RINT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein first identified for its ability to interact with the RAD50 double strand break repair protein, with the resulting interaction implicated in the regulation of cell cycle progression and telomere length. The encoded protein may also play a role in trafficking of cellular cargo from the endosome to the trans-Golgi network. Mutations in this gene may be associated with breast cancer in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.56439023
2nuclear pore organization (GO:0006999)4.48689027
3nucleotide transmembrane transport (GO:1901679)4.32151180
4limb bud formation (GO:0060174)4.16447754
5mitotic sister chromatid segregation (GO:0000070)4.05620533
6mesenchymal cell differentiation involved in renal system development (GO:2001012)4.05417890
7mesenchymal cell differentiation involved in kidney development (GO:0072161)4.05417890
8adenosine metabolic process (GO:0046085)4.01643054
9sister chromatid segregation (GO:0000819)4.00661477
10keratinocyte development (GO:0003334)3.89831842
11mitotic sister chromatid cohesion (GO:0007064)3.84440118
12ribosome assembly (GO:0042255)3.81573045
13mitotic nuclear envelope disassembly (GO:0007077)3.77138365
14proteasome assembly (GO:0043248)3.75443338
15cullin deneddylation (GO:0010388)3.74596958
16protein localization to kinetochore (GO:0034501)3.60043416
17mitotic metaphase plate congression (GO:0007080)3.59732323
18CENP-A containing nucleosome assembly (GO:0034080)3.59429644
19chromatin remodeling at centromere (GO:0031055)3.56816641
20non-recombinational repair (GO:0000726)3.55686575
21double-strand break repair via nonhomologous end joining (GO:0006303)3.55686575
22exocrine pancreas development (GO:0031017)3.55058377
23DNA replication checkpoint (GO:0000076)3.54260086
24tRNA aminoacylation for protein translation (GO:0006418)3.53631257
25pore complex assembly (GO:0046931)3.53377038
26kinetochore organization (GO:0051383)3.49102694
27membrane disassembly (GO:0030397)3.47317880
28nuclear envelope disassembly (GO:0051081)3.47317880
29tRNA aminoacylation (GO:0043039)3.46379707
30amino acid activation (GO:0043038)3.46379707
31endocrine pancreas development (GO:0031018)3.43191922
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42076421
33protein deneddylation (GO:0000338)3.40532933
34DNA double-strand break processing (GO:0000729)3.39947313
35negative regulation of execution phase of apoptosis (GO:1900118)3.39832906
36DNA strand elongation involved in DNA replication (GO:0006271)3.39182498
37ceramide catabolic process (GO:0046514)3.39041890
38preassembly of GPI anchor in ER membrane (GO:0016254)3.37460828
39negative regulation of keratinocyte proliferation (GO:0010839)3.36027575
40metaphase plate congression (GO:0051310)3.35986870
41protein K6-linked ubiquitination (GO:0085020)3.35257580
42formation of translation preinitiation complex (GO:0001731)3.34199188
43mitochondrial RNA metabolic process (GO:0000959)3.33660860
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.33312632
45regulation of mitotic spindle checkpoint (GO:1903504)3.33312632
46GPI anchor biosynthetic process (GO:0006506)3.31247839
47glucosamine-containing compound catabolic process (GO:1901072)3.29713460
48regulation of centriole replication (GO:0046599)3.28293670
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26902446
50DNA strand elongation (GO:0022616)3.26167278
51signal peptide processing (GO:0006465)3.25869849
52synapsis (GO:0007129)3.25072192
53energy homeostasis (GO:0097009)3.22378968
54mannosylation (GO:0097502)3.22200923
55protein localization to chromosome, centromeric region (GO:0071459)3.21143155
56lactate metabolic process (GO:0006089)3.19870500
57kinetochore assembly (GO:0051382)3.18909099
58DNA unwinding involved in DNA replication (GO:0006268)3.18184223
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18088646
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17640759
61superoxide anion generation (GO:0042554)3.17242053
62DNA replication initiation (GO:0006270)3.17027177
63regulation of timing of cell differentiation (GO:0048505)3.15865297
64GPI anchor metabolic process (GO:0006505)3.15737166
65positive regulation of interleukin-8 secretion (GO:2000484)3.14995145
66meiotic chromosome segregation (GO:0045132)3.14174035
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12837681
68androgen biosynthetic process (GO:0006702)3.10050482
69regulation of interleukin-8 secretion (GO:2000482)3.08841134
70replication fork processing (GO:0031297)3.08460744
71mitotic spindle checkpoint (GO:0071174)3.07493563
72histone exchange (GO:0043486)3.07446566
73mitotic recombination (GO:0006312)3.06368077
74spindle checkpoint (GO:0031577)3.05976478
75purine nucleobase biosynthetic process (GO:0009113)3.05362011
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.05324146
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05324146
78telomere maintenance via semi-conservative replication (GO:0032201)3.01621871
79attachment of spindle microtubules to kinetochore (GO:0008608)3.00615088
80DNA catabolic process, exonucleolytic (GO:0000738)2.99264078
81retina layer formation (GO:0010842)2.99077786
82chromosome segregation (GO:0007059)2.96833273
83somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.96140114
84isotype switching (GO:0045190)2.96140114
85somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.96140114
86negative regulation of myoblast differentiation (GO:0045662)2.95876843
87histone H2A acetylation (GO:0043968)2.93753226
88DNA replication-independent nucleosome assembly (GO:0006336)2.93704973
89DNA replication-independent nucleosome organization (GO:0034724)2.93704973
90DNA ligation (GO:0006266)2.93214007
91centriole replication (GO:0007099)2.93185649
92glandular epithelial cell differentiation (GO:0002067)2.92887025
93resolution of meiotic recombination intermediates (GO:0000712)2.92583536
94nucleotide-excision repair, DNA gap filling (GO:0006297)2.91965290
95IMP biosynthetic process (GO:0006188)2.91901220
96DNA replication-dependent nucleosome organization (GO:0034723)2.91817712
97DNA replication-dependent nucleosome assembly (GO:0006335)2.91817712
98mesenchymal cell differentiation (GO:0048762)2.90762816
99spinal cord association neuron differentiation (GO:0021527)2.90206632
100establishment of integrated proviral latency (GO:0075713)2.89590146
101RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89147045
102rRNA modification (GO:0000154)2.88897733
103lymphoid progenitor cell differentiation (GO:0002320)2.87594457
104telomere maintenance via recombination (GO:0000722)2.87208242
105nucleobase biosynthetic process (GO:0046112)2.85962362
106response to X-ray (GO:0010165)2.85221856
107presynaptic membrane assembly (GO:0097105)2.84241475
108rRNA methylation (GO:0031167)2.84082104
109pharyngeal system development (GO:0060037)2.83526263
110positive regulation of chromosome segregation (GO:0051984)2.82978969
111DNA integration (GO:0015074)2.82872679
112negative regulation of chromosome segregation (GO:0051985)2.82668657
113cornea development in camera-type eye (GO:0061303)2.82627345
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82009002
115cell differentiation in spinal cord (GO:0021515)2.81209100
116histone H2B ubiquitination (GO:0033523)2.81086438
117developmental pigmentation (GO:0048066)2.80999918
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80955960
119negative regulation of ligase activity (GO:0051352)2.80955960
120sphingoid metabolic process (GO:0046519)2.80054652
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.79176003
122negative regulation of sister chromatid segregation (GO:0033046)2.79176003
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79176003
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79176003
125negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79176003
126intra-S DNA damage checkpoint (GO:0031573)2.78606967
127UDP-N-acetylglucosamine metabolic process (GO:0006047)2.78536274
128spliceosomal snRNP assembly (GO:0000387)2.77199023
129signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76059977
130signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76059977
131signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76059977
1327-methylguanosine mRNA capping (GO:0006370)2.75714267
133mitotic spindle assembly checkpoint (GO:0007094)2.75047042
134nuclear envelope organization (GO:0006998)2.73826780
135nucleoside diphosphate catabolic process (GO:0009134)2.73593835
136glycolipid catabolic process (GO:0019377)2.73465492
137positive regulation of cellular amine metabolic process (GO:0033240)2.73383463
138positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73374646
139positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73374646
140positive regulation of mitotic sister chromatid separation (GO:1901970)2.73374646
141regulation of pigment cell differentiation (GO:0050932)2.73313063
142C-terminal protein lipidation (GO:0006501)2.72330618
143regulation of development, heterochronic (GO:0040034)2.69865286
144nucleotide transport (GO:0006862)2.69757639
145ER overload response (GO:0006983)2.67793074
146spinal cord motor neuron differentiation (GO:0021522)2.67704108
147positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.67051229
148tRNA methylation (GO:0030488)2.66304315
149negative regulation of DNA-dependent DNA replication (GO:2000104)2.66213103
150cell differentiation involved in metanephros development (GO:0072202)2.65073306
151tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64524962
152RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64524962
153polyol transport (GO:0015791)2.64497679
154photoreceptor cell maintenance (GO:0045494)2.63398616
155transcription elongation from RNA polymerase I promoter (GO:0006362)2.62717895
156amino sugar catabolic process (GO:0046348)2.62513337
157activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.62043792
158negative regulation of transcription by competitive promoter binding (GO:0010944)2.61614605
159detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61286925
160response to redox state (GO:0051775)2.59306490
161protein heterotetramerization (GO:0051290)2.59168894
162intraciliary transport (GO:0042073)2.58773660
163regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58737256
164mesonephros development (GO:0001823)2.58580366
165female gonad development (GO:0008585)2.57799668
166hepatocyte differentiation (GO:0070365)2.56829721
167regulation of DNA endoreduplication (GO:0032875)2.56451751
168termination of RNA polymerase I transcription (GO:0006363)2.55403749
169cell proliferation in forebrain (GO:0021846)2.55116089
170sympathetic nervous system development (GO:0048485)2.55099166
171male sex determination (GO:0030238)2.54600715
172response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.53167901
173histone H3-K4 trimethylation (GO:0080182)2.53022328
174somite development (GO:0061053)2.52673495
175long-chain fatty acid biosynthetic process (GO:0042759)2.52326645
176presynaptic membrane organization (GO:0097090)2.51681556
177positive regulation of uterine smooth muscle contraction (GO:0070474)2.51186367
178DNA strand renaturation (GO:0000733)2.48723440
179G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.48240826
180regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46873196
181C-terminal protein amino acid modification (GO:0018410)2.46557565
182diol metabolic process (GO:0034311)2.45891128
183nonmotile primary cilium assembly (GO:0035058)2.44759426
184histone H3-K36 demethylation (GO:0070544)2.42294840
185sphingolipid catabolic process (GO:0030149)2.40923010
186deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.40667766
187kidney morphogenesis (GO:0060993)2.40039405
188positive regulation of protein kinase C signaling (GO:0090037)2.39777024
189positive regulation of cell fate commitment (GO:0010455)2.39123508
190lens development in camera-type eye (GO:0002088)2.38664347
191detection of other organism (GO:0098543)2.36845967
192oligosaccharide catabolic process (GO:0009313)2.36516902
193detection of bacterium (GO:0016045)2.36463281
194omega-hydroxylase P450 pathway (GO:0097267)2.36355236
195natural killer cell activation involved in immune response (GO:0002323)2.36254944
196glycosphingolipid catabolic process (GO:0046479)2.36006103
197membrane lipid catabolic process (GO:0046466)2.35905056
198regulation of phospholipase A2 activity (GO:0032429)2.35369337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.03897113
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.78925297
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70140751
4GBX2_23144817_ChIP-Seq_PC3_Human3.40256582
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.22834086
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01563640
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.88340104
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87394342
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.87023062
10ELK1_19687146_ChIP-ChIP_HELA_Human2.86538888
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.79666077
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.78742034
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.73321618
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.72928603
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.67110554
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61305934
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.58731404
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57027438
19* VDR_23849224_ChIP-Seq_CD4+_Human2.53261788
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50571703
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50200032
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.49391170
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.48538885
24SUZ12_27294783_Chip-Seq_NPCs_Mouse2.46535210
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44502980
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40116926
27* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.33895571
28NFE2_27457419_Chip-Seq_LIVER_Mouse2.32623154
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30352183
30IGF1R_20145208_ChIP-Seq_DFB_Human2.22235130
31EZH2_27294783_Chip-Seq_NPCs_Mouse2.19755681
32MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16635365
33IRF1_19129219_ChIP-ChIP_H3396_Human2.14860707
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14740564
35PADI4_21655091_ChIP-ChIP_MCF-7_Human2.14308457
36FOXP3_21729870_ChIP-Seq_TREG_Human2.10097858
37* DCP1A_22483619_ChIP-Seq_HELA_Human2.09636030
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08449995
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.06766340
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03498088
41SUZ12_18555785_Chip-Seq_ESCs_Mouse2.02631512
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02483621
43NANOG_18555785_Chip-Seq_ESCs_Mouse2.01650593
44GABP_19822575_ChIP-Seq_HepG2_Human1.99549458
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.99496604
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99448585
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96716160
48P53_22387025_ChIP-Seq_ESCs_Mouse1.95416049
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.95263776
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.94611913
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.93613206
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91938919
53AR_21909140_ChIP-Seq_LNCAP_Human1.91342617
54NMYC_18555785_Chip-Seq_ESCs_Mouse1.88860221
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88739981
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88180947
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86229016
58EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.86094822
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.82903747
60TAF15_26573619_Chip-Seq_HEK293_Human1.82605838
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.82359929
62* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81482725
63P300_18555785_Chip-Seq_ESCs_Mouse1.81010032
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.77092689
65RUNX1_27457419_Chip-Seq_LIVER_Mouse1.75431409
66P300_19829295_ChIP-Seq_ESCs_Human1.73738919
67VDR_22108803_ChIP-Seq_LS180_Human1.73662431
68OCT4_18555785_Chip-Seq_ESCs_Mouse1.69698759
69TTF2_22483619_ChIP-Seq_HELA_Human1.69245053
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68979045
71ZFX_18555785_Chip-Seq_ESCs_Mouse1.67177121
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.66856488
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.66792979
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66221580
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64643043
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63979894
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.63921354
78KLF4_18555785_Chip-Seq_ESCs_Mouse1.62902239
79PU1_27457419_Chip-Seq_LIVER_Mouse1.62094113
80EZH2_22144423_ChIP-Seq_EOC_Human1.61814654
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.60557128
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.60034155
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59658415
84SMAD1_18555785_Chip-Seq_ESCs_Mouse1.58486825
85FUS_26573619_Chip-Seq_HEK293_Human1.58357361
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57814836
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56782831
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.56181959
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.55440439
90MYC_18940864_ChIP-ChIP_HL60_Human1.55105075
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54330620
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53515961
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52522972
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52284226
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52077026
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51641137
97KDM5A_27292631_Chip-Seq_BREAST_Human1.51343779
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.51033833
99XRN2_22483619_ChIP-Seq_HELA_Human1.49876170
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49810145
101ZNF274_21170338_ChIP-Seq_K562_Hela1.48780939
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48576360
103EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48324748
104CTCF_18555785_Chip-Seq_ESCs_Mouse1.48129912
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.47054495
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.44486649
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43007472
108RNF2_27304074_Chip-Seq_NSC_Mouse1.41432428
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40144946
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37726729
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37385165
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.36336034
113* ER_23166858_ChIP-Seq_MCF-7_Human1.34308888
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33122995
115EWS_26573619_Chip-Seq_HEK293_Human1.32768695
116HTT_18923047_ChIP-ChIP_STHdh_Human1.32185181
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30835078
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30244208
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29369508
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29369508
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28729637
122SMAD_19615063_ChIP-ChIP_OVARY_Human1.28647980
123ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28599278
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27530478
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26618746
126SMAD4_21799915_ChIP-Seq_A2780_Human1.26330395
127MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25984535
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.24637462
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22842184
130JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21118517
131NOTCH1_21737748_ChIP-Seq_TLL_Human1.20154024
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17739662
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17586821
134TCF4_23295773_ChIP-Seq_U87_Human1.17513522
135STAT3_23295773_ChIP-Seq_U87_Human1.16936880
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15532607
137TP53_18474530_ChIP-ChIP_U2OS_Human1.15232246
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14197221
139RUNX2_22187159_ChIP-Seq_PCA_Human1.13913791
140TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12125310
141MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09952315
142ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09737803
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09491647
144KDM2B_26808549_Chip-Seq_REH_Human1.09262610
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07837367
146* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07832598
147CIITA_25753668_ChIP-Seq_RAJI_Human1.06859414
148AR_21572438_ChIP-Seq_LNCaP_Human1.05848739
149CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05179512
150SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03901999
151NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01922252
152NFYB_21822215_ChIP-Seq_K562_Human1.01717674
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01526437
154PHF8_20622853_ChIP-Seq_HELA_Human1.01518467
155YY1_21170310_ChIP-Seq_MESCs_Mouse1.00636412
156TFEB_21752829_ChIP-Seq_HELA_Human0.99672837
157LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97980041
158PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97509733
159EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96476183
160CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91870947
161HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90224044
162CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84972040
163* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84361666
164NANOG_16153702_ChIP-ChIP_HESCs_Human0.83699490
165NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82270343
166POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80848648
167SOX17_20123909_ChIP-Seq_XEN_Mouse0.80736596
168ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79536078
169* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79002690
170ELK1_22589737_ChIP-Seq_MCF10A_Human0.78438053
171DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78067475
172BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.76033994
173CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74806996
174FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.73823053
175CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.69852117
176EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.69184547
177* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69015029
178ELF5_23300383_ChIP-Seq_T47D_Human0.66912970
179CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.65290133
180TP53_22573176_ChIP-Seq_HFKS_Human0.65270488
181CBP_20019798_ChIP-Seq_JUKART_Human0.65045614
182IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.65045614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.66422035
2MP0003693_abnormal_embryo_hatching3.83726510
3MP0001188_hyperpigmentation3.68762866
4MP0000566_synostosis3.63607582
5MP0006292_abnormal_olfactory_placode3.57859180
6MP0003136_yellow_coat_color3.55876639
7MP0004957_abnormal_blastocyst_morpholog3.35781394
8MP0003111_abnormal_nucleus_morphology3.27663695
9MP0004381_abnormal_hair_follicle3.11788815
10MP0002102_abnormal_ear_morphology2.82657748
11MP0003077_abnormal_cell_cycle2.80976292
12MP0005409_darkened_coat_color2.67015755
13MP0001986_abnormal_taste_sensitivity2.66105379
14MP0005379_endocrine/exocrine_gland_phen2.66104109
15MP0008877_abnormal_DNA_methylation2.59965620
16MP0008007_abnormal_cellular_replicative2.58461747
17MP0002277_abnormal_respiratory_mucosa2.56580824
18MP0010386_abnormal_urinary_bladder2.40422985
19MP0003718_maternal_effect2.34323850
20MP0008932_abnormal_embryonic_tissue2.16309546
21MP0003195_calcinosis2.14362283
22MP0009379_abnormal_foot_pigmentation2.12407924
23MP0005408_hypopigmentation2.11821562
24MP0005220_abnormal_exocrine_pancreas2.04261430
25MP0003868_abnormal_feces_composition2.03822216
26MP0009697_abnormal_copulation1.99813275
27MP0003941_abnormal_skin_development1.98036826
28MP0005451_abnormal_body_composition1.96302695
29MP0008058_abnormal_DNA_repair1.96291407
30MP0005171_absent_coat_pigmentation1.93502215
31MP0005646_abnormal_pituitary_gland1.88140122
32MP0002938_white_spotting1.84042179
33MP0002876_abnormal_thyroid_physiology1.82052953
34MP0002693_abnormal_pancreas_physiology1.77264299
35MP0002638_abnormal_pupillary_reflex1.72772533
36MP0003787_abnormal_imprinting1.65339261
37MP0003646_muscle_fatigue1.65125548
38MP0005174_abnormal_tail_pigmentation1.65118537
39MP0000015_abnormal_ear_pigmentation1.61726209
40MP0006072_abnormal_retinal_apoptosis1.61449442
41MP0000383_abnormal_hair_follicle1.60576745
42MP0000613_abnormal_salivary_gland1.55397099
43MP0003186_abnormal_redox_activity1.54816492
44MP0001730_embryonic_growth_arrest1.54296100
45MP0002837_dystrophic_cardiac_calcinosis1.53684787
46MP0002095_abnormal_skin_pigmentation1.50027975
47MP0004742_abnormal_vestibular_system1.49501946
48MP0000371_diluted_coat_color1.45215484
49MP0000026_abnormal_inner_ear1.39043678
50MP0001697_abnormal_embryo_size1.35145285
51MP0001944_abnormal_pancreas_morphology1.33907193
52MP0006036_abnormal_mitochondrial_physio1.33669821
53MP0001929_abnormal_gametogenesis1.32839572
54MP0005084_abnormal_gallbladder_morpholo1.30515895
55MP0002009_preneoplasia1.30492542
56MP0000350_abnormal_cell_proliferation1.30471432
57MP0004233_abnormal_muscle_weight1.29613613
58MP0004142_abnormal_muscle_tone1.27698325
59MP0002138_abnormal_hepatobiliary_system1.27089441
60MP0002160_abnormal_reproductive_system1.26074203
61MP0005075_abnormal_melanosome_morpholog1.25938746
62MP0002098_abnormal_vibrissa_morphology1.20357732
63MP0008789_abnormal_olfactory_epithelium1.19504263
64MP0000678_abnormal_parathyroid_gland1.19124626
65MP0005551_abnormal_eye_electrophysiolog1.18926521
66MP0000462_abnormal_digestive_system1.18788446
67MP0005365_abnormal_bile_salt1.18129172
68MP0010352_gastrointestinal_tract_polyps1.17238785
69MP0008004_abnormal_stomach_pH1.17201673
70MP0003724_increased_susceptibility_to1.17009324
71MP0003950_abnormal_plasma_membrane1.15938796
72MP0006035_abnormal_mitochondrial_morpho1.15306675
73MP0005503_abnormal_tendon_morphology1.15294321
74MP0002132_abnormal_respiratory_system1.14830093
75MP0002163_abnormal_gland_morphology1.14757173
76MP0002210_abnormal_sex_determination1.14255051
77MP0000372_irregular_coat_pigmentation1.13747800
78MP0001666_abnormal_nutrient_absorption1.13517903
79MP0000631_abnormal_neuroendocrine_gland1.12338139
80* MP0002080_prenatal_lethality1.12003807
81MP0003937_abnormal_limbs/digits/tail_de1.10943766
82* MP0005380_embryogenesis_phenotype1.10744245
83* MP0001672_abnormal_embryogenesis/_devel1.10744245
84MP0008995_early_reproductive_senescence1.10687043
85MP0002177_abnormal_outer_ear1.10061735
86MP0001984_abnormal_olfaction1.07355111
87MP0002084_abnormal_developmental_patter1.05075084
88MP0003221_abnormal_cardiomyocyte_apopto1.04524710
89MP0010234_abnormal_vibrissa_follicle1.03569590
90MP0000313_abnormal_cell_death1.03493937
91MP0001485_abnormal_pinna_reflex1.02238878
92MP0004782_abnormal_surfactant_physiolog1.02117567
93MP0005645_abnormal_hypothalamus_physiol1.01915669
94MP0001661_extended_life_span1.01781241
95MP0001963_abnormal_hearing_physiology1.00421180
96MP0005395_other_phenotype1.00246911
97MP0001664_abnormal_digestion0.99525635
98MP0000049_abnormal_middle_ear0.99094753
99MP0005253_abnormal_eye_physiology0.99057619
100MP0003984_embryonic_growth_retardation0.98897612
101MP0002088_abnormal_embryonic_growth/wei0.97183677
102MP0002090_abnormal_vision0.96240874
103MP0010307_abnormal_tumor_latency0.96112909
104MP0003656_abnormal_erythrocyte_physiolo0.95686377
105MP0003786_premature_aging0.95672308
106MP0004043_abnormal_pH_regulation0.95306536
107MP0000427_abnormal_hair_cycle0.95202600
108MP0003938_abnormal_ear_development0.95136631
109MP0004197_abnormal_fetal_growth/weight/0.95132620
110MP0001186_pigmentation_phenotype0.95075031
111MP0003890_abnormal_embryonic-extraembry0.94487775
112MP0000470_abnormal_stomach_morphology0.94058679
113MP0000653_abnormal_sex_gland0.93630968
114MP0003183_abnormal_peptide_metabolism0.93344422
115MP0000749_muscle_degeneration0.92802223
116MP0000579_abnormal_nail_morphology0.92730591
117MP0005083_abnormal_biliary_tract0.92549057
118MP0004134_abnormal_chest_morphology0.92157506
119MP0001145_abnormal_male_reproductive0.91989822
120MP0008057_abnormal_DNA_replication0.91443150
121MP0002085_abnormal_embryonic_tissue0.91440832
122MP0002269_muscular_atrophy0.90332295
123MP0000762_abnormal_tongue_morphology0.89818827
124MP0000358_abnormal_cell_content/0.89258529
125MP0004215_abnormal_myocardial_fiber0.89215329
126MP0000681_abnormal_thyroid_gland0.89101670
127MP0005389_reproductive_system_phenotype0.87937688
128MP0001529_abnormal_vocalization0.87133859
129MP0001346_abnormal_lacrimal_gland0.87125082
130MP0001293_anophthalmia0.86857686
131MP0003698_abnormal_male_reproductive0.85330135
132MP0006276_abnormal_autonomic_nervous0.84580053
133MP0003121_genomic_imprinting0.83858166
134MP0000647_abnormal_sebaceous_gland0.83700196
135MP0001286_abnormal_eye_development0.81859310
136MP0009250_abnormal_appendicular_skeleto0.80300885
137MP0002075_abnormal_coat/hair_pigmentati0.79796510
138MP0009703_decreased_birth_body0.79787519
139MP0009764_decreased_sensitivity_to0.79264092
140MP0002928_abnormal_bile_duct0.78792553
141MP0002396_abnormal_hematopoietic_system0.78498705
142MP0002086_abnormal_extraembryonic_tissu0.78236310
143MP0001324_abnormal_eye_pigmentation0.77134627
144MP0010678_abnormal_skin_adnexa0.75832626
145MP0002751_abnormal_autonomic_nervous0.74058233
146MP0001486_abnormal_startle_reflex0.74003898
147MP0003943_abnormal_hepatobiliary_system0.73617630
148MP0000538_abnormal_urinary_bladder0.73513535
149MP0008260_abnormal_autophagy0.73383244
150MP0001270_distended_abdomen0.71900584
151MP0004808_abnormal_hematopoietic_stem0.71564810
152MP0001119_abnormal_female_reproductive0.70991142
153MP0002249_abnormal_larynx_morphology0.70231214
154MP0005085_abnormal_gallbladder_physiolo0.67082469
155MP0005394_taste/olfaction_phenotype0.66086453
156MP0005499_abnormal_olfactory_system0.66086453
157MP0005384_cellular_phenotype0.65674148
158MP0005187_abnormal_penis_morphology0.65153256
159MP0002109_abnormal_limb_morphology0.65144447
160MP0005266_abnormal_metabolism0.64922295
161MP0002877_abnormal_melanocyte_morpholog0.64070345
162MP0004147_increased_porphyrin_level0.63732270
163MP0005257_abnormal_intraocular_pressure0.62909388
164MP0004019_abnormal_vitamin_homeostasis0.62744341
165MP0000163_abnormal_cartilage_morphology0.61955605
166MP0003011_delayed_dark_adaptation0.61213593
167MP0001764_abnormal_homeostasis0.60081814

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.62399146
2Chromsome breakage (HP:0040012)4.02413843
3Renal cortical cysts (HP:0000803)3.66429110
4Volvulus (HP:0002580)3.55774935
5Duplicated collecting system (HP:0000081)3.51928151
6Abnormality of glycolysis (HP:0004366)3.38257347
7Osteomalacia (HP:0002749)3.25560157
8Abnormality of DNA repair (HP:0003254)3.25177038
9Abnormality of the renal collecting system (HP:0004742)3.16883746
10Increased serum pyruvate (HP:0003542)3.15888043
11Hypothermia (HP:0002045)3.06218499
12Upper limb muscle weakness (HP:0003484)2.99947706
13Birth length less than 3rd percentile (HP:0003561)2.99027209
14Abnormality of incisor morphology (HP:0011063)2.96985463
15Conjugated hyperbilirubinemia (HP:0002908)2.93630676
16Acute necrotizing encephalopathy (HP:0006965)2.91794179
17Congenital sensorineural hearing impairment (HP:0008527)2.89890002
18Parakeratosis (HP:0001036)2.85775562
19Acute encephalopathy (HP:0006846)2.81669694
20Progressive macrocephaly (HP:0004481)2.79372292
21Septo-optic dysplasia (HP:0100842)2.75011791
22Tubulointerstitial nephritis (HP:0001970)2.71247603
23Ependymoma (HP:0002888)2.69001431
24White forelock (HP:0002211)2.67664268
25Increased CSF lactate (HP:0002490)2.67556233
26Patchy hypopigmentation of hair (HP:0011365)2.66269355
27Abnormal mitochondria in muscle tissue (HP:0008316)2.64388311
28Type I transferrin isoform profile (HP:0003642)2.59316609
29Symptomatic seizures (HP:0011145)2.56190552
30Optic nerve hypoplasia (HP:0000609)2.45148639
31Mitochondrial inheritance (HP:0001427)2.44598329
32Hypoglycemic seizures (HP:0002173)2.43881937
33Congenital primary aphakia (HP:0007707)2.43708494
34Medial flaring of the eyebrow (HP:0010747)2.43139435
35Prolonged partial thromboplastin time (HP:0003645)2.42955235
36Small intestinal stenosis (HP:0012848)2.42466104
37Duodenal stenosis (HP:0100867)2.42466104
38Increased serum lactate (HP:0002151)2.39750299
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.38775286
40Hypoplasia of the fovea (HP:0007750)2.38660326
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.38660326
42Absent/shortened dynein arms (HP:0200106)2.38508677
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.38508677
44Abnormality of the renal cortex (HP:0011035)2.38100582
45Sloping forehead (HP:0000340)2.38093664
46Hepatocellular necrosis (HP:0001404)2.37475037
47Cerebral edema (HP:0002181)2.35806475
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.32998009
49Hyperinsulinemic hypoglycemia (HP:0000825)2.32882975
50Cutaneous melanoma (HP:0012056)2.31574576
51Gait imbalance (HP:0002141)2.27461021
52Chronic hepatic failure (HP:0100626)2.26224354
53Nephrogenic diabetes insipidus (HP:0009806)2.25902815
54Joint hemorrhage (HP:0005261)2.25674167
55Abnormality of the axillary hair (HP:0100134)2.25322470
56Abnormality of secondary sexual hair (HP:0009888)2.25322470
57Glioma (HP:0009733)2.22802871
58Submucous cleft hard palate (HP:0000176)2.22235918
59True hermaphroditism (HP:0010459)2.20112002
60Abnormality of methionine metabolism (HP:0010901)2.19807830
61Colon cancer (HP:0003003)2.19119456
62Abnormality of the preputium (HP:0100587)2.17485760
63Astrocytoma (HP:0009592)2.15890292
64Abnormality of the astrocytes (HP:0100707)2.15890292
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15594923
66Lactic acidosis (HP:0003128)2.13004622
67Decreased central vision (HP:0007663)2.12769121
68Enlarged kidneys (HP:0000105)2.12767558
69Reticulocytopenia (HP:0001896)2.12165716
70Abnormal gallbladder physiology (HP:0012438)2.11722317
71Cholecystitis (HP:0001082)2.11722317
72Myelodysplasia (HP:0002863)2.11450652
73Microvesicular hepatic steatosis (HP:0001414)2.09504704
74Abnormal ciliary motility (HP:0012262)2.08957107
75Methylmalonic acidemia (HP:0002912)2.06471882
76Abnormality of the labia minora (HP:0012880)2.05755705
77Increased hepatocellular lipid droplets (HP:0006565)2.04627440
78Hepatic necrosis (HP:0002605)2.03635048
79Abnormality of the duodenum (HP:0002246)2.02845378
80Ectopic kidney (HP:0000086)2.02375648
81Aplasia/Hypoplasia of the tibia (HP:0005772)2.01337509
82Abnormality of midbrain morphology (HP:0002418)1.99739534
83Molar tooth sign on MRI (HP:0002419)1.99739534
84Abnormal hair whorl (HP:0010721)1.99379531
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.98792966
86Meckel diverticulum (HP:0002245)1.96889402
87Congenital stationary night blindness (HP:0007642)1.96628258
88Aplasia cutis congenita (HP:0001057)1.95923080
89Duplication of thumb phalanx (HP:0009942)1.95847160
90Retinal dysplasia (HP:0007973)1.95185467
91Lipid accumulation in hepatocytes (HP:0006561)1.94378848
92Metaphyseal irregularity (HP:0003025)1.93826886
93Clubbing of toes (HP:0100760)1.93777372
94Abnormal protein glycosylation (HP:0012346)1.92780529
95Abnormal glycosylation (HP:0012345)1.92780529
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92780529
97Abnormal protein N-linked glycosylation (HP:0012347)1.92780529
98Lip pit (HP:0100267)1.92464904
99Astigmatism (HP:0000483)1.92153927
100Reduced antithrombin III activity (HP:0001976)1.91626279
101Decreased circulating renin level (HP:0003351)1.91158842
102Conical tooth (HP:0000698)1.90932707
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90878900
104Adenoma sebaceum (HP:0009720)1.89892446
105Angiofibromas (HP:0010615)1.89892446
106Abnormality of chromosome stability (HP:0003220)1.88423673
107Degeneration of anterior horn cells (HP:0002398)1.86339300
108Abnormality of the anterior horn cell (HP:0006802)1.86339300
109Type II lissencephaly (HP:0007260)1.86104000
110Short tibia (HP:0005736)1.85710825
111Anhidrosis (HP:0000970)1.85609395
112Abnormal lung lobation (HP:0002101)1.85435864
113Abnormality of the renal medulla (HP:0100957)1.85176199
114Postnatal microcephaly (HP:0005484)1.83279168
115Oligohydramnios (HP:0001562)1.82168717
116Intestinal atresia (HP:0011100)1.82077333
117Progressive inability to walk (HP:0002505)1.81434633
118Hypophosphatemic rickets (HP:0004912)1.80689591
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80630307
120Poor coordination (HP:0002370)1.80357360
121Attenuation of retinal blood vessels (HP:0007843)1.79849223
1223-Methylglutaconic aciduria (HP:0003535)1.79821591
123Abnormality of the ileum (HP:0001549)1.79724180
124Nephronophthisis (HP:0000090)1.77511936
125Ectropion (HP:0000656)1.76685893
126Abnormality of the carotid arteries (HP:0005344)1.76677819
127Median cleft lip (HP:0000161)1.76584677
128Abnormality of the fovea (HP:0000493)1.76541132
129Protruding tongue (HP:0010808)1.75550280
130Overlapping toe (HP:0001845)1.74892072
131Abnormal respiratory epithelium morphology (HP:0012253)1.74633328
132Abnormal respiratory motile cilium morphology (HP:0005938)1.74633328
133Oculomotor apraxia (HP:0000657)1.74325223
134Neoplasm of the colon (HP:0100273)1.74251665
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.73043221
136Thyroid-stimulating hormone excess (HP:0002925)1.72367702
137Acute myeloid leukemia (HP:0004808)1.71990468
138Pancreatic fibrosis (HP:0100732)1.71960873
139Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71243892
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70530065
141Abnormality of alanine metabolism (HP:0010916)1.70530065
142Hyperalaninemia (HP:0003348)1.70530065
143Poor head control (HP:0002421)1.70472155
144Anomalous pulmonary venous return (HP:0010772)1.70296391
145Fair hair (HP:0002286)1.69784654
146Breast carcinoma (HP:0003002)1.69708491
147Dry hair (HP:0011359)1.68991375
148Generalized hypopigmentation of hair (HP:0011358)1.68596170
149Cafe-au-lait spot (HP:0000957)1.68454695
150Abnormality of calcium-phosphate metabolism (HP:0100530)1.68408246
151Aplasia/hypoplasia of the uterus (HP:0008684)1.68186044
152Furrowed tongue (HP:0000221)1.68156829
153Neoplasm of the adrenal gland (HP:0100631)1.68001527
154Exercise intolerance (HP:0003546)1.67378509
155Fibular hypoplasia (HP:0003038)1.67303507
156Abnormality of the columella (HP:0009929)1.67074274
157Aganglionic megacolon (HP:0002251)1.66742857
158Abnormality of the incisor (HP:0000676)1.66270290
159Genital tract atresia (HP:0001827)1.65762093
160Febrile seizures (HP:0002373)1.65424444
161Entropion (HP:0000621)1.64005428
162Pancreatic cysts (HP:0001737)1.63963811
163Renal agenesis (HP:0000104)1.63801983
164Male pseudohermaphroditism (HP:0000037)1.63286221
165Homocystinuria (HP:0002156)1.63259300
166Abnormality of homocysteine metabolism (HP:0010919)1.63259300
167Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63115328
168Vaginal atresia (HP:0000148)1.62518349
169Prominent nasal bridge (HP:0000426)1.62516619
170Exercise-induced muscle cramps (HP:0003710)1.62119894
171Atelectasis (HP:0100750)1.61811016
172Severe visual impairment (HP:0001141)1.61097911
173Absent septum pellucidum (HP:0001331)1.60539110
174Hypoplastic pelvis (HP:0008839)1.60483483
175Hyperglycinemia (HP:0002154)1.60376547
176Medulloblastoma (HP:0002885)1.59253824
177Respiratory failure (HP:0002878)1.59199414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.01568095
2INSRR3.78338090
3IRAK33.40596297
4STK163.24977692
5NEK13.24501240
6BUB13.19274186
7TSSK63.02046965
8EIF2AK12.83303786
9TRIM282.82172409
10TTK2.77473647
11IRAK42.68970041
12TNIK2.63288322
13ACVR1B2.58671092
14MKNK22.56739303
15WEE12.50053444
16BRSK22.41262756
17BMPR1B2.33964349
18ZAK2.29584617
19PDK22.25015519
20PLK32.24483536
21IRAK22.04410195
22NEK62.03500109
23CDC71.98532690
24NUAK11.97734948
25EIF2AK21.82868898
26MKNK11.81078577
27IRAK11.79806145
28SRPK11.76743740
29TAOK31.74046693
30AKT31.68190388
31CCNB11.67633989
32BLK1.64038327
33NME11.60132576
34TXK1.59547083
35GRK11.56074067
36MAP2K71.55988424
37MAP3K141.45634875
38MAPK151.42839163
39PLK11.42598986
40PKN11.40531217
41EPHA31.35244247
42PIK3CA1.34883967
43PLK21.33957364
44PIK3CG1.31640719
45TNK21.31038132
46SCYL21.29160661
47ADRBK21.28845974
48CDK31.23750446
49YES11.22543922
50PNCK1.11771731
51BRD41.08596222
52PASK1.06878279
53AURKB1.06393306
54BMPR21.00608679
55TEC1.00495491
56BRSK11.00324237
57WNK30.99656131
58PBK0.99245229
59STK240.95424238
60CHEK10.93666389
61VRK20.92831452
62NLK0.92758634
63MAP4K20.92328434
64PRPF4B0.88705919
65MUSK0.88693535
66GRK70.86384826
67SIK30.84596243
68TLK10.83723660
69VRK10.83378816
70KSR10.82638350
71SGK20.82464343
72CLK10.82406115
73STK390.81940047
74MARK30.79622963
75ERBB40.78969140
76NEK20.77362147
77CSNK1G30.76812368
78BCR0.76213800
79STK38L0.76135463
80EIF2AK30.73928185
81RPS6KA40.73033998
82MAPK130.72629182
83PRKCE0.68701697
84MST1R0.68131034
85MAP3K20.67273375
86DYRK20.67198860
87IKBKB0.66083052
88MET0.64188059
89PLK40.63309291
90IKBKE0.62191020
91PRKCI0.61932578
92RPS6KA50.60995529
93MAP3K40.60934958
94WNK10.60139454
95FRK0.60112957
96CDK80.59408935
97HIPK20.58844371
98FLT30.57915321
99CDK10.57813163
100SGK2230.56624671
101SGK4940.56624671
102MST40.55823356
103CDK70.55606528
104CDK190.55236197
105CSNK1G20.53896101
106STK30.53436016
107LYN0.53285602
108TIE10.53131753
109STK40.51744138
110BRAF0.51554877
111ADRBK10.51229203
112BTK0.50513943
113OXSR10.50508817
114CSNK2A20.50167020
115CDC42BPA0.49330089
116LATS10.48592719
117CDK20.46503737
118AURKA0.45805533
119DYRK30.45790524
120TRPM70.45593499
121RAF10.44880826
122STK100.44130052
123CSNK1A1L0.43442390
124CDK90.42504914
125MINK10.41681782
126OBSCN0.41088951
127PINK10.39845361
128ATR0.39104715
129TAF10.38426874
130MARK20.37029083
131CDK60.36637387
132MAPKAPK30.36619089
133MAPKAPK50.36449522
134PRKG10.36008832
135CSNK1E0.35805692
136AKT20.35527125
137PRKAA20.34860887
138ERBB30.33765020
139PHKG10.33304409
140PHKG20.33304409
141RPS6KB20.32353114
142BCKDK0.31772693
143CAMKK20.31767988
144CHEK20.30965424
145JAK30.30851613
146MAPK70.30667851
147PRKDC0.30497766
148PRKACA0.30402222
149ATM0.30319211
150PRKCQ0.29559861
151WNK40.28905345
152LCK0.27001261
153CAMK10.26942956
154CAMK2D0.26586001
155RPS6KB10.26314598
156CSNK1G10.26144288
157NME20.25471809
158CHUK0.25236819
159CSNK2A10.25151803

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.43636596
2Protein export_Homo sapiens_hsa030604.31977624
3Proteasome_Homo sapiens_hsa030503.42723490
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.88489685
5RNA transport_Homo sapiens_hsa030132.67058323
6Fanconi anemia pathway_Homo sapiens_hsa034602.59904329
7Fatty acid elongation_Homo sapiens_hsa000622.22824603
8Spliceosome_Homo sapiens_hsa030402.10612675
9Propanoate metabolism_Homo sapiens_hsa006402.06552457
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04573487
11Homologous recombination_Homo sapiens_hsa034402.00223324
12Sphingolipid metabolism_Homo sapiens_hsa006001.95060244
13Cell cycle_Homo sapiens_hsa041101.94875617
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94801737
15Non-homologous end-joining_Homo sapiens_hsa034501.87429964
16Selenocompound metabolism_Homo sapiens_hsa004501.74431261
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72031519
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70880233
19Arachidonic acid metabolism_Homo sapiens_hsa005901.70710877
20Linoleic acid metabolism_Homo sapiens_hsa005911.68219084
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.66036474
22Basal transcription factors_Homo sapiens_hsa030221.64638222
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61004503
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59900124
25Nucleotide excision repair_Homo sapiens_hsa034201.58072687
26Pyruvate metabolism_Homo sapiens_hsa006201.54977606
27Phototransduction_Homo sapiens_hsa047441.54945102
28Other glycan degradation_Homo sapiens_hsa005111.51955364
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48597586
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.47593829
31Ether lipid metabolism_Homo sapiens_hsa005651.47394515
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46596229
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46000291
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45211205
35Steroid biosynthesis_Homo sapiens_hsa001001.42381802
36Sulfur metabolism_Homo sapiens_hsa009201.41771911
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39940112
38Folate biosynthesis_Homo sapiens_hsa007901.39463623
39mRNA surveillance pathway_Homo sapiens_hsa030151.38143261
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37645169
41Vitamin digestion and absorption_Homo sapiens_hsa049771.34848413
42ABC transporters_Homo sapiens_hsa020101.34172855
43Parkinsons disease_Homo sapiens_hsa050121.29257051
44RNA polymerase_Homo sapiens_hsa030201.27736773
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27628994
46One carbon pool by folate_Homo sapiens_hsa006701.24636213
47Oocyte meiosis_Homo sapiens_hsa041141.22070748
48Carbon metabolism_Homo sapiens_hsa012001.18731340
49Butanoate metabolism_Homo sapiens_hsa006501.17290374
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15987374
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.14972820
52p53 signaling pathway_Homo sapiens_hsa041151.14033040
53Histidine metabolism_Homo sapiens_hsa003401.11725053
54Autoimmune thyroid disease_Homo sapiens_hsa053201.11559524
55Ribosome_Homo sapiens_hsa030101.10420934
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.10403553
57Huntingtons disease_Homo sapiens_hsa050161.08808579
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07208804
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04846417
60Biosynthesis of amino acids_Homo sapiens_hsa012301.03797579
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02246116
62Hematopoietic cell lineage_Homo sapiens_hsa046401.01953380
63Protein digestion and absorption_Homo sapiens_hsa049741.00703066
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00157423
65Mismatch repair_Homo sapiens_hsa034300.99874235
66beta-Alanine metabolism_Homo sapiens_hsa004100.97676859
67Pyrimidine metabolism_Homo sapiens_hsa002400.94467630
68Taste transduction_Homo sapiens_hsa047420.93856252
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.92802290
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91746828
71Pancreatic secretion_Homo sapiens_hsa049720.91307225
72Asthma_Homo sapiens_hsa053100.89805900
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89153327
74Fatty acid metabolism_Homo sapiens_hsa012120.86650636
75Pentose phosphate pathway_Homo sapiens_hsa000300.85794306
76Primary immunodeficiency_Homo sapiens_hsa053400.81263563
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80580993
78Retinol metabolism_Homo sapiens_hsa008300.77120026
79Purine metabolism_Homo sapiens_hsa002300.76626645
80Lysine degradation_Homo sapiens_hsa003100.76131313
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75798501
82Allograft rejection_Homo sapiens_hsa053300.72922902
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71978942
84Arginine and proline metabolism_Homo sapiens_hsa003300.71767859
85Peroxisome_Homo sapiens_hsa041460.71026642
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70479128
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68842911
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.68324100
89Graft-versus-host disease_Homo sapiens_hsa053320.67827318
90Regulation of autophagy_Homo sapiens_hsa041400.67556952
91Tryptophan metabolism_Homo sapiens_hsa003800.67454425
92DNA replication_Homo sapiens_hsa030300.66284505
93N-Glycan biosynthesis_Homo sapiens_hsa005100.64787956
94Oxidative phosphorylation_Homo sapiens_hsa001900.61188547
95Alzheimers disease_Homo sapiens_hsa050100.61014413
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60913510
97Serotonergic synapse_Homo sapiens_hsa047260.60217304
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59339650
99Tyrosine metabolism_Homo sapiens_hsa003500.59270097
100Metabolic pathways_Homo sapiens_hsa011000.59006604
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58631904
102RNA degradation_Homo sapiens_hsa030180.57589676
103Measles_Homo sapiens_hsa051620.57426916
104Systemic lupus erythematosus_Homo sapiens_hsa053220.56650759
105Glutathione metabolism_Homo sapiens_hsa004800.56023076
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55720137
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50823883
108Epstein-Barr virus infection_Homo sapiens_hsa051690.50722849
109Sulfur relay system_Homo sapiens_hsa041220.48035422
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47213031
111Legionellosis_Homo sapiens_hsa051340.46650199
112Vitamin B6 metabolism_Homo sapiens_hsa007500.44833573
113Phenylalanine metabolism_Homo sapiens_hsa003600.44652658
114Fat digestion and absorption_Homo sapiens_hsa049750.43056148
115Base excision repair_Homo sapiens_hsa034100.42060534
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41203874
117Ovarian steroidogenesis_Homo sapiens_hsa049130.41055597
118Insulin secretion_Homo sapiens_hsa049110.40483107
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.40297954
120Complement and coagulation cascades_Homo sapiens_hsa046100.38375314
121Circadian rhythm_Homo sapiens_hsa047100.37203889
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37096453
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36852975
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36765310
125Nicotine addiction_Homo sapiens_hsa050330.35907138
126Herpes simplex infection_Homo sapiens_hsa051680.34408847
127Starch and sucrose metabolism_Homo sapiens_hsa005000.33643049
128Prostate cancer_Homo sapiens_hsa052150.32306211
129Basal cell carcinoma_Homo sapiens_hsa052170.32148667
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31539530
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30975337
132Viral carcinogenesis_Homo sapiens_hsa052030.30128272
133Melanoma_Homo sapiens_hsa052180.30065283
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28626432
135Rheumatoid arthritis_Homo sapiens_hsa053230.28560443
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.23830103
137Olfactory transduction_Homo sapiens_hsa047400.23587961
138Fructose and mannose metabolism_Homo sapiens_hsa000510.21823736
139Nitrogen metabolism_Homo sapiens_hsa009100.20591226
140Fatty acid degradation_Homo sapiens_hsa000710.19764226
141Thyroid cancer_Homo sapiens_hsa052160.19080543
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18586085
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.17596220
144TGF-beta signaling pathway_Homo sapiens_hsa043500.15494342
145Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14476382
146Inositol phosphate metabolism_Homo sapiens_hsa005620.12718486
147Shigellosis_Homo sapiens_hsa051310.11468125
148Small cell lung cancer_Homo sapiens_hsa052220.10276271
149MicroRNAs in cancer_Homo sapiens_hsa052060.09672650
150Vibrio cholerae infection_Homo sapiens_hsa051100.08850450
151Collecting duct acid secretion_Homo sapiens_hsa049660.08734967
152Fatty acid biosynthesis_Homo sapiens_hsa000610.04546807

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