RHOXF2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.47483184
2mitochondrial respiratory chain complex I assembly (GO:0032981)5.02713749
3NADH dehydrogenase complex assembly (GO:0010257)5.02713749
4mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.02713749
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.49973262
6ATP synthesis coupled proton transport (GO:0015986)4.49973262
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.46093083
8protein complex biogenesis (GO:0070271)4.40541184
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.34106584
10negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.27509419
11rRNA modification (GO:0000154)4.26604024
12chaperone-mediated protein transport (GO:0072321)4.24431883
13mitochondrial respiratory chain complex assembly (GO:0033108)4.22925715
14synapsis (GO:0007129)4.07300161
15water-soluble vitamin biosynthetic process (GO:0042364)4.03271166
16behavioral response to nicotine (GO:0035095)4.02337277
17maturation of 5.8S rRNA (GO:0000460)3.85447850
18proteasome assembly (GO:0043248)3.83049232
19male meiosis I (GO:0007141)3.73533938
20protein deneddylation (GO:0000338)3.72225918
21respiratory electron transport chain (GO:0022904)3.69123396
22electron transport chain (GO:0022900)3.67199351
23cullin deneddylation (GO:0010388)3.64838459
24rRNA methylation (GO:0031167)3.63617853
25piRNA metabolic process (GO:0034587)3.58905251
26protein-cofactor linkage (GO:0018065)3.53014661
27regulation of retinoic acid receptor signaling pathway (GO:0048385)3.52957679
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.47049093
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40010791
30regulation of meiosis I (GO:0060631)3.39548615
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39488577
32response to pheromone (GO:0019236)3.37156488
33DNA methylation involved in gamete generation (GO:0043046)3.34880050
34resolution of meiotic recombination intermediates (GO:0000712)3.34117025
35transcription from mitochondrial promoter (GO:0006390)3.33648076
36pseudouridine synthesis (GO:0001522)3.31076576
37rRNA catabolic process (GO:0016075)3.25062410
38male meiosis (GO:0007140)3.21912076
39maturation of SSU-rRNA (GO:0030490)3.19844187
40indolalkylamine metabolic process (GO:0006586)3.09581732
41tryptophan catabolic process (GO:0006569)3.07046689
42indole-containing compound catabolic process (GO:0042436)3.07046689
43indolalkylamine catabolic process (GO:0046218)3.07046689
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.06976231
45termination of RNA polymerase III transcription (GO:0006386)3.06976231
46kynurenine metabolic process (GO:0070189)3.05211549
47cell proliferation in forebrain (GO:0021846)3.02928558
48sulfation (GO:0051923)2.97727389
49regulation of glomerulus development (GO:0090192)2.97132647
50protein K6-linked ubiquitination (GO:0085020)2.96316629
51fucose catabolic process (GO:0019317)2.93961316
52L-fucose metabolic process (GO:0042354)2.93961316
53L-fucose catabolic process (GO:0042355)2.93961316
54protein targeting to mitochondrion (GO:0006626)2.91095290
55meiosis I (GO:0007127)2.90597161
56negative regulation of transcription regulatory region DNA binding (GO:2000678)2.89340620
57respiratory chain complex IV assembly (GO:0008535)2.88229608
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86785762
59somite development (GO:0061053)2.86460041
60tRNA processing (GO:0008033)2.86150471
61ATP biosynthetic process (GO:0006754)2.85939398
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82767614
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82767614
64preassembly of GPI anchor in ER membrane (GO:0016254)2.79533798
65establishment of protein localization to mitochondrion (GO:0072655)2.77464321
66cellular response to ATP (GO:0071318)2.74095403
67terpenoid biosynthetic process (GO:0016114)2.73817485
68rRNA metabolic process (GO:0016072)2.73264460
69tryptophan metabolic process (GO:0006568)2.72455928
70mitochondrial RNA metabolic process (GO:0000959)2.72168187
71positive regulation of protein homooligomerization (GO:0032464)2.72058148
72regulation of female receptivity (GO:0045924)2.67789855
73magnesium ion transport (GO:0015693)2.66942121
74rRNA processing (GO:0006364)2.66402374
75peptidyl-histidine modification (GO:0018202)2.65425723
76purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65067089
77protein localization to mitochondrion (GO:0070585)2.63927284
78GPI anchor metabolic process (GO:0006505)2.63309463
79positive regulation of meiosis (GO:0045836)2.61317911
80cellular component biogenesis (GO:0044085)2.61150514
81purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60823530
82regulation of mitochondrial translation (GO:0070129)2.57085957
83tRNA modification (GO:0006400)2.56972869
84protein polyglutamylation (GO:0018095)2.54929414
85negative regulation of telomerase activity (GO:0051974)2.53150422
86mannosylation (GO:0097502)2.52130325
87base-excision repair, AP site formation (GO:0006285)2.50048915
88replication fork processing (GO:0031297)2.48910489
89positive regulation of cAMP-mediated signaling (GO:0043950)2.47721588
90hydrogen ion transmembrane transport (GO:1902600)2.47068525
91positive regulation of meiotic cell cycle (GO:0051446)2.46672967
92mitochondrion morphogenesis (GO:0070584)2.46425621
93negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.46423282
94indole-containing compound metabolic process (GO:0042430)2.45435995
95S-adenosylmethionine metabolic process (GO:0046500)2.44658734
96regulation of DNA endoreduplication (GO:0032875)2.43889097
97regulation of neurotransmitter uptake (GO:0051580)2.39760912
98parturition (GO:0007567)2.38643306
99ncRNA processing (GO:0034470)2.36265892
100proton transport (GO:0015992)2.35096308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.72954444
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71744304
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.24550764
4VDR_22108803_ChIP-Seq_LS180_Human3.23126023
5ZNF274_21170338_ChIP-Seq_K562_Hela3.10956955
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89023237
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88694177
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84550124
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69023458
10EZH2_22144423_ChIP-Seq_EOC_Human2.65749572
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.40780769
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.40315171
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23417606
14MYC_18940864_ChIP-ChIP_HL60_Human2.14280212
15VDR_23849224_ChIP-Seq_CD4+_Human2.07166394
16SRF_21415370_ChIP-Seq_HL-1_Mouse1.95646296
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95486607
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94815694
19IGF1R_20145208_ChIP-Seq_DFB_Human1.94733724
20ELK1_19687146_ChIP-ChIP_HELA_Human1.93773720
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83490888
22TP53_22573176_ChIP-Seq_HFKS_Human1.79737800
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77936717
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74164044
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70811486
26EWS_26573619_Chip-Seq_HEK293_Human1.69118129
27FOXP3_21729870_ChIP-Seq_TREG_Human1.67529127
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66560829
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62401860
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59496832
31GBX2_23144817_ChIP-Seq_PC3_Human1.56976165
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50355758
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50229422
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.48871056
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46486362
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43802295
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41363165
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39994956
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39634315
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38745401
41RNF2_27304074_Chip-Seq_NSC_Mouse1.38575272
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35133417
43IRF1_19129219_ChIP-ChIP_H3396_Human1.34819620
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34156384
45NCOR_22424771_ChIP-Seq_293T_Human1.32774510
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.32193764
47FUS_26573619_Chip-Seq_HEK293_Human1.31722193
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31652723
49PHF8_20622853_ChIP-Seq_HELA_Human1.29301469
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.28892394
51RBPJ_21746931_ChIP-Seq_IB4_Human1.28066650
52GABP_19822575_ChIP-Seq_HepG2_Human1.27206063
53ER_23166858_ChIP-Seq_MCF-7_Human1.27202223
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26857875
55ETV1_20927104_ChIP-Seq_GIST48_Human1.25380242
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25141872
57TTF2_22483619_ChIP-Seq_HELA_Human1.24606299
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.22568380
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22233226
60P300_19829295_ChIP-Seq_ESCs_Human1.17655809
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17466627
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16261419
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14878698
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.14878698
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.13243907
66GATA6_21074721_ChIP-Seq_CACO-2_Human1.13094647
67AR_20517297_ChIP-Seq_VCAP_Human1.12987348
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12779941
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11323984
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09230922
71LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08989643
72PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08656927
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08593906
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07564789
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05721947
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05337456
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04217620
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04201883
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03883215
80NANOG_19829295_ChIP-Seq_ESCs_Human1.03582583
81SOX2_19829295_ChIP-Seq_ESCs_Human1.03582583
82HNFA_21074721_ChIP-Seq_CACO-2_Human1.02980526
83HOXB7_26014856_ChIP-Seq_BT474_Human1.02866343
84NANOG_20526341_ChIP-Seq_ESCs_Human1.02554888
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.02300743
86NFYB_21822215_ChIP-Seq_K562_Human1.01758167
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00946099
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00679182
89ERA_21632823_ChIP-Seq_H3396_Human0.98468638
90KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97929863
91SALL1_21062744_ChIP-ChIP_HESCs_Human0.97761708
92EED_16625203_ChIP-ChIP_MESCs_Mouse0.94243503
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.93420611
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92934870
95CBP_20019798_ChIP-Seq_JUKART_Human0.92934870
96NFYA_21822215_ChIP-Seq_K562_Human0.92878955
97EZH2_27304074_Chip-Seq_ESCs_Mouse0.92806436
98CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91275557
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91197823
100TAF15_26573619_Chip-Seq_HEK293_Human0.90501481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland4.26067318
2MP0006292_abnormal_olfactory_placode3.49403478
3MP0002837_dystrophic_cardiac_calcinosis2.61704794
4MP0002160_abnormal_reproductive_system2.61155411
5MP0003646_muscle_fatigue2.56470464
6MP0008877_abnormal_DNA_methylation2.35759804
7MP0008995_early_reproductive_senescence2.34391248
8MP0001986_abnormal_taste_sensitivity2.32663189
9MP0005389_reproductive_system_phenotype2.24480275
10MP0004885_abnormal_endolymph2.19357305
11MP0002138_abnormal_hepatobiliary_system2.18060890
12MP0002102_abnormal_ear_morphology2.16623425
13MP0004147_increased_porphyrin_level2.09772887
14MP0002876_abnormal_thyroid_physiology2.08745006
15MP0003786_premature_aging2.06901741
16MP0000631_abnormal_neuroendocrine_gland1.97342212
17MP0001968_abnormal_touch/_nociception1.93797379
18MP0003195_calcinosis1.92127479
19MP0008872_abnormal_physiological_respon1.84925915
20MP0001485_abnormal_pinna_reflex1.83998609
21MP0001661_extended_life_span1.80082141
22MP0000372_irregular_coat_pigmentation1.79825190
23MP0006036_abnormal_mitochondrial_physio1.79299087
24MP0006072_abnormal_retinal_apoptosis1.78299966
25MP0004145_abnormal_muscle_electrophysio1.73087214
26MP0000678_abnormal_parathyroid_gland1.68008212
27MP0005551_abnormal_eye_electrophysiolog1.65807472
28MP0002736_abnormal_nociception_after1.61874349
29MP0003938_abnormal_ear_development1.59029910
30MP0002163_abnormal_gland_morphology1.58507242
31MP0000049_abnormal_middle_ear1.58203141
32MP0005423_abnormal_somatic_nervous1.53195723
33MP0003718_maternal_effect1.49168827
34MP0005670_abnormal_white_adipose1.44604076
35MP0002272_abnormal_nervous_system1.39809626
36MP0009046_muscle_twitch1.39610514
37MP0002638_abnormal_pupillary_reflex1.37785498
38MP0008875_abnormal_xenobiotic_pharmacok1.37074435
39MP0005360_urolithiasis1.35790619
40MP0001919_abnormal_reproductive_system1.35646355
41MP0009745_abnormal_behavioral_response1.34972477
42MP0002210_abnormal_sex_determination1.29583397
43MP0002735_abnormal_chemical_nociception1.27057673
44MP0003119_abnormal_digestive_system1.24721187
45MP0005379_endocrine/exocrine_gland_phen1.22539366
46MP0006035_abnormal_mitochondrial_morpho1.21736860
47MP0003567_abnormal_fetal_cardiomyocyte1.17700034
48MP0004134_abnormal_chest_morphology1.16924898
49MP0002277_abnormal_respiratory_mucosa1.14937646
50MP0003283_abnormal_digestive_organ1.14103107
51MP0003787_abnormal_imprinting1.14057881
52MP0002938_white_spotting1.14039603
53MP0001929_abnormal_gametogenesis1.11868519
54MP0004142_abnormal_muscle_tone1.11461131
55MP0005253_abnormal_eye_physiology1.09890751
56MP0005645_abnormal_hypothalamus_physiol1.09355820
57MP0000653_abnormal_sex_gland1.08290261
58MP0001145_abnormal_male_reproductive1.03443377
59MP0004133_heterotaxia1.02806049
60MP0008775_abnormal_heart_ventricle1.02364588
61MP0006276_abnormal_autonomic_nervous0.99356421
62MP0005410_abnormal_fertilization0.99028783
63MP0005084_abnormal_gallbladder_morpholo0.97511640
64MP0009379_abnormal_foot_pigmentation0.94307395
65MP0002751_abnormal_autonomic_nervous0.93907864
66MP0008058_abnormal_DNA_repair0.93511790
67MP0004215_abnormal_myocardial_fiber0.92962578
68MP0001502_abnormal_circadian_rhythm0.92941975
69MP0001486_abnormal_startle_reflex0.90769696
70MP0003136_yellow_coat_color0.89287748
71MP0000013_abnormal_adipose_tissue0.88674785
72MP0005636_abnormal_mineral_homeostasis0.88605967
73MP0003693_abnormal_embryo_hatching0.88537375
74MP0001764_abnormal_homeostasis0.88459414
75MP0003698_abnormal_male_reproductive0.88105941
76MP0003011_delayed_dark_adaptation0.87963249
77MP0008789_abnormal_olfactory_epithelium0.86791869
78MP0001119_abnormal_female_reproductive0.86775002
79MP0005332_abnormal_amino_acid0.85302607
80MP0003137_abnormal_impulse_conducting0.85112510
81MP0002733_abnormal_thermal_nociception0.84506521
82MP0001293_anophthalmia0.83867063
83MP0004130_abnormal_muscle_cell0.83609188
84MP0002064_seizures0.82965603
85MP0001963_abnormal_hearing_physiology0.81592392
86MP0003936_abnormal_reproductive_system0.81387646
87MP0002734_abnormal_mechanical_nocicepti0.80706301
88MP0001970_abnormal_pain_threshold0.80486288
89MP0005195_abnormal_posterior_eye0.78948185
90MP0002557_abnormal_social/conspecific_i0.78067140
91MP0001905_abnormal_dopamine_level0.77794867
92MP0005171_absent_coat_pigmentation0.77686598
93MP0003937_abnormal_limbs/digits/tail_de0.75107789
94MP0003186_abnormal_redox_activity0.74365808
95MP0002095_abnormal_skin_pigmentation0.74120836
96MP0004957_abnormal_blastocyst_morpholog0.74014685
97MP0001440_abnormal_grooming_behavior0.73245148
98MP0000026_abnormal_inner_ear0.69762922
99MP0002572_abnormal_emotion/affect_behav0.68063671
100MP0003880_abnormal_central_pattern0.67783226

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.03989777
2Acute encephalopathy (HP:0006846)3.80141909
3Abnormal mitochondria in muscle tissue (HP:0008316)3.65926905
4Increased CSF lactate (HP:0002490)3.48212612
5Mitochondrial inheritance (HP:0001427)3.48054457
6Progressive macrocephaly (HP:0004481)3.42219955
7Pendular nystagmus (HP:0012043)3.26306874
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.20533023
9Short 1st metacarpal (HP:0010034)3.20533023
10Congenital stationary night blindness (HP:0007642)3.01656324
11Pancreatic cysts (HP:0001737)2.97692115
12Abnormality of alanine metabolism (HP:0010916)2.95720862
13Hyperalaninemia (HP:0003348)2.95720862
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.95720862
153-Methylglutaconic aciduria (HP:0003535)2.88502555
16Congenital, generalized hypertrichosis (HP:0004540)2.82569444
17Pancreatic fibrosis (HP:0100732)2.82344445
18Abnormality of the 1st metacarpal (HP:0010009)2.81299380
19True hermaphroditism (HP:0010459)2.78036979
20Abnormality of the renal collecting system (HP:0004742)2.77086149
21Type II lissencephaly (HP:0007260)2.75977891
22Methylmalonic acidemia (HP:0002912)2.68413882
23Hyperthyroidism (HP:0000836)2.63334658
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61729821
25Hepatocellular necrosis (HP:0001404)2.60997303
26Absent thumb (HP:0009777)2.56921721
27Lipid accumulation in hepatocytes (HP:0006561)2.51243940
28Increased hepatocellular lipid droplets (HP:0006565)2.51189328
29Cerebral edema (HP:0002181)2.49994670
30Abnormality of DNA repair (HP:0003254)2.45408349
31Hypoplasia of the uterus (HP:0000013)2.45070424
32Methylmalonic aciduria (HP:0012120)2.44351559
33Aplasia/hypoplasia of the uterus (HP:0008684)2.43854984
34Increased serum lactate (HP:0002151)2.43418820
35Submucous cleft hard palate (HP:0000176)2.42398421
36Abnormality of midbrain morphology (HP:0002418)2.41953479
37Molar tooth sign on MRI (HP:0002419)2.41953479
38Abnormal rod and cone electroretinograms (HP:0008323)2.41432426
39Abnormality of the proximal phalanges of the hand (HP:0009834)2.40399604
40Genetic anticipation (HP:0003743)2.40306860
41Hepatic necrosis (HP:0002605)2.39971050
42Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.38640215
43Abolished electroretinogram (ERG) (HP:0000550)2.38054428
44Stenosis of the external auditory canal (HP:0000402)2.37213220
45Severe muscular hypotonia (HP:0006829)2.37160087
46Hyperglycinemia (HP:0002154)2.29517433
47Nephronophthisis (HP:0000090)2.29167270
48Short tibia (HP:0005736)2.28918511
49Renal Fanconi syndrome (HP:0001994)2.28679978
50Ectopic kidney (HP:0000086)2.27873013
51Lactic acidosis (HP:0003128)2.25938540
52Adrenal hypoplasia (HP:0000835)2.21358120
53Abnormality of the phalanges of the 5th finger (HP:0004213)2.18782543
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.16818461
55Hypoplasia of the pons (HP:0012110)2.15904843
56Duplicated collecting system (HP:0000081)2.14828807
57Agitation (HP:0000713)2.13764374
58Abnormality of the nasal septum (HP:0000419)2.13166079
59Abnormal number of erythroid precursors (HP:0012131)2.11711901
60Truncus arteriosus (HP:0001660)2.08719748
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08209707
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07495757
63Short phalanx of the thumb (HP:0009660)2.07454661
64Abnormality of the middle phalanges of the toes (HP:0010183)2.05420422
65Abnormality of the renal cortex (HP:0011035)2.05180193
66Abnormality of the pons (HP:0007361)2.04569312
67Reticulocytopenia (HP:0001896)2.04323682
68Abnormality of cells of the erythroid lineage (HP:0012130)2.01652876
69Male pseudohermaphroditism (HP:0000037)2.01092890
70Optic disc pallor (HP:0000543)1.99434636
71Sclerocornea (HP:0000647)1.95893530
72Degeneration of the lateral corticospinal tracts (HP:0002314)1.94280182
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94280182
74Lethargy (HP:0001254)1.93669011
75Pallor (HP:0000980)1.92781946
76Fused cervical vertebrae (HP:0002949)1.91351913
77Horseshoe kidney (HP:0000085)1.90311819
78Asplenia (HP:0001746)1.90288094
79Abnormality of urine glucose concentration (HP:0011016)1.90224760
80Glycosuria (HP:0003076)1.90224760
81Hyperglycinuria (HP:0003108)1.89248027
82Abnormality of homocysteine metabolism (HP:0010919)1.89167202
83Homocystinuria (HP:0002156)1.89167202
84Congenital sensorineural hearing impairment (HP:0008527)1.88635447
85Short hallux (HP:0010109)1.88387320
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.87990065
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.87985998
88Symphalangism affecting the phalanges of the hand (HP:0009773)1.87377651
89Renal cortical cysts (HP:0000803)1.87164114
90Respiratory failure (HP:0002878)1.86799636
91Abnormality of serum amino acid levels (HP:0003112)1.84971133
92Abnormality of the renal medulla (HP:0100957)1.83067490
93Humeroradial synostosis (HP:0003041)1.82234851
94Synostosis involving the elbow (HP:0003938)1.82234851
95Supernumerary spleens (HP:0009799)1.80328047
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79744697
97Tachypnea (HP:0002789)1.79397561
98Increased corneal curvature (HP:0100692)1.78753569
99Keratoconus (HP:0000563)1.78753569
100Chromsome breakage (HP:0040012)1.77593396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK13.24422648
2TLK13.00392268
3NUAK12.97353180
4FRK2.95455376
5TAOK32.86994287
6ADRBK22.74871257
7BUB12.73086181
8EIF2AK32.57739066
9EIF2AK12.57697588
10MAP4K22.55742786
11STK392.45599651
12STK162.44937875
13OXSR12.32073828
14PINK12.27820780
15WNK42.20484943
16ACVR1B2.19833293
17PLK21.88445698
18PLK41.77338921
19BMPR1B1.76986465
20NME11.66536081
21ZAK1.62621288
22INSRR1.54695142
23PHKG21.51727582
24PHKG11.51727582
25MKNK21.49788768
26PDK21.49643651
27WNK31.32245446
28TXK1.25588794
29MAPKAPK31.24342214
30CLK11.16826639
31CDC71.15078110
32MAPK131.11850939
33TESK21.01607517
34CSNK1G31.00629912
35RPS6KA51.00492772
36NTRK30.97947570
37CSNK1G20.95190007
38MAP3K40.93000095
39TIE10.91957879
40CSNK1G10.89091350
41MKNK10.88186629
42DYRK20.85851389
43PRKCG0.84492440
44PRKCE0.82921384
45AURKA0.81970886
46TEC0.79815777
47MST40.78860022
48CSNK1A1L0.76023470
49PLK10.75932784
50SRPK10.70254884
51BCKDK0.69864711
52VRK10.68494987
53CSNK1A10.68332500
54MAP2K60.67187340
55MUSK0.65574419
56PLK30.64417762
57ADRBK10.64166194
58EIF2AK20.60658200
59IKBKB0.60559531
60CSNK2A10.60041821
61PRKACA0.59886891
62MAP2K10.59126762
63PRKCI0.55217490
64ERBB30.53802139
65MAP2K70.53637161
66TRIM280.53317522
67ATR0.52643435
68STK30.51870290
69CDK190.51070727
70MARK30.50396934
71MAP2K20.50145699
72CAMK2A0.50098017
73PRKD20.49150162
74CSNK2A20.44709948
75VRK20.44560170
76ITK0.43881875
77PRKCQ0.43233364
78PIM10.43044560
79CHEK20.42525268
80PRKCA0.40609640
81PIK3CA0.39292746
82NEK10.39249886
83AURKB0.38962831
84DAPK20.38952300
85WEE10.38493795
86SGK10.37482413
87RPS6KA40.37424532
88MINK10.37137379
89CASK0.36274359
90PRKACG0.35641210
91OBSCN0.35220848
92MAPKAPK50.34944637
93GRK50.34568728
94ATM0.32775860
95CDK90.31558218
96CSNK1E0.31277775
97GRK60.29073178
98PAK30.28918489
99CDK80.28862498
100CSNK1D0.28644260

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.64755883
2Parkinsons disease_Homo sapiens_hsa050123.15842318
3Ribosome_Homo sapiens_hsa030102.96228145
4RNA polymerase_Homo sapiens_hsa030202.52349384
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50223424
6Sulfur metabolism_Homo sapiens_hsa009202.45434546
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.42504905
8Proteasome_Homo sapiens_hsa030502.37919467
9Protein export_Homo sapiens_hsa030602.27280755
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26292745
11Alzheimers disease_Homo sapiens_hsa050102.14371956
12Huntingtons disease_Homo sapiens_hsa050162.13449483
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.04688393
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94671429
15Homologous recombination_Homo sapiens_hsa034401.93596288
16RNA degradation_Homo sapiens_hsa030181.88022886
17Selenocompound metabolism_Homo sapiens_hsa004501.80368017
18Basal transcription factors_Homo sapiens_hsa030221.78788227
19Cardiac muscle contraction_Homo sapiens_hsa042601.76129709
20One carbon pool by folate_Homo sapiens_hsa006701.75076000
21Phototransduction_Homo sapiens_hsa047441.73842555
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72837722
23Nitrogen metabolism_Homo sapiens_hsa009101.57209940
24Linoleic acid metabolism_Homo sapiens_hsa005911.54378624
25Fanconi anemia pathway_Homo sapiens_hsa034601.53018130
26Nicotine addiction_Homo sapiens_hsa050331.52958916
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49939761
28RNA transport_Homo sapiens_hsa030131.39054672
29Butanoate metabolism_Homo sapiens_hsa006501.32529078
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29824995
31Regulation of autophagy_Homo sapiens_hsa041401.29744076
32Spliceosome_Homo sapiens_hsa030401.24905594
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22588111
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22450910
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21702828
36DNA replication_Homo sapiens_hsa030301.20152462
37Pyrimidine metabolism_Homo sapiens_hsa002401.19406033
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18461002
39Propanoate metabolism_Homo sapiens_hsa006401.16757654
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.15628227
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11735772
42Asthma_Homo sapiens_hsa053101.11086728
43Tryptophan metabolism_Homo sapiens_hsa003801.10739073
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97489109
45Olfactory transduction_Homo sapiens_hsa047400.97227658
46Chemical carcinogenesis_Homo sapiens_hsa052040.96059203
47Steroid biosynthesis_Homo sapiens_hsa001000.95888730
48Taste transduction_Homo sapiens_hsa047420.92205533
49Purine metabolism_Homo sapiens_hsa002300.91981984
50Caffeine metabolism_Homo sapiens_hsa002320.90478092
51Retinol metabolism_Homo sapiens_hsa008300.89522112
52Ether lipid metabolism_Homo sapiens_hsa005650.87714780
53Morphine addiction_Homo sapiens_hsa050320.85965261
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83777665
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83193534
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.83111266
57Collecting duct acid secretion_Homo sapiens_hsa049660.81845734
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81625557
59Mismatch repair_Homo sapiens_hsa034300.81424163
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77379315
61Metabolic pathways_Homo sapiens_hsa011000.76518078
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.75670848
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74362329
64Fat digestion and absorption_Homo sapiens_hsa049750.72626493
65Nucleotide excision repair_Homo sapiens_hsa034200.72402824
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71297253
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70230469
68beta-Alanine metabolism_Homo sapiens_hsa004100.69984778
69Sulfur relay system_Homo sapiens_hsa041220.69599161
70Folate biosynthesis_Homo sapiens_hsa007900.69170741
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65793298
72Peroxisome_Homo sapiens_hsa041460.64659999
73Primary immunodeficiency_Homo sapiens_hsa053400.59201855
74Base excision repair_Homo sapiens_hsa034100.57932047
75Insulin secretion_Homo sapiens_hsa049110.57722520
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.54788950
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52713270
78GABAergic synapse_Homo sapiens_hsa047270.52685139
79p53 signaling pathway_Homo sapiens_hsa041150.51052842
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.46953100
81Fatty acid elongation_Homo sapiens_hsa000620.45217133
82Type I diabetes mellitus_Homo sapiens_hsa049400.44901105
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43770360
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42686760
85Vitamin digestion and absorption_Homo sapiens_hsa049770.42191794
86Oocyte meiosis_Homo sapiens_hsa041140.42154204
87Tyrosine metabolism_Homo sapiens_hsa003500.41911424
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41648133
89Systemic lupus erythematosus_Homo sapiens_hsa053220.39472607
90Glycerolipid metabolism_Homo sapiens_hsa005610.38137291
91Mineral absorption_Homo sapiens_hsa049780.37380339
92Dorso-ventral axis formation_Homo sapiens_hsa043200.37247702
93Serotonergic synapse_Homo sapiens_hsa047260.36653571
94Circadian entrainment_Homo sapiens_hsa047130.34022521
95Pyruvate metabolism_Homo sapiens_hsa006200.33019570
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31303001
97Glutathione metabolism_Homo sapiens_hsa004800.30799466
98Arachidonic acid metabolism_Homo sapiens_hsa005900.30464778
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29357901
100Autoimmune thyroid disease_Homo sapiens_hsa053200.29252072

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