RHOJ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.98025021
2blood vessel maturation (GO:0001955)5.52228389
3protein heterotrimerization (GO:0070208)5.44556427
4vascular endothelial growth factor signaling pathway (GO:0038084)5.23041912
5collagen fibril organization (GO:0030199)4.90400143
6lymphangiogenesis (GO:0001946)4.66780831
7basement membrane organization (GO:0071711)4.43527912
8endothelium development (GO:0003158)4.38996172
9peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.20796359
10cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.18924294
11chondrocyte proliferation (GO:0035988)4.07635222
12endothelial cell morphogenesis (GO:0001886)4.06872980
13sequestering of extracellular ligand from receptor (GO:0035581)3.98452337
14extracellular fibril organization (GO:0043206)3.92949375
15glomerular filtration (GO:0003094)3.91122713
16* retina vasculature morphogenesis in camera-type eye (GO:0061299)3.90434822
17negative regulation of nitric-oxide synthase activity (GO:0051001)3.84848068
18dermatan sulfate biosynthetic process (GO:0030208)3.84141106
19keratan sulfate catabolic process (GO:0042340)3.84125704
20fibril organization (GO:0097435)3.77079215
21glomerular basement membrane development (GO:0032836)3.76228035
22ganglion development (GO:0061548)3.74857483
23cell adhesion mediated by integrin (GO:0033627)3.73892682
24wound healing, spreading of epidermal cells (GO:0035313)3.69605527
25bone trabecula formation (GO:0060346)3.69432926
26regulation of endothelial cell differentiation (GO:0045601)3.67344504
27renal filtration (GO:0097205)3.63169705
28cell migration involved in heart development (GO:0060973)3.57035421
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.53283903
30endodermal cell differentiation (GO:0035987)3.51097947
31dermatan sulfate metabolic process (GO:0030205)3.50975524
32collagen metabolic process (GO:0032963)3.49590973
33skin morphogenesis (GO:0043589)3.44713819
34vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.41918552
35collagen catabolic process (GO:0030574)3.34820804
36smooth muscle tissue development (GO:0048745)3.33246663
37multicellular organismal macromolecule metabolic process (GO:0044259)3.31657681
38extracellular matrix assembly (GO:0085029)3.29318166
39positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.23180745
40endothelial cell differentiation (GO:0045446)3.22917587
41trabecula formation (GO:0060343)3.22055435
42endothelial cell proliferation (GO:0001935)3.19957215
43positive regulation of vasculogenesis (GO:2001214)3.17597277
44substrate-dependent cell migration (GO:0006929)3.17443082
45Notch signaling involved in heart development (GO:0061314)3.17139896
46venous blood vessel morphogenesis (GO:0048845)3.16614162
47multicellular organismal metabolic process (GO:0044236)3.15198030
48morphogenesis of an endothelium (GO:0003159)3.14394791
49endothelial tube morphogenesis (GO:0061154)3.14394791
50multicellular organismal catabolic process (GO:0044243)3.12674810
51atrioventricular valve morphogenesis (GO:0003181)3.12504094
52neuron projection extension involved in neuron projection guidance (GO:1902284)3.11649177
53axon extension involved in axon guidance (GO:0048846)3.11649177
54extracellular matrix disassembly (GO:0022617)3.09839461
55regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.07784650
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.07592752
57ovulation from ovarian follicle (GO:0001542)3.07277647
58metanephric mesenchyme development (GO:0072075)3.07240639
59positive regulation of endothelial cell apoptotic process (GO:2000353)3.05633437
60artery development (GO:0060840)3.05510442
61regulation of axon extension involved in axon guidance (GO:0048841)3.03567526
62regulation of vasculogenesis (GO:2001212)3.02636631
63negative regulation of endothelial cell apoptotic process (GO:2000352)3.01149302
64negative regulation of blood vessel endothelial cell migration (GO:0043537)3.00426370
65positive regulation of epithelial to mesenchymal transition (GO:0010718)2.99567769
66negative regulation of protein localization to cell surface (GO:2000009)2.99490005
67heart trabecula formation (GO:0060347)2.98171348
68extracellular matrix organization (GO:0030198)2.97517837
69negative regulation of complement activation (GO:0045916)2.96433365
70extracellular structure organization (GO:0043062)2.96119414
71regulation of integrin-mediated signaling pathway (GO:2001044)2.95379579
72cell migration involved in sprouting angiogenesis (GO:0002042)2.95099065
73patterning of blood vessels (GO:0001569)2.92172717
74nephron epithelium development (GO:0072009)2.91574867
75endocardial cushion morphogenesis (GO:0003203)2.90784495
76regulation of chondrocyte differentiation (GO:0032330)2.90178313
77mesenchymal-epithelial cell signaling (GO:0060638)2.87998950
78positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.87430225
79blood vessel remodeling (GO:0001974)2.85816714
80negative regulation of endothelial cell migration (GO:0010596)2.83454490
81auditory behavior (GO:0031223)2.82628781
82sprouting angiogenesis (GO:0002040)2.82006912
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81847881
84positive regulation of urine volume (GO:0035810)2.81785269
85type B pancreatic cell proliferation (GO:0044342)2.81496834
86negative regulation of chondrocyte differentiation (GO:0032331)2.80883951
87kidney mesenchyme development (GO:0072074)2.80526755
88regulation of macrophage cytokine production (GO:0010935)2.79904242
89positive regulation of endothelial cell differentiation (GO:0045603)2.79541581
90vascular smooth muscle contraction (GO:0014829)2.78786253
91regulation of axon guidance (GO:1902667)2.78696233
92negative regulation of cartilage development (GO:0061037)2.78662287
93positive regulation of cartilage development (GO:0061036)2.77359269
94wound healing, spreading of cells (GO:0044319)2.76682046
95negative chemotaxis (GO:0050919)2.76304961
96cardiac epithelial to mesenchymal transition (GO:0060317)2.74870528
97negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.74504966
98response to fluid shear stress (GO:0034405)2.73617865
99platelet dense granule organization (GO:0060155)2.72020498
100positive regulation of endothelial cell migration (GO:0010595)2.71971211
101positive regulation of blood vessel endothelial cell migration (GO:0043536)2.71488959
102protein localization to cell surface (GO:0034394)2.71238160
103epithelial cell-cell adhesion (GO:0090136)2.71017408
104neuron remodeling (GO:0016322)2.70928196
105regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.70292850
106negative regulation of axon guidance (GO:1902668)2.68423439
107substrate adhesion-dependent cell spreading (GO:0034446)2.68326258
108presynaptic membrane assembly (GO:0097105)2.67404720
109regulation of penile erection (GO:0060405)2.67111638
110positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.66205336
111plasma membrane repair (GO:0001778)2.64809460
112apoptotic cell clearance (GO:0043277)2.64165800
113regulation of endothelial cell migration (GO:0010594)2.64107448
114blood vessel endothelial cell migration (GO:0043534)2.63607759
115regulation of establishment or maintenance of cell polarity (GO:0032878)2.63165075
116regulation of sarcomere organization (GO:0060297)2.62601926
117negative regulation of platelet activation (GO:0010544)2.61285937
118regulation of blood vessel endothelial cell migration (GO:0043535)2.59064542
119negative regulation of endothelial cell proliferation (GO:0001937)2.58921533
120regulation of cartilage development (GO:0061035)2.58820352
121protein targeting to plasma membrane (GO:0072661)2.58308916
122pathway-restricted SMAD protein phosphorylation (GO:0060389)2.57836253
123angiogenesis involved in wound healing (GO:0060055)2.57427491
124mesenchyme morphogenesis (GO:0072132)2.57426848
125definitive hemopoiesis (GO:0060216)2.57365078
126cell-matrix adhesion (GO:0007160)2.56813154
127regulation of tight junction assembly (GO:2000810)2.56565100
128regulation of chemokine-mediated signaling pathway (GO:0070099)2.56390028
129coronary vasculature morphogenesis (GO:0060977)2.55929781
130adhesion of symbiont to host (GO:0044406)2.55614749
131lung lobe morphogenesis (GO:0060463)2.55167619
132regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.54289242
133vasculogenesis (GO:0001570)2.53896670
134epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.53661634
135glomerulus development (GO:0032835)2.53621099
136positive regulation of chondrocyte differentiation (GO:0032332)2.51933959
137embryonic heart tube development (GO:0035050)2.50527407
138neural crest cell development (GO:0014032)2.50413621
139regulation of endothelial cell apoptotic process (GO:2000351)2.50018607
140chondroitin sulfate catabolic process (GO:0030207)2.49538656
141mesenchymal cell development (GO:0014031)2.44067348
142angiogenesis (GO:0001525)2.43053768
143positive regulation of endothelial cell proliferation (GO:0001938)2.42913035
144regulation of phospholipid biosynthetic process (GO:0071071)2.42765129
145regulation of vascular permeability (GO:0043114)2.41687792
146organ formation (GO:0048645)2.41289145
147negative regulation of mast cell activation (GO:0033004)2.38042371
148regulation of focal adhesion assembly (GO:0051893)2.37565685
149regulation of cell-substrate junction assembly (GO:0090109)2.37565685
150response to BMP (GO:0071772)2.37400051
151cellular response to BMP stimulus (GO:0071773)2.37400051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.72910395
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.40997524
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.35702103
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.56773916
5CLOCK_20551151_ChIP-Seq_293T_Human3.40629434
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.13794726
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.94641534
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.82580247
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.77280344
10CJUN_26792858_Chip-Seq_BT549_Human2.75316078
11GATA2_21666600_ChIP-Seq_HMVEC_Human2.70555331
12EZH2_22144423_ChIP-Seq_EOC_Human2.68719269
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.62632545
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61923206
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.53312788
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.48537108
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40934524
18* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.33247020
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.30386715
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.26931618
21GBX2_23144817_ChIP-Seq_PC3_Human2.22900899
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.22684856
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.11099353
24* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03071599
25* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.96655735
26BRD4_25478319_ChIP-Seq_HGPS_Human1.95871507
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95358758
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.94270950
29* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92593819
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.91717902
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.89202561
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.86330044
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81625899
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.80640025
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.80640025
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79543256
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76636221
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75579321
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72800237
40P300_19829295_ChIP-Seq_ESCs_Human1.72140438
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70543115
42SOX2_20726797_ChIP-Seq_SW620_Human1.69662833
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69019696
44SMAD4_21799915_ChIP-Seq_A2780_Human1.66086892
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.61196530
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60908489
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60852212
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58284647
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58009061
50* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55259948
51* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55259948
52* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55068382
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.55004367
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.55004367
55ZNF274_21170338_ChIP-Seq_K562_Hela1.53060883
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49874240
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48732923
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47913135
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47556573
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46187509
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46121522
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44168334
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.44133934
64TP53_18474530_ChIP-ChIP_U2OS_Human1.41611274
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40130094
66TAF15_26573619_Chip-Seq_HEK293_Human1.38520452
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.38134647
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34624947
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34527102
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.34451907
71AR_21572438_ChIP-Seq_LNCaP_Human1.34399436
72* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.33933454
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.33697091
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33468058
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.33377939
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.31714465
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30977894
78TP53_16413492_ChIP-PET_HCT116_Human1.30605304
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29830571
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29771330
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29098838
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.28907704
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28833580
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28756748
85* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27963652
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27689763
87GATA1_22025678_ChIP-Seq_K562_Human1.27679744
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27517336
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27502752
90SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27129293
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26678036
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26678036
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.24754512
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24715692
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22391328
96* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21708399
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21626365
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21202895
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20849379
100FUS_26573619_Chip-Seq_HEK293_Human1.20647662
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20373729
102EWS_26573619_Chip-Seq_HEK293_Human1.19931577
103AR_25329375_ChIP-Seq_VCAP_Human1.19602591
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.19444488
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19192711
106VDR_22108803_ChIP-Seq_LS180_Human1.18670338
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17001635
108* STAT3_23295773_ChIP-Seq_U87_Human1.15513634
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14907028
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.14479996
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13892352
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.13828636
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13434614
114IGF1R_20145208_ChIP-Seq_DFB_Human1.12727698
115STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12650921
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.10270325
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08890895
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.08875356
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08334905
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08294587
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07943567
122TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07831235
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06026518
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.05541600
125RUNX2_22187159_ChIP-Seq_PCA_Human1.05268371
126EGR1_19374776_ChIP-ChIP_THP-1_Human1.04820555
127* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04241486
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03812379
129* RING1B_27294783_Chip-Seq_ESCs_Mouse1.03179804
130YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03013703
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02897035
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02229283
133P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01971775
134* KDM2B_26808549_Chip-Seq_REH_Human1.01878693
135NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01325900
136* TCF4_23295773_ChIP-Seq_U87_Human1.00803129
137TCF4_22108803_ChIP-Seq_LS180_Human1.00736027
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00375195
139STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99240742
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98605788
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.97811399
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.97668951
143RACK7_27058665_Chip-Seq_MCF-7_Human0.97464045
144NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97024869
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96165153
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95819661
147BP1_19119308_ChIP-ChIP_Hs578T_Human0.95791107
148TCF4_18268006_ChIP-ChIP_LS174T_Human0.95682318
149* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94076429
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93509512
151SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90916724
152FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88840642
153ISL1_27105846_Chip-Seq_CPCs_Mouse0.88432981
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87950029
155BCAT_22108803_ChIP-Seq_LS180_Human0.87509802
156* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86780835
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86250635
158TP63_23658742_ChIP-Seq_EP156T_Human0.84719834
159SA1_22415368_ChIP-Seq_MEFs_Mouse0.84124613
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80481039
161VDR_24787735_ChIP-Seq_THP-1_Human0.79381595
162AHR_22903824_ChIP-Seq_MCF-7_Human0.77445930
163KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77274210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.35436269
2MP0005503_abnormal_tendon_morphology5.06824949
3MP0005275_abnormal_skin_tensile4.81128977
4MP0010368_abnormal_lymphatic_system4.37922259
5MP0004272_abnormal_basement_membrane4.12080032
6MP0006054_spinal_hemorrhage3.61682727
7MP0001879_abnormal_lymphatic_vessel3.52628273
8MP0003279_aneurysm3.52495593
9MP0003705_abnormal_hypodermis_morpholog3.39569947
10MP0001958_emphysema3.25569116
11MP0003724_increased_susceptibility_to1.99837722
12MP0000767_abnormal_smooth_muscle1.90054303
13MP0005623_abnormal_meninges_morphology1.87706176
14MP0003566_abnormal_cell_adhesion1.86911015
15MP0005508_abnormal_skeleton_morphology1.84809764
16MP0002108_abnormal_muscle_morphology1.80406169
17MP0009384_cardiac_valve_regurgitation1.78704767
18MP0002295_abnormal_pulmonary_circulatio1.76358418
19MP0002060_abnormal_skin_morphology1.75305094
20MP0000751_myopathy1.65867181
21MP0003828_pulmonary_edema1.58675270
22MP0005023_abnormal_wound_healing1.58427730
23MP0000013_abnormal_adipose_tissue1.56951250
24MP0005171_absent_coat_pigmentation1.55277442
25MP0005257_abnormal_intraocular_pressure1.46211520
26MP0000049_abnormal_middle_ear1.44421911
27MP0004885_abnormal_endolymph1.38436150
28MP0001542_abnormal_bone_strength1.35340186
29MP0003950_abnormal_plasma_membrane1.32679161
30MP0004084_abnormal_cardiac_muscle1.32360399
31MP0003091_abnormal_cell_migration1.31113850
32MP0005595_abnormal_vascular_smooth1.28569161
33MP0000750_abnormal_muscle_regeneration1.27908611
34MP0000733_abnormal_muscle_development1.26024617
35MP0009780_abnormal_chondrocyte_physiolo1.24950449
36MP0003385_abnormal_body_wall1.24866908
37MP0005167_abnormal_blood-brain_barrier1.23420068
38MP0010030_abnormal_orbit_morphology1.23075758
39MP0002138_abnormal_hepatobiliary_system1.21397695
40MP0006138_congestive_heart_failure1.16658804
41MP0002128_abnormal_blood_circulation1.16614520
42MP0003045_fibrosis1.16335090
43MP0000343_altered_response_to1.15015785
44MP0000778_abnormal_nervous_system1.14468452
45MP0001243_abnormal_dermal_layer1.14128817
46MP0005390_skeleton_phenotype1.14086227
47MP0005164_abnormal_response_to1.14078300
48MP0003755_abnormal_palate_morphology1.12254405
49MP0009250_abnormal_appendicular_skeleto1.08160070
50MP0003300_gastrointestinal_ulcer1.07909558
51MP0003935_abnormal_craniofacial_develop1.07777517
52MP0005165_increased_susceptibility_to1.07017911
53MP0002933_joint_inflammation1.06594882
54MP0004883_abnormal_blood_vessel1.06281255
55MP0003880_abnormal_central_pattern1.05951638
56MP0001614_abnormal_blood_vessel1.05643806
57MP0004085_abnormal_heartbeat1.04423502
58MP0004145_abnormal_muscle_electrophysio1.04412944
59MP0000749_muscle_degeneration1.02986154
60MP0000249_abnormal_blood_vessel0.99405369
61MP0002896_abnormal_bone_mineralization0.98454809
62MP0002653_abnormal_ependyma_morphology0.98007155
63MP0002925_abnormal_cardiovascular_devel0.96362706
64MP0002822_catalepsy0.95154027
65MP0000613_abnormal_salivary_gland0.95051630
66MP0005330_cardiomyopathy0.92305953
67MP0005385_cardiovascular_system_phenoty0.91890582
68MP0001544_abnormal_cardiovascular_syste0.91890582
69MP0001533_abnormal_skeleton_physiology0.91670559
70MP0008775_abnormal_heart_ventricle0.91447505
71MP0005409_darkened_coat_color0.91335879
72MP0002282_abnormal_trachea_morphology0.89807610
73MP0000163_abnormal_cartilage_morphology0.88905089
74MP0000569_abnormal_digit_pigmentation0.88386602
75MP0003868_abnormal_feces_composition0.88202558
76MP0002877_abnormal_melanocyte_morpholog0.87266585
77MP0004484_altered_response_of0.87236004
78MP0000003_abnormal_adipose_tissue0.86549030
79MP0002133_abnormal_respiratory_system0.85216546
80MP0005388_respiratory_system_phenotype0.85216546
81MP0002972_abnormal_cardiac_muscle0.84252562
82MP0005620_abnormal_muscle_contractility0.84032644
83MP0010630_abnormal_cardiac_muscle0.83460235
84MP0010352_gastrointestinal_tract_polyps0.83126665
85MP0009278_abnormal_bone_marrow0.82625532
86MP0005174_abnormal_tail_pigmentation0.81589262
87MP0003136_yellow_coat_color0.81511926
88MP0002932_abnormal_joint_morphology0.81422465
89MP0003115_abnormal_respiratory_system0.81401426
90MP0005084_abnormal_gallbladder_morpholo0.81347231
91MP0002998_abnormal_bone_remodeling0.81220695
92MP0003633_abnormal_nervous_system0.80374834
93MP0009379_abnormal_foot_pigmentation0.80097179
94MP0001915_intracranial_hemorrhage0.79952496
95MP0004233_abnormal_muscle_weight0.79224270
96MP0001175_abnormal_lung_morphology0.79177370
97MP0004087_abnormal_muscle_fiber0.78463273
98MP0005369_muscle_phenotype0.78067528
99MP0001784_abnormal_fluid_regulation0.76870754
100MP0003448_altered_tumor_morphology0.76188778
101MP0002115_abnormal_skeleton_extremities0.76186901
102MP0005367_renal/urinary_system_phenotyp0.75673743
103MP0000516_abnormal_urinary_system0.75673743
104MP0004215_abnormal_myocardial_fiber0.73409816
105MP0005187_abnormal_penis_morphology0.73243931
106MP0002113_abnormal_skeleton_development0.73059054
107MP0003941_abnormal_skin_development0.72901407
108MP0004036_abnormal_muscle_relaxation0.71540092
109MP0009697_abnormal_copulation0.70121456
110MP0000266_abnormal_heart_morphology0.69950864
111MP0002102_abnormal_ear_morphology0.69486236
112MP0002127_abnormal_cardiovascular_syste0.68807609
113MP0002168_other_aberrant_phenotype0.67618044
114MP0000759_abnormal_skeletal_muscle0.67474357
115MP0000534_abnormal_ureter_morphology0.67179443
116MP0004808_abnormal_hematopoietic_stem0.66877429
117MP0003283_abnormal_digestive_organ0.66269790
118MP0004859_abnormal_synaptic_plasticity0.66186124
119MP0000026_abnormal_inner_ear0.65489494
120MP0003567_abnormal_fetal_cardiomyocyte0.65314818
121MP0005197_abnormal_uvea_morphology0.65163157
122MP0002233_abnormal_nose_morphology0.64972871
123MP0004134_abnormal_chest_morphology0.64923869
124MP0001851_eye_inflammation0.64722388
125MP0009053_abnormal_anal_canal0.64475669
126MP0003011_delayed_dark_adaptation0.62729078
127MP0004782_abnormal_surfactant_physiolog0.62720840
128MP0000762_abnormal_tongue_morphology0.62138868
129MP0000462_abnormal_digestive_system0.61945803
130MP0002116_abnormal_craniofacial_bone0.61786693
131MP0003943_abnormal_hepatobiliary_system0.61121076
132MP0000465_gastrointestinal_hemorrhage0.60964804
133MP0002736_abnormal_nociception_after0.60576847
134MP0008004_abnormal_stomach_pH0.60259883
135MP0002166_altered_tumor_susceptibility0.60251894

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.84226481
2Premature rupture of membranes (HP:0001788)7.46705944
3Broad metatarsal (HP:0001783)5.65845919
4Aortic dissection (HP:0002647)5.39579590
5Aortic aneurysm (HP:0004942)5.13652120
6Ankle contracture (HP:0006466)4.64712987
7Cerebral aneurysm (HP:0004944)4.37929917
8Soft skin (HP:0000977)4.24235824
9Cervical subluxation (HP:0003308)4.06452855
10Shallow orbits (HP:0000586)4.00824913
11Wrist flexion contracture (HP:0001239)3.90856771
12Increased connective tissue (HP:0009025)3.80321340
13Atrophic scars (HP:0001075)3.78349836
14Bladder diverticulum (HP:0000015)3.74768615
15Spinal rigidity (HP:0003306)3.73697980
16Vascular tortuosity (HP:0004948)3.61141627
17Dilatation of the ascending aorta (HP:0005111)3.60079355
18Type 1 muscle fiber predominance (HP:0003803)3.43803124
19Hemiparesis (HP:0001269)3.39091806
20Fragile skin (HP:0001030)3.35312770
21Conjunctival telangiectasia (HP:0000524)3.28102347
22Peritonitis (HP:0002586)3.24382097
23Vertebral compression fractures (HP:0002953)3.23930407
24Adactyly (HP:0009776)3.14403056
25Wormian bones (HP:0002645)3.13547155
26Follicular hyperkeratosis (HP:0007502)3.13345363
27Arterial tortuosity (HP:0005116)3.12513587
28Round ear (HP:0100830)3.06425287
29Increased corneal curvature (HP:0100692)3.02749934
30Keratoconus (HP:0000563)3.02749934
31Blue sclerae (HP:0000592)3.00064015
32Mitral valve prolapse (HP:0001634)2.98579201
33Overgrowth (HP:0001548)2.96710969
34Limited hip movement (HP:0008800)2.95778771
35Abnormality of dentin (HP:0010299)2.94204331
36Hematochezia (HP:0002573)2.91302993
37Cerebral hemorrhage (HP:0001342)2.88712813
38Hemiplegia (HP:0002301)2.86158838
39Aneurysm (HP:0002617)2.83688901
40Nonimmune hydrops fetalis (HP:0001790)2.82090143
41Occipital encephalocele (HP:0002085)2.79888728
42Biconcave vertebral bodies (HP:0004586)2.70420155
43Pulmonary artery stenosis (HP:0004415)2.69075077
44Increased variability in muscle fiber diameter (HP:0003557)2.59195817
45Short hallux (HP:0010109)2.55723259
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.55358264
47Osteolytic defects of the hand bones (HP:0009699)2.55358264
48Abnormal delivery (HP:0001787)2.53270192
49Portal hypertension (HP:0001409)2.51835482
50Mildly elevated creatine phosphokinase (HP:0008180)2.49858337
51Esophageal varix (HP:0002040)2.49649655
52Venous abnormality (HP:0002624)2.49037029
53Neonatal short-limb short stature (HP:0008921)2.48679918
54Abnormality of the vasculature of the conjunctiva (HP:0008054)2.46374121
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44237271
56Short 4th metacarpal (HP:0010044)2.44237271
57Hyperextensible skin (HP:0000974)2.44062172
58Spontaneous hematomas (HP:0007420)2.43281736
59Venous insufficiency (HP:0005293)2.42766050
60Exotropia (HP:0000577)2.42608630
61Muscle fiber splitting (HP:0003555)2.40358247
62Spondylolisthesis (HP:0003302)2.36904888
63Genu recurvatum (HP:0002816)2.36619682
64Abnormality of skeletal muscle fiber size (HP:0012084)2.35559266
65Aplasia/Hypoplasia of the hallux (HP:0008362)2.33840086
66Joint laxity (HP:0001388)2.29696114
67Thin bony cortex (HP:0002753)2.28271522
68Abnormality of the acetabulum (HP:0003170)2.27168221
69Hyperventilation (HP:0002883)2.24158175
70Skull defect (HP:0001362)2.22784038
71Polycythemia (HP:0001901)2.21318751
72Hypoplasia of the iris (HP:0007676)2.20652094
73Mitral stenosis (HP:0001718)2.19904766
74Mitral regurgitation (HP:0001653)2.19248533
75Abnormality of the hepatic vasculature (HP:0006707)2.17996084
76Right ventricular cardiomyopathy (HP:0011663)2.17301326
77Slender build (HP:0001533)2.16174608
78Camptodactyly of toe (HP:0001836)2.15395827
79Striae distensae (HP:0001065)2.13448567
80Abnormality of the 4th metacarpal (HP:0010012)2.13334024
81Bowel diverticulosis (HP:0005222)2.10974894
82Short nail (HP:0001799)2.10576363
83Joint stiffness (HP:0001387)2.10420913
84Asymmetry of the thorax (HP:0001555)2.09907536
85Congenital, generalized hypertrichosis (HP:0004540)2.09637090
86Aortic valve stenosis (HP:0001650)2.08718128
87Myotonia (HP:0002486)2.07429323
88Abnormality of the ischium (HP:0003174)2.06974348
89Anterior segment dysgenesis (HP:0007700)2.04887103
90Difficulty climbing stairs (HP:0003551)2.02902842
91Bulbous nose (HP:0000414)2.01807784
92Elbow flexion contracture (HP:0002987)2.00299778
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.98715977
94Short tibia (HP:0005736)1.96645198
95Lipoatrophy (HP:0100578)1.96217463
96Ectopia lentis (HP:0001083)1.95306442
97True hermaphroditism (HP:0010459)1.94307318
98Neoplasm of the oral cavity (HP:0100649)1.93936543
99Scapular winging (HP:0003691)1.92457238
100Subacute progressive viral hepatitis (HP:0006572)1.92097274
101Wide anterior fontanel (HP:0000260)1.91048216
102Disproportionate tall stature (HP:0001519)1.89701068
103Atrial fibrillation (HP:0005110)1.89025196
104Abnormality of midbrain morphology (HP:0002418)1.88426706
105Molar tooth sign on MRI (HP:0002419)1.88426706
106Generalized amyotrophy (HP:0003700)1.85579994
107Lymphangioma (HP:0100764)1.84633629
108Aortic regurgitation (HP:0001659)1.83030487
109Broad ribs (HP:0000885)1.81177020
110Osteopenia (HP:0000938)1.81051472
111Hip contracture (HP:0003273)1.80138045
112Visceral angiomatosis (HP:0100761)1.79811213
113Infantile muscular hypotonia (HP:0008947)1.79369508
114Abnormality of the anterior chamber (HP:0000593)1.78065339
115Tarsal synostosis (HP:0008368)1.77970003
116Inguinal hernia (HP:0000023)1.77929664
117Pulmonary hypertension (HP:0002092)1.77508891
118Spinal cord lesions (HP:0100561)1.77289691
119Syringomyelia (HP:0003396)1.77289691
120Hemangiomatosis (HP:0007461)1.77157836
121Delayed closure of the anterior fontanelle (HP:0001476)1.76711849
122Enlarged penis (HP:0000040)1.75463918
123Pancreatic fibrosis (HP:0100732)1.74870845
124Difficulty running (HP:0009046)1.73756606
125Hypoplastic ischia (HP:0003175)1.73443173
126Mesomelia (HP:0003027)1.72943285
127Ulnar claw (HP:0001178)1.72799020
128Abnormality of the peritoneum (HP:0002585)1.71636261
129Atonic seizures (HP:0010819)1.71199331
130Supraventricular arrhythmia (HP:0005115)1.70892955
131Corneal dystrophy (HP:0001131)1.70200740
132Flexion contracture of toe (HP:0005830)1.69598689
133Joint contractures involving the joints of the feet (HP:0100492)1.69598689
134Abnormality of the nasal mucosa (HP:0000433)1.69247047
135Distal lower limb amyotrophy (HP:0008944)1.67545573
136Delayed cranial suture closure (HP:0000270)1.67419663
137Mesangial abnormality (HP:0001966)1.67406800
138Abnormality of the calf musculature (HP:0001430)1.67374457
139High pitched voice (HP:0001620)1.67011076
140Absent hand (HP:0004050)1.66652986
141Thin skin (HP:0000963)1.66415272
142Intestinal polyposis (HP:0200008)1.65380923
143Distal lower limb muscle weakness (HP:0009053)1.65378906
144Gingival overgrowth (HP:0000212)1.65045062
145Platyspondyly (HP:0000926)1.63944825
146Primary atrial arrhythmia (HP:0001692)1.63093696
147Pulmonic stenosis (HP:0001642)1.61908537
148Abnormal vertebral ossification (HP:0100569)1.60778395
149Fibular hypoplasia (HP:0003038)1.60001892
150Intestinal polyp (HP:0005266)1.58789262
151Bradycardia (HP:0001662)1.58569296
152Hyporeflexia of lower limbs (HP:0002600)1.58193146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.84487474
2KDR4.71911155
3TGFBR23.82595371
4ERN12.97139362
5TTN2.89893157
6MYLK2.78956362
7PDGFRA2.70681726
8DDR22.65986300
9TRIB32.63389651
10TGFBR12.57002417
11EPHB22.42396781
12FER2.06078841
13EPHA31.99386191
14DMPK1.92509802
15LATS11.80534632
16PTK2B1.77618215
17RIPK11.74270110
18EPHB11.69622759
19LATS21.65663253
20PKN21.62749597
21PAK21.61899635
22FRK1.61244646
23MAP3K31.48516907
24FGFR41.48491683
25NTRK11.44416577
26PTK61.42711764
27FES1.38685702
28NEK91.35719325
29MARK11.30794720
30MAP2K31.24266020
31BMX1.23955901
32SIK11.13804382
33TRPM71.13649008
34LRRK21.13203784
35PTK21.10491081
36PRKD21.09814728
37PAK41.09227334
38PNCK1.09062488
39PIK3CA1.08137468
40ERBB31.03840269
41MET1.03771417
42CCNB11.01403150
43CAMK1D1.01250316
44PDGFRB1.00574366
45CASK1.00312916
46PIK3CG0.99310301
47PINK10.99152047
48ILK0.95272082
49ZAK0.93829996
50MAPK130.91616544
51ERBB40.89492616
52MAP4K20.89303421
53NUAK10.87981961
54KIT0.87294734
55PDK20.86674765
56PIM20.86650392
57ROCK10.85203928
58NLK0.83857741
59FGFR30.82730573
60STK390.82493102
61STK30.81728508
62TNIK0.80984123
63CDK80.78877005
64PRKD10.74126194
65PRKG20.73665739
66WNK30.72783013
67NME20.72507644
68MUSK0.71116910
69MST1R0.71088986
70MOS0.70409361
71PAK30.69456875
72CSK0.68802564
73GRK10.68496446
74PRKCH0.67576931
75INSRR0.67391272
76GSK3A0.67280381
77MAP2K10.66809919
78ACVR1B0.66534494
79FGFR20.65709271
80CSNK1G10.65605864
81TESK10.65524547
82STK38L0.64834812
83RET0.62894635
84CSNK1G20.62098042
85JAK10.61482447
86RPS6KA40.61223818
87PHKG20.58806525
88PHKG10.58806525
89MAP3K40.58671970
90FGFR10.58379102
91MAP3K60.57971892
92MKNK20.57377867
93NTRK20.54940560
94GRK50.54243801
95CAMK1G0.53646016
96PAK60.52613323
97MAP2K20.52160293
98CSNK1G30.51965130
99MAPKAPK50.51427978
100MAPK120.51219975
101NTRK30.51065913
102MAPK150.50977018
103PRKD30.48741407
104CDK30.48739480
105INSR0.47252065
106TEC0.46766823
107IGF1R0.45745702
108CSNK1A1L0.45056652
109IRAK10.43867339
110LIMK10.43550878
111JAK30.42855192
112MAPKAPK30.41161845
113ADRBK20.41107302
114OBSCN0.40252120
115DAPK30.39696344
116PKN10.39040906
117BMPR1B0.38076072
118MAPK70.37414708
119SRC0.37139237
120PRKG10.36609715
121MTOR0.36399055
122CDK60.35657549
123ROCK20.35461037
124PRKCE0.34941532
125MAP2K70.34900782
126ERBB20.34177523
127WEE10.32789301
128CAMK2A0.32215290
129PRKAA20.29715181
130BCR0.29552053
131ABL10.29344169
132LMTK20.28803098
133CDK90.28063559
134PLK20.26973043
135EPHA40.26233118
136EGFR0.25931123
137FLT30.25300988
138CAMK2D0.25061662
139MAPKAPK20.24913332
140PRKCG0.23123944
141CDC42BPA0.22393771
142TBK10.21841979
143ABL20.21303299
144ADRBK10.21202457
145MAP3K70.19968594

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.15420284
2Focal adhesion_Homo sapiens_hsa045103.24379840
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.50873704
4AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.50675573
5Malaria_Homo sapiens_hsa051442.49689773
6Dilated cardiomyopathy_Homo sapiens_hsa054142.43747679
7Adherens junction_Homo sapiens_hsa045202.38416171
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.35914725
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.29806355
10Proteoglycans in cancer_Homo sapiens_hsa052052.22514315
11Protein digestion and absorption_Homo sapiens_hsa049742.19534108
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.11471690
13Amoebiasis_Homo sapiens_hsa051462.01119481
14TGF-beta signaling pathway_Homo sapiens_hsa043501.87812095
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.86281968
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.84116785
17Small cell lung cancer_Homo sapiens_hsa052221.83579780
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73440571
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.71965988
20Protein export_Homo sapiens_hsa030601.62607336
21Viral myocarditis_Homo sapiens_hsa054161.59218883
22Platelet activation_Homo sapiens_hsa046111.41204784
23Complement and coagulation cascades_Homo sapiens_hsa046101.39819750
24Glutamatergic synapse_Homo sapiens_hsa047241.38725840
25Hippo signaling pathway_Homo sapiens_hsa043901.37622576
26Bladder cancer_Homo sapiens_hsa052191.34432086
27Rap1 signaling pathway_Homo sapiens_hsa040151.33523769
28Toxoplasmosis_Homo sapiens_hsa051451.33281231
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.32113923
30MicroRNAs in cancer_Homo sapiens_hsa052061.31931997
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.28273541
32Pathways in cancer_Homo sapiens_hsa052001.21494316
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.20479364
34Tight junction_Homo sapiens_hsa045301.13656363
35Renin secretion_Homo sapiens_hsa049241.13405884
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.13035682
37Circadian entrainment_Homo sapiens_hsa047131.13028824
38Morphine addiction_Homo sapiens_hsa050321.12852567
39TNF signaling pathway_Homo sapiens_hsa046681.10432751
40Chronic myeloid leukemia_Homo sapiens_hsa052201.10045557
41Melanoma_Homo sapiens_hsa052181.08477520
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08404760
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07483624
44GABAergic synapse_Homo sapiens_hsa047271.06849419
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05887924
46cAMP signaling pathway_Homo sapiens_hsa040241.05740514
47HIF-1 signaling pathway_Homo sapiens_hsa040661.05457281
48Taste transduction_Homo sapiens_hsa047421.04443714
49Notch signaling pathway_Homo sapiens_hsa043301.03642442
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03285043
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03151819
52Basal cell carcinoma_Homo sapiens_hsa052171.02771323
53Caffeine metabolism_Homo sapiens_hsa002321.00804343
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00101950
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99883855
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99601403
57Pertussis_Homo sapiens_hsa051330.98321325
58Cocaine addiction_Homo sapiens_hsa050300.97472430
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97006295
60Serotonergic synapse_Homo sapiens_hsa047260.95534314
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94225086
62Prostate cancer_Homo sapiens_hsa052150.93782255
63Pancreatic cancer_Homo sapiens_hsa052120.92106859
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90882683
65Sulfur metabolism_Homo sapiens_hsa009200.90386257
66Shigellosis_Homo sapiens_hsa051310.90282191
67Leishmaniasis_Homo sapiens_hsa051400.89656873
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89652530
69Insulin secretion_Homo sapiens_hsa049110.89402173
70Salivary secretion_Homo sapiens_hsa049700.88679965
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88464327
72Dopaminergic synapse_Homo sapiens_hsa047280.88023429
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87356509
74Oxytocin signaling pathway_Homo sapiens_hsa049210.86886706
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86637719
76Nitrogen metabolism_Homo sapiens_hsa009100.86539363
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85422793
78Ras signaling pathway_Homo sapiens_hsa040140.85042851
79Insulin resistance_Homo sapiens_hsa049310.84978791
80Salmonella infection_Homo sapiens_hsa051320.82835503
81Gastric acid secretion_Homo sapiens_hsa049710.81313419
82HTLV-I infection_Homo sapiens_hsa051660.81060711
83Ovarian steroidogenesis_Homo sapiens_hsa049130.79487299
84Calcium signaling pathway_Homo sapiens_hsa040200.77721409
85Osteoclast differentiation_Homo sapiens_hsa043800.76051421
86Dorso-ventral axis formation_Homo sapiens_hsa043200.75638490
87Renal cell carcinoma_Homo sapiens_hsa052110.75420721
88Linoleic acid metabolism_Homo sapiens_hsa005910.73348150
89Hedgehog signaling pathway_Homo sapiens_hsa043400.71459005
90Phototransduction_Homo sapiens_hsa047440.71038213
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70464306
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70375907
93ABC transporters_Homo sapiens_hsa020100.69744745
94Wnt signaling pathway_Homo sapiens_hsa043100.68698397
95Long-term depression_Homo sapiens_hsa047300.68522664
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68515977
97Staphylococcus aureus infection_Homo sapiens_hsa051500.68440311
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68429443
99Axon guidance_Homo sapiens_hsa043600.66244265
100Melanogenesis_Homo sapiens_hsa049160.66173417
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64798285
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63165548
103Nicotine addiction_Homo sapiens_hsa050330.62873447
104Cardiac muscle contraction_Homo sapiens_hsa042600.62527493
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.62106523
106Propanoate metabolism_Homo sapiens_hsa006400.61015569
107Hepatitis B_Homo sapiens_hsa051610.60083493
108Galactose metabolism_Homo sapiens_hsa000520.59972124
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.58231810
110Amphetamine addiction_Homo sapiens_hsa050310.58153471
111Cholinergic synapse_Homo sapiens_hsa047250.57797523
112VEGF signaling pathway_Homo sapiens_hsa043700.56690648
113PPAR signaling pathway_Homo sapiens_hsa033200.56543720
114Apoptosis_Homo sapiens_hsa042100.56268711
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56043596
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.55972746
117Circadian rhythm_Homo sapiens_hsa047100.55428665
118Endocytosis_Homo sapiens_hsa041440.55425915
119Gap junction_Homo sapiens_hsa045400.55174794
120Pancreatic secretion_Homo sapiens_hsa049720.55103191
121African trypanosomiasis_Homo sapiens_hsa051430.54738042
122Other glycan degradation_Homo sapiens_hsa005110.54446560
123Colorectal cancer_Homo sapiens_hsa052100.53363686
124Glioma_Homo sapiens_hsa052140.52838656
125Selenocompound metabolism_Homo sapiens_hsa004500.52609562
126Prion diseases_Homo sapiens_hsa050200.51947389
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51124827
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.50631755
129Phagosome_Homo sapiens_hsa041450.49211590
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48776308
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48450734
132Estrogen signaling pathway_Homo sapiens_hsa049150.47768818
133Thyroid cancer_Homo sapiens_hsa052160.47734192
134Thyroid hormone synthesis_Homo sapiens_hsa049180.47694806
135FoxO signaling pathway_Homo sapiens_hsa040680.47552950
136Arachidonic acid metabolism_Homo sapiens_hsa005900.47266972
137Butanoate metabolism_Homo sapiens_hsa006500.47044233
138N-Glycan biosynthesis_Homo sapiens_hsa005100.43791038
139Hematopoietic cell lineage_Homo sapiens_hsa046400.42440770
140Lysosome_Homo sapiens_hsa041420.41867819
141Endometrial cancer_Homo sapiens_hsa052130.41639489
142MAPK signaling pathway_Homo sapiens_hsa040100.41266705
143Rheumatoid arthritis_Homo sapiens_hsa053230.41007704
144AMPK signaling pathway_Homo sapiens_hsa041520.40836243
145Prolactin signaling pathway_Homo sapiens_hsa049170.40288044
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40038773
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39911653

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