RIPPLY3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.93336482
2daunorubicin metabolic process (GO:0044597)6.93336482
3polyketide metabolic process (GO:0030638)6.93336482
4regulation of nuclear cell cycle DNA replication (GO:0033262)5.16586119
5behavioral response to nicotine (GO:0035095)4.93840133
6somite rostral/caudal axis specification (GO:0032525)4.57687817
7kynurenine metabolic process (GO:0070189)4.32855846
8tryptophan catabolic process (GO:0006569)4.32015757
9indole-containing compound catabolic process (GO:0042436)4.32015757
10indolalkylamine catabolic process (GO:0046218)4.32015757
11aminoglycoside antibiotic metabolic process (GO:0030647)4.22693049
12cell proliferation in forebrain (GO:0021846)4.11669344
13L-fucose catabolic process (GO:0042355)4.09516915
14fucose catabolic process (GO:0019317)4.09516915
15L-fucose metabolic process (GO:0042354)4.09516915
16serotonin metabolic process (GO:0042428)4.03616416
17tryptophan metabolic process (GO:0006568)4.01966683
18natural killer cell activation involved in immune response (GO:0002323)4.00840917
19indolalkylamine metabolic process (GO:0006586)3.94799954
20primary amino compound metabolic process (GO:1901160)3.85407555
21kidney morphogenesis (GO:0060993)3.74530106
22indole-containing compound metabolic process (GO:0042430)3.67501457
23DNA deamination (GO:0045006)3.64298290
24rRNA methylation (GO:0031167)3.63240297
25negative regulation of systemic arterial blood pressure (GO:0003085)3.61921997
26GDP-mannose metabolic process (GO:0019673)3.58452891
27negative regulation of telomere maintenance (GO:0032205)3.54544954
28sulfation (GO:0051923)3.49743667
29water-soluble vitamin biosynthetic process (GO:0042364)3.43824481
30signal transduction involved in regulation of gene expression (GO:0023019)3.42668356
31cellular ketone body metabolic process (GO:0046950)3.41582249
32rRNA modification (GO:0000154)3.40876928
33histone H4-K12 acetylation (GO:0043983)3.36855917
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34218836
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.34218836
36NADH dehydrogenase complex assembly (GO:0010257)3.34218836
37somite development (GO:0061053)3.31135698
38platelet dense granule organization (GO:0060155)3.30334306
39DNA damage response, detection of DNA damage (GO:0042769)3.29434284
40regulation of telomere maintenance via telomerase (GO:0032210)3.28795747
41protein polyglutamylation (GO:0018095)3.28388208
42negative regulation of keratinocyte proliferation (GO:0010839)3.26625841
43nucleotide transmembrane transport (GO:1901679)3.26354302
44regulation of mammary gland epithelial cell proliferation (GO:0033599)3.24816867
45opioid receptor signaling pathway (GO:0038003)3.24662310
46gamma-aminobutyric acid transport (GO:0015812)3.23554033
47glandular epithelial cell differentiation (GO:0002067)3.21802776
48tRNA methylation (GO:0030488)3.17022915
49phosphatidylinositol acyl-chain remodeling (GO:0036149)3.16172285
50GPI anchor biosynthetic process (GO:0006506)3.14033435
51regulation of apoptotic process involved in morphogenesis (GO:1902337)3.12182790
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10880077
53neuronal action potential (GO:0019228)3.10105450
54peristalsis (GO:0030432)3.08819443
55amine catabolic process (GO:0009310)3.08543018
56cellular biogenic amine catabolic process (GO:0042402)3.08543018
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07323132
58ketone body metabolic process (GO:1902224)3.05934414
59proteasome assembly (GO:0043248)3.05214889
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05141019
61protein complex biogenesis (GO:0070271)3.04513786
62omega-hydroxylase P450 pathway (GO:0097267)3.04306223
63photoreceptor cell development (GO:0042461)3.04033176
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.02783627
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02783627
66signal peptide processing (GO:0006465)3.02031632
67muscle organ morphogenesis (GO:0048644)3.00804065
68cornea development in camera-type eye (GO:0061303)3.00284367
69DNA integration (GO:0015074)3.00282081
70piRNA metabolic process (GO:0034587)2.98695594
71regulation of mesoderm development (GO:2000380)2.98065199
72preassembly of GPI anchor in ER membrane (GO:0016254)2.95524942
73nucleoside transmembrane transport (GO:1901642)2.94632742
74detection of light stimulus involved in visual perception (GO:0050908)2.93068036
75detection of light stimulus involved in sensory perception (GO:0050962)2.93068036
76replication fork processing (GO:0031297)2.88603328
77negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.85937360
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.84188120
79termination of RNA polymerase III transcription (GO:0006386)2.84188120
80eye photoreceptor cell development (GO:0042462)2.83925338
81endocrine pancreas development (GO:0031018)2.83750246
82response to dietary excess (GO:0002021)2.83601436
83negative regulation of multicellular organism growth (GO:0040015)2.83351844
84adaptation of signaling pathway (GO:0023058)2.82737594
85regulation of rhodopsin mediated signaling pathway (GO:0022400)2.81871267
86negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80819852
87mitochondrial respiratory chain complex assembly (GO:0033108)2.80355798
88norepinephrine metabolic process (GO:0042415)2.79963865
89response to pheromone (GO:0019236)2.79492730
90neural tube formation (GO:0001841)2.78505839
91GPI anchor metabolic process (GO:0006505)2.78297277
92developmental pigmentation (GO:0048066)2.77962673
93regulation of collateral sprouting (GO:0048670)2.77333212
94protein-cofactor linkage (GO:0018065)2.76943247
95interferon-gamma production (GO:0032609)2.76029339
96positive regulation of DNA-dependent DNA replication (GO:2000105)2.76004769
97regulation of MHC class I biosynthetic process (GO:0045343)2.75598068
98regulation of double-strand break repair via homologous recombination (GO:0010569)2.75229258
99positive regulation of interleukin-8 secretion (GO:2000484)2.73841107
100reflex (GO:0060004)2.72410745
101cellular response to ATP (GO:0071318)2.72058885
102regulation of mitochondrial translation (GO:0070129)2.71898891
103tRNA modification (GO:0006400)2.71787077
104rhodopsin mediated signaling pathway (GO:0016056)2.71615117
105DNA replication checkpoint (GO:0000076)2.71443249
106tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70208759
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70208759
108regulation of posttranscriptional gene silencing (GO:0060147)2.69878894
109regulation of gene silencing by miRNA (GO:0060964)2.69878894
110regulation of gene silencing by RNA (GO:0060966)2.69878894
111regulation of timing of cell differentiation (GO:0048505)2.69521484
112quinone metabolic process (GO:1901661)2.69407149
113nucleoside diphosphate catabolic process (GO:0009134)2.68745396
114cerebellar Purkinje cell differentiation (GO:0021702)2.67184034
115phenol-containing compound catabolic process (GO:0019336)2.65871007
116spinal cord motor neuron differentiation (GO:0021522)2.63620149
117multicellular organism reproduction (GO:0032504)2.62735092
118regulation of type B pancreatic cell apoptotic process (GO:2000674)2.61920934
119DNA methylation involved in gamete generation (GO:0043046)2.61320052
120negative regulation of DNA-dependent DNA replication (GO:2000104)2.60861728
121intraciliary transport (GO:0042073)2.60238071
122centriole assembly (GO:0098534)2.60201355
123phosphatidylserine acyl-chain remodeling (GO:0036150)2.59872800
124epithelial cilium movement (GO:0003351)2.59640025
125regulation of development, heterochronic (GO:0040034)2.59184435
126transcription from RNA polymerase I promoter (GO:0006360)2.59105458
127behavioral response to ethanol (GO:0048149)2.58515835
128regulation of cilium movement (GO:0003352)2.58081086
129single strand break repair (GO:0000012)2.58013780
130cell differentiation in spinal cord (GO:0021515)2.57152708
131axoneme assembly (GO:0035082)2.55721851
132nephron tubule morphogenesis (GO:0072078)2.55400544
133nephron epithelium morphogenesis (GO:0072088)2.55400544
134regulation of action potential (GO:0098900)2.54858318
135primitive streak formation (GO:0090009)2.53963327
136purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.53775871
1373-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.53775871
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53456315
139regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.53234032
140positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.53234032
141negative regulation of transcription by competitive promoter binding (GO:0010944)2.52522491
142limb bud formation (GO:0060174)2.51830325
143glycoside metabolic process (GO:0016137)2.50079202
144mitochondrial DNA replication (GO:0006264)2.50033189
145forebrain neuron differentiation (GO:0021879)2.49745319
146replicative senescence (GO:0090399)2.49650967
147deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48857380
148keratinocyte development (GO:0003334)2.48742698
149regulation of response to osmotic stress (GO:0047484)2.48382902
150membrane depolarization during action potential (GO:0086010)2.48172991
151RNA methylation (GO:0001510)2.47907824
152glycerophospholipid catabolic process (GO:0046475)2.47460861
153retinal cone cell development (GO:0046549)2.46795187
154spinal cord association neuron differentiation (GO:0021527)2.46163844
155regulation of neurotransmitter uptake (GO:0051580)2.46159916
156response to hepatocyte growth factor (GO:0035728)2.46007602
157cellular response to hepatocyte growth factor stimulus (GO:0035729)2.46007602
158histone H4-K5 acetylation (GO:0043981)2.45038512
159histone H4-K8 acetylation (GO:0043982)2.45038512
160rRNA transcription (GO:0009303)2.44895478
161aromatic amino acid family catabolic process (GO:0009074)2.44820780
162negative regulation of telomerase activity (GO:0051974)2.44104479
163nonmotile primary cilium assembly (GO:0035058)2.43512690
164maturation of 5.8S rRNA (GO:0000460)2.43406412
165mannosylation (GO:0097502)2.43286630
166superoxide anion generation (GO:0042554)2.42843006
167regulation of hippo signaling (GO:0035330)2.42812765
168regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41477634
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40502262
170DNA-dependent DNA replication (GO:0006261)2.40057304
171embryonic epithelial tube formation (GO:0001838)2.39668125
172negative regulation of mast cell activation (GO:0033004)2.39136776
173negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.38749135
174transmission of nerve impulse (GO:0019226)2.38101055
175peptidyl-histidine modification (GO:0018202)2.38001652
176regulation of interleukin-8 secretion (GO:2000482)2.37897661
177cytidine deamination (GO:0009972)2.37330997
178cytidine metabolic process (GO:0046087)2.37330997
179cytidine catabolic process (GO:0006216)2.37330997
180nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.34419170
181tRNA processing (GO:0008033)2.34213907
182negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.34017398
183exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.33863130
184pseudouridine synthesis (GO:0001522)2.33553510
185respiratory chain complex IV assembly (GO:0008535)2.33458749
186cyclooxygenase pathway (GO:0019371)2.32993012
187DNA strand renaturation (GO:0000733)2.32237805
188nucleoside transport (GO:0015858)2.30522221
189diol metabolic process (GO:0034311)2.29125041
190sphingoid metabolic process (GO:0046519)2.28932011
191telomere maintenance via semi-conservative replication (GO:0032201)2.27698911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.59937013
2EZH2_22144423_ChIP-Seq_EOC_Human4.23440937
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.04206188
4ZNF274_21170338_ChIP-Seq_K562_Hela3.99644981
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.93581054
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.93581054
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.93581054
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67959718
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.50130603
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.95207904
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82934557
12IRF1_19129219_ChIP-ChIP_H3396_Human2.58511091
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50052862
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.49325939
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48092447
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.43400622
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41780007
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40138311
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.25929878
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25671753
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.20817287
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19590746
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17342508
24EWS_26573619_Chip-Seq_HEK293_Human2.16858722
25POU5F1_16153702_ChIP-ChIP_HESCs_Human2.15507709
26VDR_22108803_ChIP-Seq_LS180_Human2.12404768
27E2F7_22180533_ChIP-Seq_HELA_Human2.11683911
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08940833
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08916585
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08449599
31FUS_26573619_Chip-Seq_HEK293_Human2.05633595
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02947769
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.88442416
34P300_19829295_ChIP-Seq_ESCs_Human1.88411989
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85311223
36TAF15_26573619_Chip-Seq_HEK293_Human1.85252247
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84637241
38ER_23166858_ChIP-Seq_MCF-7_Human1.77645554
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76785584
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.75481192
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74574031
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73661100
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66147625
44IGF1R_20145208_ChIP-Seq_DFB_Human1.65636582
45NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.64844910
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63163247
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.62624690
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.59509716
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59319387
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58983061
51* REST_21632747_ChIP-Seq_MESCs_Mouse1.58111782
52TP53_22573176_ChIP-Seq_HFKS_Human1.57935375
53RNF2_27304074_Chip-Seq_NSC_Mouse1.57815545
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52990434
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52990434
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52722013
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51470193
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51456631
59STAT3_23295773_ChIP-Seq_U87_Human1.48973612
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48106466
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48050248
62FOXP3_21729870_ChIP-Seq_TREG_Human1.47019888
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47018224
64AR_25329375_ChIP-Seq_VCAP_Human1.46177943
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.45988387
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.45479827
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44235886
68BCAT_22108803_ChIP-Seq_LS180_Human1.43237183
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42194294
70SMAD4_21799915_ChIP-Seq_A2780_Human1.41907183
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41656259
72GBX2_23144817_ChIP-Seq_PC3_Human1.40615864
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.38100109
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37564976
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36878945
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.36755114
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36589252
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.36153432
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35935915
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35878406
81ZFX_18555785_Chip-Seq_ESCs_Mouse1.34290281
82TCF4_23295773_ChIP-Seq_U87_Human1.33305642
83ELK1_19687146_ChIP-ChIP_HELA_Human1.32966246
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.31864670
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.31068309
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.30729535
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.30109183
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28353705
89CBP_20019798_ChIP-Seq_JUKART_Human1.28353705
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27415536
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27245635
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27166254
93ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27099269
94SMAD1_18555785_Chip-Seq_ESCs_Mouse1.26560486
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.25892516
96FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25892516
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25247985
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25167964
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22989917
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.22274221
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.22192065
102SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21647071
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.21080498
104NANOG_19829295_ChIP-Seq_ESCs_Human1.20204766
105SOX2_19829295_ChIP-Seq_ESCs_Human1.20204766
106TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19432484
107VDR_23849224_ChIP-Seq_CD4+_Human1.18707301
108KLF4_18555785_Chip-Seq_ESCs_Mouse1.18209296
109RUNX2_22187159_ChIP-Seq_PCA_Human1.16395527
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16297699
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16204198
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15547783
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15381008
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15129390
115ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14662836
116P300_18555785_Chip-Seq_ESCs_Mouse1.13322490
117HOXB7_26014856_ChIP-Seq_BT474_Human1.13215682
118SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12849390
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12794669
120AR_21572438_ChIP-Seq_LNCaP_Human1.12594087
121* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11988363
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11377283
123NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11245928
124TCF4_22108803_ChIP-Seq_LS180_Human1.11144266
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10873676
126OCT4_18555785_Chip-Seq_ESCs_Mouse1.10613604
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.09433385
128EZH2_27294783_Chip-Seq_ESCs_Mouse1.09395634
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08580877
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08010452
131NCOR_22424771_ChIP-Seq_293T_Human1.07762977
132MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07740114
133EZH2_27294783_Chip-Seq_NPCs_Mouse1.07089630
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06804292
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06719903
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.06503991
137AR_20517297_ChIP-Seq_VCAP_Human1.06284341
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06083702
139JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05773372
140REST_18959480_ChIP-ChIP_MESCs_Mouse1.05637734
141E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05464581
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05058502
143E2F1_18555785_Chip-Seq_ESCs_Mouse1.04670375
144FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04497955
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.04365069
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04122484
147MYC_18555785_ChIP-Seq_MESCs_Mouse1.03840963
148MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03529185
149ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03003913
150TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02111606
151KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00984493
152NANOG_16153702_ChIP-ChIP_HESCs_Human1.00780469
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00626134
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99996644
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.98837289
156OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98258766
157SOX2_16153702_ChIP-ChIP_HESCs_Human0.98169913
158P53_22387025_ChIP-Seq_ESCs_Mouse0.97832623
159CTCF_18555785_Chip-Seq_ESCs_Mouse0.97772510
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97552303
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97376097
162CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96421143
163PU1_27457419_Chip-Seq_LIVER_Mouse0.93720745
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.92200642
165E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91850759
166CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91096180
167PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88476672
168* TAL1_26923725_Chip-Seq_HPCs_Mouse0.87731499
169YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87098363
170SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86659026
171MYC_18940864_ChIP-ChIP_HL60_Human0.86176577
172FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85568738
173TTF2_22483619_ChIP-Seq_HELA_Human0.85562778
174TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84065070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.21397983
2MP0000678_abnormal_parathyroid_gland3.46026827
3MP0002277_abnormal_respiratory_mucosa2.82204162
4MP0001188_hyperpigmentation2.72423865
5MP0001986_abnormal_taste_sensitivity2.70347225
6MP0000566_synostosis2.67530306
7MP0003136_yellow_coat_color2.54828395
8MP0004885_abnormal_endolymph2.44375625
9MP0005551_abnormal_eye_electrophysiolog2.42510063
10MP0005379_endocrine/exocrine_gland_phen2.41915093
11MP0002132_abnormal_respiratory_system2.38580265
12MP0005075_abnormal_melanosome_morpholog2.38388155
13MP0003646_muscle_fatigue2.35378388
14MP0008058_abnormal_DNA_repair2.35165448
15MP0001968_abnormal_touch/_nociception2.20178686
16MP0008872_abnormal_physiological_respon2.17889931
17MP0001485_abnormal_pinna_reflex2.15515561
18MP0004381_abnormal_hair_follicle2.10706010
19MP0004142_abnormal_muscle_tone2.10194644
20MP0005499_abnormal_olfactory_system2.10114849
21MP0005394_taste/olfaction_phenotype2.10114849
22MP0003890_abnormal_embryonic-extraembry2.08898767
23MP0009046_muscle_twitch2.08463766
24MP0002837_dystrophic_cardiac_calcinosis2.05762452
25MP0005171_absent_coat_pigmentation2.05084817
26MP0008875_abnormal_xenobiotic_pharmacok2.02739296
27MP0004043_abnormal_pH_regulation1.97439472
28MP0009745_abnormal_behavioral_response1.95009771
29MP0008057_abnormal_DNA_replication1.92465142
30MP0003283_abnormal_digestive_organ1.92207259
31MP0005257_abnormal_intraocular_pressure1.90545790
32MP0002163_abnormal_gland_morphology1.87752103
33MP0002272_abnormal_nervous_system1.81789849
34MP0005645_abnormal_hypothalamus_physiol1.81296188
35MP0002736_abnormal_nociception_after1.75218701
36MP0004782_abnormal_surfactant_physiolog1.74536460
37MP0003786_premature_aging1.72403673
38MP0004145_abnormal_muscle_electrophysio1.71763345
39MP0008789_abnormal_olfactory_epithelium1.71204540
40MP0003787_abnormal_imprinting1.70741734
41MP0003122_maternal_imprinting1.69409277
42MP0003195_calcinosis1.68595509
43MP0003724_increased_susceptibility_to1.63373639
44MP0004264_abnormal_extraembryonic_tissu1.61050124
45MP0000049_abnormal_middle_ear1.59784318
46MP0002693_abnormal_pancreas_physiology1.57825210
47MP0010386_abnormal_urinary_bladder1.56524078
48MP0000372_irregular_coat_pigmentation1.50467460
49MP0001486_abnormal_startle_reflex1.50300931
50MP0002938_white_spotting1.49567246
51MP0006276_abnormal_autonomic_nervous1.49527427
52MP0004133_heterotaxia1.47413499
53MP0001501_abnormal_sleep_pattern1.44860920
54MP0002877_abnormal_melanocyte_morpholog1.41616612
55MP0002638_abnormal_pupillary_reflex1.41386186
56MP0006072_abnormal_retinal_apoptosis1.41156338
57MP0002734_abnormal_mechanical_nocicepti1.40865478
58MP0000613_abnormal_salivary_gland1.40796364
59MP0002735_abnormal_chemical_nociception1.39047425
60MP0004742_abnormal_vestibular_system1.37661998
61MP0000427_abnormal_hair_cycle1.36392116
62MP0000569_abnormal_digit_pigmentation1.35356275
63MP0008995_early_reproductive_senescence1.34461909
64MP0003121_genomic_imprinting1.34067252
65MP0002234_abnormal_pharynx_morphology1.33778618
66MP0002064_seizures1.33114194
67MP0002557_abnormal_social/conspecific_i1.32294044
68MP0000778_abnormal_nervous_system1.32001902
69MP0001529_abnormal_vocalization1.31825866
70MP0002572_abnormal_emotion/affect_behav1.31526036
71MP0003183_abnormal_peptide_metabolism1.31525026
72MP0005646_abnormal_pituitary_gland1.30918986
73MP0001970_abnormal_pain_threshold1.28445524
74MP0002751_abnormal_autonomic_nervous1.25748520
75MP0003693_abnormal_embryo_hatching1.25508398
76MP0005195_abnormal_posterior_eye1.23563002
77MP0003880_abnormal_central_pattern1.22557204
78MP0001905_abnormal_dopamine_level1.22144854
79MP0008007_abnormal_cellular_replicative1.21734107
80MP0005174_abnormal_tail_pigmentation1.21360268
81MP0010368_abnormal_lymphatic_system1.21146048
82MP0005409_darkened_coat_color1.20496131
83MP0003941_abnormal_skin_development1.17988681
84MP0003937_abnormal_limbs/digits/tail_de1.17260148
85MP0002102_abnormal_ear_morphology1.16836991
86MP0002332_abnormal_exercise_endurance1.16373717
87MP0005253_abnormal_eye_physiology1.16264128
88MP0000015_abnormal_ear_pigmentation1.16000214
89MP0001270_distended_abdomen1.13842050
90MP0002160_abnormal_reproductive_system1.13657523
91MP0002138_abnormal_hepatobiliary_system1.13143739
92MP0000762_abnormal_tongue_morphology1.11655830
93MP0002733_abnormal_thermal_nociception1.09725009
94MP0002098_abnormal_vibrissa_morphology1.08652371
95MP0001944_abnormal_pancreas_morphology1.07622173
96MP0002067_abnormal_sensory_capabilities1.07411244
97MP0001440_abnormal_grooming_behavior1.07317891
98MP0000631_abnormal_neuroendocrine_gland1.06081787
99MP0005386_behavior/neurological_phenoty1.05798029
100MP0004924_abnormal_behavior1.05798029
101MP0002063_abnormal_learning/memory/cond1.05579167
102MP0002752_abnormal_somatic_nervous1.02317330
103MP0003011_delayed_dark_adaptation1.01336241
104MP0002184_abnormal_innervation1.01254460
105MP0004147_increased_porphyrin_level1.00824460
106MP0001186_pigmentation_phenotype0.99639894
107MP0001963_abnormal_hearing_physiology0.99151391
108MP0005377_hearing/vestibular/ear_phenot0.98826667
109MP0003878_abnormal_ear_physiology0.98826667
110MP0003635_abnormal_synaptic_transmissio0.94269800
111MP0002233_abnormal_nose_morphology0.93528319
112MP0010030_abnormal_orbit_morphology0.93475418
113MP0002928_abnormal_bile_duct0.92264650
114MP0000383_abnormal_hair_follicle0.92169772
115MP0001919_abnormal_reproductive_system0.92164669
116MP0005310_abnormal_salivary_gland0.91450650
117MP0001324_abnormal_eye_pigmentation0.91258908
118MP0003315_abnormal_perineum_morphology0.89503127
119MP0000026_abnormal_inner_ear0.87901734
120MP0000230_abnormal_systemic_arterial0.87705174
121MP0003137_abnormal_impulse_conducting0.87401567
122MP0003111_abnormal_nucleus_morphology0.85700644
123MP0005389_reproductive_system_phenotype0.84372855
124MP0000681_abnormal_thyroid_gland0.83452488
125MP0005671_abnormal_response_to0.82471983
126MP0002127_abnormal_cardiovascular_syste0.82293742
127MP0002254_reproductive_system_inflammat0.81806882
128MP0005084_abnormal_gallbladder_morpholo0.81402285
129MP0008877_abnormal_DNA_methylation0.80612292
130MP0005670_abnormal_white_adipose0.80265504
131MP0005187_abnormal_penis_morphology0.79387210
132MP0004215_abnormal_myocardial_fiber0.79184796
133MP0002876_abnormal_thyroid_physiology0.79161548
134MP0003638_abnormal_response/metabolism_0.78232398
135MP0010094_abnormal_chromosome_stability0.77411337
136MP0003119_abnormal_digestive_system0.74826254
137MP0002095_abnormal_skin_pigmentation0.74823076
138MP0000955_abnormal_spinal_cord0.74622072
139MP0002229_neurodegeneration0.74548427
140MP0003938_abnormal_ear_development0.73903737
141MP0002116_abnormal_craniofacial_bone0.73645275
142MP0001835_abnormal_antigen_presentation0.73463222
143MP0002148_abnormal_hypersensitivity_rea0.73331213
144MP0003698_abnormal_male_reproductive0.73271715
145MP0005391_vision/eye_phenotype0.72823950
146MP0003718_maternal_effect0.72795649
147MP0004957_abnormal_blastocyst_morpholog0.72078480
148MP0001286_abnormal_eye_development0.71720676
149MP0002177_abnormal_outer_ear0.69757676
150MP0002653_abnormal_ependyma_morphology0.69679981
151MP0008932_abnormal_embryonic_tissue0.69360212
152MP0008260_abnormal_autophagy0.68965710
153MP0001502_abnormal_circadian_rhythm0.68378781
154MP0003077_abnormal_cell_cycle0.68162952
155MP0005508_abnormal_skeleton_morphology0.67591109
156MP0001879_abnormal_lymphatic_vessel0.66891681
157MP0001293_anophthalmia0.66804757
158MP0003828_pulmonary_edema0.64029846
159MP0000490_abnormal_crypts_of0.59722474
160MP0003935_abnormal_craniofacial_develop0.59444278

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.74838529
2Aplasia/Hypoplasia of the fovea (HP:0008060)4.52283675
3Hypoplasia of the fovea (HP:0007750)4.52283675
4Congenital stationary night blindness (HP:0007642)4.09321729
5Chromsome breakage (HP:0040012)4.05831103
6Abnormality of the fovea (HP:0000493)3.78432721
7Hyperinsulinemic hypoglycemia (HP:0000825)3.73016906
8Type I transferrin isoform profile (HP:0003642)3.71319507
9Nephronophthisis (HP:0000090)3.50869814
10Type II lissencephaly (HP:0007260)3.25783570
11Symptomatic seizures (HP:0011145)3.18535048
12Osteomalacia (HP:0002749)3.13536415
13Abnormality of the renal cortex (HP:0011035)3.11707834
14Hyperventilation (HP:0002883)3.06695984
15Genetic anticipation (HP:0003743)3.03294106
16Abnormality of the renal medulla (HP:0100957)3.02635383
17Cystic liver disease (HP:0006706)2.87487263
18Intestinal atresia (HP:0011100)2.86994698
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.83929134
20Duplicated collecting system (HP:0000081)2.81591601
21Inability to walk (HP:0002540)2.78809934
22Reduced antithrombin III activity (HP:0001976)2.78321035
23Abolished electroretinogram (ERG) (HP:0000550)2.77184306
24Abnormal protein glycosylation (HP:0012346)2.75692653
25Abnormal glycosylation (HP:0012345)2.75692653
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75692653
27Abnormal protein N-linked glycosylation (HP:0012347)2.75692653
28Microvesicular hepatic steatosis (HP:0001414)2.74608231
29Decreased circulating renin level (HP:0003351)2.74422477
30Sclerocornea (HP:0000647)2.71522575
31Tubular atrophy (HP:0000092)2.71431928
32Bilateral microphthalmos (HP:0007633)2.70932983
33Abnormality of the renal collecting system (HP:0004742)2.67346036
34Meckel diverticulum (HP:0002245)2.64978053
35Keratoconus (HP:0000563)2.63135903
36Increased corneal curvature (HP:0100692)2.63135903
37Upper limb muscle weakness (HP:0003484)2.58323920
38Chronic hepatic failure (HP:0100626)2.58203152
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57893980
40Abnormality of alanine metabolism (HP:0010916)2.57893980
41Hyperalaninemia (HP:0003348)2.57893980
42Progressive cerebellar ataxia (HP:0002073)2.56487764
43Methylmalonic acidemia (HP:0002912)2.55078341
44Aplasia/Hypoplasia of the macula (HP:0008059)2.53910126
45Abnormality of calcium-phosphate metabolism (HP:0100530)2.53808036
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52912744
47Hypoglycemic seizures (HP:0002173)2.52742728
48Chorioretinal atrophy (HP:0000533)2.52725191
49Abnormality of the ileum (HP:0001549)2.52353238
50Progressive inability to walk (HP:0002505)2.47963602
51Cerebellar dysplasia (HP:0007033)2.47136088
52Furrowed tongue (HP:0000221)2.42149728
53Abnormality of the preputium (HP:0100587)2.39711175
54Rib fusion (HP:0000902)2.39383085
55Bifid tongue (HP:0010297)2.38031543
56Hyperactive renin-angiotensin system (HP:0000841)2.36929691
573-Methylglutaconic aciduria (HP:0003535)2.34027566
58Nephroblastoma (Wilms tumor) (HP:0002667)2.33906638
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32218619
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.30411289
61Congenital sensorineural hearing impairment (HP:0008527)2.25715925
62Pendular nystagmus (HP:0012043)2.24696267
63Concave nail (HP:0001598)2.24586554
64True hermaphroditism (HP:0010459)2.23890299
65Abnormal drinking behavior (HP:0030082)2.22835834
66Polydipsia (HP:0001959)2.22835834
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22565916
68Anencephaly (HP:0002323)2.21747885
69Rectal fistula (HP:0100590)2.21095363
70Rectovaginal fistula (HP:0000143)2.21095363
71Male pseudohermaphroditism (HP:0000037)2.19422994
72Gait imbalance (HP:0002141)2.18902324
73Clubbing of toes (HP:0100760)2.18302852
74Septo-optic dysplasia (HP:0100842)2.17377050
75Abnormality of the pulmonary veins (HP:0011718)2.15752019
76Decreased central vision (HP:0007663)2.15583221
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.14971595
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13856858
79Patchy hypopigmentation of hair (HP:0011365)2.13422941
80Facial cleft (HP:0002006)2.12782365
81Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12602255
82Congenital hepatic fibrosis (HP:0002612)2.12591448
83Lissencephaly (HP:0001339)2.12349818
84Hypothermia (HP:0002045)2.11969975
85Congenital primary aphakia (HP:0007707)2.11920670
86Embryonal renal neoplasm (HP:0011794)2.10476213
87Anomalous pulmonary venous return (HP:0010772)2.10034447
88Abnormality of midbrain morphology (HP:0002418)2.09844552
89Molar tooth sign on MRI (HP:0002419)2.09844552
90Aplasia/Hypoplasia affecting the retina (HP:0008061)2.07731599
91Breast hypoplasia (HP:0003187)2.07195969
92Medial flaring of the eyebrow (HP:0010747)2.06747795
93Optic nerve hypoplasia (HP:0000609)2.06593636
94Broad-based gait (HP:0002136)2.06309267
95Bile duct proliferation (HP:0001408)2.06296366
96Abnormal biliary tract physiology (HP:0012439)2.06296366
97Hyperaldosteronism (HP:0000859)2.05298685
98Aplasia/hypoplasia of the uterus (HP:0008684)2.04382410
99Pancreatic fibrosis (HP:0100732)2.02785187
100Absent thumb (HP:0009777)2.02109903
101Increased IgM level (HP:0003496)2.02109288
102Methylmalonic aciduria (HP:0012120)2.01237702
103Aplasia/Hypoplasia of the spleen (HP:0010451)2.01030419
104Congenital, generalized hypertrichosis (HP:0004540)1.99885106
105Intestinal fistula (HP:0100819)1.99185708
106Gaze-evoked nystagmus (HP:0000640)1.98399046
107Hypoplasia of the pons (HP:0012110)1.98258230
108Aplasia/Hypoplasia of the patella (HP:0006498)1.98184900
109Genital tract atresia (HP:0001827)1.97941787
110Vaginal atresia (HP:0000148)1.96753422
111Patellar aplasia (HP:0006443)1.95998246
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.95572321
113Absent/shortened dynein arms (HP:0200106)1.95572321
114Postaxial foot polydactyly (HP:0001830)1.95055967
115Birth length less than 3rd percentile (HP:0003561)1.93693738
116Vaginal fistula (HP:0004320)1.92765993
117Abnormality of chromosome stability (HP:0003220)1.91689553
118Hyperglycinuria (HP:0003108)1.90445592
119Progressive external ophthalmoplegia (HP:0000590)1.90444619
120Abnormality of DNA repair (HP:0003254)1.89734957
121Hemiparesis (HP:0001269)1.89501645
122Insulin-resistant diabetes mellitus (HP:0000831)1.89339998
123Abnormality of the pons (HP:0007361)1.88682465
124Abnormality of renin-angiotensin system (HP:0000847)1.88288798
12511 pairs of ribs (HP:0000878)1.88068341
126Hypergonadotropic hypogonadism (HP:0000815)1.87831175
127White forelock (HP:0002211)1.87601608
128Tachypnea (HP:0002789)1.86866542
129Abnormal lung lobation (HP:0002101)1.86695682
130Pancreatic cysts (HP:0001737)1.85741581
131Cheilitis (HP:0100825)1.85234664
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84650209
133Abnormal ciliary motility (HP:0012262)1.84514944
134Renal cortical cysts (HP:0000803)1.84432772
135Atelectasis (HP:0100750)1.84082619
136Mitochondrial inheritance (HP:0001427)1.84021404
137Polyuria (HP:0000103)1.84015441
138Bone marrow hypocellularity (HP:0005528)1.83983172
139Aganglionic megacolon (HP:0002251)1.83723965
140Acute necrotizing encephalopathy (HP:0006965)1.83543008
141Increased CSF lactate (HP:0002490)1.82946424
142Short tibia (HP:0005736)1.81156996
143Confusion (HP:0001289)1.80838120
144Optic disc pallor (HP:0000543)1.80629253
145Nasolacrimal duct obstruction (HP:0000579)1.78941855
146Focal motor seizures (HP:0011153)1.78360612
147Large for gestational age (HP:0001520)1.78083386
148Asplenia (HP:0001746)1.77236877
149Protruding tongue (HP:0010808)1.77232789
150Small intestinal stenosis (HP:0012848)1.75963434
151Duodenal stenosis (HP:0100867)1.75963434
152Hyperkalemia (HP:0002153)1.75923882
153Agitation (HP:0000713)1.73328526
154Abnormal rod and cone electroretinograms (HP:0008323)1.72740965
155Duplication of thumb phalanx (HP:0009942)1.71536562
156Abnormality of the carotid arteries (HP:0005344)1.71435653
157Anophthalmia (HP:0000528)1.71357689
158Short middle phalanx of the 5th finger (HP:0004220)1.71086610
159Nephrogenic diabetes insipidus (HP:0009806)1.70495992
160Tubulointerstitial fibrosis (HP:0005576)1.70488923
161Hepatoblastoma (HP:0002884)1.70023815
162Triphalangeal thumb (HP:0001199)1.69186746
163Abnormality of the duodenum (HP:0002246)1.68295689
164Oligohydramnios (HP:0001562)1.68017501
165Stomach cancer (HP:0012126)1.67876086
166Aplastic anemia (HP:0001915)1.67473623
167Visual hallucinations (HP:0002367)1.66471709
168Shawl scrotum (HP:0000049)1.66064848
169Attenuation of retinal blood vessels (HP:0007843)1.65893157
170Chronic bronchitis (HP:0004469)1.65849566
171Type 2 muscle fiber atrophy (HP:0003554)1.65683380
172Submucous cleft hard palate (HP:0000176)1.64806325
173Sparse eyelashes (HP:0000653)1.63776538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.97296402
2INSRR3.58591853
3IRAK33.57596765
4STK163.29711025
5GRK13.05087714
6ADRBK22.94458933
7ZAK2.63362060
8NUAK12.38616961
9MAPK152.37976500
10IRAK42.35649813
11TNIK2.24115161
12GRK72.06320059
13ACVR1B2.06131687
14CDK122.05626771
15PASK2.04813470
16MAP4K22.03785611
17TIE12.00982174
18MKNK22.00176428
19GRK51.95240907
20EIF2AK21.94640534
21EPHA21.94369825
22PNCK1.84296319
23SRPK11.75910844
24AKT31.75675815
25PLK41.70046580
26CASK1.63933378
27MKNK11.61085444
28MAP3K41.59866921
29HIPK21.53719610
30TGFBR21.52393027
31SIK21.49259454
32IRAK11.47692085
33EIF2AK31.47446050
34VRK11.44806535
35NLK1.34338115
36WNK31.33127520
37YES11.32192402
38MUSK1.31742950
39BCKDK1.28475894
40BMPR1B1.27705225
41STK391.27461086
42TTK1.22446833
43MARK11.21293770
44IRAK21.15881934
45MAPK71.12789446
46OXSR11.12112916
47KDR1.09989642
48DAPK21.09269118
49BMPR21.07486525
50TAF11.07391782
51TLK11.07249059
52NEK61.04937667
53PRKCG1.01598209
54TAOK30.99767286
55TEC0.98373240
56DYRK30.97827501
57CDK70.95825960
58TXK0.94011735
59PLK20.91623806
60DYRK20.91352346
61VRK20.89880459
62PAK30.89415332
63IKBKB0.89260868
64PTK2B0.87082099
65TGFBR10.86313676
66NEK20.86259812
67CDK30.83567537
68MAP3K140.79668651
69CSNK1G20.78327431
70WEE10.77360553
71PRPF4B0.76376015
72MAPKAPK30.75768366
73NTRK20.74683277
74CHEK20.74080049
75BUB10.73058032
76CDK80.72579982
77PLK30.71840453
78CHUK0.71815941
79ERN10.70987010
80MAP2K70.70242382
81BRSK20.69897255
82CAMKK20.69018694
83CSNK1G30.68845680
84EPHB20.66885408
85PLK10.66326063
86BCR0.66268395
87GRK60.65856495
88PRKD20.65176379
89BRD40.63632251
90CSNK1G10.63316988
91EIF2AK10.60793877
92CSF1R0.60286779
93TNK20.59981869
94CSNK1A1L0.59437138
95CSK0.58269453
96CAMK2A0.57939325
97MAPKAPK50.57866437
98RPS6KA50.57604450
99FLT30.57349541
100MAPK130.57032399
101STK38L0.56199920
102PRKCH0.56189951
103IKBKE0.55859485
104DYRK1A0.55127343
105TRIM280.55045732
106PIK3CA0.54894162
107CAMK10.54699648
108ADRBK10.54008498
109NTRK30.53898633
110AURKA0.52490523
111ATR0.51844152
112NME10.51553178
113WNK10.51507182
114FGFR20.51424687
115MAP2K40.50932859
116ITK0.50018189
117EPHA30.50016962
118PDK20.49956783
119PINK10.49652047
120LATS10.49646070
121MAP2K60.49594799
122PRKCI0.47746431
123PRKACA0.46580043
124CAMK40.46246477
125PRKCQ0.44643211
126EPHA40.44345380
127PRKCE0.43819869
128BTK0.43285120
129CSNK1A10.42366193
130PHKG10.41312895
131PHKG20.41312895
132MATK0.41200293
133PRKCZ0.41047202
134PRKG20.40357500
135STK110.39415428
136ATM0.38899778
137CAMK1G0.38329732
138LYN0.37965118
139SGK2230.36132453
140SGK4940.36132453
141PBK0.34730555
142SIK30.34491680
143STK30.34321388
144CLK10.33505447
145WNK40.33478162
146CSNK1D0.33460911
147RPS6KA60.33289798
148DYRK1B0.31715207
149PRKCD0.30892892
150CDC42BPA0.30722787
151SGK20.30383412
152JAK30.29642926
153ERBB30.29506385
154AURKB0.29073561
155BRAF0.28993677
156MAP2K10.28889843
157CSNK2A10.28729064
158PIK3CG0.28363312
159IGF1R0.27710845

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.29549479
2Protein export_Homo sapiens_hsa030603.68920370
3Selenocompound metabolism_Homo sapiens_hsa004502.80651534
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.74275193
5Fanconi anemia pathway_Homo sapiens_hsa034602.66535292
6Homologous recombination_Homo sapiens_hsa034402.42485122
7RNA polymerase_Homo sapiens_hsa030202.39649016
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38140503
9Nitrogen metabolism_Homo sapiens_hsa009102.14001493
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09994659
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06128966
12Arachidonic acid metabolism_Homo sapiens_hsa005902.05899395
13Caffeine metabolism_Homo sapiens_hsa002321.99764840
14Mismatch repair_Homo sapiens_hsa034301.98621506
15Butanoate metabolism_Homo sapiens_hsa006501.92946876
16DNA replication_Homo sapiens_hsa030301.90586597
17Nicotine addiction_Homo sapiens_hsa050331.89464046
18Non-homologous end-joining_Homo sapiens_hsa034501.87191224
19Tryptophan metabolism_Homo sapiens_hsa003801.83185218
20Basal transcription factors_Homo sapiens_hsa030221.80990398
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79053656
22Other glycan degradation_Homo sapiens_hsa005111.75939135
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69475521
24Ribosome_Homo sapiens_hsa030101.63334589
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54875542
26Linoleic acid metabolism_Homo sapiens_hsa005911.53462877
27Vitamin B6 metabolism_Homo sapiens_hsa007501.48515795
28Pyrimidine metabolism_Homo sapiens_hsa002401.48202480
29Sphingolipid metabolism_Homo sapiens_hsa006001.42910843
30Base excision repair_Homo sapiens_hsa034101.42759340
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41734145
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41425688
33Proteasome_Homo sapiens_hsa030501.36814550
34Spliceosome_Homo sapiens_hsa030401.36152111
35Nucleotide excision repair_Homo sapiens_hsa034201.32999178
36Morphine addiction_Homo sapiens_hsa050321.32527901
37RNA degradation_Homo sapiens_hsa030181.32436639
38Autoimmune thyroid disease_Homo sapiens_hsa053201.28021467
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27902517
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.27639132
41Regulation of autophagy_Homo sapiens_hsa041401.23796107
42Cardiac muscle contraction_Homo sapiens_hsa042601.20343340
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20166329
44Taste transduction_Homo sapiens_hsa047421.16244344
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16011770
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.14795766
47Allograft rejection_Homo sapiens_hsa053301.14562212
48Purine metabolism_Homo sapiens_hsa002301.14379958
49Propanoate metabolism_Homo sapiens_hsa006401.14069855
50Ether lipid metabolism_Homo sapiens_hsa005651.11976917
51Chemical carcinogenesis_Homo sapiens_hsa052041.11271306
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.10299684
53Glutamatergic synapse_Homo sapiens_hsa047241.09838990
54Basal cell carcinoma_Homo sapiens_hsa052171.08293972
55Graft-versus-host disease_Homo sapiens_hsa053321.07062162
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.06774870
57Olfactory transduction_Homo sapiens_hsa047401.04469275
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03741863
59Circadian entrainment_Homo sapiens_hsa047131.03387284
60Hedgehog signaling pathway_Homo sapiens_hsa043401.01292876
61GABAergic synapse_Homo sapiens_hsa047271.01225705
62Peroxisome_Homo sapiens_hsa041460.98405734
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96170021
64Type I diabetes mellitus_Homo sapiens_hsa049400.95305408
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95275292
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95074275
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93552797
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.92248204
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91367268
70Glycerolipid metabolism_Homo sapiens_hsa005610.90153415
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89479226
72Phototransduction_Homo sapiens_hsa047440.89020543
73Primary immunodeficiency_Homo sapiens_hsa053400.85982160
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83892328
75Oxidative phosphorylation_Homo sapiens_hsa001900.83604171
76Hematopoietic cell lineage_Homo sapiens_hsa046400.82989345
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82514416
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80039762
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79785381
80Serotonergic synapse_Homo sapiens_hsa047260.78951858
81beta-Alanine metabolism_Homo sapiens_hsa004100.78687015
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78546159
83p53 signaling pathway_Homo sapiens_hsa041150.77297885
84Cell cycle_Homo sapiens_hsa041100.77191096
85One carbon pool by folate_Homo sapiens_hsa006700.76428454
86Folate biosynthesis_Homo sapiens_hsa007900.75335176
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73880751
88Histidine metabolism_Homo sapiens_hsa003400.71475558
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71316130
90mRNA surveillance pathway_Homo sapiens_hsa030150.71006496
91Long-term depression_Homo sapiens_hsa047300.70910507
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.70345551
93Calcium signaling pathway_Homo sapiens_hsa040200.70112509
94Herpes simplex infection_Homo sapiens_hsa051680.69723837
95RNA transport_Homo sapiens_hsa030130.68344959
96Dopaminergic synapse_Homo sapiens_hsa047280.63060336
97Circadian rhythm_Homo sapiens_hsa047100.62946833
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62900687
99Ovarian steroidogenesis_Homo sapiens_hsa049130.62605162
100Measles_Homo sapiens_hsa051620.61869339
101Vibrio cholerae infection_Homo sapiens_hsa051100.60950673
102Steroid biosynthesis_Homo sapiens_hsa001000.60763939
103Asthma_Homo sapiens_hsa053100.59208220
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58933545
105Huntingtons disease_Homo sapiens_hsa050160.58351497
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58250086
107Galactose metabolism_Homo sapiens_hsa000520.57355981
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56798585
109Insulin secretion_Homo sapiens_hsa049110.56672616
110Fat digestion and absorption_Homo sapiens_hsa049750.56622501
111Salivary secretion_Homo sapiens_hsa049700.56497841
112Mineral absorption_Homo sapiens_hsa049780.54669438
113Rheumatoid arthritis_Homo sapiens_hsa053230.54563930
114ABC transporters_Homo sapiens_hsa020100.54041144
115Sulfur metabolism_Homo sapiens_hsa009200.53486292
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.51972400
117Retinol metabolism_Homo sapiens_hsa008300.49346044
118Notch signaling pathway_Homo sapiens_hsa043300.47822893
119Dorso-ventral axis formation_Homo sapiens_hsa043200.47004038
120Cocaine addiction_Homo sapiens_hsa050300.46837742
121N-Glycan biosynthesis_Homo sapiens_hsa005100.46631171
122Parkinsons disease_Homo sapiens_hsa050120.42826257
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42362766
124Cholinergic synapse_Homo sapiens_hsa047250.41118338
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.40150256
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.39618102
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39152621
128Metabolic pathways_Homo sapiens_hsa011000.38303000
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38046823
130Sulfur relay system_Homo sapiens_hsa041220.37874740
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37212271
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37112405
133Alzheimers disease_Homo sapiens_hsa050100.36342264
134Malaria_Homo sapiens_hsa051440.35969659
135African trypanosomiasis_Homo sapiens_hsa051430.34420383
136cAMP signaling pathway_Homo sapiens_hsa040240.32792262
137Legionellosis_Homo sapiens_hsa051340.32741254
138Collecting duct acid secretion_Homo sapiens_hsa049660.32414442
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30338505
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30316247
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30207481
142Fructose and mannose metabolism_Homo sapiens_hsa000510.30157644
143Epstein-Barr virus infection_Homo sapiens_hsa051690.28619751
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28613883
145Lysosome_Homo sapiens_hsa041420.28195530
146Vitamin digestion and absorption_Homo sapiens_hsa049770.28172954
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27999244
148Pertussis_Homo sapiens_hsa051330.27681581
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27539779
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25794075
151Alcoholism_Homo sapiens_hsa050340.25357472

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