RNASE9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tolerance induction (GO:0002645)9.43051525
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)8.82249792
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)8.82249792
4kynurenine metabolic process (GO:0070189)8.57248088
5sperm capacitation (GO:0048240)8.41692552
6regulation of tolerance induction (GO:0002643)8.17403394
7antigen processing and presentation via MHC class Ib (GO:0002475)8.09496486
8regulation of clathrin-mediated endocytosis (GO:2000369)7.37433454
9antigen processing and presentation of endogenous antigen (GO:0019883)7.31428404
10regulation of antigen processing and presentation of peptide antigen (GO:0002583)7.06831210
11regulation of chronic inflammatory response (GO:0002676)6.79089545
12tryptophan catabolic process (GO:0006569)6.45639821
13indole-containing compound catabolic process (GO:0042436)6.45639821
14indolalkylamine catabolic process (GO:0046218)6.45639821
15single fertilization (GO:0007338)6.42029150
16heterotypic cell-cell adhesion (GO:0034113)6.28887576
17tryptophan metabolic process (GO:0006568)5.52350682
18negative regulation of interleukin-10 production (GO:0032693)5.47981257
19positive regulation of type 2 immune response (GO:0002830)5.47030249
20negative regulation of receptor-mediated endocytosis (GO:0048261)4.92014240
21negative regulation of endopeptidase activity (GO:0010951)4.87489593
22sulfur amino acid catabolic process (GO:0000098)4.78552199
23negative regulation of peptidase activity (GO:0010466)4.65860538
24aromatic amino acid family catabolic process (GO:0009074)4.56036060
25complement activation, alternative pathway (GO:0006957)4.47959261
26benzene-containing compound metabolic process (GO:0042537)4.44449924
27fertilization (GO:0009566)4.20023126
28regulation of acrosome reaction (GO:0060046)4.19025034
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.16792160
30amine catabolic process (GO:0009310)4.09932432
31cellular biogenic amine catabolic process (GO:0042402)4.09932432
32fusion of sperm to egg plasma membrane (GO:0007342)4.08495479
33indolalkylamine metabolic process (GO:0006586)3.98657566
34negative regulation of interleukin-8 production (GO:0032717)3.84249457
35negative regulation of protein autophosphorylation (GO:0031953)3.77690809
36alpha-linolenic acid metabolic process (GO:0036109)3.76096787
37valine metabolic process (GO:0006573)3.64081464
38response to misfolded protein (GO:0051788)3.63835468
39low-density lipoprotein particle clearance (GO:0034383)3.56248494
40negative regulation of T cell apoptotic process (GO:0070233)3.46914874
41phospholipid homeostasis (GO:0055091)3.46576814
42epithelial cell morphogenesis (GO:0003382)3.42734080
43aromatic amino acid family metabolic process (GO:0009072)3.42333922
44digestion (GO:0007586)3.38513070
45positive regulation of antigen processing and presentation (GO:0002579)3.37185349
46reverse cholesterol transport (GO:0043691)3.29869728
47regulation of lipoprotein metabolic process (GO:0050746)3.28633326
48negative regulation of proteolysis (GO:0045861)3.22148608
49triglyceride catabolic process (GO:0019433)3.18068751
50macroautophagy (GO:0016236)3.16081960
51plasma membrane fusion (GO:0045026)3.15077719
52negative regulation of protein processing (GO:0010955)3.10076798
53negative regulation of protein maturation (GO:1903318)3.10076798
54defense response to bacterium (GO:0042742)3.05696658
55positive regulation of cell-cell adhesion (GO:0022409)3.00747859
56cysteine metabolic process (GO:0006534)3.00586602
57neutral lipid catabolic process (GO:0046461)2.98404833
58acylglycerol catabolic process (GO:0046464)2.98404833
59regulation of Cdc42 GTPase activity (GO:0043088)2.98093085
60L-serine transport (GO:0015825)2.97252601
61transepithelial transport (GO:0070633)2.93096220
62regulation of type 2 immune response (GO:0002828)2.85658255
63indole-containing compound metabolic process (GO:0042430)2.83795671
64negative regulation of hydrolase activity (GO:0051346)2.80159397
65positive regulation of cholesterol transport (GO:0032376)2.77875163
66positive regulation of sterol transport (GO:0032373)2.77875163
67COPI coating of Golgi vesicle (GO:0048205)2.76178648
68Golgi transport vesicle coating (GO:0048200)2.76178648
69ethanol oxidation (GO:0006069)2.70820886
70cellular sodium ion homeostasis (GO:0006883)2.68372236
71white fat cell differentiation (GO:0050872)2.65822792
72regulation of endopeptidase activity (GO:0052548)2.64703892
73response to nitrosative stress (GO:0051409)2.64423941
74response to bacterium (GO:0009617)2.62815637
75negative regulation of glycogen biosynthetic process (GO:0045719)2.62485773
76pyrimidine ribonucleoside catabolic process (GO:0046133)2.62132684
77brown fat cell differentiation (GO:0050873)2.58681667
78high-density lipoprotein particle remodeling (GO:0034375)2.58146878
79negative regulation of endocytosis (GO:0045806)2.57667910
80regulation of antigen processing and presentation (GO:0002577)2.56114948
81serine transport (GO:0032329)2.55753707
82negative regulation of metanephros development (GO:0072217)2.53302928
83CDP-diacylglycerol biosynthetic process (GO:0016024)2.52901903
84regulation of peptidase activity (GO:0052547)2.51800158
85N-acetylneuraminate metabolic process (GO:0006054)2.43296473
86glycerolipid catabolic process (GO:0046503)2.42535099
87cellular modified amino acid catabolic process (GO:0042219)2.42051277
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41943618
89oxaloacetate metabolic process (GO:0006107)2.40558772
90regulation of complement activation (GO:0030449)2.39906024
91cytolysis (GO:0019835)2.39371740
92regulation of sterol transport (GO:0032371)2.33803703
93regulation of cholesterol transport (GO:0032374)2.33803703
94negative regulation of glycogen metabolic process (GO:0070874)2.32728172
95CDP-diacylglycerol metabolic process (GO:0046341)2.31982533
96positive regulation of glomerulus development (GO:0090193)2.31084117
97nerve growth factor signaling pathway (GO:0038180)2.29508784
98seminiferous tubule development (GO:0072520)19.0539366
99regulation of T cell tolerance induction (GO:0002664)10.9864967
100production of molecular mediator involved in inflammatory response (GO:0002532)10.7705117

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.15699062
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79661576
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.44718340
4AR_21572438_ChIP-Seq_LNCaP_Human3.41416968
5IKZF1_21737484_ChIP-ChIP_HCT116_Human3.29212544
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.10299260
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91602405
8ZNF263_19887448_ChIP-Seq_K562_Human2.90878221
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.41682336
10CLOCK_20551151_ChIP-Seq_293T_Human2.37240884
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.36054950
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.31317645
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.28832429
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.20539478
15DNAJC2_21179169_ChIP-ChIP_NT2_Human2.09880407
16SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse2.08069166
17PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79608039
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76534815
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75949081
20GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.70319022
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.69007871
22STAT1_17558387_ChIP-Seq_HELA_Human1.62930947
23SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56025404
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51418311
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50588801
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48579786
27CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47594528
28FLI1_21867929_ChIP-Seq_CD8_Mouse1.45671473
29GATA3_21867929_ChIP-Seq_TH1_Mouse1.44339653
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43118678
31NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.43058575
32P68_20966046_ChIP-Seq_HELA_Human1.42235029
33PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40672775
34RAD21_21589869_ChIP-Seq_MESCs_Mouse1.40344224
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.39139344
36LXR_22292898_ChIP-Seq_THP-1_Human1.39054274
37MYC_19915707_ChIP-ChIP_AK7_Human1.38878722
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35903469
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35410720
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35094259
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35094259
42VDR_24787735_ChIP-Seq_THP-1_Human1.33574471
43ELK4_26923725_Chip-Seq_MESODERM_Mouse1.29991031
44SOX2_22085726_ChIP-Seq_NPCs_Mouse1.23914497
45GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.21582133
46FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21309189
47BCOR_27268052_Chip-Seq_Bcells_Human1.18446591
48BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17603172
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15230697
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13571079
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13218222
52SMC4_20622854_ChIP-Seq_HELA_Human1.12899623
53FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12882631
54* SMAD4_21741376_ChIP-Seq_HESCs_Human1.11903176
55SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09066116
56CSB_26484114_Chip-Seq_FIBROBLAST_Human1.08182046
57RACK7_27058665_Chip-Seq_MCF-7_Human1.04887445
58MYC_27129775_Chip-Seq_CORNEA_Mouse1.04355325
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04265971
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04233496
61FOXH1_21741376_ChIP-Seq_ESCs_Human1.03235678
62OCT4_20526341_ChIP-Seq_ESCs_Human1.02672093
63SOX2_20726797_ChIP-Seq_SW620_Human0.99325728
64REST_19997604_ChIP-ChIP_NEURONS_Mouse0.99005769
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97887891
66JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97826967
67BCL6_27268052_Chip-Seq_Bcells_Human0.97498256
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97251768
69NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96610185
70ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96342308
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95880587
72SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94883865
73* ELF1_20517297_ChIP-Seq_JURKAT_Human0.94758344
74SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93377613
75E2F1_20622854_ChIP-Seq_HELA_Human0.92831956
76KDM2B_26808549_Chip-Seq_K562_Human0.92627358
77RAC3_21632823_ChIP-Seq_H3396_Human0.91070322
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89766239
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88343541
80CEBPB_22108803_ChIP-Seq_LS180_Human0.88295166
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86853703
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86003892
83MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85575907
84FOXO3_23340844_ChIP-Seq_DLD1_Human0.84936954
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84714692
86RARB_24833708_ChIP-Seq_LIVER_Mouse0.84398434
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83851000
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83706952
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82884885
90GATA1_19941826_ChIP-Seq_K562_Human0.81340341
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80748127
92IGF1R_20145208_ChIP-Seq_DFB_Human0.80313448
93KDM2B_26808549_Chip-Seq_REH_Human0.80108447
94SALL4_22934838_ChIP-ChIP_CD34+_Human0.78882696
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78684135
96HTT_18923047_ChIP-ChIP_STHdh_Human0.78584284
97SMAD4_21741376_ChIP-Seq_ESCs_Human0.76883370
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.76817994
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76755094
100GATA3_21867929_ChIP-Seq_CD8_Mouse0.75479253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.05198984
2MP0003195_calcinosis4.61644935
3MP0002139_abnormal_hepatobiliary_system4.35495107
4MP0002254_reproductive_system_inflammat4.18747879
5MP0003303_peritoneal_inflammation4.01447477
6MP0004043_abnormal_pH_regulation3.70727434
7MP0010234_abnormal_vibrissa_follicle3.31574790
8MP0005670_abnormal_white_adipose2.58066151
9MP0005410_abnormal_fertilization2.51691472
10MP0000003_abnormal_adipose_tissue2.49834645
11MP0010329_abnormal_lipoprotein_level2.42065448
12MP0004130_abnormal_muscle_cell2.28596279
13MP0005375_adipose_tissue_phenotype2.25340711
14MP0003329_amyloid_beta_deposits2.16430783
15MP0004185_abnormal_adipocyte_glucose2.04348568
16MP0005666_abnormal_adipose_tissue2.02781914
17MP0005365_abnormal_bile_salt1.97935348
18MP0003300_gastrointestinal_ulcer1.93821553
19MP0005360_urolithiasis1.87327723
20MP0003705_abnormal_hypodermis_morpholog1.86363338
21MP0001501_abnormal_sleep_pattern1.80535770
22MP0002837_dystrophic_cardiac_calcinosis1.77285387
23MP0008438_abnormal_cutaneous_collagen1.74248578
24MP0003566_abnormal_cell_adhesion1.72534580
25MP0002168_other_aberrant_phenotype1.71619243
26MP0003191_abnormal_cellular_cholesterol1.60600639
27MP0001765_abnormal_ion_homeostasis1.59780698
28MP0000604_amyloidosis1.59565015
29MP0009643_abnormal_urine_homeostasis1.53150131
30MP0002118_abnormal_lipid_homeostasis1.51798458
31MP0003690_abnormal_glial_cell1.49820495
32MP0005275_abnormal_skin_tensile1.42390884
33MP0002876_abnormal_thyroid_physiology1.40249335
34MP0001756_abnormal_urination1.38720686
35MP0004885_abnormal_endolymph1.34390507
36MP0004858_abnormal_nervous_system1.32782686
37MP0005332_abnormal_amino_acid1.31279467
38MP0001853_heart_inflammation1.30636434
39MP0003806_abnormal_nucleotide_metabolis1.29841125
40MP0005584_abnormal_enzyme/coenzyme_acti1.25369635
41MP0005085_abnormal_gallbladder_physiolo1.25280712
42MP0002796_impaired_skin_barrier1.19907890
43MP0005636_abnormal_mineral_homeostasis1.12739893
44MP0000534_abnormal_ureter_morphology1.10721525
45MP0002971_abnormal_brown_adipose1.10247070
46MP0009780_abnormal_chondrocyte_physiolo1.10041549
47MP0003075_altered_response_to1.07401558
48MP0005334_abnormal_fat_pad1.05750680
49MP0003252_abnormal_bile_duct1.03758994
50MP0000609_abnormal_liver_physiology1.01381756
51MP0001440_abnormal_grooming_behavior0.96541054
52MP0002136_abnormal_kidney_physiology0.96485627
53MP0000537_abnormal_urethra_morphology0.96380236
54MP0003879_abnormal_hair_cell0.94319618
55MP0002909_abnormal_adrenal_gland0.91134866
56MP0004272_abnormal_basement_membrane0.89322800
57MP0002138_abnormal_hepatobiliary_system0.89196048
58MP0005535_abnormal_body_temperature0.86349926
59MP0002896_abnormal_bone_mineralization0.86270456
60MP0008875_abnormal_xenobiotic_pharmacok0.86217415
61MP0002653_abnormal_ependyma_morphology0.84731843
62MP0009763_increased_sensitivity_to0.83059834
63MP0009115_abnormal_fat_cell0.82269580
64MP0003959_abnormal_lean_body0.81696504
65MP0000013_abnormal_adipose_tissue0.79236880
66MP0005319_abnormal_enzyme/_coenzyme0.78591741
67MP0003878_abnormal_ear_physiology0.76942460
68MP0005377_hearing/vestibular/ear_phenot0.76942460
69MP0001764_abnormal_homeostasis0.76864889
70MP0003698_abnormal_male_reproductive0.74016309
71MP0000751_myopathy0.73959661
72MP0001666_abnormal_nutrient_absorption0.72647678
73MP0004019_abnormal_vitamin_homeostasis0.72554084
74MP0003632_abnormal_nervous_system0.68966487
75MP0002970_abnormal_white_adipose0.68838271
76MP0002733_abnormal_thermal_nociception0.68811861
77MP0004264_abnormal_extraembryonic_tissu0.68212230
78MP0002089_abnormal_postnatal_growth/wei0.68137920
79MP0006138_congestive_heart_failure0.67475560
80MP0003656_abnormal_erythrocyte_physiolo0.66922845
81MP0004036_abnormal_muscle_relaxation0.66762776
82MP0000249_abnormal_blood_vessel0.65870839
83MP0002295_abnormal_pulmonary_circulatio0.64741339
84MP0009384_cardiac_valve_regurgitation0.63518960
85MP0004270_analgesia0.63066757
86MP0002933_joint_inflammation0.63020393
87MP0002078_abnormal_glucose_homeostasis0.62906302
88MP0003633_abnormal_nervous_system0.61155735
89MP0005164_abnormal_response_to0.60167033
90MP0004145_abnormal_muscle_electrophysio0.59783695
91MP0000920_abnormal_myelination0.59780424
92MP0001881_abnormal_mammary_gland0.59770542
93MP0008961_abnormal_basal_metabolism0.59230907
94MP0003045_fibrosis0.59070708
95MP0003631_nervous_system_phenotype0.59068706
96MP0004859_abnormal_synaptic_plasticity0.59050918
97MP0005083_abnormal_biliary_tract0.58650145
98MP0003186_abnormal_redox_activity0.58123288
99MP0003634_abnormal_glial_cell0.57171436
100MP0000747_muscle_weakness0.55906757

Predicted human phenotypes

RankGene SetZ-score
1Choroideremia (HP:0001139)7.06697007
2Complement deficiency (HP:0004431)6.12955864
3Abnormality of the fovea (HP:0000493)6.05379065
4Abnormal rod and cone electroretinograms (HP:0008323)5.36964356
5Facial shape deformation (HP:0011334)4.97466164
6Potter facies (HP:0002009)4.97466164
7Vacuolated lymphocytes (HP:0001922)4.94060686
8Vascular calcification (HP:0004934)4.68827960
9Myocardial infarction (HP:0001658)4.58075198
10Bony spicule pigmentary retinopathy (HP:0007737)4.57817650
11Abnormality of complement system (HP:0005339)4.41375557
12Cardiovascular calcification (HP:0011915)4.34615862
13Neurofibrillary tangles (HP:0002185)4.29719072
14Recurrent gram-negative bacterial infections (HP:0005420)4.18527565
15Hypopigmentation of the fundus (HP:0007894)4.17287088
16Hypophosphatemic rickets (HP:0004912)4.11117367
17Cerebral inclusion bodies (HP:0100314)4.04890675
18Intention tremor (HP:0002080)3.63269053
19Infantile muscular hypotonia (HP:0008947)3.29389307
20Metaphyseal cupping (HP:0003021)3.19475268
21Action tremor (HP:0002345)3.11751883
22Hand muscle atrophy (HP:0009130)3.07777041
23Hyperglycinuria (HP:0003108)3.07222901
24Supranuclear gaze palsy (HP:0000605)2.95865230
25Neoplasm of the heart (HP:0100544)2.95766018
26Agitation (HP:0000713)2.95174688
27Hyperphosphatemia (HP:0002905)2.87186433
28Hemiplegia (HP:0002301)2.83489283
29Dysostosis multiplex (HP:0000943)2.80200330
30Malnutrition (HP:0004395)2.77671132
31Stridor (HP:0010307)2.70749722
32Upper limb amyotrophy (HP:0009129)2.66832989
33Distal upper limb amyotrophy (HP:0007149)2.66832989
34Acanthosis nigricans (HP:0000956)2.64495803
35Abnormality of serine family amino acid metabolism (HP:0010894)2.62243180
36Abnormality of glycine metabolism (HP:0010895)2.62243180
37Ketoacidosis (HP:0001993)2.60376516
38Oligomenorrhea (HP:0000876)2.59186230
39Polar cataract (HP:0010696)2.55421286
40Hyperglycinemia (HP:0002154)2.52515291
41Rickets (HP:0002748)2.51858083
42Hypertriglyceridemia (HP:0002155)2.44388230
43Facial diplegia (HP:0001349)2.43940742
4411 pairs of ribs (HP:0000878)2.42403675
45Diaphragmatic weakness (HP:0009113)2.39383834
46Xanthomatosis (HP:0000991)2.34127133
47Hemorrhage of the eye (HP:0011885)2.30203811
48Tubulointerstitial fibrosis (HP:0005576)2.25502347
49Abnormal hemoglobin (HP:0011902)2.23983950
50Subcapsular cataract (HP:0000523)2.21591791
51Ketosis (HP:0001946)2.20496560
52Focal segmental glomerulosclerosis (HP:0000097)2.20482827
53Widely patent fontanelles and sutures (HP:0004492)2.19846093
54Skin nodule (HP:0200036)2.19839657
55Abnormality of purine metabolism (HP:0004352)2.16920977
56Deep venous thrombosis (HP:0002625)2.15008081
57Abnormality of macular pigmentation (HP:0008002)2.10865908
58Loss of speech (HP:0002371)2.09266967
59Restlessness (HP:0000711)2.09066527
60Osteomalacia (HP:0002749)2.08673768
61Missing ribs (HP:0000921)2.08417642
62Choreoathetosis (HP:0001266)2.06541515
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.05877803
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05877803
65Ectopia lentis (HP:0001083)2.05664446
66Difficulty running (HP:0009046)2.04448323
67Systemic lupus erythematosus (HP:0002725)2.03807544
68Mucopolysacchariduria (HP:0008155)1.97680146
69Urinary glycosaminoglycan excretion (HP:0003541)1.97680146
70Clumsiness (HP:0002312)1.96005586
71Abnormality of macrophages (HP:0004311)1.91464505
72Ankle clonus (HP:0011448)1.90144959
73Muscle fiber splitting (HP:0003555)1.84254854
74Glomerulosclerosis (HP:0000096)1.83296594
75Central scotoma (HP:0000603)1.82418221
76Thin bony cortex (HP:0002753)1.82237084
77Abnormality of the calcaneus (HP:0008364)1.78952233
78Abnormality of polysaccharide metabolism (HP:0011012)1.78907738
79Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78907738
80Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78907738
81Hyporeflexia of lower limbs (HP:0002600)1.78750649
82Gout (HP:0001997)1.78568456
83Testicular atrophy (HP:0000029)1.77581698
84Pseudobulbar signs (HP:0002200)1.73710110
85Hyperammonemia (HP:0001987)1.73146028
86Progressive neurologic deterioration (HP:0002344)1.73036423
87Epidermoid cyst (HP:0200040)1.72569550
88Right ventricular cardiomyopathy (HP:0011663)1.72404121
89Hyperparathyroidism (HP:0000843)1.70876859
90Cardiomegaly (HP:0001640)1.69164577
91Abnormality of sulfur amino acid metabolism (HP:0004339)1.69112669
92Abnormality of the lumbar spine (HP:0100712)1.68756353
93Back pain (HP:0003418)1.65705047
94Hypoventilation (HP:0002791)1.64471087
95Hypophosphatemia (HP:0002148)1.64368495
96Intrahepatic cholestasis (HP:0001406)1.62987279
97Mutism (HP:0002300)1.61614504
98Macular degeneration (HP:0000608)1.61523335
99Growth hormone excess (HP:0000845)1.61450538
100Proximal tubulopathy (HP:0000114)1.58947109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.50148661
2ERN13.43698861
3LMTK23.36514769
4TRIB33.27047210
5TAOK33.00519092
6MST42.83821881
7PKN22.71185455
8WNK42.59374277
9EPHB12.35833329
10LRRK22.15219792
11PDGFRA2.01496298
12MYLK1.96044516
13FER1.84382933
14PRKD31.82064820
15FGFR21.74359047
16RIPK41.58461805
17FGFR41.54055826
18TTN1.47984292
19BCKDK1.43456968
20RET1.41265377
21FRK1.37187275
22MAP2K41.30097828
23PTK21.26822792
24PTK61.25185414
25PAK31.24767033
26STK391.23357818
27MAP3K21.19596071
28TNK21.16912915
29NTRK11.13759862
30PTK2B1.13467662
31RIPK11.10499289
32CAMK1G1.04927759
33WNK11.04749857
34CAMK1D1.04372659
35LATS11.01181036
36PRKCH1.00972495
37PAK21.00207548
38EPHB20.98376447
39FLT30.98039502
40DDR20.96647154
41BMX0.96620287
42TYRO30.96135759
43INSR0.91457250
44LATS20.89803504
45CDK190.89549547
46KSR20.88449997
47TESK10.86787129
48MAP3K60.86559959
49DMPK0.84740323
50PAK60.83677416
51INSRR0.83413244
52FGFR30.81236095
53PDK30.78785271
54PDK40.78785271
55STK380.77685904
56EEF2K0.76546451
57ICK0.76474977
58PHKG10.76085081
59PHKG20.76085081
60JAK20.76021787
61SIK20.74089555
62NTRK30.73712131
63MAP3K40.72392609
64MAP2K10.71943121
65STK100.70182583
66SCYL20.65768351
67PRKCZ0.65414392
68PAK40.64945989
69SRC0.64263425
70MET0.63490311
71EGFR0.62384635
72STK38L0.61489801
73PRKCG0.61472785
74IRAK20.60913445
75PDGFRB0.59123913
76CDK50.58594742
77IRAK30.58463629
78GSK3A0.58387423
79MAP3K70.58374459
80FYN0.57563796
81AKT30.55380666
82ILK0.54745629
83MAP3K120.54359519
84ERBB20.53633217
85PRKD10.53260448
86EPHA20.52746533
87FGFR10.50934588
88PRKACG0.50380887
89MST1R0.48845202
90GRK60.48767114
91PDK20.47716201
92GRK50.46361436
93CDK60.46128556
94ALK0.44635584
95DAPK20.44155437
96JAK10.42800548
97PDK10.42010992
98PDPK10.41643924
99CSNK1E0.41162057
100MINK10.39213633

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.43998368
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.59793266
3Glutathione metabolism_Homo sapiens_hsa004803.40622516
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.00814929
5Thyroid hormone synthesis_Homo sapiens_hsa049182.77013238
6Tryptophan metabolism_Homo sapiens_hsa003802.74239187
7Arachidonic acid metabolism_Homo sapiens_hsa005902.72808862
8Sulfur metabolism_Homo sapiens_hsa009202.55008685
9Fatty acid metabolism_Homo sapiens_hsa012122.37342860
10Fatty acid degradation_Homo sapiens_hsa000712.33512204
11PPAR signaling pathway_Homo sapiens_hsa033202.28453304
12African trypanosomiasis_Homo sapiens_hsa051432.27113192
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98098159
14Glycerolipid metabolism_Homo sapiens_hsa005611.92823413
15Arginine biosynthesis_Homo sapiens_hsa002201.74878301
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.74494800
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71232960
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55546647
19ABC transporters_Homo sapiens_hsa020101.50145469
20Propanoate metabolism_Homo sapiens_hsa006401.46566699
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46523672
22Salivary secretion_Homo sapiens_hsa049701.45066323
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36945819
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36186603
25Phenylalanine metabolism_Homo sapiens_hsa003601.30553339
26Lysosome_Homo sapiens_hsa041421.29345697
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.27239866
28Other glycan degradation_Homo sapiens_hsa005111.25577788
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24820524
30Fat digestion and absorption_Homo sapiens_hsa049751.21824228
31Complement and coagulation cascades_Homo sapiens_hsa046101.20979440
32beta-Alanine metabolism_Homo sapiens_hsa004101.15133107
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14667148
34Renin secretion_Homo sapiens_hsa049241.05393172
35Vitamin B6 metabolism_Homo sapiens_hsa007501.03386524
36Pyruvate metabolism_Homo sapiens_hsa006201.02663840
37Tyrosine metabolism_Homo sapiens_hsa003501.02590435
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02578463
39Prion diseases_Homo sapiens_hsa050200.98482200
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95177538
41Fatty acid biosynthesis_Homo sapiens_hsa000610.95121207
42Butanoate metabolism_Homo sapiens_hsa006500.90162564
43Carbon metabolism_Homo sapiens_hsa012000.89683039
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87344892
45Gastric acid secretion_Homo sapiens_hsa049710.84862784
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84551194
47Bile secretion_Homo sapiens_hsa049760.82593798
48Staphylococcus aureus infection_Homo sapiens_hsa051500.81925819
49Collecting duct acid secretion_Homo sapiens_hsa049660.75175201
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73398117
51Starch and sucrose metabolism_Homo sapiens_hsa005000.73151540
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71409834
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68685755
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68549766
55Chemical carcinogenesis_Homo sapiens_hsa052040.66479202
56Biosynthesis of amino acids_Homo sapiens_hsa012300.66042118
57Estrogen signaling pathway_Homo sapiens_hsa049150.65674473
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65139430
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64453377
60Vibrio cholerae infection_Homo sapiens_hsa051100.63802470
61Peroxisome_Homo sapiens_hsa041460.63801995
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.61195550
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54938018
64GABAergic synapse_Homo sapiens_hsa047270.54866984
65Fatty acid elongation_Homo sapiens_hsa000620.50564904
66Long-term potentiation_Homo sapiens_hsa047200.49532629
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.48533387
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48251189
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45551219
70Arginine and proline metabolism_Homo sapiens_hsa003300.45438228
71Circadian entrainment_Homo sapiens_hsa047130.44120183
72Histidine metabolism_Homo sapiens_hsa003400.42232792
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42098685
74AMPK signaling pathway_Homo sapiens_hsa041520.40648588
75Insulin resistance_Homo sapiens_hsa049310.38170333
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.37090830
77Synaptic vesicle cycle_Homo sapiens_hsa047210.36578761
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35468144
79cAMP signaling pathway_Homo sapiens_hsa040240.34531008
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34509321
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.34220648
82Protein digestion and absorption_Homo sapiens_hsa049740.33023350
83Glucagon signaling pathway_Homo sapiens_hsa049220.31690374
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31324230
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.31309981
86Type II diabetes mellitus_Homo sapiens_hsa049300.29773525
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28847585
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26861805
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25892503
90Insulin secretion_Homo sapiens_hsa049110.24923353
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.21620364
92Pancreatic secretion_Homo sapiens_hsa049720.21605367
93Amphetamine addiction_Homo sapiens_hsa050310.21133544
94GnRH signaling pathway_Homo sapiens_hsa049120.21033103
95Ovarian steroidogenesis_Homo sapiens_hsa049130.20879465
96N-Glycan biosynthesis_Homo sapiens_hsa005100.20001440
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19996431
98Glutamatergic synapse_Homo sapiens_hsa047240.18988557
99Melanogenesis_Homo sapiens_hsa049160.18934507
100Calcium signaling pathway_Homo sapiens_hsa040200.17888927

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