RHPN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.85235364
2piRNA metabolic process (GO:0034587)5.58684753
3regulation of meiosis (GO:0040020)5.49855484
4female gamete generation (GO:0007292)5.37060568
5regulation of female gonad development (GO:2000194)5.27386887
6metaphase plate congression (GO:0051310)4.97660158
7protein K6-linked ubiquitination (GO:0085020)4.85157572
8negative regulation of meiosis (GO:0045835)4.80794154
9mitotic chromosome condensation (GO:0007076)4.80265007
10axonemal dynein complex assembly (GO:0070286)4.70830029
11DNA damage induced protein phosphorylation (GO:0006975)4.67168768
12regulation of meiosis I (GO:0060631)4.61237218
13desmosome organization (GO:0002934)4.54699026
14negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.49906880
15establishment of chromosome localization (GO:0051303)4.45498749
16intestinal epithelial cell development (GO:0060576)4.40033380
17regulation of meiotic cell cycle (GO:0051445)4.40031070
18meiotic cell cycle (GO:0051321)4.39436169
19DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.27440229
20oocyte maturation (GO:0001556)4.24480691
21meiotic chromosome segregation (GO:0045132)4.21908415
22regulation of sister chromatid cohesion (GO:0007063)4.18725896
23DNA damage response, signal transduction resulting in transcription (GO:0042772)4.17536691
24type B pancreatic cell development (GO:0003323)4.13668169
25negative regulation of hormone metabolic process (GO:0032351)4.06797595
26negative regulation of hormone biosynthetic process (GO:0032353)4.06797595
27attachment of spindle microtubules to kinetochore (GO:0008608)4.04571617
28maturation of 5.8S rRNA (GO:0000460)4.03709806
29histone H2A monoubiquitination (GO:0035518)4.01675115
30notochord development (GO:0030903)3.98791810
31DNA methylation involved in gamete generation (GO:0043046)3.95774641
32negative regulation of meiotic cell cycle (GO:0051447)3.90191576
33bundle of His cell to Purkinje myocyte communication (GO:0086069)3.89646243
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89436144
35male meiosis (GO:0007140)3.86707175
36regulation of histone H3-K27 methylation (GO:0061085)3.82848342
37negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.78977532
38negative regulation of DNA-templated transcription, elongation (GO:0032785)3.78977532
39kinetochore assembly (GO:0051382)3.78852358
40primary alcohol catabolic process (GO:0034310)3.76634614
41regulation of spindle organization (GO:0090224)3.72575181
42CENP-A containing nucleosome assembly (GO:0034080)3.70806934
43mitotic sister chromatid segregation (GO:0000070)3.69850869
44chromatin remodeling at centromere (GO:0031055)3.66296194
45histone H2A ubiquitination (GO:0033522)3.62964999
46regulation of RIG-I signaling pathway (GO:0039535)3.61808755
47DNA replication checkpoint (GO:0000076)3.61462530
48columnar/cuboidal epithelial cell development (GO:0002066)3.61183401
49female gonad development (GO:0008585)3.59326117
50regulation of exit from mitosis (GO:0007096)3.58297721
51glycerophospholipid catabolic process (GO:0046475)3.57614045
52protein localization to kinetochore (GO:0034501)3.57085421
53cilium movement (GO:0003341)3.53103915
54regulation of DNA methylation (GO:0044030)3.48509119
55protein localization to chromosome, centromeric region (GO:0071459)3.48293190
56regulation of retinoic acid receptor signaling pathway (GO:0048385)3.44476695
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.44256930
58vitamin transmembrane transport (GO:0035461)3.42987312
59cilium or flagellum-dependent cell motility (GO:0001539)3.42169308
60regulation of mitotic spindle organization (GO:0060236)3.40276589
61inner cell mass cell proliferation (GO:0001833)3.36587089
62regulation of glucocorticoid metabolic process (GO:0031943)3.36404538
63kinetochore organization (GO:0051383)3.36348013
64negative regulation of smooth muscle cell differentiation (GO:0051151)3.35696578
65DNA replication-independent nucleosome assembly (GO:0006336)3.35025861
66DNA replication-independent nucleosome organization (GO:0034724)3.35025861
67spindle checkpoint (GO:0031577)3.32608226
68L-serine metabolic process (GO:0006563)3.32366613
69chromosome segregation (GO:0007059)3.29439084
70establishment of apical/basal cell polarity (GO:0035089)3.26797704
71regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26297681
72monoubiquitinated protein deubiquitination (GO:0035520)3.24547110
73histone exchange (GO:0043486)3.24200970
74calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.23543004
75protein localization to chromosome (GO:0034502)3.22591599
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.22466321
77positive regulation of Cdc42 GTPase activity (GO:0043089)3.21835202
78diterpenoid biosynthetic process (GO:0016102)3.20196227
79regulation of chromosome segregation (GO:0051983)3.19672918
80sphingosine metabolic process (GO:0006670)3.16007154
81COPI coating of Golgi vesicle (GO:0048205)3.15037142
82Golgi transport vesicle coating (GO:0048200)3.15037142
83lung epithelium development (GO:0060428)3.14922293
84rRNA methylation (GO:0031167)3.13766309
85regulation of steroid hormone secretion (GO:2000831)3.13620074
86glandular epithelial cell development (GO:0002068)3.13442796
87rRNA modification (GO:0000154)3.12108475
88paraxial mesoderm development (GO:0048339)3.10286629
89diol metabolic process (GO:0034311)3.08530383
90tight junction assembly (GO:0070830)3.08519400
91negative regulation of keratinocyte proliferation (GO:0010839)3.08120883
92epithelial cilium movement (GO:0003351)3.07138769
93male meiosis I (GO:0007141)3.06653321
94mitotic nuclear envelope disassembly (GO:0007077)3.06541793
95positive regulation of chromosome segregation (GO:0051984)3.04760271
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03111468
97DNA alkylation (GO:0006305)3.02256534
98DNA methylation (GO:0006306)3.02256534
99motile cilium assembly (GO:0044458)3.00757778
100negative regulation of cell division (GO:0051782)2.99942485
101mitotic spindle checkpoint (GO:0071174)2.98209907
102negative regulation of nuclear division (GO:0051784)2.96073043
103regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.95572455
104positive regulation of mitotic sister chromatid separation (GO:1901970)2.93597828
105positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93597828
106positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93597828
107negative regulation of chromosome segregation (GO:0051985)2.93242367
108snRNA transcription (GO:0009301)2.93186645
109regulation of hippo signaling (GO:0035330)2.92910868
110regulation of keratinocyte proliferation (GO:0010837)2.91793942
111regulation of transforming growth factor beta2 production (GO:0032909)2.90980114
112proline biosynthetic process (GO:0006561)2.90332371
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88250759
114negative regulation of sister chromatid segregation (GO:0033046)2.88250759
115negative regulation of mitotic sister chromatid separation (GO:2000816)2.88250759
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88250759
117meiotic cell cycle process (GO:1903046)2.86990466
118positive regulation of megakaryocyte differentiation (GO:0045654)2.86979410
119cysteine metabolic process (GO:0006534)2.85008688
120meiosis I (GO:0007127)2.84928789
121biotin metabolic process (GO:0006768)2.84915729
122establishment of monopolar cell polarity (GO:0061162)2.82345121
123establishment or maintenance of monopolar cell polarity (GO:0061339)2.82345121
124terpenoid biosynthetic process (GO:0016114)2.79790946
125serine family amino acid biosynthetic process (GO:0009070)2.73448408
126gap junction assembly (GO:0016264)2.66747931
127asymmetric protein localization (GO:0008105)2.62537772
128branching involved in salivary gland morphogenesis (GO:0060445)2.61010929
1294-hydroxyproline metabolic process (GO:0019471)2.59701483
130polyketide metabolic process (GO:0030638)2.59101479
131doxorubicin metabolic process (GO:0044598)2.59101479
132daunorubicin metabolic process (GO:0044597)2.59101479
133ethanol metabolic process (GO:0006067)2.53675253
134nucleotide-sugar biosynthetic process (GO:0009226)2.51875065
135proline metabolic process (GO:0006560)2.51587816
136apical protein localization (GO:0045176)2.49030013
137cellular glucuronidation (GO:0052695)2.47092823
138intestinal absorption (GO:0050892)2.45600078
139uronic acid metabolic process (GO:0006063)2.45318666
140glucuronate metabolic process (GO:0019585)2.45318666
141epithelial cell-cell adhesion (GO:0090136)2.42514518
142protein autoprocessing (GO:0016540)2.36391332
143nephron tubule formation (GO:0072079)2.35710673
144establishment or maintenance of apical/basal cell polarity (GO:0035088)2.30683270
145establishment or maintenance of bipolar cell polarity (GO:0061245)2.30683270
146regulation of cilium movement (GO:0003352)2.30305616
147aminoglycoside antibiotic metabolic process (GO:0030647)2.28604180
148flavonoid metabolic process (GO:0009812)2.28028663
149auditory receptor cell differentiation (GO:0042491)2.27483985
150very-low-density lipoprotein particle assembly (GO:0034379)2.26341757
151intestinal cholesterol absorption (GO:0030299)2.23236833
152positive regulation of hormone metabolic process (GO:0032352)2.23036051
153serine family amino acid metabolic process (GO:0009069)2.21804112
154cardiac right ventricle morphogenesis (GO:0003215)2.20374368
155cellular aldehyde metabolic process (GO:0006081)2.20062131
156pyrimidine-containing compound transmembrane transport (GO:0072531)2.19595962
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.19573030
158L-phenylalanine metabolic process (GO:0006558)2.19573030
159cell-cell junction assembly (GO:0007043)2.19440493
160UDP-N-acetylglucosamine metabolic process (GO:0006047)2.19346593
161hippo signaling (GO:0035329)2.17267948
162regulation of cholesterol biosynthetic process (GO:0045540)2.16031208
163glucose 6-phosphate metabolic process (GO:0051156)2.16022553
164O-glycan processing (GO:0016266)2.13237071
165axoneme assembly (GO:0035082)2.12251622
166lung lobe morphogenesis (GO:0060463)2.12205343
167glutamine family amino acid biosynthetic process (GO:0009084)2.11933276
168lung-associated mesenchyme development (GO:0060484)2.07658676
169regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.06836616
170regulation of cardioblast differentiation (GO:0051890)2.05482575
171GDP-mannose metabolic process (GO:0019673)2.03743084
172establishment of planar polarity (GO:0001736)2.02354904
173establishment of tissue polarity (GO:0007164)2.02354904
174ear development (GO:0043583)2.01246489
175ethanol oxidation (GO:0006069)2.01140298
176embryonic foregut morphogenesis (GO:0048617)2.01098153
177maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.00535279
178establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.00276694
179branching involved in mammary gland duct morphogenesis (GO:0060444)1.99162515
180epithelial tube branching involved in lung morphogenesis (GO:0060441)1.98681526
181retinoic acid metabolic process (GO:0042573)1.98565807
182glomerular epithelial cell development (GO:0072310)1.97915628
183left/right pattern formation (GO:0060972)1.97807947
184histone H2B ubiquitination (GO:0033523)1.96535726
185regulation of bile acid biosynthetic process (GO:0070857)1.96239876
186regulation of branching involved in ureteric bud morphogenesis (GO:0090189)1.95894466
187amino-acid betaine metabolic process (GO:0006577)1.93507699
188COPII vesicle coating (GO:0048208)1.92654489
189regulation of cell-cell adhesion mediated by cadherin (GO:2000047)1.92604228
190multicellular organismal water homeostasis (GO:0050891)1.90785218
191regulation of translational fidelity (GO:0006450)1.89951664
192negative regulation of T cell differentiation in thymus (GO:0033085)1.89761052
193primary alcohol metabolic process (GO:0034308)1.89386443
194polarized epithelial cell differentiation (GO:0030859)1.89312134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.54592153
2E2F7_22180533_ChIP-Seq_HELA_Human4.71645062
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.60745517
4KAP1_22055183_ChIP-Seq_ESCs_Mouse3.50180508
5AR_21909140_ChIP-Seq_LNCAP_Human3.26178844
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.99086017
7ZNF263_19887448_ChIP-Seq_K562_Human2.99083503
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.87909177
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.83558892
10* CDX2_20551321_ChIP-Seq_CACO-2_Human2.72345331
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.58476723
12* ESR2_21235772_ChIP-Seq_MCF-7_Human2.53893786
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51867328
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.50279110
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44053012
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39433116
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35285269
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.30903569
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23273976
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.19772750
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.92389521
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.89869780
23* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86810677
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85565913
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85066752
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83599274
27* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81479992
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74440388
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.74306249
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.69325708
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69193730
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.66901691
33* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66389398
34* E2F1_21310950_ChIP-Seq_MCF-7_Human1.64662696
35MYC_18940864_ChIP-ChIP_HL60_Human1.63568689
36* GATA3_24758297_ChIP-Seq_MCF-7_Human1.60736859
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56398698
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53813343
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51429705
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51255133
41* RUNX1_27514584_Chip-Seq_MCF-7_Human1.50356918
42* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48689041
43RUNX1_26923725_Chip-Seq_HPCs_Mouse1.48429727
44IGF1R_20145208_ChIP-Seq_DFB_Human1.47945109
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46951776
46AHR_22903824_ChIP-Seq_MCF-7_Human1.46201617
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44423542
48* FOXO3_23340844_ChIP-Seq_DLD1_Human1.42486497
49NANOG_21062744_ChIP-ChIP_HESCs_Human1.39240927
50SOX2_20726797_ChIP-Seq_SW620_Human1.36105598
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36057220
52CHD1_26751641_Chip-Seq_LNCaP_Human1.35302340
53CDX2_22108803_ChIP-Seq_LS180_Human1.35154207
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34610802
55* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33805245
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33575064
57* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32715403
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32296416
59* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.31267047
60DCP1A_22483619_ChIP-Seq_HELA_Human1.30752814
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28723444
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28713107
63STAT1_17558387_ChIP-Seq_HELA_Human1.28668472
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28531952
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27453154
66FUS_26573619_Chip-Seq_HEK293_Human1.27305721
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.26929837
68LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26776576
69RACK7_27058665_Chip-Seq_MCF-7_Human1.26632941
70EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25840385
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23541018
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23355677
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22985607
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.22195417
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21736709
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21346533
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.21045726
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21039140
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20969059
80GATA6_25053715_ChIP-Seq_YYC3_Human1.20777750
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20724913
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19449850
83ATF3_27146783_Chip-Seq_COLON_Human1.19364014
84* KAP1_27257070_Chip-Seq_ESCs_Mouse1.19118569
85CLOCK_20551151_ChIP-Seq_293T_Human1.18918499
86XRN2_22483619_ChIP-Seq_HELA_Human1.18812066
87LXR_22158963_ChIP-Seq_LIVER_Mouse1.18418616
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18207755
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.17877793
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17429645
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17423692
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17257172
93* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15950550
94FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15480319
95ERG_20517297_ChIP-Seq_VCAP_Human1.14940003
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13930369
97* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12536837
98PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12293469
99TTF2_22483619_ChIP-Seq_HELA_Human1.11573493
100GATA4_25053715_ChIP-Seq_YYC3_Human1.11390756
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11064718
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10945977
103KDM5A_27292631_Chip-Seq_BREAST_Human1.10555969
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10107069
105EST1_17652178_ChIP-ChIP_JURKAT_Human1.08932277
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08630857
107* KLF5_25053715_ChIP-Seq_YYC3_Human1.08586768
108* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08441991
109GABP_19822575_ChIP-Seq_HepG2_Human1.07405138
110* SOX17_20123909_ChIP-Seq_XEN_Mouse1.06825785
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06773020
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05071229
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04560946
114ELF5_23300383_ChIP-Seq_T47D_Human1.04353636
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04013342
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03701337
117NFYA_21822215_ChIP-Seq_K562_Human1.03375582
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02865578
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00498268
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99936325
121* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99369659
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.99179144
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98512215
124MYC_18555785_ChIP-Seq_MESCs_Mouse0.98319787
125* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98050880
126PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97893286
127* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97864784
128STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97287846
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.97222109
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97162736
131SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96594324
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.96551594
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96215951
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96009505
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95416944
136SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95001784
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95001784
138ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94761582
139HNFA_21074721_ChIP-Seq_CACO-2_Human0.92788053
140RNF2_27304074_Chip-Seq_NSC_Mouse0.92746060
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.92414646
142KLF4_18555785_Chip-Seq_ESCs_Mouse0.92238865
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92212964
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.92163675
145ZFX_18555785_Chip-Seq_ESCs_Mouse0.91663859
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91651863
147CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90655586
148POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89950174
149GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89739497
150* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89070070
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88870842
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88820486
153VDR_22108803_ChIP-Seq_LS180_Human0.88533760
154POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87966443
155* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87293441
156SOX2_18555785_Chip-Seq_ESCs_Mouse0.86796802
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.86327435
158MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85871512
159NMYC_18555785_Chip-Seq_ESCs_Mouse0.85674511
160POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85371103
161FOXA1_25552417_ChIP-Seq_VCAP_Human0.84925955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.10907940
2MP0003693_abnormal_embryo_hatching4.58099369
3MP0005451_abnormal_body_composition4.20234828
4MP0002653_abnormal_ependyma_morphology3.55712233
5MP0004264_abnormal_extraembryonic_tissu3.30160547
6MP0000537_abnormal_urethra_morphology2.87128539
7MP0002102_abnormal_ear_morphology2.80288877
8MP0003111_abnormal_nucleus_morphology2.76069837
9MP0004957_abnormal_blastocyst_morpholog2.73624470
10MP0006292_abnormal_olfactory_placode2.69793377
11MP0008877_abnormal_DNA_methylation2.68387608
12MP0010094_abnormal_chromosome_stability2.61442343
13MP0003077_abnormal_cell_cycle2.55778126
14MP0003646_muscle_fatigue2.52563777
15MP0003136_yellow_coat_color2.39840769
16MP0005408_hypopigmentation2.36762517
17MP0005395_other_phenotype2.35349915
18MP0001119_abnormal_female_reproductive2.34253315
19MP0000462_abnormal_digestive_system2.17877039
20MP0010678_abnormal_skin_adnexa2.14555004
21MP0003699_abnormal_female_reproductive2.13330046
22MP0000383_abnormal_hair_follicle2.04445435
23MP0000678_abnormal_parathyroid_gland1.97531457
24MP0000566_synostosis1.95461338
25MP0003941_abnormal_skin_development1.87505225
26MP0000653_abnormal_sex_gland1.84395966
27MP0002877_abnormal_melanocyte_morpholog1.83878990
28MP0003890_abnormal_embryonic-extraembry1.82887739
29MP0001929_abnormal_gametogenesis1.82814787
30MP0002249_abnormal_larynx_morphology1.81030730
31MP0003123_paternal_imprinting1.76760335
32MP0002210_abnormal_sex_determination1.68958194
33MP0003937_abnormal_limbs/digits/tail_de1.65786031
34MP0000579_abnormal_nail_morphology1.64826516
35MP0004133_heterotaxia1.63190924
36MP0003878_abnormal_ear_physiology1.62178225
37MP0005377_hearing/vestibular/ear_phenot1.62178225
38MP0003787_abnormal_imprinting1.58181641
39MP0000613_abnormal_salivary_gland1.54446860
40MP0008058_abnormal_DNA_repair1.54201123
41MP0008932_abnormal_embryonic_tissue1.53186871
42MP0005310_abnormal_salivary_gland1.52912727
43MP0004019_abnormal_vitamin_homeostasis1.45120929
44MP0008004_abnormal_stomach_pH1.40552359
45MP0005360_urolithiasis1.39696111
46MP0010386_abnormal_urinary_bladder1.39553813
47MP0005076_abnormal_cell_differentiation1.37499889
48MP0000647_abnormal_sebaceous_gland1.36895605
49MP0001293_anophthalmia1.35080084
50MP0008057_abnormal_DNA_replication1.34003981
51MP0002085_abnormal_embryonic_tissue1.33869992
52MP0002796_impaired_skin_barrier1.33612221
53MP0008007_abnormal_cellular_replicative1.33031499
54MP0009780_abnormal_chondrocyte_physiolo1.32702717
55MP0002697_abnormal_eye_size1.31271385
56MP0001145_abnormal_male_reproductive1.31127946
57MP0010352_gastrointestinal_tract_polyps1.31081935
58MP0000490_abnormal_crypts_of1.30028602
59MP0004185_abnormal_adipocyte_glucose1.27667371
60MP0010234_abnormal_vibrissa_follicle1.26636918
61MP0003315_abnormal_perineum_morphology1.24840578
62MP0001346_abnormal_lacrimal_gland1.23321763
63MP0003121_genomic_imprinting1.23288097
64MP0005501_abnormal_skin_physiology1.22896224
65MP0001730_embryonic_growth_arrest1.22353147
66MP0000762_abnormal_tongue_morphology1.20914344
67MP0002938_white_spotting1.20561107
68MP0000350_abnormal_cell_proliferation1.19708300
69MP0004858_abnormal_nervous_system1.18811476
70MP0005380_embryogenesis_phenotype1.13806861
71MP0001672_abnormal_embryogenesis/_devel1.13806861
72MP0005379_endocrine/exocrine_gland_phen1.11870927
73MP0001697_abnormal_embryo_size1.11192528
74MP0002084_abnormal_developmental_patter1.08966628
75MP0003942_abnormal_urinary_system1.08956768
76MP0005365_abnormal_bile_salt1.06051611
77MP0004043_abnormal_pH_regulation1.06018790
78MP0001944_abnormal_pancreas_morphology1.05938146
79MP0000627_abnormal_mammary_gland1.05480800
80MP0002161_abnormal_fertility/fecundity1.05069002
81MP0002693_abnormal_pancreas_physiology1.04594238
82MP0002139_abnormal_hepatobiliary_system1.03570387
83MP0005248_abnormal_Harderian_gland1.03322362
84MP0009053_abnormal_anal_canal1.03087980
85MP0001849_ear_inflammation1.02679642
86MP0000377_abnormal_hair_follicle1.01427053
87MP0005220_abnormal_exocrine_pancreas1.01414616
88MP0003119_abnormal_digestive_system0.99975942
89MP0008789_abnormal_olfactory_epithelium0.99342358
90MP0005646_abnormal_pituitary_gland0.99331577
91MP0004233_abnormal_muscle_weight0.99046024
92MP0000467_abnormal_esophagus_morphology0.97502389
93MP0001915_intracranial_hemorrhage0.96847240
94MP0009379_abnormal_foot_pigmentation0.95246810
95MP0002111_abnormal_tail_morphology0.93677675
96MP0004272_abnormal_basement_membrane0.93618896
97MP0005389_reproductive_system_phenotype0.93047473
98MP0002282_abnormal_trachea_morphology0.92917592
99MP0003938_abnormal_ear_development0.92794720
100MP0000639_abnormal_adrenal_gland0.90808221
101MP0001664_abnormal_digestion0.89421600
102MP0001919_abnormal_reproductive_system0.88527729
103MP0002092_abnormal_eye_morphology0.87984482
104MP0005187_abnormal_penis_morphology0.86890224
105MP0002163_abnormal_gland_morphology0.85194349
106MP0002277_abnormal_respiratory_mucosa0.85169654
107MP0001485_abnormal_pinna_reflex0.85004355
108MP0006072_abnormal_retinal_apoptosis0.83546350
109MP0001881_abnormal_mammary_gland0.83439246
110MP0003943_abnormal_hepatobiliary_system0.82650829
111MP0003861_abnormal_nervous_system0.82163829
112MP0001666_abnormal_nutrient_absorption0.81206431
113MP0005083_abnormal_biliary_tract0.80973705
114MP0003755_abnormal_palate_morphology0.80211754
115MP0000477_abnormal_intestine_morphology0.79923119
116MP0010030_abnormal_orbit_morphology0.79788069
117MP0002080_prenatal_lethality0.79168700
118MP0005257_abnormal_intraocular_pressure0.78928320
119MP0005332_abnormal_amino_acid0.78653623
120MP0005394_taste/olfaction_phenotype0.78604926
121MP0005499_abnormal_olfactory_system0.78604926
122MP0003868_abnormal_feces_composition0.78231161
123MP0004782_abnormal_surfactant_physiolog0.77869439
124MP0003252_abnormal_bile_duct0.77720923
125MP0009672_abnormal_birth_weight0.75706729
126MP0002089_abnormal_postnatal_growth/wei0.75334077
127MP0003984_embryonic_growth_retardation0.75208227
128MP0005647_abnormal_sex_gland0.74761934
129MP0001216_abnormal_epidermal_layer0.74221204
130MP0000427_abnormal_hair_cycle0.73532612
131MP0000432_abnormal_head_morphology0.72595961
132MP0002638_abnormal_pupillary_reflex0.72178648
133MP0000631_abnormal_neuroendocrine_gland0.72176995
134MP0002086_abnormal_extraembryonic_tissu0.71966042
135MP0002088_abnormal_embryonic_growth/wei0.71186489
136MP0005085_abnormal_gallbladder_physiolo0.70784405
137MP0002160_abnormal_reproductive_system0.70549697
138MP0002019_abnormal_tumor_incidence0.70533605
139MP0002233_abnormal_nose_morphology0.70418340
140MP0002098_abnormal_vibrissa_morphology0.69437166
141MP0000470_abnormal_stomach_morphology0.69311139
142MP0003786_premature_aging0.69253683
143MP0003011_delayed_dark_adaptation0.68810165
144MP0003936_abnormal_reproductive_system0.67423306
145MP0002177_abnormal_outer_ear0.67325465
146MP0003698_abnormal_male_reproductive0.65775041
147MP0008875_abnormal_xenobiotic_pharmacok0.65745890
148MP0002116_abnormal_craniofacial_bone0.64439967
149MP0001286_abnormal_eye_development0.63476468

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)5.79324278
2Chromsome breakage (HP:0040012)4.99669478
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.88552419
4Birth length less than 3rd percentile (HP:0003561)4.32535893
5Papillary thyroid carcinoma (HP:0002895)4.19265436
6Abnormal respiratory motile cilium physiology (HP:0012261)4.19147514
7Rhinitis (HP:0012384)4.07160744
8Breast hypoplasia (HP:0003187)3.92170882
9Abnormal respiratory motile cilium morphology (HP:0005938)3.86697378
10Abnormal respiratory epithelium morphology (HP:0012253)3.86697378
11Shawl scrotum (HP:0000049)3.82634874
12Abnormal ciliary motility (HP:0012262)3.82493557
13Flat capital femoral epiphysis (HP:0003370)3.48329693
14Patellar aplasia (HP:0006443)3.46161786
15Insulin-resistant diabetes mellitus (HP:0000831)3.39214935
16Adrenal hypoplasia (HP:0000835)3.33312439
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.31569911
18Absent/shortened dynein arms (HP:0200106)3.31569911
19Chronic bronchitis (HP:0004469)3.25196148
20Aplasia/Hypoplasia of the patella (HP:0006498)3.24994759
21Facial hemangioma (HP:0000329)3.17660166
22Secondary amenorrhea (HP:0000869)3.10914756
23Lip pit (HP:0100267)3.10186395
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96536935
25Capillary hemangiomas (HP:0005306)2.95111636
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.92724657
27Hypoplasia of the fovea (HP:0007750)2.92724657
28Hypergonadotropic hypogonadism (HP:0000815)2.92697808
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.90199457
30Abnormality of the preputium (HP:0100587)2.88827928
31Hyperglycemia (HP:0003074)2.86327742
32Abnormality of chromosome stability (HP:0003220)2.83785899
33Abnormality of the fingertips (HP:0001211)2.83437626
34Right ventricular cardiomyopathy (HP:0011663)2.82912589
35Abnormality of the labia minora (HP:0012880)2.78147390
36Abnormality of the fovea (HP:0000493)2.73803148
37Flat acetabular roof (HP:0003180)2.73339435
38Abnormality of the nasal septum (HP:0000419)2.70628277
39Premature ovarian failure (HP:0008209)2.67360630
40Breast aplasia (HP:0100783)2.67358452
41Meckel diverticulum (HP:0002245)2.65199247
42Aplasia/Hypoplasia of the breasts (HP:0010311)2.62023215
43Bronchiectasis (HP:0002110)2.56977677
44Ectopic kidney (HP:0000086)2.50043027
45Hyperactive renin-angiotensin system (HP:0000841)2.49785066
46Abnormality of the ileum (HP:0001549)2.49342083
47Absent radius (HP:0003974)2.46897880
48Facial cleft (HP:0002006)2.43961980
49Impulsivity (HP:0100710)2.39436483
50Thyroid carcinoma (HP:0002890)2.38752592
51Rib fusion (HP:0000902)2.38581919
52Duodenal stenosis (HP:0100867)2.36324216
53Small intestinal stenosis (HP:0012848)2.36324216
54Absent eyebrow (HP:0002223)2.34584604
55Absent forearm bone (HP:0003953)2.32705312
56Aplasia involving forearm bones (HP:0009822)2.32705312
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.31291937
58Bifid scrotum (HP:0000048)2.30246137
59Aplasia/hypoplasia of the uterus (HP:0008684)2.29649105
60Overlapping toe (HP:0001845)2.27020883
61Hyperglycinuria (HP:0003108)2.25760931
62Villous atrophy (HP:0011473)2.25258837
63Abnormality of small intestinal villus morphology (HP:0011472)2.25258837
64Intrahepatic cholestasis (HP:0001406)2.25041881
65Carpal bone hypoplasia (HP:0001498)2.23329399
66Pulmonary fibrosis (HP:0002206)2.18150223
67Sandal gap (HP:0001852)2.17001420
68Bronchomalacia (HP:0002780)2.16626916
69Hypoplasia of the uterus (HP:0000013)2.15939049
70Occipital encephalocele (HP:0002085)2.15665088
71Cortical dysplasia (HP:0002539)2.13865304
72Pancreatic fibrosis (HP:0100732)2.12566235
73Pterygium (HP:0001059)2.12043461
74Bicornuate uterus (HP:0000813)2.11781706
75Conjugated hyperbilirubinemia (HP:0002908)2.11506923
76Acute myeloid leukemia (HP:0004808)2.11300503
77Aplasia/Hypoplasia of the sternum (HP:0006714)2.09697718
78Short thumb (HP:0009778)2.08059370
79Vascular calcification (HP:0004934)2.06465818
80Congenital sensorineural hearing impairment (HP:0008527)2.05248223
81Pili torti (HP:0003777)2.03624683
82Infertility (HP:0000789)2.02988565
83Abnormality of the duodenum (HP:0002246)2.02913761
84Aplasia/Hypoplasia involving the musculature (HP:0001460)1.99662651
85Supernumerary spleens (HP:0009799)1.99435801
86Abnormality of glycolysis (HP:0004366)1.99017473
87Abnormal biliary tract morphology (HP:0012440)1.98580003
88Pancreatic cysts (HP:0001737)1.97667160
89Abnormality of glycine metabolism (HP:0010895)1.97648682
90Abnormality of serine family amino acid metabolism (HP:0010894)1.97648682
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96767431
92Abnormality of lateral ventricle (HP:0030047)1.96208898
93Proximal tubulopathy (HP:0000114)1.96181733
94Aplastic anemia (HP:0001915)1.96092815
95Prostate neoplasm (HP:0100787)1.95402508
96Oral leukoplakia (HP:0002745)1.94134470
97Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.93897221
98Vertebral hypoplasia (HP:0008417)1.93897221
99Clubbing of toes (HP:0100760)1.93494187
100Nephroblastoma (Wilms tumor) (HP:0002667)1.93339897
101Bilateral microphthalmos (HP:0007633)1.93001797
102Sloping forehead (HP:0000340)1.92950324
103Bifid tongue (HP:0010297)1.91838174
104Myelodysplasia (HP:0002863)1.91035696
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.90946688
106Oligodactyly (HP:0012165)1.90404009
107Oligodactyly (hands) (HP:0001180)1.90346609
108Sparse lateral eyebrow (HP:0005338)1.89245193
109Abnormal lung lobation (HP:0002101)1.88923629
110Abnormality of the femoral head (HP:0003368)1.88918248
111Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88826813
112Abnormality of the proximal phalanges of the hand (HP:0009834)1.88403367
113Cystic hygroma (HP:0000476)1.86943663
114Gout (HP:0001997)1.86254544
115Abnormality of the phalanges of the hallux (HP:0010057)1.84261841
116Hydroxyprolinuria (HP:0003080)1.82114081
117Abnormality of proline metabolism (HP:0010907)1.82114081
118Primary amenorrhea (HP:0000786)1.80312506
119Enlarged epiphyses (HP:0010580)1.79535622
120Focal segmental glomerulosclerosis (HP:0000097)1.79501128
121Concave nail (HP:0001598)1.78956875
122Abnormality of the dental root (HP:0006486)1.78439383
123Taurodontia (HP:0000679)1.78439383
124Abnormality of permanent molar morphology (HP:0011071)1.78439383
125Insulin resistance (HP:0000855)1.78302220
126Unilateral renal agenesis (HP:0000122)1.78166396
127Fibular aplasia (HP:0002990)1.77183126
128Anomalous pulmonary venous return (HP:0010772)1.76736906
129Septate vagina (HP:0001153)1.76079812
130Rhabdomyosarcoma (HP:0002859)1.75906302
131Abnormality of the distal phalanges of the toes (HP:0010182)1.75610338
132Myelomeningocele (HP:0002475)1.75240686
133Embryonal renal neoplasm (HP:0011794)1.74730278
134Abnormality of the carotid arteries (HP:0005344)1.74268821
135True hermaphroditism (HP:0010459)1.72935139
136Abnormal pancreas size (HP:0012094)1.72490031
137Hyperphosphatemia (HP:0002905)1.72393044
138Sex reversal (HP:0012245)1.71457893
139Abnormal sex determination (HP:0012244)1.71457893
140Abnormality of the epiphysis of the femoral head (HP:0010574)1.71351443
141Hypobetalipoproteinemia (HP:0003563)1.71140709
142Aplasia/Hypoplasia of the macula (HP:0008059)1.71140317
143Horseshoe kidney (HP:0000085)1.70747410
144Anophthalmia (HP:0000528)1.70563650
145Malnutrition (HP:0004395)1.70385386
146Amniotic constriction ring (HP:0009775)1.68696550
147Abnormality of placental membranes (HP:0011409)1.68696550
148Short nail (HP:0001799)1.66369304
149Hypoplastic iliac wings (HP:0002866)1.65874736
150Microretrognathia (HP:0000308)1.65336958
151Anal stenosis (HP:0002025)1.64732100
152Vaginal atresia (HP:0000148)1.64726317
153Glomerulosclerosis (HP:0000096)1.64320225
154Abnormal tarsal ossification (HP:0008369)1.64149515
155Hyperglycinemia (HP:0002154)1.63074910
15611 pairs of ribs (HP:0000878)1.62130836
157Partial duplication of thumb phalanx (HP:0009944)1.60827210
158Median cleft lip (HP:0000161)1.60544322
159Genital tract atresia (HP:0001827)1.59684289
160Missing ribs (HP:0000921)1.59616615
161Deep venous thrombosis (HP:0002625)1.58823711
162Tubular atrophy (HP:0000092)1.57267430
163Absent eyelashes (HP:0000561)1.57084694
164Abnormality of carpal bone ossification (HP:0006257)1.56975088
165Abnormality of the dental pulp (HP:0006479)1.56902918
166Amelogenesis imperfecta (HP:0000705)1.56812375
167Curly hair (HP:0002212)1.56265771
168Cystic liver disease (HP:0006706)1.56237430
169Prolonged partial thromboplastin time (HP:0003645)1.54608125
170Late onset (HP:0003584)1.54304365
171Preaxial hand polydactyly (HP:0001177)1.54012119
172Tubulointerstitial nephritis (HP:0001970)1.52766268
173Cardiovascular calcification (HP:0011915)1.51958114
174Midline defect of the nose (HP:0004122)1.51559047
175Choanal stenosis (HP:0000452)1.51360299
176Abnormality of molar (HP:0011077)1.50761236
177Abnormality of molar morphology (HP:0011070)1.50761236
178Renal tubular acidosis (HP:0001947)1.48240836
179Duplication of thumb phalanx (HP:0009942)1.46248779
180Increased serum pyruvate (HP:0003542)1.45690632
181Abnormality of the lacrimal duct (HP:0011481)1.45457425
182Esophageal atresia (HP:0002032)1.45097136
183Hemivertebrae (HP:0002937)1.44798407
184Hyperammonemia (HP:0001987)1.44140990
185Abnormal hair laboratory examination (HP:0003328)1.42464696
186Abnormal hand bone ossification (HP:0010660)1.42079525
187Poor coordination (HP:0002370)1.41961781
188Postaxial foot polydactyly (HP:0001830)1.41258659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.49910005
2TAOK34.46083962
3STK38L4.41206415
4MST1R3.89737451
5PLK43.86238700
6LATS23.83961946
7TTK3.23143940
8STK393.20967220
9MAP3K63.05724126
10MST42.89587814
11ERBB42.85179285
12BMPR22.76977851
13TRIB32.75270875
14MOS2.68606758
15MET2.61899111
16KSR22.46250560
17BRAF2.35945425
18LMTK22.31951499
19CDC72.30411249
20MUSK2.00768769
21CDK81.94155834
22TAOK11.91693922
23STK31.84340654
24TSSK61.67357341
25CHEK21.66170484
26MELK1.59779106
27FRK1.46820372
28MAP3K91.44115208
29ICK1.39783652
30MAP3K131.37125053
31PLK11.36599825
32EEF2K1.33927310
33RAF11.30763664
34PRKD31.30185462
35CDK91.29035854
36NEK11.28272145
37NEK21.26582391
38DYRK21.26042299
39EPHB11.25090486
40MAPKAPK31.24587618
41SMG11.24043845
42NUAK11.21039098
43NEK61.20611820
44OXSR11.19222544
45ARAF1.18221893
46BCR1.17443281
47PIK3CA1.17324896
48IRAK31.16331812
49EPHA21.15167635
50STK101.10363005
51ACVR1B1.05846050
52STK241.04532288
53PAK41.04505913
54STK381.04270960
55FER1.04032503
56MAP3K121.03559695
57PKN21.02845753
58BUB11.02821031
59AURKB1.01378789
60ABL21.01160786
61PTK21.00835802
62FGFR40.96215715
63EPHB20.95223572
64TRIM280.94645849
65FGFR10.94347231
66CDK120.93210031
67NLK0.93000489
68PRKD20.92119819
69MAP3K80.91831729
70VRK20.87069984
71ERBB20.83657992
72PINK10.83242532
73CAMK1D0.82072689
74SRPK10.79753572
75VRK10.79145675
76PNCK0.75790553
77CDK70.75297783
78EIF2AK30.71794802
79SIK10.71230683
80BRSK20.70565209
81AURKA0.70362821
82FGFR20.68748023
83CASK0.68143502
84KSR10.68138695
85PRKCI0.67842308
86MAPKAPK50.66529909
87PRKAA20.63963153
88ATM0.63447990
89CAMK1G0.63396839
90PLK30.63011571
91PRKAA10.61871671
92HIPK20.59915760
93ILK0.57193883
94CSNK1G10.56805273
95CDK30.55738974
96RPS6KB20.55676476
97AKT30.55431771
98CHEK10.55347591
99MAP3K20.54849770
100MTOR0.54573038
101INSRR0.54565459
102PTK60.54303589
103BMPR1B0.51528768
104TLK10.50374265
105MAP2K20.49902101
106WEE10.49319089
107AKT20.46908970
108MAPK130.46319295
109TRPM70.45881635
110GRK10.45534151
111PASK0.45226431
112MAP3K10.44751905
113PAK60.43564565
114NME20.41422293
115DMPK0.40961705
116EIF2AK10.40454037
117LRRK20.40323181
118MAP3K50.39172506
119PBK0.35498865
120BMX0.35383743
121ATR0.33871584
122EIF2AK20.33795855
123CDK20.33326281
124NEK90.33064910
125MAPK150.32434947
126SCYL20.31625521
127MARK20.30940768
128ZAK0.30705916
129TNIK0.29994678
130PRKG20.29553120
131WNK40.29394979
132ABL10.29384877
133MAPK110.28843631
134TAF10.27533228
135CDK10.27328687
136NME10.26287263
137CDK40.25720260
138CHUK0.25176311
139MKNK20.23733748
140PDK20.23730512
141RET0.23442629
142MAP2K70.23318787
143SGK20.22789785
144RPS6KA40.22680889
145EPHA30.22331267
146MAP3K40.21594431
147MAP2K10.21559053
148BRSK10.18619359
149CSNK1E0.17918668

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.94672464
2Cell cycle_Homo sapiens_hsa041103.42878899
3RNA degradation_Homo sapiens_hsa030183.28198385
4Basal transcription factors_Homo sapiens_hsa030223.18894856
5RNA polymerase_Homo sapiens_hsa030202.97947789
6Fanconi anemia pathway_Homo sapiens_hsa034602.61618760
7Linoleic acid metabolism_Homo sapiens_hsa005912.57490921
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.54173903
9Vitamin B6 metabolism_Homo sapiens_hsa007502.50978630
10Homologous recombination_Homo sapiens_hsa034402.45353276
11Ovarian steroidogenesis_Homo sapiens_hsa049132.44354534
12Circadian rhythm_Homo sapiens_hsa047102.40691521
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.33976332
14Folate biosynthesis_Homo sapiens_hsa007902.00123375
15Ether lipid metabolism_Homo sapiens_hsa005651.95110402
16p53 signaling pathway_Homo sapiens_hsa041151.90871405
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86471265
18Mismatch repair_Homo sapiens_hsa034301.77185638
19RNA transport_Homo sapiens_hsa030131.76252633
20Base excision repair_Homo sapiens_hsa034101.75127743
21Protein export_Homo sapiens_hsa030601.73485929
22Phenylalanine metabolism_Homo sapiens_hsa003601.72029189
23DNA replication_Homo sapiens_hsa030301.71623688
24TGF-beta signaling pathway_Homo sapiens_hsa043501.65065747
25Pyrimidine metabolism_Homo sapiens_hsa002401.64441029
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.58176805
27Biosynthesis of amino acids_Homo sapiens_hsa012301.53395077
28Non-homologous end-joining_Homo sapiens_hsa034501.49615232
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49587131
30Fructose and mannose metabolism_Homo sapiens_hsa000511.47408892
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46020353
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38717214
33Nucleotide excision repair_Homo sapiens_hsa034201.30900396
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30039528
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26659503
36Oocyte meiosis_Homo sapiens_hsa041141.26577611
37Pyruvate metabolism_Homo sapiens_hsa006201.26157755
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25423681
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24073173
40Sulfur metabolism_Homo sapiens_hsa009201.24061371
41Arachidonic acid metabolism_Homo sapiens_hsa005901.23578272
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21514539
43Nitrogen metabolism_Homo sapiens_hsa009101.19839820
44Fatty acid degradation_Homo sapiens_hsa000711.19618284
45Fatty acid biosynthesis_Homo sapiens_hsa000611.18394844
46Pancreatic cancer_Homo sapiens_hsa052121.17063093
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16972495
48Sulfur relay system_Homo sapiens_hsa041221.16897392
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16527272
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15408889
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.14856557
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14769102
53One carbon pool by folate_Homo sapiens_hsa006701.14639018
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.12223473
55Propanoate metabolism_Homo sapiens_hsa006401.11337071
56Thyroid cancer_Homo sapiens_hsa052161.10794757
57Dorso-ventral axis formation_Homo sapiens_hsa043201.10439707
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10097496
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09470474
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09124539
61Purine metabolism_Homo sapiens_hsa002301.06887856
62Fatty acid metabolism_Homo sapiens_hsa012121.06873100
63Prolactin signaling pathway_Homo sapiens_hsa049171.05331349
64Carbon metabolism_Homo sapiens_hsa012001.04920724
65Bile secretion_Homo sapiens_hsa049760.98038911
66MicroRNAs in cancer_Homo sapiens_hsa052060.96561564
67mRNA surveillance pathway_Homo sapiens_hsa030150.96128261
68Other glycan degradation_Homo sapiens_hsa005110.95820160
69Glutathione metabolism_Homo sapiens_hsa004800.95563306
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95535118
71Sphingolipid metabolism_Homo sapiens_hsa006000.94101464
72N-Glycan biosynthesis_Homo sapiens_hsa005100.93787359
73Hippo signaling pathway_Homo sapiens_hsa043900.91617915
74Histidine metabolism_Homo sapiens_hsa003400.91407597
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89235181
76Peroxisome_Homo sapiens_hsa041460.88904446
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88699452
78Proteasome_Homo sapiens_hsa030500.87786170
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87017185
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.85061909
81Retinol metabolism_Homo sapiens_hsa008300.82976402
82Adherens junction_Homo sapiens_hsa045200.82550990
83Vitamin digestion and absorption_Homo sapiens_hsa049770.81144452
84Steroid biosynthesis_Homo sapiens_hsa001000.77152153
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74942977
86Arginine and proline metabolism_Homo sapiens_hsa003300.74496833
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74330811
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.73972097
89Butanoate metabolism_Homo sapiens_hsa006500.73026859
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71585604
91Bladder cancer_Homo sapiens_hsa052190.70203155
92Fat digestion and absorption_Homo sapiens_hsa049750.69648678
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66631469
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65014527
95ABC transporters_Homo sapiens_hsa020100.64617631
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.61929247
97Notch signaling pathway_Homo sapiens_hsa043300.60144315
98Selenocompound metabolism_Homo sapiens_hsa004500.59476637
99Spliceosome_Homo sapiens_hsa030400.58799892
100Fatty acid elongation_Homo sapiens_hsa000620.58395492
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58295823
102Mineral absorption_Homo sapiens_hsa049780.58277741
103PPAR signaling pathway_Homo sapiens_hsa033200.58177759
104Huntingtons disease_Homo sapiens_hsa050160.57615145
105Vibrio cholerae infection_Homo sapiens_hsa051100.57027888
106Lysine degradation_Homo sapiens_hsa003100.56867049
107Choline metabolism in cancer_Homo sapiens_hsa052310.56571595
108FoxO signaling pathway_Homo sapiens_hsa040680.53944231
109Prostate cancer_Homo sapiens_hsa052150.53082955
110Colorectal cancer_Homo sapiens_hsa052100.51455483
111Herpes simplex infection_Homo sapiens_hsa051680.49460509
112Galactose metabolism_Homo sapiens_hsa000520.49336079
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49209077
114Endometrial cancer_Homo sapiens_hsa052130.47510754
115Regulation of autophagy_Homo sapiens_hsa041400.45706477
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42745629
117Tight junction_Homo sapiens_hsa045300.41890983
118Small cell lung cancer_Homo sapiens_hsa052220.41650864
119beta-Alanine metabolism_Homo sapiens_hsa004100.40254676
120GnRH signaling pathway_Homo sapiens_hsa049120.39783751
121Tryptophan metabolism_Homo sapiens_hsa003800.38863552
122Chemical carcinogenesis_Homo sapiens_hsa052040.37786674
123Pentose phosphate pathway_Homo sapiens_hsa000300.37584570
124Metabolic pathways_Homo sapiens_hsa011000.36262231
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34064572
126Hedgehog signaling pathway_Homo sapiens_hsa043400.32977320
127Renal cell carcinoma_Homo sapiens_hsa052110.32591939
128Basal cell carcinoma_Homo sapiens_hsa052170.31875822
129Tyrosine metabolism_Homo sapiens_hsa003500.31717410
130Caffeine metabolism_Homo sapiens_hsa002320.30263972
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.28747548
132Starch and sucrose metabolism_Homo sapiens_hsa005000.28673903
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27152030
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26403730
135Arginine biosynthesis_Homo sapiens_hsa002200.25960385
136Inositol phosphate metabolism_Homo sapiens_hsa005620.25246533
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24876912
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24250702
139Wnt signaling pathway_Homo sapiens_hsa043100.21856883
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19918770

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