RHBDD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the rhomboid family of membrane-bound proteases and is overexpressed in some breast cancers. Members of this family are involved in intramembrane proteolysis. In mouse, the orthologous protein associates with the Golgi body. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.75148556
2neuron cell-cell adhesion (GO:0007158)4.73780723
3daunorubicin metabolic process (GO:0044597)4.48684640
4polyketide metabolic process (GO:0030638)4.48684640
5doxorubicin metabolic process (GO:0044598)4.48684640
6sodium ion export (GO:0071436)4.46291510
7cellular potassium ion homeostasis (GO:0030007)4.40582780
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.40400223
9synaptic vesicle exocytosis (GO:0016079)4.38079540
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.30550320
11vocalization behavior (GO:0071625)4.24314268
12protein localization to synapse (GO:0035418)4.16280208
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.15618881
14response to pheromone (GO:0019236)4.13131343
15regulation of glutamate receptor signaling pathway (GO:1900449)4.03474827
16regulation of synaptic vesicle exocytosis (GO:2000300)3.94483933
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88659623
18synaptic vesicle maturation (GO:0016188)3.87831658
19locomotory exploration behavior (GO:0035641)3.82111093
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.78345181
21positive regulation of synaptic transmission, GABAergic (GO:0032230)3.75279583
22positive regulation of membrane potential (GO:0045838)3.67059541
23regulation of synaptic vesicle transport (GO:1902803)3.66554392
24glutamate secretion (GO:0014047)3.64335697
25neurotransmitter-gated ion channel clustering (GO:0072578)3.62243307
26postsynaptic membrane organization (GO:0001941)3.60547844
27dendritic spine organization (GO:0097061)3.55894582
28neurotransmitter secretion (GO:0007269)3.55684571
29regulation of neuronal synaptic plasticity (GO:0048168)3.50859049
30detection of calcium ion (GO:0005513)3.49519805
31righting reflex (GO:0060013)3.49327938
32synaptic transmission, glutamatergic (GO:0035249)3.48958551
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.45379198
34neuronal action potential propagation (GO:0019227)3.44163599
35glutamate receptor signaling pathway (GO:0007215)3.43573321
36neuron recognition (GO:0008038)3.39765648
37striatum development (GO:0021756)3.39649002
38positive regulation of neurotransmitter secretion (GO:0001956)3.31821939
39cerebellar granule cell differentiation (GO:0021707)3.31324259
40neuron-neuron synaptic transmission (GO:0007270)3.31282427
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30365798
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28841671
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26993733
44layer formation in cerebral cortex (GO:0021819)3.24965512
45neurotransmitter transport (GO:0006836)3.21883473
46ATP hydrolysis coupled proton transport (GO:0015991)3.21875328
47energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.21875328
48establishment of mitochondrion localization (GO:0051654)3.20130631
49aminoglycoside antibiotic metabolic process (GO:0030647)3.19665973
50dendritic spine morphogenesis (GO:0060997)3.19157358
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18971467
52presynaptic membrane assembly (GO:0097105)3.16888372
53activation of protein kinase A activity (GO:0034199)3.16404365
54exploration behavior (GO:0035640)3.16172256
55cerebellar Purkinje cell layer development (GO:0021680)3.14488901
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12838504
57pyrimidine nucleobase catabolic process (GO:0006208)3.11796687
58chaperone-mediated protein transport (GO:0072321)3.10722229
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09097481
60catecholamine transport (GO:0051937)3.08913298
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08203606
62transferrin transport (GO:0033572)3.06306260
63regulation of voltage-gated calcium channel activity (GO:1901385)3.06175491
64protein localization to cilium (GO:0061512)3.05988743
65regulation of synapse structural plasticity (GO:0051823)3.05838024
66amino acid import (GO:0043090)3.05691631
67potassium ion homeostasis (GO:0055075)3.04260807
68synaptic vesicle transport (GO:0048489)3.03533436
69establishment of synaptic vesicle localization (GO:0097480)3.03533436
70neuromuscular process controlling posture (GO:0050884)3.01439998
71positive regulation of synapse maturation (GO:0090129)3.00168546
72transmission of nerve impulse (GO:0019226)2.99754045
73axonal fasciculation (GO:0007413)2.99224959
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98824198
75regulation of vesicle fusion (GO:0031338)2.97091201
76membrane hyperpolarization (GO:0060081)2.94293857
77response to histamine (GO:0034776)2.94130463
78auditory behavior (GO:0031223)2.93929475
79dopamine transport (GO:0015872)2.93381207
80nonmotile primary cilium assembly (GO:0035058)2.91582878
81neuronal ion channel clustering (GO:0045161)2.91351499
82negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91001877
83acidic amino acid transport (GO:0015800)2.90744169
84L-amino acid import (GO:0043092)2.89376668
85presynaptic membrane organization (GO:0097090)2.88816725
86regulation of neurotransmitter levels (GO:0001505)2.88530185
87gamma-aminobutyric acid transport (GO:0015812)2.88003980
88regulation of postsynaptic membrane potential (GO:0060078)2.87863289
89startle response (GO:0001964)2.87812115
90regulation of excitatory postsynaptic membrane potential (GO:0060079)2.87336807
91regulation of catecholamine metabolic process (GO:0042069)2.86957759
92regulation of dopamine metabolic process (GO:0042053)2.86957759
93long-term memory (GO:0007616)2.86501183
94cell communication by electrical coupling (GO:0010644)2.85043794
95positive regulation of synapse assembly (GO:0051965)2.84763564
96regulation of protein kinase A signaling (GO:0010738)2.84219229
97long-term synaptic potentiation (GO:0060291)2.84159412
98trivalent inorganic cation transport (GO:0072512)2.83700601
99ferric iron transport (GO:0015682)2.83700601
100response to auditory stimulus (GO:0010996)2.83448470
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81449068
102innervation (GO:0060384)2.80862291
103synaptic vesicle endocytosis (GO:0048488)2.80649838
104regulation of synaptic transmission, glutamatergic (GO:0051966)2.80074166
105positive regulation of amino acid transport (GO:0051957)2.79965041
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79510281
107regulation of synaptic transmission, GABAergic (GO:0032228)2.78577767
108G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77570684
109female mating behavior (GO:0060180)2.76571419
110adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.76514926
111mechanosensory behavior (GO:0007638)2.75590124
112proline transport (GO:0015824)2.75274839
113regulation of glutamate secretion (GO:0014048)2.75231490
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75041578
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74610193
116synapse assembly (GO:0007416)2.74581272
117cellular sodium ion homeostasis (GO:0006883)2.74323435
118regulation of synaptic transmission (GO:0050804)2.73625541
119calcium ion-dependent exocytosis (GO:0017156)2.73331892
120positive regulation of neurotransmitter transport (GO:0051590)2.73327778
121regulation of dendritic spine morphogenesis (GO:0061001)2.72722665
122signal release (GO:0023061)2.72488023
123dicarboxylic acid transport (GO:0006835)2.72144468
124regulation of synaptic plasticity (GO:0048167)2.70595129
125nucleobase catabolic process (GO:0046113)2.70511480
126response to dietary excess (GO:0002021)2.69842352
127positive regulation of action potential (GO:0045760)2.69299797
128regulation of neurotransmitter secretion (GO:0046928)2.68895046
129dendrite development (GO:0016358)2.68389951
130cAMP-mediated signaling (GO:0019933)2.67164885
131regulation of neurotransmitter transport (GO:0051588)2.65694715
132regulation of female receptivity (GO:0045924)2.64061771
133long term synaptic depression (GO:0060292)2.63978217
134acid secretion (GO:0046717)2.63933812
135gamma-aminobutyric acid signaling pathway (GO:0007214)2.63521841
136regulation of ARF protein signal transduction (GO:0032012)2.63053972
137cell migration in hindbrain (GO:0021535)2.62998615
138regulation of calcium ion-dependent exocytosis (GO:0017158)2.62829621
139establishment of vesicle localization (GO:0051650)2.61114209
140positive regulation of dendritic spine development (GO:0060999)2.60965559
141vesicle docking involved in exocytosis (GO:0006904)2.59761945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.62324417
2GBX2_23144817_ChIP-Seq_PC3_Human3.96483883
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.98861378
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.91111919
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90767966
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90320462
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82938522
8REST_21632747_ChIP-Seq_MESCs_Mouse2.79174452
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75174417
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.57048011
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51781192
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44376055
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39402630
14TAF15_26573619_Chip-Seq_HEK293_Human2.37039059
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34938645
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34938645
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.34802411
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.34001922
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33093107
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31776676
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28953833
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22618957
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.19406448
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16989969
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13869739
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09351328
27* DNAJC2_21179169_ChIP-ChIP_NT2_Human2.05817714
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97390205
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.95989857
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.93360831
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90423143
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81057889
33LXR_22292898_ChIP-Seq_THP-1_Human1.77659142
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76961274
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.76786645
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76771129
37DROSHA_22980978_ChIP-Seq_HELA_Human1.76433310
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.76029439
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75482676
40P300_19829295_ChIP-Seq_ESCs_Human1.67179078
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62551419
42TET1_21490601_ChIP-Seq_MESCs_Mouse1.58134703
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.58012576
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57621616
45CTCF_27219007_Chip-Seq_Bcells_Human1.54646601
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52455805
47RNF2_27304074_Chip-Seq_NSC_Mouse1.52431220
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51654408
49IGF1R_20145208_ChIP-Seq_DFB_Human1.49643766
50SMAD4_21799915_ChIP-Seq_A2780_Human1.48772344
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47895270
52AR_21572438_ChIP-Seq_LNCaP_Human1.47081549
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42811792
54KDM2B_26808549_Chip-Seq_K562_Human1.41009581
55* SMC4_20622854_ChIP-Seq_HELA_Human1.36940168
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36842700
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35836970
58ZNF274_21170338_ChIP-Seq_K562_Hela1.35533809
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33764651
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30133012
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27262569
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26441474
63* P68_20966046_ChIP-Seq_HELA_Human1.25339130
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24923995
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.24042902
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.23894589
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23682689
68CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.23021426
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22429416
70AR_25329375_ChIP-Seq_VCAP_Human1.19937431
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18159634
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17484278
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15943749
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.15897432
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15822670
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15693972
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15195735
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.15014374
79CTCF_20526341_ChIP-Seq_ESCs_Human1.14614440
80* ELF1_20517297_ChIP-Seq_JURKAT_Human1.12299843
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.12080037
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.11933209
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.11692940
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11377522
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10712259
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09897051
87* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08482171
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08110306
89FUS_26573619_Chip-Seq_HEK293_Human1.07602743
90VDR_22108803_ChIP-Seq_LS180_Human1.07348713
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06765730
92ER_23166858_ChIP-Seq_MCF-7_Human1.06654147
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06134193
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05981842
95OCT4_19829295_ChIP-Seq_ESCs_Human1.04907076
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03881123
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.03708777
98SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03618382
99STAT3_23295773_ChIP-Seq_U87_Human1.03102607
100* CREB1_26743006_Chip-Seq_LNCaP_Human1.02165914
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01057752
102RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00835278
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99167388
104HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97322891
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96672549
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96639123
107SA1_27219007_Chip-Seq_ERYTHROID_Human0.96570135
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95886991
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95441297
110BCL6_27268052_Chip-Seq_Bcells_Human0.95282884
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94278632
112RUNX2_22187159_ChIP-Seq_PCA_Human0.94258108
113NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92790670
114* TCF4_23295773_ChIP-Seq_U87_Human0.92253378
115* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91413466
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90646744
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90384043
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90129837
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90129837
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89024794
121* SA1_27219007_Chip-Seq_Bcells_Human0.87609427
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87219474
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87198705
124* BCOR_27268052_Chip-Seq_Bcells_Human0.87013647
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86915112
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85445317
127JUN_21703547_ChIP-Seq_K562_Human0.85274642
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85050003
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84833534
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.84048953
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83870181
132P53_22387025_ChIP-Seq_ESCs_Mouse0.83773623
133* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83188882
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82930750
135AR_19668381_ChIP-Seq_PC3_Human0.82735150
136EWS_26573619_Chip-Seq_HEK293_Human0.82643321
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82146032
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81131025
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79915927
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.79880813
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79835578
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.79760512
143BCAT_22108803_ChIP-Seq_LS180_Human0.79067037
144RARB_24833708_ChIP-Seq_LIVER_Mouse0.78535571
145RACK7_27058665_Chip-Seq_MCF-7_Human0.77233070
146* PHF8_20622854_ChIP-Seq_HELA_Human0.77083190
147TP53_20018659_ChIP-ChIP_R1E_Mouse0.77002097
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.76237826
149SOX3_22085726_ChIP-Seq_NPCs_Mouse0.75927808
150REST_19997604_ChIP-ChIP_NEURONS_Mouse0.75054286
151KLF4_19829295_ChIP-Seq_ESCs_Human0.73160372
152CTCF_18555785_ChIP-Seq_MESCs_Mouse0.72721846
153SMAD4_21741376_ChIP-Seq_ESCs_Human0.72663922
154CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71729390
155TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.71557561
156YY1_21170310_ChIP-Seq_MESCs_Mouse0.71472180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.16181790
2MP0004859_abnormal_synaptic_plasticity3.88896009
3MP0005645_abnormal_hypothalamus_physiol3.70107848
4MP0003635_abnormal_synaptic_transmissio3.13363851
5MP0001984_abnormal_olfaction2.94974487
6MP0009745_abnormal_behavioral_response2.69894713
7MP0001529_abnormal_vocalization2.69709643
8MP0005646_abnormal_pituitary_gland2.68612735
9MP0001968_abnormal_touch/_nociception2.63183983
10MP0002064_seizures2.56960455
11MP0005423_abnormal_somatic_nervous2.55942007
12MP0003122_maternal_imprinting2.51262396
13MP0006276_abnormal_autonomic_nervous2.49706989
14MP0002063_abnormal_learning/memory/cond2.45408620
15MP0002572_abnormal_emotion/affect_behav2.41377019
16MP0002272_abnormal_nervous_system2.35542721
17MP0009046_muscle_twitch2.27699264
18MP0004270_analgesia2.24914072
19MP0002736_abnormal_nociception_after2.20328414
20MP0001486_abnormal_startle_reflex2.18580791
21MP0002734_abnormal_mechanical_nocicepti2.14057506
22MP0002653_abnormal_ependyma_morphology2.11986481
23MP0001188_hyperpigmentation1.96686805
24MP0002735_abnormal_chemical_nociception1.94472321
25MP0004142_abnormal_muscle_tone1.86132458
26MP0002822_catalepsy1.84075220
27MP0002557_abnormal_social/conspecific_i1.82331447
28MP0005394_taste/olfaction_phenotype1.81375673
29MP0005499_abnormal_olfactory_system1.81375673
30MP0001501_abnormal_sleep_pattern1.81161426
31MP0001440_abnormal_grooming_behavior1.78765560
32MP0002067_abnormal_sensory_capabilities1.78087311
33MP0005551_abnormal_eye_electrophysiolog1.77799168
34MP0006292_abnormal_olfactory_placode1.77216579
35MP0002733_abnormal_thermal_nociception1.75429414
36MP0001970_abnormal_pain_threshold1.73457276
37MP0001502_abnormal_circadian_rhythm1.73292856
38MP0002184_abnormal_innervation1.71515869
39MP0000013_abnormal_adipose_tissue1.70723148
40MP0005409_darkened_coat_color1.70324969
41MP0010386_abnormal_urinary_bladder1.68744150
42MP0006072_abnormal_retinal_apoptosis1.65336445
43MP0002909_abnormal_adrenal_gland1.61877060
44MP0001905_abnormal_dopamine_level1.60208915
45MP0000778_abnormal_nervous_system1.51314998
46MP0003123_paternal_imprinting1.50357779
47MP0005386_behavior/neurological_phenoty1.47788505
48MP0004924_abnormal_behavior1.47788505
49MP0003183_abnormal_peptide_metabolism1.47549796
50MP0008789_abnormal_olfactory_epithelium1.45976390
51MP0002876_abnormal_thyroid_physiology1.43571565
52MP0003879_abnormal_hair_cell1.41114915
53MP0002638_abnormal_pupillary_reflex1.40445119
54MP0004043_abnormal_pH_regulation1.40313489
55MP0000631_abnormal_neuroendocrine_gland1.36894715
56MP0008569_lethality_at_weaning1.36795833
57MP0002882_abnormal_neuron_morphology1.29416238
58MP0000920_abnormal_myelination1.24624347
59MP0004811_abnormal_neuron_physiology1.24200592
60MP0000955_abnormal_spinal_cord1.23013641
61MP0005253_abnormal_eye_physiology1.22581204
62MP0000604_amyloidosis1.20004193
63MP0005379_endocrine/exocrine_gland_phen1.18304479
64MP0003690_abnormal_glial_cell1.17098987
65MP0002066_abnormal_motor_capabilities/c1.14608903
66MP0002229_neurodegeneration1.10445961
67MP0008875_abnormal_xenobiotic_pharmacok1.09893472
68MP0003075_altered_response_to1.08434753
69MP0004885_abnormal_endolymph1.08108216
70MP0008260_abnormal_autophagy1.04803678
71MP0009780_abnormal_chondrocyte_physiolo1.00517870
72MP0003787_abnormal_imprinting0.99531062
73MP0004742_abnormal_vestibular_system0.99372501
74MP0002752_abnormal_somatic_nervous0.99348490
75MP0002069_abnormal_eating/drinking_beha0.99176844
76MP0001664_abnormal_digestion0.99008780
77MP0000566_synostosis0.95762535
78MP0008872_abnormal_physiological_respon0.93718680
79MP0005058_abnormal_lysosome_morphology0.93161850
80MP0000639_abnormal_adrenal_gland0.91050106
81MP0003172_abnormal_lysosome_physiology0.90935691
82MP0002152_abnormal_brain_morphology0.90834266
83MP0003121_genomic_imprinting0.90362319
84MP0004858_abnormal_nervous_system0.90095185
85MP0008961_abnormal_basal_metabolism0.89934804
86MP0001986_abnormal_taste_sensitivity0.89835327
87MP0002090_abnormal_vision0.89705780
88MP0001963_abnormal_hearing_physiology0.89632356
89MP0003633_abnormal_nervous_system0.89068273
90MP0003283_abnormal_digestive_organ0.87804946
91MP0005535_abnormal_body_temperature0.86862973
92MP0003329_amyloid_beta_deposits0.84429254
93MP0000026_abnormal_inner_ear0.82818846
94MP0008874_decreased_physiological_sensi0.78988647
95MP0002837_dystrophic_cardiac_calcinosis0.75971895
96MP0000678_abnormal_parathyroid_gland0.75738274
97MP0004145_abnormal_muscle_electrophysio0.75083528
98MP0005167_abnormal_blood-brain_barrier0.74593259
99MP0004133_heterotaxia0.73981914
100MP0003632_abnormal_nervous_system0.71339559
101MP0004085_abnormal_heartbeat0.69576555
102MP0001177_atelectasis0.69384989
103MP0002751_abnormal_autonomic_nervous0.68318043
104MP0003631_nervous_system_phenotype0.65911725
105MP0006035_abnormal_mitochondrial_morpho0.65726148
106MP0001944_abnormal_pancreas_morphology0.64018599
107MP0002938_white_spotting0.63602883
108MP0003634_abnormal_glial_cell0.62784345
109MP0002693_abnormal_pancreas_physiology0.62226617
110MP0009840_abnormal_foam_cell0.62093559
111MP0000681_abnormal_thyroid_gland0.61366023
112MP0005195_abnormal_posterior_eye0.61068114
113MP0000751_myopathy0.60179284
114MP0003011_delayed_dark_adaptation0.59919589
115MP0004147_increased_porphyrin_level0.59451339
116MP0004019_abnormal_vitamin_homeostasis0.59421638
117MP0009379_abnormal_foot_pigmentation0.58073988
118MP0003137_abnormal_impulse_conducting0.57763140
119MP0002163_abnormal_gland_morphology0.57074001
120MP0001346_abnormal_lacrimal_gland0.56853196
121MP0010329_abnormal_lipoprotein_level0.52437536
122MP0003956_abnormal_body_size0.49461901
123MP0005623_abnormal_meninges_morphology0.48639617
124MP0001348_abnormal_lacrimal_gland0.48480801

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.13614361
2Visual hallucinations (HP:0002367)4.06972511
3Action tremor (HP:0002345)3.88166634
4Febrile seizures (HP:0002373)3.79883311
5Hypothermia (HP:0002045)3.78000508
6Myokymia (HP:0002411)3.69222499
7Focal seizures (HP:0007359)3.56302038
8Epileptic encephalopathy (HP:0200134)3.54778563
9Neurofibrillary tangles (HP:0002185)3.37191954
10Atonic seizures (HP:0010819)3.32879690
11Gait imbalance (HP:0002141)3.32571377
12Medial flaring of the eyebrow (HP:0010747)3.25538910
13Diplopia (HP:0000651)3.23022056
14Abnormality of binocular vision (HP:0011514)3.23022056
15Mutism (HP:0002300)3.19564795
16Congenital primary aphakia (HP:0007707)3.10680418
17Retinal dysplasia (HP:0007973)3.06771877
18Nephrogenic diabetes insipidus (HP:0009806)3.05950810
19Hand muscle atrophy (HP:0009130)3.05918598
20Absence seizures (HP:0002121)3.05665093
21Neuronal loss in central nervous system (HP:0002529)3.03947665
22Anxiety (HP:0000739)2.97239018
23Type II lissencephaly (HP:0007260)2.96786223
24Spastic gait (HP:0002064)2.96701418
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96155583
26Pheochromocytoma (HP:0002666)2.89386003
27Delusions (HP:0000746)2.85621443
28Generalized tonic-clonic seizures (HP:0002069)2.85038746
29Neuroendocrine neoplasm (HP:0100634)2.83343947
30Mitochondrial inheritance (HP:0001427)2.82473519
31Acute necrotizing encephalopathy (HP:0006965)2.82433983
32Hypsarrhythmia (HP:0002521)2.79486907
33Severe visual impairment (HP:0001141)2.77467677
34Abnormal mitochondria in muscle tissue (HP:0008316)2.76818853
35Polyphagia (HP:0002591)2.74081433
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.72697911
37Hepatocellular necrosis (HP:0001404)2.71615375
38Decreased circulating renin level (HP:0003351)2.69922460
39Limb dystonia (HP:0002451)2.69887156
40Abnormality of midbrain morphology (HP:0002418)2.69608156
41Molar tooth sign on MRI (HP:0002419)2.69608156
42Dialeptic seizures (HP:0011146)2.69501567
43Peripheral hypomyelination (HP:0007182)2.68728311
44Abnormal hair whorl (HP:0010721)2.66090019
45Intention tremor (HP:0002080)2.61606538
46Agitation (HP:0000713)2.60764073
47Abnormal ciliary motility (HP:0012262)2.60140385
48Akinesia (HP:0002304)2.56928097
49Cerebral inclusion bodies (HP:0100314)2.55361861
50Growth hormone excess (HP:0000845)2.54713836
51Cerebral hypomyelination (HP:0006808)2.54125060
52Progressive cerebellar ataxia (HP:0002073)2.52523949
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.52458822
54Absent/shortened dynein arms (HP:0200106)2.52458822
55Hemiparesis (HP:0001269)2.52003074
56Abnormal eating behavior (HP:0100738)2.51783939
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50819317
58Abnormal respiratory epithelium morphology (HP:0012253)2.50556316
59Abnormal respiratory motile cilium morphology (HP:0005938)2.50556316
60Distal upper limb amyotrophy (HP:0007149)2.49162627
61Upper limb amyotrophy (HP:0009129)2.49162627
62Tetraplegia (HP:0002445)2.48321045
63Abnormal rod and cone electroretinograms (HP:0008323)2.47138040
64Abnormality of calcium-phosphate metabolism (HP:0100530)2.46168641
65Cholecystitis (HP:0001082)2.44134759
66Abnormal gallbladder physiology (HP:0012438)2.44134759
67Truncal ataxia (HP:0002078)2.43586552
68Papilledema (HP:0001085)2.41134902
69Ankle clonus (HP:0011448)2.37792436
70Progressive macrocephaly (HP:0004481)2.36307371
71Pancreatic fibrosis (HP:0100732)2.33807106
72Increased CSF lactate (HP:0002490)2.31446751
73Split foot (HP:0001839)2.31394522
74Supranuclear gaze palsy (HP:0000605)2.30855677
75True hermaphroditism (HP:0010459)2.30609395
76Apathy (HP:0000741)2.30338631
77Status epilepticus (HP:0002133)2.30312786
78Dysmetria (HP:0001310)2.29554963
79Impaired vibration sensation in the lower limbs (HP:0002166)2.28919197
80Vaginal atresia (HP:0000148)2.27835759
81Poor suck (HP:0002033)2.26403000
82Increased hepatocellular lipid droplets (HP:0006565)2.25688359
83Genital tract atresia (HP:0001827)2.25635164
84Acute encephalopathy (HP:0006846)2.25475665
85Menstrual irregularities (HP:0000858)2.24666143
86Absent speech (HP:0001344)2.23221529
87Diminished motivation (HP:0000745)2.20817575
88Hepatic necrosis (HP:0002605)2.20658863
89Optic disc pallor (HP:0000543)2.20346123
90Rhinitis (HP:0012384)2.19832967
91Lissencephaly (HP:0001339)2.18153291
92Depression (HP:0000716)2.18089211
93Failure to thrive in infancy (HP:0001531)2.16878877
94Obstructive sleep apnea (HP:0002870)2.16635623
95Postural instability (HP:0002172)2.15009620
96Hyperaldosteronism (HP:0000859)2.10136890
97Abnormal respiratory motile cilium physiology (HP:0012261)2.09814191
98Hyperventilation (HP:0002883)2.09671189
99Poor coordination (HP:0002370)2.08548348
100Microvesicular hepatic steatosis (HP:0001414)2.07221827
101Aplasia/Hypoplasia of the lens (HP:0008063)2.06948052
102Decreased central vision (HP:0007663)2.06350247
103Specific learning disability (HP:0001328)2.05684985
104Hyperactive renin-angiotensin system (HP:0000841)2.05684784
105Muscular hypotonia of the trunk (HP:0008936)2.05044750
106Central scotoma (HP:0000603)2.04799849
107Retinal atrophy (HP:0001105)2.04570920
108Upper limb muscle weakness (HP:0003484)2.04092774
109Renal Fanconi syndrome (HP:0001994)2.02501266
110Abnormality of the lower motor neuron (HP:0002366)2.01301531
111Hypokinesia (HP:0002375)1.99543542
112Hypokalemic alkalosis (HP:0001949)1.99514005
113Ulnar claw (HP:0001178)1.99119670
114Rigidity (HP:0002063)1.99033012
115Lipid accumulation in hepatocytes (HP:0006561)1.98363537
116Esotropia (HP:0000565)1.98057970
117Poor eye contact (HP:0000817)1.97988681
118Nephronophthisis (HP:0000090)1.97757695
119Urinary urgency (HP:0000012)1.95457672
120Abnormality of the corticospinal tract (HP:0002492)1.93952670
121Anosmia (HP:0000458)1.93485083
122Annular pancreas (HP:0001734)1.93435950
123Congenital stationary night blindness (HP:0007642)1.92375415
124Broad-based gait (HP:0002136)1.91468090
125Focal dystonia (HP:0004373)1.91245441
126CNS hypomyelination (HP:0003429)1.90810016
127Epileptiform EEG discharges (HP:0011182)1.90629213
128Bony spicule pigmentary retinopathy (HP:0007737)1.90303294
129Progressive inability to walk (HP:0002505)1.89706343
130Abnormality of renin-angiotensin system (HP:0000847)1.89490855
131Pancreatic cysts (HP:0001737)1.88596751
132Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88473338
133Abnormality of macular pigmentation (HP:0008002)1.88008321
134Attenuation of retinal blood vessels (HP:0007843)1.86040369
135EEG with generalized epileptiform discharges (HP:0011198)1.85582611
136Occipital encephalocele (HP:0002085)1.85385605
137Diminished movement (HP:0002374)1.85001819
138Clonus (HP:0002169)1.84160496
139Amyotrophic lateral sclerosis (HP:0007354)1.82591907
140Chronic bronchitis (HP:0004469)1.81913518
141Heterochromia iridis (HP:0001100)1.80929443
142Spastic tetraplegia (HP:0002510)1.80270056
143Sleep apnea (HP:0010535)1.79331300
144Bradykinesia (HP:0002067)1.78804982
145Lower limb muscle weakness (HP:0007340)1.78726598
146Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78700586
147Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78700586
148Amblyopia (HP:0000646)1.77797161
149Abnormal EKG (HP:0003115)1.77554708
150Craniofacial dystonia (HP:0012179)1.77029876
151Blue irides (HP:0000635)1.76677866
152Torticollis (HP:0000473)1.75998805
153Urinary bladder sphincter dysfunction (HP:0002839)1.75739389
154Psychosis (HP:0000709)1.73448736
155Fetal akinesia sequence (HP:0001989)1.72444820
156Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71843295
157Abnormality of polysaccharide metabolism (HP:0011012)1.71843295
158Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71843295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.85485520
2CASK3.66129411
3NTRK33.57050112
4MAP3K123.43905757
5TESK13.03822232
6MAP2K72.92890152
7SIK32.61513156
8MINK12.59719002
9MAP3K92.58072300
10MARK12.41086282
11NTRK22.34755164
12EPHA42.31799467
13LIMK12.06171100
14MAP3K42.04883640
15PNCK1.90580933
16ARAF1.88400867
17MAPK131.85616201
18MAP2K41.78479305
19WNK31.66770156
20CDK191.62112119
21MUSK1.59391589
22MAP3K111.57668897
23CAMK11.47585801
24IRAK21.43867060
25MAP4K21.42380568
26UHMK11.41035248
27PRPF4B1.33600051
28CAMKK21.27546690
29SGK2231.23956159
30SGK4941.23956159
31KSR11.22134641
32TIE11.22107785
33MAPK151.21659107
34AKT31.19423531
35TNK21.18510030
36SIK21.17889360
37SGK21.17105281
38CDK51.16825484
39BRAF1.16706376
40LMTK21.12815870
41FES1.10196881
42PRKCG1.09979081
43DAPK21.08974084
44DYRK21.06190495
45NTRK11.00999846
46PIK3CG1.00328009
47TESK20.98984391
48GRK50.98884321
49PRKD30.98188943
50CAMK2A0.97210856
51CDK150.96972599
52CAMK1G0.96508136
53DAPK10.96247808
54CSNK1G20.94303868
55STK160.92369530
56CDK11A0.90811190
57IRAK10.88604134
58INSRR0.86199866
59PIM20.86185693
60PHKG20.85501538
61PHKG10.85501538
62ADRBK20.85112966
63OXSR10.85039938
64RIPK40.84956108
65CSNK1G30.84265875
66GRK70.83284887
67CAMK2B0.83031392
68EPHA30.83021794
69EPHB10.82230700
70TRIM280.80782141
71MAP3K130.80510216
72RIPK10.77893612
73EPHA20.77282204
74BMPR20.77074926
75BMPR1B0.77028507
76CAMKK10.75833557
77PLK20.75053097
78NME10.74124296
79BCR0.72556254
80PRKCH0.71576777
81MAP3K10.70864753
82DYRK1A0.70001481
83PRKCZ0.68283070
84TAOK20.67705972
85PASK0.67255596
86CDK80.66605227
87CAMK2D0.64768146
88ADRBK10.63961693
89PINK10.59469857
90HIPK20.58887246
91PKN10.58821322
92MAPKAPK30.58223420
93KSR20.57617828
94CAMK2G0.57349349
95CSNK1A1L0.56584632
96PAK30.56474877
97TYRO30.55455198
98MAP2K60.54968290
99SIK10.53959133
100CCNB10.53643390
101MAP3K60.52718374
102MARK20.51609525
103DAPK30.51596331
104ROCK20.50065182
105BRSK10.48973062
106PDK10.48659439
107MYLK0.46575785
108SGK30.46060313
109PDPK10.45878443
110LATS20.45249001
111CDK180.44714690
112TAOK10.44087711
113FGFR20.43244530
114PRKACA0.43223793
115TSSK60.43145187
116STK380.42815859
117PRKCE0.42598854
118MAPK120.42487607
119NEK60.41813894
120MAPKAPK50.41622323
121PAK60.41172774
122RPS6KA20.40540876
123YES10.40431854
124CDK140.39165854
125TAOK30.39054311
126WNK40.38930013
127CSNK1A10.38850331
128CSNK1G10.38663900
129DYRK1B0.38465839
130FYN0.38364901
131STK110.38328060
132PRKCA0.37877198
133PRKD20.36820645
134BCKDK0.36724456
135CAMK40.36654377
136SGK10.36364229
137ERBB20.36159846
138MAPK100.36104341

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97750089
2Synaptic vesicle cycle_Homo sapiens_hsa047213.45981106
3Olfactory transduction_Homo sapiens_hsa047402.99912769
4GABAergic synapse_Homo sapiens_hsa047272.85566777
5Oxidative phosphorylation_Homo sapiens_hsa001902.81548179
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66031303
7Morphine addiction_Homo sapiens_hsa050322.54489900
8Phototransduction_Homo sapiens_hsa047442.49546713
9Circadian entrainment_Homo sapiens_hsa047132.48895743
10Parkinsons disease_Homo sapiens_hsa050122.36796961
11Taste transduction_Homo sapiens_hsa047422.36497909
12Insulin secretion_Homo sapiens_hsa049112.34342502
13Collecting duct acid secretion_Homo sapiens_hsa049662.24609736
14Glutamatergic synapse_Homo sapiens_hsa047242.19603117
15Amphetamine addiction_Homo sapiens_hsa050312.13724464
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.92550696
17Serotonergic synapse_Homo sapiens_hsa047261.91325051
18Alzheimers disease_Homo sapiens_hsa050101.89298281
19Cocaine addiction_Homo sapiens_hsa050301.83784076
20Dopaminergic synapse_Homo sapiens_hsa047281.82395484
21Vitamin B6 metabolism_Homo sapiens_hsa007501.77064618
22Long-term potentiation_Homo sapiens_hsa047201.75828709
23Cardiac muscle contraction_Homo sapiens_hsa042601.73569064
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73510483
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67959872
26Salivary secretion_Homo sapiens_hsa049701.67956582
27Huntingtons disease_Homo sapiens_hsa050161.64091167
28Cholinergic synapse_Homo sapiens_hsa047251.62007182
29Protein export_Homo sapiens_hsa030601.61957685
30Vibrio cholerae infection_Homo sapiens_hsa051101.61559672
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.56646143
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56320072
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51565610
34Gastric acid secretion_Homo sapiens_hsa049711.49506791
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45562213
36Renin secretion_Homo sapiens_hsa049241.43786501
37Calcium signaling pathway_Homo sapiens_hsa040201.41739290
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36136829
39Long-term depression_Homo sapiens_hsa047301.35020560
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25320991
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16013896
42Oxytocin signaling pathway_Homo sapiens_hsa049211.12825193
43Fatty acid elongation_Homo sapiens_hsa000621.10781958
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.09395969
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04061371
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03860043
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99926466
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94798422
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94114230
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93844709
51cAMP signaling pathway_Homo sapiens_hsa040240.93410136
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90823651
53Gap junction_Homo sapiens_hsa045400.89294535
54Butanoate metabolism_Homo sapiens_hsa006500.87823665
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86584104
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84113254
57GnRH signaling pathway_Homo sapiens_hsa049120.82433018
58Melanogenesis_Homo sapiens_hsa049160.81477181
59Lysosome_Homo sapiens_hsa041420.80708268
60Steroid biosynthesis_Homo sapiens_hsa001000.79039121
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78353358
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77663922
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77293796
64Arginine and proline metabolism_Homo sapiens_hsa003300.76872670
65beta-Alanine metabolism_Homo sapiens_hsa004100.76704702
66Circadian rhythm_Homo sapiens_hsa047100.74992153
67N-Glycan biosynthesis_Homo sapiens_hsa005100.74907218
68Type II diabetes mellitus_Homo sapiens_hsa049300.74007859
69Phenylalanine metabolism_Homo sapiens_hsa003600.73408143
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72787251
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72225367
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.67607326
73Thyroid hormone synthesis_Homo sapiens_hsa049180.66727668
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66316295
75Regulation of autophagy_Homo sapiens_hsa041400.65159465
76Endocytosis_Homo sapiens_hsa041440.63441719
77Folate biosynthesis_Homo sapiens_hsa007900.62578912
78Axon guidance_Homo sapiens_hsa043600.62266376
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62100490
80Pancreatic secretion_Homo sapiens_hsa049720.60523677
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.59739111
82Histidine metabolism_Homo sapiens_hsa003400.57001836
83Mineral absorption_Homo sapiens_hsa049780.56695119
84Estrogen signaling pathway_Homo sapiens_hsa049150.54389610
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53130680
86Type I diabetes mellitus_Homo sapiens_hsa049400.52744108
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50841375
88Sulfur relay system_Homo sapiens_hsa041220.50754289
89Arginine biosynthesis_Homo sapiens_hsa002200.50609037
90Alcoholism_Homo sapiens_hsa050340.50135088
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48275818
92Oocyte meiosis_Homo sapiens_hsa041140.47155225
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44924507
94Biosynthesis of amino acids_Homo sapiens_hsa012300.42965601
95Glucagon signaling pathway_Homo sapiens_hsa049220.42959305
96Rheumatoid arthritis_Homo sapiens_hsa053230.42687922
97ErbB signaling pathway_Homo sapiens_hsa040120.40840281
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38645396
99Purine metabolism_Homo sapiens_hsa002300.38568383
100Fatty acid metabolism_Homo sapiens_hsa012120.38296931
101Peroxisome_Homo sapiens_hsa041460.38222544
102Phagosome_Homo sapiens_hsa041450.38147215
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37928114
104Galactose metabolism_Homo sapiens_hsa000520.37205050
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.36938877
106Other glycan degradation_Homo sapiens_hsa005110.35821466
107Ovarian steroidogenesis_Homo sapiens_hsa049130.35801625
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34951852
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33898720
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.33380519
111AMPK signaling pathway_Homo sapiens_hsa041520.32630783
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.31515135
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29296565
114Glioma_Homo sapiens_hsa052140.29141798
115Sphingolipid metabolism_Homo sapiens_hsa006000.28939146
116Dilated cardiomyopathy_Homo sapiens_hsa054140.28050961
117Sulfur metabolism_Homo sapiens_hsa009200.26469956
118Wnt signaling pathway_Homo sapiens_hsa043100.26072701
119Fructose and mannose metabolism_Homo sapiens_hsa000510.24929381
120Metabolic pathways_Homo sapiens_hsa011000.24904787
121Hedgehog signaling pathway_Homo sapiens_hsa043400.24866890
122Pyruvate metabolism_Homo sapiens_hsa006200.24049289
123Insulin signaling pathway_Homo sapiens_hsa049100.20415421
124Bile secretion_Homo sapiens_hsa049760.20090039
125Prion diseases_Homo sapiens_hsa050200.19805898
126Inositol phosphate metabolism_Homo sapiens_hsa005620.17714210
127Ras signaling pathway_Homo sapiens_hsa040140.17617431
128MAPK signaling pathway_Homo sapiens_hsa040100.16671779
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16489353

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