RHOBTB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.86688065
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.85019193
3synaptic vesicle maturation (GO:0016188)5.80437506
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.58471359
5vocalization behavior (GO:0071625)5.10973991
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.10259457
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.09307219
8synaptic vesicle exocytosis (GO:0016079)4.92889444
9regulation of synapse structural plasticity (GO:0051823)4.88054591
10regulation of synaptic vesicle exocytosis (GO:2000300)4.86483034
11regulation of glutamate receptor signaling pathway (GO:1900449)4.74112038
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.68178210
13glutamate secretion (GO:0014047)4.58234489
14neuronal action potential propagation (GO:0019227)4.53167691
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.40850779
16regulation of neuronal synaptic plasticity (GO:0048168)4.35611168
17exploration behavior (GO:0035640)4.34439359
18layer formation in cerebral cortex (GO:0021819)4.32439052
19dendritic spine morphogenesis (GO:0060997)4.27676949
20regulation of synaptic vesicle transport (GO:1902803)4.27495126
21protein localization to synapse (GO:0035418)4.24027156
22neurotransmitter secretion (GO:0007269)4.20130901
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.18220385
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.16390287
25activation of protein kinase A activity (GO:0034199)4.06257738
26prepulse inhibition (GO:0060134)4.04113699
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.97167478
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.94267642
29regulation of dendritic spine morphogenesis (GO:0061001)3.85469141
30long-term memory (GO:0007616)3.79658109
31G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.77901846
32neurotransmitter-gated ion channel clustering (GO:0072578)3.76987847
33synaptic transmission, glutamatergic (GO:0035249)3.75598044
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73471319
35neuromuscular process controlling balance (GO:0050885)3.71907470
36surfactant homeostasis (GO:0043129)3.70033193
37glutamate receptor signaling pathway (GO:0007215)3.68846624
38positive regulation of membrane potential (GO:0045838)3.64186666
39neuron-neuron synaptic transmission (GO:0007270)3.63395900
40L-amino acid import (GO:0043092)3.62981748
41auditory behavior (GO:0031223)3.61952674
42regulation of ARF protein signal transduction (GO:0032012)3.60866089
43neuron cell-cell adhesion (GO:0007158)3.58359056
44cellular potassium ion homeostasis (GO:0030007)3.57233451
45sodium ion export (GO:0071436)3.55243191
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54620616
47amino acid import (GO:0043090)3.53848603
48positive regulation of synapse maturation (GO:0090129)3.53038976
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52790924
50gamma-aminobutyric acid transport (GO:0015812)3.52534358
51regulation of postsynaptic membrane potential (GO:0060078)3.52261612
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51558326
53cell communication by electrical coupling (GO:0010644)3.47935716
54regulation of synaptic plasticity (GO:0048167)3.47146772
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.44067714
56proline transport (GO:0015824)3.40046570
57positive regulation of neurotransmitter transport (GO:0051590)3.39800100
58cerebellar granule cell differentiation (GO:0021707)3.37450500
59cerebellar Purkinje cell differentiation (GO:0021702)3.34519293
60transmission of nerve impulse (GO:0019226)3.32776098
61regulation of synapse maturation (GO:0090128)3.30647019
62membrane depolarization during action potential (GO:0086010)3.28617212
63positive regulation of neurotransmitter secretion (GO:0001956)3.28328179
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26977449
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.25820286
66neurotransmitter transport (GO:0006836)3.24330123
67neuron recognition (GO:0008038)3.20197535
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.19972602
69dopamine receptor signaling pathway (GO:0007212)3.18948318
70potassium ion import (GO:0010107)3.18501870
71long-term synaptic potentiation (GO:0060291)3.18025317
72behavioral defense response (GO:0002209)3.17062197
73behavioral fear response (GO:0001662)3.17062197
74response to auditory stimulus (GO:0010996)3.16762628
75striatum development (GO:0021756)3.16498315
76neuromuscular process controlling posture (GO:0050884)3.16347024
77regulation of neurotransmitter secretion (GO:0046928)3.15954548
78regulation of dendritic spine development (GO:0060998)3.14132910
79membrane depolarization (GO:0051899)3.11840733
80dendrite morphogenesis (GO:0048813)3.10031471
81cellular sodium ion homeostasis (GO:0006883)3.08537052
82regulation of neurotransmitter levels (GO:0001505)3.03116505
83regulation of neurotransmitter transport (GO:0051588)3.02231804
84membrane hyperpolarization (GO:0060081)3.02205700
85behavioral response to cocaine (GO:0048148)2.99607375
86cell migration in hindbrain (GO:0021535)2.99117842
87negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95624478
88neuromuscular process (GO:0050905)2.95554133
89regulation of voltage-gated calcium channel activity (GO:1901385)2.95304107
90dendritic spine organization (GO:0097061)2.94849133
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94808349
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94480985
93axonal fasciculation (GO:0007413)2.93232607
94neuronal ion channel clustering (GO:0045161)2.92648653
95synaptic vesicle endocytosis (GO:0048488)2.91539833
96glycine transport (GO:0015816)2.89618397
97positive regulation of dendritic spine development (GO:0060999)2.89326207
98fear response (GO:0042596)2.89012163
99social behavior (GO:0035176)2.87424470
100intraspecies interaction between organisms (GO:0051703)2.87424470
101chemical homeostasis within a tissue (GO:0048875)2.86697912
102positive regulation of synaptic transmission (GO:0050806)2.85101764
103regulation of vesicle fusion (GO:0031338)2.84838125
104synaptic transmission, dopaminergic (GO:0001963)2.83840843
105learning (GO:0007612)2.83100002
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81639025
107response to histamine (GO:0034776)2.80717132
108regulation of synaptic transmission (GO:0050804)2.80676166
109negative regulation of dendrite morphogenesis (GO:0050774)2.75832661
110cell communication involved in cardiac conduction (GO:0086065)2.71729133
111phosphate ion transmembrane transport (GO:0035435)2.68901082
112potassium ion homeostasis (GO:0055075)2.65977349
113adenosine receptor signaling pathway (GO:0001973)2.63599134
114positive regulation of Rap GTPase activity (GO:0032854)2.63459517
115cellular response to nitric oxide (GO:0071732)2.63215493
116protein localization to endosome (GO:0036010)2.61659996
117regulation of ARF GTPase activity (GO:0032312)2.58429156
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57741479
119cell-substrate adherens junction assembly (GO:0007045)2.57096344
120focal adhesion assembly (GO:0048041)2.57096344
121postsynaptic membrane organization (GO:0001941)2.56473946
122cellular response to monoamine stimulus (GO:0071868)2.54277689
123cellular response to catecholamine stimulus (GO:0071870)2.54277689
124cellular response to reactive nitrogen species (GO:1902170)2.50555568
125adherens junction assembly (GO:0034333)2.50473654
126positive regulation of dendrite development (GO:1900006)2.50356540
127protein targeting to plasma membrane (GO:0072661)2.49750964
128neuromuscular synaptic transmission (GO:0007274)2.47077514
129semaphorin-plexin signaling pathway (GO:0071526)2.45865290
130positive regulation of dendritic spine morphogenesis (GO:0061003)2.45273892
131regulation of dendrite morphogenesis (GO:0048814)2.45089272
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.44946505
133positive regulation of protein dephosphorylation (GO:0035307)2.44309772
134neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.42039422
135regulation of Rap GTPase activity (GO:0032317)2.38475138
136cell-cell junction maintenance (GO:0045217)2.34746123
137mating behavior (GO:0007617)2.33059829
138acidic amino acid transport (GO:0015800)2.31848942
139peptidyl-tyrosine autophosphorylation (GO:0038083)2.31433471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07873804
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.47735108
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03133118
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96674521
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95900723
6DROSHA_22980978_ChIP-Seq_HELA_Human2.91621121
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.85053015
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81222381
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81222381
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.77176795
11REST_21632747_ChIP-Seq_MESCs_Mouse2.75867555
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60727305
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50111137
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47557323
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.45889473
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.40927156
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38720906
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37949327
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36340875
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.34964792
21GBX2_23144817_ChIP-Seq_PC3_Human2.27065613
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22807945
23* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22632308
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.19337228
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18826768
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.08502570
27AR_21572438_ChIP-Seq_LNCaP_Human2.02931103
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92697624
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.91135576
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.89263804
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88141393
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86790702
33VDR_21846776_ChIP-Seq_THP-1_Human1.81927245
34* KDM2B_26808549_Chip-Seq_K562_Human1.81503246
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79260150
36RACK7_27058665_Chip-Seq_MCF-7_Human1.76577347
37* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.75761592
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.66464547
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64744002
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63082656
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61723515
42TCF7_22412390_ChIP-Seq_EML_Mouse1.59287280
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58361468
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57001521
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56666828
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.53703878
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51611191
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.50705621
49RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49754144
50P68_20966046_ChIP-Seq_HELA_Human1.49540404
51* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45046339
52* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43563727
53* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43052525
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40053810
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.39643966
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37537309
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37312755
58* KDM2B_26808549_Chip-Seq_DND41_Human1.37217091
59MYC_22102868_ChIP-Seq_BL_Human1.35820661
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33302800
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.33174619
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32508447
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31931265
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.30629956
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28490942
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26362410
67* AR_19668381_ChIP-Seq_PC3_Human1.26291593
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.24991207
69CTCF_27219007_Chip-Seq_Bcells_Human1.24881610
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23786814
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23457540
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.21436188
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20873104
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18861908
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18334438
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17610181
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17532143
78* KDM2B_26808549_Chip-Seq_JURKAT_Human1.17372754
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15784099
80SMAD4_21799915_ChIP-Seq_A2780_Human1.15046085
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14018525
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13463621
83* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12611039
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11655802
85* LXR_22292898_ChIP-Seq_THP-1_Human1.08780955
86TP53_23651856_ChIP-Seq_MEFs_Mouse1.08317693
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.08011382
88TBX20_22080862_ChIP-Seq_HEART_Mouse1.08011382
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07684762
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06928449
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05998288
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.05344747
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.05093693
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04646149
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03944661
96* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02266771
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02188501
98ZNF274_21170338_ChIP-Seq_K562_Hela1.00799250
99TP63_22573176_ChIP-Seq_HFKS_Human1.00526520
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99841334
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99124559
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.98884705
103* TP53_22127205_ChIP-Seq_IMR90_Human0.98695850
104SMC4_20622854_ChIP-Seq_HELA_Human0.98315587
105TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98129480
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97638401
107RUNX1_27514584_Chip-Seq_MCF-7_Human0.97570976
108JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96767674
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96274240
110* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95867578
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95437967
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95354629
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.94860543
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94782394
115* CLOCK_20551151_ChIP-Seq_293T_Human0.94686401
116OCT4_19829295_ChIP-Seq_ESCs_Human0.94345866
117AHR_22903824_ChIP-Seq_MCF-7_Human0.94099536
118* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93858141
119* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93474927
120WDR5_24793694_ChIP-Seq_LNCAP_Human0.91889546
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.91730036
122KLF4_19829295_ChIP-Seq_ESCs_Human0.90829510
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90512709
124CREB1_26743006_Chip-Seq_LNCaP_Human0.90029266
125* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89517852
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.88755879
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87699457
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86748167
129* STAT3_23295773_ChIP-Seq_U87_Human0.86660499
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.85775211
131* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85769624
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84429613
133DPY_21335234_ChIP-Seq_ESCs_Mouse0.84060608
134AR_25329375_ChIP-Seq_VCAP_Human0.83777977
135OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83168315
136TAF15_26573619_Chip-Seq_HEK293_Human0.81378801
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.81316054
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.80954103
139ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80422400
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78735996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.65252135
2MP0003880_abnormal_central_pattern4.39925226
3MP0002822_catalepsy4.23903302
4MP0003635_abnormal_synaptic_transmissio4.22805549
5MP0004270_analgesia3.57081068
6MP0002063_abnormal_learning/memory/cond3.45937753
7MP0009745_abnormal_behavioral_response3.38250060
8MP0005423_abnormal_somatic_nervous3.11018569
9MP0002064_seizures3.01980591
10MP0009046_muscle_twitch2.83699283
11MP0003705_abnormal_hypodermis_morpholog2.82466702
12MP0002572_abnormal_emotion/affect_behav2.76672296
13MP0001968_abnormal_touch/_nociception2.76018194
14MP0005409_darkened_coat_color2.54403713
15MP0001486_abnormal_startle_reflex2.51307134
16MP0002272_abnormal_nervous_system2.44929974
17MP0002734_abnormal_mechanical_nocicepti2.31656353
18MP0001958_emphysema2.22760150
19MP0009780_abnormal_chondrocyte_physiolo2.22651122
20MP0008569_lethality_at_weaning2.15683672
21MP0002909_abnormal_adrenal_gland2.12062147
22MP0002735_abnormal_chemical_nociception2.01761146
23MP0002733_abnormal_thermal_nociception1.93821441
24MP0002736_abnormal_nociception_after1.90553193
25MP0001970_abnormal_pain_threshold1.87757370
26MP0004885_abnormal_endolymph1.87541466
27MP0001501_abnormal_sleep_pattern1.85307481
28MP0004811_abnormal_neuron_physiology1.84437109
29MP0002067_abnormal_sensory_capabilities1.81645586
30MP0000751_myopathy1.79816382
31MP0002557_abnormal_social/conspecific_i1.78838614
32MP0001440_abnormal_grooming_behavior1.78635045
33MP0005386_behavior/neurological_phenoty1.77284508
34MP0004924_abnormal_behavior1.77284508
35MP0004858_abnormal_nervous_system1.75845390
36MP0002184_abnormal_innervation1.67401684
37MP0004782_abnormal_surfactant_physiolog1.66078045
38MP0000778_abnormal_nervous_system1.65513879
39MP0001986_abnormal_taste_sensitivity1.62361252
40MP0003329_amyloid_beta_deposits1.61474167
41MP0008961_abnormal_basal_metabolism1.59479233
42MP0003091_abnormal_cell_migration1.53224084
43MP0000955_abnormal_spinal_cord1.49644689
44MP0000604_amyloidosis1.48753422
45MP0001348_abnormal_lacrimal_gland1.44194631
46MP0003879_abnormal_hair_cell1.42625927
47MP0002066_abnormal_motor_capabilities/c1.42524733
48MP0003690_abnormal_glial_cell1.41878907
49MP0001529_abnormal_vocalization1.39583826
50MP0002882_abnormal_neuron_morphology1.37813585
51MP0005646_abnormal_pituitary_gland1.34680730
52MP0002837_dystrophic_cardiac_calcinosis1.34090106
53MP0003633_abnormal_nervous_system1.28607516
54MP0000920_abnormal_myelination1.27800672
55MP0006276_abnormal_autonomic_nervous1.24305182
56MP0003183_abnormal_peptide_metabolism1.23210200
57MP0000569_abnormal_digit_pigmentation1.22889202
58MP0003646_muscle_fatigue1.18255036
59MP0003137_abnormal_impulse_conducting1.17213368
60MP0004145_abnormal_muscle_electrophysio1.17212477
61MP0002152_abnormal_brain_morphology1.16385077
62MP0001984_abnormal_olfaction1.13772526
63MP0004085_abnormal_heartbeat1.13655269
64MP0001502_abnormal_circadian_rhythm1.12882405
65MP0005171_absent_coat_pigmentation1.12724310
66MP0003787_abnormal_imprinting1.12607529
67MP0009840_abnormal_foam_cell1.12443109
68MP0004142_abnormal_muscle_tone1.11856396
69MP0008874_decreased_physiological_sensi1.10276981
70MP0002133_abnormal_respiratory_system1.09500494
71MP0005388_respiratory_system_phenotype1.09500494
72MP0003172_abnormal_lysosome_physiology1.06902751
73MP0001849_ear_inflammation1.06734748
74MP0008872_abnormal_physiological_respon1.04529014
75MP0000003_abnormal_adipose_tissue1.03559932
76MP0005645_abnormal_hypothalamus_physiol1.03429015
77MP0003631_nervous_system_phenotype1.02466082
78MP0003283_abnormal_digestive_organ1.01971835
79MP0004215_abnormal_myocardial_fiber0.99157161
80MP0000579_abnormal_nail_morphology0.97493773
81MP0006138_congestive_heart_failure0.95155674
82MP0005058_abnormal_lysosome_morphology0.93540887
83MP0003566_abnormal_cell_adhesion0.92994380
84MP0001905_abnormal_dopamine_level0.92901785
85MP0003122_maternal_imprinting0.90987548
86MP0002069_abnormal_eating/drinking_beha0.90668019
87MP0004233_abnormal_muscle_weight0.90073831
88MP0005394_taste/olfaction_phenotype0.87441740
89MP0005499_abnormal_olfactory_system0.87441740
90MP0003123_paternal_imprinting0.84833463
91MP0000013_abnormal_adipose_tissue0.84669805
92MP0002229_neurodegeneration0.84455464
93MP0002249_abnormal_larynx_morphology0.84339124
94MP0000747_muscle_weakness0.82885277
95MP0004510_myositis0.82573263
96MP0005166_decreased_susceptibility_to0.81346811
97MP0002090_abnormal_vision0.79624668
98MP0008004_abnormal_stomach_pH0.78199504
99MP0003075_altered_response_to0.78172809
100MP0005535_abnormal_body_temperature0.77097810
101MP0003453_abnormal_keratinocyte_physiol0.76959761
102MP0004130_abnormal_muscle_cell0.74909224
103MP0005257_abnormal_intraocular_pressure0.74762718
104MP0001188_hyperpigmentation0.74755525
105MP0008260_abnormal_autophagy0.74579082
106MP0000749_muscle_degeneration0.73912082
107MP0010234_abnormal_vibrissa_follicle0.73694150
108MP0005076_abnormal_cell_differentiation0.73641230
109MP0003045_fibrosis0.71649733
110MP0004036_abnormal_muscle_relaxation0.71551918
111MP0000750_abnormal_muscle_regeneration0.71511737
112MP0003634_abnormal_glial_cell0.71434611
113MP0004742_abnormal_vestibular_system0.70986712
114MP0002234_abnormal_pharynx_morphology0.70466445
115MP0004087_abnormal_muscle_fiber0.69749806
116MP0000681_abnormal_thyroid_gland0.68199057
117MP0002089_abnormal_postnatal_growth/wei0.67659682
118MP0003861_abnormal_nervous_system0.66315701
119MP0002752_abnormal_somatic_nervous0.66048169
120MP0001177_atelectasis0.65819617
121MP0001485_abnormal_pinna_reflex0.65783826
122MP0005620_abnormal_muscle_contractility0.65020665
123MP0001664_abnormal_digestion0.64497342
124MP0005551_abnormal_eye_electrophysiolog0.64361987
125MP0000537_abnormal_urethra_morphology0.64215342
126MP0004484_altered_response_of0.63829093
127MP0003303_peritoneal_inflammation0.63209538
128MP0004084_abnormal_cardiac_muscle0.63098386
129MP0000631_abnormal_neuroendocrine_gland0.63058577
130MP0000759_abnormal_skeletal_muscle0.61574106
131MP0010769_abnormal_survival0.60663004
132MP0010386_abnormal_urinary_bladder0.59998000
133MP0005375_adipose_tissue_phenotype0.59786829
134MP0001943_abnormal_respiration0.59368651
135MP0003632_abnormal_nervous_system0.57019504
136MP0010768_mortality/aging0.56793435
137MP0005187_abnormal_penis_morphology0.56458192
138MP0005330_cardiomyopathy0.56040722
139MP0005623_abnormal_meninges_morphology0.55580703
140MP0010770_preweaning_lethality0.55528368

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.09582636
2Focal motor seizures (HP:0011153)6.50181228
3Focal seizures (HP:0007359)5.13612908
4Visual hallucinations (HP:0002367)4.79532623
5Progressive cerebellar ataxia (HP:0002073)4.39456744
6Neurofibrillary tangles (HP:0002185)3.80607606
7Epileptic encephalopathy (HP:0200134)3.78174976
8Febrile seizures (HP:0002373)3.74816540
9Action tremor (HP:0002345)3.69183237
10Atonic seizures (HP:0010819)3.68808748
11Interstitial pulmonary disease (HP:0006530)3.53116891
12Ankle clonus (HP:0011448)3.48206433
13Poor eye contact (HP:0000817)3.44458389
14Annular pancreas (HP:0001734)3.38229017
15Impaired vibration sensation in the lower limbs (HP:0002166)3.34354785
16Absence seizures (HP:0002121)3.34057166
17Cerebral inclusion bodies (HP:0100314)3.32681261
18Depression (HP:0000716)3.31516544
19Dysmetric saccades (HP:0000641)3.27913357
20Abnormal social behavior (HP:0012433)3.25106485
21Impaired social interactions (HP:0000735)3.25106485
22Broad-based gait (HP:0002136)3.24586040
23Abnormality of the lower motor neuron (HP:0002366)3.22870973
24Generalized tonic-clonic seizures (HP:0002069)3.18974201
25Urinary urgency (HP:0000012)3.18017004
26Urinary bladder sphincter dysfunction (HP:0002839)3.17118926
27Akinesia (HP:0002304)3.14213712
28Dysdiadochokinesis (HP:0002075)3.13206616
29Genetic anticipation (HP:0003743)3.03345332
30Truncal ataxia (HP:0002078)3.01442326
31Dialeptic seizures (HP:0011146)3.01371722
32Amblyopia (HP:0000646)2.94559789
33Termporal pattern (HP:0011008)2.90567415
34Insidious onset (HP:0003587)2.90567415
35Gaze-evoked nystagmus (HP:0000640)2.87368853
36Papilledema (HP:0001085)2.85929954
37Supranuclear gaze palsy (HP:0000605)2.85750309
38Ventricular fibrillation (HP:0001663)2.78102670
39Impaired smooth pursuit (HP:0007772)2.77007042
40Anxiety (HP:0000739)2.73529898
41Neuronal loss in central nervous system (HP:0002529)2.73291096
42Turricephaly (HP:0000262)2.72608451
43Pointed chin (HP:0000307)2.71228225
44Scanning speech (HP:0002168)2.70608863
45Bundle branch block (HP:0011710)2.69733174
46Stereotypic behavior (HP:0000733)2.68754412
47Dysmetria (HP:0001310)2.67150480
48Postural instability (HP:0002172)2.60433949
49Apathy (HP:0000741)2.57246326
50Thin bony cortex (HP:0002753)2.56409294
51Megalencephaly (HP:0001355)2.54715697
52Resting tremor (HP:0002322)2.54057450
53Pheochromocytoma (HP:0002666)2.52159649
54Torticollis (HP:0000473)2.52122538
55Upper limb amyotrophy (HP:0009129)2.49915629
56Distal upper limb amyotrophy (HP:0007149)2.49915629
57Spastic gait (HP:0002064)2.49460635
58Hemiplegia (HP:0002301)2.46454542
59Abnormal eating behavior (HP:0100738)2.45775611
60Sudden death (HP:0001699)2.43135581
61Cerebral aneurysm (HP:0004944)2.39537408
62Lower limb amyotrophy (HP:0007210)2.39215064
63Focal dystonia (HP:0004373)2.39150383
64Insomnia (HP:0100785)2.37947816
65Distal lower limb amyotrophy (HP:0008944)2.35141860
66Prolonged QT interval (HP:0001657)2.35090644
67Neuroendocrine neoplasm (HP:0100634)2.33513878
68Diminished motivation (HP:0000745)2.32488191
69Abnormality of ocular smooth pursuit (HP:0000617)2.31806825
70Hyperventilation (HP:0002883)2.25930239
71Hyporeflexia of lower limbs (HP:0002600)2.25517418
72Ulnar bowing (HP:0003031)2.25439078
73Bronchomalacia (HP:0002780)2.25228864
74Mutism (HP:0002300)2.24103720
75Impaired vibratory sensation (HP:0002495)2.23554661
76Generalized hypotonia (HP:0001290)2.22634132
77Abnormal EKG (HP:0003115)2.21680604
78Neoplasm of the peripheral nervous system (HP:0100007)2.21237672
79Centrally nucleated skeletal muscle fibers (HP:0003687)2.20176211
80Exercise-induced myalgia (HP:0003738)2.18589421
81Excessive salivation (HP:0003781)2.18236963
82Drooling (HP:0002307)2.18236963
83Hemiparesis (HP:0001269)2.13619312
84Hyperacusis (HP:0010780)2.12459398
85Fetal akinesia sequence (HP:0001989)2.07602918
86Hand muscle atrophy (HP:0009130)2.06621549
87Bradykinesia (HP:0002067)2.05950234
88Craniofacial dystonia (HP:0012179)2.05207288
89Foot dorsiflexor weakness (HP:0009027)2.04596552
90Distal lower limb muscle weakness (HP:0009053)2.03002208
91Status epilepticus (HP:0002133)2.02523572
92Growth hormone excess (HP:0000845)2.02027127
93Abnormal atrioventricular conduction (HP:0005150)2.00246300
94Amyotrophic lateral sclerosis (HP:0007354)1.98984204
95Diplopia (HP:0000651)1.96993477
96Abnormality of binocular vision (HP:0011514)1.96993477
97Lower limb muscle weakness (HP:0007340)1.96665192
98Epileptiform EEG discharges (HP:0011182)1.95489065
99Central scotoma (HP:0000603)1.94887397
100Increased variability in muscle fiber diameter (HP:0003557)1.93345775
101Intention tremor (HP:0002080)1.92156988
102Aqueductal stenosis (HP:0002410)1.91604906
103EEG with generalized epileptiform discharges (HP:0011198)1.91413966
104Nuclear cataract (HP:0100018)1.91111650
105Rapidly progressive (HP:0003678)1.89775382
106Lower limb asymmetry (HP:0100559)1.89581546
107Shallow orbits (HP:0000586)1.88956371
108Myopathic facies (HP:0002058)1.88772993
109Incomplete penetrance (HP:0003829)1.88759641
110Limb dystonia (HP:0002451)1.87823544
111Deep palmar crease (HP:0006191)1.87063156
112Heart block (HP:0012722)1.86861530
113Hypsarrhythmia (HP:0002521)1.86377386
114Difficulty running (HP:0009046)1.85487781
115Abnormality of the foot musculature (HP:0001436)1.85032351
116Shoulder girdle muscle weakness (HP:0003547)1.84922639
117Obstructive sleep apnea (HP:0002870)1.83398201
118Increased connective tissue (HP:0009025)1.83148784
119Ankyloglossia (HP:0010296)1.82869326
120Neonatal onset (HP:0003623)1.81936784
121Progressive inability to walk (HP:0002505)1.81787387
122Atrophic scars (HP:0001075)1.81280112
123Rigidity (HP:0002063)1.81056869
124Abnormality of the corticospinal tract (HP:0002492)1.79497612
125Hammertoe (HP:0001765)1.79087581
126Hypercortisolism (HP:0001578)1.78538285
127Clonus (HP:0002169)1.77480373
128Myotonia (HP:0002486)1.77431680
129Atrioventricular block (HP:0001678)1.76495972
130Spinal canal stenosis (HP:0003416)1.76408697
131Primary atrial arrhythmia (HP:0001692)1.76334503
132Distal sensory impairment (HP:0002936)1.75395513
133Hypoventilation (HP:0002791)1.69376680
134Mildly elevated creatine phosphokinase (HP:0008180)1.67154732
135Decreased motor nerve conduction velocity (HP:0003431)1.66588319
136Dementia (HP:0000726)1.66536510
137Abnormality of the fingertips (HP:0001211)1.66052213
138Onion bulb formation (HP:0003383)1.65653018
139Slow progression (HP:0003677)1.64884817
140Difficulty climbing stairs (HP:0003551)1.63632363
141Peripheral hypomyelination (HP:0007182)1.63312114
142Aplasia involving bones of the upper limbs (HP:0009823)1.63086190
143Aplasia of the phalanges of the hand (HP:0009802)1.63086190
144Aplasia involving bones of the extremities (HP:0009825)1.63086190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.04009715
2MAP3K94.15221570
3NTRK34.01436810
4MARK12.81674628
5DAPK22.50099008
6MAP3K42.45281089
7MINK12.36791168
8KSR22.32475105
9PRKD32.28281788
10PAK62.22008854
11CAMKK12.15875028
12NTRK22.00714505
13ERN11.89911709
14SIK21.80652737
15KSR11.71786448
16TAOK11.64701694
17NTRK11.59745308
18MAP2K71.56465080
19RIPK41.55654185
20CDK51.50748498
21MAP2K41.50315142
22STK381.46299539
23DAPK11.43525072
24ALK1.42715284
25TYRO31.41255082
26PHKG21.40877455
27PHKG11.40877455
28CDK121.31252259
29MAP3K121.29912706
30FES1.26489073
31TRIB31.25929614
32UHMK11.25786407
33PRKCH1.21983786
34RIPK11.19427256
35SIK11.16443422
36ARAF1.16422970
37STK111.14604323
38PRPF4B1.14375845
39LMTK21.13630458
40TTN1.11607069
41MAPK131.11379030
42PNCK1.11182678
43MAP3K131.08103862
44PINK11.05495714
45WNK11.02621746
46CDK191.00904587
47MARK20.99182879
48SGK2230.96290611
49SGK4940.96290611
50CAMK10.95639891
51CAMKK20.95445028
52SGK30.94116279
53PRKCG0.93630061
54GRK50.92903346
55MAPK150.92690681
56SGK20.89942336
57CDK150.88506484
58LATS20.88228087
59RAF10.87829073
60CDK180.87279296
61MAP3K100.86927202
62MAP3K20.86869130
63RET0.86850950
64PKN20.85379451
65CDC42BPA0.84609567
66CDK140.82981067
67PLK20.81438073
68NEK60.80619613
69TNIK0.79985873
70CDK11A0.78999071
71SGK10.77756192
72DMPK0.77246613
73TESK10.77021657
74CAMK1G0.76284631
75PDK10.75540961
76EPHB20.75517675
77MST1R0.74539831
78NEK10.73585339
79CAMK2A0.70740000
80CAMK40.69748020
81PRKD20.69229557
82MAPK70.68331013
83PDPK10.68306926
84CASK0.66228932
85MAP3K70.64169625
86SCYL20.63491301
87EPHB10.62923221
88MTOR0.58944023
89MOS0.57726535
90RPS6KA30.57721132
91PAK30.57579655
92GRK60.56349013
93PRKCZ0.56078705
94IRAK20.55974552
95CAMK2B0.54571498
96MAP3K10.53537097
97TNK20.52792656
98RPS6KA20.52368568
99CAMK2G0.52069173
100LATS10.52044240
101MAPK110.51962891
102DAPK30.51391140
103MAP2K10.50908773
104CSNK1G20.50302327
105MAPK100.50227556
106PTK2B0.50206878
107FGFR40.49915896
108BRAF0.49475326
109FYN0.48991664
110CAMK1D0.48862142
111BRSK10.46576900
112BLK0.46113556
113ICK0.45939971
114MET0.45558221
115MAPK40.44859715
116EEF2K0.44368491
117SMG10.44364178
118DYRK1A0.43483190
119DDR20.43132258
120PTK20.42896093
121OBSCN0.42642235
122JAK10.40188487
123DYRK1B0.39296166
124MAP4K10.39135854
125ROCK20.39123991
126MAPK120.39091045
127PRKD10.38217831
128HIPK20.37156306
129PRKCB0.36990334
130PDGFRA0.33741388
131MAP3K110.31527451

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.94391735
2Nicotine addiction_Homo sapiens_hsa050332.84780750
3Synaptic vesicle cycle_Homo sapiens_hsa047212.71942413
4Long-term potentiation_Homo sapiens_hsa047202.63324896
5Circadian entrainment_Homo sapiens_hsa047132.58186639
6Morphine addiction_Homo sapiens_hsa050322.40556066
7GABAergic synapse_Homo sapiens_hsa047272.40037720
8Glutamatergic synapse_Homo sapiens_hsa047242.39183054
9Amphetamine addiction_Homo sapiens_hsa050312.31743280
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27011695
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22471435
12Dopaminergic synapse_Homo sapiens_hsa047282.13864792
13Cholinergic synapse_Homo sapiens_hsa047251.97386185
14Salivary secretion_Homo sapiens_hsa049701.97335733
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91843362
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.90498341
17Insulin secretion_Homo sapiens_hsa049111.88552226
18Gastric acid secretion_Homo sapiens_hsa049711.84107306
19Oxytocin signaling pathway_Homo sapiens_hsa049211.76740119
20Cocaine addiction_Homo sapiens_hsa050301.74948292
21Renin secretion_Homo sapiens_hsa049241.63021866
22GnRH signaling pathway_Homo sapiens_hsa049121.55572503
23Calcium signaling pathway_Homo sapiens_hsa040201.52873782
24Gap junction_Homo sapiens_hsa045401.49512865
25Taste transduction_Homo sapiens_hsa047421.48729337
26Long-term depression_Homo sapiens_hsa047301.45917222
27Glioma_Homo sapiens_hsa052141.36684430
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33392238
29Serotonergic synapse_Homo sapiens_hsa047261.30369088
30Estrogen signaling pathway_Homo sapiens_hsa049151.30102210
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28888859
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28556555
33Nitrogen metabolism_Homo sapiens_hsa009101.24395674
34cAMP signaling pathway_Homo sapiens_hsa040241.24189430
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22125624
36Type II diabetes mellitus_Homo sapiens_hsa049301.18812294
37Dorso-ventral axis formation_Homo sapiens_hsa043201.18592775
38Dilated cardiomyopathy_Homo sapiens_hsa054141.14725514
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13379086
40Cardiac muscle contraction_Homo sapiens_hsa042601.12639843
41Melanogenesis_Homo sapiens_hsa049161.11323768
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.07892407
43ErbB signaling pathway_Homo sapiens_hsa040121.07085077
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99994334
45Axon guidance_Homo sapiens_hsa043600.98378636
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94277991
47Oocyte meiosis_Homo sapiens_hsa041140.94198513
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.92435384
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.91780761
50Non-small cell lung cancer_Homo sapiens_hsa052230.90165556
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89565552
52VEGF signaling pathway_Homo sapiens_hsa043700.87125373
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85175953
54Phototransduction_Homo sapiens_hsa047440.83154791
55Focal adhesion_Homo sapiens_hsa045100.81114569
56Choline metabolism in cancer_Homo sapiens_hsa052310.80745636
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.80050324
58Glucagon signaling pathway_Homo sapiens_hsa049220.79704413
59mTOR signaling pathway_Homo sapiens_hsa041500.79528958
60MAPK signaling pathway_Homo sapiens_hsa040100.79016499
61Endometrial cancer_Homo sapiens_hsa052130.78118784
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77425380
63Notch signaling pathway_Homo sapiens_hsa043300.74774957
64Vitamin B6 metabolism_Homo sapiens_hsa007500.74578588
65Insulin signaling pathway_Homo sapiens_hsa049100.72825775
66Renal cell carcinoma_Homo sapiens_hsa052110.72416333
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71716702
68Pancreatic secretion_Homo sapiens_hsa049720.71574883
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70293770
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70280698
71Thyroid hormone synthesis_Homo sapiens_hsa049180.69925429
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69356739
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69046398
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67617641
75Alcoholism_Homo sapiens_hsa050340.67342061
76Fructose and mannose metabolism_Homo sapiens_hsa000510.66327551
77Rap1 signaling pathway_Homo sapiens_hsa040150.65006031
78AMPK signaling pathway_Homo sapiens_hsa041520.64848848
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63903172
80Endocytosis_Homo sapiens_hsa041440.63833384
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63237612
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63205219
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61988578
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61116935
85ECM-receptor interaction_Homo sapiens_hsa045120.59938703
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58481500
87Arginine biosynthesis_Homo sapiens_hsa002200.58144590
88Ras signaling pathway_Homo sapiens_hsa040140.57419890
89Collecting duct acid secretion_Homo sapiens_hsa049660.56123146
90Protein digestion and absorption_Homo sapiens_hsa049740.54960149
91Ovarian steroidogenesis_Homo sapiens_hsa049130.54861572
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.54790313
93B cell receptor signaling pathway_Homo sapiens_hsa046620.54344085
94Circadian rhythm_Homo sapiens_hsa047100.54179482
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53024500
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52745655
97Chemokine signaling pathway_Homo sapiens_hsa040620.52449768
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51845003
99Inositol phosphate metabolism_Homo sapiens_hsa005620.51667080
100Colorectal cancer_Homo sapiens_hsa052100.50188278
101Tight junction_Homo sapiens_hsa045300.48585358
102Wnt signaling pathway_Homo sapiens_hsa043100.48565044
103Proteoglycans in cancer_Homo sapiens_hsa052050.47492359
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46409178
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.45812105
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.44997331
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42681527
108Adherens junction_Homo sapiens_hsa045200.42615596
109Hippo signaling pathway_Homo sapiens_hsa043900.41906720
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.41205420
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40661304
112Platelet activation_Homo sapiens_hsa046110.40218476
113Bile secretion_Homo sapiens_hsa049760.39659165
114Vibrio cholerae infection_Homo sapiens_hsa051100.38603339
115Prolactin signaling pathway_Homo sapiens_hsa049170.38482489
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37759256
117Prion diseases_Homo sapiens_hsa050200.36666327
118T cell receptor signaling pathway_Homo sapiens_hsa046600.35947734
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33072290
120Chronic myeloid leukemia_Homo sapiens_hsa052200.32646144

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