WNK41.03843418
55PLK21.02342046
56AURKA1.00928932
57CHEK20.99072215
58MAP3K40.99065939
59IRAK30.99012230
60MKNK20.98910918
61OXSR10.97646211
62EIF2AK20.97319593
63TLK10.93455129
64MAP2K70.91817946
65TGFBR10.88822799
66MOS0.87732665
67BCR0.87104630
68MAPKAPK30.86387007
69ARAF0.85139449
70PIM10.84494584
71ZAP700.83875821
72SCYL20.83630747
73CSF1R0.83448133
74CLK10.82523783
75CSNK1G10.80742867
76BRAF0.80691492
77PLK30.78466236
78TYK20.78304925
79CHEK10.78071832
80TXK0.75375677
81EEF2K0.74679406
82BMPR1B0.72194953
83PAK40.71049350
84ZAK0.69414388
85NLK0.67822189
86ALK0.67436720
87MELK0.66995955
88LRRK20.66936078
89IKBKB0.65196525
90ERBB30.65175253
91CSNK1A1L0.61920535
92BLK0.61729062
93MAP4K20.59536714
94GRK10.59359834
95CSNK1G20.59041334
96MAP3K30.58966545
97STK30.58658388
98RAF10.57756293
99CSNK2A10.57533098
100CSNK2A20.57450340
101PRKCI0.56880171
102MST40.56194213
103JAK30.55685316
104TBK10.52934010
105PAK10.52888297
106CDK20.52478485
107EPHA20.51530114
108DYRK20.51236561
109CSNK1E0.50526945
110LYN0.49794076
111SYK0.49710800
112ATM0.49477849
113TNIK0.49077900
114ABL20.47920355
115CDK90.47415243
116ADRBK20.46889476
117RPS6KA50.45498991
118STK40.42849373
119LIMK10.40374625
120PINK10.39412010
121CDK30.37948630
122GRK60.34992757
123DAPK10.34490183
124PRKDC0.33086591
125CSNK1G30.32955423
126MAP3K120.32875552
127CDK190.32082316
128TAOK30.31963045
129INSRR0.31536346
130ITK0.31378223
131CDK10.30707584
132STK240.30532067
133ILK0.30367259
134PKN20.30115835
135STK38L0.29338236
136MUSK0.29130616
137PAK20.27740499
138CSNK1A10.23229041
139PRKCG0.22571306
140AKT20.22437235

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030304.71003994
2RNA polymerase_Homo sapiens_hsa030203.89071612
3Mismatch repair_Homo sapiens_hsa034303.66206790
4Proteasome_Homo sapiens_hsa030503.58531511
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57379036
6Ribosome_Homo sapiens_hsa030103.43869947
7Base excision repair_Homo sapiens_hsa034103.07186739
8Spliceosome_Homo sapiens_hsa030402.93148993
9Homologous recombination_Homo sapiens_hsa034402.86667515
10RNA transport_Homo sapiens_hsa030132.69263528
11Pyrimidine metabolism_Homo sapiens_hsa002402.67435136
12Nucleotide excision repair_Homo sapiens_hsa034202.56776899
13Cell cycle_Homo sapiens_hsa041102.38873599
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03276670
15Folate biosynthesis_Homo sapiens_hsa007902.00262030
16Fanconi anemia pathway_Homo sapiens_hsa034601.96877131
17Basal transcription factors_Homo sapiens_hsa030221.89175524
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88817646
19One carbon pool by folate_Homo sapiens_hsa006701.84900905
20RNA degradation_Homo sapiens_hsa030181.79413424
21Non-homologous end-joining_Homo sapiens_hsa034501.72960005
22Fatty acid elongation_Homo sapiens_hsa000621.49098654
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47838959
24Purine metabolism_Homo sapiens_hsa002301.44095092
25Protein export_Homo sapiens_hsa030601.42243652
26p53 signaling pathway_Homo sapiens_hsa041151.35713801
27Vitamin B6 metabolism_Homo sapiens_hsa007501.32418476
28Pyruvate metabolism_Homo sapiens_hsa006201.32143969
29Epstein-Barr virus infection_Homo sapiens_hsa051691.26829558
30Propanoate metabolism_Homo sapiens_hsa006401.25313278
31Alzheimers disease_Homo sapiens_hsa050101.25011214
32Sulfur relay system_Homo sapiens_hsa041221.14654152
33mRNA surveillance pathway_Homo sapiens_hsa030151.10372547
34Pentose phosphate pathway_Homo sapiens_hsa000301.10054229
35Herpes simplex infection_Homo sapiens_hsa051681.09733579
36Steroid biosynthesis_Homo sapiens_hsa001001.09128121
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06365913
38Antigen processing and presentation_Homo sapiens_hsa046121.05671323
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98786809
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98471095
41Sulfur metabolism_Homo sapiens_hsa009200.95249088
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.93224187
43Primary immunodeficiency_Homo sapiens_hsa053400.87967111
44Legionellosis_Homo sapiens_hsa051340.76306880
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74498742
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72374082
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71606436
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.71493872
49Biosynthesis of amino acids_Homo sapiens_hsa012300.71388994
50Oocyte meiosis_Homo sapiens_hsa041140.70622474
51Allograft rejection_Homo sapiens_hsa053300.70412611
52Systemic lupus erythematosus_Homo sapiens_hsa053220.70085237
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70010425
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.69833796
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69491879
56Viral carcinogenesis_Homo sapiens_hsa052030.69237257
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66744346
58Glutathione metabolism_Homo sapiens_hsa004800.65656623
59Cardiac muscle contraction_Homo sapiens_hsa042600.63489464
60Selenocompound metabolism_Homo sapiens_hsa004500.63341577
61N-Glycan biosynthesis_Homo sapiens_hsa005100.62341321
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.62207234
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.61623230
64Measles_Homo sapiens_hsa051620.61441092
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61272796
66Regulation of autophagy_Homo sapiens_hsa041400.56072938
67Leishmaniasis_Homo sapiens_hsa051400.54879260
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54780943
69Thyroid cancer_Homo sapiens_hsa052160.54586130
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54021153
71Shigellosis_Homo sapiens_hsa051310.51769818
72Peroxisome_Homo sapiens_hsa041460.50512731
73HTLV-I infection_Homo sapiens_hsa051660.50043243
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49343196
75Parkinsons disease_Homo sapiens_hsa050120.49100176
76Huntingtons disease_Homo sapiens_hsa050160.48927564
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48078651
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47804620
79Fructose and mannose metabolism_Homo sapiens_hsa000510.47574057
80Other glycan degradation_Homo sapiens_hsa005110.47524141
81Fatty acid metabolism_Homo sapiens_hsa012120.46333531
82Apoptosis_Homo sapiens_hsa042100.45514479
83Hematopoietic cell lineage_Homo sapiens_hsa046400.43897432
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42602069
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42160188
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38406119
87Tryptophan metabolism_Homo sapiens_hsa003800.37999559
88Influenza A_Homo sapiens_hsa051640.37659915
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37553359
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37138464
91Carbon metabolism_Homo sapiens_hsa012000.36467431
92Metabolic pathways_Homo sapiens_hsa011000.36255851
93Asthma_Homo sapiens_hsa053100.35761452
94Butanoate metabolism_Homo sapiens_hsa006500.34150986
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33360202
96Hepatitis B_Homo sapiens_hsa051610.31486474
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30735433
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30666190
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28474318
100Oxidative phosphorylation_Homo sapiens_hsa001900.27972546
101Small cell lung cancer_Homo sapiens_hsa052220.27536177
102Graft-versus-host disease_Homo sapiens_hsa053320.27318646
103Type I diabetes mellitus_Homo sapiens_hsa049400.26254749
104Fatty acid degradation_Homo sapiens_hsa000710.24170640
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23988454
106Galactose metabolism_Homo sapiens_hsa000520.22921282
107B cell receptor signaling pathway_Homo sapiens_hsa046620.22709228
108Notch signaling pathway_Homo sapiens_hsa043300.22483627
109beta-Alanine metabolism_Homo sapiens_hsa004100.22356313
110Lysine degradation_Homo sapiens_hsa003100.22122935
111Arachidonic acid metabolism_Homo sapiens_hsa005900.21722313
112Vitamin digestion and absorption_Homo sapiens_hsa049770.20422347
113Lysosome_Homo sapiens_hsa041420.20039235
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.19900879
115TGF-beta signaling pathway_Homo sapiens_hsa043500.19881450
116Phototransduction_Homo sapiens_hsa047440.19614923
117Acute myeloid leukemia_Homo sapiens_hsa052210.18908394
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18214824
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17950695
120Basal cell carcinoma_Homo sapiens_hsa052170.16462946
121MicroRNAs in cancer_Homo sapiens_hsa052060.15880017
122Collecting duct acid secretion_Homo sapiens_hsa049660.14994530
123Arginine and proline metabolism_Homo sapiens_hsa003300.14976398
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14938770
125Hedgehog signaling pathway_Homo sapiens_hsa043400.14680680
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13692164
127Autoimmune thyroid disease_Homo sapiens_hsa053200.12822367
128Linoleic acid metabolism_Homo sapiens_hsa005910.11900554
129Retinol metabolism_Homo sapiens_hsa008300.09155217
130Alcoholism_Homo sapiens_hsa050340.08988795
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08579684
132Melanoma_Homo sapiens_hsa052180.08160371
133Wnt signaling pathway_Homo sapiens_hsa043100.06594784
134Hippo signaling pathway_Homo sapiens_hsa043900.06544243
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.02122236
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00788570

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