RMND5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.41482345
2nuclear pore organization (GO:0006999)5.71691129
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.29547333
4L-phenylalanine catabolic process (GO:0006559)5.29547333
5L-phenylalanine metabolic process (GO:0006558)4.95700589
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.95700589
7mitotic sister chromatid cohesion (GO:0007064)4.83229087
8alpha-linolenic acid metabolic process (GO:0036109)4.67371850
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.56464732
10aromatic amino acid family catabolic process (GO:0009074)4.55744408
11pore complex assembly (GO:0046931)4.49430361
12kynurenine metabolic process (GO:0070189)4.27112281
13urea metabolic process (GO:0019627)4.26284449
14urea cycle (GO:0000050)4.26284449
15dicarboxylic acid biosynthetic process (GO:0043650)4.13371847
16lysine metabolic process (GO:0006553)4.12547717
17lysine catabolic process (GO:0006554)4.12547717
18regulation of relaxation of muscle (GO:1901077)4.10934117
19bile acid biosynthetic process (GO:0006699)4.10050404
20cysteine metabolic process (GO:0006534)4.06785186
21indole-containing compound catabolic process (GO:0042436)3.91044375
22indolalkylamine catabolic process (GO:0046218)3.91044375
23tryptophan catabolic process (GO:0006569)3.91044375
24cardiac muscle hypertrophy (GO:0003300)3.89697003
25serine family amino acid catabolic process (GO:0009071)3.89657530
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.86664825
27sulfur amino acid catabolic process (GO:0000098)3.84344835
28complement activation, alternative pathway (GO:0006957)3.80452478
29glutamate metabolic process (GO:0006536)3.80441588
30nitrogen cycle metabolic process (GO:0071941)3.78882983
31negative regulation of thymocyte apoptotic process (GO:0070244)3.78299465
32regulation of cholesterol homeostasis (GO:2000188)3.76752381
33negative regulation of fibrinolysis (GO:0051918)3.72702440
34high-density lipoprotein particle remodeling (GO:0034375)3.71591393
35tryptophan metabolic process (GO:0006568)3.71428456
36glyoxylate metabolic process (GO:0046487)3.70091259
37regulation of protein activation cascade (GO:2000257)3.67495600
382-oxoglutarate metabolic process (GO:0006103)3.67041911
39protein carboxylation (GO:0018214)3.65104143
40peptidyl-glutamic acid carboxylation (GO:0017187)3.65104143
41bile acid metabolic process (GO:0008206)3.64698105
42striated muscle hypertrophy (GO:0014897)3.63878247
43cellular ketone body metabolic process (GO:0046950)3.61292751
44V(D)J recombination (GO:0033151)3.60266598
45DNA unwinding involved in DNA replication (GO:0006268)3.56155343
46pre-miRNA processing (GO:0031054)3.55750221
47homocysteine metabolic process (GO:0050667)3.53698859
48regulation of triglyceride catabolic process (GO:0010896)3.49803829
49valine metabolic process (GO:0006573)3.49328063
50amino-acid betaine metabolic process (GO:0006577)3.47781256
51regulation of histone H3-K9 methylation (GO:0051570)3.47630441
52regulation of fibrinolysis (GO:0051917)3.45460373
53definitive hemopoiesis (GO:0060216)3.45027102
54regulation of gamma-delta T cell differentiation (GO:0045586)3.44723541
55positive regulation of fatty acid beta-oxidation (GO:0032000)3.44014827
56negative regulation of sterol transport (GO:0032372)3.42885402
57negative regulation of cholesterol transport (GO:0032375)3.42885402
58regulation of complement activation (GO:0030449)3.42703478
59triglyceride homeostasis (GO:0070328)3.40918628
60acylglycerol homeostasis (GO:0055090)3.40918628
61phospholipid efflux (GO:0033700)3.39512779
62alpha-amino acid catabolic process (GO:1901606)3.36092196
63reverse cholesterol transport (GO:0043691)3.32781795
64DNA double-strand break processing (GO:0000729)3.32120509
65short-chain fatty acid metabolic process (GO:0046459)3.28174397
66negative regulation of peptidyl-lysine acetylation (GO:2000757)3.24131584
67tyrosine metabolic process (GO:0006570)3.23117754
68ethanol oxidation (GO:0006069)3.23011035
69drug catabolic process (GO:0042737)3.22696931
70regulation of fatty acid beta-oxidation (GO:0031998)3.22535537
71phospholipid homeostasis (GO:0055091)3.20721221
72negative regulation of histone acetylation (GO:0035067)3.18922410
73positive regulation of lipid catabolic process (GO:0050996)3.15591353
74cellular modified amino acid catabolic process (GO:0042219)3.15246785
75non-recombinational repair (GO:0000726)3.15067846
76double-strand break repair via nonhomologous end joining (GO:0006303)3.15067846
77cellular amino acid catabolic process (GO:0009063)3.14769571
78aromatic amino acid family metabolic process (GO:0009072)3.13758388
79protein-lipid complex remodeling (GO:0034368)3.13532037
80macromolecular complex remodeling (GO:0034367)3.13532037
81plasma lipoprotein particle remodeling (GO:0034369)3.13532037
82ketone body metabolic process (GO:1902224)3.11806507
83fatty acid transmembrane transport (GO:1902001)3.10708927
84acetyl-CoA metabolic process (GO:0006084)3.10153493
85ribosome assembly (GO:0042255)3.07332437
86regulation of bile acid biosynthetic process (GO:0070857)3.07312151
87cardiac muscle adaptation (GO:0014887)3.06249795
88cardiac muscle hypertrophy in response to stress (GO:0014898)3.06249795
89muscle hypertrophy in response to stress (GO:0003299)3.06249795
90muscle hypertrophy (GO:0014896)3.03989650
91bile acid and bile salt transport (GO:0015721)3.03350673
92cholesterol efflux (GO:0033344)3.02757900
93fatty acid homeostasis (GO:0055089)3.02654551
94aspartate family amino acid catabolic process (GO:0009068)3.02435767
95phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.01538062
96sarcoplasmic reticulum calcium ion transport (GO:0070296)3.00840960
97regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.99329829
98plasma lipoprotein particle clearance (GO:0034381)2.98625923
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98502443
100monoubiquitinated protein deubiquitination (GO:0035520)2.97609950
101plasma lipoprotein particle assembly (GO:0034377)2.97543471
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95495338
103mitotic chromosome condensation (GO:0007076)2.95126869
104muscle filament sliding (GO:0030049)2.94411218
105actin-myosin filament sliding (GO:0033275)2.94411218
106regulation of DNA endoreduplication (GO:0032875)2.93041974
107negative regulation of protein acetylation (GO:1901984)2.90738487
108histone mRNA catabolic process (GO:0071044)2.88775640
109myofibril assembly (GO:0030239)2.88772619
110positive regulation of mitotic sister chromatid separation (GO:1901970)2.88001687
111positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88001687
112positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88001687
113negative regulation of fatty acid biosynthetic process (GO:0045717)2.86986685
114carnitine shuttle (GO:0006853)2.85478154
115positive regulation of chromosome segregation (GO:0051984)2.84883583
116glycine metabolic process (GO:0006544)2.84651628
117protein-lipid complex assembly (GO:0065005)2.84149351
118NADH metabolic process (GO:0006734)2.83951142
119regulation of centriole replication (GO:0046599)2.83893962
120sister chromatid segregation (GO:0000819)2.83500977
121regulation of gamma-delta T cell activation (GO:0046643)2.83475742
122regulation of Rac protein signal transduction (GO:0035020)2.82384303
123genitalia morphogenesis (GO:0035112)2.81463305
124negative regulation of lipase activity (GO:0060192)2.81101247
125exogenous drug catabolic process (GO:0042738)2.79782507
126protein K11-linked deubiquitination (GO:0035871)2.79462270
127striated muscle contraction (GO:0006941)2.79222875
128regulation of cholesterol esterification (GO:0010872)2.78055628
129positive regulation of fatty acid oxidation (GO:0046321)2.77301831
130negative regulation of DNA recombination (GO:0045910)2.76908057
131positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.76347992
132cellular glucuronidation (GO:0052695)2.75896829
133cardiac muscle contraction (GO:0060048)2.75889553
134serine family amino acid metabolic process (GO:0009069)2.74513986
135regulation of actin filament-based movement (GO:1903115)2.74474795
136regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74464316
137coenzyme catabolic process (GO:0009109)2.73974871
138fatty acid oxidation (GO:0019395)2.71319586
139linoleic acid metabolic process (GO:0043651)2.71144505
140regulation of acyl-CoA biosynthetic process (GO:0050812)2.69058345
141acylglycerol catabolic process (GO:0046464)2.69014563
142neutral lipid catabolic process (GO:0046461)2.69014563
143fatty acid beta-oxidation (GO:0006635)2.68345351
144relaxation of cardiac muscle (GO:0055119)2.68332368
145histone H3-K9 demethylation (GO:0033169)2.67857884
146histone-serine phosphorylation (GO:0035404)2.67588050
147megakaryocyte development (GO:0035855)2.67351836
148indolalkylamine metabolic process (GO:0006586)2.65072748
149lipid oxidation (GO:0034440)2.64977956
150organic acid catabolic process (GO:0016054)2.64922537
151carboxylic acid catabolic process (GO:0046395)2.64922537
152mitotic G2 DNA damage checkpoint (GO:0007095)2.63935669
153cytolysis (GO:0019835)2.63680724
154mitotic nuclear envelope disassembly (GO:0007077)2.62695079
155tricarboxylic acid cycle (GO:0006099)2.62692943
156cholesterol homeostasis (GO:0042632)2.62684659
157regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.62344483
158positive regulation of insulin receptor signaling pathway (GO:0046628)2.62138743
159mitochondrial DNA replication (GO:0006264)2.60529335
160response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.59270902
161peptidyl-threonine phosphorylation (GO:0018107)2.58713186
162regulation of protein glycosylation (GO:0060049)2.57784310
163sister chromatid cohesion (GO:0007062)2.57549967
164mitotic metaphase plate congression (GO:0007080)2.57002764
165nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.56812158
166positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.56606200
167membrane disassembly (GO:0030397)2.55772368
168nuclear envelope disassembly (GO:0051081)2.55772368
169negative regulation of histone methylation (GO:0031061)2.55718199
170cell communication by electrical coupling (GO:0010644)2.55577903
171negative regulation of DNA-dependent DNA replication (GO:2000104)2.55041902
172DNA topological change (GO:0006265)2.53030652
173cell communication involved in cardiac conduction (GO:0086065)2.49991546
174mitotic G2/M transition checkpoint (GO:0044818)2.49208346
175cardiac myofibril assembly (GO:0055003)2.46229234
176IMP metabolic process (GO:0046040)2.45461992
177regulation of sister chromatid segregation (GO:0033045)2.44918791
178regulation of mitotic sister chromatid separation (GO:0010965)2.44918791
179regulation of mitotic sister chromatid segregation (GO:0033047)2.44918791
180metaphase plate congression (GO:0051310)2.44561917
181regulation of chromosome segregation (GO:0051983)2.44252507
182DNA duplex unwinding (GO:0032508)2.43346776
183negative regulation of histone modification (GO:0031057)2.43079449
184skeletal muscle contraction (GO:0003009)2.42380550
185striated muscle adaptation (GO:0014888)2.42060284
186actin-mediated cell contraction (GO:0070252)2.41509966
187regulation of cell communication by electrical coupling (GO:0010649)2.41291208
188cytoplasmic mRNA processing body assembly (GO:0033962)2.41086430
189glucan catabolic process (GO:0009251)2.40568652
190glycogen catabolic process (GO:0005980)2.40543394
191regulation of meiosis I (GO:0060631)2.39658616
192spindle checkpoint (GO:0031577)2.38205420
193DNA geometric change (GO:0032392)2.37222357
194relaxation of muscle (GO:0090075)2.36958447
195positive regulation of macroautophagy (GO:0016239)2.36215463
196regulation of cofactor metabolic process (GO:0051193)2.35994336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.15013980
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.85367330
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.04695304
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.41984410
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.38532184
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66964979
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.17761908
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.09717934
9* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98756754
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.98311497
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90627789
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.85136967
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67604783
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65017153
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28612535
16ZNF263_19887448_ChIP-Seq_K562_Human2.10704754
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09463042
18AR_21909140_ChIP-Seq_LNCAP_Human2.00485326
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99329794
20CLOCK_20551151_ChIP-Seq_293T_Human1.95474860
21TAF15_26573619_Chip-Seq_HEK293_Human1.93417881
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.91630937
23* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85466005
24GATA1_22025678_ChIP-Seq_K562_Human1.79967477
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.77580624
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.75822321
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74173353
28* FUS_26573619_Chip-Seq_HEK293_Human1.66773410
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66093538
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65937522
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.63875026
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63443259
33* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62524214
34IGF1R_20145208_ChIP-Seq_DFB_Human1.61360806
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.59531344
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55752257
37* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55259830
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52756533
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52339290
40EWS_26573619_Chip-Seq_HEK293_Human1.51965955
41* FOXO3_23340844_ChIP-Seq_DLD1_Human1.51772177
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51245026
43ELK1_19687146_ChIP-ChIP_HELA_Human1.50380873
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49156664
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.48727967
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.48578722
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45664779
48KDM2B_26808549_Chip-Seq_DND41_Human1.45101053
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44384813
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44360279
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44028096
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41338571
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.40757650
54SALL4_22934838_ChIP-ChIP_CD34+_Human1.40517931
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.40163640
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39074035
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38073833
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34859129
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.31787510
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30956075
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30483511
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30397770
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28836478
64KDM2B_26808549_Chip-Seq_K562_Human1.28741917
65GBX2_23144817_ChIP-Seq_PC3_Human1.28633845
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25514919
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25154972
68* TCF7_22412390_ChIP-Seq_EML_Mouse1.24649361
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23605038
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22626401
71P300_19829295_ChIP-Seq_ESCs_Human1.22501890
72GATA1_19941826_ChIP-Seq_K562_Human1.21144823
73SMAD4_21799915_ChIP-Seq_A2780_Human1.20866161
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20607371
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19314449
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16901594
77* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16817063
78RUNX_20019798_ChIP-Seq_JUKART_Human1.16175438
79ER_23166858_ChIP-Seq_MCF-7_Human1.15266201
80* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15074689
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.14387108
82SCL_19346495_ChIP-Seq_HPC-7_Human1.14379955
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.14082084
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.13673669
85TCF4_23295773_ChIP-Seq_U87_Human1.11902375
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11657878
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11229039
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.11061450
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10770723
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09905361
91HNF4A_19822575_ChIP-Seq_HepG2_Human1.09851096
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.09615485
93STAT3_23295773_ChIP-Seq_U87_Human1.09146951
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07793543
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07303928
96EGR1_19374776_ChIP-ChIP_THP-1_Human1.07195074
97* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07085488
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.07025443
99DROSHA_22980978_ChIP-Seq_HELA_Human1.06984011
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05729145
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.05620758
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05478786
103CREB1_26743006_Chip-Seq_LNCaP_Human1.05390111
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05134389
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04984432
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.04710875
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04160768
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04058075
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.03385378
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03336515
111* RUNX1_27514584_Chip-Seq_MCF-7_Human1.02986277
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02942270
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02866845
114MYC_22102868_ChIP-Seq_BL_Human1.02833541
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02809056
116KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02725168
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00552516
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99996825
119P53_22387025_ChIP-Seq_ESCs_Mouse0.99755762
120HTT_18923047_ChIP-ChIP_STHdh_Human0.99224426
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.97583653
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.97583653
123RXR_22108803_ChIP-Seq_LS180_Human0.97312744
124GATA2_19941826_ChIP-Seq_K562_Human0.96772061
125OCT4_18555785_Chip-Seq_ESCs_Mouse0.96160300
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95795085
127EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95139222
128P300_18555785_Chip-Seq_ESCs_Mouse0.94045778
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93219147
130CHD1_26751641_Chip-Seq_LNCaP_Human0.93159199
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93069064
132ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92909608
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92520115
134ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91095542
135KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90803184
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90539554
137SOX2_18555785_Chip-Seq_ESCs_Mouse0.90174617
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.89809191
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89261396
140AR_21572438_ChIP-Seq_LNCaP_Human0.89246717
141CDX2_22108803_ChIP-Seq_LS180_Human0.89019206
142FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88622355
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87975169
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87898571
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.87495239
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87449149
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86703916
148EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86315585
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86179180
150WT1_19549856_ChIP-ChIP_CCG9911_Human0.85911023
151CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85881528
152* FOXP3_21729870_ChIP-Seq_TREG_Human0.85692892
153KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85070461
154CTCF_18555785_Chip-Seq_ESCs_Mouse0.84918873
155FOXA1_25552417_ChIP-Seq_VCAP_Human0.84666809
156ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84464283
157CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84135119
158PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82943740
159FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.81767396
160FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81413362
161GATA6_25053715_ChIP-Seq_YYC3_Human0.81083320
162FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80976151
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.79869007
164AR_19668381_ChIP-Seq_PC3_Human0.79682732
165BCAT_22108803_ChIP-Seq_LS180_Human0.78858955
166MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78816534
167SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78686506
168FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78610923
169SMAD4_21741376_ChIP-Seq_HESCs_Human0.78602465
170RACK7_27058665_Chip-Seq_MCF-7_Human0.78580323
171SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78507379
172* GATA3_27048872_Chip-Seq_THYMUS_Human0.78493125
173SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78168075
174PIAS1_25552417_ChIP-Seq_VCAP_Human0.74825398
175TP53_16413492_ChIP-PET_HCT116_Human0.74759204
176AHR_22903824_ChIP-Seq_MCF-7_Human0.74295527
177SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.74188933
178ZFP281_18757296_ChIP-ChIP_E14_Mouse0.73730122
179ARNT_22903824_ChIP-Seq_MCF-7_Human0.73705243
180ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73503901
181FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73455209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.63340799
2MP0005360_urolithiasis5.87140789
3MP0005365_abnormal_bile_salt5.77848779
4MP0008057_abnormal_DNA_replication5.49355253
5MP0005085_abnormal_gallbladder_physiolo4.87506195
6MP0008875_abnormal_xenobiotic_pharmacok3.65062483
7MP0003252_abnormal_bile_duct3.43177464
8MP0010234_abnormal_vibrissa_follicle3.29998599
9MP0010329_abnormal_lipoprotein_level3.13092043
10MP0004084_abnormal_cardiac_muscle2.83506326
11MP0010094_abnormal_chromosome_stability2.80911055
12MP0004147_increased_porphyrin_level2.78895961
13MP0004130_abnormal_muscle_cell2.67782725
14MP0001666_abnormal_nutrient_absorption2.38975234
15MP0003705_abnormal_hypodermis_morpholog2.37174159
16MP0004215_abnormal_myocardial_fiber2.25527446
17MP0008877_abnormal_DNA_methylation2.23802062
18MP0003646_muscle_fatigue2.14287185
19MP0004957_abnormal_blastocyst_morpholog2.12954915
20MP0003111_abnormal_nucleus_morphology2.11679694
21MP0002396_abnormal_hematopoietic_system2.10353820
22MP0005083_abnormal_biliary_tract2.06699263
23MP0000609_abnormal_liver_physiology2.05370611
24MP0010352_gastrointestinal_tract_polyps2.02186482
25MP0003806_abnormal_nucleotide_metabolis1.99839536
26MP0001849_ear_inflammation1.95879892
27MP0005332_abnormal_amino_acid1.92225347
28MP0002166_altered_tumor_susceptibility1.91322247
29MP0002118_abnormal_lipid_homeostasis1.89468872
30MP0003077_abnormal_cell_cycle1.88359226
31MP0009840_abnormal_foam_cell1.86576783
32MP0008058_abnormal_DNA_repair1.81315048
33MP0000749_muscle_degeneration1.81238102
34MP0003195_calcinosis1.76922100
35MP0004484_altered_response_of1.75445143
36MP0003693_abnormal_embryo_hatching1.74500131
37MP0003868_abnormal_feces_composition1.72030463
38MP0004381_abnormal_hair_follicle1.70818580
39MP0009697_abnormal_copulation1.69278962
40MP0003191_abnormal_cellular_cholesterol1.69208591
41MP0005075_abnormal_melanosome_morpholog1.63954002
42MP0008775_abnormal_heart_ventricle1.63602980
43MP0000372_irregular_coat_pigmentation1.63157068
44MP0004185_abnormal_adipocyte_glucose1.61058064
45MP0003787_abnormal_imprinting1.55242845
46MP0010307_abnormal_tumor_latency1.52630206
47MP0003221_abnormal_cardiomyocyte_apopto1.52511306
48MP0008961_abnormal_basal_metabolism1.51208129
49MP0003300_gastrointestinal_ulcer1.49715572
50MP0000569_abnormal_digit_pigmentation1.49476648
51MP0002837_dystrophic_cardiac_calcinosis1.46540900
52MP0002971_abnormal_brown_adipose1.46495813
53MP0003890_abnormal_embryonic-extraembry1.41250563
54MP0003718_maternal_effect1.40525958
55MP0001730_embryonic_growth_arrest1.40445332
56MP0004859_abnormal_synaptic_plasticity1.40136986
57MP0009780_abnormal_chondrocyte_physiolo1.38694672
58MP0005584_abnormal_enzyme/coenzyme_acti1.37872473
59MP0000015_abnormal_ear_pigmentation1.36472009
60MP0004947_skin_inflammation1.35207210
61MP0005666_abnormal_adipose_tissue1.33799849
62MP0005187_abnormal_penis_morphology1.32183041
63MP0002796_impaired_skin_barrier1.29359851
64MP0010630_abnormal_cardiac_muscle1.27883012
65MP0010678_abnormal_skin_adnexa1.27340833
66MP0005451_abnormal_body_composition1.26019695
67MP0002822_catalepsy1.20633807
68MP0002909_abnormal_adrenal_gland1.20351446
69MP0002078_abnormal_glucose_homeostasis1.18788520
70MP0005330_cardiomyopathy1.18747450
71MP0002972_abnormal_cardiac_muscle1.18506824
72MP0004019_abnormal_vitamin_homeostasis1.16394696
73MP0002106_abnormal_muscle_physiology1.16311493
74MP0003123_paternal_imprinting1.14115656
75MP0004145_abnormal_muscle_electrophysio1.13736843
76MP0000747_muscle_weakness1.13456392
77MP0005319_abnormal_enzyme/_coenzyme1.10690399
78MP0002006_tumorigenesis1.10435469
79MP0002138_abnormal_hepatobiliary_system1.07478458
80MP0001697_abnormal_embryo_size1.06984799
81MP0005266_abnormal_metabolism1.06639700
82MP0005385_cardiovascular_system_phenoty1.06527177
83MP0001544_abnormal_cardiovascular_syste1.06527177
84MP0002088_abnormal_embryonic_growth/wei1.03581316
85MP0005620_abnormal_muscle_contractility1.03552202
86MP0003984_embryonic_growth_retardation1.03115969
87MP0003880_abnormal_central_pattern1.03086468
88MP0000604_amyloidosis1.02887096
89MP0005380_embryogenesis_phenotype1.02492583
90MP0001672_abnormal_embryogenesis/_devel1.02492583
91MP0005409_darkened_coat_color1.02277508
92MP0005334_abnormal_fat_pad1.01592305
93MP0009703_decreased_birth_body0.99836953
94MP0003567_abnormal_fetal_cardiomyocyte0.99662608
95MP0002876_abnormal_thyroid_physiology0.98502942
96MP0005375_adipose_tissue_phenotype0.98288771
97MP0006138_congestive_heart_failure0.97992469
98MP0004808_abnormal_hematopoietic_stem0.96592655
99MP0009643_abnormal_urine_homeostasis0.94442552
100MP0005535_abnormal_body_temperature0.94320250
101MP0003329_amyloid_beta_deposits0.94131741
102MP0000350_abnormal_cell_proliferation0.94054997
103MP0005171_absent_coat_pigmentation0.91474698
104MP0003656_abnormal_erythrocyte_physiolo0.89684708
105MP0002086_abnormal_extraembryonic_tissu0.88620129
106MP0008569_lethality_at_weaning0.87813895
107MP0008007_abnormal_cellular_replicative0.87724326
108MP0008260_abnormal_autophagy0.86797061
109MP0005174_abnormal_tail_pigmentation0.86740438
110MP0005408_hypopigmentation0.85898253
111MP0004043_abnormal_pH_regulation0.84995782
112MP0005369_muscle_phenotype0.84832507
113MP0004885_abnormal_endolymph0.83952210
114MP0000013_abnormal_adipose_tissue0.83025325
115MP0000751_myopathy0.82765054
116MP0003879_abnormal_hair_cell0.81616788
117MP0003635_abnormal_synaptic_transmissio0.80982026
118MP0000598_abnormal_liver_morphology0.80714126
119MP0005076_abnormal_cell_differentiation0.80679553
120MP0003121_genomic_imprinting0.80598189
121MP0000003_abnormal_adipose_tissue0.80013011
122MP0005647_abnormal_sex_gland0.78213412
123MP0005464_abnormal_platelet_physiology0.77601690
124MP0002638_abnormal_pupillary_reflex0.77407752
125MP0004197_abnormal_fetal_growth/weight/0.75960020
126MP0004510_myositis0.75351029
127MP0006035_abnormal_mitochondrial_morpho0.75320449
128MP0002080_prenatal_lethality0.74648139
129MP0002269_muscular_atrophy0.74276930
130MP0003690_abnormal_glial_cell0.74044055
131MP0002877_abnormal_melanocyte_morpholog0.74020078
132MP0004264_abnormal_extraembryonic_tissu0.73029993
133MP0002102_abnormal_ear_morphology0.72967127
134MP0001188_hyperpigmentation0.72896490
135MP0005448_abnormal_energy_balance0.72543503
136MP0004085_abnormal_heartbeat0.70684360
137MP0000759_abnormal_skeletal_muscle0.70619185
138MP0008874_decreased_physiological_sensi0.69911017
139MP0004087_abnormal_muscle_fiber0.69870275
140MP0001486_abnormal_startle_reflex0.69535715
141MP0000703_abnormal_thymus_morphology0.67804508
142MP0001929_abnormal_gametogenesis0.66751113
143MP0003763_abnormal_thymus_physiology0.65903311
144MP0001661_extended_life_span0.65716935
145MP0002090_abnormal_vision0.65424591
146MP0003941_abnormal_skin_development0.65246590
147MP0002009_preneoplasia0.64739292
148MP0000383_abnormal_hair_follicle0.64698302
149MP0001944_abnormal_pancreas_morphology0.64495143
150MP0002084_abnormal_developmental_patter0.64207035
151MP0001756_abnormal_urination0.62823667
152MP0009672_abnormal_birth_weight0.61775440
153MP0000639_abnormal_adrenal_gland0.61444955
154MP0002132_abnormal_respiratory_system0.61392658
155MP0004270_analgesia0.61348516
156MP0002254_reproductive_system_inflammat0.61047500
157MP0000427_abnormal_hair_cycle0.60701958
158MP0004036_abnormal_muscle_relaxation0.60607623
159MP0001879_abnormal_lymphatic_vessel0.58953950
160MP0001765_abnormal_ion_homeostasis0.58707801
161MP0005220_abnormal_exocrine_pancreas0.58571513
162MP0009115_abnormal_fat_cell0.58506275
163MP0002970_abnormal_white_adipose0.55810584
164MP0003633_abnormal_nervous_system0.53046610
165MP0009642_abnormal_blood_homeostasis0.52852566
166MP0002063_abnormal_learning/memory/cond0.51439429
167MP0006036_abnormal_mitochondrial_physio0.50431158
168MP0003959_abnormal_lean_body0.50019019
169MP0005167_abnormal_blood-brain_barrier0.49810363
170MP0008770_decreased_survivor_rate0.49233658
171MP0003953_abnormal_hormone_level0.47821905
172MP0000920_abnormal_myelination0.47610865

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the thymus (HP:0000778)5.37232969
2Deep venous thrombosis (HP:0002625)5.21322540
3T lymphocytopenia (HP:0005403)4.84649748
4Intrahepatic cholestasis (HP:0001406)4.72192818
5Abnormality of T cell number (HP:0011839)4.52579290
6B lymphocytopenia (HP:0010976)4.19212333
7Abnormality of B cell number (HP:0010975)4.19212333
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.16060331
9Xanthomatosis (HP:0000991)4.14222127
10Papillary thyroid carcinoma (HP:0002895)3.96618873
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.96225792
12Nemaline bodies (HP:0003798)3.83204666
13Hypobetalipoproteinemia (HP:0003563)3.81644785
14Thyroiditis (HP:0100646)3.79794741
15Abnormality of the left ventricular outflow tract (HP:0011103)3.75903332
16Subaortic stenosis (HP:0001682)3.75903332
17Muscle fiber inclusion bodies (HP:0100299)3.75902113
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.64153711
19Hyperlipoproteinemia (HP:0010980)3.61597970
20Bundle branch block (HP:0011710)3.58039282
21Severe combined immunodeficiency (HP:0004430)3.57746259
22Complement deficiency (HP:0004431)3.55516995
23Calf muscle hypertrophy (HP:0008981)3.30883260
24Combined immunodeficiency (HP:0005387)3.25755449
25Muscle hypertrophy of the lower extremities (HP:0008968)3.24285830
26Ketosis (HP:0001946)3.23632759
27Epidermoid cyst (HP:0200040)3.21335420
28Hypolipoproteinemia (HP:0010981)3.18818715
29Hypoalphalipoproteinemia (HP:0003233)3.13947906
30Abnormality of the common coagulation pathway (HP:0010990)3.11734777
31Prolonged partial thromboplastin time (HP:0003645)3.10839984
32Hyperglycinemia (HP:0002154)3.06425052
33Panhypogammaglobulinemia (HP:0003139)3.04912486
34Hypochromic microcytic anemia (HP:0004840)3.04212610
35Hyperglycinuria (HP:0003108)3.01796213
36Hypoglycemic coma (HP:0001325)2.97486050
37Thyroid carcinoma (HP:0002890)2.96852697
38Sudden death (HP:0001699)2.95433542
39Hyperammonemia (HP:0001987)2.94458743
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93887673
41Abnormality of glycine metabolism (HP:0010895)2.90904000
42Abnormality of serine family amino acid metabolism (HP:0010894)2.90904000
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.89648208
44Chromsome breakage (HP:0040012)2.88794941
45Eosinophilia (HP:0001880)2.80568161
46Ketoacidosis (HP:0001993)2.74059816
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.73577029
48EMG: myopathic abnormalities (HP:0003458)2.72545207
49Pancreatic islet-cell hyperplasia (HP:0004510)2.71628983
50Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66106275
51Abnormality of chromosome stability (HP:0003220)2.65630548
52Nephroblastoma (Wilms tumor) (HP:0002667)2.65380691
53Dysmetric saccades (HP:0000641)2.64006216
54Areflexia of lower limbs (HP:0002522)2.61071707
55Biliary tract neoplasm (HP:0100574)2.56031459
56Fat malabsorption (HP:0002630)2.55584283
57Embryonal renal neoplasm (HP:0011794)2.51150882
58Erythroderma (HP:0001019)2.50710676
59Hypoproteinemia (HP:0003075)2.42458661
60Neoplasm of the adrenal gland (HP:0100631)2.42048062
61Recurrent viral infections (HP:0004429)2.41685790
62Exercise-induced myalgia (HP:0003738)2.40348973
63Hypercholesterolemia (HP:0003124)2.39632286
64Gout (HP:0001997)2.36707015
65Volvulus (HP:0002580)2.34717451
66EMG: neuropathic changes (HP:0003445)2.33697796
67Acanthocytosis (HP:0001927)2.32121971
68Hepatocellular carcinoma (HP:0001402)2.30596805
69Abnormality of complement system (HP:0005339)2.30195422
70Neoplasm of the small intestine (HP:0100833)2.29750437
71Conjugated hyperbilirubinemia (HP:0002908)2.26752236
72Cystic hygroma (HP:0000476)2.26674373
73Curly hair (HP:0002212)2.26444673
74Spastic diplegia (HP:0001264)2.25615480
75Rimmed vacuoles (HP:0003805)2.23627371
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21530818
77Progressive external ophthalmoplegia (HP:0000590)2.20621727
78Neoplasm of the adrenal cortex (HP:0100641)2.20407909
79Heart block (HP:0012722)2.19872190
80Myocardial infarction (HP:0001658)2.18419903
81Joint hemorrhage (HP:0005261)2.18130881
82Long clavicles (HP:0000890)2.17778497
83Poikilocytosis (HP:0004447)2.16654148
84Transitional cell carcinoma of the bladder (HP:0006740)2.15837320
85Abnormality of the intrinsic pathway (HP:0010989)2.15239840
86Macroorchidism (HP:0000053)2.14162072
87Pheochromocytoma (HP:0002666)2.13676388
88Abnormality of the Achilles tendon (HP:0005109)2.12780705
89Abnormal biliary tract morphology (HP:0012440)2.12073610
90Abnormality of the calf musculature (HP:0001430)2.10087702
91Acute myeloid leukemia (HP:0004808)2.10024877
92Malignant gastrointestinal tract tumors (HP:0006749)2.09801854
93Gastrointestinal carcinoma (HP:0002672)2.09801854
94Abnormality of methionine metabolism (HP:0010901)2.08960824
95Rhabdomyosarcoma (HP:0002859)2.08884666
96Skin nodule (HP:0200036)2.08826874
97Hyporeflexia of lower limbs (HP:0002600)2.08610145
98Hyperglycemia (HP:0003074)2.08196005
99Centrally nucleated skeletal muscle fibers (HP:0003687)2.08163721
100Abnormality of purine metabolism (HP:0004352)2.07498523
101Action tremor (HP:0002345)2.06918037
102Status epilepticus (HP:0002133)2.06210759
103Abnormality of the lower motor neuron (HP:0002366)2.06033525
104Bladder neoplasm (HP:0009725)2.05199511
105Bladder carcinoma (HP:0002862)2.05199511
106Ovarian neoplasm (HP:0100615)2.03839058
107Hyperbilirubinemia (HP:0002904)2.03723489
108Febrile seizures (HP:0002373)2.03160602
109Abnormality of chromosome segregation (HP:0002916)2.03105115
110Cholelithiasis (HP:0001081)2.00462928
111Granulocytopenia (HP:0001913)1.98923082
112Neonatal hypoglycemia (HP:0001998)1.98085980
113Muscle fiber splitting (HP:0003555)1.97224715
114Intention tremor (HP:0002080)1.97007307
115Exercise-induced muscle cramps (HP:0003710)1.96770155
116Hypoglycemic seizures (HP:0002173)1.95203244
117Hyperinsulinemic hypoglycemia (HP:0000825)1.94790533
118Abnormal gallbladder morphology (HP:0012437)1.93820459
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92327624
120Myoglobinuria (HP:0002913)1.92262660
121Pseudobulbar signs (HP:0002200)1.90873552
122Global brain atrophy (HP:0002283)1.90072024
123Frequent falls (HP:0002359)1.89472905
124Myelodysplasia (HP:0002863)1.89388538
125Abnormality of eosinophils (HP:0001879)1.89163934
126Impaired social interactions (HP:0000735)1.89160218
127Abnormal social behavior (HP:0012433)1.89160218
128Spontaneous abortion (HP:0005268)1.89004968
129Embryonal neoplasm (HP:0002898)1.88673286
130Rhabdomyolysis (HP:0003201)1.86402954
131Abnormality of the preputium (HP:0100587)1.86292116
132Uterine leiomyosarcoma (HP:0002891)1.84683594
133Leiomyosarcoma (HP:0100243)1.84683594
134Dyschromatopsia (HP:0007641)1.84649487
135Cafe-au-lait spot (HP:0000957)1.84052449
136Ventricular tachycardia (HP:0004756)1.83080740
137Esophageal varix (HP:0002040)1.82520942
138Breast carcinoma (HP:0003002)1.81745297
139Ependymoma (HP:0002888)1.81741007
140Right ventricular cardiomyopathy (HP:0011663)1.81497070
141Blue irides (HP:0000635)1.81423965
142Atrioventricular block (HP:0001678)1.81141413
143Neonatal onset (HP:0003623)1.80979876
144Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80027839
145Abnormality of fatty-acid metabolism (HP:0004359)1.79279600
146Neoplasm of the thyroid gland (HP:0100031)1.78866621
147Termporal pattern (HP:0011008)1.78680341
148Insidious onset (HP:0003587)1.78680341
149Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78582117
150Uterine neoplasm (HP:0010784)1.78395804
151Abnormality of the fingertips (HP:0001211)1.78181574
152Difficulty running (HP:0009046)1.77732477
153Delayed CNS myelination (HP:0002188)1.77585861
154Neuroendocrine neoplasm (HP:0100634)1.76469127
155Acute hepatic failure (HP:0006554)1.75157046
156Back pain (HP:0003418)1.75058647
157Abnormality of nucleobase metabolism (HP:0010932)1.74840722
158Abnormality of the astrocytes (HP:0100707)1.74654827
159Astrocytoma (HP:0009592)1.74654827
160Abnormality of endocrine pancreas physiology (HP:0012093)1.73490348
161Abnormality of the pancreatic islet cells (HP:0006476)1.73490348
162Symptomatic seizures (HP:0011145)1.73473618
163Abnormal atrioventricular conduction (HP:0005150)1.72449554
164Visual hallucinations (HP:0002367)1.72412719
165Hyperkalemia (HP:0002153)1.72218136
166Ventricular fibrillation (HP:0001663)1.70417571
167Medulloblastoma (HP:0002885)1.70296027
168Resting tremor (HP:0002322)1.69690300
169Gaze-evoked nystagmus (HP:0000640)1.69431290
170Sensorimotor neuropathy (HP:0007141)1.69306238
171Neoplasm of the colon (HP:0100273)1.68688981
172Insulin-resistant diabetes mellitus (HP:0000831)1.67972795
173Abnormal auditory evoked potentials (HP:0006958)1.67683741
174Tetraplegia (HP:0002445)1.67418362
175Abnormality of T cells (HP:0002843)1.66584540
176Achilles tendon contracture (HP:0001771)1.65801496
177Reticulocytosis (HP:0001923)1.64584585
178Polycythemia (HP:0001901)1.61884096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.49567163
2EIF2AK33.27684496
3TRIB32.96341954
4PKN22.76887512
5FGFR22.65005857
6MAP3K72.33449296
7PLK32.19297370
8LATS12.16965782
9RIPK12.00379747
10SIK11.99937004
11TTK1.97193167
12PTK61.96808826
13FGFR41.96134350
14KSR21.94319920
15FRK1.92241416
16MAP2K41.89073659
17BRSK21.82499659
18PLK21.78906291
19STK241.78192182
20CAMKK11.76676554
21MST41.75645267
22BRD41.73459144
23MAP3K21.68230360
24CAMKK21.65873949
25PDGFRB1.64307239
26BCKDK1.63502384
27MKNK21.62859990
28ZAK1.61573419
29TAOK31.60593604
30CAMK1G1.59309166
31CAMK1D1.57605393
32RET1.57364856
33MAP3K101.55746722
34CDC71.54661907
35EEF2K1.54110506
36DAPK21.52117547
37BUB11.45850240
38NUAK11.42562799
39FGFR31.41617716
40NLK1.40942944
41TYRO31.37197120
42SGK31.35803531
43ACVR1B1.35209169
44INSRR1.34557217
45MAP3K91.33463295
46MAP3K41.33382527
47PDGFRA1.30125180
48TSSK61.29097580
49CDK121.28322374
50PLK41.25265293
51MAPK71.22205424
52PAK61.20680593
53STK381.20336476
54CDK61.19975103
55JAK21.18507244
56ERBB31.16316569
57SRPK11.15305379
58MKNK11.13778175
59NTRK31.13095283
60PRKCH1.12319009
61NEK61.11890747
62STK41.11057230
63CSNK1G21.06702047
64OXSR10.99840130
65CSNK1A1L0.98321148
66AKT30.98083535
67IRAK20.96269596
68RAF10.95763359
69MAPK120.95173324
70STK390.94749722
71GRK60.94704383
72KSR10.94650923
73TAOK10.93216793
74ERN10.92432999
75TTN0.92214313
76WNK10.90363436
77ITK0.89418193
78PRKAA10.87295698
79RPS6KB10.87238786
80ATM0.86930927
81EPHA40.86162600
82PDK10.85567596
83STK38L0.84502911
84MARK20.80526842
85TRIM280.80497046
86MAPK110.80368457
87SCYL20.80054770
88PLK10.78221458
89NTRK20.77437186
90SGK20.77038056
91RIPK40.76653141
92WEE10.76404009
93PAK30.75310677
94PDPK10.74978644
95FGFR10.74249886
96MAP3K10.73777273
97ERBB20.72961303
98TXK0.71599907
99ATR0.71146041
100TRPM70.70617852
101CSNK1G10.70471806
102NEK10.70032376
103IRAK10.69261198
104RPS6KB20.69081879
105LMTK20.67983060
106PRKD10.67838568
107PHKG20.67123072
108PHKG10.67123072
109ALK0.66761457
110PRKAA20.65999632
111SIK20.64128885
112CAMK10.63450319
113MAP2K30.63034450
114FER0.62833262
115HIPK20.62694472
116PRKCQ0.62324158
117PIM10.62064388
118JAK10.61879501
119STK110.61704511
120TEC0.61400745
121MTOR0.61397497
122DYRK1A0.61023337
123CDK30.60455740
124CAMK40.60307371
125ERBB40.58811558
126CSNK1G30.58405308
127YES10.57675620
128EPHB10.57188463
129FLT30.56952005
130STK30.56846450
131MAP3K60.56578098
132TNIK0.56573624
133OBSCN0.56255955
134PDK40.55700305
135PDK30.55700305
136DMPK0.55378047
137BRSK10.55156027
138PBK0.55132477
139LATS20.54908231
140SGK4940.54889862
141SGK2230.54889862
142DYRK1B0.54708945
143PIK3CA0.53438013
144MAPK100.53335124
145SGK10.53095770
146CSNK1D0.52549414
147BRAF0.52259889
148MINK10.52211889
149PIK3CG0.51751426
150CSK0.51162211
151ICK0.50980688
152TYK20.50839268
153MARK30.50333806
154EIF2AK20.48829435
155CHEK10.46103128
156CCNB10.43323970
157PRPF4B0.43318632
158CSNK1E0.40201059
159MAP3K50.39743636
160PNCK0.39614402

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.58211007
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.48955092
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29391694
4Non-homologous end-joining_Homo sapiens_hsa034503.09198677
5Arginine biosynthesis_Homo sapiens_hsa002202.93360656
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54085014
7Mismatch repair_Homo sapiens_hsa034302.25706160
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14717772
9Fatty acid degradation_Homo sapiens_hsa000712.12830893
10Tryptophan metabolism_Homo sapiens_hsa003802.02075778
11Cell cycle_Homo sapiens_hsa041101.98339201
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98194741
13Butanoate metabolism_Homo sapiens_hsa006501.93832853
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.92729012
15Oocyte meiosis_Homo sapiens_hsa041141.86309175
16Complement and coagulation cascades_Homo sapiens_hsa046101.79334723
17Bile secretion_Homo sapiens_hsa049761.78118354
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77132380
19Propanoate metabolism_Homo sapiens_hsa006401.76759698
20PPAR signaling pathway_Homo sapiens_hsa033201.69548205
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59080486
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58846155
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58784339
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58365527
25Fatty acid metabolism_Homo sapiens_hsa012121.55943351
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54203619
27DNA replication_Homo sapiens_hsa030301.50033508
28Lysine degradation_Homo sapiens_hsa003101.45153199
29Inositol phosphate metabolism_Homo sapiens_hsa005621.43273888
30mRNA surveillance pathway_Homo sapiens_hsa030151.42330438
31RNA transport_Homo sapiens_hsa030131.27721844
32Regulation of autophagy_Homo sapiens_hsa041401.26882174
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22965158
34beta-Alanine metabolism_Homo sapiens_hsa004101.21411116
35ABC transporters_Homo sapiens_hsa020101.20269271
36Peroxisome_Homo sapiens_hsa041461.19642819
37Fanconi anemia pathway_Homo sapiens_hsa034601.18526470
38Caffeine metabolism_Homo sapiens_hsa002321.17155728
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11354293
40Primary immunodeficiency_Homo sapiens_hsa053401.10425100
41RNA degradation_Homo sapiens_hsa030181.08746430
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07937684
43Alcoholism_Homo sapiens_hsa050341.07740064
44Histidine metabolism_Homo sapiens_hsa003401.02997495
45Insulin resistance_Homo sapiens_hsa049311.02283819
46Pyruvate metabolism_Homo sapiens_hsa006201.01986450
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00890077
48Staphylococcus aureus infection_Homo sapiens_hsa051500.99695350
49Starch and sucrose metabolism_Homo sapiens_hsa005000.96929321
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95283594
51Glycerolipid metabolism_Homo sapiens_hsa005610.94920853
52Selenocompound metabolism_Homo sapiens_hsa004500.94891373
53Biosynthesis of amino acids_Homo sapiens_hsa012300.94169582
54Chemical carcinogenesis_Homo sapiens_hsa052040.94048515
55Carbon metabolism_Homo sapiens_hsa012000.92538158
56Long-term depression_Homo sapiens_hsa047300.91069139
57One carbon pool by folate_Homo sapiens_hsa006700.90287988
58Phenylalanine metabolism_Homo sapiens_hsa003600.89918105
59Platelet activation_Homo sapiens_hsa046110.86646436
60Type II diabetes mellitus_Homo sapiens_hsa049300.86437854
61Systemic lupus erythematosus_Homo sapiens_hsa053220.84229779
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83587675
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83503896
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82750523
65Sulfur metabolism_Homo sapiens_hsa009200.82737305
66Retinol metabolism_Homo sapiens_hsa008300.82460424
67Fat digestion and absorption_Homo sapiens_hsa049750.82035677
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.81995932
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.81266895
70Dorso-ventral axis formation_Homo sapiens_hsa043200.78875059
71Glucagon signaling pathway_Homo sapiens_hsa049220.78232713
72Fatty acid biosynthesis_Homo sapiens_hsa000610.77989397
73Long-term potentiation_Homo sapiens_hsa047200.77987444
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.77365520
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74623378
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.74264728
77mTOR signaling pathway_Homo sapiens_hsa041500.73303323
78Homologous recombination_Homo sapiens_hsa034400.72839293
79Prostate cancer_Homo sapiens_hsa052150.72229471
80T cell receptor signaling pathway_Homo sapiens_hsa046600.71904171
81Chronic myeloid leukemia_Homo sapiens_hsa052200.69883054
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69602893
83Tyrosine metabolism_Homo sapiens_hsa003500.69203441
84Circadian rhythm_Homo sapiens_hsa047100.68989731
85Colorectal cancer_Homo sapiens_hsa052100.68710079
86Insulin signaling pathway_Homo sapiens_hsa049100.66528899
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.66345562
88Pentose phosphate pathway_Homo sapiens_hsa000300.65646899
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64204633
90AMPK signaling pathway_Homo sapiens_hsa041520.64138124
91Basal transcription factors_Homo sapiens_hsa030220.63712026
92Endometrial cancer_Homo sapiens_hsa052130.59595380
93Viral carcinogenesis_Homo sapiens_hsa052030.59511583
94Adherens junction_Homo sapiens_hsa045200.58703876
95Tight junction_Homo sapiens_hsa045300.57926302
96Pancreatic cancer_Homo sapiens_hsa052120.57790183
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57174847
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55900117
99Calcium signaling pathway_Homo sapiens_hsa040200.52492804
100Pancreatic secretion_Homo sapiens_hsa049720.52109699
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51620434
102FoxO signaling pathway_Homo sapiens_hsa040680.51289646
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51063912
104HIF-1 signaling pathway_Homo sapiens_hsa040660.51060668
105Gastric acid secretion_Homo sapiens_hsa049710.50992398
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50821431
107Renin secretion_Homo sapiens_hsa049240.49766326
108Renal cell carcinoma_Homo sapiens_hsa052110.48925270
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48902330
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48612000
111Salivary secretion_Homo sapiens_hsa049700.47925039
112Insulin secretion_Homo sapiens_hsa049110.47160008
113Dilated cardiomyopathy_Homo sapiens_hsa054140.46552552
114GABAergic synapse_Homo sapiens_hsa047270.45937298
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45688066
116Choline metabolism in cancer_Homo sapiens_hsa052310.45513119
117Vitamin B6 metabolism_Homo sapiens_hsa007500.45241022
118Non-small cell lung cancer_Homo sapiens_hsa052230.44948388
119B cell receptor signaling pathway_Homo sapiens_hsa046620.44805657
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44565065
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44402571
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44346374
123Estrogen signaling pathway_Homo sapiens_hsa049150.43449902
124Thyroid hormone synthesis_Homo sapiens_hsa049180.42876705
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.41975133
126Amphetamine addiction_Homo sapiens_hsa050310.41787665
127Oxytocin signaling pathway_Homo sapiens_hsa049210.41509739
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40810991
129Fatty acid elongation_Homo sapiens_hsa000620.40131048
130Glutamatergic synapse_Homo sapiens_hsa047240.40006334
131Thyroid cancer_Homo sapiens_hsa052160.37336291
132Glioma_Homo sapiens_hsa052140.35913984
133GnRH signaling pathway_Homo sapiens_hsa049120.34629139
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.34497920
135ErbB signaling pathway_Homo sapiens_hsa040120.33004668
136Dopaminergic synapse_Homo sapiens_hsa047280.31188972
137Arginine and proline metabolism_Homo sapiens_hsa003300.31073607
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30910580
139Circadian entrainment_Homo sapiens_hsa047130.30852271
140Olfactory transduction_Homo sapiens_hsa047400.30696308

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