RGS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.76211462
2glutamate secretion (GO:0014047)5.49547245
3regulation of synaptic vesicle exocytosis (GO:2000300)5.20353414
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.13676199
5synaptic vesicle exocytosis (GO:0016079)5.12647150
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.01391618
7protein localization to synapse (GO:0035418)4.92080111
8negative regulation of dendrite morphogenesis (GO:0050774)4.90961998
9neuronal action potential propagation (GO:0019227)4.80636741
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.80559034
11presynaptic membrane assembly (GO:0097105)4.77012108
12neuron cell-cell adhesion (GO:0007158)4.76789352
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.71126565
14vocalization behavior (GO:0071625)4.68274732
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58983430
16presynaptic membrane organization (GO:0097090)4.49491784
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.48828585
18regulation of synaptic vesicle transport (GO:1902803)4.46640984
19regulation of glutamate receptor signaling pathway (GO:1900449)4.43551047
20synaptic vesicle maturation (GO:0016188)4.43168804
21cellular potassium ion homeostasis (GO:0030007)4.42434256
22neurotransmitter-gated ion channel clustering (GO:0072578)4.38729011
23regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.08599974
24positive regulation of neurotransmitter secretion (GO:0001956)4.06597221
25postsynaptic membrane organization (GO:0001941)4.02133862
26locomotory exploration behavior (GO:0035641)3.97176705
27neuron-neuron synaptic transmission (GO:0007270)3.92281035
28negative regulation of dendrite development (GO:2000171)3.86755649
29neurotransmitter secretion (GO:0007269)3.82923392
30synaptic transmission, glutamatergic (GO:0035249)3.74271053
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72705290
32dendritic spine morphogenesis (GO:0060997)3.72652816
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70431822
34neuronal action potential (GO:0019228)3.70358389
35regulation of neurotransmitter secretion (GO:0046928)3.70120344
36potassium ion homeostasis (GO:0055075)3.70030901
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67148070
38positive regulation of neurotransmitter transport (GO:0051590)3.64308219
39membrane depolarization during action potential (GO:0086010)3.62585417
40regulation of synaptic transmission, glutamatergic (GO:0051966)3.59061606
41insulin secretion (GO:0030073)3.58336061
42positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.56808553
43regulation of postsynaptic membrane potential (GO:0060078)3.56756609
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.56431686
45proline transport (GO:0015824)3.52864289
46response to histamine (GO:0034776)3.51948315
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.51518535
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.49452111
49glycerophospholipid catabolic process (GO:0046475)3.49283764
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49005652
51glutamate receptor signaling pathway (GO:0007215)3.47489875
52positive regulation of muscle hypertrophy (GO:0014742)3.44080786
53positive regulation of cardiac muscle hypertrophy (GO:0010613)3.44080786
54long-term synaptic potentiation (GO:0060291)3.44057917
55regulation of neuronal synaptic plasticity (GO:0048168)3.41712555
56urinary tract smooth muscle contraction (GO:0014848)3.41316126
57response to gravity (GO:0009629)3.41157283
58regulation of glutamate secretion (GO:0014048)3.35700430
59detection of temperature stimulus involved in sensory perception (GO:0050961)3.35388825
60detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.35388825
61regulation of Rac protein signal transduction (GO:0035020)3.34588693
62regulation of neurotransmitter transport (GO:0051588)3.34474553
63positive regulation of synapse maturation (GO:0090129)3.33580231
64regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.32451335
65regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.32451335
66regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32289826
67membrane depolarization (GO:0051899)3.30298260
68regulation of synaptic plasticity (GO:0048167)3.29797064
69cerebellar granule cell differentiation (GO:0021707)3.29721842
70behavioral response to cocaine (GO:0048148)3.29486881
71mechanosensory behavior (GO:0007638)3.29254200
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.28962602
73positive regulation of membrane potential (GO:0045838)3.25646453
74activation of protein kinase A activity (GO:0034199)3.25431942
75regulation of voltage-gated calcium channel activity (GO:1901385)3.24304898
76adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.23079936
77regulation of vesicle fusion (GO:0031338)3.21379214
78auditory behavior (GO:0031223)3.21100327
79calcium ion-dependent exocytosis (GO:0017156)3.20623460
80regulation of neurotransmitter uptake (GO:0051580)3.20311849
81neuromuscular process controlling posture (GO:0050884)3.19840795
82suckling behavior (GO:0001967)3.17029390
83regulation of synapse structural plasticity (GO:0051823)3.16115911
84exploration behavior (GO:0035640)3.14589845
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09640559
86neurotransmitter transport (GO:0006836)3.08277090
87negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06924495
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06607653
89cerebellar Purkinje cell differentiation (GO:0021702)3.06322214
90positive regulation of synaptic transmission (GO:0050806)3.03965630
91sodium ion export (GO:0071436)3.02236045
92regulation of ARF protein signal transduction (GO:0032012)2.96323851
93detection of calcium ion (GO:0005513)2.96246758
94negative regulation of cation channel activity (GO:2001258)2.96044596
95detection of temperature stimulus (GO:0016048)2.96014339
96cell migration in hindbrain (GO:0021535)2.95303994
97negative regulation of amino acid transport (GO:0051956)2.94869793
98potassium ion import (GO:0010107)2.94301837
99serotonin metabolic process (GO:0042428)2.94173425
100synaptic transmission (GO:0007268)2.94101674
101inositol phosphate catabolic process (GO:0071545)2.91304601
102signal release (GO:0023061)2.90738196
103regulation of type B pancreatic cell apoptotic process (GO:2000674)2.90564057
104membrane assembly (GO:0071709)2.90253670
105synaptic vesicle endocytosis (GO:0048488)2.90201059
106response to auditory stimulus (GO:0010996)2.87937492
107neuron recognition (GO:0008038)2.87438395
108gamma-aminobutyric acid transport (GO:0015812)2.86114096
109membrane hyperpolarization (GO:0060081)2.85917438
110innervation (GO:0060384)2.85507379
111synapse assembly (GO:0007416)2.85363468
112regulation of dendritic spine morphogenesis (GO:0061001)2.84119708
113regulation of synaptic transmission (GO:0050804)2.83075662
114positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.82899331
115regulation of dendritic spine development (GO:0060998)2.82352725
116fear response (GO:0042596)2.82252914
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81905227
118regulation of neurotransmitter levels (GO:0001505)2.81607792
119ATP hydrolysis coupled proton transport (GO:0015991)2.81466078
120energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.81466078
121regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81429939
122regulation of protein kinase A signaling (GO:0010738)2.79652493
123positive regulation of dendritic spine development (GO:0060999)2.79195519
124layer formation in cerebral cortex (GO:0021819)2.78656094
125transferrin transport (GO:0033572)2.78077424
126peptide hormone processing (GO:0016486)2.77781647
127alanine transport (GO:0032328)2.74118322
128cerebellar Purkinje cell layer development (GO:0021680)2.73887604
129dendritic spine organization (GO:0097061)2.69919936
130regulation of calcium ion-dependent exocytosis (GO:0017158)2.69846916
131vesicle docking involved in exocytosis (GO:0006904)2.69270217
132phosphorylated carbohydrate dephosphorylation (GO:0046838)2.67734821
133inositol phosphate dephosphorylation (GO:0046855)2.67734821
134positive regulation of fibroblast migration (GO:0010763)2.63579041
135positive regulation of vesicle fusion (GO:0031340)2.63276482
136cell communication by electrical coupling (GO:0010644)2.62410028
137cellular potassium ion transport (GO:0071804)2.61465676
138potassium ion transmembrane transport (GO:0071805)2.61465676
139primary amino compound metabolic process (GO:1901160)2.57811039
140regulation of exocytosis (GO:0017157)2.56539737
141vesicle docking (GO:0048278)2.55684855
142positive regulation of amine transport (GO:0051954)2.52974852
143axonal fasciculation (GO:0007413)2.50200567
144regulation of respiratory gaseous exchange (GO:0043576)2.49994606
145negative regulation of hormone biosynthetic process (GO:0032353)2.49718422
146regulation of extracellular matrix disassembly (GO:0010715)2.49151776
147regulation of synaptic transmission, dopaminergic (GO:0032225)2.49014841
148regulation of cell communication by electrical coupling (GO:0010649)2.48767059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.81394329
2GBX2_23144817_ChIP-Seq_PC3_Human4.29311318
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.28217094
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.29929292
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12552219
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98041053
7TAF15_26573619_Chip-Seq_HEK293_Human2.82946240
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70400757
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65945860
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63118741
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63118741
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61809404
13REST_21632747_ChIP-Seq_MESCs_Mouse2.57150900
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.54924720
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51398769
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.50244939
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45648234
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42337464
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.41847601
20* RARB_27405468_Chip-Seq_BRAIN_Mouse2.34522113
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27143811
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25986360
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.13555165
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10278910
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07326902
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.03257953
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.01026968
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94146415
29VDR_22108803_ChIP-Seq_LS180_Human1.92171081
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89543433
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.89373089
32DROSHA_22980978_ChIP-Seq_HELA_Human1.83360110
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82825424
34P300_19829295_ChIP-Seq_ESCs_Human1.80622237
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73693551
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72325100
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67163705
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.66759170
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60954991
40AR_21572438_ChIP-Seq_LNCaP_Human1.59691756
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54647407
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50745600
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.49404915
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49099329
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47272908
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47106728
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46126182
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.45251524
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40998981
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40524827
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39095141
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.37057956
53AR_25329375_ChIP-Seq_VCAP_Human1.36732290
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.36605858
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36091869
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34726380
57STAT3_23295773_ChIP-Seq_U87_Human1.32722173
58AHR_22903824_ChIP-Seq_MCF-7_Human1.28752648
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28219124
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.27850533
61* SMAD_19615063_ChIP-ChIP_OVARY_Human1.27531942
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.27159312
63RNF2_27304074_Chip-Seq_NSC_Mouse1.25815193
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25312680
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25176440
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25032288
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.24287646
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24216927
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23192570
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20752822
71FUS_26573619_Chip-Seq_HEK293_Human1.19353226
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19185333
73TCF4_23295773_ChIP-Seq_U87_Human1.17940610
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16903777
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.16224241
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15158766
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13742948
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13228216
79BCAT_22108803_ChIP-Seq_LS180_Human1.12639125
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.11684402
81JUN_21703547_ChIP-Seq_K562_Human1.11258907
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10239851
83AR_19668381_ChIP-Seq_PC3_Human1.09243119
84* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04764780
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04371823
86TP53_18474530_ChIP-ChIP_U2OS_Human1.04021744
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.03940288
88* RUNX2_22187159_ChIP-Seq_PCA_Human1.03665064
89HTT_18923047_ChIP-ChIP_STHdh_Human1.03621836
90ZNF274_21170338_ChIP-Seq_K562_Hela1.03080628
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02933006
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02707313
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.02164566
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02128172
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01865257
96KDM2B_26808549_Chip-Seq_REH_Human1.01053729
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00902607
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99695242
99* CJUN_26792858_Chip-Seq_BT549_Human0.99402888
100* P53_22387025_ChIP-Seq_ESCs_Mouse0.99264172
101* CMYC_18555785_Chip-Seq_ESCs_Mouse0.97954060
102* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97699677
103* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97699677
104ER_23166858_ChIP-Seq_MCF-7_Human0.97060003
105* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95539660
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.95240298
107* SOX2_18555785_Chip-Seq_ESCs_Mouse0.95154220
108WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94411513
109* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94297500
110* E2F1_18555785_Chip-Seq_ESCs_Mouse0.93619820
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93614725
112RXR_22108803_ChIP-Seq_LS180_Human0.92243835
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92117620
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91229316
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91229316
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90771439
117SOX9_26525672_Chip-Seq_HEART_Mouse0.90547256
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.90420603
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89810126
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89476596
121RING1B_27294783_Chip-Seq_NPCs_Mouse0.89392375
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89064079
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88998201
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88399300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.10348469
2MP0004859_abnormal_synaptic_plasticity4.93569946
3* MP0001968_abnormal_touch/_nociception4.54817791
4MP0002736_abnormal_nociception_after4.39362947
5MP0004270_analgesia4.35970490
6MP0002735_abnormal_chemical_nociception3.91423320
7MP0003635_abnormal_synaptic_transmissio3.62942105
8MP0002734_abnormal_mechanical_nocicepti3.28562228
9MP0002822_catalepsy3.13779327
10* MP0009745_abnormal_behavioral_response3.12489589
11MP0002733_abnormal_thermal_nociception2.96118884
12MP0002063_abnormal_learning/memory/cond2.94549993
13MP0002064_seizures2.85934070
14MP0009046_muscle_twitch2.76915835
15MP0001970_abnormal_pain_threshold2.64387390
16MP0002272_abnormal_nervous_system2.62765960
17MP0002572_abnormal_emotion/affect_behav2.60573234
18MP0006276_abnormal_autonomic_nervous2.35526013
19MP0009780_abnormal_chondrocyte_physiolo2.30781751
20* MP0002067_abnormal_sensory_capabilities2.18052263
21MP0001440_abnormal_grooming_behavior2.02985767
22MP0004858_abnormal_nervous_system1.96740751
23MP0001486_abnormal_startle_reflex1.92677424
24MP0001501_abnormal_sleep_pattern1.92251785
25MP0005423_abnormal_somatic_nervous1.91832126
26MP0008438_abnormal_cutaneous_collagen1.86669289
27MP0003879_abnormal_hair_cell1.83822769
28MP0001986_abnormal_taste_sensitivity1.81346751
29MP0002184_abnormal_innervation1.75840535
30MP0004924_abnormal_behavior1.64682374
31MP0005386_behavior/neurological_phenoty1.64682374
32MP0005646_abnormal_pituitary_gland1.60601399
33MP0003183_abnormal_peptide_metabolism1.56478577
34MP0004811_abnormal_neuron_physiology1.54907388
35MP0001944_abnormal_pancreas_morphology1.51979821
36MP0002909_abnormal_adrenal_gland1.51373927
37MP0001984_abnormal_olfaction1.50005845
38MP0002557_abnormal_social/conspecific_i1.49872269
39MP0010386_abnormal_urinary_bladder1.48694850
40MP0002837_dystrophic_cardiac_calcinosis1.48067662
41MP0003283_abnormal_digestive_organ1.46840441
42MP0000778_abnormal_nervous_system1.46744469
43MP0003329_amyloid_beta_deposits1.46302222
44MP0003633_abnormal_nervous_system1.40440909
45MP0008569_lethality_at_weaning1.38483727
46MP0001188_hyperpigmentation1.35696036
47MP0001905_abnormal_dopamine_level1.35502072
48MP0001529_abnormal_vocalization1.34845037
49MP0000955_abnormal_spinal_cord1.32798600
50MP0000003_abnormal_adipose_tissue1.28460466
51MP0003787_abnormal_imprinting1.25598818
52MP0003172_abnormal_lysosome_physiology1.23137146
53MP0000013_abnormal_adipose_tissue1.21665079
54* MP0002066_abnormal_motor_capabilities/c1.18868579
55MP0002876_abnormal_thyroid_physiology1.18829845
56MP0002882_abnormal_neuron_morphology1.18826876
57MP0003123_paternal_imprinting1.16297389
58MP0002693_abnormal_pancreas_physiology1.14927632
59MP0001502_abnormal_circadian_rhythm1.14424920
60MP0000569_abnormal_digit_pigmentation1.14144904
61MP0001756_abnormal_urination1.13888530
62MP0002295_abnormal_pulmonary_circulatio1.12344619
63MP0008874_decreased_physiological_sensi1.10872861
64MP0003122_maternal_imprinting1.10832891
65MP0008877_abnormal_DNA_methylation1.08949901
66MP0008872_abnormal_physiological_respon1.08674532
67MP0003631_nervous_system_phenotype1.06413209
68MP0006072_abnormal_retinal_apoptosis1.05999101
69MP0000751_myopathy1.04711826
70MP0000639_abnormal_adrenal_gland1.03780057
71MP0002751_abnormal_autonomic_nervous1.02111376
72MP0001958_emphysema1.01334576
73MP0010234_abnormal_vibrissa_follicle0.98712938
74MP0004085_abnormal_heartbeat0.97355536
75MP0004142_abnormal_muscle_tone0.95723231
76MP0001348_abnormal_lacrimal_gland0.95006058
77MP0010368_abnormal_lymphatic_system0.90641523
78MP0005645_abnormal_hypothalamus_physiol0.90551058
79MP0003690_abnormal_glial_cell0.87853582
80MP0001664_abnormal_digestion0.86821263
81MP0000920_abnormal_myelination0.85829266
82MP0001299_abnormal_eye_distance/0.85613572
83MP0003868_abnormal_feces_composition0.84723289
84MP0004742_abnormal_vestibular_system0.83052451
85MP0004145_abnormal_muscle_electrophysio0.82538396
86MP0002254_reproductive_system_inflammat0.82230145
87MP0005171_absent_coat_pigmentation0.82226991
88MP0004215_abnormal_myocardial_fiber0.81247414
89MP0005535_abnormal_body_temperature0.79793075
90MP0002078_abnormal_glucose_homeostasis0.79586430
91MP0002229_neurodegeneration0.79429639
92MP0002163_abnormal_gland_morphology0.78946362
93MP0005084_abnormal_gallbladder_morpholo0.77697376
94MP0002069_abnormal_eating/drinking_beha0.77419867
95MP0002152_abnormal_brain_morphology0.76078048
96MP0002638_abnormal_pupillary_reflex0.75621278
97MP0002090_abnormal_vision0.74563230
98MP0003279_aneurysm0.74279630
99MP0001963_abnormal_hearing_physiology0.73433840
100MP0005379_endocrine/exocrine_gland_phen0.73154458
101MP0004134_abnormal_chest_morphology0.72937503
102MP0002139_abnormal_hepatobiliary_system0.71653454
103MP0003075_altered_response_to0.70876217
104MP0001765_abnormal_ion_homeostasis0.69242232
105MP0004484_altered_response_of0.67502656
106MP0005332_abnormal_amino_acid0.66180537
107MP0005448_abnormal_energy_balance0.65659682
108MP0002752_abnormal_somatic_nervous0.65161541
109MP0005551_abnormal_eye_electrophysiolog0.64566482
110MP0005187_abnormal_penis_morphology0.63046821
111MP0005409_darkened_coat_color0.61516423
112MP0000604_amyloidosis0.60374972
113MP0005220_abnormal_exocrine_pancreas0.59488714
114MP0005623_abnormal_meninges_morphology0.59389207
115MP0008260_abnormal_autophagy0.58428810
116MP0000631_abnormal_neuroendocrine_gland0.58366550
117MP0008004_abnormal_stomach_pH0.58245601
118MP0001943_abnormal_respiration0.56611963
119MP0004130_abnormal_muscle_cell0.56294246
120MP0003634_abnormal_glial_cell0.55644734
121MP0002653_abnormal_ependyma_morphology0.53512649
122MP0004036_abnormal_muscle_relaxation0.53241207
123MP0004885_abnormal_endolymph0.50556387
124MP0008961_abnormal_basal_metabolism0.49239357
125MP0000230_abnormal_systemic_arterial0.48912424
126MP0000749_muscle_degeneration0.47160579
127MP0005620_abnormal_muscle_contractility0.47086393
128MP0000538_abnormal_urinary_bladder0.43863997
129MP0002972_abnormal_cardiac_muscle0.43841614
130MP0004043_abnormal_pH_regulation0.42492948
131MP0001485_abnormal_pinna_reflex0.41847409
132MP0001270_distended_abdomen0.41804605
133* MP0003956_abnormal_body_size0.41663928
134MP0003632_abnormal_nervous_system0.41166921

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.28412764
2Myokymia (HP:0002411)6.00278687
3Atonic seizures (HP:0010819)5.94095904
4Focal seizures (HP:0007359)5.91399075
5Epileptic encephalopathy (HP:0200134)5.86216746
6Hyperventilation (HP:0002883)4.95578166
7Febrile seizures (HP:0002373)4.92706178
8Absence seizures (HP:0002121)4.45344108
9Dialeptic seizures (HP:0011146)4.26863657
10Visual hallucinations (HP:0002367)4.00095333
11Generalized tonic-clonic seizures (HP:0002069)3.78797315
12Termporal pattern (HP:0011008)3.73883118
13Insidious onset (HP:0003587)3.73883118
14Hemiparesis (HP:0001269)3.67650713
15Progressive cerebellar ataxia (HP:0002073)3.59960108
16Broad-based gait (HP:0002136)3.59501380
17Amblyopia (HP:0000646)3.59350985
18Poor eye contact (HP:0000817)3.51979014
19Action tremor (HP:0002345)3.35089066
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.26365774
21Intestinal atresia (HP:0011100)3.22274532
22Gaze-evoked nystagmus (HP:0000640)3.21276335
23Pheochromocytoma (HP:0002666)3.16739362
24Cardiovascular calcification (HP:0011915)3.11944808
25Impaired pain sensation (HP:0007328)2.95463283
26Abnormality of pain sensation (HP:0010832)2.95463283
27Impaired social interactions (HP:0000735)2.92361490
28Abnormal social behavior (HP:0012433)2.92361490
29Neuroendocrine neoplasm (HP:0100634)2.90194923
30Truncal ataxia (HP:0002078)2.89384445
31Intention tremor (HP:0002080)2.88731107
32Hyperthyroidism (HP:0000836)2.87766411
33Congenital malformation of the right heart (HP:0011723)2.86020376
34Double outlet right ventricle (HP:0001719)2.86020376
35Urinary bladder sphincter dysfunction (HP:0002839)2.83368190
36Abnormal eating behavior (HP:0100738)2.78578510
37Abnormality of binocular vision (HP:0011514)2.77109579
38Diplopia (HP:0000651)2.77109579
39Vascular calcification (HP:0004934)2.76358979
40Inability to walk (HP:0002540)2.75321707
41Impaired vibration sensation in the lower limbs (HP:0002166)2.74752945
42Mitral stenosis (HP:0001718)2.71246927
43Hypothermia (HP:0002045)2.68455695
44Depression (HP:0000716)2.67510500
45Dysautonomia (HP:0002459)2.65838875
46Annular pancreas (HP:0001734)2.65701816
47Ankle clonus (HP:0011448)2.65453153
48Dysmetric saccades (HP:0000641)2.65086449
49Epileptiform EEG discharges (HP:0011182)2.64529281
50Urinary glycosaminoglycan excretion (HP:0003541)2.64053668
51Mucopolysacchariduria (HP:0008155)2.64053668
52Dysdiadochokinesis (HP:0002075)2.62210827
53Anxiety (HP:0000739)2.61178952
54Premature rupture of membranes (HP:0001788)2.54825514
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54512972
56Abnormality of polysaccharide metabolism (HP:0011012)2.54512972
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54512972
58Increased CSF protein (HP:0002922)2.53690465
59Sensory axonal neuropathy (HP:0003390)2.53371882
60Excessive salivation (HP:0003781)2.50549128
61Drooling (HP:0002307)2.50549128
62Hypoventilation (HP:0002791)2.48377225
63Ulnar claw (HP:0001178)2.47104160
64Limb dystonia (HP:0002451)2.46321402
65Supranuclear gaze palsy (HP:0000605)2.41458582
66Torticollis (HP:0000473)2.41209297
67Urinary urgency (HP:0000012)2.40190617
68Tetraplegia (HP:0002445)2.38409313
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.37534710
70Abnormal hair whorl (HP:0010721)2.37257988
71EEG with generalized epileptiform discharges (HP:0011198)2.34233414
72Abnormality of the corticospinal tract (HP:0002492)2.33956971
73Protruding tongue (HP:0010808)2.32807984
74Nuclear cataract (HP:0100018)2.30889282
75Orthostatic hypotension (HP:0001278)2.29847456
76Scanning speech (HP:0002168)2.29222366
77Hyperglycemia (HP:0003074)2.28677227
78Impaired smooth pursuit (HP:0007772)2.28488476
79Hypokinesia (HP:0002375)2.27850687
80Dysmetria (HP:0001310)2.27833775
81Failure to thrive in infancy (HP:0001531)2.26798329
82Prolonged QT interval (HP:0001657)2.25286999
83Stereotypic behavior (HP:0000733)2.20952260
84Polyphagia (HP:0002591)2.18919063
85Abnormality of vitamin B metabolism (HP:0004340)2.18764244
86Abnormality of the lower motor neuron (HP:0002366)2.17852050
87Resting tremor (HP:0002322)2.17836451
88Abnormal autonomic nervous system physiology (HP:0012332)2.16910496
89Focal dystonia (HP:0004373)2.16813454
90Abnormal EKG (HP:0003115)2.15821789
91Spastic gait (HP:0002064)2.14125005
92Hypsarrhythmia (HP:0002521)2.13661808
93Gait imbalance (HP:0002141)2.12436329
94Urethral obstruction (HP:0000796)2.12424741
95Impaired vibratory sensation (HP:0002495)2.12419653
96Akinesia (HP:0002304)2.12379879
97Craniofacial dystonia (HP:0012179)2.12220446
98Enlarged penis (HP:0000040)2.09878804
99Fetal akinesia sequence (HP:0001989)2.09595237
100Blue irides (HP:0000635)2.07938677
101Exotropia (HP:0000577)2.06731620
102Postural tremor (HP:0002174)2.04199215
103Bradykinesia (HP:0002067)2.04099980
104Status epilepticus (HP:0002133)2.03989303
105Absent speech (HP:0001344)2.03231820
106Abnormality of calcium-phosphate metabolism (HP:0100530)2.02740215
107Hypercortisolism (HP:0001578)2.02412071
108Diminished movement (HP:0002374)2.00668712
109Agitation (HP:0000713)1.99366769
110Papilledema (HP:0001085)1.99163386
111Lower limb muscle weakness (HP:0007340)1.98686284
112Myotonia (HP:0002486)1.97571094
113Progressive inability to walk (HP:0002505)1.97349290
114Bundle branch block (HP:0011710)1.95490839
115Spinal canal stenosis (HP:0003416)1.95442797
116Choreoathetosis (HP:0001266)1.95078067
117J-shaped sella turcica (HP:0002680)1.93919138
118Buphthalmos (HP:0000557)1.91237617
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90510167
120Specific learning disability (HP:0001328)1.89726954
121Gait ataxia (HP:0002066)1.87373997
122Postural instability (HP:0002172)1.86581252
123Syncope (HP:0001279)1.85732088
124Hand muscle atrophy (HP:0009130)1.85519643
125Lower limb amyotrophy (HP:0007210)1.85468844
126Congenital primary aphakia (HP:0007707)1.85377510
127Incomplete penetrance (HP:0003829)1.85269054
128Rigidity (HP:0002063)1.82537395
129Sleep apnea (HP:0010535)1.82094628
130Abnormality of dentin (HP:0010299)1.81174840
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.80850360
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80850360
133Abnormality of vitamin metabolism (HP:0100508)1.80072902
134Medial flaring of the eyebrow (HP:0010747)1.79632982
135Abnormality of salivation (HP:0100755)1.78925680
136Progressive neurologic deterioration (HP:0002344)1.78294694
137Menstrual irregularities (HP:0000858)1.78134492
138Hypoplasia of the brainstem (HP:0002365)1.77601351
139Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77601351
140Abnormality of ocular smooth pursuit (HP:0000617)1.77408693
141Zonular cataract (HP:0010920)1.77388501
142Bradycardia (HP:0001662)1.76918006
143Prominent supraorbital ridges (HP:0000336)1.76844615
144Neoplasm of the peripheral nervous system (HP:0100007)1.76768071
145Poor suck (HP:0002033)1.76467482
146Genital tract atresia (HP:0001827)1.75966669
147Clonus (HP:0002169)1.75788718
148Hemiplegia (HP:0002301)1.74149113
149Neurofibrillary tangles (HP:0002185)1.73190074
150Bowel diverticulosis (HP:0005222)1.69723205
151Delayed gross motor development (HP:0002194)1.69441861
152Protrusio acetabuli (HP:0003179)1.69344067
153Generalized myoclonic seizures (HP:0002123)1.68484578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.62687161
2EPHA44.14012182
3DAPK23.80933226
4NTRK33.60879801
5MAP3K93.04735831
6RIPK42.65463067
7MAP3K42.62793978
8NTRK12.60389659
9MAP3K122.60307668
10MAP2K72.53392156
11CCNB12.49784783
12DAPK12.28899223
13MINK12.18145488
14CDK192.04024235
15KSR21.98590869
16CAMKK21.97394185
17GRK51.93527033
18PLK21.90849380
19AKT31.81011587
20MAP2K41.79998339
21ARAF1.66646900
22PAK61.59276265
23MARK11.55240233
24FGFR21.52172192
25SIK31.43547699
26MAP3K21.43076735
27MAP2K61.40554690
28CAMKK11.36433697
29TESK11.31878688
30KSR11.31783581
31WNK31.29560194
32CDK51.25329095
33PTK21.20786943
34OXSR11.19572972
35TRPM71.18731282
36PTK2B1.16656310
37SGK2231.15468708
38SGK4941.15468708
39RET1.07700046
40PRPF4B1.07315174
41SGK21.05852897
42PRKCG1.02127767
43NTRK21.00202715
44MAPK130.99739686
45CAMK2A0.99722701
46MST40.91434811
47DAPK30.88521103
48BRAF0.86427415
49CDK140.85833056
50CDK180.83725429
51WNK40.82740827
52PRKD30.82314198
53STK38L0.80993134
54SIK20.80963009
55ALK0.79534733
56TNIK0.78350484
57UHMK10.77795964
58MAP2K10.77594474
59BMPR20.76187415
60PRKG20.76133182
61CAMK2B0.75236716
62CDK150.75046103
63MAP4K20.74962845
64ROCK10.73580999
65ROCK20.73130426
66PRKCE0.72237112
67ADRBK10.71263564
68FES0.69187310
69PRKD20.68504237
70PNCK0.68143961
71GRK10.67103922
72LATS20.66633719
73RAF10.66415691
74STK240.65414037
75MYLK0.64870420
76SGK30.64701131
77CDK11A0.63257352
78FER0.62758483
79MAP3K10.62687807
80STK390.61935151
81FRK0.61529062
82MAP3K130.59534794
83ADRBK20.59247538
84WNK10.59154881
85TSSK60.56373108
86CAMK10.55818434
87CAMK2D0.54811691
88FGFR30.54565463
89BCR0.53244440
90SGK10.52992720
91PDPK10.51704347
92TAOK10.51665481
93CAMK1G0.51141771
94STK110.49968916
95PDK30.49695750
96PDK40.49695750
97PHKG20.48499484
98PHKG10.48499484
99LMTK20.47915373
100BRSK10.46892456
101MAPK120.46417895
102CSNK1G20.46317860
103PDK10.46265367
104PAK30.45165817
105MAPK70.44897483
106RPS6KA20.44585252
107NME10.44441165
108PAK20.43990922
109PRKCI0.43515548
110CSNK1G10.41910152
111PRKG10.41467243
112PRKCH0.40681839
113DYRK1A0.40433893
114STK30.40183918
115MATK0.39940415
116CAMK2G0.39849263
117PRKCA0.39148112
118PINK10.38051593
119CAMK40.36619141
120CSNK1G30.34898073
121PRKACA0.34447301
122PRKCZ0.34161386
123FGR0.31782976
124MAPKAPK50.27665389
125CDC42BPA0.27052119
126LIMK10.26994401
127STK380.26599000
128RPS6KA30.26524682
129FYN0.25839185
130GRK70.25161894

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.83600636
2Nicotine addiction_Homo sapiens_hsa050333.35096489
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61833088
4Olfactory transduction_Homo sapiens_hsa047402.60053432
5Long-term potentiation_Homo sapiens_hsa047202.58214108
6Amphetamine addiction_Homo sapiens_hsa050312.55473013
7Circadian entrainment_Homo sapiens_hsa047132.52969719
8Morphine addiction_Homo sapiens_hsa050322.51782246
9Collecting duct acid secretion_Homo sapiens_hsa049662.46996346
10Glutamatergic synapse_Homo sapiens_hsa047242.27786368
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25614148
12GABAergic synapse_Homo sapiens_hsa047272.24601821
13Dopaminergic synapse_Homo sapiens_hsa047282.23983772
14Insulin secretion_Homo sapiens_hsa049112.19874424
15Vitamin B6 metabolism_Homo sapiens_hsa007502.19653385
16Salivary secretion_Homo sapiens_hsa049702.13414531
17Taste transduction_Homo sapiens_hsa047422.02463619
18Renin secretion_Homo sapiens_hsa049241.95229244
19Cholinergic synapse_Homo sapiens_hsa047251.83130425
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.80937067
21Serotonergic synapse_Homo sapiens_hsa047261.80386547
22Sulfur metabolism_Homo sapiens_hsa009201.78607289
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69383563
24Oxytocin signaling pathway_Homo sapiens_hsa049211.64447135
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64324512
26Cocaine addiction_Homo sapiens_hsa050301.63310539
27Long-term depression_Homo sapiens_hsa047301.63052024
28Gastric acid secretion_Homo sapiens_hsa049711.62194995
29Folate biosynthesis_Homo sapiens_hsa007901.61418781
30Vibrio cholerae infection_Homo sapiens_hsa051101.60145210
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58687100
32Calcium signaling pathway_Homo sapiens_hsa040201.56283955
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.51377078
34Gap junction_Homo sapiens_hsa045401.35958414
35GnRH signaling pathway_Homo sapiens_hsa049121.35146462
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27304731
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23060506
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22411148
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20919046
40Cardiac muscle contraction_Homo sapiens_hsa042601.19326783
41cAMP signaling pathway_Homo sapiens_hsa040241.15784589
42Estrogen signaling pathway_Homo sapiens_hsa049151.13234045
43Oxidative phosphorylation_Homo sapiens_hsa001901.13086482
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12546285
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11092560
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.09649016
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08988533
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01124695
49Phototransduction_Homo sapiens_hsa047440.99850784
50Melanogenesis_Homo sapiens_hsa049160.99601864
51Glioma_Homo sapiens_hsa052140.97525135
52Axon guidance_Homo sapiens_hsa043600.94445073
53Alzheimers disease_Homo sapiens_hsa050100.93495841
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93244602
55Protein export_Homo sapiens_hsa030600.92782739
56Type II diabetes mellitus_Homo sapiens_hsa049300.91490765
57Pancreatic secretion_Homo sapiens_hsa049720.86558632
58ErbB signaling pathway_Homo sapiens_hsa040120.83155099
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82706296
60Parkinsons disease_Homo sapiens_hsa050120.81534160
61Sphingolipid metabolism_Homo sapiens_hsa006000.80579365
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.79578556
63Dorso-ventral axis formation_Homo sapiens_hsa043200.77751295
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75241735
65Oocyte meiosis_Homo sapiens_hsa041140.73998785
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.72592286
67Thyroid hormone synthesis_Homo sapiens_hsa049180.71689255
68Arginine biosynthesis_Homo sapiens_hsa002200.70790862
69Butanoate metabolism_Homo sapiens_hsa006500.69142489
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67639155
71MAPK signaling pathway_Homo sapiens_hsa040100.67065451
72Rheumatoid arthritis_Homo sapiens_hsa053230.66963643
73Dilated cardiomyopathy_Homo sapiens_hsa054140.64906847
74Circadian rhythm_Homo sapiens_hsa047100.63609940
75Choline metabolism in cancer_Homo sapiens_hsa052310.61958698
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61757744
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.60626435
78Selenocompound metabolism_Homo sapiens_hsa004500.58583212
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58379078
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57424206
81Rap1 signaling pathway_Homo sapiens_hsa040150.57080670
82African trypanosomiasis_Homo sapiens_hsa051430.55620893
83Ras signaling pathway_Homo sapiens_hsa040140.55191292
84Glucagon signaling pathway_Homo sapiens_hsa049220.55005575
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51221209
86VEGF signaling pathway_Homo sapiens_hsa043700.51126388
87Mineral absorption_Homo sapiens_hsa049780.49795426
88Regulation of autophagy_Homo sapiens_hsa041400.48683820
89Huntingtons disease_Homo sapiens_hsa050160.46838836
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46774181
91Alcoholism_Homo sapiens_hsa050340.46339282
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46224693
93Tight junction_Homo sapiens_hsa045300.45965177
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45822126
95Phagosome_Homo sapiens_hsa041450.45165791
96Insulin signaling pathway_Homo sapiens_hsa049100.43916836
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.42636330
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42039112
99Inositol phosphate metabolism_Homo sapiens_hsa005620.41096569
100Protein digestion and absorption_Homo sapiens_hsa049740.40645037
101Ether lipid metabolism_Homo sapiens_hsa005650.39760307
102Focal adhesion_Homo sapiens_hsa045100.37325571
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36678093
104Melanoma_Homo sapiens_hsa052180.36283249
105Bile secretion_Homo sapiens_hsa049760.36157046
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35168664
107ECM-receptor interaction_Homo sapiens_hsa045120.33719729
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32629525
109Thyroid cancer_Homo sapiens_hsa052160.32430012
110beta-Alanine metabolism_Homo sapiens_hsa004100.32379394
111Endocytosis_Homo sapiens_hsa041440.31609315
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.31078617
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30429747
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28820862
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28700291
116Prion diseases_Homo sapiens_hsa050200.28192348
117Lysosome_Homo sapiens_hsa041420.28093626
118Fatty acid elongation_Homo sapiens_hsa000620.28023006
119Hippo signaling pathway_Homo sapiens_hsa043900.28000034
120Endometrial cancer_Homo sapiens_hsa052130.27871950
121mTOR signaling pathway_Homo sapiens_hsa041500.27435612
122Wnt signaling pathway_Homo sapiens_hsa043100.26466398
123Renal cell carcinoma_Homo sapiens_hsa052110.25965642
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24552704
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23321531
126Type I diabetes mellitus_Homo sapiens_hsa049400.22566312
127Ovarian steroidogenesis_Homo sapiens_hsa049130.22213563

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