RNASE13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.36738688
2tryptophan catabolic process (GO:0006569)9.02768124
3indole-containing compound catabolic process (GO:0042436)9.02768124
4indolalkylamine catabolic process (GO:0046218)9.02768124
5regulation of tolerance induction (GO:0002643)8.74463934
6tryptophan metabolic process (GO:0006568)7.89517711
7regulation of chronic inflammatory response (GO:0002676)7.42665405
8single fertilization (GO:0007338)7.14468122
9heterotypic cell-cell adhesion (GO:0034113)6.93967625
10aromatic amino acid family catabolic process (GO:0009074)6.88651094
11positive regulation of type 2 immune response (GO:0002830)6.09307840
12negative regulation of interleukin-10 production (GO:0032693)5.97323814
13amine catabolic process (GO:0009310)5.92469214
14cellular biogenic amine catabolic process (GO:0042402)5.92469214
15indolalkylamine metabolic process (GO:0006586)5.82325724
16benzene-containing compound metabolic process (GO:0042537)5.21190293
17aromatic amino acid family metabolic process (GO:0009072)5.00215798
18fertilization (GO:0009566)4.68256025
19sulfur amino acid catabolic process (GO:0000098)4.49490937
20reverse cholesterol transport (GO:0043691)4.27031553
21negative regulation of interleukin-8 production (GO:0032717)4.19793292
22alpha-linolenic acid metabolic process (GO:0036109)4.18405376
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.16926650
24indole-containing compound metabolic process (GO:0042430)4.08103878
25L-phenylalanine catabolic process (GO:0006559)3.95754590
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.95754590
27digestion (GO:0007586)3.91980783
28complement activation, alternative pathway (GO:0006957)3.88480404
29negative regulation of endopeptidase activity (GO:0010951)3.85964021
30cysteine metabolic process (GO:0006534)3.84155194
31negative regulation of T cell apoptotic process (GO:0070233)3.72705600
32negative regulation of peptidase activity (GO:0010466)3.68457562
33phospholipid homeostasis (GO:0055091)3.66911559
34positive regulation of cell-cell adhesion (GO:0022409)3.65118819
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.64910243
36L-phenylalanine metabolic process (GO:0006558)3.64910243
37transepithelial transport (GO:0070633)3.59940372
38epithelial cell morphogenesis (GO:0003382)3.59725912
39high-density lipoprotein particle remodeling (GO:0034375)3.59404331
40alpha-amino acid catabolic process (GO:1901606)3.33415291
41cellular amino acid catabolic process (GO:0009063)3.17094726
42regulation of type 2 immune response (GO:0002828)3.13903066
43N-acetylneuraminate metabolic process (GO:0006054)3.02751904
44negative regulation of protein autophosphorylation (GO:0031953)3.02239310
45seminiferous tubule development (GO:0072520)20.7778898
46valine metabolic process (GO:0006573)2.98977856
47regulation of lipoprotein metabolic process (GO:0050746)2.98749134
48plasma lipoprotein particle remodeling (GO:0034369)2.97107992
49protein-lipid complex remodeling (GO:0034368)2.97107992
50macromolecular complex remodeling (GO:0034367)2.97107992
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95829412
52defense response to bacterium (GO:0042742)2.95803927
53regulation of clathrin-mediated endocytosis (GO:2000369)2.95563899
54regulation of protein activation cascade (GO:2000257)2.91292782
55glutamate metabolic process (GO:0006536)2.90405540
56ethanol oxidation (GO:0006069)2.87236416
57regulation of complement activation (GO:0030449)2.85237652
58cellular modified amino acid catabolic process (GO:0042219)2.84292091
59bile acid biosynthetic process (GO:0006699)2.76325102
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.72157915
61hormone catabolic process (GO:0042447)2.70244811
62negative regulation of fibrinolysis (GO:0051918)2.63862866
63dicarboxylic acid biosynthetic process (GO:0043650)2.63730066
64regulation of macrophage activation (GO:0043030)2.63604309
65glyoxylate metabolic process (GO:0046487)2.62492839
66organic acid catabolic process (GO:0016054)2.61615975
67carboxylic acid catabolic process (GO:0046395)2.61615975
68regulation of triglyceride catabolic process (GO:0010896)2.59401292
69response to bacterium (GO:0009617)2.56567455
70low-density lipoprotein particle clearance (GO:0034383)2.55747474
71lysine catabolic process (GO:0006554)2.54680315
72lysine metabolic process (GO:0006553)2.54680315
73fatty acid beta-oxidation (GO:0006635)2.54396512
74serine family amino acid catabolic process (GO:0009071)2.53621079
75complement activation, classical pathway (GO:0006958)2.52559059
762-oxoglutarate metabolic process (GO:0006103)2.50526510
77aspartate family amino acid catabolic process (GO:0009068)2.49951730
78plasma lipoprotein particle clearance (GO:0034381)2.49496780
79negative regulation of proteolysis (GO:0045861)2.46487864
80complement activation (GO:0006956)2.46094545
81triglyceride catabolic process (GO:0019433)2.44872816
82neutral lipid catabolic process (GO:0046461)2.43188681
83acylglycerol catabolic process (GO:0046464)2.43188681
84cytolysis (GO:0019835)2.40779488
85regulation of fibrinolysis (GO:0051917)2.39325836
86negative regulation of protein maturation (GO:1903318)2.38970656
87negative regulation of protein processing (GO:0010955)2.38970656
88peptidyl-glutamic acid carboxylation (GO:0017187)2.38916482
89protein carboxylation (GO:0018214)2.38916482
90urea metabolic process (GO:0019627)2.38614622
91urea cycle (GO:0000050)2.38614622
92sialylation (GO:0097503)2.37906918
93fatty acid oxidation (GO:0019395)2.37761518
94negative regulation of lipase activity (GO:0060192)2.37609543
95fatty acid catabolic process (GO:0009062)2.37576700
96lipid catabolic process (GO:0016042)2.37504012
97production of molecular mediator involved in inflammatory response (GO:0002532)11.9926842
98regulation of T cell tolerance induction (GO:0002664)11.7864837
99kynurenine metabolic process (GO:0070189)10.6025339
100positive regulation of tolerance induction (GO:0002645)10.0758492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.03846819
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.09191641
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01349762
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.80034035
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.40741177
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.36751454
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.30249465
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.21701805
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.98277647
10AR_21572438_ChIP-Seq_LNCaP_Human2.91746952
11ZNF263_19887448_ChIP-Seq_K562_Human2.40705388
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.35497181
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.33287665
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.07886057
15CLOCK_20551151_ChIP-Seq_293T_Human2.02716355
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.01716383
17DNAJC2_21179169_ChIP-ChIP_NT2_Human1.97169999
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96474839
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.89801489
20SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.86441876
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80883779
22GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.64168732
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61884286
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.60861224
25GATA3_21867929_ChIP-Seq_TH1_Mouse1.58129666
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58060063
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54997842
28NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.50874643
29SMAD1_18555785_Chip-Seq_ESCs_Mouse1.48184757
30PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47455484
31RAD21_21589869_ChIP-Seq_MESCs_Mouse1.46079237
32STAT1_17558387_ChIP-Seq_HELA_Human1.44528761
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.43436724
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42307148
35SMAD4_21741376_ChIP-Seq_HESCs_Human1.37551420
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37258052
37FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34777955
38FLI1_21867929_ChIP-Seq_CD8_Mouse1.34415591
39REST_19997604_ChIP-ChIP_NEURONS_Mouse1.33532330
40SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30927163
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28185519
42ESRRB_18555785_Chip-Seq_ESCs_Mouse1.24278019
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21929853
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21929853
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19454849
46HTT_18923047_ChIP-ChIP_STHdh_Human1.13992584
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13845992
48* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13694182
49SMAD3_21741376_ChIP-Seq_HESCs_Human1.12838787
50CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12623828
51GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11322217
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09687620
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.09396918
54P68_20966046_ChIP-Seq_HELA_Human1.09207995
55BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07830837
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.06700162
57JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04265876
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03680527
59CTCF_18555785_Chip-Seq_ESCs_Mouse1.03459445
60MYC_19915707_ChIP-ChIP_AK7_Human1.02513302
61RACK7_27058665_Chip-Seq_MCF-7_Human1.02258986
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01084502
63SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99936777
64SMC4_20622854_ChIP-Seq_HELA_Human0.99311792
65FOXH1_21741376_ChIP-Seq_ESCs_Human0.95904390
66VDR_24787735_ChIP-Seq_THP-1_Human0.95511403
67SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94851148
68BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.94279335
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94166444
70EZH2_27294783_Chip-Seq_NPCs_Mouse0.93686500
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92525811
72ERG_21242973_ChIP-ChIP_JURKAT_Human0.91944172
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91830217
74NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90458188
75FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89930454
76BCL6_27268052_Chip-Seq_Bcells_Human0.89384925
77MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88797430
78* MYC_27129775_Chip-Seq_CORNEA_Mouse0.86786304
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86625962
80KDM2B_26808549_Chip-Seq_REH_Human0.85704893
81CBX2_27304074_Chip-Seq_ESCs_Mouse0.85448210
82ETS1_21867929_ChIP-Seq_TH2_Mouse0.85195539
83LXR_22292898_ChIP-Seq_THP-1_Human0.84888090
84EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84504343
85RARA_24833708_ChIP-Seq_LIVER_Mouse0.84339818
86OCT4_20526341_ChIP-Seq_ESCs_Human0.84123178
87REST_18959480_ChIP-ChIP_MESCs_Mouse0.83732316
88RAC3_21632823_ChIP-Seq_H3396_Human0.82847905
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.82111407
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81542054
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81291499
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81241404
93BCOR_27268052_Chip-Seq_Bcells_Human0.80293980
94RUNX1_27457419_Chip-Seq_LIVER_Mouse0.79276809
95DROSHA_22980978_ChIP-Seq_HELA_Human0.78953102
96RARB_24833708_ChIP-Seq_LIVER_Mouse0.78776133
97GATA1_19941826_ChIP-Seq_K562_Human0.78731812
98P300_27268052_Chip-Seq_Bcells_Human0.78523996
99NANOG_20526341_ChIP-Seq_ESCs_Human0.78315780
100ELK4_26923725_Chip-Seq_MESODERM_Mouse0.77781643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.20542335
2MP0003195_calcinosis4.90694295
3MP0005360_urolithiasis4.29024477
4MP0003303_peritoneal_inflammation4.12499684
5MP0002254_reproductive_system_inflammat3.96630695
6MP0004043_abnormal_pH_regulation3.67317526
7MP0005365_abnormal_bile_salt3.63669771
8MP0005085_abnormal_gallbladder_physiolo3.62239481
9MP0010234_abnormal_vibrissa_follicle2.92706225
10MP0010329_abnormal_lipoprotein_level2.86336303
11MP0003806_abnormal_nucleotide_metabolis2.58952389
12MP0008875_abnormal_xenobiotic_pharmacok2.48399145
13MP0003329_amyloid_beta_deposits2.45442120
14MP0005058_abnormal_lysosome_morphology2.38548665
15MP0005410_abnormal_fertilization2.35532159
16MP0003252_abnormal_bile_duct2.22851087
17MP0004145_abnormal_muscle_electrophysio2.10553805
18MP0004130_abnormal_muscle_cell2.06975960
19MP0005083_abnormal_biliary_tract2.06612115
20MP0005332_abnormal_amino_acid2.00225407
21MP0000604_amyloidosis1.81846015
22MP0002837_dystrophic_cardiac_calcinosis1.78642272
23MP0002118_abnormal_lipid_homeostasis1.73709252
24MP0009840_abnormal_foam_cell1.67458698
25MP0003191_abnormal_cellular_cholesterol1.59660842
26MP0000003_abnormal_adipose_tissue1.54196746
27MP0002168_other_aberrant_phenotype1.52178254
28MP0005584_abnormal_enzyme/coenzyme_acti1.51563520
29MP0001666_abnormal_nutrient_absorption1.41583173
30MP0009643_abnormal_urine_homeostasis1.41469615
31MP0000747_muscle_weakness1.41288002
32MP0000609_abnormal_liver_physiology1.38633929
33MP0003705_abnormal_hypodermis_morpholog1.30727757
34MP0005375_adipose_tissue_phenotype1.28336265
35MP0005319_abnormal_enzyme/_coenzyme1.28216410
36MP0003690_abnormal_glial_cell1.24599693
37MP0004185_abnormal_adipocyte_glucose1.22817018
38MP0001765_abnormal_ion_homeostasis1.22743842
39MP0004885_abnormal_endolymph1.22010758
40MP0001853_heart_inflammation1.21800305
41MP0004036_abnormal_muscle_relaxation1.20812414
42MP0003300_gastrointestinal_ulcer1.18298975
43MP0005636_abnormal_mineral_homeostasis1.11135424
44MP0000751_myopathy1.09374994
45MP0001501_abnormal_sleep_pattern1.08648623
46MP0000749_muscle_degeneration1.08599069
47MP0005666_abnormal_adipose_tissue1.06633482
48MP0001756_abnormal_urination1.04811187
49MP0001440_abnormal_grooming_behavior1.04014487
50MP0002138_abnormal_hepatobiliary_system1.01442051
51MP0003566_abnormal_cell_adhesion0.98673215
52MP0002971_abnormal_brown_adipose0.98055733
53MP0003656_abnormal_erythrocyte_physiolo0.94258858
54MP0004019_abnormal_vitamin_homeostasis0.93015090
55MP0002796_impaired_skin_barrier0.91992531
56MP0005670_abnormal_white_adipose0.90352228
57MP0004270_analgesia0.88988042
58MP0002876_abnormal_thyroid_physiology0.86041470
59MP0005334_abnormal_fat_pad0.83657752
60MP0004087_abnormal_muscle_fiber0.82606947
61MP0000534_abnormal_ureter_morphology0.80663252
62MP0003075_altered_response_to0.80421801
63MP0002089_abnormal_postnatal_growth/wei0.80246139
64MP0002269_muscular_atrophy0.79947267
65MP0005535_abnormal_body_temperature0.79833255
66MP0001764_abnormal_homeostasis0.79193011
67MP0005620_abnormal_muscle_contractility0.78761179
68MP0002896_abnormal_bone_mineralization0.78493570
69MP0004858_abnormal_nervous_system0.76085989
70MP0005275_abnormal_skin_tensile0.71653597
71MP0004859_abnormal_synaptic_plasticity0.70884891
72MP0002078_abnormal_glucose_homeostasis0.70759693
73MP0003632_abnormal_nervous_system0.70222600
74MP0002136_abnormal_kidney_physiology0.67946273
75MP0000920_abnormal_myelination0.66719951
76MP0003868_abnormal_feces_composition0.65763566
77MP0005395_other_phenotype0.63143822
78MP0000759_abnormal_skeletal_muscle0.62670315
79MP0009780_abnormal_chondrocyte_physiolo0.62002279
80MP0009384_cardiac_valve_regurgitation0.61943467
81MP0003879_abnormal_hair_cell0.59879878
82MP0008438_abnormal_cutaneous_collagen0.59269225
83MP0003959_abnormal_lean_body0.58221034
84MP0003631_nervous_system_phenotype0.57663898
85MP0002909_abnormal_adrenal_gland0.57004839
86MP0009764_decreased_sensitivity_to0.56933984
87MP0009763_increased_sensitivity_to0.56712667
88MP0005166_decreased_susceptibility_to0.56246616
89MP0003633_abnormal_nervous_system0.56232783
90MP0000750_abnormal_muscle_regeneration0.55958821
91MP0000598_abnormal_liver_morphology0.55707396
92MP0003698_abnormal_male_reproductive0.55518713
93MP0009642_abnormal_blood_homeostasis0.55469379
94MP0006036_abnormal_mitochondrial_physio0.54083915
95MP0010678_abnormal_skin_adnexa0.52356480
96MP0005330_cardiomyopathy0.52338364
97MP0000537_abnormal_urethra_morphology0.52259271
98MP0000249_abnormal_blood_vessel0.51956121
99MP0005408_hypopigmentation0.49321444
100MP0003646_muscle_fatigue0.47781115

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)5.56609293
2Myocardial infarction (HP:0001658)4.88946709
3Deep venous thrombosis (HP:0002625)4.67639079
4Xanthomatosis (HP:0000991)4.48940455
5Intrahepatic cholestasis (HP:0001406)4.43372157
6Hypophosphatemic rickets (HP:0004912)4.28536566
7Vascular calcification (HP:0004934)4.23178927
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.18427427
9Abnormality of complement system (HP:0005339)3.98684132
10Cardiovascular calcification (HP:0011915)3.87847235
11Malnutrition (HP:0004395)3.71903274
12Potter facies (HP:0002009)3.68650284
13Facial shape deformation (HP:0011334)3.68650284
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.49056398
15Ketosis (HP:0001946)3.47961126
16Hyperlipoproteinemia (HP:0010980)3.43636611
17Neurofibrillary tangles (HP:0002185)3.38358033
18Hyperglycinuria (HP:0003108)3.32817017
19Recurrent gram-negative bacterial infections (HP:0005420)3.29811434
20Cerebral inclusion bodies (HP:0100314)3.23575093
21Hyperglycinemia (HP:0002154)3.16215224
22Exercise-induced myalgia (HP:0003738)3.15049257
23Gout (HP:0001997)3.14973015
24Ketoacidosis (HP:0001993)3.13526626
25Hypoalphalipoproteinemia (HP:0003233)3.11871642
26Abnormality of serine family amino acid metabolism (HP:0010894)3.11690054
27Abnormality of glycine metabolism (HP:0010895)3.11690054
28Hyperammonemia (HP:0001987)3.03482912
29Exercise-induced muscle cramps (HP:0003710)3.02355874
30Difficulty running (HP:0009046)3.01806663
31Epidermoid cyst (HP:0200040)3.00664658
32Hypobetalipoproteinemia (HP:0003563)2.96659196
33Abnormality of purine metabolism (HP:0004352)2.87687900
34Rickets (HP:0002748)2.87473512
35Hypolipoproteinemia (HP:0010981)2.85968663
36Prolonged partial thromboplastin time (HP:0003645)2.82861577
37Muscle hypertrophy of the lower extremities (HP:0008968)2.82161203
38Hyporeflexia of lower limbs (HP:0002600)2.75790451
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.72159100
40Calf muscle hypertrophy (HP:0008981)2.68284392
41Myoglobinuria (HP:0002913)2.66393686
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.63441544
43Muscle fiber splitting (HP:0003555)2.62173646
44Infantile muscular hypotonia (HP:0008947)2.61297704
45Skin nodule (HP:0200036)2.54958716
46Choroideremia (HP:0001139)2.53750719
47Abnormality of the common coagulation pathway (HP:0010990)2.43588086
48Widely patent fontanelles and sutures (HP:0004492)2.40613868
49Choreoathetosis (HP:0001266)2.40082178
50Intention tremor (HP:0002080)2.39535809
51Hemorrhage of the eye (HP:0011885)2.38529961
52Hypoglycemic coma (HP:0001325)2.36904770
53Systemic lupus erythematosus (HP:0002725)2.35643915
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33527164
55Neoplasm of the heart (HP:0100544)2.30719882
56Increased connective tissue (HP:0009025)2.30586849
57Spastic diplegia (HP:0001264)2.23346549
58Agitation (HP:0000713)2.20191206
59Hypercholesterolemia (HP:0003124)2.16019031
60Cholelithiasis (HP:0001081)2.15790248
61Abnormal gallbladder morphology (HP:0012437)2.13771041
62Abnormality of nucleobase metabolism (HP:0010932)2.12483096
63Supranuclear gaze palsy (HP:0000605)2.11609547
64Abnormality of the Achilles tendon (HP:0005109)2.05378252
65Polar cataract (HP:0010696)2.04183951
66Muscle stiffness (HP:0003552)2.03960231
67Fat malabsorption (HP:0002630)2.03723834
68EMG: myopathic abnormalities (HP:0003458)2.02231104
69Acanthosis nigricans (HP:0000956)2.01644576
70Abnormality of fatty-acid metabolism (HP:0004359)1.99880220
71Hypertriglyceridemia (HP:0002155)1.97484261
72Testicular atrophy (HP:0000029)1.96199244
73Neonatal onset (HP:0003623)1.94864103
74Increased purine levels (HP:0004368)1.94689787
75Hyperuricemia (HP:0002149)1.94689787
76Joint hemorrhage (HP:0005261)1.93587877
77Abnormality of the intrinsic pathway (HP:0010989)1.93200124
78Oligomenorrhea (HP:0000876)1.93117772
79Hemiplegia (HP:0002301)1.90659585
80Amyloidosis (HP:0011034)1.90486350
81Abnormality of transition element cation homeostasis (HP:0011030)1.88142166
82Pancreatitis (HP:0001733)1.87912887
83Muscle fiber inclusion bodies (HP:0100299)1.87733343
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86710926
85Hyperbilirubinemia (HP:0002904)1.86675140
86Late onset (HP:0003584)1.85638725
87Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.81739721
88Delayed CNS myelination (HP:0002188)1.80110693
89Hepatocellular carcinoma (HP:0001402)1.79214180
90Spontaneous abortion (HP:0005268)1.79158356
91Abnormal gallbladder physiology (HP:0012438)1.78842230
92Cholecystitis (HP:0001082)1.78842230
93Asymmetric septal hypertrophy (HP:0001670)1.76345475
94Sensorimotor neuropathy (HP:0007141)1.72885310
95Myotonia (HP:0002486)1.72590947
96Increased variability in muscle fiber diameter (HP:0003557)1.72457963
97Focal segmental glomerulosclerosis (HP:0000097)1.71483037
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71445111
99Right ventricular cardiomyopathy (HP:0011663)1.71076596
100Abnormal enzyme/coenzyme activity (HP:0012379)1.70032626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.74716920
2SIK13.19023832
3BCKDK2.79326686
4EPHB12.79236256
5MST42.79181760
6FGFR42.54547760
7LMTK22.49539895
8TTN2.45259649
9TRIB32.35019375
10PKN22.24331003
11TAOK32.19012783
12FGFR22.14118890
13PHKG12.09356938
14PHKG22.09356938
15LRRK21.89320851
16MAP2K41.89065935
17FER1.80954272
18PDGFRA1.79215992
19MAP3K71.58462363
20PTK61.55371112
21STK391.52820514
22WNK41.35020090
23PDK31.32846839
24PDK41.32846839
25OBSCN1.22300977
26TNK21.21241170
27MAP3K21.19902911
28RET1.14009737
29PRKD31.13091841
30PAK31.09808018
31EPHA21.07669050
32PIK3CG1.06641549
33PTK2B1.05281487
34PTK21.00661616
35NTRK10.98352879
36KSR20.97325545
37MYLK0.96639413
38TYRO30.95872825
39DMPK0.95008560
40INSRR0.93608852
41INSR0.91862114
42PAK60.87575920
43PRKCH0.87152686
44FGFR30.85137972
45MAP3K60.83661644
46NTRK30.81327938
47FRK0.80874028
48JAK20.80312009
49MAPK120.79993466
50GSK3A0.78601392
51PRKCG0.77598688
52STK100.76132326
53ERBB40.75747015
54CDK190.72591554
55CAMK1G0.72266960
56MAP2K10.71884695
57EPHA40.71730686
58DAPK20.70337684
59ICK0.70163048
60LATS10.69166393
61LATS20.67658467
62PRKACG0.66454864
63RIPK40.66395323
64PDK20.63932060
65EPHB20.63585310
66MST1R0.62425329
67PAK20.62099118
68PINK10.60942873
69PRKCZ0.60091386
70FLT30.59602503
71PRKAA20.56896574
72CDK50.56529030
73ERBB20.56445368
74NTRK20.55508069
75NEK10.54049382
76PRKD10.51366089
77SIK20.50753448
78FGFR10.50436571
79SCYL20.49143562
80MAP2K30.48769214
81CDK60.48615746
82MET0.47360521
83PDPK10.46769685
84PRKCQ0.46491140
85CAMK2G0.46062499
86CSNK1E0.45144636
87STK380.45100991
88MAPK40.44461690
89JAK10.44074461
90PDK10.43960071
91SRC0.43476524
92RIPK10.43026023
93MAP3K120.42409928
94TESK10.41725438
95EGFR0.41666519
96ABL20.41521795
97PIK3CA0.41309365
98CAMK1D0.40499912
99ALK0.40399281
100CSK0.40005532

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.00638913
2Tryptophan metabolism_Homo sapiens_hsa003803.53837461
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30043307
4Glutathione metabolism_Homo sapiens_hsa004803.28736053
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.14867389
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.68180947
7Arginine biosynthesis_Homo sapiens_hsa002202.48963014
8Fatty acid degradation_Homo sapiens_hsa000712.45389677
9Arachidonic acid metabolism_Homo sapiens_hsa005902.44487683
10Thyroid hormone synthesis_Homo sapiens_hsa049182.28229291
11African trypanosomiasis_Homo sapiens_hsa051432.27190926
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24764289
13Fatty acid metabolism_Homo sapiens_hsa012122.13718419
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05541116
15Sulfur metabolism_Homo sapiens_hsa009201.98022545
16PPAR signaling pathway_Homo sapiens_hsa033201.91700359
17Complement and coagulation cascades_Homo sapiens_hsa046101.81813164
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81737696
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78997871
20Propanoate metabolism_Homo sapiens_hsa006401.72427015
21Butanoate metabolism_Homo sapiens_hsa006501.61360808
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53909042
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53635113
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51640984
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31901587
26beta-Alanine metabolism_Homo sapiens_hsa004101.31370282
27Starch and sucrose metabolism_Homo sapiens_hsa005001.28591180
28Pyruvate metabolism_Homo sapiens_hsa006201.24609677
29Bile secretion_Homo sapiens_hsa049761.24187719
30Glycerolipid metabolism_Homo sapiens_hsa005611.21832277
31Phenylalanine metabolism_Homo sapiens_hsa003601.16882537
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16570455
33Peroxisome_Homo sapiens_hsa041461.15571824
34Histidine metabolism_Homo sapiens_hsa003401.14028723
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13960965
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09937163
37Fatty acid elongation_Homo sapiens_hsa000621.04354470
38Fat digestion and absorption_Homo sapiens_hsa049751.01472971
39Staphylococcus aureus infection_Homo sapiens_hsa051501.00462662
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98762050
41Carbon metabolism_Homo sapiens_hsa012000.97086778
42Chemical carcinogenesis_Homo sapiens_hsa052040.97043055
43Vitamin B6 metabolism_Homo sapiens_hsa007500.94161327
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92080315
45Biosynthesis of amino acids_Homo sapiens_hsa012300.90801821
46Arginine and proline metabolism_Homo sapiens_hsa003300.90527149
47Folate biosynthesis_Homo sapiens_hsa007900.86832433
48Tyrosine metabolism_Homo sapiens_hsa003500.84415934
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82238923
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80911872
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.77723890
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74661296
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.71879340
54Salivary secretion_Homo sapiens_hsa049700.70307911
55Prion diseases_Homo sapiens_hsa050200.69642216
56ABC transporters_Homo sapiens_hsa020100.69598977
57Fatty acid biosynthesis_Homo sapiens_hsa000610.69397963
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67287089
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65707106
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.65367656
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61565286
62Caffeine metabolism_Homo sapiens_hsa002320.59283958
63Renin secretion_Homo sapiens_hsa049240.59158707
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57851716
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54688623
66Gastric acid secretion_Homo sapiens_hsa049710.54609995
67Lysosome_Homo sapiens_hsa041420.54376124
68Retinol metabolism_Homo sapiens_hsa008300.51469567
69Selenocompound metabolism_Homo sapiens_hsa004500.49970503
70GABAergic synapse_Homo sapiens_hsa047270.48671837
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.48105258
72Glucagon signaling pathway_Homo sapiens_hsa049220.46089405
73Steroid biosynthesis_Homo sapiens_hsa001000.44739845
74Insulin resistance_Homo sapiens_hsa049310.40332104
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37250747
76Estrogen signaling pathway_Homo sapiens_hsa049150.31073261
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30073654
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.29515009
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27293506
80Long-term potentiation_Homo sapiens_hsa047200.27212938
81AMPK signaling pathway_Homo sapiens_hsa041520.25918576
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.23640088
83Circadian entrainment_Homo sapiens_hsa047130.23499751
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22963139
85Pentose phosphate pathway_Homo sapiens_hsa000300.22644093
86Collecting duct acid secretion_Homo sapiens_hsa049660.22615003
87Metabolic pathways_Homo sapiens_hsa011000.21035921
88Lysine degradation_Homo sapiens_hsa003100.19985263
89Insulin signaling pathway_Homo sapiens_hsa049100.19539200
90Vibrio cholerae infection_Homo sapiens_hsa051100.17262450
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.14842985
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13068518
93Insulin secretion_Homo sapiens_hsa049110.13034571
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.11412020
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.11032045
96Glutamatergic synapse_Homo sapiens_hsa047240.10727425
97Oxytocin signaling pathway_Homo sapiens_hsa049210.09408111
98Amphetamine addiction_Homo sapiens_hsa050310.09091147
99Dilated cardiomyopathy_Homo sapiens_hsa054140.08379316
100GnRH signaling pathway_Homo sapiens_hsa049120.08178737

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