RHBDL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)5.76411833
2presynaptic membrane assembly (GO:0097105)5.19277193
3central nervous system myelination (GO:0022010)4.90910007
4axon ensheathment in central nervous system (GO:0032291)4.90910007
5synaptic vesicle maturation (GO:0016188)4.64118274
6pyrimidine nucleobase catabolic process (GO:0006208)4.58605243
7locomotory exploration behavior (GO:0035641)4.30658316
8dendritic spine morphogenesis (GO:0060997)4.21879760
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.17352918
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13169392
11cellular potassium ion homeostasis (GO:0030007)4.10469706
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96822428
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.91352099
14vocalization behavior (GO:0071625)3.89376378
15regulation of glutamate receptor signaling pathway (GO:1900449)3.83644345
16sodium ion export (GO:0071436)3.72788343
17layer formation in cerebral cortex (GO:0021819)3.66791676
18L-amino acid import (GO:0043092)3.61150886
19positive regulation of synaptic transmission, GABAergic (GO:0032230)3.60637296
20establishment of mitochondrion localization (GO:0051654)3.60088642
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59709737
22nucleobase catabolic process (GO:0046113)3.54486687
23cerebellar granule cell differentiation (GO:0021707)3.54461889
24regulation of synapse structural plasticity (GO:0051823)3.51632521
25synaptic vesicle exocytosis (GO:0016079)3.49534244
26regulation of neuronal synaptic plasticity (GO:0048168)3.46954079
27regulation of synaptic vesicle exocytosis (GO:2000300)3.43419942
28amino acid import (GO:0043090)3.41928780
29axonal fasciculation (GO:0007413)3.39681852
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.38803597
31negative regulation of cytosolic calcium ion concentration (GO:0051481)3.38576389
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.38255325
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.37511154
34cell migration in hindbrain (GO:0021535)3.36833056
35glial cell proliferation (GO:0014009)3.26494176
36neuron recognition (GO:0008038)3.23661688
37potassium ion import (GO:0010107)3.20630059
38neuromuscular process controlling balance (GO:0050885)3.20408066
39neuronal action potential propagation (GO:0019227)3.18160183
40protein localization to synapse (GO:0035418)3.16293926
41establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16146790
42mitochondrion transport along microtubule (GO:0047497)3.16146790
43regulation of synaptic vesicle transport (GO:1902803)3.15032620
44exploration behavior (GO:0035640)3.13268881
45neurotransmitter transport (GO:0006836)3.11105805
46substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.09866142
47substrate-independent telencephalic tangential migration (GO:0021826)3.09866142
48chemosensory behavior (GO:0007635)3.09535172
49synaptic transmission, glutamatergic (GO:0035249)3.09181400
50adult walking behavior (GO:0007628)3.09059047
51neuronal ion channel clustering (GO:0045161)3.07935527
52neuromuscular synaptic transmission (GO:0007274)3.07746078
53potassium ion homeostasis (GO:0055075)3.07018649
54striatum development (GO:0021756)3.06018312
55regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04275761
56spinal cord development (GO:0021510)3.03330747
57neuron cell-cell adhesion (GO:0007158)3.03045842
58auditory behavior (GO:0031223)3.01775605
59glutamate receptor signaling pathway (GO:0007215)3.00887031
60regulation of dendritic spine morphogenesis (GO:0061001)3.00565675
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99929736
62glutamate secretion (GO:0014047)2.98382937
63neurotransmitter secretion (GO:0007269)2.98252547
64dendritic spine organization (GO:0097061)2.98197067
65apical protein localization (GO:0045176)2.97420787
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96201882
67neuromuscular process controlling posture (GO:0050884)2.94822494
68transmission of nerve impulse (GO:0019226)2.94412923
69synaptic vesicle endocytosis (GO:0048488)2.93728716
70response to auditory stimulus (GO:0010996)2.93612491
71positive regulation of synapse assembly (GO:0051965)2.93297500
72forebrain neuron differentiation (GO:0021879)2.92592821
73cranial nerve development (GO:0021545)2.91666443
74regulation of neurotransmitter transport (GO:0051588)2.91245936
75prepulse inhibition (GO:0060134)2.89824868
76cell differentiation in hindbrain (GO:0021533)2.88972630
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88301864
78proline transport (GO:0015824)2.87527817
79neuron-neuron synaptic transmission (GO:0007270)2.86968189
80negative regulation of axonogenesis (GO:0050771)2.86935210
81synapse assembly (GO:0007416)2.86039035
82positive regulation of synapse maturation (GO:0090129)2.85916634
83positive regulation of dendritic spine morphogenesis (GO:0061003)2.85430141
84regulation of excitatory postsynaptic membrane potential (GO:0060079)2.83664175
85postsynaptic membrane organization (GO:0001941)2.82855407
86cell communication by electrical coupling (GO:0010644)2.82224164
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81772922
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80993587
89neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.79835546
90glycine transport (GO:0015816)2.78574188
91innervation (GO:0060384)2.77580451
92long-term memory (GO:0007616)2.77362886
93cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77277107
94cerebellum development (GO:0021549)2.76735672
95behavioral response to nicotine (GO:0035095)2.76131321
96neurotransmitter-gated ion channel clustering (GO:0072578)2.74312604
97paraxial mesoderm development (GO:0048339)2.74099305
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72828146
99G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.69907469
100positive regulation of membrane potential (GO:0045838)2.69750305
101spinal cord association neuron differentiation (GO:0021527)2.68986910
102regulation of postsynaptic membrane potential (GO:0060078)2.68723473
103neurotransmitter uptake (GO:0001504)2.68654679
104membrane depolarization during action potential (GO:0086010)2.67978019
105regulation of dendrite morphogenesis (GO:0048814)2.67294148
106positive regulation of neurotransmitter transport (GO:0051590)2.67158528
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65065247
108lateral sprouting from an epithelium (GO:0060601)2.64482311
109regulation of axon guidance (GO:1902667)2.64184600
110cell communication involved in cardiac conduction (GO:0086065)2.63760905
111gamma-aminobutyric acid transport (GO:0015812)2.60435477
112regulation of cAMP-dependent protein kinase activity (GO:2000479)2.60362424
113neuromuscular process (GO:0050905)2.59066419
114activation of protein kinase A activity (GO:0034199)2.58257813
115regulation of synaptic plasticity (GO:0048167)2.58107671
116regulation of synaptic transmission, glutamatergic (GO:0051966)2.57653705
117regulation of synaptic transmission, GABAergic (GO:0032228)2.55823641
118positive regulation of neurotransmitter secretion (GO:0001956)2.53813393
119regulation of respiratory system process (GO:0044065)2.52668377
120regulation of neurotransmitter secretion (GO:0046928)2.50639685
121membrane hyperpolarization (GO:0060081)2.50236014
122negative regulation of axon guidance (GO:1902668)2.49717899
123dendrite morphogenesis (GO:0048813)2.49643628
124central nervous system projection neuron axonogenesis (GO:0021952)2.49459218
125suckling behavior (GO:0001967)2.48165695
126regulation of voltage-gated calcium channel activity (GO:1901385)2.45942622
127auditory receptor cell stereocilium organization (GO:0060088)2.44699030
128multicellular organismal signaling (GO:0035637)2.44293207
129membrane depolarization (GO:0051899)2.43133059
130negative regulation of dendrite development (GO:2000171)2.43026596
131cerebellar Purkinje cell differentiation (GO:0021702)2.42639933
132dopamine receptor signaling pathway (GO:0007212)2.42086334
133learning (GO:0007612)2.42010746
134adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.41461638
135positive regulation of dendritic spine development (GO:0060999)2.41411398
136glomerular visceral epithelial cell development (GO:0072015)2.41232468
137regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40946889
138mechanosensory behavior (GO:0007638)2.40253373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95738898
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04457259
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94181646
4* EZH2_27304074_Chip-Seq_ESCs_Mouse2.92283679
5JARID2_20075857_ChIP-Seq_MESCs_Mouse2.89954117
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85916092
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84197228
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84197228
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.62252772
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61829900
11GBX2_23144817_ChIP-Seq_PC3_Human2.58223058
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55363354
13* RNF2_27304074_Chip-Seq_ESCs_Mouse2.54127952
14* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.45798020
15* EZH2_27294783_Chip-Seq_ESCs_Mouse2.43096825
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42697214
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42617167
18DROSHA_22980978_ChIP-Seq_HELA_Human2.40374102
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30798359
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28984874
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.24199354
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.23192165
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.12191690
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93847242
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89863658
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.86778112
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76380456
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.66388988
29RING1B_27294783_Chip-Seq_NPCs_Mouse1.65579214
30* RING1B_27294783_Chip-Seq_ESCs_Mouse1.64368754
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62639642
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60412594
33AR_21572438_ChIP-Seq_LNCaP_Human1.58862236
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56000425
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53881598
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48694725
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.48204969
38* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47555972
39WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46696690
40* KDM2B_26808549_Chip-Seq_K562_Human1.46345035
41* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44351277
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42476183
43* GATA1_26923725_Chip-Seq_HPCs_Mouse1.42410956
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41841982
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38339979
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34668542
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32952332
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30783390
49* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29680046
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25833072
51OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25639267
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22390406
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22390406
54* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22111821
55* RNF2_27304074_Chip-Seq_NSC_Mouse1.20130222
56* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20108748
57* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20010361
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14676431
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14579100
60SMAD4_21799915_ChIP-Seq_A2780_Human1.13909871
61CTCF_27219007_Chip-Seq_Bcells_Human1.13059653
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12399847
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11542589
64* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11234034
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09510030
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.09084867
67AR_19668381_ChIP-Seq_PC3_Human1.08322714
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07817688
69POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06979375
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05556306
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05030561
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05002999
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04273618
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03468427
75* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02875015
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02528322
77AHR_22903824_ChIP-Seq_MCF-7_Human1.02314916
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.02291436
79RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00556082
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00232185
81POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00038296
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00003094
83KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99823263
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99790602
85STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98314257
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98152959
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.97751683
88STAT3_23295773_ChIP-Seq_U87_Human0.97502235
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97256125
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96596572
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96186614
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95487474
93SMAD3_21741376_ChIP-Seq_HESCs_Human0.95421014
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94665985
95NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92996540
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.92460401
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.91696283
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91313254
99SOX9_26525672_Chip-Seq_HEART_Mouse0.88907310
100P300_19829295_ChIP-Seq_ESCs_Human0.88721498
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87242616
102* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87082128
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.86919694
104ISL1_27105846_Chip-Seq_CPCs_Mouse0.86563529
105AR_25329375_ChIP-Seq_VCAP_Human0.85838013
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85746504
107ZNF274_21170338_ChIP-Seq_K562_Hela0.84654512
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84596135
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84434019
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83931521
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.83632984
112TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83503820
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.83455833
114* TCF4_23295773_ChIP-Seq_U87_Human0.82135803
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81938627
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81688679
117SOX3_22085726_ChIP-Seq_NPCs_Mouse0.80466932
118POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.80079511
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79690778
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.79676445
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79439286
122DPY_21335234_ChIP-Seq_ESCs_Mouse0.79439205
123* KDM2B_26808549_Chip-Seq_JURKAT_Human0.79426606
124BCAT_22108803_ChIP-Seq_LS180_Human0.79227762
125NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.79201448
126STAT3_18555785_ChIP-Seq_MESCs_Mouse0.79197249
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79129884
128TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.78860866
129* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.76335980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.71220868
2MP0003880_abnormal_central_pattern3.32062141
3MP0003635_abnormal_synaptic_transmissio2.94551599
4MP0002822_catalepsy2.71544760
5MP0002063_abnormal_learning/memory/cond2.50675221
6MP0004270_analgesia2.41201756
7MP0009745_abnormal_behavioral_response2.36205740
8MP0002064_seizures2.24378395
9MP0003283_abnormal_digestive_organ2.23227683
10MP0005645_abnormal_hypothalamus_physiol2.11491116
11MP0008961_abnormal_basal_metabolism2.09645264
12MP0002572_abnormal_emotion/affect_behav2.09073152
13MP0006292_abnormal_olfactory_placode2.06872388
14MP0009046_muscle_twitch2.06241360
15MP0010030_abnormal_orbit_morphology2.04788742
16MP0005423_abnormal_somatic_nervous1.99901600
17MP0003136_yellow_coat_color1.98852796
18MP0002272_abnormal_nervous_system1.97260839
19MP0001486_abnormal_startle_reflex1.96330709
20MP0000778_abnormal_nervous_system1.89061217
21MP0005646_abnormal_pituitary_gland1.82308446
22MP0000566_synostosis1.79438164
23MP0002234_abnormal_pharynx_morphology1.76473466
24MP0006072_abnormal_retinal_apoptosis1.71302814
25MP0001502_abnormal_circadian_rhythm1.69101777
26MP0008569_lethality_at_weaning1.67934922
27MP0005499_abnormal_olfactory_system1.66441622
28MP0005394_taste/olfaction_phenotype1.66441622
29MP0002184_abnormal_innervation1.63362455
30MP0000751_myopathy1.61870956
31MP0000955_abnormal_spinal_cord1.58748960
32MP0001188_hyperpigmentation1.58127755
33MP0002638_abnormal_pupillary_reflex1.57165927
34MP0003329_amyloid_beta_deposits1.55779393
35MP0002653_abnormal_ependyma_morphology1.54115964
36MP0003137_abnormal_impulse_conducting1.52122983
37MP0002909_abnormal_adrenal_gland1.50932737
38MP0001968_abnormal_touch/_nociception1.48128524
39MP0004885_abnormal_endolymph1.47789826
40MP0002734_abnormal_mechanical_nocicepti1.46048516
41MP0002067_abnormal_sensory_capabilities1.43727087
42MP0001984_abnormal_olfaction1.43581848
43MP0002557_abnormal_social/conspecific_i1.43278814
44MP0001501_abnormal_sleep_pattern1.42850263
45MP0004811_abnormal_neuron_physiology1.41642361
46MP0008789_abnormal_olfactory_epithelium1.40794132
47MP0002751_abnormal_autonomic_nervous1.40054981
48MP0002882_abnormal_neuron_morphology1.39690111
49MP0003123_paternal_imprinting1.38619450
50MP0009780_abnormal_chondrocyte_physiolo1.37796333
51MP0004858_abnormal_nervous_system1.37445179
52MP0003787_abnormal_imprinting1.35736491
53MP0004133_heterotaxia1.32231369
54MP0001529_abnormal_vocalization1.30808586
55MP0001970_abnormal_pain_threshold1.29931925
56MP0000631_abnormal_neuroendocrine_gland1.28219725
57MP0004233_abnormal_muscle_weight1.26444916
58MP0001346_abnormal_lacrimal_gland1.23315700
59MP0002733_abnormal_thermal_nociception1.22800828
60MP0004924_abnormal_behavior1.22536144
61MP0005386_behavior/neurological_phenoty1.22536144
62MP0002735_abnormal_chemical_nociception1.17331677
63MP0002066_abnormal_motor_capabilities/c1.15215548
64MP0003690_abnormal_glial_cell1.14750282
65MP0009379_abnormal_foot_pigmentation1.13656826
66MP0003879_abnormal_hair_cell1.11432758
67MP0003121_genomic_imprinting1.09348367
68MP0002108_abnormal_muscle_morphology1.08560319
69MP0002752_abnormal_somatic_nervous1.07717999
70MP0005253_abnormal_eye_physiology1.07005016
71MP0005551_abnormal_eye_electrophysiolog1.06475129
72MP0004142_abnormal_muscle_tone1.06366042
73MP0002152_abnormal_brain_morphology1.05252473
74MP0002009_preneoplasia1.04806813
75MP0004085_abnormal_heartbeat1.03775331
76MP0000678_abnormal_parathyroid_gland1.03309042
77MP0003938_abnormal_ear_development0.99920282
78MP0001440_abnormal_grooming_behavior0.99308213
79MP0002837_dystrophic_cardiac_calcinosis0.98411382
80MP0006276_abnormal_autonomic_nervous0.97596319
81MP0003941_abnormal_skin_development0.96636390
82MP0000579_abnormal_nail_morphology0.96108792
83MP0000026_abnormal_inner_ear0.96026187
84MP0005623_abnormal_meninges_morphology0.95947614
85MP0001905_abnormal_dopamine_level0.94825962
86MP0001485_abnormal_pinna_reflex0.94707081
87MP0001177_atelectasis0.94239283
88MP0003122_maternal_imprinting0.92330255
89MP0002736_abnormal_nociception_after0.91262011
90MP0003632_abnormal_nervous_system0.90970197
91MP0004145_abnormal_muscle_electrophysio0.90695715
92MP0000049_abnormal_middle_ear0.89343599
93MP0000534_abnormal_ureter_morphology0.89276587
94MP0003890_abnormal_embryonic-extraembry0.88932208
95MP0003634_abnormal_glial_cell0.87201504
96MP0003633_abnormal_nervous_system0.86912087
97MP0003631_nervous_system_phenotype0.86089266
98MP0003861_abnormal_nervous_system0.86049418
99MP0002069_abnormal_eating/drinking_beha0.85795348
100MP0000013_abnormal_adipose_tissue0.85432309
101MP0001293_anophthalmia0.85412858
102MP0000537_abnormal_urethra_morphology0.85020624
103MP0002081_perinatal_lethality0.84156965
104MP0003119_abnormal_digestive_system0.83386748
105MP0001299_abnormal_eye_distance/0.77825001
106MP0000920_abnormal_myelination0.77818345
107MP0001963_abnormal_hearing_physiology0.75926494
108MP0004215_abnormal_myocardial_fiber0.75795105
109MP0002697_abnormal_eye_size0.75376486
110MP0002229_neurodegeneration0.75021336
111MP0002233_abnormal_nose_morphology0.74379258
112MP0000467_abnormal_esophagus_morphology0.73839825
113MP0004742_abnormal_vestibular_system0.73050907
114MP0001348_abnormal_lacrimal_gland0.72625533
115MP0002249_abnormal_larynx_morphology0.72226591
116MP0005409_darkened_coat_color0.71459953
117MP0003385_abnormal_body_wall0.70795297
118MP0000383_abnormal_hair_follicle0.69956454
119MP0005187_abnormal_penis_morphology0.69624516
120MP0005171_absent_coat_pigmentation0.69151761
121MP0003942_abnormal_urinary_system0.68793007
122MP0010678_abnormal_skin_adnexa0.67539522

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.10515952
2Focal motor seizures (HP:0011153)4.78940337
3Focal seizures (HP:0007359)3.32933931
4Febrile seizures (HP:0002373)3.20345571
5Epileptic encephalopathy (HP:0200134)3.12622371
6Annular pancreas (HP:0001734)3.01042140
7Visual hallucinations (HP:0002367)2.91242020
8Atonic seizures (HP:0010819)2.86804249
9Aplasia involving bones of the extremities (HP:0009825)2.81503829
10Aplasia involving bones of the upper limbs (HP:0009823)2.81503829
11Aplasia of the phalanges of the hand (HP:0009802)2.81503829
12Ventricular fibrillation (HP:0001663)2.79389230
13Ankyloglossia (HP:0010296)2.79335412
14Partial duplication of thumb phalanx (HP:0009944)2.75859080
15Progressive cerebellar ataxia (HP:0002073)2.66828206
16Coronal craniosynostosis (HP:0004440)2.65236986
17Hepatoblastoma (HP:0002884)2.65218222
18Broad-based gait (HP:0002136)2.62690365
19Alacrima (HP:0000522)2.59788742
20Impaired vibration sensation in the lower limbs (HP:0002166)2.54916567
21Split foot (HP:0001839)2.53414442
22Anomalous pulmonary venous return (HP:0010772)2.49384415
23Action tremor (HP:0002345)2.45257234
24Prolonged QT interval (HP:0001657)2.43631103
25Concave nail (HP:0001598)2.42591433
26Absence seizures (HP:0002121)2.40803089
27Abnormal eating behavior (HP:0100738)2.39445185
28Peripheral hypomyelination (HP:0007182)2.39354558
29Septo-optic dysplasia (HP:0100842)2.38598420
30Abnormality of the diencephalon (HP:0010662)2.38309155
31Abnormal EKG (HP:0003115)2.36870897
32Anophthalmia (HP:0000528)2.33624704
33Supranuclear gaze palsy (HP:0000605)2.32516801
34Intestinal atresia (HP:0011100)2.31736066
35Limb dystonia (HP:0002451)2.29329294
36Partial duplication of the phalanx of hand (HP:0009999)2.28454393
37Abnormality of the lower motor neuron (HP:0002366)2.27939739
38Megalencephaly (HP:0001355)2.27841640
39Hemiparesis (HP:0001269)2.27139451
40Aqueductal stenosis (HP:0002410)2.25012248
41Sleep apnea (HP:0010535)2.21352859
42Dysdiadochokinesis (HP:0002075)2.20424244
43Abnormality of binocular vision (HP:0011514)2.16993921
44Diplopia (HP:0000651)2.16993921
45Spastic gait (HP:0002064)2.15878260
46Anxiety (HP:0000739)2.15428403
47Depression (HP:0000716)2.15146877
48Abnormality of the pulmonary veins (HP:0011718)2.13899354
49Ankle clonus (HP:0011448)2.13279679
50Hypercortisolism (HP:0001578)2.12001733
51Polyphagia (HP:0002591)2.11141597
52Hemiplegia (HP:0002301)2.11057733
53Fetal akinesia sequence (HP:0001989)2.10595778
54Decreased lacrimation (HP:0000633)2.10494944
55Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10189711
56Dialeptic seizures (HP:0011146)2.10099957
57Drooling (HP:0002307)2.09186489
58Exercise-induced myalgia (HP:0003738)2.07679502
59Cutaneous finger syndactyly (HP:0010554)2.07484599
60Bundle branch block (HP:0011710)2.05045249
61Neurofibrillary tangles (HP:0002185)2.04747871
62Insomnia (HP:0100785)2.02915559
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.02812982
64Abnormality of the labia minora (HP:0012880)2.02630959
65Hyperacusis (HP:0010780)2.02078277
66Central scotoma (HP:0000603)1.99840099
67Genetic anticipation (HP:0003743)1.99734771
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99585617
69Pheochromocytoma (HP:0002666)1.98534317
70Abnormality of the corticospinal tract (HP:0002492)1.98427835
71Abnormality of oral frenula (HP:0000190)1.97318145
72Sudden death (HP:0001699)1.96594286
73Anosmia (HP:0000458)1.96372759
74Renal hypoplasia (HP:0000089)1.96368248
75Cortical dysplasia (HP:0002539)1.96049302
76Primary atrial arrhythmia (HP:0001692)1.95304058
77Poor eye contact (HP:0000817)1.90252123
78Abnormality of the 4th metacarpal (HP:0010012)1.89474274
79Unilateral renal agenesis (HP:0000122)1.88730382
80Obstructive sleep apnea (HP:0002870)1.88687880
81Torticollis (HP:0000473)1.88675413
82Pointed chin (HP:0000307)1.87166450
83Atrial fibrillation (HP:0005110)1.86758878
84Excessive salivation (HP:0003781)1.85657705
85Cutaneous syndactyly (HP:0012725)1.85520024
86Hemivertebrae (HP:0002937)1.84712659
87Supernumerary ribs (HP:0005815)1.84057963
88Supraventricular tachycardia (HP:0004755)1.83921156
89Status epilepticus (HP:0002133)1.83306156
90Morphological abnormality of the inner ear (HP:0011390)1.82219095
91Bronchomalacia (HP:0002780)1.82175366
92Thickened helices (HP:0000391)1.81170297
93Urinary urgency (HP:0000012)1.81095534
94Renal duplication (HP:0000075)1.80581087
95Midline defect of the nose (HP:0004122)1.79768655
96Renovascular hypertension (HP:0100817)1.79482337
97Truncal ataxia (HP:0002078)1.79327700
98Trigonocephaly (HP:0000243)1.79013519
99Large for gestational age (HP:0001520)1.77006018
100Down-sloping shoulders (HP:0200021)1.76975292
101Supraventricular arrhythmia (HP:0005115)1.76546177
102Postural instability (HP:0002172)1.75954089
103Turricephaly (HP:0000262)1.74929279
104Gaze-evoked nystagmus (HP:0000640)1.74719499
105Choanal stenosis (HP:0000452)1.74391140
106Increased nuchal translucency (HP:0010880)1.73954330
107Maternal diabetes (HP:0009800)1.72978388
108Generalized tonic-clonic seizures (HP:0002069)1.72478208
109Impaired social interactions (HP:0000735)1.72274452
110Abnormal social behavior (HP:0012433)1.72274452
111Macroorchidism (HP:0000053)1.72180092
112Optic nerve hypoplasia (HP:0000609)1.72021366
113Papilledema (HP:0001085)1.71755177
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70661766
115Gastrointestinal atresia (HP:0002589)1.69501176
116Obsessive-compulsive behavior (HP:0000722)1.68540561
117Mixed hearing impairment (HP:0000410)1.68070897
118Stereotypic behavior (HP:0000733)1.67296985
119Abnormality of the intervertebral disk (HP:0005108)1.67054009
120Short 4th metacarpal (HP:0010044)1.66171521
121Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66171521
122Hyperthyroidism (HP:0000836)1.65742644
123Growth hormone deficiency (HP:0000824)1.65204548
124Heart block (HP:0012722)1.64502711
125Double outlet right ventricle (HP:0001719)1.64136465
126Congenital malformation of the right heart (HP:0011723)1.64136465
127Cerebral hypomyelination (HP:0006808)1.64051478
128Abnormality of the antihelix (HP:0009738)1.63750920
129Anteriorly placed anus (HP:0001545)1.63461128
130Rib fusion (HP:0000902)1.62425323
131Overriding aorta (HP:0002623)1.61839793
132Dysmetria (HP:0001310)1.61441531
133Deep palmar crease (HP:0006191)1.61020583
134Difficulty running (HP:0009046)1.60980584
135Esophageal atresia (HP:0002032)1.60376487
136Oligodactyly (hands) (HP:0001180)1.60225100
137Absent septum pellucidum (HP:0001331)1.59164718
138Amblyopia (HP:0000646)1.58325686
139Scotoma (HP:0000575)1.58054570
140Flat cornea (HP:0007720)1.57656707
141Hyperventilation (HP:0002883)1.57495683
142Exotropia (HP:0000577)1.57401259
143Hypoventilation (HP:0002791)1.57384725
144Autism (HP:0000717)1.57181720
145Epileptiform EEG discharges (HP:0011182)1.57082742
146Elfin facies (HP:0004428)1.56801275
147Abnormality of the parathyroid morphology (HP:0011766)1.56642885
148Narrow nasal bridge (HP:0000446)1.56249458
149Hamartoma (HP:0010566)1.55799131
150Urinary bladder sphincter dysfunction (HP:0002839)1.54769541
151Intention tremor (HP:0002080)1.54511818
152Hypsarrhythmia (HP:0002521)1.54231792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.45077345
2NTRK33.74519491
3ICK2.88984438
4EPHB22.65548514
5PINK12.49355833
6UHMK12.42982895
7NTRK22.35165137
8MAPK152.24956405
9PRPF4B2.16747676
10TNIK2.13839382
11DYRK21.99107417
12MARK11.98758807
13MAP3K91.95773918
14TYRO31.94743391
15PNCK1.92560016
16PHKG21.82162198
17PHKG11.82162198
18MAP3K41.79527796
19PRKD31.78684270
20MINK11.74795315
21KSR11.65665283
22PAK61.65476670
23DDR21.61829171
24SIK21.51976975
25CAMK1G1.48944132
26NTRK11.47272000
27LMTK21.45766403
28DAPK21.43083972
29PRKD21.42064450
30DAPK11.37202131
31CDC42BPA1.34638973
32CAMKK11.32345913
33PLK21.32003511
34STK381.28007633
35CAMK1D1.26032894
36PKN11.21924584
37CDK51.21528721
38DYRK1B1.18901930
39MAP2K71.16922475
40MAP3K101.16194367
41MAP3K61.15159140
42PDGFRA1.11501725
43SGK21.00768207
44SGK4941.00555259
45SGK2231.00555259
46LATS20.98404477
47BRSK10.96999258
48KSR20.95864157
49CSNK1G20.94296156
50PRKCH0.91697382
51TRIB30.91544729
52BCR0.91475756
53MARK20.90130207
54CDK190.89190486
55RIPK10.87869058
56ERBB30.87447082
57SGK10.85966025
58LATS10.85158225
59CAMK2B0.84769522
60SIK30.84362433
61IRAK20.82686600
62DMPK0.82661894
63CAMK2A0.82079256
64FGR0.81894626
65INSRR0.81089490
66SGK30.79251929
67MAP2K40.78746578
68HIPK20.78436756
69PAK30.78232268
70MAPK130.78085407
71EEF2K0.76804788
72ARAF0.73955918
73FES0.72450924
74MUSK0.70537541
75TAOK20.69139223
76ROCK20.66328790
77CAMK10.64460894
78CASK0.63244126
79PRKCG0.62757034
80GSK3A0.61810850
81CAMK2D0.61649036
82STK110.58800279
83MATK0.58189995
84CAMK40.56935456
85YES10.56885435
86CAMK2G0.56503540
87FER0.56480861
88MKNK20.56438798
89FGFR20.55781150
90CSNK1E0.55670626
91PRKAA10.55512523
92CDK180.55076454
93GRK50.54829766
94RPS6KA30.54828031
95CDK140.54784398
96MKNK10.54513048
97WNK10.54418932
98ERBB20.54006131
99CDK150.53944380
100BRAF0.52522241
101RIPK40.52406003
102TNK20.52147743
103MAP3K20.52140394
104DYRK1A0.50778498
105MAP3K120.49666498
106CSNK1G30.49121468
107RAF10.48876638
108TAOK10.48865865
109WNK40.48840392
110FGFR10.48683629
111ALK0.48303990
112CDK11A0.48303932
113PRKCE0.48302219
114CDC70.48129208
115RPS6KA20.47026033
116PRKDC0.46698569
117MAPK100.46196975
118CDK30.44576873
119CSNK1G10.44497371
120GSK3B0.44481370
121LIMK10.44200767
122CSNK1A1L0.44113962
123DYRK30.44040544
124PRKCZ0.43891525
125SIK10.43553069
126MAPK110.41888044
127RPS6KC10.41676707
128RPS6KL10.41676707
129NEK60.41287873
130CSNK1D0.41284365
131MAPK80.37641337
132PLK30.35489385
133ROCK10.34487734
134CDK10.32813061
135CDK20.31270968
136BRD40.31097751
137PRKG10.28818205

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.78238119
2Olfactory transduction_Homo sapiens_hsa047402.76234818
3Circadian entrainment_Homo sapiens_hsa047132.48641960
4GABAergic synapse_Homo sapiens_hsa047272.33036928
5Morphine addiction_Homo sapiens_hsa050322.28830142
6Synaptic vesicle cycle_Homo sapiens_hsa047212.23862496
7Glutamatergic synapse_Homo sapiens_hsa047242.22657420
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09590960
9Amphetamine addiction_Homo sapiens_hsa050312.07569700
10Long-term potentiation_Homo sapiens_hsa047202.03473133
11Dopaminergic synapse_Homo sapiens_hsa047281.93659268
12Cholinergic synapse_Homo sapiens_hsa047251.82765078
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79341164
14Cocaine addiction_Homo sapiens_hsa050301.78579464
15Insulin secretion_Homo sapiens_hsa049111.75751470
16Phototransduction_Homo sapiens_hsa047441.73992454
17Taste transduction_Homo sapiens_hsa047421.69829674
18Axon guidance_Homo sapiens_hsa043601.62334727
19Circadian rhythm_Homo sapiens_hsa047101.61962367
20Gastric acid secretion_Homo sapiens_hsa049711.59203125
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55970267
22Salivary secretion_Homo sapiens_hsa049701.55812589
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51589014
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51325477
25Renin secretion_Homo sapiens_hsa049241.50314222
26Calcium signaling pathway_Homo sapiens_hsa040201.50167705
27Serotonergic synapse_Homo sapiens_hsa047261.49101777
28Oxytocin signaling pathway_Homo sapiens_hsa049211.46313811
29GnRH signaling pathway_Homo sapiens_hsa049121.45167051
30Long-term depression_Homo sapiens_hsa047301.40610214
31Gap junction_Homo sapiens_hsa045401.40337993
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30370978
33Notch signaling pathway_Homo sapiens_hsa043301.28068524
34cAMP signaling pathway_Homo sapiens_hsa040241.26197357
35Melanogenesis_Homo sapiens_hsa049161.24467418
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23728008
37Dilated cardiomyopathy_Homo sapiens_hsa054141.22672199
38Dorso-ventral axis formation_Homo sapiens_hsa043201.21576561
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21106189
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17139623
41ErbB signaling pathway_Homo sapiens_hsa040121.13706871
42Fatty acid biosynthesis_Homo sapiens_hsa000611.12515613
43Wnt signaling pathway_Homo sapiens_hsa043101.11718517
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08931958
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07787088
46Hippo signaling pathway_Homo sapiens_hsa043901.07715063
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04657640
48Glioma_Homo sapiens_hsa052141.04600062
49Hedgehog signaling pathway_Homo sapiens_hsa043401.04395798
50Estrogen signaling pathway_Homo sapiens_hsa049151.04192985
51Type II diabetes mellitus_Homo sapiens_hsa049301.02594763
52Basal cell carcinoma_Homo sapiens_hsa052171.01013561
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99397880
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96782966
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93746842
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92678677
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92442482
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91438235
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.88009391
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87181945
61MAPK signaling pathway_Homo sapiens_hsa040100.86142131
62VEGF signaling pathway_Homo sapiens_hsa043700.85427894
63mTOR signaling pathway_Homo sapiens_hsa041500.84686101
64Bile secretion_Homo sapiens_hsa049760.83883411
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83311911
66Oocyte meiosis_Homo sapiens_hsa041140.82553399
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79526385
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79299412
69Vitamin B6 metabolism_Homo sapiens_hsa007500.78831689
70Cardiac muscle contraction_Homo sapiens_hsa042600.78582783
71Endometrial cancer_Homo sapiens_hsa052130.77585758
72Ras signaling pathway_Homo sapiens_hsa040140.77429335
73Choline metabolism in cancer_Homo sapiens_hsa052310.75281321
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73182284
75Rap1 signaling pathway_Homo sapiens_hsa040150.72838563
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.72364724
77Prion diseases_Homo sapiens_hsa050200.69383554
78Tight junction_Homo sapiens_hsa045300.66262743
79Alzheimers disease_Homo sapiens_hsa050100.63908643
80Non-small cell lung cancer_Homo sapiens_hsa052230.63737938
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.63101232
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62928892
83Pancreatic secretion_Homo sapiens_hsa049720.60536570
84Glucagon signaling pathway_Homo sapiens_hsa049220.60523203
85Collecting duct acid secretion_Homo sapiens_hsa049660.59736836
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59696659
87Insulin signaling pathway_Homo sapiens_hsa049100.58877562
88Parkinsons disease_Homo sapiens_hsa050120.56799202
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51886113
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51019634
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.50753098
92Thyroid hormone synthesis_Homo sapiens_hsa049180.49342714
93MicroRNAs in cancer_Homo sapiens_hsa052060.49088719
94Endocytosis_Homo sapiens_hsa041440.48656440
95Inositol phosphate metabolism_Homo sapiens_hsa005620.47923531
96Alcoholism_Homo sapiens_hsa050340.47665292
97mRNA surveillance pathway_Homo sapiens_hsa030150.45596271
98Vibrio cholerae infection_Homo sapiens_hsa051100.45172699
99Chemokine signaling pathway_Homo sapiens_hsa040620.43341773
100Renal cell carcinoma_Homo sapiens_hsa052110.42461567
101Arginine and proline metabolism_Homo sapiens_hsa003300.42129878
102Bladder cancer_Homo sapiens_hsa052190.41952081
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41896822
104Lysine degradation_Homo sapiens_hsa003100.41809563
105Colorectal cancer_Homo sapiens_hsa052100.41349166
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39878571
107Ovarian steroidogenesis_Homo sapiens_hsa049130.39520917
108Proteoglycans in cancer_Homo sapiens_hsa052050.39039823
109Adherens junction_Homo sapiens_hsa045200.38610309
110Prolactin signaling pathway_Homo sapiens_hsa049170.38549415
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38166051
112Focal adhesion_Homo sapiens_hsa045100.37072771
113Huntingtons disease_Homo sapiens_hsa050160.36754480
114Oxidative phosphorylation_Homo sapiens_hsa001900.35599567
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29577910

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