RIMS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.47700096
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.38107905
3locomotory exploration behavior (GO:0035641)6.17582592
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.97934226
5vocalization behavior (GO:0071625)5.97737213
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.70006713
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.57522824
8synaptic vesicle exocytosis (GO:0016079)5.52549353
9glutamate secretion (GO:0014047)5.52481538
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.32527849
11regulation of glutamate receptor signaling pathway (GO:1900449)5.05882723
12layer formation in cerebral cortex (GO:0021819)4.98334239
13* regulation of synaptic vesicle exocytosis (GO:2000300)4.98042787
14protein localization to synapse (GO:0035418)4.93303099
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.77775576
16neurotransmitter secretion (GO:0007269)4.75852221
17exploration behavior (GO:0035640)4.74172246
18neuron cell-cell adhesion (GO:0007158)4.66531669
19gamma-aminobutyric acid transport (GO:0015812)4.61039083
20neuronal action potential propagation (GO:0019227)4.60352949
21neurotransmitter-gated ion channel clustering (GO:0072578)4.48310654
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.41785556
23dendritic spine morphogenesis (GO:0060997)4.40471507
24regulation of synapse structural plasticity (GO:0051823)4.39639192
25regulation of neuronal synaptic plasticity (GO:0048168)4.38922509
26synaptic transmission, glutamatergic (GO:0035249)4.37718069
27glutamate receptor signaling pathway (GO:0007215)4.37382148
28* regulation of synaptic vesicle transport (GO:1902803)4.33280575
29L-amino acid import (GO:0043092)4.16903342
30long-term memory (GO:0007616)4.07229883
31positive regulation of synapse maturation (GO:0090129)4.06248991
32proline transport (GO:0015824)4.05983651
33neuron-neuron synaptic transmission (GO:0007270)4.03441321
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02620627
35amino acid import (GO:0043090)3.97806580
36cellular potassium ion homeostasis (GO:0030007)3.96371607
37positive regulation of membrane potential (GO:0045838)3.93429688
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83593762
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.83158160
40postsynaptic membrane organization (GO:0001941)3.81693780
41activation of protein kinase A activity (GO:0034199)3.80868406
42cerebellar granule cell differentiation (GO:0021707)3.73446046
43sodium ion export (GO:0071436)3.72355331
44* neurotransmitter transport (GO:0006836)3.68622715
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.67479696
46cerebellar Purkinje cell differentiation (GO:0021702)3.64422188
47auditory behavior (GO:0031223)3.64077942
48regulation of postsynaptic membrane potential (GO:0060078)3.63657481
49regulation of dendritic spine morphogenesis (GO:0061001)3.61528047
50neuromuscular process controlling balance (GO:0050885)3.60365722
51dendrite morphogenesis (GO:0048813)3.59307965
52neuron recognition (GO:0008038)3.58523923
53cytoskeletal anchoring at plasma membrane (GO:0007016)3.54518432
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54080335
55glycine transport (GO:0015816)3.52318528
56synaptic vesicle endocytosis (GO:0048488)3.51909678
57* regulation of neurotransmitter secretion (GO:0046928)3.51815665
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.51343922
59transmission of nerve impulse (GO:0019226)3.49262445
60regulation of synaptic plasticity (GO:0048167)3.48488459
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.46325596
62regulation of neurotransmitter levels (GO:0001505)3.45285762
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.41191598
64negative regulation of dendrite morphogenesis (GO:0050774)3.40366709
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.37176229
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37161140
67response to pheromone (GO:0019236)3.35969069
68positive regulation of neurotransmitter secretion (GO:0001956)3.35582616
69response to auditory stimulus (GO:0010996)3.32078207
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29520371
71cell communication by electrical coupling (GO:0010644)3.29225967
72axonal fasciculation (GO:0007413)3.27863934
73presynaptic membrane assembly (GO:0097105)3.27666114
74synapse assembly (GO:0007416)3.26056097
75positive regulation of neurotransmitter transport (GO:0051590)3.25520496
76prepulse inhibition (GO:0060134)3.25227794
77* regulation of neurotransmitter transport (GO:0051588)3.24441873
78regulation of vesicle fusion (GO:0031338)3.23364146
79cell migration in hindbrain (GO:0021535)3.23214765
80positive regulation of dendritic spine development (GO:0060999)3.23017013
81long-term synaptic potentiation (GO:0060291)3.21955898
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.19733814
83regulation of synapse maturation (GO:0090128)3.18783287
84presynaptic membrane organization (GO:0097090)3.18689020
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17789757
86positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15889370
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.15543132
88regulation of ARF protein signal transduction (GO:0032012)3.14006316
89membrane depolarization (GO:0051899)3.14001334
90positive regulation of dendritic spine morphogenesis (GO:0061003)3.13548986
91regulation of dendritic spine development (GO:0060998)3.11857914
92membrane hyperpolarization (GO:0060081)3.11016323
93membrane depolarization during action potential (GO:0086010)3.09224625
94establishment of mitochondrion localization (GO:0051654)3.07784479
95potassium ion homeostasis (GO:0055075)3.06733137
96cerebellar Purkinje cell layer development (GO:0021680)3.05203528
97innervation (GO:0060384)3.04785782
98learning (GO:0007612)3.03844136
99dendritic spine organization (GO:0097061)3.03180670
100positive regulation of dendrite development (GO:1900006)3.01407920
101mechanosensory behavior (GO:0007638)3.01187918
102intraspecies interaction between organisms (GO:0051703)3.00055084
103social behavior (GO:0035176)3.00055084
104neuromuscular process controlling posture (GO:0050884)2.99312854
105mating behavior (GO:0007617)2.99032540
106* regulation of synaptic transmission (GO:0050804)2.98043135
107regulation of voltage-gated calcium channel activity (GO:1901385)2.98040409
108neuronal ion channel clustering (GO:0045161)2.97461648
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97431567
110neuromuscular process (GO:0050905)2.95849748
111negative regulation of microtubule polymerization (GO:0031115)2.90755772
112protein complex localization (GO:0031503)2.87109292
113neuromuscular synaptic transmission (GO:0007274)2.83121471
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.82868506
115mitochondrion transport along microtubule (GO:0047497)2.82868506
116potassium ion import (GO:0010107)2.78511340
117cellular sodium ion homeostasis (GO:0006883)2.76590093
118regulation of dendrite morphogenesis (GO:0048814)2.74936228
119adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.73926395
120cell communication involved in cardiac conduction (GO:0086065)2.72702786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.92875804
2GBX2_23144817_ChIP-Seq_PC3_Human3.29756193
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16116691
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15457185
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08852114
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82998467
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82998467
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.81404494
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69294422
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.62247421
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.59923277
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58376169
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56594998
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55942375
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55843210
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.55818106
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49566034
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.42888471
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35237017
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.30320302
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.30269277
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.29225998
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19571079
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18901380
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18455448
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11273424
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09444825
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06328091
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99826269
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96778477
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95774301
32AR_21572438_ChIP-Seq_LNCaP_Human1.86485022
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.69537081
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65275217
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57666025
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.53473066
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.48443022
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.41151253
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39893676
40* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37475927
41OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37305961
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34686563
43ZNF274_21170338_ChIP-Seq_K562_Hela1.33594376
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32845292
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31350849
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30136687
47LXR_22292898_ChIP-Seq_THP-1_Human1.29003414
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.28617998
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.27582948
50TAF15_26573619_Chip-Seq_HEK293_Human1.27243005
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26828008
52KDM2B_26808549_Chip-Seq_K562_Human1.26565868
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23868401
54* AR_19668381_ChIP-Seq_PC3_Human1.23747497
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22911683
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22349703
57* RING1B_27294783_Chip-Seq_NPCs_Mouse1.21930198
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20882756
59IGF1R_20145208_ChIP-Seq_DFB_Human1.18423410
60* SMC4_20622854_ChIP-Seq_HELA_Human1.17859353
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16741006
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16280536
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15639126
64* SMAD3_21741376_ChIP-Seq_EPCs_Human1.15503216
65AR_25329375_ChIP-Seq_VCAP_Human1.15489150
66STAT3_23295773_ChIP-Seq_U87_Human1.15160064
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14935025
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13953509
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13356671
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13273361
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12189834
72P300_19829295_ChIP-Seq_ESCs_Human1.11001845
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10925211
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10776281
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.10534093
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.09284600
77POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08946810
78RNF2_27304074_Chip-Seq_NSC_Mouse1.08406583
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07821438
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05981367
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05494882
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05333231
83KDM2B_26808549_Chip-Seq_DND41_Human1.04478275
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04413557
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03684619
86CREB1_26743006_Chip-Seq_LNCaP_Human1.03629377
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03472258
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03456344
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01629410
90* TCF4_23295773_ChIP-Seq_U87_Human1.01282925
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01111052
92* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00797031
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.00566328
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99460112
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98743961
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97901001
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.97828288
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97818722
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97529655
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96769224
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.95970172
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95586591
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.95181201
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.94938122
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94521426
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94521426
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94251443
108DPY_21335234_ChIP-Seq_ESCs_Mouse0.94036325
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93723707
110AHR_22903824_ChIP-Seq_MCF-7_Human0.93580138
111TET1_21451524_ChIP-Seq_MESCs_Mouse0.92383281
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91636147
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.91409143
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90036769
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88809062
116ISL1_27105846_Chip-Seq_CPCs_Mouse0.88370780
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88056909
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87582058
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.87484841
120* OCT4_19829295_ChIP-Seq_ESCs_Human0.87104871
121SOX3_22085726_ChIP-Seq_NPCs_Mouse0.86962421
122* RUNX2_22187159_ChIP-Seq_PCA_Human0.86855860
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85803750
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85438130
125P68_20966046_ChIP-Seq_HELA_Human0.85430546
126TP53_16413492_ChIP-PET_HCT116_Human0.85253308
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.84378271
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.83611380
129RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83596834
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82901773
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82576811
132* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82125354
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81966324
134* SMAD4_21741376_ChIP-Seq_EPCs_Human0.81153644
135CTCF_27219007_Chip-Seq_Bcells_Human0.81105691
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79633993
137POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79542550
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.79284456
139MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79024845
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78555674
141SMAD4_21741376_ChIP-Seq_ESCs_Human0.77229266
142KLF4_19829295_ChIP-Seq_ESCs_Human0.76117899
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76072538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.72659279
2MP0003635_abnormal_synaptic_transmissio4.32417572
3MP0003880_abnormal_central_pattern4.19129276
4MP0004270_analgesia3.74886232
5MP0009745_abnormal_behavioral_response3.44438626
6MP0002063_abnormal_learning/memory/cond3.44223463
7MP0009046_muscle_twitch3.40854949
8MP0002064_seizures3.18346543
9MP0005423_abnormal_somatic_nervous3.13939124
10MP0001968_abnormal_touch/_nociception2.88895217
11MP0002572_abnormal_emotion/affect_behav2.86845303
12MP0002734_abnormal_mechanical_nocicepti2.75587763
13MP0001486_abnormal_startle_reflex2.73572114
14MP0002272_abnormal_nervous_system2.59924016
15MP0002822_catalepsy2.36164759
16MP0001440_abnormal_grooming_behavior2.23242001
17MP0008569_lethality_at_weaning2.23119831
18MP0001501_abnormal_sleep_pattern2.19958441
19MP0009780_abnormal_chondrocyte_physiolo2.18390752
20MP0002736_abnormal_nociception_after2.09073138
21MP0002735_abnormal_chemical_nociception2.09050884
22MP0002067_abnormal_sensory_capabilities2.05219544
23MP0002733_abnormal_thermal_nociception2.02896302
24MP0001970_abnormal_pain_threshold1.95028809
25MP0000778_abnormal_nervous_system1.94784232
26MP0002184_abnormal_innervation1.94718203
27MP0002557_abnormal_social/conspecific_i1.94431361
28MP0000566_synostosis1.86493600
29MP0003329_amyloid_beta_deposits1.85839250
30MP0003123_paternal_imprinting1.84869489
31MP0002909_abnormal_adrenal_gland1.83518111
32MP0004811_abnormal_neuron_physiology1.82430612
33MP0004858_abnormal_nervous_system1.82338070
34MP0005386_behavior/neurological_phenoty1.77962053
35MP0004924_abnormal_behavior1.77962053
36MP0004885_abnormal_endolymph1.73799928
37MP0003879_abnormal_hair_cell1.71960575
38MP0000955_abnormal_spinal_cord1.62032175
39MP0003787_abnormal_imprinting1.49643500
40MP0002066_abnormal_motor_capabilities/c1.49449180
41MP0002882_abnormal_neuron_morphology1.47326282
42MP0000537_abnormal_urethra_morphology1.44284417
43MP0005646_abnormal_pituitary_gland1.38432999
44MP0003633_abnormal_nervous_system1.38092228
45MP0001984_abnormal_olfaction1.36155978
46MP0001346_abnormal_lacrimal_gland1.32273514
47MP0004142_abnormal_muscle_tone1.30591473
48MP0006276_abnormal_autonomic_nervous1.29691635
49MP0001502_abnormal_circadian_rhythm1.28125430
50MP0005645_abnormal_hypothalamus_physiol1.25692508
51MP0000569_abnormal_digit_pigmentation1.23612175
52MP0002152_abnormal_brain_morphology1.22731045
53MP0004742_abnormal_vestibular_system1.22039375
54MP0009672_abnormal_birth_weight1.21359946
55MP0003631_nervous_system_phenotype1.20592636
56MP0004145_abnormal_muscle_electrophysio1.13924996
57MP0002249_abnormal_larynx_morphology1.09341809
58MP0001188_hyperpigmentation1.03411438
59MP0008877_abnormal_DNA_methylation1.02614240
60MP0008872_abnormal_physiological_respon1.02583580
61MP0005551_abnormal_eye_electrophysiolog0.99149475
62MP0002229_neurodegeneration0.98205228
63MP0000579_abnormal_nail_morphology0.98048050
64MP0002069_abnormal_eating/drinking_beha0.95855024
65MP0003632_abnormal_nervous_system0.95667609
66MP0000751_myopathy0.95039260
67MP0001905_abnormal_dopamine_level0.91266768
68MP0003690_abnormal_glial_cell0.90039296
69MP0003119_abnormal_digestive_system0.89203875
70MP0001177_atelectasis0.89157997
71MP0003122_maternal_imprinting0.87566960
72MP0000631_abnormal_neuroendocrine_gland0.87436136
73MP0001529_abnormal_vocalization0.87416089
74MP0003634_abnormal_glial_cell0.85383835
75MP0000920_abnormal_myelination0.84392350
76MP0001963_abnormal_hearing_physiology0.83558935
77MP0002234_abnormal_pharynx_morphology0.82774422
78MP0002638_abnormal_pupillary_reflex0.81943706
79MP0008874_decreased_physiological_sensi0.81294154
80MP0000013_abnormal_adipose_tissue0.80997542
81MP0004085_abnormal_heartbeat0.80101093
82MP0002090_abnormal_vision0.78317310
83MP0000462_abnormal_digestive_system0.77618126
84MP0003283_abnormal_digestive_organ0.77564430
85MP0008961_abnormal_basal_metabolism0.77298409
86MP0003121_genomic_imprinting0.76563094
87MP0002752_abnormal_somatic_nervous0.76510625
88MP0000604_amyloidosis0.76229784
89MP0005535_abnormal_body_temperature0.75653278
90MP0003942_abnormal_urinary_system0.75445448
91MP0005394_taste/olfaction_phenotype0.75188890
92MP0005499_abnormal_olfactory_system0.75188890
93MP0010386_abnormal_urinary_bladder0.73819415
94MP0003137_abnormal_impulse_conducting0.72790295
95MP0002089_abnormal_postnatal_growth/wei0.72755819
96MP0002081_perinatal_lethality0.71180691
97MP0003075_altered_response_to0.71057594
98MP0005187_abnormal_penis_morphology0.69921135
99MP0001485_abnormal_pinna_reflex0.69897601
100MP0003938_abnormal_ear_development0.68860548
101MP0004233_abnormal_muscle_weight0.68239475
102MP0003861_abnormal_nervous_system0.66970805
103MP0005167_abnormal_blood-brain_barrier0.64635679
104MP0000534_abnormal_ureter_morphology0.64219315
105MP0003937_abnormal_limbs/digits/tail_de0.63998136
106MP0001943_abnormal_respiration0.63669379
107MP0005623_abnormal_meninges_morphology0.63403049
108MP0004215_abnormal_myocardial_fiber0.62205335
109MP0003315_abnormal_perineum_morphology0.62159487
110MP0003115_abnormal_respiratory_system0.61951213
111MP0001348_abnormal_lacrimal_gland0.60563097
112MP0010769_abnormal_survival0.60316435
113MP0004484_altered_response_of0.59959812
114MP0000049_abnormal_middle_ear0.59814604
115MP0005409_darkened_coat_color0.58429394
116MP0003705_abnormal_hypodermis_morpholog0.58095678
117MP0002102_abnormal_ear_morphology0.58019174
118MP0001664_abnormal_digestion0.57944048
119MP0002751_abnormal_autonomic_nervous0.57596736
120MP0010770_preweaning_lethality0.57526342
121MP0002082_postnatal_lethality0.57526342
122MP0010768_mortality/aging0.56732763
123MP0004043_abnormal_pH_regulation0.56476543
124MP0006072_abnormal_retinal_apoptosis0.56334264
125MP0001299_abnormal_eye_distance/0.53994814

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.90453770
2Myokymia (HP:0002411)6.88425260
3Visual hallucinations (HP:0002367)5.48133908
4Focal seizures (HP:0007359)5.41612308
5Progressive cerebellar ataxia (HP:0002073)4.84027178
6Epileptic encephalopathy (HP:0200134)4.83870456
7Action tremor (HP:0002345)4.51882053
8Febrile seizures (HP:0002373)4.32363888
9Atonic seizures (HP:0010819)4.11958902
10Broad-based gait (HP:0002136)3.95292188
11Absence seizures (HP:0002121)3.81072613
12Gaze-evoked nystagmus (HP:0000640)3.72294550
13Poor eye contact (HP:0000817)3.71425861
14Generalized tonic-clonic seizures (HP:0002069)3.69196212
15Ankle clonus (HP:0011448)3.68156163
16Mutism (HP:0002300)3.62803548
17Supranuclear gaze palsy (HP:0000605)3.60910372
18Dysdiadochokinesis (HP:0002075)3.56550846
19Dialeptic seizures (HP:0011146)3.38074011
20Depression (HP:0000716)3.30707769
21Impaired social interactions (HP:0000735)3.29097634
22Abnormal social behavior (HP:0012433)3.29097634
23Genetic anticipation (HP:0003743)3.28767406
24Urinary bladder sphincter dysfunction (HP:0002839)3.21902257
25Impaired vibration sensation in the lower limbs (HP:0002166)3.16288041
26Turricephaly (HP:0000262)3.12812287
27Papilledema (HP:0001085)3.07587933
28Hyperventilation (HP:0002883)3.06663416
29Dysmetria (HP:0001310)3.05748393
30Aplasia involving bones of the upper limbs (HP:0009823)3.03024541
31Aplasia of the phalanges of the hand (HP:0009802)3.03024541
32Aplasia involving bones of the extremities (HP:0009825)3.03024541
33Impaired smooth pursuit (HP:0007772)3.02563183
34Abnormal eating behavior (HP:0100738)3.00579181
35Abnormality of the lower motor neuron (HP:0002366)2.99499933
36Hemiparesis (HP:0001269)2.98483360
37Truncal ataxia (HP:0002078)2.93798067
38Scanning speech (HP:0002168)2.93602286
39Diplopia (HP:0000651)2.92670467
40Abnormality of binocular vision (HP:0011514)2.92670467
41Anxiety (HP:0000739)2.88931744
42Postural instability (HP:0002172)2.87497791
43Hemiplegia (HP:0002301)2.86584675
44Drooling (HP:0002307)2.85822322
45Excessive salivation (HP:0003781)2.85822322
46Intention tremor (HP:0002080)2.83193272
47Urinary urgency (HP:0000012)2.76733901
48Amyotrophic lateral sclerosis (HP:0007354)2.73712151
49Dysmetric saccades (HP:0000641)2.69708857
50Abnormality of ocular smooth pursuit (HP:0000617)2.68813430
51Spastic gait (HP:0002064)2.67011970
52Progressive inability to walk (HP:0002505)2.65226065
53Torticollis (HP:0000473)2.63440290
54Abnormality of the corticospinal tract (HP:0002492)2.61991832
55Amblyopia (HP:0000646)2.60551078
56Stereotypic behavior (HP:0000733)2.55881853
57Neurofibrillary tangles (HP:0002185)2.55493691
58Limb dystonia (HP:0002451)2.49033388
59Tetraplegia (HP:0002445)2.46221052
60Epileptiform EEG discharges (HP:0011182)2.44275403
61Megalencephaly (HP:0001355)2.43270686
62Fetal akinesia sequence (HP:0001989)2.42922915
63Focal dystonia (HP:0004373)2.42867454
64EEG with generalized epileptiform discharges (HP:0011198)2.41451540
65Cerebral inclusion bodies (HP:0100314)2.38984992
66Agitation (HP:0000713)2.38410276
67Status epilepticus (HP:0002133)2.38176951
68Absent speech (HP:0001344)2.37446250
69Bradykinesia (HP:0002067)2.37239414
70Ventricular fibrillation (HP:0001663)2.36793782
71Hypsarrhythmia (HP:0002521)2.32934731
72Polyphagia (HP:0002591)2.26520279
73Inappropriate behavior (HP:0000719)2.26239156
74Pointed chin (HP:0000307)2.25624140
75Pheochromocytoma (HP:0002666)2.25335323
76Bronchomalacia (HP:0002780)2.22786347
77Impaired vibratory sensation (HP:0002495)2.22708914
78Insomnia (HP:0100785)2.22264631
79Inability to walk (HP:0002540)2.20401680
80Gonadal dysgenesis (HP:0000133)2.19798210
81Hyperacusis (HP:0010780)2.19042149
82Annular pancreas (HP:0001734)2.18796498
83Obstructive sleep apnea (HP:0002870)2.18362913
84Sleep apnea (HP:0010535)2.17620026
85Termporal pattern (HP:0011008)2.16944670
86Insidious onset (HP:0003587)2.16944670
87Lower limb muscle weakness (HP:0007340)2.11038553
88Craniofacial dystonia (HP:0012179)2.10399484
89Abnormality of the phalanges of the hallux (HP:0010057)2.09104646
90Generalized myoclonic seizures (HP:0002123)2.04808554
91Neuronal loss in central nervous system (HP:0002529)2.03635937
92Overriding aorta (HP:0002623)2.02988760
93Transposition of the great arteries (HP:0001669)2.02891197
94Abnormal connection of the cardiac segments (HP:0011545)2.02891197
95Abnormal ventriculo-arterial connection (HP:0011563)2.02891197
96Clonus (HP:0002169)2.02781245
97Gait ataxia (HP:0002066)2.02252931
98Aqueductal stenosis (HP:0002410)1.99684325
99Morphological abnormality of the pyramidal tract (HP:0002062)1.92670838
100Cutaneous finger syndactyly (HP:0010554)1.92277269
101Cutaneous syndactyly (HP:0012725)1.92071140
102Blue irides (HP:0000635)1.90938868
103Akinesia (HP:0002304)1.89744646
104Abnormality of saccadic eye movements (HP:0000570)1.87584227
105Incomplete penetrance (HP:0003829)1.87072624
106Germ cell neoplasia (HP:0100728)1.86760843
107Abnormality of salivation (HP:0100755)1.85620320
108Apathy (HP:0000741)1.85425890
109Shallow orbits (HP:0000586)1.85404044
110Neuroendocrine neoplasm (HP:0100634)1.84510019
111Spastic tetraparesis (HP:0001285)1.84211643
112Cerebral hypomyelination (HP:0006808)1.84007035
113Intellectual disability, profound (HP:0002187)1.83414152
114Bundle branch block (HP:0011710)1.82206501
115Relative macrocephaly (HP:0004482)1.79747798
116Diminished motivation (HP:0000745)1.79191737
117Hypoventilation (HP:0002791)1.76207414
118Lower limb asymmetry (HP:0100559)1.76029685
119Lower limb amyotrophy (HP:0007210)1.74620204
120Psychosis (HP:0000709)1.73197628
121Postural tremor (HP:0002174)1.72634624
122Protruding tongue (HP:0010808)1.69165254
123Resting tremor (HP:0002322)1.68463341
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.67870968
125Peripheral hypomyelination (HP:0007182)1.67811112
126Elfin facies (HP:0004428)1.67598793
127Choanal stenosis (HP:0000452)1.67173050
128Abnormality of cochlea (HP:0000375)1.64432372
129Split foot (HP:0001839)1.64281140
130Abnormality of the middle phalanges of the toes (HP:0010183)1.61501473
131Hammertoe (HP:0001765)1.59454646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.40100008
2MAP3K93.91255323
3NTRK33.75257694
4EPHA43.51244643
5DAPK23.12515492
6MAP3K43.10475141
7MINK12.70945889
8MAP2K72.54674102
9PAK62.42871248
10NTRK22.33178080
11PRKD32.20520793
12EEF2K2.19448610
13CAMKK12.08525452
14CASK1.92903983
15MAP2K41.89781747
16NTRK11.65435158
17KSR21.59113782
18CDK51.56735683
19MAPK131.56677237
20PRPF4B1.54035682
21SIK21.53735975
22DAPK11.52823087
23CDK191.49675159
24MAP3K121.40839495
25PHKG11.40498408
26PHKG21.40498408
27STK381.38353334
28PNCK1.36949401
29KSR11.36265079
30CAMKK21.33951162
31PLK21.33788289
32GRK51.29797882
33RIPK41.27909551
34PRKCG1.26162911
35TNIK1.26114768
36TYRO31.26096955
37LATS21.25734944
38PINK11.15643234
39RIPK11.15209660
40CAMK1D1.14212372
41UHMK11.10939651
42ALK1.08091709
43TAOK11.07711353
44STK111.05619055
45FGFR21.02930905
46FES1.02272745
47TRIB31.01735196
48CAMK11.01208841
49CDK150.97785762
50CDK180.97215639
51STK240.94860460
52PRKCH0.90431228
53CDK140.90127809
54SGK4940.89733545
55SGK2230.89733545
56DYRK1A0.87316591
57MAP3K20.86460772
58CDK11A0.85983056
59WNK10.84755984
60SMG10.82974103
61CAMK2A0.82255758
62CSNK1G20.82166123
63RET0.78919984
64MARK20.74941853
65OXSR10.74658932
66SGK20.73303744
67ARAF0.71317479
68CAMK1G0.69300698
69SGK10.69055782
70PAK30.68604484
71SGK30.67079860
72MAP3K100.66616883
73LMTK20.63891979
74PDK10.62194031
75BRAF0.60557032
76CDK120.59507334
77BRD40.57060328
78CCNB10.56406056
79PRKCZ0.56265729
80CDC42BPA0.56153084
81PDPK10.55582545
82TAOK20.54674507
83TSSK60.54253362
84CAMK2B0.53139958
85RPS6KA30.53134975
86SCYL20.52956380
87ERBB30.51464684
88TTK0.50930548
89FYN0.50581186
90CAMK40.50391121
91MAPK120.49399250
92PKN10.49022827
93RPS6KB10.47270828
94MAP3K130.47224268
95PRKCE0.45527441
96RAF10.45230321
97DAPK30.43705802
98BMPR20.43272826
99TNK20.42633462
100CDC70.41521036
101DYRK20.41105665
102MAPK100.38720437
103NEK60.38703029
104PTK2B0.38194547
105RPS6KA20.37685508
106GSK3B0.37680321
107CHEK20.37657442
108CSNK1G30.37195456
109BRSK10.36760120
110WNK30.36485394
111CSNK1E0.36184913
112CAMK2G0.34178269
113CSNK1A1L0.33985408
114MAP2K60.33983843
115PDGFRA0.33980923
116CSNK1D0.33966325
117NEK10.33357259
118CSNK1G10.32963628
119PRKCB0.32026724
120PRKDC0.31926605
121MAP3K70.31725914
122AKT20.31637203
123MAP3K10.30107675
124PRKG10.28515608
125ICK0.27667676

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.72350466
2Synaptic vesicle cycle_Homo sapiens_hsa047213.28369656
3GABAergic synapse_Homo sapiens_hsa047272.75760056
4Circadian entrainment_Homo sapiens_hsa047132.73854063
5Glutamatergic synapse_Homo sapiens_hsa047242.72936721
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69647618
7Olfactory transduction_Homo sapiens_hsa047402.64704800
8Long-term potentiation_Homo sapiens_hsa047202.56339931
9Morphine addiction_Homo sapiens_hsa050322.53889034
10Amphetamine addiction_Homo sapiens_hsa050312.27717570
11Salivary secretion_Homo sapiens_hsa049702.19438465
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18834440
13Vitamin B6 metabolism_Homo sapiens_hsa007502.16031132
14Dopaminergic synapse_Homo sapiens_hsa047282.11878583
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.06072061
16Insulin secretion_Homo sapiens_hsa049111.94450316
17Cholinergic synapse_Homo sapiens_hsa047251.92156514
18Gastric acid secretion_Homo sapiens_hsa049711.89539033
19Long-term depression_Homo sapiens_hsa047301.81579504
20Taste transduction_Homo sapiens_hsa047421.72327025
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68497796
22Renin secretion_Homo sapiens_hsa049241.67818605
23Oxytocin signaling pathway_Homo sapiens_hsa049211.66701098
24Serotonergic synapse_Homo sapiens_hsa047261.53466792
25Cocaine addiction_Homo sapiens_hsa050301.51039153
26Calcium signaling pathway_Homo sapiens_hsa040201.50309674
27GnRH signaling pathway_Homo sapiens_hsa049121.47277483
28Gap junction_Homo sapiens_hsa045401.40622383
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36913994
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31277179
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29452906
32cAMP signaling pathway_Homo sapiens_hsa040241.29416597
33Type II diabetes mellitus_Homo sapiens_hsa049301.29295475
34Axon guidance_Homo sapiens_hsa043601.23537772
35Estrogen signaling pathway_Homo sapiens_hsa049151.22912400
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20413940
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19302368
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11249625
39Glioma_Homo sapiens_hsa052141.10186039
40Nitrogen metabolism_Homo sapiens_hsa009101.06562462
41Collecting duct acid secretion_Homo sapiens_hsa049661.05562357
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05114844
43ErbB signaling pathway_Homo sapiens_hsa040121.04969810
44Melanogenesis_Homo sapiens_hsa049161.02734556
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95551941
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94009879
47Arginine biosynthesis_Homo sapiens_hsa002200.93913338
48Hippo signaling pathway_Homo sapiens_hsa043900.91801027
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.91596705
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.88658759
51Pancreatic secretion_Homo sapiens_hsa049720.88453080
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87303702
53Oocyte meiosis_Homo sapiens_hsa041140.86003074
54Dorso-ventral axis formation_Homo sapiens_hsa043200.84658533
55Hedgehog signaling pathway_Homo sapiens_hsa043400.81325661
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80944601
57AMPK signaling pathway_Homo sapiens_hsa041520.79596070
58Phototransduction_Homo sapiens_hsa047440.79217707
59Thyroid hormone synthesis_Homo sapiens_hsa049180.76155044
60Cardiac muscle contraction_Homo sapiens_hsa042600.75089120
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73273895
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73013477
63Choline metabolism in cancer_Homo sapiens_hsa052310.71988140
64MAPK signaling pathway_Homo sapiens_hsa040100.70576786
65Ovarian steroidogenesis_Homo sapiens_hsa049130.70210084
66Dilated cardiomyopathy_Homo sapiens_hsa054140.69924170
67Tight junction_Homo sapiens_hsa045300.69062478
68mRNA surveillance pathway_Homo sapiens_hsa030150.68292418
69Vibrio cholerae infection_Homo sapiens_hsa051100.67543482
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67414832
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66636949
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.65533850
73Endometrial cancer_Homo sapiens_hsa052130.62619279
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61434544
75Arginine and proline metabolism_Homo sapiens_hsa003300.58918773
76Ras signaling pathway_Homo sapiens_hsa040140.58566524
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58193767
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58165159
79Bile secretion_Homo sapiens_hsa049760.57581951
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.57152767
81Biosynthesis of amino acids_Homo sapiens_hsa012300.56744966
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56408252
83VEGF signaling pathway_Homo sapiens_hsa043700.55880886
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.54332069
85Rap1 signaling pathway_Homo sapiens_hsa040150.54111024
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52709145
87Alcoholism_Homo sapiens_hsa050340.51431171
88Renal cell carcinoma_Homo sapiens_hsa052110.50304897
89Glucagon signaling pathway_Homo sapiens_hsa049220.50044293
90mTOR signaling pathway_Homo sapiens_hsa041500.49692875
91Endocytosis_Homo sapiens_hsa041440.49207513
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48391334
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46519317
94Circadian rhythm_Homo sapiens_hsa047100.46516140
95Wnt signaling pathway_Homo sapiens_hsa043100.46062617
96Inositol phosphate metabolism_Homo sapiens_hsa005620.44866288
97Type I diabetes mellitus_Homo sapiens_hsa049400.43545451
98Basal cell carcinoma_Homo sapiens_hsa052170.43487947
99Insulin signaling pathway_Homo sapiens_hsa049100.43468897
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42737380
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42239212
102Adherens junction_Homo sapiens_hsa045200.42033843
103Non-small cell lung cancer_Homo sapiens_hsa052230.41461606
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41275730
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40398336
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38557082
107Chemokine signaling pathway_Homo sapiens_hsa040620.38106041
108Fatty acid biosynthesis_Homo sapiens_hsa000610.37156373
109Prion diseases_Homo sapiens_hsa050200.35790377
110Colorectal cancer_Homo sapiens_hsa052100.35062504
111Lysine degradation_Homo sapiens_hsa003100.34842467
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32369453
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31353449
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30689176
115Prolactin signaling pathway_Homo sapiens_hsa049170.25183661
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24003977

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