RIOK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.36716252
2chromatin remodeling at centromere (GO:0031055)4.89728438
3CENP-A containing nucleosome assembly (GO:0034080)4.85773804
4DNA double-strand break processing (GO:0000729)4.72708593
5ribosome assembly (GO:0042255)4.35720425
6mitotic metaphase plate congression (GO:0007080)4.07774216
7histone exchange (GO:0043486)4.04449592
8DNA replication-dependent nucleosome assembly (GO:0006335)3.91331183
9DNA replication-dependent nucleosome organization (GO:0034723)3.91331183
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83274158
11DNA replication-independent nucleosome assembly (GO:0006336)3.80893967
12DNA replication-independent nucleosome organization (GO:0034724)3.80893967
13DNA replication checkpoint (GO:0000076)3.80710606
14protein localization to kinetochore (GO:0034501)3.79024348
15cullin deneddylation (GO:0010388)3.77996603
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.77861134
17negative regulation of DNA-dependent DNA replication (GO:2000104)3.67887954
18replication fork processing (GO:0031297)3.67794695
19metaphase plate congression (GO:0051310)3.66443349
20regulation of mitotic spindle checkpoint (GO:1903504)3.64756999
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.64756999
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64654413
23maturation of 5.8S rRNA (GO:0000460)3.62630252
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62165470
25DNA catabolic process, exonucleolytic (GO:0000738)3.60738832
26spindle checkpoint (GO:0031577)3.59550207
27mitotic spindle checkpoint (GO:0071174)3.54301500
28establishment of integrated proviral latency (GO:0075713)3.51251510
29protein deneddylation (GO:0000338)3.49739463
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43051320
31negative regulation of ligase activity (GO:0051352)3.43051320
32sister chromatid segregation (GO:0000819)3.37381664
33IMP biosynthetic process (GO:0006188)3.36950574
34negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36561284
35negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36561284
36negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36561284
37negative regulation of mitotic sister chromatid separation (GO:2000816)3.36561284
38negative regulation of sister chromatid segregation (GO:0033046)3.36561284
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35305542
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.33953020
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.33953020
42mitochondrial RNA metabolic process (GO:0000959)3.31445141
43negative regulation of chromosome segregation (GO:0051985)3.29992775
44mitotic sister chromatid segregation (GO:0000070)3.29679367
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26303928
46DNA ligation (GO:0006266)3.25666257
47protein neddylation (GO:0045116)3.23734556
48telomere maintenance via semi-conservative replication (GO:0032201)3.22980042
49purine nucleobase biosynthetic process (GO:0009113)3.21925096
50histone mRNA metabolic process (GO:0008334)3.21879989
51DNA strand elongation involved in DNA replication (GO:0006271)3.21759423
52kinetochore organization (GO:0051383)3.20585437
53resolution of meiotic recombination intermediates (GO:0000712)3.20428802
54respiratory chain complex IV assembly (GO:0008535)3.19938243
55mitotic spindle assembly checkpoint (GO:0007094)3.19934242
56spindle assembly checkpoint (GO:0071173)3.19926408
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19773526
58regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19716550
59regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19716550
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18874707
61attachment of spindle microtubules to kinetochore (GO:0008608)3.18551170
62postreplication repair (GO:0006301)3.13701748
63positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12507072
64mitotic recombination (GO:0006312)3.11128092
65regulation of mitotic sister chromatid segregation (GO:0033047)3.10900898
66regulation of sister chromatid segregation (GO:0033045)3.10900898
67regulation of mitotic sister chromatid separation (GO:0010965)3.10900898
68transcription elongation from RNA polymerase III promoter (GO:0006385)3.07939910
69termination of RNA polymerase III transcription (GO:0006386)3.07939910
70regulation of centriole replication (GO:0046599)3.07919901
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07605931
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07605931
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07605931
74DNA strand elongation (GO:0022616)3.06659704
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05844784
76negative regulation of DNA recombination (GO:0045910)3.04742584
77protein K6-linked ubiquitination (GO:0085020)3.03491224
78kinetochore assembly (GO:0051382)3.02074692
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01861524
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01861524
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01533896
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01533896
83regulation of cellular amino acid metabolic process (GO:0006521)3.01348598
84regulation of helicase activity (GO:0051095)3.01304602
85synapsis (GO:0007129)3.00989491
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00814349
87establishment of chromosome localization (GO:0051303)2.99406524
88positive regulation of ligase activity (GO:0051351)2.98776524
89nucleobase biosynthetic process (GO:0046112)2.97710597
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.95807819
91signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95807819
92pseudouridine synthesis (GO:0001522)2.95227318
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.94271325
94protein localization to chromosome, centromeric region (GO:0071459)2.94119427
95establishment of protein localization to mitochondrial membrane (GO:0090151)2.92984724
96positive regulation of histone H3-K4 methylation (GO:0051571)2.92777384
97rRNA modification (GO:0000154)2.91654006
98mitotic G2/M transition checkpoint (GO:0044818)2.91165853
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90679673
100telomere maintenance via recombination (GO:0000722)2.90215098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.83225823
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.82745614
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.04460342
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.63864577
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62282730
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56457405
7ELK1_19687146_ChIP-ChIP_HELA_Human2.97809751
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84527595
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72519109
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.66354734
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.64464544
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62598543
13* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59411369
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.56519004
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.51656347
16VDR_23849224_ChIP-Seq_CD4+_Human2.50607174
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46045363
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33968184
19* FOXP3_21729870_ChIP-Seq_TREG_Human2.18178751
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15614576
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.14470742
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.13838544
23ZNF274_21170338_ChIP-Seq_K562_Hela2.11980714
24* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.07219487
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01035091
26EWS_26573619_Chip-Seq_HEK293_Human1.98112644
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94620099
28AR_21909140_ChIP-Seq_LNCAP_Human1.79410625
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77842799
30DCP1A_22483619_ChIP-Seq_HELA_Human1.76437207
31FUS_26573619_Chip-Seq_HEK293_Human1.76264360
32* SRF_21415370_ChIP-Seq_HL-1_Mouse1.73603775
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72583513
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.72358220
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66910839
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66238058
37* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65013587
38MYC_18940864_ChIP-ChIP_HL60_Human1.64990645
39VDR_22108803_ChIP-Seq_LS180_Human1.63891700
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.61773675
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58704743
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57646675
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56575266
44GABP_19822575_ChIP-Seq_HepG2_Human1.53362800
45TTF2_22483619_ChIP-Seq_HELA_Human1.52864048
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52605092
47* E2F1_21310950_ChIP-Seq_MCF-7_Human1.46647303
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42932603
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41416712
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40692544
51* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40588997
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34648454
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31767374
54IGF1R_20145208_ChIP-Seq_DFB_Human1.31483619
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29880643
56TAF15_26573619_Chip-Seq_HEK293_Human1.26518868
57* P300_19829295_ChIP-Seq_ESCs_Human1.25917890
58* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24338742
59* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23479002
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22277791
61* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21841442
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20956916
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20264369
64* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19902077
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.16759301
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13851222
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12476982
68IRF1_19129219_ChIP-ChIP_H3396_Human1.08833816
69XRN2_22483619_ChIP-Seq_HELA_Human1.08673087
70* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04709131
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.03585068
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02652111
73* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99989008
74EZH2_27294783_Chip-Seq_NPCs_Mouse0.99817769
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99183323
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98955956
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98231421
78TP63_19390658_ChIP-ChIP_HaCaT_Human0.98142359
79ELK1_22589737_ChIP-Seq_MCF10A_Human0.98083917
80SOX2_16153702_ChIP-ChIP_HESCs_Human0.96973195
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95999250
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92522371
83TP53_22573176_ChIP-Seq_HFKS_Human0.91382775
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89933649
85ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89167974
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88898031
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.86791426
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86032438
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86005335
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85397740
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85006455
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84540584
93NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82967077
94* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80855872
95* SALL4_22934838_ChIP-ChIP_CD34+_Human0.80145665
96KDM5A_27292631_Chip-Seq_BREAST_Human0.79677971
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79251811
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.79039361
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78975392
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78432577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.64173387
2MP0008058_abnormal_DNA_repair4.47256951
3MP0008057_abnormal_DNA_replication4.43892096
4MP0003693_abnormal_embryo_hatching3.96143641
5MP0008877_abnormal_DNA_methylation3.68991592
6MP0004957_abnormal_blastocyst_morpholog3.42618313
7MP0003111_abnormal_nucleus_morphology3.14307991
8MP0003718_maternal_effect3.09083480
9MP0003077_abnormal_cell_cycle3.03292466
10MP0008932_abnormal_embryonic_tissue2.45001889
11MP0000372_irregular_coat_pigmentation2.39751419
12MP0002102_abnormal_ear_morphology2.32820669
13MP0009697_abnormal_copulation2.28230501
14MP0003786_premature_aging2.27737363
15MP0005084_abnormal_gallbladder_morpholo2.13511767
16MP0008007_abnormal_cellular_replicative2.13163660
17MP0006292_abnormal_olfactory_placode1.95138751
18MP0003890_abnormal_embryonic-extraembry1.91669113
19MP0002938_white_spotting1.82236692
20MP0001293_anophthalmia1.80359033
21MP0001529_abnormal_vocalization1.79354120
22MP0006072_abnormal_retinal_apoptosis1.76103158
23MP0003567_abnormal_fetal_cardiomyocyte1.70519696
24MP0003186_abnormal_redox_activity1.68971390
25MP0003941_abnormal_skin_development1.65156583
26MP0008789_abnormal_olfactory_epithelium1.58636550
27MP0008995_early_reproductive_senescence1.54107912
28MP0003806_abnormal_nucleotide_metabolis1.50491446
29MP0006035_abnormal_mitochondrial_morpho1.44964641
30MP0006054_spinal_hemorrhage1.44825379
31MP0003121_genomic_imprinting1.43051153
32MP0006036_abnormal_mitochondrial_physio1.38048429
33MP0005075_abnormal_melanosome_morpholog1.36292990
34MP0001929_abnormal_gametogenesis1.32637011
35MP0002210_abnormal_sex_determination1.30688358
36MP0001764_abnormal_homeostasis1.27343721
37MP0001697_abnormal_embryo_size1.25951375
38MP0003937_abnormal_limbs/digits/tail_de1.25546147
39MP0005253_abnormal_eye_physiology1.24933104
40MP0001672_abnormal_embryogenesis/_devel1.24209117
41MP0005380_embryogenesis_phenotype1.24209117
42MP0001730_embryonic_growth_arrest1.21923400
43MP0000350_abnormal_cell_proliferation1.20338287
44MP0003011_delayed_dark_adaptation1.19516279
45MP0004133_heterotaxia1.14956417
46MP0004147_increased_porphyrin_level1.13897491
47MP0000653_abnormal_sex_gland1.12206996
48MP0001145_abnormal_male_reproductive1.11116179
49MP0002160_abnormal_reproductive_system1.07381524
50MP0004215_abnormal_myocardial_fiber1.06122871
51MP0005395_other_phenotype1.05913477
52MP0002084_abnormal_developmental_patter1.05753580
53MP0010307_abnormal_tumor_latency1.03944062
54MP0002088_abnormal_embryonic_growth/wei1.00483850
55MP0003984_embryonic_growth_retardation0.98893311
56MP0001286_abnormal_eye_development0.98686361
57MP0003136_yellow_coat_color0.98671538
58MP0005645_abnormal_hypothalamus_physiol0.97607709
59MP0002751_abnormal_autonomic_nervous0.97542275
60MP0005367_renal/urinary_system_phenotyp0.94451973
61MP0000516_abnormal_urinary_system0.94451973
62MP0000358_abnormal_cell_content/0.93866951
63MP0001119_abnormal_female_reproductive0.92039200
64MP0001188_hyperpigmentation0.90778419
65MP0002085_abnormal_embryonic_tissue0.90707237
66MP0002234_abnormal_pharynx_morphology0.90687614
67MP0002233_abnormal_nose_morphology0.90437496
68MP0005551_abnormal_eye_electrophysiolog0.89346847
69MP0000569_abnormal_digit_pigmentation0.88765726
70MP0003195_calcinosis0.87964255
71MP0005499_abnormal_olfactory_system0.87918581
72MP0005394_taste/olfaction_phenotype0.87918581
73MP0002095_abnormal_skin_pigmentation0.87795263
74MP0002163_abnormal_gland_morphology0.86711501
75MP0002254_reproductive_system_inflammat0.86383529
76MP0003221_abnormal_cardiomyocyte_apopto0.86234117
77MP0002837_dystrophic_cardiac_calcinosis0.85878683
78MP0002080_prenatal_lethality0.83951873
79MP0000313_abnormal_cell_death0.83404008
80MP0003119_abnormal_digestive_system0.83130248
81MP0002736_abnormal_nociception_after0.81865952
82MP0008872_abnormal_physiological_respon0.81472654
83MP0000647_abnormal_sebaceous_gland0.80681083
84MP0000427_abnormal_hair_cycle0.80083788
85MP0001984_abnormal_olfaction0.78913425
86MP0002090_abnormal_vision0.78355157
87MP0000631_abnormal_neuroendocrine_gland0.76806795
88MP0005391_vision/eye_phenotype0.75861888
89MP0010030_abnormal_orbit_morphology0.74791236
90MP0003698_abnormal_male_reproductive0.74035975
91MP0003943_abnormal_hepatobiliary_system0.72713423
92MP0002019_abnormal_tumor_incidence0.71620341
93MP0004197_abnormal_fetal_growth/weight/0.70926280
94MP0005389_reproductive_system_phenotype0.69423722
95MP0005220_abnormal_exocrine_pancreas0.68050043
96MP0001324_abnormal_eye_pigmentation0.68045185
97MP0003755_abnormal_palate_morphology0.64859717
98MP0005408_hypopigmentation0.63201245
99MP0005266_abnormal_metabolism0.61605647
100MP0001177_atelectasis0.60700319

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.37969293
2Abnormality of chromosome stability (HP:0003220)3.31142497
3Abnormality of the labia minora (HP:0012880)3.27636357
4Methylmalonic acidemia (HP:0002912)3.23665398
5Meckel diverticulum (HP:0002245)3.20980364
6Chromsome breakage (HP:0040012)3.14819999
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.11144438
8Acute necrotizing encephalopathy (HP:0006965)3.09314106
9Abnormality of the ileum (HP:0001549)3.06621522
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02852043
11Acute encephalopathy (HP:0006846)2.99846120
12Abnormality of the preputium (HP:0100587)2.94083357
13Increased CSF lactate (HP:0002490)2.85748475
14Progressive macrocephaly (HP:0004481)2.79912423
15Abnormality of B cell number (HP:0010975)2.76259364
16Mitochondrial inheritance (HP:0001427)2.71313665
17Abnormality of methionine metabolism (HP:0010901)2.69369643
18Volvulus (HP:0002580)2.68166590
19Abnormal mitochondria in muscle tissue (HP:0008316)2.67470549
20Duodenal stenosis (HP:0100867)2.59958926
21Small intestinal stenosis (HP:0012848)2.59958926
22Hepatocellular necrosis (HP:0001404)2.59442970
23B lymphocytopenia (HP:0010976)2.53204250
24Increased serum lactate (HP:0002151)2.53047475
25Increased serum pyruvate (HP:0003542)2.52432346
26Methylmalonic aciduria (HP:0012120)2.52427112
27Pancreatic cysts (HP:0001737)2.50366336
28Increased hepatocellular lipid droplets (HP:0006565)2.49359570
29Hepatic necrosis (HP:0002605)2.47844614
30Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46542576
31Abnormality of alanine metabolism (HP:0010916)2.43782135
32Hyperalaninemia (HP:0003348)2.43782135
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43782135
34Type I transferrin isoform profile (HP:0003642)2.38739592
35Abnormality of serum amino acid levels (HP:0003112)2.38253311
36Abnormality of the duodenum (HP:0002246)2.36816411
37Abnormal lung lobation (HP:0002101)2.35232319
38Birth length less than 3rd percentile (HP:0003561)2.34092101
39Supernumerary spleens (HP:0009799)2.33578903
40Hyperglycinemia (HP:0002154)2.32427917
41Lipid accumulation in hepatocytes (HP:0006561)2.29783360
42Pancreatic fibrosis (HP:0100732)2.29562375
43Cerebral edema (HP:0002181)2.27602722
44Pancreatic islet-cell hyperplasia (HP:0004510)2.23560564
45Abnormality of glycolysis (HP:0004366)2.21580618
46Renal cortical cysts (HP:0000803)2.21260751
47Sloping forehead (HP:0000340)2.20713278
48Abnormality of the anterior horn cell (HP:0006802)2.19586265
49Degeneration of anterior horn cells (HP:0002398)2.19586265
503-Methylglutaconic aciduria (HP:0003535)2.18943986
51Neoplasm of the adrenal gland (HP:0100631)2.18331197
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16780738
53Abnormal protein N-linked glycosylation (HP:0012347)2.16780738
54Abnormal protein glycosylation (HP:0012346)2.16780738
55Abnormal glycosylation (HP:0012345)2.16780738
56Median cleft lip (HP:0000161)2.13946998
57Reduced antithrombin III activity (HP:0001976)2.11572755
58Lactic acidosis (HP:0003128)2.08916384
59Medulloblastoma (HP:0002885)2.05934115
60Microvesicular hepatic steatosis (HP:0001414)2.04962523
61Short tibia (HP:0005736)2.04427005
62Hypoproteinemia (HP:0003075)2.04388867
63Nephroblastoma (Wilms tumor) (HP:0002667)2.04099969
64Clubbing of toes (HP:0100760)2.02738129
65True hermaphroditism (HP:0010459)2.01912144
66Abnormality of midbrain morphology (HP:0002418)2.01412704
67Molar tooth sign on MRI (HP:0002419)2.01412704
68Neoplasm of the colon (HP:0100273)2.00509921
69Rhabdomyosarcoma (HP:0002859)1.99958431
70Medial flaring of the eyebrow (HP:0010747)1.99918467
71Abnormality of the vitamin B12 metabolism (HP:0004341)1.98111120
72Embryonal renal neoplasm (HP:0011794)1.97024352
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.95144440
74Abnormality of vitamin B metabolism (HP:0004340)1.91899434
75Abnormality of the renal cortex (HP:0011035)1.88862546
76Triphalangeal thumb (HP:0001199)1.87343722
77Sensory axonal neuropathy (HP:0003390)1.87061452
78Hypoglycemic coma (HP:0001325)1.86829762
79Gonadotropin excess (HP:0000837)1.86094794
80Neoplasm of the adrenal cortex (HP:0100641)1.86037061
81Renal Fanconi syndrome (HP:0001994)1.85923310
82Hypoplasia of the pons (HP:0012110)1.85680458
83Septo-optic dysplasia (HP:0100842)1.84224266
84Abnormality of the pons (HP:0007361)1.82811826
85Lethargy (HP:0001254)1.82460491
86Myelodysplasia (HP:0002863)1.81984000
87Stomach cancer (HP:0012126)1.81220599
88Abnormality of serine family amino acid metabolism (HP:0010894)1.79841081
89Abnormality of glycine metabolism (HP:0010895)1.79841081
90Progressive inability to walk (HP:0002505)1.79698435
91Intestinal atresia (HP:0011100)1.79524432
92Nephronophthisis (HP:0000090)1.79056739
93Combined immunodeficiency (HP:0005387)1.78887134
94Aplastic anemia (HP:0001915)1.77607990
95Thyroiditis (HP:0100646)1.77273754
96Optic disc pallor (HP:0000543)1.75999051
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75410070
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75410070
99Stenosis of the external auditory canal (HP:0000402)1.72918435
100Small hand (HP:0200055)1.72190389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.50104605
2EIF2AK33.49439800
3BUB13.32360963
4SRPK13.16737509
5MST42.82557389
6ZAK2.79869681
7TSSK62.79326421
8TTK2.64806005
9NEK12.61335502
10PLK32.44069399
11CDC72.34927205
12PBK2.31974508
13MKNK22.30672903
14NUAK12.28263801
15VRK22.22698706
16BMPR1B2.18881323
17PLK42.13350095
18MKNK12.13102480
19EIF2AK12.08401288
20VRK12.05071845
21MAP4K21.95746352
22WNK31.86858906
23BRSK21.85287483
24WEE11.77747220
25TNIK1.72323169
26ERBB31.71520626
27BCR1.69177108
28FRK1.62763135
29PLK11.44991660
30PDK21.41616855
31ACVR1B1.26262868
32PASK1.22095543
33INSRR1.15449622
34NME11.15051037
35TAF11.13227987
36STK161.11611884
37TGFBR11.10787631
38EIF2AK21.09154752
39CSNK1G11.07706912
40ATR1.05510222
41STK38L0.95781631
42PLK20.93579046
43CHEK20.88058816
44NLK0.87188839
45MAP3K120.84833374
46ADRBK20.84508578
47STK30.82913929
48GRK10.82100107
49AURKB0.80583177
50PNCK0.78846627
51SIK30.75884417
52MAP3K40.74763200
53ATM0.74213309
54BRD40.73013989
55CSNK1G30.69694802
56BCKDK0.68985918
57NEK20.67471460
58BRSK10.64757113
59ERBB40.64254777
60CHEK10.61028120
61PINK10.58694177
62STK40.58206099
63CCNB10.57135517
64CSNK1G20.56932751
65STK390.56600638
66CSNK1A1L0.53503453
67TLK10.52275349
68OXSR10.48159428
69CSNK2A10.47968608
70CASK0.47064119
71FGFR10.44224958
72RPS6KA40.44079104
73CSNK2A20.43015313
74LATS10.39754435
75DAPK10.39430382
76CDK30.38707347
77DYRK30.38680258
78CLK10.37757415
79AURKA0.37720723
80DYRK20.36637926
81ALK0.36427273
82FLT30.35944102
83CDK70.35641841
84PRKCE0.35147001
85TEC0.34123528
86MAP2K70.33934389
87CDK80.32416330
88CSNK1E0.31542471
89CDK90.31409602
90CDK10.30986116
91CDK20.30538216
92WNK40.30449448
93PRKCI0.29483465
94CDK190.28739746
95PRKDC0.26050191
96RPS6KA50.25746700
97PRKCG0.25356011
98OBSCN0.25071378
99PRKACB0.23019812
100PAK30.23006943

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.23014736
2Mismatch repair_Homo sapiens_hsa034303.37851596
3Non-homologous end-joining_Homo sapiens_hsa034503.30837911
4* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30251516
5DNA replication_Homo sapiens_hsa030303.05688386
6Homologous recombination_Homo sapiens_hsa034403.02308187
7Protein export_Homo sapiens_hsa030603.02112090
8RNA polymerase_Homo sapiens_hsa030202.85232915
9Fanconi anemia pathway_Homo sapiens_hsa034602.53157536
10Base excision repair_Homo sapiens_hsa034102.38192939
11Basal transcription factors_Homo sapiens_hsa030222.35733144
12RNA transport_Homo sapiens_hsa030132.33057793
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32898110
14Oxidative phosphorylation_Homo sapiens_hsa001902.20471064
15RNA degradation_Homo sapiens_hsa030182.16950960
16Nucleotide excision repair_Homo sapiens_hsa034202.13190346
17Spliceosome_Homo sapiens_hsa030402.07420860
18Propanoate metabolism_Homo sapiens_hsa006402.02480997
19Cell cycle_Homo sapiens_hsa041101.93953330
20Parkinsons disease_Homo sapiens_hsa050121.92779972
21One carbon pool by folate_Homo sapiens_hsa006701.84820016
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64820201
23Pyrimidine metabolism_Homo sapiens_hsa002401.64102036
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62808491
25Selenocompound metabolism_Homo sapiens_hsa004501.57094367
26Steroid biosynthesis_Homo sapiens_hsa001001.55168216
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.51562581
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48898189
29Huntingtons disease_Homo sapiens_hsa050161.44032099
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43714532
31Ribosome_Homo sapiens_hsa030101.41058446
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39081425
33Purine metabolism_Homo sapiens_hsa002301.35880701
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34427510
35Pyruvate metabolism_Homo sapiens_hsa006201.33659366
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33652866
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30914044
38Fatty acid elongation_Homo sapiens_hsa000621.25787963
39Alzheimers disease_Homo sapiens_hsa050101.06260995
40Oocyte meiosis_Homo sapiens_hsa041141.04989491
41mRNA surveillance pathway_Homo sapiens_hsa030151.03501689
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03248707
43p53 signaling pathway_Homo sapiens_hsa041151.02952766
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00343451
45Phototransduction_Homo sapiens_hsa047440.88608715
46Glutathione metabolism_Homo sapiens_hsa004800.86953630
47Butanoate metabolism_Homo sapiens_hsa006500.83935412
48Caffeine metabolism_Homo sapiens_hsa002320.82229790
49Sulfur metabolism_Homo sapiens_hsa009200.81851883
50Peroxisome_Homo sapiens_hsa041460.80313986
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79125699
52Carbon metabolism_Homo sapiens_hsa012000.74711023
53Metabolic pathways_Homo sapiens_hsa011000.70124129
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66853426
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64457983
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63171279
57Tryptophan metabolism_Homo sapiens_hsa003800.59602423
58Biosynthesis of amino acids_Homo sapiens_hsa012300.59289268
59Nitrogen metabolism_Homo sapiens_hsa009100.58420357
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57873655
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49377443
62TGF-beta signaling pathway_Homo sapiens_hsa043500.48033084
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.46580175
64Fatty acid metabolism_Homo sapiens_hsa012120.46441392
65Collecting duct acid secretion_Homo sapiens_hsa049660.45989208
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45325372
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43269793
68Regulation of autophagy_Homo sapiens_hsa041400.42964398
69beta-Alanine metabolism_Homo sapiens_hsa004100.41757266
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40263977
71N-Glycan biosynthesis_Homo sapiens_hsa005100.39556433
72Fatty acid degradation_Homo sapiens_hsa000710.38531942
73Folate biosynthesis_Homo sapiens_hsa007900.38431095
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36926392
75Cardiac muscle contraction_Homo sapiens_hsa042600.35584543
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34787763
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.34528443
78Retinol metabolism_Homo sapiens_hsa008300.33278195
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31689756
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30945132
81Epstein-Barr virus infection_Homo sapiens_hsa051690.30335429
82Ether lipid metabolism_Homo sapiens_hsa005650.30278253
83Olfactory transduction_Homo sapiens_hsa047400.28158252
84Linoleic acid metabolism_Homo sapiens_hsa005910.27464850
85Chemical carcinogenesis_Homo sapiens_hsa052040.24950105
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24873776
87Vitamin B6 metabolism_Homo sapiens_hsa007500.23994355
88Primary immunodeficiency_Homo sapiens_hsa053400.23426682
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22212479
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21953044
91Fat digestion and absorption_Homo sapiens_hsa049750.21605345
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21405443
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20948416
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20790132
95Vitamin digestion and absorption_Homo sapiens_hsa049770.19026956
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.18048958
97Legionellosis_Homo sapiens_hsa051340.17817775
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.15844509
99Circadian rhythm_Homo sapiens_hsa047100.15637526
100Wnt signaling pathway_Homo sapiens_hsa043100.14113687

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