RHOV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.13294514
2establishment of skin barrier (GO:0061436)6.32304180
3regulation of water loss via skin (GO:0033561)6.27363300
4molting cycle (GO:0042303)6.09029254
5hair cycle (GO:0042633)6.09029254
6keratinization (GO:0031424)5.43266672
7ribosomal small subunit biogenesis (GO:0042274)5.14142464
8intermediate filament organization (GO:0045109)4.86202356
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.78011412
10positive regulation of keratinocyte differentiation (GO:0045618)4.57383843
11establishment of apical/basal cell polarity (GO:0035089)4.54583262
12multicellular organismal water homeostasis (GO:0050891)4.30654279
13sphingoid metabolic process (GO:0046519)4.22718357
14keratinocyte differentiation (GO:0030216)4.21493999
15atrioventricular valve morphogenesis (GO:0003181)4.21016413
16regulation of ruffle assembly (GO:1900027)4.16629131
17hemidesmosome assembly (GO:0031581)4.05494704
18positive regulation of epidermal cell differentiation (GO:0045606)4.04784620
19positive regulation of odontogenesis (GO:0042482)3.97764423
20polarized epithelial cell differentiation (GO:0030859)3.93096816
21neurofilament cytoskeleton organization (GO:0060052)3.92916583
22GDP-mannose metabolic process (GO:0019673)3.92210441
23peptide cross-linking (GO:0018149)3.90624493
24Golgi transport vesicle coating (GO:0048200)3.86738532
25COPI coating of Golgi vesicle (GO:0048205)3.86738532
26sphingosine metabolic process (GO:0006670)3.86459641
27water homeostasis (GO:0030104)3.70475717
28diol metabolic process (GO:0034311)3.64689307
29urea cycle (GO:0000050)3.56604318
30interferon-gamma secretion (GO:0072643)3.56042749
31regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.55676211
32negative regulation of membrane potential (GO:0045837)3.50235117
33establishment of monopolar cell polarity (GO:0061162)3.49103883
34establishment or maintenance of monopolar cell polarity (GO:0061339)3.49103883
35regulation of keratinocyte differentiation (GO:0045616)3.47278611
36negative regulation of dendrite morphogenesis (GO:0050774)3.45948834
37citrulline metabolic process (GO:0000052)3.45768749
38diaphragm development (GO:0060539)3.45090935
39axonemal dynein complex assembly (GO:0070286)3.44449075
40regulation of translational fidelity (GO:0006450)3.44265467
41positive regulation of Cdc42 GTPase activity (GO:0043089)3.44122305
42motile cilium assembly (GO:0044458)3.43985463
43regulation of apoptotic process involved in morphogenesis (GO:1902337)3.41821601
44intermediate filament cytoskeleton organization (GO:0045104)3.41639551
45epithelial cell-cell adhesion (GO:0090136)3.34425512
46intermediate filament-based process (GO:0045103)3.34219317
47cornea development in camera-type eye (GO:0061303)3.34206050
48activation of Rac GTPase activity (GO:0032863)3.32293644
49ear development (GO:0043583)3.32282853
50epidermal cell differentiation (GO:0009913)3.31253023
51spliceosomal tri-snRNP complex assembly (GO:0000244)3.29832764
52proline transport (GO:0015824)3.27564495
53epithelial cell differentiation involved in prostate gland development (GO:0060742)3.27264993
54proline biosynthetic process (GO:0006561)3.25442549
55eyelid development in camera-type eye (GO:0061029)3.23085030
56phagosome maturation (GO:0090382)3.21832335
57citrulline biosynthetic process (GO:0019240)3.19892556
58ATP hydrolysis coupled proton transport (GO:0015991)3.14759711
59energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.14759711
60homocysteine metabolic process (GO:0050667)3.11292412
61viral transcription (GO:0019083)3.08652044
62urea metabolic process (GO:0019627)3.08324673
63epidermis development (GO:0008544)3.06735254
64regulation of chromatin binding (GO:0035561)3.05960758
65response to food (GO:0032094)3.05943382
66primary alcohol catabolic process (GO:0034310)3.05940044
67ribonucleoprotein complex biogenesis (GO:0022613)3.04822618
68surfactant homeostasis (GO:0043129)3.04559741
69planar cell polarity pathway involved in neural tube closure (GO:0090179)3.04326732
70branching involved in salivary gland morphogenesis (GO:0060445)3.03092005
71cell migration in hindbrain (GO:0021535)2.99786631
72mitotic G1 DNA damage checkpoint (GO:0031571)2.96889817
73cell communication involved in cardiac conduction (GO:0086065)2.95954984
74synaptic vesicle maturation (GO:0016188)2.95022851
75maturation of SSU-rRNA (GO:0030490)2.94951661
76regulation of clathrin-mediated endocytosis (GO:2000369)2.93144657
77folic acid metabolic process (GO:0046655)2.92411212
78ectoderm development (GO:0007398)2.91962793
79tRNA methylation (GO:0030488)2.91088615
80transferrin transport (GO:0033572)2.90760923
81positive regulation of vesicle fusion (GO:0031340)2.89887782
82translational termination (GO:0006415)2.88163866
83negative regulation of T cell differentiation in thymus (GO:0033085)2.85237895
84detection of temperature stimulus involved in sensory perception (GO:0050961)2.85068697
85detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.85068697
86regulation of short-term neuronal synaptic plasticity (GO:0048172)2.85039380
87formation of translation preinitiation complex (GO:0001731)2.83490369
88ncRNA 3-end processing (GO:0043628)2.78340110
89positive regulation of regulated secretory pathway (GO:1903307)2.77381319
90regulation of epidermal cell differentiation (GO:0045604)2.76917018
91skin morphogenesis (GO:0043589)2.74950358
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74408687
93keratinocyte development (GO:0003334)2.74292289
94ribosome biogenesis (GO:0042254)2.73807992
95morphogenesis of embryonic epithelium (GO:0016331)2.73509561
96skeletal muscle organ development (GO:0060538)2.71201649
97keratinocyte proliferation (GO:0043616)2.70788655
98negative regulation of microtubule polymerization (GO:0031115)2.69658567
99ER overload response (GO:0006983)2.69151366
100synaptic vesicle exocytosis (GO:0016079)2.68682278
101long-chain fatty acid biosynthetic process (GO:0042759)2.68584411
102layer formation in cerebral cortex (GO:0021819)2.68209727
103translational elongation (GO:0006414)2.67927563
104negative regulation of transcription by competitive promoter binding (GO:0010944)2.66973774
105ferric iron transport (GO:0015682)2.66501022
106trivalent inorganic cation transport (GO:0072512)2.66501022
107nitrogen cycle metabolic process (GO:0071941)2.66462364
108calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.66214715
109retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65832601
110mitotic G1/S transition checkpoint (GO:0044819)2.65283333
111branching involved in mammary gland duct morphogenesis (GO:0060444)2.64929528
112G1 DNA damage checkpoint (GO:0044783)2.64592052
113membrane budding (GO:0006900)2.62921653
114mitotic chromosome condensation (GO:0007076)2.61867806
115diterpenoid biosynthetic process (GO:0016102)2.59346952
116detection of temperature stimulus (GO:0016048)2.58447079
117nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.57624839
118maternal placenta development (GO:0001893)2.57610643
119gap junction assembly (GO:0016264)2.57172878
120positive regulation of hair cycle (GO:0042635)2.56650575
121positive regulation of hair follicle development (GO:0051798)2.56650575
122hepatocyte differentiation (GO:0070365)2.56569597
123regulation of synaptic vesicle exocytosis (GO:2000300)2.55666380
124intestinal epithelial cell development (GO:0060576)2.55483262
125glutamate secretion (GO:0014047)2.55096521
126cell-substrate adherens junction assembly (GO:0007045)2.53987932
127focal adhesion assembly (GO:0048041)2.53987932
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52640376
129midgut development (GO:0007494)2.52356534
130regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.52332452
131adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.51961380
132regulation of epidermis development (GO:0045682)2.50948327
133negative regulation of cell fate specification (GO:0009996)2.50234510
134positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.49639487
135modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.48530296
136positive regulation by organism of defense response of other organism involved in symbiotic interact2.48530296
137modulation by symbiont of host immune response (GO:0052553)2.48530296
138positive regulation by symbiont of host defense response (GO:0052509)2.48530296
139modulation by symbiont of host defense response (GO:0052031)2.48530296
140modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48530296
141L-alpha-amino acid transmembrane transport (GO:1902475)2.47802996
142entrainment of circadian clock by photoperiod (GO:0043153)2.47315137
143biotin metabolic process (GO:0006768)2.46665371
144negative regulation of viral release from host cell (GO:1902187)2.46433043
145viral life cycle (GO:0019058)2.46223468
146DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.46034678
147cell differentiation involved in embryonic placenta development (GO:0060706)2.44213279
148cytoskeletal anchoring at plasma membrane (GO:0007016)2.42188146
149axon cargo transport (GO:0008088)2.39780924
150vesicle transport along microtubule (GO:0047496)2.39524157
151cellular response to arsenic-containing substance (GO:0071243)2.39334005
152regulation of NFAT protein import into nucleus (GO:0051532)2.36858314
153cytokine production involved in immune response (GO:0002367)2.28820902
154ceramide catabolic process (GO:0046514)2.27946351
155regulation of hair follicle development (GO:0051797)2.27916472
156protein localization to endosome (GO:0036010)2.26658371
157positive regulation of epidermis development (GO:0045684)2.26582859
158icosanoid secretion (GO:0032309)2.25964036
159arachidonic acid secretion (GO:0050482)2.25964036
160chemosensory behavior (GO:0007635)2.25551079
161neuronal action potential (GO:0019228)2.25449643
162regulation of regulated secretory pathway (GO:1903305)2.25260034
163detection of bacterium (GO:0016045)2.23557280
164sodium ion export (GO:0071436)2.22800273
165vocalization behavior (GO:0071625)2.22679556
166positive regulation of heat generation (GO:0031652)2.22177150
167sympathetic nervous system development (GO:0048485)2.22100364
168cellular potassium ion homeostasis (GO:0030007)2.21700674
169positive regulation of axon extension (GO:0045773)2.21391213
170negative regulation of dendrite development (GO:2000171)2.19962599
171dopamine receptor signaling pathway (GO:0007212)2.19099046
172negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.17716329
173regulation of synaptic vesicle transport (GO:1902803)2.17590136
174regulation of heart rate by cardiac conduction (GO:0086091)2.17046495
175regulation of phospholipase A2 activity (GO:0032429)2.16947109
176positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.16459461
177positive regulation of actin cytoskeleton reorganization (GO:2000251)2.15621290
178sphingolipid biosynthetic process (GO:0030148)2.15529302
179positive regulation of chemokine biosynthetic process (GO:0045080)2.13738269
180phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.12200908
181positive regulation of antigen processing and presentation (GO:0002579)2.11992074
182T cell mediated immunity (GO:0002456)2.10975662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.99771156
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.63966729
3E2F7_22180533_ChIP-Seq_HELA_Human2.73671837
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.59556462
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.29509698
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.13864886
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13141963
8MYC_22102868_ChIP-Seq_BL_Human2.10967055
9VDR_21846776_ChIP-Seq_THP-1_Human2.03452254
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98664883
11ZNF263_19887448_ChIP-Seq_K562_Human1.98251701
12P63_26484246_Chip-Seq_KERATINOCYTES_Human1.97149180
13ERG_21242973_ChIP-ChIP_JURKAT_Human1.95793160
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.89754868
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88801495
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88160885
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80371878
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.79828461
19AHR_22903824_ChIP-Seq_MCF-7_Human1.79552016
20XRN2_22483619_ChIP-Seq_HELA_Human1.73719792
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69775330
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69479379
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68956780
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68409325
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68252649
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64776167
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64293340
28SMC4_20622854_ChIP-Seq_HELA_Human1.60625701
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59253532
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58872436
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58721656
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.56776865
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55264876
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55103065
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54640257
36P68_20966046_ChIP-Seq_HELA_Human1.52507032
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.51340818
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51158006
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50455813
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.50267120
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49120110
42SOX2_20726797_ChIP-Seq_SW620_Human1.48799096
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46719469
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46353412
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42970007
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42935021
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.42917174
48KDM2B_26808549_Chip-Seq_K562_Human1.41784200
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41481097
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.41302838
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40776917
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40358147
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40358147
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.39867768
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.39089439
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39027407
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37325916
58* CREB1_26743006_Chip-Seq_LNCaP_Human1.36745442
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35861721
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35498085
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34899151
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34470125
63DCP1A_22483619_ChIP-Seq_HELA_Human1.33728678
64* LXR_22292898_ChIP-Seq_THP-1_Human1.33647022
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33252441
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.29766991
67KLF5_25053715_ChIP-Seq_YYC3_Human1.28143419
68* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27056594
69* RUNX1_27514584_Chip-Seq_MCF-7_Human1.25630592
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24489098
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24489098
72KDM2B_26808549_Chip-Seq_DND41_Human1.24168617
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.23931459
74EGR1_19032775_ChIP-ChIP_M12_Human1.23820898
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.23768378
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21902796
77KDM5A_27292631_Chip-Seq_BREAST_Human1.20386309
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18941146
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18088573
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14770692
81TCF7_22412390_ChIP-Seq_EML_Mouse1.14278324
82BCOR_27268052_Chip-Seq_Bcells_Human1.14140715
83CHD1_26751641_Chip-Seq_LNCaP_Human1.13983830
84* RACK7_27058665_Chip-Seq_MCF-7_Human1.13858691
85REST_21632747_ChIP-Seq_MESCs_Mouse1.13622090
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13409981
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12943394
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11967422
89CLOCK_20551151_ChIP-Seq_293T_Human1.11495202
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11375599
91* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10948550
92TP63_22573176_ChIP-Seq_HFKS_Human1.10502618
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07840374
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07749509
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06799545
96CTCF_27219007_Chip-Seq_Bcells_Human1.06356028
97RXR_22108803_ChIP-Seq_LS180_Human1.05909943
98TP63_23658742_ChIP-Seq_EP156T_Human1.05765984
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05367273
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05159215
101AR_21572438_ChIP-Seq_LNCaP_Human1.04948052
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04679358
103ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04296131
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.04223592
105CJUN_26792858_Chip-Seq_BT549_Human1.03364069
106* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02422426
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02310154
108ATF3_27146783_Chip-Seq_COLON_Human1.02216973
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01742200
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01515853
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00944367
112UBF1/2_26484160_Chip-Seq_HMECs_Human1.00835067
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99618768
114BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98749502
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98665092
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98348490
117GABP_19822575_ChIP-Seq_HepG2_Human0.97723430
118EED_16625203_ChIP-ChIP_MESCs_Mouse0.97619610
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97549211
120ELF5_23300383_ChIP-Seq_T47D_Human0.97462058
121E2F1_21310950_ChIP-Seq_MCF-7_Human0.97316402
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.97009465
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.96327338
124REST_18959480_ChIP-ChIP_MESCs_Mouse0.95493814
125EZH2_22144423_ChIP-Seq_EOC_Human0.95344142
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95205561
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94657455
128TTF2_22483619_ChIP-Seq_HELA_Human0.94423299
129TP53_18474530_ChIP-ChIP_U2OS_Human0.94176148
130ETS1_20019798_ChIP-Seq_JURKAT_Human0.92975219
131E2F1_20622854_ChIP-Seq_HELA_Human0.92732598
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92341042
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91745225
134ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91649383
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91629231
136TCF4_18268006_ChIP-ChIP_LS174T_Human0.90721490
137* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90000327
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87090821
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.87031852
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86068494
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85677101
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85249111
143ZNF274_21170338_ChIP-Seq_K562_Hela0.84850229
144* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84647443
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84603216
146CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84410456
147PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84300394
148* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.81010759
149JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80369487
150SA1_27219007_Chip-Seq_ERYTHROID_Human0.80326376
151RING1B_27294783_Chip-Seq_ESCs_Mouse0.79400253
152* TET1_21490601_ChIP-Seq_MESCs_Mouse0.78760743
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.78719953
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78234495
155JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77835916
156WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77746743
157SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77616632
158* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77027221
159CDX2_20551321_ChIP-Seq_CACO-2_Human0.75631434
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75626914
161TCF4_22108803_ChIP-Seq_LS180_Human0.75556736
162* SA1_27219007_Chip-Seq_Bcells_Human0.75453120
163TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75353440
164GATA6_25053715_ChIP-Seq_YYC3_Human0.74832526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.49745699
2MP0010234_abnormal_vibrissa_follicle5.01734548
3MP0002735_abnormal_chemical_nociception3.62682847
4MP0004858_abnormal_nervous_system3.60876191
5MP0001968_abnormal_touch/_nociception3.43107764
6MP0002254_reproductive_system_inflammat3.25338350
7MP0000579_abnormal_nail_morphology3.22574218
8MP0005275_abnormal_skin_tensile3.08867673
9MP0005501_abnormal_skin_physiology3.08512915
10MP0002736_abnormal_nociception_after2.90668779
11MP0003941_abnormal_skin_development2.70089565
12MP0004270_analgesia2.62693529
13MP0002098_abnormal_vibrissa_morphology2.61507384
14MP0010771_integument_phenotype2.60831527
15MP0000566_synostosis2.59364007
16MP0001216_abnormal_epidermal_layer2.55394158
17MP0004947_skin_inflammation2.50320024
18MP0002733_abnormal_thermal_nociception2.49410328
19MP0003453_abnormal_keratinocyte_physiol2.47476101
20MP0004381_abnormal_hair_follicle2.35708086
21MP0000647_abnormal_sebaceous_gland2.34347236
22MP0003303_peritoneal_inflammation2.11140596
23MP0010678_abnormal_skin_adnexa2.11016129
24MP0004859_abnormal_synaptic_plasticity2.08487320
25MP0001346_abnormal_lacrimal_gland2.06664401
26MP0002060_abnormal_skin_morphology2.04110037
27MP0002734_abnormal_mechanical_nocicepti2.01076660
28MP0005623_abnormal_meninges_morphology1.96248461
29MP0010030_abnormal_orbit_morphology1.89184924
30MP0001970_abnormal_pain_threshold1.87048088
31MP0003693_abnormal_embryo_hatching1.86355279
32MP0010386_abnormal_urinary_bladder1.80540509
33MP0000383_abnormal_hair_follicle1.77775503
34MP0000377_abnormal_hair_follicle1.77493084
35MP0000427_abnormal_hair_cycle1.72562280
36MP0004233_abnormal_muscle_weight1.59620195
37MP0003436_decreased_susceptibility_to1.52975787
38MP0003329_amyloid_beta_deposits1.51682189
39MP0003705_abnormal_hypodermis_morpholog1.50262118
40MP0000003_abnormal_adipose_tissue1.48728241
41MP0003566_abnormal_cell_adhesion1.43222568
42MP0000678_abnormal_parathyroid_gland1.43120180
43MP0000604_amyloidosis1.43106853
44MP0009046_muscle_twitch1.42218408
45MP0006276_abnormal_autonomic_nervous1.40578666
46MP0008260_abnormal_autophagy1.39021413
47MP0004957_abnormal_blastocyst_morpholog1.38698841
48MP0008875_abnormal_xenobiotic_pharmacok1.37974900
49MP0004782_abnormal_surfactant_physiolog1.32960403
50MP0005083_abnormal_biliary_tract1.25135874
51MP0010094_abnormal_chromosome_stability1.24012452
52MP0002184_abnormal_innervation1.23073629
53MP0003077_abnormal_cell_cycle1.22108920
54MP0001851_eye_inflammation1.18213872
55MP0001873_stomach_inflammation1.16622616
56MP0003635_abnormal_synaptic_transmissio1.16383400
57MP0000538_abnormal_urinary_bladder1.16358210
58MP0000367_abnormal_coat/_hair1.16238046
59MP0004510_myositis1.15752027
60MP0005076_abnormal_cell_differentiation1.15736231
61MP0002009_preneoplasia1.15600958
62MP0000467_abnormal_esophagus_morphology1.14021806
63MP0001984_abnormal_olfaction1.12944919
64MP0001191_abnormal_skin_condition1.11886224
65MP0002166_altered_tumor_susceptibility1.11794299
66MP0003111_abnormal_nucleus_morphology1.11697922
67MP0009379_abnormal_foot_pigmentation1.10821796
68MP0003879_abnormal_hair_cell1.10758956
69MP0005409_darkened_coat_color1.10113311
70MP0003183_abnormal_peptide_metabolism1.09126701
71MP0005451_abnormal_body_composition1.08603057
72MP0001881_abnormal_mammary_gland1.07779437
73MP0009931_abnormal_skin_appearance1.03237997
74MP0000013_abnormal_adipose_tissue1.01532890
75MP0002751_abnormal_autonomic_nervous1.01397920
76MP0003172_abnormal_lysosome_physiology1.00683839
77MP0004811_abnormal_neuron_physiology1.00664870
78MP0001501_abnormal_sleep_pattern1.00113112
79MP0002063_abnormal_learning/memory/cond0.97488694
80MP0009333_abnormal_splenocyte_physiolog0.96435529
81MP0009053_abnormal_anal_canal0.96148794
82MP0000350_abnormal_cell_proliferation0.92397950
83MP0003763_abnormal_thymus_physiology0.92371471
84MP0001986_abnormal_taste_sensitivity0.91237618
85MP0002249_abnormal_larynx_morphology0.91053867
86MP0009745_abnormal_behavioral_response0.87671588
87MP0005375_adipose_tissue_phenotype0.86716228
88MP0002064_seizures0.86627618
89MP0000762_abnormal_tongue_morphology0.85200957
90MP0001340_abnormal_eyelid_morphology0.84300711
91MP0001440_abnormal_grooming_behavior0.82587138
92MP0008932_abnormal_embryonic_tissue0.82402127
93MP0001348_abnormal_lacrimal_gland0.80983793
94MP0005058_abnormal_lysosome_morphology0.80131414
95MP0002067_abnormal_sensory_capabilities0.79998813
96MP0002909_abnormal_adrenal_gland0.79632306
97MP0002272_abnormal_nervous_system0.79506188
98MP0004043_abnormal_pH_regulation0.79168295
99MP0001243_abnormal_dermal_layer0.78807291
100MP0001533_abnormal_skeleton_physiology0.78523459
101MP0000537_abnormal_urethra_morphology0.78446132
102MP0003638_abnormal_response/metabolism_0.77974347
103MP0003300_gastrointestinal_ulcer0.77587067
104MP0001849_ear_inflammation0.77443969
105MP0002877_abnormal_melanocyte_morpholog0.77335109
106MP0003786_premature_aging0.75444778
107MP0002111_abnormal_tail_morphology0.75281009
108MP0002089_abnormal_postnatal_growth/wei0.75045598
109MP0000343_altered_response_to0.74797852
110MP0002006_tumorigenesis0.74214794
111MP0008058_abnormal_DNA_repair0.73834772
112MP0000490_abnormal_crypts_of0.72164541
113MP0000858_altered_metastatic_potential0.71299546
114MP0004264_abnormal_extraembryonic_tissu0.70898215
115MP0008961_abnormal_basal_metabolism0.69374925
116MP0003315_abnormal_perineum_morphology0.69141705
117MP0003075_altered_response_to0.68533086
118MP0000955_abnormal_spinal_cord0.67213185
119MP0002148_abnormal_hypersensitivity_rea0.66938897
120MP0010352_gastrointestinal_tract_polyps0.66639055
121MP0001672_abnormal_embryogenesis/_devel0.66088175
122MP0005380_embryogenesis_phenotype0.66088175
123MP0003011_delayed_dark_adaptation0.66001362
124MP0003880_abnormal_central_pattern0.65969316
125MP0002080_prenatal_lethality0.65938854
126MP0003984_embryonic_growth_retardation0.65762667
127MP0002277_abnormal_respiratory_mucosa0.65051222
128MP0000778_abnormal_nervous_system0.65040647
129MP0002088_abnormal_embryonic_growth/wei0.64540458
130MP0000627_abnormal_mammary_gland0.64142112
131MP0008789_abnormal_olfactory_epithelium0.63568025
132MP0005166_decreased_susceptibility_to0.63245965
133MP0004185_abnormal_adipocyte_glucose0.62608839
134MP0000685_abnormal_immune_system0.62031846
135MP0001661_extended_life_span0.60523214
136MP0001188_hyperpigmentation0.60252839
137MP0005621_abnormal_cell_physiology0.59284701
138MP0002572_abnormal_emotion/affect_behav0.58996079
139MP0003448_altered_tumor_morphology0.58632597
140MP0008874_decreased_physiological_sensi0.57978423
141MP0009643_abnormal_urine_homeostasis0.57389907
142MP0004197_abnormal_fetal_growth/weight/0.57112735
143MP0010307_abnormal_tumor_latency0.55912343
144MP0009672_abnormal_birth_weight0.55515372
145MP0004019_abnormal_vitamin_homeostasis0.55146413
146MP0005394_taste/olfaction_phenotype0.54460873
147MP0005499_abnormal_olfactory_system0.54460873
148MP0002019_abnormal_tumor_incidence0.54451793
149MP0002086_abnormal_extraembryonic_tissu0.53606773
150MP0001697_abnormal_embryo_size0.52981712
151MP0003634_abnormal_glial_cell0.52327375
152MP0002882_abnormal_neuron_morphology0.50234282
153MP0009780_abnormal_chondrocyte_physiolo0.49493003
154MP0002557_abnormal_social/conspecific_i0.47205071
155MP0008004_abnormal_stomach_pH0.46856345
156MP0003045_fibrosis0.45291782
157MP0002234_abnormal_pharynx_morphology0.45211724
158MP0005023_abnormal_wound_healing0.45146178
159MP0005000_abnormal_immune_tolerance0.44653672

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)5.81117748
2Woolly hair (HP:0002224)4.72077881
3Plantar hyperkeratosis (HP:0007556)4.58889005
4Palmoplantar hyperkeratosis (HP:0000972)4.45470698
5Increased IgE level (HP:0003212)4.44675447
6Palmar hyperkeratosis (HP:0010765)4.07804006
7Congenital ichthyosiform erythroderma (HP:0007431)4.03876619
8Right ventricular cardiomyopathy (HP:0011663)4.03372226
9Fragile nails (HP:0001808)3.94222930
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.91775577
11Abnormality of nail color (HP:0100643)3.90077381
12Parakeratosis (HP:0001036)3.84599609
13Onycholysis (HP:0001806)3.79574725
14Supranuclear gaze palsy (HP:0000605)3.77883694
15Ulnar claw (HP:0001178)3.75845631
16Abnormal hair laboratory examination (HP:0003328)3.75188494
17Septate vagina (HP:0001153)3.68125408
18Curly hair (HP:0002212)3.67903339
19Lip pit (HP:0100267)3.64309390
20Oral leukoplakia (HP:0002745)3.56610408
21Erythema (HP:0010783)3.55993625
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.43428380
23Milia (HP:0001056)3.35283015
24Nail dystrophy (HP:0008404)3.32607703
25Pili torti (HP:0003777)3.28266615
26Abnormality of the salivary glands (HP:0010286)3.24910002
27Increased cerebral lipofuscin (HP:0011813)3.20262732
28Sparse lateral eyebrow (HP:0005338)3.19154633
29Chronic bronchitis (HP:0004469)3.02330632
30Myokymia (HP:0002411)2.98114161
31Squamous cell carcinoma (HP:0002860)2.89855903
32Conjunctival hamartoma (HP:0100780)2.85992568
33Mutism (HP:0002300)2.83897890
34Progressive muscle weakness (HP:0003323)2.79143395
35Abnormal blistering of the skin (HP:0008066)2.79005437
36Ridged nail (HP:0001807)2.77597387
37Thick nail (HP:0001805)2.75223340
38Erythroderma (HP:0001019)2.69432334
39Popliteal pterygium (HP:0009756)2.68566057
40Natal tooth (HP:0000695)2.68334720
41Apathy (HP:0000741)2.67332527
42Ventricular fibrillation (HP:0001663)2.65942417
43Nasolacrimal duct obstruction (HP:0000579)2.63031465
44Diminished motivation (HP:0000745)2.62570662
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56650239
46Trismus (HP:0000211)2.56300024
47Abnormal respiratory motile cilium physiology (HP:0012261)2.54168942
48Ragged-red muscle fibers (HP:0003200)2.53211591
49Eczematoid dermatitis (HP:0000976)2.52553325
50Hyperacusis (HP:0010780)2.46826873
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.45749580
52Abnormal respiratory epithelium morphology (HP:0012253)2.44903630
53Abnormal respiratory motile cilium morphology (HP:0005938)2.44903630
54Disinhibition (HP:0000734)2.43629011
55Breast hypoplasia (HP:0003187)2.42982347
56Elbow flexion contracture (HP:0002987)2.39302624
57Hypercortisolism (HP:0001578)2.39284752
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.39233957
59Rhinitis (HP:0012384)2.38719333
60Bronchiectasis (HP:0002110)2.37056114
61Hypohidrosis (HP:0000966)2.34281736
62Advanced eruption of teeth (HP:0006288)2.33850150
63Aplasia cutis congenita (HP:0001057)2.33600158
64Fasciculations (HP:0002380)2.32718575
65Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.32489864
66Akinesia (HP:0002304)2.30160232
67Flat acetabular roof (HP:0003180)2.28529262
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.24261274
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23642515
70Brittle hair (HP:0002299)2.23508084
71Segmental peripheral demyelination/remyelination (HP:0003481)2.22982383
72Visual hallucinations (HP:0002367)2.21861192
73Abnormality of small intestinal villus morphology (HP:0011472)2.21422302
74Villous atrophy (HP:0011473)2.21422302
75Selective tooth agenesis (HP:0001592)2.20644074
76Hyporeflexia of lower limbs (HP:0002600)2.20099434
77Abnormality of liposaccharide metabolism (HP:0010968)2.19686897
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.19686897
79Abnormality of glycolipid metabolism (HP:0010969)2.19686897
80Absent eyelashes (HP:0000561)2.15566923
81Abnormal ciliary motility (HP:0012262)2.15133403
82Anhidrosis (HP:0000970)2.14779690
83Acanthosis nigricans (HP:0000956)2.14681816
84Axonal loss (HP:0003447)2.12775339
85Absent/shortened dynein arms (HP:0200106)2.12416351
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.12416351
87Distal lower limb muscle weakness (HP:0009053)2.12131705
88Corneal erosion (HP:0200020)2.12082724
89Dysautonomia (HP:0002459)2.10980492
90Amelogenesis imperfecta (HP:0000705)2.09471446
91Hamartoma of the eye (HP:0010568)2.06390805
92Hypoplastic labia majora (HP:0000059)2.03700996
93Ankle clonus (HP:0011448)2.03297389
94Blepharitis (HP:0000498)2.02429110
95Sparse scalp hair (HP:0002209)2.01431297
96Palmoplantar keratoderma (HP:0000982)1.97910702
97Abnormality of the distal phalanges of the toes (HP:0010182)1.97711284
98Unilateral renal agenesis (HP:0000122)1.97492773
99Alopecia of scalp (HP:0002293)1.95988332
100Atrophic scars (HP:0001075)1.95017315
101Recurrent otitis media (HP:0000403)1.94548856
102Short nail (HP:0001799)1.93973128
103Abnormality of macrophages (HP:0004311)1.93675580
104Ectropion (HP:0000656)1.93494822
105Neuronal loss in central nervous system (HP:0002529)1.93144025
106Termporal pattern (HP:0011008)1.92980416
107Insidious onset (HP:0003587)1.92980416
108Focal seizures (HP:0007359)1.92722987
109Abnormality of the labia majora (HP:0012881)1.92125548
110Neurofibrillary tangles (HP:0002185)1.90621486
111Interstitial pulmonary disease (HP:0006530)1.89632392
112Polyphagia (HP:0002591)1.89606378
113Recurrent abscess formation (HP:0002722)1.87499228
114Pterygium (HP:0001059)1.86736348
115Hypoplasia of dental enamel (HP:0006297)1.86335862
116Hand muscle atrophy (HP:0009130)1.86269535
117Testicular atrophy (HP:0000029)1.85857145
118Progressive cerebellar ataxia (HP:0002073)1.84660305
119Abnormality of the vocal cords (HP:0008777)1.84491287
120Abnormality of the nasal mucosa (HP:0000433)1.83243771
121Absent eyebrow (HP:0002223)1.83040341
122Hyperparathyroidism (HP:0000843)1.82541543
123Upper limb muscle weakness (HP:0003484)1.82416606
124Failure to thrive in infancy (HP:0001531)1.82094969
125Papilledema (HP:0001085)1.81080469
126Rapidly progressive (HP:0003678)1.79977333
127Abnormality of the Achilles tendon (HP:0005109)1.79611955
128Loss of speech (HP:0002371)1.79512348
129Abnormality of the dental root (HP:0006486)1.78736340
130Taurodontia (HP:0000679)1.78736340
131Abnormality of permanent molar morphology (HP:0011071)1.78736340
132Proximal placement of thumb (HP:0009623)1.78676157
133Bell-shaped thorax (HP:0001591)1.78347206
134Cerebral inclusion bodies (HP:0100314)1.78266494
135Inappropriate behavior (HP:0000719)1.78255230
136Oligodontia (HP:0000677)1.78085762
137Achilles tendon contracture (HP:0001771)1.77685926
138Absence seizures (HP:0002121)1.77435509
139Deviation of the thumb (HP:0009603)1.76252395
140Gastrointestinal stroma tumor (HP:0100723)1.74336869
141Dysostosis multiplex (HP:0000943)1.74288866
142Microvesicular hepatic steatosis (HP:0001414)1.73862417
143Urticaria (HP:0001025)1.72541619
144Labial hypoplasia (HP:0000066)1.72178403
145Recurrent sinusitis (HP:0011108)1.71603181
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71053773
147Abnormality of the lacrimal duct (HP:0011481)1.70005117
148Agitation (HP:0000713)1.69542890
149Stomatitis (HP:0010280)1.69391517
150Nasal polyposis (HP:0100582)1.69005063
151Focal motor seizures (HP:0011153)1.68661489
152Male infertility (HP:0003251)1.68642414
153Ureteral duplication (HP:0000073)1.68385440
154Pruritus (HP:0000989)1.67882610
155Down-sloping shoulders (HP:0200021)1.67303553
156Bronchitis (HP:0012387)1.67005783
157Concave nail (HP:0001598)1.65924456
158Sparse eyelashes (HP:0000653)1.65828594
159Micronodular cirrhosis (HP:0001413)1.65691163
160Ulnar bowing (HP:0003031)1.65264997
161Abnormality of the gastric mucosa (HP:0004295)1.64920827
162Generalized tonic-clonic seizures (HP:0002069)1.64114741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.52096659
2MAP3K23.81993327
3SMG13.67767435
4EEF2K3.42068282
5NME23.38854349
6TRIB33.20602326
7SIK13.14366541
8CDK123.05087281
9MAPKAPK33.05078505
10MARK12.82089510
11MAP3K32.77997468
12RIPK42.69502713
13MST1R2.42056295
14FER2.41240386
15KSR22.37962355
16MAP3K122.26075650
17MINK12.24136674
18MST42.18776945
19EPHA22.10200050
20ICK2.06905897
21NME11.95702107
22NTRK11.93328237
23NTRK31.90992144
24ERBB31.75913995
25LATS21.74466225
26TESK11.69149120
27TLK11.66547920
28ERN11.65142595
29MATK1.52978907
30PAK61.50124406
31IRAK31.46374405
32PBK1.42830194
33GRK51.42499538
34PRPF4B1.39634020
35TAOK11.37911567
36LIMK11.36530584
37MAPK151.33473062
38MAP3K11.32724941
39MET1.30770464
40RIPK11.30473951
41TBK11.25597646
42NEK61.21711654
43NTRK21.20758220
44EIF2AK11.15970711
45DYRK21.13379913
46MAP2K11.11067411
47PKN21.10197964
48EPHB11.05045449
49MAP2K41.04882132
50MAP3K111.00209603
51DAPK20.99910135
52CDK70.98260514
53VRK20.96853180
54MAP3K140.95019666
55PIM20.93542291
56MTOR0.93521416
57AURKA0.91274677
58RPS6KA20.91225240
59CDK50.91212762
60TRPM70.88984402
61RPS6KB20.86941467
62FGFR40.86848867
63MAPK110.86734923
64SCYL20.84025796
65TTK0.83995018
66CASK0.83392912
67RET0.81809136
68LRRK20.80741083
69PAK30.80545931
70EPHA30.76766392
71TESK20.74964497
72PTK60.74493415
73PAK40.73768863
74DYRK1B0.73514183
75PTK20.73141152
76AURKB0.69816411
77FGFR30.69054154
78MAP2K20.68901918
79PHKG10.68489352
80PHKG20.68489352
81CSNK1G20.67965230
82CAMKK10.67008095
83GRK60.66930081
84STK38L0.66562979
85MAP3K40.65200882
86BCR0.63915596
87MAPK130.63906920
88ILK0.61890266
89BLK0.61711173
90BRSK10.61369795
91PRKCZ0.60756013
92CHEK20.60506699
93IKBKB0.59235188
94AKT20.59203561
95PRKCG0.59160326
96EPHB20.58116055
97RPS6KA10.57231155
98ARAF0.57115547
99PRKD20.56433483
100LMTK20.56419696
101CDK80.56156330
102TAOK20.56127065
103CDK140.55890902
104CDK40.54882247
105FGR0.54190383
106PRKCE0.52973663
107MARK20.52527114
108PLK20.52463748
109KSR10.52262399
110ADRBK10.50515626
111BMX0.49810785
112UHMK10.49628848
113STK380.49393344
114MELK0.48743092
115ABL20.48551594
116BUB10.48445037
117MAP3K50.47980840
118CHUK0.45829441
119STK160.45554422
120MAP2K60.45507426
121CHEK10.44719813
122TYRO30.44519663
123MAP3K80.41972831
124DMPK0.41357397
125PRKD30.41042330
126WEE10.40298583
127TSSK60.39299272
128CAMKK20.39266044
129MAPK120.38536444
130PRKCI0.38501848
131NEK10.38374104
132MAPKAPK20.38076633
133CSNK1G30.37911720
134JAK20.37782049
135MAPK40.37581976
136SIK20.37417520
137MUSK0.37038810
138ERBB40.36964520
139PDK30.36506467
140PDK40.36506467
141SIK30.35495936
142FYN0.35188913
143PDPK10.34781762
144TNK20.34267575
145STK240.34262442
146HIPK20.34247250
147MAPKAPK50.34101257
148WNK30.33959035
149PRKCD0.33922570
150CAMK2G0.33577583
151SRC0.33101669
152PDK20.32160914
153IRAK20.32129392
154CDC42BPA0.31574887
155RPS6KA50.31376446
156LATS10.31204919
157CDK90.29380379
158MAP3K60.29283670
159ZAK0.26913880
160BCKDK0.26804133

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.27429498
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07820586
3Sulfur relay system_Homo sapiens_hsa041222.89442344
4Collecting duct acid secretion_Homo sapiens_hsa049662.82036042
5DNA replication_Homo sapiens_hsa030302.58987013
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58275960
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47133445
8Biosynthesis of amino acids_Homo sapiens_hsa012302.43568969
9Fructose and mannose metabolism_Homo sapiens_hsa000512.37130334
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28209103
11Pentose phosphate pathway_Homo sapiens_hsa000302.04248232
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.02910684
13Central carbon metabolism in cancer_Homo sapiens_hsa052302.00900933
14Vibrio cholerae infection_Homo sapiens_hsa051101.90606358
15Arginine biosynthesis_Homo sapiens_hsa002201.88602897
16Pancreatic secretion_Homo sapiens_hsa049721.86223914
17Sphingolipid metabolism_Homo sapiens_hsa006001.84492001
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81959687
19Base excision repair_Homo sapiens_hsa034101.78920508
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72792994
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69944533
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.66413339
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.62660345
24Lysosome_Homo sapiens_hsa041421.62216481
25Tyrosine metabolism_Homo sapiens_hsa003501.62085513
26Spliceosome_Homo sapiens_hsa030401.57531695
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51356138
28Galactose metabolism_Homo sapiens_hsa000521.50422224
29Phagosome_Homo sapiens_hsa041451.48463876
30VEGF signaling pathway_Homo sapiens_hsa043701.44332752
31Small cell lung cancer_Homo sapiens_hsa052221.40997055
32Dorso-ventral axis formation_Homo sapiens_hsa043201.38997047
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38574715
34Notch signaling pathway_Homo sapiens_hsa043301.37048667
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36786527
36Rheumatoid arthritis_Homo sapiens_hsa053231.35958379
37p53 signaling pathway_Homo sapiens_hsa041151.34522919
38Vitamin B6 metabolism_Homo sapiens_hsa007501.32232554
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29682845
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27304412
41Tuberculosis_Homo sapiens_hsa051521.25047624
42Sphingolipid signaling pathway_Homo sapiens_hsa040711.23302097
43Mineral absorption_Homo sapiens_hsa049781.22229935
44Nucleotide excision repair_Homo sapiens_hsa034201.20364250
45Carbon metabolism_Homo sapiens_hsa012001.19529088
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19137658
47Long-term potentiation_Homo sapiens_hsa047201.18859021
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.17987375
49GnRH signaling pathway_Homo sapiens_hsa049121.16266612
50Mismatch repair_Homo sapiens_hsa034301.12786966
51Salmonella infection_Homo sapiens_hsa051321.12091076
52Pyrimidine metabolism_Homo sapiens_hsa002401.11960192
53Pancreatic cancer_Homo sapiens_hsa052121.10875639
54RNA transport_Homo sapiens_hsa030131.08379802
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05078712
56Gastric acid secretion_Homo sapiens_hsa049711.04797948
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04293877
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03625314
59Olfactory transduction_Homo sapiens_hsa047401.03231788
60Cell cycle_Homo sapiens_hsa041101.02553100
61Dopaminergic synapse_Homo sapiens_hsa047281.02139864
62Serotonergic synapse_Homo sapiens_hsa047261.01668997
63N-Glycan biosynthesis_Homo sapiens_hsa005101.00841532
64Folate biosynthesis_Homo sapiens_hsa007900.99354775
65Axon guidance_Homo sapiens_hsa043600.98405630
66Estrogen signaling pathway_Homo sapiens_hsa049150.98249940
67Salivary secretion_Homo sapiens_hsa049700.97825504
68Endocytosis_Homo sapiens_hsa041440.96735363
69Non-small cell lung cancer_Homo sapiens_hsa052230.96330356
70Pyruvate metabolism_Homo sapiens_hsa006200.95074198
71Insulin secretion_Homo sapiens_hsa049110.94368177
72Glutathione metabolism_Homo sapiens_hsa004800.93331091
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92626269
74ErbB signaling pathway_Homo sapiens_hsa040120.92483508
75Long-term depression_Homo sapiens_hsa047300.92144058
76Protein digestion and absorption_Homo sapiens_hsa049740.91767462
77Leishmaniasis_Homo sapiens_hsa051400.91444842
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91286097
79Glioma_Homo sapiens_hsa052140.90908492
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89987310
81Chronic myeloid leukemia_Homo sapiens_hsa052200.89824873
82Amoebiasis_Homo sapiens_hsa051460.89592926
83Renin secretion_Homo sapiens_hsa049240.89264795
84Acute myeloid leukemia_Homo sapiens_hsa052210.87207879
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86971299
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83592537
87Pertussis_Homo sapiens_hsa051330.83037954
88Cholinergic synapse_Homo sapiens_hsa047250.82751187
89Endometrial cancer_Homo sapiens_hsa052130.82634946
90Influenza A_Homo sapiens_hsa051640.82011636
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.81822042
92Osteoclast differentiation_Homo sapiens_hsa043800.80998601
93Bladder cancer_Homo sapiens_hsa052190.80491007
94Melanogenesis_Homo sapiens_hsa049160.79215980
95Glutamatergic synapse_Homo sapiens_hsa047240.79207576
96Epstein-Barr virus infection_Homo sapiens_hsa051690.78847044
97Gap junction_Homo sapiens_hsa045400.77965713
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77567860
99Basal cell carcinoma_Homo sapiens_hsa052170.77548822
100Viral carcinogenesis_Homo sapiens_hsa052030.76933709
101Circadian entrainment_Homo sapiens_hsa047130.76706608
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75939774
103Glycerolipid metabolism_Homo sapiens_hsa005610.75734810
104Fat digestion and absorption_Homo sapiens_hsa049750.75581152
105Systemic lupus erythematosus_Homo sapiens_hsa053220.75487309
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75474539
107Nicotine addiction_Homo sapiens_hsa050330.74805195
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74607876
109Fatty acid biosynthesis_Homo sapiens_hsa000610.72735689
110B cell receptor signaling pathway_Homo sapiens_hsa046620.71330337
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71218809
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71139580
113Amphetamine addiction_Homo sapiens_hsa050310.71050732
114Legionellosis_Homo sapiens_hsa051340.70938005
115Insulin signaling pathway_Homo sapiens_hsa049100.70618604
116mRNA surveillance pathway_Homo sapiens_hsa030150.69928372
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69882367
118Taste transduction_Homo sapiens_hsa047420.69693611
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.69633291
120Toxoplasmosis_Homo sapiens_hsa051450.68596339
121Prolactin signaling pathway_Homo sapiens_hsa049170.68431846
122Hippo signaling pathway_Homo sapiens_hsa043900.68373749
123GABAergic synapse_Homo sapiens_hsa047270.68271034
124Choline metabolism in cancer_Homo sapiens_hsa052310.67743057
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67358741
126Renin-angiotensin system_Homo sapiens_hsa046140.66814038
127Ovarian steroidogenesis_Homo sapiens_hsa049130.66809685
128HTLV-I infection_Homo sapiens_hsa051660.66271583
129Shigellosis_Homo sapiens_hsa051310.66255097
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.65917716
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65656713
132Type II diabetes mellitus_Homo sapiens_hsa049300.64008760
133Oxytocin signaling pathway_Homo sapiens_hsa049210.63106324
134Arginine and proline metabolism_Homo sapiens_hsa003300.62847174
135Hepatitis C_Homo sapiens_hsa051600.62735570
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62535084
137Rap1 signaling pathway_Homo sapiens_hsa040150.61929551
138Renal cell carcinoma_Homo sapiens_hsa052110.61423803
139TNF signaling pathway_Homo sapiens_hsa046680.60216220
140Huntingtons disease_Homo sapiens_hsa050160.60122290
141Tight junction_Homo sapiens_hsa045300.59072997
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58613111
143Calcium signaling pathway_Homo sapiens_hsa040200.58366122
144Histidine metabolism_Homo sapiens_hsa003400.58251283
145Proteoglycans in cancer_Homo sapiens_hsa052050.57878738
146Phenylalanine metabolism_Homo sapiens_hsa003600.57663926
147Herpes simplex infection_Homo sapiens_hsa051680.57390166
148Ras signaling pathway_Homo sapiens_hsa040140.57347818
149Lysine degradation_Homo sapiens_hsa003100.57294647
150Ether lipid metabolism_Homo sapiens_hsa005650.56817157
151MicroRNAs in cancer_Homo sapiens_hsa052060.56440779
152AMPK signaling pathway_Homo sapiens_hsa041520.55509765
153Cocaine addiction_Homo sapiens_hsa050300.55500086
154Prostate cancer_Homo sapiens_hsa052150.55494261
155Melanoma_Homo sapiens_hsa052180.55310590
156Thyroid cancer_Homo sapiens_hsa052160.54792537
157MAPK signaling pathway_Homo sapiens_hsa040100.54388176
158Linoleic acid metabolism_Homo sapiens_hsa005910.54198285
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53455559
160Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52725064
161One carbon pool by folate_Homo sapiens_hsa006700.52224999
162Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51766746
163mTOR signaling pathway_Homo sapiens_hsa041500.51632529
164Apoptosis_Homo sapiens_hsa042100.50658597
165Hedgehog signaling pathway_Homo sapiens_hsa043400.50242535
166Cysteine and methionine metabolism_Homo sapiens_hsa002700.48712361
167Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45470396
168Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44235305
169HIF-1 signaling pathway_Homo sapiens_hsa040660.42954804
170Alcoholism_Homo sapiens_hsa050340.41030210
171Intestinal immune network for IgA production_Homo sapiens_hsa046720.38576098
172beta-Alanine metabolism_Homo sapiens_hsa004100.38235036
173Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36947647
174Inositol phosphate metabolism_Homo sapiens_hsa005620.35969799
175Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35959984
176RNA polymerase_Homo sapiens_hsa030200.35505233
177Insulin resistance_Homo sapiens_hsa049310.35499458
178ABC transporters_Homo sapiens_hsa020100.33227727
179Drug metabolism - other enzymes_Homo sapiens_hsa009830.32810853

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