RIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.58782548
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.98080291
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.90602205
4desmosome organization (GO:0002934)4.88538185
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.87728345
6skin morphogenesis (GO:0043589)4.87518292
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.85717703
8protein localization to endosome (GO:0036010)4.81106747
9cell-substrate junction assembly (GO:0007044)4.76306431
10locomotory exploration behavior (GO:0035641)4.75916032
11vocalization behavior (GO:0071625)4.72779013
12protein localization to synapse (GO:0035418)4.72155536
13regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53097754
14regulation of dendritic spine morphogenesis (GO:0061001)4.52216134
15glutamate receptor signaling pathway (GO:0007215)4.45944857
16barbed-end actin filament capping (GO:0051016)4.38465080
17regulation of glutamate receptor signaling pathway (GO:1900449)4.36641938
18synaptic vesicle exocytosis (GO:0016079)4.35527558
19endodermal cell differentiation (GO:0035987)4.31022836
20regulation of neuronal synaptic plasticity (GO:0048168)4.26307549
21cell adhesion mediated by integrin (GO:0033627)4.23289413
22neuron cell-cell adhesion (GO:0007158)4.19511236
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.18289941
24regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.16411944
25hypotonic response (GO:0006971)4.02758333
26synaptic transmission, glutamatergic (GO:0035249)3.98939249
27regulation of excitatory postsynaptic membrane potential (GO:0060079)3.98849737
28dendritic spine morphogenesis (GO:0060997)3.98083959
29neuron recognition (GO:0008038)3.96265588
30neuronal action potential propagation (GO:0019227)3.95561718
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.90830063
32exploration behavior (GO:0035640)3.89245651
33synaptic vesicle maturation (GO:0016188)3.89197279
34neuron-neuron synaptic transmission (GO:0007270)3.86731657
35glutamate secretion (GO:0014047)3.86432587
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.85538786
37negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.83663610
38protein retention in ER lumen (GO:0006621)3.82917495
39regulation of glutamate secretion (GO:0014048)3.81762765
40protein heterotrimerization (GO:0070208)3.80891727
41UV protection (GO:0009650)3.73781616
42regulation of dendritic spine development (GO:0060998)3.71241527
43positive regulation of dendritic spine morphogenesis (GO:0061003)3.70359062
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.70202029
45basement membrane organization (GO:0071711)3.68614584
46regulation of postsynaptic membrane potential (GO:0060078)3.67939805
47regulation of vesicle fusion (GO:0031338)3.66351040
48regulation of synaptic vesicle exocytosis (GO:2000300)3.64701231
49axonal fasciculation (GO:0007413)3.64035938
50regulation of synapse structural plasticity (GO:0051823)3.63320549
51long-term memory (GO:0007616)3.61659578
52dendritic spine organization (GO:0097061)3.60513080
53semaphorin-plexin signaling pathway (GO:0071526)3.59205187
54mesodermal cell differentiation (GO:0048333)3.59003646
55* regulation of synaptic plasticity (GO:0048167)3.58106532
56long-term synaptic potentiation (GO:0060291)3.57218122
57substrate-dependent cell migration (GO:0006929)3.57191397
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55035153
59transmission of nerve impulse (GO:0019226)3.52800687
60positive regulation of neurotransmitter secretion (GO:0001956)3.51936919
61dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.51175775
62gamma-aminobutyric acid signaling pathway (GO:0007214)3.45302038
63cellular response to vitamin (GO:0071295)3.45217532
64endothelial cell chemotaxis (GO:0035767)3.44754807
65synaptic transmission, dopaminergic (GO:0001963)3.43333095
66positive regulation of dendritic spine development (GO:0060999)3.43195761
67cellular response to vitamin D (GO:0071305)3.43150540
68regulation of apoptotic process involved in morphogenesis (GO:1902337)3.42510068
69endothelial cell morphogenesis (GO:0001886)3.41008458
70positive regulation of fibroblast migration (GO:0010763)3.37926798
71behavioral fear response (GO:0001662)3.37721256
72behavioral defense response (GO:0002209)3.37721256
73positive regulation of synapse maturation (GO:0090129)3.32333881
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31562871
75chondrocyte proliferation (GO:0035988)3.31326782
76Golgi transport vesicle coating (GO:0048200)3.31018915
77COPI coating of Golgi vesicle (GO:0048205)3.31018915
78type B pancreatic cell proliferation (GO:0044342)3.30927325
79response to gravity (GO:0009629)3.29714616
80heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.28961537
81positive regulation of blood vessel endothelial cell migration (GO:0043536)3.28281635
82ephrin receptor signaling pathway (GO:0048013)3.27878346
83layer formation in cerebral cortex (GO:0021819)3.27775427
84regulation of early endosome to late endosome transport (GO:2000641)3.27296742
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.26623898
86positive regulation of membrane potential (GO:0045838)3.25414137
87kidney mesenchyme development (GO:0072074)3.25409750
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24083496
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24066814
90negative regulation of amino acid transport (GO:0051956)3.23481273
91positive regulation of neurotransmitter transport (GO:0051590)3.23449097
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.21002945
93focal adhesion assembly (GO:0048041)3.20915413
94cell-substrate adherens junction assembly (GO:0007045)3.20915413
95fear response (GO:0042596)3.18818860
96postsynaptic membrane organization (GO:0001941)3.18447940
97neurotransmitter-gated ion channel clustering (GO:0072578)3.17174270
98presynaptic membrane assembly (GO:0097105)3.16324003
99neuromuscular process controlling balance (GO:0050885)3.16110066
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15515087
101regulation of synaptic vesicle transport (GO:1902803)3.15157469
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.14988935
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14178598
104endocytic recycling (GO:0032456)3.13966674
105tooth mineralization (GO:0034505)3.11333922
106response to histamine (GO:0034776)3.11134825
107membrane raft organization (GO:0031579)3.09118298
108pinocytosis (GO:0006907)3.08171293
109behavioral response to cocaine (GO:0048148)3.05843059
110activation of Rac GTPase activity (GO:0032863)3.03512241
111negative regulation of chondrocyte differentiation (GO:0032331)3.03165101
112positive regulation of synapse assembly (GO:0051965)3.02419590
113* learning (GO:0007612)3.01367001
114presynaptic membrane organization (GO:0097090)3.00767535
115stress fiber assembly (GO:0043149)3.00501190
116membrane depolarization (GO:0051899)3.00028668
117planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99433667
118response to amphetamine (GO:0001975)2.98549413
119regulation of protein kinase A signaling (GO:0010738)2.98190710
120adherens junction assembly (GO:0034333)2.97747968
121cell migration involved in heart development (GO:0060973)2.97455468
122positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95426276
123positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.95411412
124protein hydroxylation (GO:0018126)2.95303096
125virion attachment to host cell (GO:0019062)2.93874331
126adhesion of symbiont to host cell (GO:0044650)2.93874331
127neurotransmitter secretion (GO:0007269)2.93855559
128negative regulation of axon extension involved in axon guidance (GO:0048843)2.90823408
129positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89302877
130regulation of extracellular matrix disassembly (GO:0010715)2.89018731
131wound healing, spreading of epidermal cells (GO:0035313)2.88463836
132actin filament depolymerization (GO:0030042)2.87297246
133glial cell migration (GO:0008347)2.85192068
134prepulse inhibition (GO:0060134)2.84748427
135neuronal ion channel clustering (GO:0045161)2.83652278
136vascular endothelial growth factor signaling pathway (GO:0038084)2.82477025
137regulation of neurotransmitter secretion (GO:0046928)2.81832816
138collagen metabolic process (GO:0032963)2.81451485
139protein maturation by protein folding (GO:0022417)2.81283684
140muscle cell migration (GO:0014812)2.80819292
141regulation of dendrite morphogenesis (GO:0048814)2.80442260
142regulation of synapse organization (GO:0050807)2.78172180
143actin filament bundle organization (GO:0061572)2.77458840
144actin filament bundle assembly (GO:0051017)2.77458840
145synaptic vesicle endocytosis (GO:0048488)2.77099390
146positive regulation of dendrite development (GO:1900006)2.76965292
147regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76840070
148keratinocyte proliferation (GO:0043616)2.76024097
149regulation of voltage-gated calcium channel activity (GO:1901385)2.76021133
150regulation of synapse maturation (GO:0090128)2.75900831
151peptidyl-proline hydroxylation (GO:0019511)2.74812110
152positive regulation of synaptic transmission (GO:0050806)2.74757690
153fibril organization (GO:0097435)2.73548998
154* regulation of synaptic transmission (GO:0050804)2.73368622
155regulation of mammary gland epithelial cell proliferation (GO:0033599)2.73261265
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72998410
157mammary gland epithelial cell proliferation (GO:0033598)2.72344548
158adhesion of symbiont to host (GO:0044406)2.72190755
159nerve growth factor signaling pathway (GO:0038180)2.71999651
160* memory (GO:0007613)2.71746786
161hyaluronan catabolic process (GO:0030214)2.71711994
162positive regulation of dendrite morphogenesis (GO:0050775)2.70829655
163pattern specification involved in kidney development (GO:0061004)2.70687926
164positive regulation of vesicle fusion (GO:0031340)2.70599074
165collagen fibril organization (GO:0030199)2.70296851
166auditory behavior (GO:0031223)2.70153547
167extracellular fibril organization (GO:0043206)2.69555124
168mannose metabolic process (GO:0006013)2.69322975
169dendrite morphogenesis (GO:0048813)2.68642315
170neuromuscular process (GO:0050905)2.65968036
171regulation of synapse assembly (GO:0051963)2.65335453
172heparan sulfate proteoglycan metabolic process (GO:0030201)2.65289095
173nuclear envelope reassembly (GO:0031468)2.65199100
174mitotic nuclear envelope reassembly (GO:0007084)2.65199100
175regulation of neurotransmitter transport (GO:0051588)2.64748473
176* learning or memory (GO:0007611)2.64717121
177synapse organization (GO:0050808)2.63987984
178extracellular matrix disassembly (GO:0022617)2.63814307
179venous blood vessel morphogenesis (GO:0048845)2.61909316
180wound healing, spreading of cells (GO:0044319)2.61771224
181regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61272141
182positive regulation of axon extension (GO:0045773)2.61216021
183mesenchymal-epithelial cell signaling (GO:0060638)2.60504073
184collagen catabolic process (GO:0030574)2.59348772
185facial nerve structural organization (GO:0021612)2.58653504
186negative regulation of smooth muscle cell migration (GO:0014912)2.55559878
187extracellular matrix assembly (GO:0085029)2.54996100
188regulation of metalloenzyme activity (GO:0048552)2.54500161
189sequestering of extracellular ligand from receptor (GO:0035581)2.54371536
190decidualization (GO:0046697)2.54101051
191bone trabecula formation (GO:0060346)2.53580486
192negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.52575205
193apoptotic cell clearance (GO:0043277)2.50470353
194negative regulation of stem cell proliferation (GO:2000647)2.49877265
195response to progesterone (GO:0032570)2.49799646
196multicellular organismal macromolecule metabolic process (GO:0044259)2.48851576
197lung morphogenesis (GO:0060425)2.47914105
198regulation of anoikis (GO:2000209)2.47901863
199positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.47781614
200response to magnesium ion (GO:0032026)2.47002044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.67778305
2EZH2_22144423_ChIP-Seq_EOC_Human5.73472843
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.34866437
4GBX2_23144817_ChIP-Seq_PC3_Human3.51208071
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.33028380
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.25434787
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.23679391
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23432102
9* ELK3_25401928_ChIP-Seq_HUVEC_Human2.98767818
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.96210197
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.96210197
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.93238021
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.84398579
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70563498
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.67861220
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.67277500
17* LXR_22292898_ChIP-Seq_THP-1_Human2.60983422
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.59300105
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58433804
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54988493
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51460286
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.39464269
23ZNF263_19887448_ChIP-Seq_K562_Human2.34496398
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32078656
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.31278418
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.29321216
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23170076
28RACK7_27058665_Chip-Seq_MCF-7_Human2.22871631
29* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.20577677
30REST_21632747_ChIP-Seq_MESCs_Mouse2.17757569
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16788098
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13998819
33VDR_21846776_ChIP-Seq_THP-1_Human2.10158712
34DROSHA_22980978_ChIP-Seq_HELA_Human2.08967298
35IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04165200
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02676186
37UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human2.01590883
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97476419
39TP53_22127205_ChIP-Seq_IMR90_Human1.95074367
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91791942
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.90540269
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90162185
43ATF3_27146783_Chip-Seq_COLON_Human1.89272663
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84486544
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80909672
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80898769
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79240109
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75860128
49AR_21572438_ChIP-Seq_LNCaP_Human1.75539532
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72432707
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72099117
52* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.71969830
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69992072
54* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69892805
55* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69892805
56TP53_16413492_ChIP-PET_HCT116_Human1.69518694
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.69248956
58* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.68112203
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67830657
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66921077
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66836520
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.66560004
63* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65590987
64* TET1_21451524_ChIP-Seq_MESCs_Mouse1.62644471
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.61799469
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61432672
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61404220
68TAF15_26573619_Chip-Seq_HEK293_Human1.60523501
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.60422640
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57898842
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52207707
72ZNF274_21170338_ChIP-Seq_K562_Hela1.48312059
73SMAD4_21799915_ChIP-Seq_A2780_Human1.45931410
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45803354
75P68_20966046_ChIP-Seq_HELA_Human1.45458073
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43952093
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43557556
78* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43358529
79KDM2B_26808549_Chip-Seq_DND41_Human1.40917623
80TP53_18474530_ChIP-ChIP_U2OS_Human1.40640860
81* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40108352
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.40068645
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39786534
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.39687136
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38825333
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38734503
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.36724351
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35892392
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35518152
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.32794467
91* SA1_27219007_Chip-Seq_ERYTHROID_Human1.31394922
92* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.30416108
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30275654
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30176325
95* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30150220
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28493093
97P300_19829295_ChIP-Seq_ESCs_Human1.28102936
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.27007331
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26891352
100* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.26483400
101* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26099016
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25338134
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.25320712
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25202521
105TCF7_22412390_ChIP-Seq_EML_Mouse1.24434357
106* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23944590
107CLOCK_20551151_ChIP-Seq_293T_Human1.22136370
108* SMC4_20622854_ChIP-Seq_HELA_Human1.21696432
109* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21558930
110* TP53_23651856_ChIP-Seq_MEFs_Mouse1.21186583
111* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21009171
112VDR_24763502_ChIP-Seq_THP-1_Human1.20046120
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.19541779
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19321741
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19299530
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18847898
117FUS_26573619_Chip-Seq_HEK293_Human1.18647296
118* TP53_20018659_ChIP-ChIP_R1E_Mouse1.17002075
119TP63_22573176_ChIP-Seq_HFKS_Human1.15511661
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12871236
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12554728
122GATA2_21666600_ChIP-Seq_HMVEC_Human1.11881224
123* TET1_21490601_ChIP-Seq_MESCs_Mouse1.11816918
124GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11811346
125BRD4_25478319_ChIP-Seq_HGPS_Human1.11391891
126KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11087893
127WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11051779
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11024487
129BCOR_27268052_Chip-Seq_Bcells_Human1.11021694
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10694816
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10674241
132NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10117021
133PIAS1_25552417_ChIP-Seq_VCAP_Human1.09132969
134ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08900729
135VDR_22108803_ChIP-Seq_LS180_Human1.08444804
136BCL6_27268052_Chip-Seq_Bcells_Human1.07180585
137KDM2B_26808549_Chip-Seq_JURKAT_Human1.05604877
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05513434
139SOX2_21211035_ChIP-Seq_LN229_Gbm1.05039337
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04058273
141JUN_21703547_ChIP-Seq_K562_Human1.04058141
142RNF2_27304074_Chip-Seq_NSC_Mouse1.03178919
143AR_25329375_ChIP-Seq_VCAP_Human1.02348819
144SMAD3_21741376_ChIP-Seq_HESCs_Human1.01678446
145MYC_22102868_ChIP-Seq_BL_Human1.01660483
146AR_19668381_ChIP-Seq_PC3_Human1.00793778
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00428561
148STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00044413
149CREB1_26743006_Chip-Seq_LNCaP_Human1.00017837
150ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99556194
151CTCF_27219007_Chip-Seq_Bcells_Human0.98156810
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97707788
153RARA_24833708_ChIP-Seq_LIVER_Mouse0.97417355
154* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97302913
155CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97040681
156SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96927215
157NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96839113
158NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96839113
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96721809
160* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96711675
161EP300_21415370_ChIP-Seq_HL-1_Mouse0.96247187
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.96055290
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95491277
164TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95188202
165EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95179481
166* RARB_24833708_ChIP-Seq_LIVER_Mouse0.95158333
167CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95156448
168* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94729002
169ARNT_22903824_ChIP-Seq_MCF-7_Human0.93402740
170SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93083588
171IGF1R_20145208_ChIP-Seq_DFB_Human0.92650149
172STAT3_23295773_ChIP-Seq_U87_Human0.92545179
173BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92535563
174ESR1_21235772_ChIP-Seq_MCF-7_Human0.92531369
175SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92204209
176AHR_22903824_ChIP-Seq_MCF-7_Human0.91970717
177E2F1_20622854_ChIP-Seq_HELA_Human0.91334437
178RUNX2_22187159_ChIP-Seq_PCA_Human0.90588959
179CJUN_26792858_Chip-Seq_BT549_Human0.89989536
180MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89674845
181RUNX1_22412390_ChIP-Seq_EML_Mouse0.89494060
182TCF4_23295773_ChIP-Seq_U87_Human0.89205645
183DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88977535
184P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88828888
185ER_23166858_ChIP-Seq_MCF-7_Human0.88457924
186ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86918632
187RXR_22108803_ChIP-Seq_LS180_Human0.85139183
188YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84675481
189KDM2B_26808549_Chip-Seq_K562_Human0.83597980
190POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81922830
191POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81137746
192TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81137746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.64402671
2MP0003880_abnormal_central_pattern5.42958177
3MP0003705_abnormal_hypodermis_morpholog4.90836523
4MP0003635_abnormal_synaptic_transmissio3.85249893
5MP0004270_analgesia3.48721795
6MP0005257_abnormal_intraocular_pressure3.39496291
7MP0009745_abnormal_behavioral_response3.21028357
8MP0002063_abnormal_learning/memory/cond3.13460231
9MP0003566_abnormal_cell_adhesion3.07514128
10MP0002822_catalepsy2.91005274
11MP0001968_abnormal_touch/_nociception2.81114672
12MP0002064_seizures2.75647647
13MP0003279_aneurysm2.67246358
14MP0002572_abnormal_emotion/affect_behav2.60888178
15MP0001958_emphysema2.60809613
16MP0002060_abnormal_skin_morphology2.60506482
17MP0002877_abnormal_melanocyte_morpholog2.58970085
18MP0005023_abnormal_wound_healing2.43321229
19MP0005423_abnormal_somatic_nervous2.43254115
20MP0002736_abnormal_nociception_after2.39779769
21MP0005058_abnormal_lysosome_morphology2.39197737
22MP0010030_abnormal_orbit_morphology2.37166582
23MP0001486_abnormal_startle_reflex2.35280109
24MP0002272_abnormal_nervous_system2.33174788
25MP0001849_ear_inflammation2.30352276
26MP0009046_muscle_twitch2.26070370
27MP0005623_abnormal_meninges_morphology2.23831349
28MP0003950_abnormal_plasma_membrane2.17947274
29MP0001542_abnormal_bone_strength2.17366174
30MP0001440_abnormal_grooming_behavior2.11037929
31MP0000579_abnormal_nail_morphology2.10617748
32MP0009840_abnormal_foam_cell2.08207632
33MP0002734_abnormal_mechanical_nocicepti2.02622365
34MP0003453_abnormal_keratinocyte_physiol2.02229492
35MP0003191_abnormal_cellular_cholesterol1.95164197
36MP0002735_abnormal_chemical_nociception1.93271762
37MP0009053_abnormal_anal_canal1.87648931
38MP0001501_abnormal_sleep_pattern1.82438017
39MP0010234_abnormal_vibrissa_follicle1.79277868
40MP0005501_abnormal_skin_physiology1.78160673
41MP0002796_impaired_skin_barrier1.77918495
42MP0001188_hyperpigmentation1.70709923
43MP0003329_amyloid_beta_deposits1.68995211
44MP0000778_abnormal_nervous_system1.66697759
45MP0010368_abnormal_lymphatic_system1.62556489
46MP0000750_abnormal_muscle_regeneration1.59948020
47MP0000003_abnormal_adipose_tissue1.58439472
48MP0001970_abnormal_pain_threshold1.57192537
49MP0005409_darkened_coat_color1.57009536
50MP0001216_abnormal_epidermal_layer1.55273407
51MP0001529_abnormal_vocalization1.54898808
52MP0002184_abnormal_innervation1.51309071
53MP0000467_abnormal_esophagus_morphology1.50362562
54MP0001243_abnormal_dermal_layer1.49817506
55MP0009780_abnormal_chondrocyte_physiolo1.48601812
56MP0002733_abnormal_thermal_nociception1.47749342
57MP0000013_abnormal_adipose_tissue1.47640869
58MP0000767_abnormal_smooth_muscle1.45098720
59MP0000733_abnormal_muscle_development1.43402703
60MP0002067_abnormal_sensory_capabilities1.43328345
61MP0002896_abnormal_bone_mineralization1.41783785
62MP0010771_integument_phenotype1.41693022
63MP0005508_abnormal_skeleton_morphology1.41608721
64MP0004811_abnormal_neuron_physiology1.39875237
65MP0002234_abnormal_pharynx_morphology1.38651098
66MP0001905_abnormal_dopamine_level1.35499080
67MP0004510_myositis1.33909117
68MP0005451_abnormal_body_composition1.33526246
69MP0000858_altered_metastatic_potential1.31782314
70MP0002557_abnormal_social/conspecific_i1.31362004
71MP0009384_cardiac_valve_regurgitation1.30723105
72MP0003172_abnormal_lysosome_physiology1.30173263
73MP0005360_urolithiasis1.30094263
74MP0008260_abnormal_autophagy1.29322636
75MP0002882_abnormal_neuron_morphology1.27300067
76MP0000955_abnormal_spinal_cord1.25856825
77MP0008569_lethality_at_weaning1.24533838
78MP0009379_abnormal_foot_pigmentation1.24179191
79MP0005171_absent_coat_pigmentation1.22977260
80MP0002066_abnormal_motor_capabilities/c1.21482001
81MP0000343_altered_response_to1.21017483
82MP0002089_abnormal_postnatal_growth/wei1.17971781
83MP0008438_abnormal_cutaneous_collagen1.17259293
84MP0006054_spinal_hemorrhage1.17225722
85MP0004145_abnormal_muscle_electrophysio1.17013514
86MP0004858_abnormal_nervous_system1.14900863
87MP0004947_skin_inflammation1.14008752
88MP0005386_behavior/neurological_phenoty1.12530888
89MP0004924_abnormal_behavior1.12530888
90MP0005390_skeleton_phenotype1.08880353
91MP0000751_myopathy1.08443417
92MP0005164_abnormal_response_to1.08419775
93MP0005083_abnormal_biliary_tract1.07401008
94MP0003879_abnormal_hair_cell1.04200052
95MP0001177_atelectasis1.04012730
96MP0006276_abnormal_autonomic_nervous1.03548355
97MP0002152_abnormal_brain_morphology1.03050876
98MP0002998_abnormal_bone_remodeling1.02424820
99MP0001299_abnormal_eye_distance/1.01388851
100MP0000534_abnormal_ureter_morphology1.01287229
101MP0000920_abnormal_myelination0.97917793
102MP0003941_abnormal_skin_development0.97466578
103MP0000749_muscle_degeneration0.97026703
104MP0000678_abnormal_parathyroid_gland0.96579214
105MP0004742_abnormal_vestibular_system0.96051774
106MP0002295_abnormal_pulmonary_circulatio0.95608376
107MP0004885_abnormal_endolymph0.94828049
108MP0003436_decreased_susceptibility_to0.94247748
109MP0003633_abnormal_nervous_system0.94072633
110MP0005076_abnormal_cell_differentiation0.93537507
111MP0002909_abnormal_adrenal_gland0.93280119
112MP0000759_abnormal_skeletal_muscle0.92337824
113MP0003631_nervous_system_phenotype0.92044774
114MP0004233_abnormal_muscle_weight0.91800622
115MP0003091_abnormal_cell_migration0.89697948
116MP0004185_abnormal_adipocyte_glucose0.89576126
117MP0001533_abnormal_skeleton_physiology0.89035142
118MP0003283_abnormal_digestive_organ0.87759250
119MP0005197_abnormal_uvea_morphology0.85501847
120MP0003123_paternal_imprinting0.84988401
121MP0003075_altered_response_to0.84833939
122MP0004085_abnormal_heartbeat0.84245538
123MP0001485_abnormal_pinna_reflex0.83759698
124MP0005165_increased_susceptibility_to0.83699400
125MP0003122_maternal_imprinting0.82739896
126MP0003828_pulmonary_edema0.82722629
127MP0003634_abnormal_glial_cell0.82545946
128MP0003938_abnormal_ear_development0.82505058
129MP0008874_decreased_physiological_sensi0.82479182
130MP0008004_abnormal_stomach_pH0.82251010
131MP0000537_abnormal_urethra_morphology0.81975117
132MP0003806_abnormal_nucleotide_metabolis0.81848240
133MP0009931_abnormal_skin_appearance0.81367688
134MP0005275_abnormal_skin_tensile0.79742411
135MP0001984_abnormal_olfaction0.79741402
136MP0005503_abnormal_tendon_morphology0.79324634
137MP0001348_abnormal_lacrimal_gland0.79123698
138MP0006292_abnormal_olfactory_placode0.76957751
139MP0004142_abnormal_muscle_tone0.76921586
140MP0003632_abnormal_nervous_system0.75414847
141MP0005646_abnormal_pituitary_gland0.75266357
142MP0001664_abnormal_digestion0.75256425
143MP0005375_adipose_tissue_phenotype0.74528439
144MP0001502_abnormal_circadian_rhythm0.74491869
145MP0005193_abnormal_anterior_eye0.73323991
146MP0009250_abnormal_appendicular_skeleto0.73055478
147MP0002752_abnormal_somatic_nervous0.73043695
148MP0003448_altered_tumor_morphology0.71822255
149MP0010352_gastrointestinal_tract_polyps0.71238944
150MP0002113_abnormal_skeleton_development0.70300156
151MP0004272_abnormal_basement_membrane0.69645223
152MP0000538_abnormal_urinary_bladder0.69640675
153MP0005394_taste/olfaction_phenotype0.69542659
154MP0005499_abnormal_olfactory_system0.69542659
155MP0003385_abnormal_body_wall0.69451690
156MP0001963_abnormal_hearing_physiology0.69162107
157MP0002837_dystrophic_cardiac_calcinosis0.68037204
158MP0003795_abnormal_bone_structure0.67834558
159MP0000163_abnormal_cartilage_morphology0.67833816
160MP0005595_abnormal_vascular_smooth0.67225705
161MP0000747_muscle_weakness0.66369166
162MP0003861_abnormal_nervous_system0.65784670
163MP0002069_abnormal_eating/drinking_beha0.65291884
164MP0005410_abnormal_fertilization0.65058234
165MP0003755_abnormal_palate_morphology0.64298511
166MP0000428_abnormal_craniofacial_morphol0.63334248
167MP0005551_abnormal_eye_electrophysiolog0.63054568
168MP0004484_altered_response_of0.63031796
169MP0005621_abnormal_cell_physiology0.62955336
170MP0001943_abnormal_respiration0.62289981
171MP0003137_abnormal_impulse_conducting0.61930804
172MP0002177_abnormal_outer_ear0.61783783
173MP0002090_abnormal_vision0.61247071
174MP0003942_abnormal_urinary_system0.61095552
175MP0000762_abnormal_tongue_morphology0.59242460
176MP0001853_heart_inflammation0.58947346
177MP0001879_abnormal_lymphatic_vessel0.58133535
178MP0010386_abnormal_urinary_bladder0.57972028
179MP0002229_neurodegeneration0.57947074
180MP0008872_abnormal_physiological_respon0.57751209

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.92388196
2Myokymia (HP:0002411)6.29166488
3Focal seizures (HP:0007359)4.70188931
4Ankle contracture (HP:0006466)4.16705978
5Atonic seizures (HP:0010819)4.01098618
6Vertebral compression fractures (HP:0002953)3.89371961
7Fragile skin (HP:0001030)3.80423485
8Follicular hyperkeratosis (HP:0007502)3.77708451
9Broad-based gait (HP:0002136)3.63140163
10Visual hallucinations (HP:0002367)3.61199695
11Epileptic encephalopathy (HP:0200134)3.57290393
12Absence seizures (HP:0002121)3.38830889
13Increased connective tissue (HP:0009025)3.38091058
14Cervical subluxation (HP:0003308)3.36834419
15Cerebral inclusion bodies (HP:0100314)3.26852428
16Dialeptic seizures (HP:0011146)3.24853610
17Natal tooth (HP:0000695)3.22577037
18Elbow flexion contracture (HP:0002987)3.14988127
19Short nail (HP:0001799)3.08872454
20Milia (HP:0001056)3.02598495
21Bladder diverticulum (HP:0000015)3.02338092
22Fragile nails (HP:0001808)2.99700331
23Entropion (HP:0000621)2.99315177
24Hyperventilation (HP:0002883)2.97694895
25Type 1 muscle fiber predominance (HP:0003803)2.95934526
26Mildly elevated creatine phosphokinase (HP:0008180)2.94751083
27Lower limb amyotrophy (HP:0007210)2.94666821
28Febrile seizures (HP:0002373)2.92654726
29Distal lower limb muscle weakness (HP:0009053)2.91542985
30Slender build (HP:0001533)2.90718843
31Ulnar bowing (HP:0003031)2.88888601
32Poor eye contact (HP:0000817)2.88211386
33Dysdiadochokinesis (HP:0002075)2.86304988
34Hyperacusis (HP:0010780)2.83812389
35Premature rupture of membranes (HP:0001788)2.81509098
36Distal lower limb amyotrophy (HP:0008944)2.81125986
37Abnormality of the Achilles tendon (HP:0005109)2.80147547
38Protrusio acetabuli (HP:0003179)2.77943761
39Amblyopia (HP:0000646)2.76627631
40Wormian bones (HP:0002645)2.74407175
41Generalized amyotrophy (HP:0003700)2.74099228
42Dysmetria (HP:0001310)2.72659669
43Aortic dissection (HP:0002647)2.69391438
44Neurofibrillary tangles (HP:0002185)2.68408648
45Progressive cerebellar ataxia (HP:0002073)2.68097592
46Generalized tonic-clonic seizures (HP:0002069)2.62959673
47Hydroureter (HP:0000072)2.61465167
48Aortic aneurysm (HP:0004942)2.61053788
49Arterial tortuosity (HP:0005116)2.55563527
50Alopecia of scalp (HP:0002293)2.55294787
51Thick nail (HP:0001805)2.51627685
52Cardiovascular calcification (HP:0011915)2.51518432
53Joint stiffness (HP:0001387)2.50722617
54Abnormality of liposaccharide metabolism (HP:0010968)2.49715837
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.49715837
56Abnormality of glycolipid metabolism (HP:0010969)2.49715837
57Reduced subcutaneous adipose tissue (HP:0003758)2.45781531
58Hand muscle atrophy (HP:0009130)2.44699146
59Buphthalmos (HP:0000557)2.43157582
60Blue sclerae (HP:0000592)2.43131617
61Nail dystrophy (HP:0008404)2.40369648
62Gaze-evoked nystagmus (HP:0000640)2.38888761
63Fetal akinesia sequence (HP:0001989)2.38610934
64Abnormal social behavior (HP:0012433)2.38421267
65Impaired social interactions (HP:0000735)2.38421267
66Cerebral aneurysm (HP:0004944)2.38018545
67Broad face (HP:0000283)2.37469562
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.36159703
69Osteolytic defects of the hand bones (HP:0009699)2.36159703
70Abnormality of dentin (HP:0010299)2.35888584
71Axonal loss (HP:0003447)2.34631898
72Impaired vibration sensation in the lower limbs (HP:0002166)2.34421553
73Abnormality of the distal phalanges of the toes (HP:0010182)2.34173237
74Supranuclear gaze palsy (HP:0000605)2.33474426
75Action tremor (HP:0002345)2.32549882
76Anxiety (HP:0000739)2.31060540
77Megalencephaly (HP:0001355)2.30433291
78Truncal ataxia (HP:0002078)2.29687386
79Bowing of the arm (HP:0006488)2.29618467
80Bowed forearm bones (HP:0003956)2.29618467
81Aplasia involving bones of the extremities (HP:0009825)2.29188193
82Aplasia involving bones of the upper limbs (HP:0009823)2.29188193
83Aplasia of the phalanges of the hand (HP:0009802)2.29188193
84Mitral regurgitation (HP:0001653)2.28834957
85Spondylolisthesis (HP:0003302)2.26902375
86Trismus (HP:0000211)2.23570769
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.23517412
88Absent/shortened dynein arms (HP:0200106)2.23517412
89Depression (HP:0000716)2.22649603
90Shallow orbits (HP:0000586)2.21002376
91Stereotypic behavior (HP:0000733)2.20214711
92Aortic regurgitation (HP:0001659)2.19674256
93Vascular calcification (HP:0004934)2.17072681
94Soft skin (HP:0000977)2.17003529
95Hemiparesis (HP:0001269)2.15392160
96Plantar hyperkeratosis (HP:0007556)2.14890022
97Delusions (HP:0000746)2.14210386
98Mitral stenosis (HP:0001718)2.13448545
99Long toe (HP:0010511)2.12247282
100Atrophic scars (HP:0001075)2.10607225
101Bronchomalacia (HP:0002780)2.07958124
102Dysostosis multiplex (HP:0000943)2.07716253
103Abnormality of the lower motor neuron (HP:0002366)2.03706963
104Ankyloglossia (HP:0010296)2.03297699
105Absent speech (HP:0001344)2.03145955
106Annular pancreas (HP:0001734)2.02553817
107Rapidly progressive (HP:0003678)1.99759232
108Abnormality of skeletal muscle fiber size (HP:0012084)1.99092933
109Achilles tendon contracture (HP:0001771)1.98554545
110Retinal dysplasia (HP:0007973)1.96760171
111Decreased subcutaneous fat (HP:0001002)1.95198285
112Biconcave vertebral bodies (HP:0004586)1.93929625
113Increased variability in muscle fiber diameter (HP:0003557)1.93818712
114Selective tooth agenesis (HP:0001592)1.92047621
115Ankle clonus (HP:0011448)1.91046691
116Insomnia (HP:0100785)1.90619810
117Rough bone trabeculation (HP:0100670)1.90128621
118Spinal cord lesions (HP:0100561)1.89681260
119Syringomyelia (HP:0003396)1.89681260
120Diplopia (HP:0000651)1.88661350
121Abnormality of binocular vision (HP:0011514)1.88661350
122Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88289924
123Infantile muscular hypotonia (HP:0008947)1.87739574
124Palpebral edema (HP:0100540)1.87585178
125Peritonitis (HP:0002586)1.87333267
126Abnormality of oral frenula (HP:0000190)1.87187481
127Nuclear cataract (HP:0100018)1.86663960
128Disproportionate tall stature (HP:0001519)1.86335815
129Broad metatarsal (HP:0001783)1.86136881
130Obstructive sleep apnea (HP:0002870)1.86019149
131Difficulty climbing stairs (HP:0003551)1.84833433
132Scanning speech (HP:0002168)1.84269392
133Stridor (HP:0010307)1.84133758
134Thin bony cortex (HP:0002753)1.82793624
135Urinary bladder sphincter dysfunction (HP:0002839)1.82051170
136Excessive salivation (HP:0003781)1.81004955
137Drooling (HP:0002307)1.81004955
138Radial bowing (HP:0002986)1.80782906
139Pointed chin (HP:0000307)1.80670738
140Advanced eruption of teeth (HP:0006288)1.80564751
141Thickened helices (HP:0000391)1.80268165
142Torticollis (HP:0000473)1.79815554
143Coronal craniosynostosis (HP:0004440)1.79430967
144Exotropia (HP:0000577)1.79346686
145Onycholysis (HP:0001806)1.79301430
146Poikiloderma (HP:0001029)1.79167114
147Aneurysm (HP:0002617)1.78794942
148Coxa vara (HP:0002812)1.78686757
149Abnormality of nail color (HP:0100643)1.77894606
150Glucose intolerance (HP:0000833)1.77242662
151Short clavicles (HP:0000894)1.77200047
152Hypoventilation (HP:0002791)1.77017223
153Joint laxity (HP:0001388)1.76989776
154Distal upper limb amyotrophy (HP:0007149)1.76593248
155Upper limb amyotrophy (HP:0009129)1.76593248
156Termporal pattern (HP:0011008)1.75982519
157Insidious onset (HP:0003587)1.75982519
158Congenital glaucoma (HP:0001087)1.75549960
159Renal duplication (HP:0000075)1.75158870
160Truncus arteriosus (HP:0001660)1.74453264
161Neonatal short-limb short stature (HP:0008921)1.74422791
162Abnormality of the acetabulum (HP:0003170)1.74384032
163Lower limb asymmetry (HP:0100559)1.74371460
164Sensory axonal neuropathy (HP:0003390)1.74086088
165Overgrowth (HP:0001548)1.72647754
166Abnormal eating behavior (HP:0100738)1.72197878
167Hypoplastic nipples (HP:0002557)1.72045999
168Focal dystonia (HP:0004373)1.71750200
169Type II lissencephaly (HP:0007260)1.70863742
170Genetic anticipation (HP:0003743)1.69023271
171Vascular tortuosity (HP:0004948)1.67926876
172Dilatation of the ascending aorta (HP:0005111)1.67838132
173Genu recurvatum (HP:0002816)1.66583027
174Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66442661
175Degeneration of the lateral corticospinal tracts (HP:0002314)1.66442661
176Impaired smooth pursuit (HP:0007772)1.65680898
177Generalized myoclonic seizures (HP:0002123)1.65008267
178Incomplete penetrance (HP:0003829)1.64410988
179Spinal rigidity (HP:0003306)1.63873444
180Abnormal ciliary motility (HP:0012262)1.61786861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.39418227
2NTRK34.48039882
3MAP3K92.93826882
4NME22.93288298
5IRAK32.90907480
6ERN12.87203717
7RIPK42.77714292
8TRIB32.71903362
9TESK12.54679349
10SIK12.54381531
11PRKD32.33767761
12KSR22.29197351
13PTK2B2.23565371
14LMTK22.04856876
15PAK42.03338396
16MINK12.02247919
17PRPF4B1.99510126
18PAK61.97989797
19ARAF1.96702779
20MAP2K31.93439222
21EPHB21.91264698
22PLK21.85792021
23ICK1.85013388
24RIPK11.77671942
25NTRK11.77501705
26EPHB11.72235281
27KSR11.70526510
28CASK1.70097363
29LATS21.69756472
30MAP3K41.69430104
31TESK21.66726101
32PIM21.63632768
33DAPK21.61911297
34PNCK1.58018033
35CAMKK11.57144000
36FLT31.52784186
37DDR21.48421797
38MAP3K31.46959845
39TGFBR21.42613219
40CDK51.42454033
41MOS1.40265045
42BMPR21.39973438
43CAMK2B1.39689676
44MYLK1.38277461
45SMG11.37399267
46MAP3K131.37064012
47CAMKK21.36241594
48FES1.35237798
49MARK11.34455615
50CDK191.32037636
51NME11.31383149
52FGR1.29528332
53GRK51.26764930
54MAP3K111.26502548
55MAP2K71.25495966
56CAMK2A1.25141365
57MAP3K21.23740559
58MAPKAPK31.22623557
59PTK61.21436701
60TLK11.21432816
61MAP3K121.20023112
62NTRK21.18513959
63ERBB41.14895327
64RAF11.13926473
65TYRO31.12783971
66STK391.12222554
67TNIK1.10948209
68CDK141.06704200
69DAPK11.06601134
70PAK31.05472062
71CDK151.05456628
72CDK181.03718963
73PRKCG1.01884576
74* ABL21.00657116
75SIK20.99414635
76OXSR10.97358888
77ROCK20.93762267
78CDK11A0.93645102
79EPHA20.93528045
80BMX0.92965927
81MAP2K40.90758506
82TNK20.89187644
83RPS6KA20.88110598
84MAP3K60.88081466
85CAMK2D0.87447201
86MAP2K10.86890166
87FER0.86603848
88ILK0.85729983
89CDK80.85215405
90PRKG20.84023117
91STK380.83825414
92TTN0.83547788
93ZAP700.83363667
94PKN20.81926245
95TRPM70.79811089
96* PRKD20.79217016
97PDGFRA0.73462644
98TAOK20.73139265
99EEF2K0.71172036
100PHKG10.70814712
101PHKG20.70814712
102PAK10.70413752
103PTK20.69537339
104CAMK10.69020237
105STK110.68605495
106MTOR0.66247973
107PDGFRB0.65861880
108IRAK40.63304434
109CDC42BPA0.62330324
110STK100.61778641
111MAP3K80.61331320
112MST1R0.60721092
113PRKCE0.59447319
114MAPK130.58121446
115UHMK10.56739101
116LIMK10.55749796
117TAOK10.55363228
118WNK10.54306655
119TBK10.53380929
120SGK10.53208117
121MARK20.51115850
122CAMK2G0.50518266
123BRAF0.49548446
124BCR0.49078794
125NEK20.48466663
126DAPK30.48347360
127MAPKAPK50.48320853
128DMPK0.46990110
129MAPKAPK20.46789358
130MET0.46577893
131RET0.46380696
132PRKCI0.46189883
133ROCK10.45623956
134FYN0.43401655
135MAP3K10.42466708
136PAK20.42386183
137GSK3A0.42324197
138PRKCH0.41876495
139GRK70.41400838
140MAPK110.40586039
141BRSK10.40362614
142CSNK1G20.40332180
143HIPK20.40232646
144NEK60.38462274
145RPS6KC10.37520154
146RPS6KL10.37520154
147DYRK1A0.37322833
148MUSK0.37075481
149AURKA0.36242339
150CSNK1E0.35543527
151IRAK20.35487502
152ADRBK10.35316095
153CSNK1A10.35120946
154PRKCZ0.34542983
155WNK40.34356595
156BUB10.34068568
157MAPK100.32715269
158AKT30.31384417
159NEK90.30824605
160MAPK70.29349862
161MELK0.29044767
162MAP2K60.26964542
163TGFBR10.26698683
164LRRK20.25333442

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.49501010
2Other glycan degradation_Homo sapiens_hsa005113.02970954
3Long-term potentiation_Homo sapiens_hsa047202.98963177
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.77255560
5Glutamatergic synapse_Homo sapiens_hsa047242.75876924
6Amphetamine addiction_Homo sapiens_hsa050312.71796904
7Circadian entrainment_Homo sapiens_hsa047132.59929264
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58357162
9Olfactory transduction_Homo sapiens_hsa047402.57517113
10Sulfur relay system_Homo sapiens_hsa041222.54195729
11Synaptic vesicle cycle_Homo sapiens_hsa047212.39193875
12Morphine addiction_Homo sapiens_hsa050322.31791631
13GABAergic synapse_Homo sapiens_hsa047272.27597155
14Salivary secretion_Homo sapiens_hsa049702.21885338
15Dopaminergic synapse_Homo sapiens_hsa047282.06219686
16Serotonergic synapse_Homo sapiens_hsa047261.94435836
17Long-term depression_Homo sapiens_hsa047301.91106383
18Oxytocin signaling pathway_Homo sapiens_hsa049211.89995235
19Gastric acid secretion_Homo sapiens_hsa049711.84860469
20Renin secretion_Homo sapiens_hsa049241.82952518
21Cholinergic synapse_Homo sapiens_hsa047251.78660149
22Taste transduction_Homo sapiens_hsa047421.75639678
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72238598
24Lysosome_Homo sapiens_hsa041421.70017766
25Cocaine addiction_Homo sapiens_hsa050301.68070321
26GnRH signaling pathway_Homo sapiens_hsa049121.65954367
27Calcium signaling pathway_Homo sapiens_hsa040201.65452603
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62602069
29Galactose metabolism_Homo sapiens_hsa000521.61793314
30Gap junction_Homo sapiens_hsa045401.59499565
31Axon guidance_Homo sapiens_hsa043601.59384508
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.58978554
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52945993
34Insulin secretion_Homo sapiens_hsa049111.49212642
35Small cell lung cancer_Homo sapiens_hsa052221.48186995
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45541365
37Shigellosis_Homo sapiens_hsa051311.45259347
38Collecting duct acid secretion_Homo sapiens_hsa049661.40628628
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39807384
40Glioma_Homo sapiens_hsa052141.39375988
41Fructose and mannose metabolism_Homo sapiens_hsa000511.37865285
42Cardiac muscle contraction_Homo sapiens_hsa042601.35472406
43Chronic myeloid leukemia_Homo sapiens_hsa052201.31976348
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27938793
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26081390
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23846183
47Melanogenesis_Homo sapiens_hsa049161.20310938
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.15814172
49Pentose phosphate pathway_Homo sapiens_hsa000301.14866072
50Dilated cardiomyopathy_Homo sapiens_hsa054141.14649826
51Notch signaling pathway_Homo sapiens_hsa043301.14525867
52Alzheimers disease_Homo sapiens_hsa050101.12874251
53cAMP signaling pathway_Homo sapiens_hsa040241.12576350
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09873777
55Salmonella infection_Homo sapiens_hsa051321.08656506
56Estrogen signaling pathway_Homo sapiens_hsa049151.08402856
57ErbB signaling pathway_Homo sapiens_hsa040121.08120215
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08111568
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06673084
60Phototransduction_Homo sapiens_hsa047441.06652047
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03842641
62VEGF signaling pathway_Homo sapiens_hsa043701.03377258
63Apoptosis_Homo sapiens_hsa042101.02442086
64Vibrio cholerae infection_Homo sapiens_hsa051101.01602110
65TNF signaling pathway_Homo sapiens_hsa046681.01450090
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99445064
67Oxidative phosphorylation_Homo sapiens_hsa001900.97923289
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.97859960
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96919565
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96352565
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.96169378
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95961504
73N-Glycan biosynthesis_Homo sapiens_hsa005100.95852175
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94522253
75Oocyte meiosis_Homo sapiens_hsa041140.91545502
76Rap1 signaling pathway_Homo sapiens_hsa040150.89832785
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86824532
78p53 signaling pathway_Homo sapiens_hsa041150.86707008
79Malaria_Homo sapiens_hsa051440.86283271
80Sulfur metabolism_Homo sapiens_hsa009200.85612237
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85156996
82MicroRNAs in cancer_Homo sapiens_hsa052060.83915699
83Pathways in cancer_Homo sapiens_hsa052000.83174599
84Choline metabolism in cancer_Homo sapiens_hsa052310.82349935
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81952392
86Pancreatic cancer_Homo sapiens_hsa052120.81849638
87Vitamin B6 metabolism_Homo sapiens_hsa007500.81132786
88Sphingolipid metabolism_Homo sapiens_hsa006000.80627660
89MAPK signaling pathway_Homo sapiens_hsa040100.80212572
90Toxoplasmosis_Homo sapiens_hsa051450.79711223
91Pertussis_Homo sapiens_hsa051330.78068817
92Protein digestion and absorption_Homo sapiens_hsa049740.77013801
93ECM-receptor interaction_Homo sapiens_hsa045120.76775519
94Parkinsons disease_Homo sapiens_hsa050120.76085209
95* Ras signaling pathway_Homo sapiens_hsa040140.75975974
96Pancreatic secretion_Homo sapiens_hsa049720.75208150
97Wnt signaling pathway_Homo sapiens_hsa043100.73800031
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72226898
99Thyroid cancer_Homo sapiens_hsa052160.72065468
100Hepatitis C_Homo sapiens_hsa051600.71689795
101Osteoclast differentiation_Homo sapiens_hsa043800.71556683
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71050636
103Bladder cancer_Homo sapiens_hsa052190.70822004
104Tight junction_Homo sapiens_hsa045300.69839588
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68185524
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67622603
107Focal adhesion_Homo sapiens_hsa045100.65878825
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65842689
109Acute myeloid leukemia_Homo sapiens_hsa052210.64565887
110Thyroid hormone synthesis_Homo sapiens_hsa049180.63887312
111Alcoholism_Homo sapiens_hsa050340.62824166
112Huntingtons disease_Homo sapiens_hsa050160.60229255
113Phagosome_Homo sapiens_hsa041450.59470770
114Renal cell carcinoma_Homo sapiens_hsa052110.58832007
115Dorso-ventral axis formation_Homo sapiens_hsa043200.57897949
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57279657
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.57128924
118Insulin signaling pathway_Homo sapiens_hsa049100.56889641
119African trypanosomiasis_Homo sapiens_hsa051430.55751028
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55560318
121mTOR signaling pathway_Homo sapiens_hsa041500.54866532
122Basal cell carcinoma_Homo sapiens_hsa052170.54669118
123Glutathione metabolism_Homo sapiens_hsa004800.54588740
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.52644364
125Proteoglycans in cancer_Homo sapiens_hsa052050.51205409
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50659880
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50474222
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49320361
129Melanoma_Homo sapiens_hsa052180.48619381
130Non-small cell lung cancer_Homo sapiens_hsa052230.48109821
131Prion diseases_Homo sapiens_hsa050200.47462533
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47088621
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46754080
134Endocytosis_Homo sapiens_hsa041440.44768600
135Hepatitis B_Homo sapiens_hsa051610.44659028
136Inositol phosphate metabolism_Homo sapiens_hsa005620.44242629
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.43154809
138Glucagon signaling pathway_Homo sapiens_hsa049220.43075774
139Insulin resistance_Homo sapiens_hsa049310.42871742
140Biosynthesis of amino acids_Homo sapiens_hsa012300.42315537
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42190695
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41441845
143HTLV-I infection_Homo sapiens_hsa051660.41354916
144Hippo signaling pathway_Homo sapiens_hsa043900.41281201
145Type II diabetes mellitus_Homo sapiens_hsa049300.40493173
146Amoebiasis_Homo sapiens_hsa051460.40057107
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39201424
148Hedgehog signaling pathway_Homo sapiens_hsa043400.39100621
149Pyrimidine metabolism_Homo sapiens_hsa002400.37231904
150Adherens junction_Homo sapiens_hsa045200.35075995
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33821454
152Rheumatoid arthritis_Homo sapiens_hsa053230.33386907
153Endometrial cancer_Homo sapiens_hsa052130.32854486
154Mineral absorption_Homo sapiens_hsa049780.32716825
155Ovarian steroidogenesis_Homo sapiens_hsa049130.32493370
156Platelet activation_Homo sapiens_hsa046110.31757802

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