RHBDF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.41789660
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.41789660
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.41789660
4modulation by symbiont of host immune response (GO:0052553)5.41789660
5positive regulation by symbiont of host defense response (GO:0052509)5.41789660
6modulation by symbiont of host defense response (GO:0052031)5.41789660
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.95513197
8negative regulation of cell killing (GO:0031342)4.95513197
9response to peptidoglycan (GO:0032494)4.78056082
10neutrophil activation involved in immune response (GO:0002283)4.60826159
11positive regulation of interferon-alpha production (GO:0032727)4.55279048
12regulation of interferon-alpha production (GO:0032647)4.34857870
13response to muramyl dipeptide (GO:0032495)4.18613223
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.11013842
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.11013842
16positive regulation of chemokine biosynthetic process (GO:0045080)4.04722001
17immunoglobulin mediated immune response (GO:0016064)4.04708445
18antigen processing and presentation of endogenous antigen (GO:0019883)3.97049108
19regulation of interferon-beta biosynthetic process (GO:0045357)3.96746760
20macrophage activation involved in immune response (GO:0002281)3.95001964
21detection of other organism (GO:0098543)3.93992626
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.91919982
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.89338526
24detection of bacterium (GO:0016045)3.86182382
25response to host immune response (GO:0052572)3.75740780
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.75740780
27positive regulation of gamma-delta T cell activation (GO:0046645)3.75248018
28granulocyte activation (GO:0036230)3.64688979
29leukocyte aggregation (GO:0070486)3.55376644
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.48300474
31response to host (GO:0075136)3.48300474
32response to host defenses (GO:0052200)3.48300474
33regulation of B cell receptor signaling pathway (GO:0050855)3.46977473
34neutrophil activation (GO:0042119)3.46965137
35detection of external biotic stimulus (GO:0098581)3.44831088
36respiratory burst (GO:0045730)3.42883901
37positive regulation of interferon-beta production (GO:0032728)3.42360160
38regulation of antigen processing and presentation (GO:0002577)3.42311048
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37588314
40response to type I interferon (GO:0034340)3.36313692
41type I interferon signaling pathway (GO:0060337)3.35342798
42cellular response to type I interferon (GO:0071357)3.35342798
43positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.29782099
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27916108
45negative regulation of cytokine production involved in immune response (GO:0002719)3.26560310
46interferon-gamma-mediated signaling pathway (GO:0060333)3.23334699
47regulation of chemokine biosynthetic process (GO:0045073)3.22507805
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.19476323
49positive regulation of heat generation (GO:0031652)3.19413180
50hydrogen peroxide biosynthetic process (GO:0050665)3.17928048
51T-helper 1 type immune response (GO:0042088)3.16350131
52regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10225077
53positive regulation of type 2 immune response (GO:0002830)3.09833070
54regulation of T cell tolerance induction (GO:0002664)3.08053733
55B cell mediated immunity (GO:0019724)3.07228711
56cellular response to virus (GO:0098586)3.06904194
57natural killer cell mediated cytotoxicity (GO:0042267)3.06522396
58natural killer cell mediated immunity (GO:0002228)3.06522396
59detection of biotic stimulus (GO:0009595)3.05263977
60positive regulation of cellular amide metabolic process (GO:0034250)3.04653411
61negative regulation of lymphocyte mediated immunity (GO:0002707)3.03343020
62negative regulation of T cell mediated immunity (GO:0002710)3.02062085
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00511605
64positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00314414
65regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99653791
66NIK/NF-kappaB signaling (GO:0038061)2.99019542
67positive regulation of antigen processing and presentation (GO:0002579)2.96679507
68T cell migration (GO:0072678)2.95125711
69myeloid cell activation involved in immune response (GO:0002275)2.94052316
70cytokine secretion (GO:0050663)2.93403313
71regulation of fever generation (GO:0031620)2.92625685
72regulation of T cell mediated cytotoxicity (GO:0001914)2.92552877
73regulation of T-helper 1 cell differentiation (GO:0045625)2.92023939
74negative regulation of interleukin-12 production (GO:0032695)2.91828186
75regulation of podosome assembly (GO:0071801)2.91201502
76production of molecular mediator involved in inflammatory response (GO:0002532)2.91112056
77regulation of interleukin-12 production (GO:0032655)2.90663962
78negative regulation of leukocyte mediated immunity (GO:0002704)2.90385904
79negative regulation of innate immune response (GO:0045824)2.90127375
80regulation of gamma-delta T cell differentiation (GO:0045586)2.88884352
81regulation of T-helper 2 cell differentiation (GO:0045628)2.84565585
82defense response to protozoan (GO:0042832)2.84453062
83response to interferon-alpha (GO:0035455)2.84344173
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83004911
85B cell receptor signaling pathway (GO:0050853)2.81089022
86positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80068671
87reactive oxygen species biosynthetic process (GO:1903409)2.79801763
88regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78202226
89regulation of vitamin D biosynthetic process (GO:0060556)2.77662477
90myeloid dendritic cell differentiation (GO:0043011)2.77659603
91cellular extravasation (GO:0045123)2.77177277
92regulation of tolerance induction (GO:0002643)2.76831981
93regulation of mast cell activation (GO:0033003)2.76687492
94regulation of hypersensitivity (GO:0002883)2.76638179
95positive regulation of mast cell degranulation (GO:0043306)2.76373317
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.76373317
97positive regulation of interleukin-17 production (GO:0032740)2.75187799
98positive regulation of interleukin-12 production (GO:0032735)2.74294462
99I-kappaB phosphorylation (GO:0007252)2.74277130
100positive regulation of defense response to virus by host (GO:0002230)2.73762301
101JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.73682625
102regulation of mast cell activation involved in immune response (GO:0033006)2.73669622
103positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73289934
104positive thymic T cell selection (GO:0045059)2.72414056
105positive regulation of T cell mediated cytotoxicity (GO:0001916)2.72392961
106leukocyte cell-cell adhesion (GO:0007159)2.71383175
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70376474
108response to protozoan (GO:0001562)2.70154039
109regulation of gamma-delta T cell activation (GO:0046643)2.70127048
110response to interferon-gamma (GO:0034341)2.69930788
111microglial cell activation (GO:0001774)2.69439854
112regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.69329192
113positive regulation of B cell differentiation (GO:0045579)2.68843876
114regulation of mast cell degranulation (GO:0043304)2.68811897
115negative regulation of interleukin-6 production (GO:0032715)2.68672162
116germinal center formation (GO:0002467)2.68144325
117myeloid dendritic cell activation (GO:0001773)2.66687966
118positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.66079101
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.65407263
120negative regulation of viral genome replication (GO:0045071)2.65156538
121low-density lipoprotein particle clearance (GO:0034383)2.64947649
122positive regulation of mast cell activation (GO:0033005)2.64928981
123positive regulation of NF-kappaB import into nucleus (GO:0042346)2.63885737
124regulation of interferon-beta production (GO:0032648)2.63307583
125regulation of heterotypic cell-cell adhesion (GO:0034114)2.61084739
126macrophage activation (GO:0042116)2.60857396
127regulation of integrin activation (GO:0033623)2.60295814
128positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.59920152
129superoxide anion generation (GO:0042554)2.59539944
130positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.59235034
131positive regulation of tumor necrosis factor production (GO:0032760)2.56970774
132positive regulation of chemokine production (GO:0032722)2.56663676
133positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.56144919
134positive regulation of cytokine biosynthetic process (GO:0042108)2.56063033
135cellular response to interferon-beta (GO:0035458)2.55838615
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.55738068
137detection of molecule of bacterial origin (GO:0032490)2.55187662
138cellular response to interferon-gamma (GO:0071346)2.54921086
139regulation of cholesterol storage (GO:0010885)2.54742272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.25260882
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.77239637
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.55813677
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.15585828
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.46325001
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.31284406
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.21374872
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17589585
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09361758
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.96561027
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96320192
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87984839
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.87030458
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69190794
15* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66660972
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56627003
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46393356
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.45344827
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27678622
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23187463
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14406644
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08753390
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05669562
24* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05401980
25VDR_21846776_ChIP-Seq_THP-1_Human2.01037775
26MAF_26560356_Chip-Seq_TH1_Human1.86169401
27SPI1_23547873_ChIP-Seq_NB4_Human1.78977745
28VDR_24763502_ChIP-Seq_THP-1_Human1.78624980
29SCL_19346495_ChIP-Seq_HPC-7_Human1.77550432
30* MYC_22102868_ChIP-Seq_BL_Human1.77475373
31MYB_26560356_Chip-Seq_TH2_Human1.67872110
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63853396
33* TCF7_22412390_ChIP-Seq_EML_Mouse1.62061846
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.61044474
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57855092
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56049834
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.54163741
38MYB_26560356_Chip-Seq_TH1_Human1.51854944
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50293250
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49551872
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48033474
42UTX_26944678_Chip-Seq_JUKART_Human1.44796883
43PU_27001747_Chip-Seq_BMDM_Mouse1.44668924
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.43815319
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41611399
46RUNX_20019798_ChIP-Seq_JUKART_Human1.41446315
47GATA1_22025678_ChIP-Seq_K562_Human1.40358363
48SPI1_23127762_ChIP-Seq_K562_Human1.40103078
49BCL6_27268052_Chip-Seq_Bcells_Human1.38484324
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37462234
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35916524
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35035614
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34638879
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31966609
55E2F7_22180533_ChIP-Seq_HELA_Human1.30559198
56BCOR_27268052_Chip-Seq_Bcells_Human1.28356945
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27969109
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25659786
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25324682
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25166684
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.23686351
62* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22733140
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22597776
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22417462
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20771945
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20567957
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20567957
68* KDM2B_26808549_Chip-Seq_DND41_Human1.17849049
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16923521
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16057990
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15073300
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14882249
73GATA3_26560356_Chip-Seq_TH2_Human1.13422242
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13317336
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.11368855
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.10522724
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10509274
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09958412
79MAF_26560356_Chip-Seq_TH2_Human1.09860805
80* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09637600
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09437611
82* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09017670
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.08558131
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06787633
85VDR_24787735_ChIP-Seq_THP-1_Human1.06648701
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04390013
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.03299628
88* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02478602
89GATA1_19941826_ChIP-Seq_K562_Human1.02152316
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.02105059
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02086421
92GATA3_27048872_Chip-Seq_THYMUS_Human1.01535470
93* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00618914
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99930673
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99685226
96* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99424986
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97977936
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.97486343
99RACK7_27058665_Chip-Seq_MCF-7_Human0.97054461
100* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96754786
101P68_20966046_ChIP-Seq_HELA_Human0.96636150
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96309395
103CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96267924
104* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95965140
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94738207
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94622944
107STAT1_20625510_ChIP-Seq_HELA_Human0.92789976
108* ATF3_27146783_Chip-Seq_COLON_Human0.92639104
109NCOR1_26117541_ChIP-Seq_K562_Human0.92506013
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92037099
111* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91645073
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91441083
113LXR_22292898_ChIP-Seq_THP-1_Human0.91286655
114SA1_27219007_Chip-Seq_ERYTHROID_Human0.90813138
115CLOCK_20551151_ChIP-Seq_293T_Human0.90361708
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90151079
117ESR2_21235772_ChIP-Seq_MCF-7_Human0.89023012
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88192839
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88149696
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87594515
121RXR_22158963_ChIP-Seq_LIVER_Mouse0.87242992
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86226925
123GATA6_25053715_ChIP-Seq_YYC3_Human0.85905527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.47666263
2MP0003303_peritoneal_inflammation3.44732107
3MP0003436_decreased_susceptibility_to3.40606618
4MP0009785_altered_susceptibility_to3.18214918
5MP0002148_abnormal_hypersensitivity_rea2.68056754
6MP0005000_abnormal_immune_tolerance2.63119655
7MP0005387_immune_system_phenotype2.61349403
8MP0001790_abnormal_immune_system2.61349403
9MP0002419_abnormal_innate_immunity2.56020557
10MP0000685_abnormal_immune_system2.55299658
11MP0005025_abnormal_response_to2.52489167
12MP0004947_skin_inflammation2.49349861
13MP0001800_abnormal_humoral_immune2.35298716
14MP0002452_abnormal_antigen_presenting2.32316712
15MP0003724_increased_susceptibility_to2.26358748
16MP0004510_myositis2.23943929
17MP0009278_abnormal_bone_marrow2.22377052
18MP0006082_CNS_inflammation2.18454178
19MP0002723_abnormal_immune_serum2.15355149
20MP0003300_gastrointestinal_ulcer1.94377400
21MP0001819_abnormal_immune_cell1.93071763
22MP0002420_abnormal_adaptive_immunity1.90571216
23MP0001853_heart_inflammation1.88773301
24MP0005671_abnormal_response_to1.87311196
25MP0002006_tumorigenesis1.84270770
26MP0003448_altered_tumor_morphology1.78274974
27MP0005464_abnormal_platelet_physiology1.76609163
28MP0002405_respiratory_system_inflammati1.75449059
29MP0009764_decreased_sensitivity_to1.75129079
30MP0001533_abnormal_skeleton_physiology1.74430600
31MP0005076_abnormal_cell_differentiation1.74230677
32MP0003566_abnormal_cell_adhesion1.72749543
33MP0005397_hematopoietic_system_phenotyp1.70292681
34MP0001545_abnormal_hematopoietic_system1.70292681
35MP0001845_abnormal_inflammatory_respons1.69888261
36MP0005058_abnormal_lysosome_morphology1.69707743
37MP0010155_abnormal_intestine_physiology1.68483891
38MP0003453_abnormal_keratinocyte_physiol1.68209634
39MP0000858_altered_metastatic_potential1.66999320
40MP0010352_gastrointestinal_tract_polyps1.64262670
41MP0002254_reproductive_system_inflammat1.62604999
42MP0009840_abnormal_foam_cell1.58267779
43MP0000343_altered_response_to1.52549290
44MP0003705_abnormal_hypodermis_morpholog1.52007123
45MP0002398_abnormal_bone_marrow1.48154575
46MP0002166_altered_tumor_susceptibility1.47992842
47MP0000716_abnormal_immune_system1.45160110
48MP0009333_abnormal_splenocyte_physiolog1.44905134
49MP0008469_abnormal_protein_level1.44459763
50MP0003191_abnormal_cellular_cholesterol1.44019396
51MP0005167_abnormal_blood-brain_barrier1.41290168
52MP0010307_abnormal_tumor_latency1.38907420
53MP0003183_abnormal_peptide_metabolism1.32485371
54MP0000689_abnormal_spleen_morphology1.30093585
55MP0010234_abnormal_vibrissa_follicle1.23969211
56MP0005023_abnormal_wound_healing1.23691343
57MP0002722_abnormal_immune_system1.23458995
58MP0002429_abnormal_blood_cell1.20729690
59MP0003828_pulmonary_edema1.17336731
60MP0003172_abnormal_lysosome_physiology1.15235784
61MP0004782_abnormal_surfactant_physiolog1.11934386
62MP0003075_altered_response_to1.11010253
63MP0005166_decreased_susceptibility_to1.08245550
64MP0008004_abnormal_stomach_pH1.07781793
65MP0003690_abnormal_glial_cell1.07174315
66MP0003866_abnormal_defecation1.06949799
67MP0001873_stomach_inflammation1.05752123
68MP0002998_abnormal_bone_remodeling1.04983694
69MP0002796_impaired_skin_barrier1.04103044
70MP0003806_abnormal_nucleotide_metabolis1.04092615
71MP0005310_abnormal_salivary_gland1.04014052
72MP0001216_abnormal_epidermal_layer1.03446783
73MP0003763_abnormal_thymus_physiology1.01637855
74MP0004808_abnormal_hematopoietic_stem1.00462253
75MP0003195_calcinosis1.00326846
76MP0002332_abnormal_exercise_endurance0.99789821
77MP0004883_abnormal_blood_vessel0.99759249
78MP0009763_increased_sensitivity_to0.95985109
79MP0001851_eye_inflammation0.95014858
80MP0002138_abnormal_hepatobiliary_system0.93593965
81MP0003091_abnormal_cell_migration0.93313479
82MP0005390_skeleton_phenotype0.90823974
83MP0001663_abnormal_digestive_system0.90583686
84MP0000490_abnormal_crypts_of0.90166331
85MP0000604_amyloidosis0.88762608
86MP0002139_abnormal_hepatobiliary_system0.86749486
87MP0002060_abnormal_skin_morphology0.84078829
88MP0002933_joint_inflammation0.82711301
89MP0000465_gastrointestinal_hemorrhage0.81622589
90MP0005164_abnormal_response_to0.78074813
91MP0004381_abnormal_hair_follicle0.77163040
92MP0005083_abnormal_biliary_tract0.76513420
93MP0002136_abnormal_kidney_physiology0.75455527
94MP0005451_abnormal_body_composition0.75435058
95MP0000703_abnormal_thymus_morphology0.74563467
96MP0000249_abnormal_blood_vessel0.74464162
97MP0009931_abnormal_skin_appearance0.74365467
98MP0002277_abnormal_respiratory_mucosa0.74188711
99MP0000767_abnormal_smooth_muscle0.73655734
100MP0005501_abnormal_skin_physiology0.73259436
101MP0001191_abnormal_skin_condition0.72479428
102MP0002132_abnormal_respiratory_system0.71577421
103MP0000609_abnormal_liver_physiology0.68439535
104MP0003186_abnormal_redox_activity0.68247921
105MP0005275_abnormal_skin_tensile0.68182220
106MP0002019_abnormal_tumor_incidence0.68116521
107MP0001986_abnormal_taste_sensitivity0.67983347
108MP0003045_fibrosis0.67835412
109MP0002098_abnormal_vibrissa_morphology0.66989545
110MP0002396_abnormal_hematopoietic_system0.66313563
111MP0008260_abnormal_autophagy0.66034647
112MP0000569_abnormal_digit_pigmentation0.65921869
113MP0001958_emphysema0.65815852
114MP0003656_abnormal_erythrocyte_physiolo0.65332847
115MP0009765_abnormal_xenobiotic_induced0.65012395
116MP0003795_abnormal_bone_structure0.64206866
117MP0008874_decreased_physiological_sensi0.63084690
118MP0002693_abnormal_pancreas_physiology0.58704351
119MP0003646_muscle_fatigue0.58608772
120MP0000015_abnormal_ear_pigmentation0.58225259
121MP0005319_abnormal_enzyme/_coenzyme0.53158114
122MP0005381_digestive/alimentary_phenotyp0.51325774

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.03387685
2Recurrent abscess formation (HP:0002722)5.92393007
3Recurrent bacterial skin infections (HP:0005406)5.42801215
4Recurrent gram-negative bacterial infections (HP:0005420)4.66855364
5Elevated erythrocyte sedimentation rate (HP:0003565)4.31881540
6Abnormality of macrophages (HP:0004311)4.10681942
7Autoimmune thrombocytopenia (HP:0001973)4.06603767
8* Mediastinal lymphadenopathy (HP:0100721)3.91044563
9Myositis (HP:0100614)3.83544912
10Stomatitis (HP:0010280)3.76713580
11Orchitis (HP:0100796)3.75193115
12Interstitial pulmonary disease (HP:0006530)3.71159046
13Pustule (HP:0200039)3.53443198
14Gingivitis (HP:0000230)3.50647046
15Recurrent fungal infections (HP:0002841)3.44712769
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.36171923
17Cellulitis (HP:0100658)3.32242364
18Recurrent skin infections (HP:0001581)3.29343978
19Vasculitis (HP:0002633)3.28640621
20Dysostosis multiplex (HP:0000943)3.18465772
21Retrobulbar optic neuritis (HP:0100654)3.16409495
22Optic neuritis (HP:0100653)3.16409495
23Recurrent viral infections (HP:0004429)3.14996326
24Encephalitis (HP:0002383)3.08475678
25Vacuolated lymphocytes (HP:0001922)3.07209522
26Periodontitis (HP:0000704)3.06055536
27Increased cerebral lipofuscin (HP:0011813)2.99974876
28Systemic lupus erythematosus (HP:0002725)2.99092307
29Hematochezia (HP:0002573)2.95439885
30Chronic otitis media (HP:0000389)2.93269486
31Urticaria (HP:0001025)2.85050473
32Obstructive lung disease (HP:0006536)2.79013422
33Chronic obstructive pulmonary disease (HP:0006510)2.79013422
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73773364
35Thick nail (HP:0001805)2.72666674
36Myocardial infarction (HP:0001658)2.72433302
37T lymphocytopenia (HP:0005403)2.69075525
38Nasal polyposis (HP:0100582)2.68666844
39Abnormality of the nasal mucosa (HP:0000433)2.67653014
40Panhypogammaglobulinemia (HP:0003139)2.65393597
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.65292169
42Tetraparesis (HP:0002273)2.60186098
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60059570
44Abnormality of polysaccharide metabolism (HP:0011012)2.60059570
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60059570
46Increased IgE level (HP:0003212)2.58590007
47Abnormality of T cell number (HP:0011839)2.56666744
48Osteomyelitis (HP:0002754)2.55293896
49Premature loss of primary teeth (HP:0006323)2.46288710
50Axonal loss (HP:0003447)2.46256195
51Pulmonary infiltrates (HP:0002113)2.41297712
52Urinary glycosaminoglycan excretion (HP:0003541)2.40481290
53Mucopolysacchariduria (HP:0008155)2.40481290
54Colitis (HP:0002583)2.38653015
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.38027769
56Osteolytic defects of the hand bones (HP:0009699)2.38027769
57Chest pain (HP:0100749)2.38025529
58Meningitis (HP:0001287)2.37793211
59Basal ganglia calcification (HP:0002135)2.36332410
60Pulmonary embolism (HP:0002204)2.32887921
61Arterial thrombosis (HP:0004420)2.32578591
62Recurrent cutaneous fungal infections (HP:0011370)2.30485153
63Chronic mucocutaneous candidiasis (HP:0002728)2.30485153
64Malnutrition (HP:0004395)2.28943283
65Skin ulcer (HP:0200042)2.28901078
66Episodic fever (HP:0001954)2.27878333
67Abnormality of T cells (HP:0002843)2.27875799
68Mutism (HP:0002300)2.27829439
69Purpura (HP:0000979)2.27346055
70Spontaneous hematomas (HP:0007420)2.27213196
71Emphysema (HP:0002097)2.26819376
72Leukocytosis (HP:0001974)2.25329826
73Prolonged bleeding time (HP:0003010)2.24318176
74Recurrent bronchitis (HP:0002837)2.23045051
75Abnormality of the pleura (HP:0002103)2.22688383
76Recurrent pneumonia (HP:0006532)2.21784198
77Gingival bleeding (HP:0000225)2.21564363
78Gastrointestinal stroma tumor (HP:0100723)2.15182003
79Hypergammaglobulinemia (HP:0010702)2.14880790
80Disinhibition (HP:0000734)2.14725846
81Nephritis (HP:0000123)2.13799044
82Esophageal varix (HP:0002040)2.13340712
83Inflammation of the large intestine (HP:0002037)2.13080064
84Increased IgM level (HP:0003496)2.12531636
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08593685
86Keratoconjunctivitis sicca (HP:0001097)2.07714296
87Abnormality of the endocardium (HP:0004306)2.06240527
88Increased serum ferritin (HP:0003281)2.06179968
89Gastrointestinal inflammation (HP:0004386)2.05753143
90Hemoptysis (HP:0002105)2.03347717
91Polyneuropathy (HP:0001271)2.03008467
92Granulocytopenia (HP:0001913)2.01321660
93Recurrent lower respiratory tract infections (HP:0002783)2.01072043
94Glomerulonephritis (HP:0000099)2.00998909
95Peritonitis (HP:0002586)1.99144996
96Neuronal loss in central nervous system (HP:0002529)1.96845900
97Prostate neoplasm (HP:0100787)1.95294341
98Bone pain (HP:0002653)1.95281373
99Gastrointestinal infarctions (HP:0005244)1.95130087
100Glomerulopathy (HP:0100820)1.94739394
101Acne (HP:0001061)1.94116521
102Complement deficiency (HP:0004431)1.92527277
103Keratoconjunctivitis (HP:0001096)1.91035104
104Restrictive lung disease (HP:0002091)1.88803797
105Abnormality of cells of the lymphoid lineage (HP:0012140)1.85578306
106Petechiae (HP:0000967)1.85537584
107Loss of speech (HP:0002371)1.85298256
108Lymphopenia (HP:0001888)1.82934006
109Sepsis (HP:0100806)1.82353850
110Arthralgia (HP:0002829)1.81218385
111Abnormality of the pericardium (HP:0001697)1.81107982
112Abnormality of iron homeostasis (HP:0011031)1.81090329
113Porencephaly (HP:0002132)1.80806844
114Epistaxis (HP:0000421)1.80381244
115Abnormality of the fingertips (HP:0001211)1.80125128
116Pathologic fracture (HP:0002756)1.79055242
117Amyloidosis (HP:0011034)1.78961989
118Cheilitis (HP:0100825)1.78097448
119Abnormality of liposaccharide metabolism (HP:0010968)1.76867199
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.76867199
121Abnormality of glycolipid metabolism (HP:0010969)1.76867199
122Anorexia (HP:0002039)1.75650338
123Joint hemorrhage (HP:0005261)1.74191530
124Hypochromic anemia (HP:0001931)1.71909966
125Vertebral compression fractures (HP:0002953)1.71754140
126Gangrene (HP:0100758)1.71689722
127Agammaglobulinemia (HP:0004432)1.71431128
128Autoimmune hemolytic anemia (HP:0001890)1.71411139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.99170593
2MAP4K13.13877390
3ERN13.08813836
4TBK13.08130202
5TYK22.81394732
6BLK2.67668668
7IRAK32.61770363
8IKBKE2.54410146
9RIPK42.42833934
10IRAK42.29867640
11JAK32.27859488
12IKBKB2.11690556
13CDK122.05173906
14PRPF4B2.01306039
15MAP3K101.95434862
16STK101.87382311
17CHUK1.83566690
18KIT1.82956363
19EPHB11.82162118
20TNK21.78507310
21PIM21.75670976
22JAK11.72573872
23CSK1.64520726
24CDC42BPA1.58672751
25RIPK11.57728314
26GRK71.53797041
27FES1.52675898
28PIM11.52611776
29ZAP701.50389630
30MARK31.47690421
31TAOK21.45373662
32TGFBR21.41905202
33MAP3K31.41366584
34TXK1.38893631
35MST41.34094620
36FGFR41.32467066
37RPS6KA41.30687724
38TRIB31.30584792
39LRRK21.27401646
40BTK1.23843632
41BMX1.22235836
42MAP3K131.21437257
43TTN1.21218793
44TAOK31.17892677
45HCK1.15160852
46PTK61.14141728
47MST1R1.13604822
48EPHA21.10230560
49MAP2K31.04977636
50SYK1.04597629
51CSF1R1.03384979
52JAK21.00825836
53TESK21.00128284
54MATK0.99557298
55FGFR30.96371498
56GRK60.94921076
57MAP3K110.94594148
58IRAK10.93513387
59PRKD20.91571149
60PBK0.91048791
61TRPM70.87856998
62FGR0.86313237
63BMPR20.85144602
64LCK0.83844395
65STK40.83307044
66NME20.82535614
67PDK10.82090703
68MOS0.80251867
69ADRBK20.79811192
70EPHA30.79439183
71CDK60.78971413
72LYN0.78686884
73MARK20.76424466
74TEC0.76382891
75PKN20.74762177
76IRAK20.74734265
77PAK40.74102012
78FLT30.73866403
79EEF2K0.72991352
80PDPK10.70789747
81HIPK20.70515125
82MAP3K50.67519581
83EIF2AK20.67195626
84SIK10.66988387
85DDR20.66742292
86MAPK70.66641444
87NEK90.64988333
88MAP2K60.64474332
89ABL10.63556489
90SMG10.62536792
91STK30.57771377
92MAPK120.57666609
93MAPKAPK20.56750900
94CDK40.55355961
95EGFR0.54354187
96SIK20.54241956
97RPS6KB20.53448278
98NLK0.52789696
99DYRK1B0.51567112
100KDR0.51503026
101PRKCQ0.51406416
102BRSK20.51314123
103ITK0.50523144
104PRKG20.48549216
105MAPKAPK30.47877127
106SIK30.47097287
107CAMK1D0.46860179
108TAOK10.46570311
109FYN0.46437874
110RPS6KA60.46397952
111CLK10.45965681
112ICK0.45920144
113ABL20.45715617
114MAP2K20.41480464
115PRKCD0.40932801
116MAP3K70.40605320
117MAP3K10.39961648
118MAP3K80.38531464
119RPS6KA20.37970508
120RPS6KA10.36462799
121ALK0.36341473
122TESK10.34834482
123MAPK110.34830226
124DAPK30.34616995
125STK240.33077016
126NEK20.31614649
127MAPK40.31573033
128EIF2AK30.31098479
129RPS6KL10.29957426
130RPS6KC10.29957426
131INSR0.27536868
132KSR20.27433616
133YES10.25689802
134DAPK20.25009985
135MAP3K60.23921442

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.30572759
2Graft-versus-host disease_Homo sapiens_hsa053322.85938317
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.71970755
4Staphylococcus aureus infection_Homo sapiens_hsa051502.68912806
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.56003380
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42379092
7Osteoclast differentiation_Homo sapiens_hsa043802.37865041
8Legionellosis_Homo sapiens_hsa051342.36133776
9Malaria_Homo sapiens_hsa051442.22433158
10Measles_Homo sapiens_hsa051622.15779248
11Pertussis_Homo sapiens_hsa051332.14793905
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09424087
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.06409792
14Tuberculosis_Homo sapiens_hsa051522.03544676
15TNF signaling pathway_Homo sapiens_hsa046682.01782993
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00855489
17Influenza A_Homo sapiens_hsa051641.94769817
18B cell receptor signaling pathway_Homo sapiens_hsa046621.84938706
19Allograft rejection_Homo sapiens_hsa053301.83769192
20Toxoplasmosis_Homo sapiens_hsa051451.82221082
21Hematopoietic cell lineage_Homo sapiens_hsa046401.79272178
22Herpes simplex infection_Homo sapiens_hsa051681.77255291
23Antigen processing and presentation_Homo sapiens_hsa046121.65085600
24Asthma_Homo sapiens_hsa053101.64659621
25Apoptosis_Homo sapiens_hsa042101.52767620
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.52543666
27Salmonella infection_Homo sapiens_hsa051321.50863084
28African trypanosomiasis_Homo sapiens_hsa051431.47869777
29Rheumatoid arthritis_Homo sapiens_hsa053231.46536812
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44420978
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.39134374
32Shigellosis_Homo sapiens_hsa051311.34252443
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27657645
34Primary immunodeficiency_Homo sapiens_hsa053401.27163382
35Hepatitis C_Homo sapiens_hsa051601.26362316
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23714683
37Lysosome_Homo sapiens_hsa041421.22514953
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22189899
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.21998586
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21878181
41Amoebiasis_Homo sapiens_hsa051461.18735873
42Type I diabetes mellitus_Homo sapiens_hsa049401.17820741
43Hepatitis B_Homo sapiens_hsa051611.17567084
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14263121
45Acute myeloid leukemia_Homo sapiens_hsa052211.13359959
46Viral myocarditis_Homo sapiens_hsa054161.11447437
47Chemokine signaling pathway_Homo sapiens_hsa040621.07592146
48Small cell lung cancer_Homo sapiens_hsa052221.06825980
49Chronic myeloid leukemia_Homo sapiens_hsa052201.02510789
50Phagosome_Homo sapiens_hsa041451.02368896
51Other glycan degradation_Homo sapiens_hsa005111.02333676
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00938982
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88887286
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.88397484
55T cell receptor signaling pathway_Homo sapiens_hsa046600.87374245
56Caffeine metabolism_Homo sapiens_hsa002320.86495437
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85910943
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.81546602
59Epstein-Barr virus infection_Homo sapiens_hsa051690.78705556
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77354509
61Complement and coagulation cascades_Homo sapiens_hsa046100.76119138
62Pancreatic cancer_Homo sapiens_hsa052120.74288586
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72634852
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72217309
65Notch signaling pathway_Homo sapiens_hsa043300.69609713
66Viral carcinogenesis_Homo sapiens_hsa052030.69131232
67p53 signaling pathway_Homo sapiens_hsa041150.66403609
68MicroRNAs in cancer_Homo sapiens_hsa052060.66273310
69HIF-1 signaling pathway_Homo sapiens_hsa040660.65613619
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.64919514
71Platelet activation_Homo sapiens_hsa046110.64280451
72Insulin resistance_Homo sapiens_hsa049310.64040369
73Prolactin signaling pathway_Homo sapiens_hsa049170.63943223
74Adherens junction_Homo sapiens_hsa045200.62752488
75Proteoglycans in cancer_Homo sapiens_hsa052050.62714203
76HTLV-I infection_Homo sapiens_hsa051660.59459521
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58243261
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57876033
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53967062
80Autoimmune thyroid disease_Homo sapiens_hsa053200.51814269
81VEGF signaling pathway_Homo sapiens_hsa043700.50915359
82Prion diseases_Homo sapiens_hsa050200.45180154
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44361945
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43952689
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.41698856
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40427422
87Bladder cancer_Homo sapiens_hsa052190.39018929
88FoxO signaling pathway_Homo sapiens_hsa040680.38794833
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.37784453
90Focal adhesion_Homo sapiens_hsa045100.37662873
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37146067
92Collecting duct acid secretion_Homo sapiens_hsa049660.36477501
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36418339
94ECM-receptor interaction_Homo sapiens_hsa045120.35869105
95GnRH signaling pathway_Homo sapiens_hsa049120.35105131
96Galactose metabolism_Homo sapiens_hsa000520.34063955
97Mineral absorption_Homo sapiens_hsa049780.33511848
98Sphingolipid metabolism_Homo sapiens_hsa006000.32898873
99Prostate cancer_Homo sapiens_hsa052150.32590938
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31044490
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30398188
102mTOR signaling pathway_Homo sapiens_hsa041500.29168640
103Dorso-ventral axis formation_Homo sapiens_hsa043200.25097301
104Fructose and mannose metabolism_Homo sapiens_hsa000510.24594485
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.23985485
106Pathways in cancer_Homo sapiens_hsa052000.23883827
107Type II diabetes mellitus_Homo sapiens_hsa049300.23316195
108Non-small cell lung cancer_Homo sapiens_hsa052230.21135851
109Endocytosis_Homo sapiens_hsa041440.20428640
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20010132
111ABC transporters_Homo sapiens_hsa020100.19401126
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19264645
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18099416
114Renal cell carcinoma_Homo sapiens_hsa052110.17528633
115Lysine degradation_Homo sapiens_hsa003100.16754005
116Systemic lupus erythematosus_Homo sapiens_hsa053220.15709158
117MAPK signaling pathway_Homo sapiens_hsa040100.14549985

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »