RNASE12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)9.28111019
2regulation of clathrin-mediated endocytosis (GO:2000369)7.01188172
3positive regulation of antigen processing and presentation (GO:0002579)6.01985271
4production of molecular mediator involved in inflammatory response (GO:0002532)5.81419484
5regulation of T cell tolerance induction (GO:0002664)5.65232081
6positive regulation of tolerance induction (GO:0002645)5.50478922
7fusion of sperm to egg plasma membrane (GO:0007342)5.24585201
8regulation of acrosome reaction (GO:0060046)5.22125767
9negative regulation of receptor-mediated endocytosis (GO:0048261)4.85230700
10L-serine transport (GO:0015825)4.73316993
11regulation of tolerance induction (GO:0002643)4.69739645
12regulation of antigen processing and presentation (GO:0002577)4.61563705
13ribosomal small subunit assembly (GO:0000028)4.39555129
14complement activation, alternative pathway (GO:0006957)4.34223847
15kynurenine metabolic process (GO:0070189)4.31714580
16serine transport (GO:0032329)4.18750918
17viral transcription (GO:0019083)4.16689934
18regulation of chronic inflammatory response (GO:0002676)4.12757611
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.05893222
20translational termination (GO:0006415)3.97264475
21negative regulation of phagocytosis (GO:0050765)3.97060584
22sulfur amino acid catabolic process (GO:0000098)3.93064614
23valine metabolic process (GO:0006573)3.90184991
24respiratory burst (GO:0045730)3.89451711
25plasma membrane fusion (GO:0045026)3.86992158
26regulation of Cdc42 GTPase activity (GO:0043088)3.85260366
27positive regulation of mast cell degranulation (GO:0043306)3.78141526
28positive regulation of mast cell activation involved in immune response (GO:0033008)3.78141526
29positive regulation of histone deacetylation (GO:0031065)3.74994136
30sperm capacitation (GO:0048240)3.60645533
31negative regulation of endopeptidase activity (GO:0010951)3.59265968
32pentose-phosphate shunt (GO:0006098)3.55418193
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51979740
34cotranslational protein targeting to membrane (GO:0006613)3.49372092
35protein targeting to ER (GO:0045047)3.46281135
36Golgi transport vesicle coating (GO:0048200)3.44671331
37COPI coating of Golgi vesicle (GO:0048205)3.44671331
38translational elongation (GO:0006414)3.44578787
39alpha-linolenic acid metabolic process (GO:0036109)3.44117830
40negative regulation of peptidase activity (GO:0010466)3.40370466
41B cell receptor signaling pathway (GO:0050853)3.35969363
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31620799
43response to misfolded protein (GO:0051788)3.24665838
44positive regulation of leukocyte degranulation (GO:0043302)3.22454620
45protein localization to endoplasmic reticulum (GO:0070972)3.21047233
46NADPH regeneration (GO:0006740)3.19496713
47positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.18079642
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10436746
49triglyceride catabolic process (GO:0019433)3.10164601
50regulation of hydrogen peroxide metabolic process (GO:0010310)3.06820315
51positive regulation of B cell differentiation (GO:0045579)3.04754982
52viral life cycle (GO:0019058)3.04123347
53regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.03044605
54protein complex disassembly (GO:0043241)3.01210840
55positive regulation of mast cell activation (GO:0033005)3.01033738
56ethanol oxidation (GO:0006069)3.00673682
57negative regulation of endocytosis (GO:0045806)2.98976949
58cellular protein complex disassembly (GO:0043624)2.97629983
59oxaloacetate metabolic process (GO:0006107)2.95377080
60low-density lipoprotein particle clearance (GO:0034383)2.94715124
61negative regulation of protein autophosphorylation (GO:0031953)2.89992879
62response to nitrosative stress (GO:0051409)2.88744056
63positive regulation of protein deacetylation (GO:0090312)2.85041940
64adaptation of signaling pathway (GO:0023058)2.84964558
65negative regulation of metanephros development (GO:0072217)2.84784185
66single fertilization (GO:0007338)2.82783857
67negative regulation of interleukin-10 production (GO:0032693)2.81217217
68folic acid-containing compound biosynthetic process (GO:0009396)2.79842650
69cellular sodium ion homeostasis (GO:0006883)2.79257022
70ribosomal small subunit biogenesis (GO:0042274)2.79125864
71acylglycerol catabolic process (GO:0046464)2.76972956
72neutral lipid catabolic process (GO:0046461)2.76972956
73white fat cell differentiation (GO:0050872)2.75971324
74brown fat cell differentiation (GO:0050873)2.75705748
75L-serine metabolic process (GO:0006563)2.69680969
76macromolecular complex disassembly (GO:0032984)2.66881239
77cellular extravasation (GO:0045123)2.65766705
78heterotypic cell-cell adhesion (GO:0034113)2.65469155
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65255515
80indole-containing compound catabolic process (GO:0042436)2.63064031
81indolalkylamine catabolic process (GO:0046218)2.63064031
82tryptophan catabolic process (GO:0006569)2.63064031
83positive regulation of receptor biosynthetic process (GO:0010870)2.61996690
84translational initiation (GO:0006413)2.60742455
85macroautophagy (GO:0016236)2.60431317
86natural killer cell differentiation (GO:0001779)2.58755565
87negative regulation of granulocyte differentiation (GO:0030853)2.55100403
88positive regulation of gamma-delta T cell activation (GO:0046645)2.52433572
89GPI anchor biosynthetic process (GO:0006506)2.52418068
90positive regulation of lamellipodium assembly (GO:0010592)2.50709811
91benzene-containing compound metabolic process (GO:0042537)2.49522378
92hypotonic response (GO:0006971)2.47611171
93mannose metabolic process (GO:0006013)2.45852156
94negative regulation of proteolysis (GO:0045861)2.45464075
95phospholipid homeostasis (GO:0055091)2.45272884
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)16.9130351
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)16.9130351
98antigen processing and presentation via MHC class Ib (GO:0002475)14.4975009
99antigen processing and presentation of endogenous antigen (GO:0019883)14.0779607
100regulation of antigen processing and presentation of peptide antigen (GO:0002583)12.4717317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human9.78317540
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.51177354
3E2F7_22180533_ChIP-Seq_HELA_Human4.20996496
4MYC_22102868_ChIP-Seq_BL_Human3.28267517
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.16991971
6ZNF263_19887448_ChIP-Seq_K562_Human2.85389645
7VDR_21846776_ChIP-Seq_THP-1_Human2.63869017
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.60499130
9CLOCK_20551151_ChIP-Seq_293T_Human2.40995355
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33775224
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19875533
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14233505
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.11288102
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11243348
15SCL_19346495_ChIP-Seq_HPC-7_Human2.08866733
16* VDR_24763502_ChIP-Seq_THP-1_Human2.07278060
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02806326
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88107018
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85396306
20ELF1_20517297_ChIP-Seq_JURKAT_Human1.83792168
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82904573
22UTX_26944678_Chip-Seq_JUKART_Human1.76739855
23AR_21572438_ChIP-Seq_LNCaP_Human1.75039882
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74637994
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74159635
26TCF7_22412390_ChIP-Seq_EML_Mouse1.70554274
27* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70468611
28LXR_22292898_ChIP-Seq_THP-1_Human1.69039192
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67230936
30* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63786890
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62106040
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61936499
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60245344
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50275862
35MYB_26560356_Chip-Seq_TH2_Human1.48645699
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.46628691
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.44846266
38KDM2B_26808549_Chip-Seq_DND41_Human1.43480493
39MAF_26560356_Chip-Seq_TH1_Human1.40700711
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.39748597
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38943203
42CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38778308
43MYB_26560356_Chip-Seq_TH1_Human1.37228243
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36956037
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.34444083
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34384469
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34304745
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33074621
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32179460
50RUNX_20019798_ChIP-Seq_JUKART_Human1.31822056
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29223353
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28740861
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.27172930
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25423516
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22951391
56P68_20966046_ChIP-Seq_HELA_Human1.22146633
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21793685
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19582003
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18510387
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.16565843
61TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15424933
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15411224
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13603505
64MYC_19915707_ChIP-ChIP_AK7_Human1.11436133
65NCOR1_26117541_ChIP-Seq_K562_Human1.08774958
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.07557433
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06801571
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06752761
69* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05239764
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04871660
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04815602
72FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04549764
73P300_27268052_Chip-Seq_Bcells_Human1.04468331
74GATA3_27048872_Chip-Seq_THYMUS_Human1.03589362
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00251789
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00215371
77SPI1_23547873_ChIP-Seq_NB4_Human0.99986846
78* BCOR_27268052_Chip-Seq_Bcells_Human0.99805148
79BCL6_27268052_Chip-Seq_Bcells_Human0.99612790
80ESR2_21235772_ChIP-Seq_MCF-7_Human0.98439485
81GATA1_19941826_ChIP-Seq_K562_Human0.96835909
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95207271
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95027382
84GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94250108
85SPI1_23127762_ChIP-Seq_K562_Human0.94008190
86XRN2_22483619_ChIP-Seq_HELA_Human0.93625163
87FLI1_21867929_ChIP-Seq_CD8_Mouse0.93493767
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90626975
89MAF_26560356_Chip-Seq_TH2_Human0.90186227
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86052263
91TET1_21451524_ChIP-Seq_MESCs_Mouse0.85961644
92TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85539199
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85237133
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84971412
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83432428
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83061883
97STAT1_17558387_ChIP-Seq_HELA_Human0.81757661
98GATA3_26560356_Chip-Seq_TH2_Human0.81304454
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81112478
100CEBPB_22108803_ChIP-Seq_LS180_Human0.80900753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.08599917
2MP0003300_gastrointestinal_ulcer3.53385204
3MP0003303_peritoneal_inflammation3.47974242
4MP0000685_abnormal_immune_system3.02054357
5MP0002139_abnormal_hepatobiliary_system2.97344556
6MP0002396_abnormal_hematopoietic_system2.72687993
7MP0005670_abnormal_white_adipose2.48976445
8MP0010234_abnormal_vibrissa_follicle2.42016195
9MP0005666_abnormal_adipose_tissue2.19617303
10MP0004130_abnormal_muscle_cell2.17918019
11MP0003191_abnormal_cellular_cholesterol2.09731580
12MP0005375_adipose_tissue_phenotype2.04873271
13MP0002166_altered_tumor_susceptibility2.02621703
14MP0004185_abnormal_adipocyte_glucose2.00483085
15MP0010352_gastrointestinal_tract_polyps1.99636718
16MP0003436_decreased_susceptibility_to1.99489987
17MP0001800_abnormal_humoral_immune1.98613792
18MP0005464_abnormal_platelet_physiology1.94181177
19MP0001545_abnormal_hematopoietic_system1.87446496
20MP0005397_hematopoietic_system_phenotyp1.87446496
21MP0001853_heart_inflammation1.83302817
22MP0000003_abnormal_adipose_tissue1.71018973
23MP0010329_abnormal_lipoprotein_level1.68690996
24MP0002452_abnormal_antigen_presenting1.66360002
25MP0005360_urolithiasis1.66045106
26MP0001661_extended_life_span1.64552978
27MP0002398_abnormal_bone_marrow1.60452220
28MP0000689_abnormal_spleen_morphology1.57106640
29MP0005584_abnormal_enzyme/coenzyme_acti1.56813756
30MP0001835_abnormal_antigen_presentation1.56625220
31MP0004808_abnormal_hematopoietic_stem1.56220001
32MP0001819_abnormal_immune_cell1.50041735
33MP0004947_skin_inflammation1.49615927
34MP0002420_abnormal_adaptive_immunity1.47033877
35MP0001790_abnormal_immune_system1.42511082
36MP0005387_immune_system_phenotype1.42511082
37MP0006054_spinal_hemorrhage1.40662722
38MP0000716_abnormal_immune_system1.39502748
39MP0002722_abnormal_immune_system1.36767378
40MP0003566_abnormal_cell_adhesion1.35021743
41MP0009643_abnormal_urine_homeostasis1.33002978
42MP0002723_abnormal_immune_serum1.32005259
43MP0008961_abnormal_basal_metabolism1.29113983
44MP0002006_tumorigenesis1.28840392
45MP0003195_calcinosis1.27644826
46MP0002970_abnormal_white_adipose1.24421609
47MP0009278_abnormal_bone_marrow1.23327637
48MP0003705_abnormal_hypodermis_morpholog1.21641749
49MP0001765_abnormal_ion_homeostasis1.21072861
50MP0002429_abnormal_blood_cell1.19310319
51MP0005334_abnormal_fat_pad1.18874073
52MP0003656_abnormal_erythrocyte_physiolo1.18398869
53MP0004043_abnormal_pH_regulation1.18219816
54MP0003075_altered_response_to1.17608736
55MP0009115_abnormal_fat_cell1.17103535
56MP0001501_abnormal_sleep_pattern1.14645016
57MP0005671_abnormal_response_to1.13606415
58MP0009763_increased_sensitivity_to1.11630111
59MP0000609_abnormal_liver_physiology1.11608011
60MP0002118_abnormal_lipid_homeostasis1.11036804
61MP0003866_abnormal_defecation1.10166294
62MP0009785_altered_susceptibility_to1.09166759
63MP0001533_abnormal_skeleton_physiology1.09151692
64MP0002136_abnormal_kidney_physiology1.07992912
65MP0001845_abnormal_inflammatory_respons1.07805393
66MP0002419_abnormal_innate_immunity1.06470739
67MP0002138_abnormal_hepatobiliary_system1.06052171
68MP0005025_abnormal_response_to1.05731339
69MP0005000_abnormal_immune_tolerance1.02479571
70MP0002971_abnormal_brown_adipose1.01337181
71MP0002148_abnormal_hypersensitivity_rea1.00129331
72MP0005365_abnormal_bile_salt0.99883767
73MP0001756_abnormal_urination0.96482773
74MP0000703_abnormal_thymus_morphology0.95294922
75MP0003724_increased_susceptibility_to0.95247543
76MP0010155_abnormal_intestine_physiology0.95033668
77MP0002909_abnormal_adrenal_gland0.94610681
78MP0009379_abnormal_foot_pigmentation0.94353745
79MP0005410_abnormal_fertilization0.93057701
80MP0003959_abnormal_lean_body0.92447240
81MP0003045_fibrosis0.90086260
82MP0005636_abnormal_mineral_homeostasis0.89640834
83MP0003646_muscle_fatigue0.88772030
84MP0002254_reproductive_system_inflammat0.83850137
85MP0008438_abnormal_cutaneous_collagen0.82654057
86MP0004036_abnormal_muscle_relaxation0.80797595
87MP0000598_abnormal_liver_morphology0.80404470
88MP0001764_abnormal_homeostasis0.80218312
89MP0005319_abnormal_enzyme/_coenzyme0.79525708
90MP0002796_impaired_skin_barrier0.76572908
91MP0000858_altered_metastatic_potential0.71991758
92MP0003183_abnormal_peptide_metabolism0.71760355
93MP0000604_amyloidosis0.70393092
94MP0003806_abnormal_nucleotide_metabolis0.70145219
95MP0000490_abnormal_crypts_of0.70124896
96MP0000249_abnormal_blood_vessel0.69797270
97MP0005166_decreased_susceptibility_to0.67650092
98MP0000477_abnormal_intestine_morphology0.67469200
99MP0003186_abnormal_redox_activity0.67438374
100MP0008469_abnormal_protein_level0.66459294

Predicted human phenotypes

RankGene SetZ-score
1Choroideremia (HP:0001139)5.95826845
2Abnormal rod and cone electroretinograms (HP:0008323)5.66932807
3Cellulitis (HP:0100658)5.55939888
4Abnormality of the fovea (HP:0000493)5.38366390
5Agammaglobulinemia (HP:0004432)5.37490668
6Complement deficiency (HP:0004431)5.00900551
711 pairs of ribs (HP:0000878)4.85744017
8Vacuolated lymphocytes (HP:0001922)4.84930426
9Metaphyseal cupping (HP:0003021)4.80771244
10Bony spicule pigmentary retinopathy (HP:0007737)4.69720667
11Chronic otitis media (HP:0000389)4.52106909
12Recurrent gram-negative bacterial infections (HP:0005420)4.35094310
13Hypopigmentation of the fundus (HP:0007894)3.91296749
14Verrucae (HP:0200043)3.74262408
15Papilloma (HP:0012740)3.74262408
16Facial diplegia (HP:0001349)3.73832759
17Abnormality of complement system (HP:0005339)3.49129909
18Potter facies (HP:0002009)3.26425560
19Facial shape deformation (HP:0011334)3.26425560
20Recurrent bronchitis (HP:0002837)3.16653550
21Osteomyelitis (HP:0002754)3.15508629
22Stridor (HP:0010307)3.12125266
23Missing ribs (HP:0000921)3.11598199
24Thrombocytosis (HP:0001894)3.10845673
25Abnormality of cells of the erythroid lineage (HP:0012130)3.06198129
26Hand muscle atrophy (HP:0009130)3.05778947
27Abnormality of the calcaneus (HP:0008364)3.05071392
28Myocardial infarction (HP:0001658)2.88445801
29Vascular calcification (HP:0004934)2.81154434
30Small epiphyses (HP:0010585)2.77151919
31Autoimmune thrombocytopenia (HP:0001973)2.74904142
32Reticulocytopenia (HP:0001896)2.66131208
33IgM deficiency (HP:0002850)2.61710143
34Intention tremor (HP:0002080)2.60373221
35Abnormal number of erythroid precursors (HP:0012131)2.59866442
36Cardiovascular calcification (HP:0011915)2.53697065
37Chronic sinusitis (HP:0011109)2.41768365
38Recurrent viral infections (HP:0004429)2.41134820
39Upper limb amyotrophy (HP:0009129)2.40493472
40Distal upper limb amyotrophy (HP:0007149)2.40493472
41Increased density of long bones (HP:0006392)2.38824369
42Dysostosis multiplex (HP:0000943)2.35791185
43Cerebral inclusion bodies (HP:0100314)2.29060297
44Abnormal hemoglobin (HP:0011902)2.25807169
45Meningitis (HP:0001287)2.25243000
46Neurofibrillary tangles (HP:0002185)2.24826857
47Cutaneous melanoma (HP:0012056)2.23069864
48Abnormality of the lumbar spine (HP:0100712)2.21883742
49Sepsis (HP:0100806)2.18861283
50Hyperphosphatemia (HP:0002905)2.17903800
51Vertebral arch anomaly (HP:0008438)2.16480343
52Mitral stenosis (HP:0001718)2.15512098
53Hypertriglyceridemia (HP:0002155)2.12627573
54Gastrointestinal inflammation (HP:0004386)2.09232748
55Papilledema (HP:0001085)2.08747645
56Vertebral hypoplasia (HP:0008417)2.07961525
57Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07961525
58Hyperglycinuria (HP:0003108)2.07669869
59Colitis (HP:0002583)2.01246640
60Supranuclear gaze palsy (HP:0000605)2.00676735
61Interstitial pulmonary disease (HP:0006530)2.00548943
62Ulnar bowing (HP:0003031)1.99941442
63Action tremor (HP:0002345)1.99903613
64Abnormality of macrophages (HP:0004311)1.99594081
65Abnormality of purine metabolism (HP:0004352)1.98481877
66Pallor (HP:0000980)1.96673625
67Prolonged bleeding time (HP:0003010)1.96220081
68Loss of speech (HP:0002371)1.95452888
69Diaphragmatic weakness (HP:0009113)1.94266774
70Neoplasm of the heart (HP:0100544)1.93361554
71Inflammation of the large intestine (HP:0002037)1.92808045
72Skin rash (HP:0000988)1.90234673
73Oligomenorrhea (HP:0000876)1.89567924
74Hematochezia (HP:0002573)1.89553319
75Pseudobulbar signs (HP:0002200)1.89380739
76Recurrent sinusitis (HP:0011108)1.88129552
77Abnormality of the nasal mucosa (HP:0000433)1.87368976
78Thyroiditis (HP:0100646)1.86575774
79Nasal polyposis (HP:0100582)1.84992463
80Slender build (HP:0001533)1.80655141
81Spastic diplegia (HP:0001264)1.80150894
82Short 4th metacarpal (HP:0010044)1.77695593
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77695593
84Bronchitis (HP:0012387)1.77477501
85Abnormal platelet volume (HP:0011876)1.75805332
86Macroorchidism (HP:0000053)1.73184862
87Macrocytic anemia (HP:0001972)1.72724667
88Multiple enchondromatosis (HP:0005701)1.72432974
89Thoracic kyphosis (HP:0002942)1.72143614
90Hypoplasia of the thymus (HP:0000778)1.70098687
91Infantile muscular hypotonia (HP:0008947)1.69798598
92Acrocyanosis (HP:0001063)1.67999681
93Fatigue (HP:0012378)1.67826071
94Aortic aneurysm (HP:0004942)1.67445046
95Hemiplegia (HP:0002301)1.67361248
96Abnormality of serine family amino acid metabolism (HP:0010894)1.67092769
97Abnormality of glycine metabolism (HP:0010895)1.67092769
98Urinary glycosaminoglycan excretion (HP:0003541)1.65582988
99Mucopolysacchariduria (HP:0008155)1.65582988
100Ankle clonus (HP:0011448)1.64634964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K6.36779546
2PKN24.42001651
3ERN13.84074581
4MAP3K103.69581389
5TAOK32.99809345
6LRRK22.76603549
7TRIB32.60100491
8SIK22.38812041
9SIK12.24560527
10FRK2.20709124
11LMTK22.11605136
12CLK12.05331328
13GRK62.03152376
14RPS6KB22.01174119
15STK101.92951041
16FLT31.88857886
17RIPK41.86312600
18MAP4K11.84727208
19MST41.70016377
20FGFR21.62428556
21MYLK1.61892483
22SCYL21.56662841
23BTK1.56033932
24NEK21.53354378
25SYK1.45530523
26FES1.45323884
27PAK21.43118212
28MAPKAPK31.40874140
29CDK191.23428843
30BLK1.19650877
31CSF1R1.17580417
32MAPK111.15456056
33MAPK121.14096221
34TNK21.07354133
35TGFBR11.04398082
36BMX0.96279895
37TTK0.91162473
38PASK0.89372054
39CDK60.88802745
40RET0.82703797
41CAMK1D0.81580816
42FGFR30.81037545
43MAP3K80.77163065
44RIPK10.76579622
45TEC0.75139551
46LYN0.74958457
47ITK0.74161669
48JAK20.73913682
49ILK0.73645124
50CAMK1G0.72634345
51CDK40.71072392
52HIPK20.70851208
53RPS6KB10.69312629
54MAP3K120.68286714
55MAP3K70.64279303
56MAPK40.64160869
57EPHB10.63288309
58ALK0.63173799
59WNK10.62419516
60PRKCH0.61445710
61PDK10.57659450
62STK30.56912628
63TTN0.54991949
64MAPKAPK20.54755556
65STK40.54554466
66FGFR40.54491917
67LCK0.53834087
68TGFBR20.50851816
69TYK20.48196282
70PTK60.47318164
71IRAK30.46996100
72MATK0.45176673
73CAMK10.43598189
74JAK30.43356248
75KIT0.42728824
76MAPK130.42454782
77PDK40.40907957
78PDK30.40907957
79EGFR0.40728835
80WNK40.40725266
81JAK10.40676910
82PDGFRA0.39737012
83FYN0.38923982
84HCK0.37420922
85SRC0.34890135
86BCKDK0.34888973
87PIK3CG0.31921776
88RPS6KA40.31481855
89MTOR0.30850523
90ATR0.30413602
91DAPK10.29925334
92PRKD10.28243246
93PAK40.27683000
94TBK10.27668411
95INSR0.24430306
96MAPK30.24294696
97DYRK1B0.23200412
98KSR20.19936608
99ZAP700.19542263
100EIF2AK30.17840701

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.68899310
2Nitrogen metabolism_Homo sapiens_hsa009103.47943612
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.39785034
4Other glycan degradation_Homo sapiens_hsa005112.39755721
5Primary immunodeficiency_Homo sapiens_hsa053402.37780283
6ABC transporters_Homo sapiens_hsa020102.33872814
7Ribosome_Homo sapiens_hsa030102.33670711
8PPAR signaling pathway_Homo sapiens_hsa033202.29861329
9B cell receptor signaling pathway_Homo sapiens_hsa046622.25986856
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.25860583
11Fatty acid metabolism_Homo sapiens_hsa012122.24334930
12Thyroid hormone synthesis_Homo sapiens_hsa049182.23135437
13Fatty acid degradation_Homo sapiens_hsa000712.16702010
14Glutathione metabolism_Homo sapiens_hsa004802.14401201
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.12994973
16Asthma_Homo sapiens_hsa053102.12938308
17Glycerolipid metabolism_Homo sapiens_hsa005612.07813435
18Sulfur metabolism_Homo sapiens_hsa009201.92052569
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62936681
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57026050
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51353253
22Salivary secretion_Homo sapiens_hsa049701.51171113
23Arachidonic acid metabolism_Homo sapiens_hsa005901.32646044
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31193012
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30111464
26Tryptophan metabolism_Homo sapiens_hsa003801.25306622
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21982477
28Renin-angiotensin system_Homo sapiens_hsa046141.14046451
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13405521
30Carbon metabolism_Homo sapiens_hsa012001.11513539
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11096623
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10576013
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09661188
34Propanoate metabolism_Homo sapiens_hsa006401.07705665
35African trypanosomiasis_Homo sapiens_hsa051431.07050315
36Glioma_Homo sapiens_hsa052141.03575811
37Pentose phosphate pathway_Homo sapiens_hsa000301.01553151
38Platelet activation_Homo sapiens_hsa046111.01274797
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.00565070
40Non-small cell lung cancer_Homo sapiens_hsa052230.99590812
41Biosynthesis of amino acids_Homo sapiens_hsa012300.97459961
42Adipocytokine signaling pathway_Homo sapiens_hsa049200.94746111
43Fatty acid biosynthesis_Homo sapiens_hsa000610.93503911
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.92751173
45N-Glycan biosynthesis_Homo sapiens_hsa005100.91577521
46Pyruvate metabolism_Homo sapiens_hsa006200.90743482
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90558669
48Arginine biosynthesis_Homo sapiens_hsa002200.90073054
49Insulin resistance_Homo sapiens_hsa049310.85527297
50Lysosome_Homo sapiens_hsa041420.83596154
51AMPK signaling pathway_Homo sapiens_hsa041520.82113159
52One carbon pool by folate_Homo sapiens_hsa006700.79041677
53Chronic myeloid leukemia_Homo sapiens_hsa052200.78349162
54Acute myeloid leukemia_Homo sapiens_hsa052210.75475750
55beta-Alanine metabolism_Homo sapiens_hsa004100.71552518
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71272831
57Gastric acid secretion_Homo sapiens_hsa049710.70824528
58Fat digestion and absorption_Homo sapiens_hsa049750.70553815
59Phenylalanine metabolism_Homo sapiens_hsa003600.70205077
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68100991
61mTOR signaling pathway_Homo sapiens_hsa041500.66421870
62HIF-1 signaling pathway_Homo sapiens_hsa040660.66016091
63Tyrosine metabolism_Homo sapiens_hsa003500.65650309
64Renin secretion_Homo sapiens_hsa049240.65069295
65Staphylococcus aureus infection_Homo sapiens_hsa051500.64978372
66Selenocompound metabolism_Homo sapiens_hsa004500.64378352
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.62250975
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61447300
69Type II diabetes mellitus_Homo sapiens_hsa049300.60958409
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60764857
71Inositol phosphate metabolism_Homo sapiens_hsa005620.57923034
72Leishmaniasis_Homo sapiens_hsa051400.57862151
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.57543638
74Complement and coagulation cascades_Homo sapiens_hsa046100.56310133
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54974556
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.54570195
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.53408248
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52825083
79VEGF signaling pathway_Homo sapiens_hsa043700.51811267
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51479915
81Prion diseases_Homo sapiens_hsa050200.50345651
82Antigen processing and presentation_Homo sapiens_hsa046120.49367306
83Vitamin B6 metabolism_Homo sapiens_hsa007500.49250532
84Estrogen signaling pathway_Homo sapiens_hsa049150.46360784
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45463718
86Pancreatic cancer_Homo sapiens_hsa052120.44450930
87Peroxisome_Homo sapiens_hsa041460.44122289
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43535547
89Osteoclast differentiation_Homo sapiens_hsa043800.41036008
90Pancreatic secretion_Homo sapiens_hsa049720.40631570
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39742283
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34001838
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33760739
94Insulin signaling pathway_Homo sapiens_hsa049100.33693440
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31535183
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31240248
97Toxoplasmosis_Homo sapiens_hsa051450.30400916
98Protein digestion and absorption_Homo sapiens_hsa049740.28690409
99Caffeine metabolism_Homo sapiens_hsa002320.27858955
100Base excision repair_Homo sapiens_hsa034100.27832569

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