RHOQP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)8.88507432
2regulation of acrosome reaction (GO:0060046)7.28787643
3acrosome reaction (GO:0007340)6.22268358
4protein K11-linked deubiquitination (GO:0035871)6.05573464
5regulation of DNA endoreduplication (GO:0032875)5.89968098
6adaptation of signaling pathway (GO:0023058)4.98311555
7resolution of meiotic recombination intermediates (GO:0000712)4.96397894
8oogenesis (GO:0048477)4.81297412
9chromosome organization involved in meiosis (GO:0070192)4.72702507
10protein targeting to Golgi (GO:0000042)4.72389801
11establishment of protein localization to Golgi (GO:0072600)4.62422676
12male meiosis I (GO:0007141)4.62397479
13prostate gland growth (GO:0060736)4.47776022
14negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.22737502
15retrograde transport, vesicle recycling within Golgi (GO:0000301)4.18301770
16negative regulation of DNA-dependent DNA replication (GO:2000104)4.06298498
17phosphate ion homeostasis (GO:0055062)4.02403692
18trivalent inorganic anion homeostasis (GO:0072506)4.02403692
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.98500120
20sister chromatid cohesion (GO:0007062)3.97914883
21female gamete generation (GO:0007292)3.97839759
22ether lipid metabolic process (GO:0046485)3.93931670
23tachykinin receptor signaling pathway (GO:0007217)3.92963321
24regulation of DNA damage checkpoint (GO:2000001)3.83742442
25nuclear pore organization (GO:0006999)3.72144014
26regulation of somitogenesis (GO:0014807)3.70892547
27protein localization to Golgi apparatus (GO:0034067)3.57088388
28positive regulation of neurotransmitter secretion (GO:0001956)3.55857239
29regulation of skeletal muscle contraction (GO:0014819)3.55602478
30sulfation (GO:0051923)3.54891344
31pore complex assembly (GO:0046931)3.54234673
32replicative senescence (GO:0090399)3.51532255
33regulation of meiosis I (GO:0060631)3.47077139
34negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.45454974
35adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.42556027
36synaptonemal complex organization (GO:0070193)3.42082731
37piRNA metabolic process (GO:0034587)3.41747437
38viral mRNA export from host cell nucleus (GO:0046784)3.39060477
39positive regulation of vascular permeability (GO:0043117)3.37571585
40regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.37062312
41regulation of sequestering of triglyceride (GO:0010889)3.34574446
42adrenergic receptor signaling pathway (GO:0071875)3.34344638
43oocyte maturation (GO:0001556)3.30087712
44attachment of spindle microtubules to kinetochore (GO:0008608)3.29747492
45histone H3-K36 demethylation (GO:0070544)3.29619323
46DNA synthesis involved in DNA repair (GO:0000731)3.25021169
47cellular anion homeostasis (GO:0030002)3.23623858
48response to epinephrine (GO:0071871)3.23587793
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20552369
50detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.19301308
51prenylation (GO:0097354)3.15272009
52protein prenylation (GO:0018342)3.15272009
53meiosis I (GO:0007127)3.15182825
54synaptonemal complex assembly (GO:0007130)3.13029197
55potassium ion homeostasis (GO:0055075)3.12241982
56metaphase plate congression (GO:0051310)3.10613680
57nuclear pore complex assembly (GO:0051292)3.07885393
58negative regulation of systemic arterial blood pressure (GO:0003085)3.03658466
59calcium ion-dependent exocytosis (GO:0017156)3.03062715
60positive regulation of uterine smooth muscle contraction (GO:0070474)3.02096252
61phosphatidylcholine biosynthetic process (GO:0006656)3.00949553
62negative regulation of smooth muscle contraction (GO:0045986)2.98687348
63collecting duct development (GO:0072044)2.97412043
64transepithelial transport (GO:0070633)2.93676818
65retina layer formation (GO:0010842)2.92742090
66histone ubiquitination (GO:0016574)2.92632170
67interferon-gamma production (GO:0032609)2.91258586
68protein K48-linked deubiquitination (GO:0071108)2.90338667
69histone H3-K9 demethylation (GO:0033169)2.89782242
70cellular response to epinephrine stimulus (GO:0071872)2.89159519
71oligosaccharide catabolic process (GO:0009313)2.87911211
72male meiosis (GO:0007140)2.87064959
73histone monoubiquitination (GO:0010390)2.82684839
74positive regulation of developmental pigmentation (GO:0048087)2.82650642
75cAMP biosynthetic process (GO:0006171)2.82537113
76detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.82238761
77regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.81994342
78magnesium ion transport (GO:0015693)2.79127038
79negative regulation of multicellular organism growth (GO:0040015)2.77948059
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77809873
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77809873
82positive regulation of mitotic sister chromatid separation (GO:1901970)2.77809873
83positive regulation of urine volume (GO:0035810)2.77703552
84aorta morphogenesis (GO:0035909)2.77624506
85positive regulation of response to oxidative stress (GO:1902884)2.75647626
86positive regulation of cellular response to oxidative stress (GO:1900409)2.75647626
87regulation of gonadotropin secretion (GO:0032276)2.73309236
88positive regulation of meiosis (GO:0045836)2.72408628
89activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.71991024
90cell fate commitment involved in formation of primary germ layer (GO:0060795)2.69283755
91opsonization (GO:0008228)2.67259311
92regulation of establishment of cell polarity (GO:2000114)2.66268787
93meiotic cell cycle process (GO:1903046)2.63704744
94negative regulation of DNA recombination (GO:0045910)2.63669960
95mitotic sister chromatid cohesion (GO:0007064)2.61424952
96cerebellar granule cell differentiation (GO:0021707)2.61393744
97otic vesicle formation (GO:0030916)2.61268417
98nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.60033169
99regulation of protein glycosylation (GO:0060049)2.59637112
100telomere maintenance via telomerase (GO:0007004)2.58177217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.52357150
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25453348
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60167534
4GBX2_23144817_ChIP-Seq_PC3_Human2.58508799
5IGF1R_20145208_ChIP-Seq_DFB_Human2.57388619
6TAF15_26573619_Chip-Seq_HEK293_Human2.56149708
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.54354231
8EWS_26573619_Chip-Seq_HEK293_Human2.48060094
9GATA1_22025678_ChIP-Seq_K562_Human2.33868825
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.32083072
11FUS_26573619_Chip-Seq_HEK293_Human2.31125813
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16804616
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.14327516
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11143448
15P300_19829295_ChIP-Seq_ESCs_Human2.03549697
16BCAT_22108803_ChIP-Seq_LS180_Human1.95295435
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.87554340
18CBP_20019798_ChIP-Seq_JUKART_Human1.87554340
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.87434412
20TOP2B_26459242_ChIP-Seq_MCF-7_Human1.86504004
21AR_21572438_ChIP-Seq_LNCaP_Human1.82455304
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79795325
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78083450
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.77337700
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76862200
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.74741577
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74683252
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71766586
29RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.67573301
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66862840
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60950826
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60871264
33PRDM14_20953172_ChIP-Seq_ESCs_Human1.59142389
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58408517
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.50844359
36SMAD4_21799915_ChIP-Seq_A2780_Human1.49697702
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49451022
38TP53_16413492_ChIP-PET_HCT116_Human1.49056735
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.48131691
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45218140
41EZH2_22144423_ChIP-Seq_EOC_Human1.44685198
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43273173
43RNF2_27304074_Chip-Seq_NSC_Mouse1.43246931
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42936839
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42705568
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.39498846
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.38169646
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36392330
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36280261
50CDX2_22108803_ChIP-Seq_LS180_Human1.35967904
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34326380
52ER_23166858_ChIP-Seq_MCF-7_Human1.34125266
53FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33699633
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32990410
55RUNX_20019798_ChIP-Seq_JUKART_Human1.32097968
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30931210
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30772594
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30074378
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29406445
60TCF4_23295773_ChIP-Seq_U87_Human1.28841791
61AHR_22903824_ChIP-Seq_MCF-7_Human1.28276553
62KDM2B_26808549_Chip-Seq_REH_Human1.25852608
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.23674052
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23274651
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.20162154
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.18384553
67IRF1_19129219_ChIP-ChIP_H3396_Human1.17833052
68CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16850473
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16572393
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16202018
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15166161
72STAT3_23295773_ChIP-Seq_U87_Human1.15143355
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14851992
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13720909
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.13189013
76NANOG_19829295_ChIP-Seq_ESCs_Human1.12977429
77SOX2_19829295_ChIP-Seq_ESCs_Human1.12977429
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12838608
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12708346
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.11155242
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.10975265
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10059842
83AR_25329375_ChIP-Seq_VCAP_Human1.09971584
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09292349
85RXR_22108803_ChIP-Seq_LS180_Human1.08945009
86TCF4_22108803_ChIP-Seq_LS180_Human1.07882233
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07752889
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.06678181
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.05869894
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.05486242
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05159143
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04204905
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03682818
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02264014
95GATA3_27048872_Chip-Seq_THYMUS_Human1.01786211
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.99259918
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.98483471
98TP63_23658742_ChIP-Seq_EP156T_Human0.98468342
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98446511
100RUNX2_22187159_ChIP-Seq_PCA_Human0.97961409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism7.25424978
2MP0002163_abnormal_gland_morphology5.45604756
3MP0002009_preneoplasia4.77720528
4MP0002160_abnormal_reproductive_system4.30297618
5MP0005379_endocrine/exocrine_gland_phen3.95785947
6MP0002166_altered_tumor_susceptibility3.09805278
7MP0008877_abnormal_DNA_methylation2.98394215
8MP0003656_abnormal_erythrocyte_physiolo2.63469971
9MP0005389_reproductive_system_phenotype2.59703913
10MP0002006_tumorigenesis2.51090790
11MP0004381_abnormal_hair_follicle2.39207504
12MP0000613_abnormal_salivary_gland2.19343991
13MP0000372_irregular_coat_pigmentation2.16238615
14MP0005410_abnormal_fertilization1.88062867
15MP0002132_abnormal_respiratory_system1.82111713
16MP0001542_abnormal_bone_strength1.81906387
17MP0005220_abnormal_exocrine_pancreas1.77398827
18MP0004084_abnormal_cardiac_muscle1.71933295
19MP0005423_abnormal_somatic_nervous1.66630513
20MP0009780_abnormal_chondrocyte_physiolo1.65049217
21MP0001661_extended_life_span1.60814430
22MP0005075_abnormal_melanosome_morpholog1.57809348
23MP0001177_atelectasis1.56053547
24MP0006292_abnormal_olfactory_placode1.49610167
25MP0000427_abnormal_hair_cycle1.48229513
26MP0003950_abnormal_plasma_membrane1.41885904
27MP0004885_abnormal_endolymph1.39286198
28MP0002210_abnormal_sex_determination1.36813103
29MP0001929_abnormal_gametogenesis1.36068851
30MP0002396_abnormal_hematopoietic_system1.31439084
31MP0003693_abnormal_embryo_hatching1.29978209
32MP0002735_abnormal_chemical_nociception1.28185221
33MP0003221_abnormal_cardiomyocyte_apopto1.27897486
34MP0005275_abnormal_skin_tensile1.26386163
35MP0000015_abnormal_ear_pigmentation1.25024032
36MP0004484_altered_response_of1.24188742
37MP0001440_abnormal_grooming_behavior1.23583852
38MP0002277_abnormal_respiratory_mucosa1.18844099
39MP0000653_abnormal_sex_gland1.17669785
40MP0001145_abnormal_male_reproductive1.17660088
41MP0004215_abnormal_myocardial_fiber1.16332997
42MP0005670_abnormal_white_adipose1.15312910
43MP0003959_abnormal_lean_body1.14048447
44MP0000569_abnormal_digit_pigmentation1.12035486
45MP0006072_abnormal_retinal_apoptosis1.11090541
46MP0003698_abnormal_male_reproductive1.09032497
47MP0006276_abnormal_autonomic_nervous1.06822153
48MP0001879_abnormal_lymphatic_vessel1.06804161
49MP0002332_abnormal_exercise_endurance1.04217563
50MP0005646_abnormal_pituitary_gland1.03013482
51MP0000749_muscle_degeneration1.01269489
52MP0008057_abnormal_DNA_replication1.01160801
53MP0009697_abnormal_copulation1.00321225
54MP0002090_abnormal_vision0.98250786
55MP0001119_abnormal_female_reproductive0.95402904
56MP0004085_abnormal_heartbeat0.93857184
57MP0002254_reproductive_system_inflammat0.91876180
58MP0001348_abnormal_lacrimal_gland0.90800018
59MP0005464_abnormal_platelet_physiology0.90458805
60MP0001666_abnormal_nutrient_absorption0.89641684
61MP0006054_spinal_hemorrhage0.86698828
62MP0005171_absent_coat_pigmentation0.85288230
63MP0008872_abnormal_physiological_respon0.84137738
64MP0003763_abnormal_thymus_physiology0.83445670
65MP0003724_increased_susceptibility_to0.82517351
66MP0000750_abnormal_muscle_regeneration0.81513507
67MP0005083_abnormal_biliary_tract0.78026316
68MP0002282_abnormal_trachea_morphology0.77439630
69MP0003890_abnormal_embryonic-extraembry0.75234442
70MP0003718_maternal_effect0.75082293
71MP0003646_muscle_fatigue0.74573037
72MP0005360_urolithiasis0.74350198
73MP0002876_abnormal_thyroid_physiology0.73864066
74MP0000462_abnormal_digestive_system0.71370826
75MP0009764_decreased_sensitivity_to0.70812473
76MP0003121_genomic_imprinting0.70677541
77MP0000767_abnormal_smooth_muscle0.70603712
78MP0005551_abnormal_eye_electrophysiolog0.68873640
79MP0001919_abnormal_reproductive_system0.67068760
80MP0003279_aneurysm0.66730886
81MP0001984_abnormal_olfaction0.66038501
82MP0002108_abnormal_muscle_morphology0.65370962
83MP0002127_abnormal_cardiovascular_syste0.63827220
84MP0003252_abnormal_bile_duct0.63291291
85MP0004883_abnormal_blood_vessel0.63236274
86MP0001986_abnormal_taste_sensitivity0.62209026
87MP0001800_abnormal_humoral_immune0.62165621
88MP0010368_abnormal_lymphatic_system0.62087945
89MP0000358_abnormal_cell_content/0.61678683
90MP0004036_abnormal_muscle_relaxation0.61421820
91MP0001835_abnormal_antigen_presentation0.60797407
92MP0002272_abnormal_nervous_system0.55757895
93MP0004142_abnormal_muscle_tone0.55262515
94MP0005330_cardiomyopathy0.54136198
95MP0003448_altered_tumor_morphology0.53951296
96MP0002138_abnormal_hepatobiliary_system0.53072744
97MP0004510_myositis0.52190046
98MP0008873_increased_physiological_sensi0.50992221
99MP0003936_abnormal_reproductive_system0.50671282
100MP0003868_abnormal_feces_composition0.49775398

Predicted human phenotypes

RankGene SetZ-score
1Diastasis recti (HP:0001540)5.49661623
2Carpal bone hypoplasia (HP:0001498)4.94403985
3Recurrent bronchitis (HP:0002837)4.49114226
4Aplasia of the musculature (HP:0100854)4.48599342
5Spontaneous abortion (HP:0005268)4.48120190
6Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.37760647
7J-shaped sella turcica (HP:0002680)4.18471141
8Chronic sinusitis (HP:0011109)4.14646513
9Visual hallucinations (HP:0002367)4.11220609
10Symphalangism affecting the phalanges of the hand (HP:0009773)4.09029461
11Myelomeningocele (HP:0002475)4.08547945
12Abnormality of the lumbar spine (HP:0100712)3.99658628
13Papilledema (HP:0001085)3.67385586
14Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.38227211
15Oligodactyly (hands) (HP:0001180)3.33346531
16Amniotic constriction ring (HP:0009775)3.33313356
17Abnormality of placental membranes (HP:0011409)3.33313356
18Broad ribs (HP:0000885)3.28299753
19Slow saccadic eye movements (HP:0000514)3.19593173
20Azoospermia (HP:0000027)3.15834778
21Thoracolumbar scoliosis (HP:0002944)3.12974380
22T lymphocytopenia (HP:0005403)3.12898339
23Vertebral arch anomaly (HP:0008438)3.10892478
24Hypoplastic pelvis (HP:0008839)3.09677309
25Abnormality of the phalanges of the 5th finger (HP:0004213)3.03275121
26Aplasia/Hypoplasia involving the musculature (HP:0001460)3.02402194
27Broad alveolar ridges (HP:0000187)2.97741025
28Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.94916936
29B lymphocytopenia (HP:0010976)2.73969321
30Abolished electroretinogram (ERG) (HP:0000550)2.73853358
31Hypoplastic scapulae (HP:0000882)2.73725137
32Aplasia/Hypoplasia of the scapulae (HP:0006713)2.73725137
33Recurrent pneumonia (HP:0006532)2.73337249
34Albinism (HP:0001022)2.70372700
35Abnormal spermatogenesis (HP:0008669)2.69001560
36Abnormality of T cell number (HP:0011839)2.68525279
37Abnormality of the epiphyses of the hand (HP:0005924)2.65646957
38Anomalous pulmonary venous return (HP:0010772)2.61925082
39Hypoplastic nipples (HP:0002557)2.61810367
40Protuberant abdomen (HP:0001538)2.60003791
41Abnormality of the odontoid process (HP:0003310)2.57467272
42Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.57347180
43Abnormality of glycolipid metabolism (HP:0010969)2.56654055
44Abnormality of liposaccharide metabolism (HP:0010968)2.56654055
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.56654055
46Bronchitis (HP:0012387)2.55802883
47Pancreatic cysts (HP:0001737)2.54473044
48Abnormal pancreas size (HP:0012094)2.50116680
49Volvulus (HP:0002580)2.47113269
50Microcytic anemia (HP:0001935)2.46716152
51Abnormality of B cell number (HP:0010975)2.37760679
52Neonatal respiratory distress (HP:0002643)2.31986324
53Abnormality of the pulmonary veins (HP:0011718)2.29710519
54Popliteal pterygium (HP:0009756)2.29126571
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.24100378
56Long clavicles (HP:0000890)2.20553227
57Abnormality of the sella turcica (HP:0002679)2.19135063
58Duplicated collecting system (HP:0000081)2.17816872
59Cavernous hemangioma (HP:0001048)2.16777649
60Thyroiditis (HP:0100646)2.15376179
61Focal motor seizures (HP:0011153)2.15354900
62Aortic regurgitation (HP:0001659)2.14622932
63Acute hepatic failure (HP:0006554)2.08158442
64Abnormality of the renal collecting system (HP:0004742)2.07202321
65Aplasia/Hypoplasia of the clavicles (HP:0006710)2.05932145
66Meningocele (HP:0002435)2.05127120
67Deformed sella turcica (HP:0002681)2.04322262
68Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.03267740
69Short clavicles (HP:0000894)2.01983084
70Hypochromic microcytic anemia (HP:0004840)2.01551900
71Split foot (HP:0001839)1.99209135
72Ankyloglossia (HP:0010296)1.95933876
73Flat acetabular roof (HP:0003180)1.95703264
74Agnosia (HP:0010524)1.95598922
75Choroideremia (HP:0001139)1.94781483
76Capillary hemangiomas (HP:0005306)1.94382208
77Supernumerary nipples (HP:0002558)1.90297362
78Pulmonary artery stenosis (HP:0004415)1.87986803
79Oligodactyly (HP:0012165)1.85573754
80Hypoplasia of the thymus (HP:0000778)1.85246108
81Oral leukoplakia (HP:0002745)1.83547282
82Thoracic kyphosis (HP:0002942)1.82986118
83Fatigue (HP:0012378)1.82453516
84Abnormality of chloride homeostasis (HP:0011422)1.82233834
85Tongue fasciculations (HP:0001308)1.79594914
86Periauricular skin pits (HP:0100277)1.77964895
87Preauricular pit (HP:0004467)1.77964895
88Abnormality of the right ventricle (HP:0001707)1.74272155
89Hypoplasia of the odontoid process (HP:0003311)1.74078925
90Widely spaced teeth (HP:0000687)1.73218079
91Short ribs (HP:0000773)1.73009360
92Abnormality of the alveolar ridges (HP:0006477)1.71133287
93Ureteral duplication (HP:0000073)1.67946489
94Broad nasal tip (HP:0000455)1.67854112
95Exocrine pancreatic insufficiency (HP:0001738)1.67514277
96Slender build (HP:0001533)1.66574459
97Prominent occiput (HP:0000269)1.65488536
98Concave nail (HP:0001598)1.65204367
99Akinesia (HP:0002304)1.64709779
100Recurrent lower respiratory tract infections (HP:0002783)1.64320729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK75.13069059
2TGFBR24.94449316
3BLK4.36088695
4EIF2AK33.42595369
5GRK53.21239201
6MOS2.98763735
7LMTK22.86869590
8ACVR1B2.83897567
9PAK32.65924836
10FRK2.52013179
11STK102.30380129
12PLK21.98066566
13MAP4K21.97888081
14FER1.87067253
15MST41.82371447
16NEK91.80348877
17PRKCI1.65930923
18IRAK21.64096517
19EIF2AK21.49161543
20MAP3K121.43729326
21TEC1.34550552
22WNK11.30638486
23MAP3K61.26040451
24IRAK41.21616075
25MAP2K41.21418016
26MAP3K21.19426662
27STK241.18706403
28STK391.16652261
29ZAK1.15916451
30IKBKE1.15719255
31ERBB31.10583652
32ADRBK11.09397676
33SYK1.07079587
34PNCK1.05045528
35BMPR21.00698934
36OXSR10.97594751
37TAF10.95171367
38STK30.94653501
39MAP2K10.92089693
40TXK0.90621484
41PTK20.88793906
42PLK40.88019499
43MAP3K40.86985404
44MATK0.86464812
45IRAK10.83029916
46MAP3K50.81963364
47AKT30.80439015
48CAMK40.77645945
49MKNK20.77423800
50MYLK0.75463687
51PINK10.74857169
52CAMKK20.74823382
53FLT30.72068499
54MAP3K110.71572863
55BRSK20.68902357
56PRKD10.66852628
57FGFR10.66775664
58TNIK0.65878103
59MELK0.62603130
60MAP2K30.61239266
61GRK60.60020396
62PTK2B0.56751975
63MAP2K60.53227038
64PLK30.50891364
65CAMK1G0.48051027
66PAK10.47680422
67GRK10.45143631
68JAK20.44343777
69PKN20.44317430
70MKNK10.43546929
71DMPK0.43519351
72PRKCQ0.43077549
73PRKG10.42816309
74IGF1R0.41891882
75MAP2K70.41607560
76INSRR0.41515368
77NUAK10.40569546
78SGK10.40125917
79WEE10.38804760
80GSK3A0.38112562
81PRKG20.37274412
82OBSCN0.36604594
83STK110.36086909
84KIT0.34027674
85DYRK1A0.34017545
86PIM10.33529036
87NEK60.33382666
88NLK0.33359223
89WNK40.33189256
90BMPR1B0.32797948
91MAPKAPK20.32764916
92STK40.32596882
93LYN0.32057668
94MAP4K10.31448063
95INSR0.31166090
96ITK0.30803992
97AKT20.30085955
98PDK10.29948193
99TRPM70.29092190
100CHEK20.28881047

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.56047121
2Caffeine metabolism_Homo sapiens_hsa002323.15149187
3Dorso-ventral axis formation_Homo sapiens_hsa043202.77826749
4Ether lipid metabolism_Homo sapiens_hsa005652.52606879
5Platelet activation_Homo sapiens_hsa046112.29572824
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.26480587
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.17026737
8Primary immunodeficiency_Homo sapiens_hsa053402.08922458
9Dilated cardiomyopathy_Homo sapiens_hsa054141.88858431
10ABC transporters_Homo sapiens_hsa020101.76150902
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68780769
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67002160
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55200727
14Basal transcription factors_Homo sapiens_hsa030221.54354970
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42827892
16Ovarian steroidogenesis_Homo sapiens_hsa049131.33271202
17Sphingolipid signaling pathway_Homo sapiens_hsa040711.31460953
18Oocyte meiosis_Homo sapiens_hsa041141.26124348
19Renin secretion_Homo sapiens_hsa049241.24128189
20B cell receptor signaling pathway_Homo sapiens_hsa046621.23850706
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22051552
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19922848
23cAMP signaling pathway_Homo sapiens_hsa040241.17164471
24Linoleic acid metabolism_Homo sapiens_hsa005911.14930086
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11468336
26Gastric acid secretion_Homo sapiens_hsa049711.11397958
27RNA transport_Homo sapiens_hsa030131.10684194
28Pancreatic secretion_Homo sapiens_hsa049721.09927462
29Cholinergic synapse_Homo sapiens_hsa047251.09100577
30Salivary secretion_Homo sapiens_hsa049701.06685848
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05691200
32Bile secretion_Homo sapiens_hsa049761.03563386
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01144786
34Phototransduction_Homo sapiens_hsa047441.00047211
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98990972
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97641829
37TGF-beta signaling pathway_Homo sapiens_hsa043500.92956067
38Taste transduction_Homo sapiens_hsa047420.92778422
39Osteoclast differentiation_Homo sapiens_hsa043800.92200867
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89995602
41Systemic lupus erythematosus_Homo sapiens_hsa053220.89437362
42Collecting duct acid secretion_Homo sapiens_hsa049660.89378456
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88955784
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.86002780
45Olfactory transduction_Homo sapiens_hsa047400.85720525
46Protein export_Homo sapiens_hsa030600.82324119
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79945196
48Circadian entrainment_Homo sapiens_hsa047130.79937835
49Chemical carcinogenesis_Homo sapiens_hsa052040.79186888
50Regulation of autophagy_Homo sapiens_hsa041400.79156766
51RNA degradation_Homo sapiens_hsa030180.77347302
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77008015
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74664432
54Small cell lung cancer_Homo sapiens_hsa052220.73504005
55Calcium signaling pathway_Homo sapiens_hsa040200.73289438
56Melanoma_Homo sapiens_hsa052180.73107532
57Mismatch repair_Homo sapiens_hsa034300.72372183
58p53 signaling pathway_Homo sapiens_hsa041150.72339297
59Oxytocin signaling pathway_Homo sapiens_hsa049210.70302284
60Sphingolipid metabolism_Homo sapiens_hsa006000.69177478
61Viral carcinogenesis_Homo sapiens_hsa052030.69155100
62Retinol metabolism_Homo sapiens_hsa008300.68296599
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67955494
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65033666
65Long-term depression_Homo sapiens_hsa047300.63498975
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.63458349
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.62017217
68Staphylococcus aureus infection_Homo sapiens_hsa051500.60300588
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60180397
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.59497167
71Glutamatergic synapse_Homo sapiens_hsa047240.58301308
72Type II diabetes mellitus_Homo sapiens_hsa049300.57498391
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57209333
74ECM-receptor interaction_Homo sapiens_hsa045120.57032434
75Cell cycle_Homo sapiens_hsa041100.56611628
76Hepatitis C_Homo sapiens_hsa051600.56017275
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54601058
78MAPK signaling pathway_Homo sapiens_hsa040100.53291598
79Leishmaniasis_Homo sapiens_hsa051400.52992953
80Choline metabolism in cancer_Homo sapiens_hsa052310.52983591
81Fanconi anemia pathway_Homo sapiens_hsa034600.51656337
82Propanoate metabolism_Homo sapiens_hsa006400.51532905
83Steroid biosynthesis_Homo sapiens_hsa001000.51363298
84Mineral absorption_Homo sapiens_hsa049780.49734719
85Morphine addiction_Homo sapiens_hsa050320.48933260
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.48576871
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48268831
88T cell receptor signaling pathway_Homo sapiens_hsa046600.47414494
89GABAergic synapse_Homo sapiens_hsa047270.45706628
90mTOR signaling pathway_Homo sapiens_hsa041500.45377473
91FoxO signaling pathway_Homo sapiens_hsa040680.44128183
92Arachidonic acid metabolism_Homo sapiens_hsa005900.43366308
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.43223061
94Sulfur relay system_Homo sapiens_hsa041220.40642076
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40310976
96Colorectal cancer_Homo sapiens_hsa052100.40124903
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39180298
98Gap junction_Homo sapiens_hsa045400.38999054
99GnRH signaling pathway_Homo sapiens_hsa049120.38119097
100Renal cell carcinoma_Homo sapiens_hsa052110.37616090

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