RGS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)3.68673476
2peptidyl-tyrosine autophosphorylation (GO:0038083)3.48698199
3sprouting angiogenesis (GO:0002040)3.45811256
4negative regulation of blood vessel endothelial cell migration (GO:0043537)3.44518396
5angiogenesis involved in wound healing (GO:0060055)3.28302455
6basement membrane organization (GO:0071711)3.27887925
7barbed-end actin filament capping (GO:0051016)3.19025500
8protein localization to endosome (GO:0036010)3.18522916
9atrioventricular valve morphogenesis (GO:0003181)3.15930253
10lymph vessel development (GO:0001945)3.15276665
11negative regulation of potassium ion transmembrane transport (GO:1901380)3.15084512
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.11771552
13cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.09320031
14detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.05120161
15detection of temperature stimulus involved in sensory perception (GO:0050961)3.05120161
16positive regulation of endothelial cell differentiation (GO:0045603)3.01322228
17mannose metabolic process (GO:0006013)2.95943935
18cell migration involved in heart development (GO:0060973)2.95784911
19positive regulation of receptor recycling (GO:0001921)2.95589164
20retina vasculature morphogenesis in camera-type eye (GO:0061299)2.95231072
21regulation of blood vessel endothelial cell migration (GO:0043535)2.94847501
22positive thymic T cell selection (GO:0045059)2.91987748
23activated T cell proliferation (GO:0050798)2.89054729
24wound healing, spreading of cells (GO:0044319)2.87460024
25positive regulation of odontogenesis (GO:0042482)2.87452455
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82461882
27wound healing, spreading of epidermal cells (GO:0035313)2.80020119
28bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79289090
29positive regulation of interleukin-8 secretion (GO:2000484)2.77463268
30nerve growth factor signaling pathway (GO:0038180)2.77399709
31growth hormone receptor signaling pathway (GO:0060396)2.76393467
32regulation of endothelial cell differentiation (GO:0045601)2.75139520
33positive regulation of blood vessel endothelial cell migration (GO:0043536)2.72876921
34regulation of T cell tolerance induction (GO:0002664)2.71477769
35creatine metabolic process (GO:0006600)2.69272212
36muscle filament sliding (GO:0030049)2.69022243
37actin-myosin filament sliding (GO:0033275)2.69022243
38detection of temperature stimulus (GO:0016048)2.68426680
39Notch signaling involved in heart development (GO:0061314)2.67551753
40negative regulation of endothelial cell migration (GO:0010596)2.66844218
41antigen processing and presentation of endogenous antigen (GO:0019883)2.66197486
42glomerular filtration (GO:0003094)2.65353987
43plasma membrane repair (GO:0001778)2.64844249
44extracellular fibril organization (GO:0043206)2.63812338
45morphogenesis of an endothelium (GO:0003159)2.62782670
46endothelial tube morphogenesis (GO:0061154)2.62782670
47cytoskeletal anchoring at plasma membrane (GO:0007016)2.62601829
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.61186684
49thymic T cell selection (GO:0045061)2.60198240
50negative thymic T cell selection (GO:0045060)2.57946217
51negative T cell selection (GO:0043383)2.57844419
52renal filtration (GO:0097205)2.55484488
53positive regulation of vasculogenesis (GO:2001214)2.55082536
54positive regulation of endothelial cell migration (GO:0010595)2.54881430
55blood vessel maturation (GO:0001955)2.54602611
56negative regulation of inclusion body assembly (GO:0090084)2.53643250
57negative regulation of cell killing (GO:0031342)2.53428887
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53428887
59regulation of gamma-delta T cell differentiation (GO:0045586)2.51403353
60positive regulation of Rho protein signal transduction (GO:0035025)2.50362493
61axon ensheathment in central nervous system (GO:0032291)2.49062572
62central nervous system myelination (GO:0022010)2.49062572
63sarcomere organization (GO:0045214)2.49036550
64fibril organization (GO:0097435)2.48960155
65endothelium development (GO:0003158)2.48293769
66endodermal cell differentiation (GO:0035987)2.47950784
67negative regulation of stress fiber assembly (GO:0051497)2.46937197
68potassium ion import (GO:0010107)2.46237355
69regulation of endothelial cell migration (GO:0010594)2.45105935
70regulation of isotype switching to IgG isotypes (GO:0048302)2.44654471
71regulation of interleukin-8 secretion (GO:2000482)2.44438133
72response to interleukin-15 (GO:0070672)2.42218607
73activation of protein kinase A activity (GO:0034199)2.42195312
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.41714206
75positive regulation of myoblast differentiation (GO:0045663)2.41423915
76negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.41299385
77positive regulation of gamma-delta T cell activation (GO:0046645)2.40869311
78actin-mediated cell contraction (GO:0070252)2.40237254
79cellular response to growth hormone stimulus (GO:0071378)2.40070883
80positive regulation of urine volume (GO:0035810)2.39992476
81negative regulation of Rho protein signal transduction (GO:0035024)2.38280433
82actin filament depolymerization (GO:0030042)2.38148175
83positive regulation of tolerance induction (GO:0002645)2.37660767
84protein targeting to plasma membrane (GO:0072661)2.37455746
85regulation of p38MAPK cascade (GO:1900744)2.37119849
86myelin maintenance (GO:0043217)2.36769889
87cell communication involved in cardiac conduction (GO:0086065)2.36503083
88glomerular visceral epithelial cell development (GO:0072015)2.36081983
89cortical actin cytoskeleton organization (GO:0030866)2.35497932
90membrane raft organization (GO:0031579)2.35210064
91regulation of actin filament-based movement (GO:1903115)2.34754750
92enteric nervous system development (GO:0048484)2.34398576
93cell-substrate junction assembly (GO:0007044)2.33050176
94regulation of cardiac muscle cell contraction (GO:0086004)2.33008399
95regulation of natural killer cell mediated immunity (GO:0002715)2.32524418
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.32524418
97positive regulation of astrocyte differentiation (GO:0048711)2.32226803
98regulation of ARF GTPase activity (GO:0032312)2.31377011
99cardiac muscle cell proliferation (GO:0060038)2.30867742
100semaphorin-plexin signaling pathway (GO:0071526)2.30616439
101cardiac myofibril assembly (GO:0055003)2.29092189
102actin filament-based movement (GO:0030048)2.29006439
103endocardial cushion development (GO:0003197)2.27315198
104response to nerve growth factor (GO:1990089)2.27286138
105cellular response to nerve growth factor stimulus (GO:1990090)2.27286138
106positive regulation of cartilage development (GO:0061036)2.25939577
107vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.25896055
108patterning of blood vessels (GO:0001569)2.25731018
109regulation of Rho protein signal transduction (GO:0035023)2.25248450
110positive regulation of histone deacetylation (GO:0031065)2.24377064
111glomerular epithelial cell development (GO:0072310)2.22521919
112positive T cell selection (GO:0043368)2.22278880
113positive regulation of epithelial cell migration (GO:0010634)2.21623822
114heart trabecula formation (GO:0060347)2.21459301
115positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.20419197
116adherens junction assembly (GO:0034333)2.19483556
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.18660744
118antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.18660744
119cell migration involved in sprouting angiogenesis (GO:0002042)2.17925728
120blood vessel endothelial cell migration (GO:0043534)2.16348106
121negative regulation of protein autophosphorylation (GO:0031953)2.16222238
122endothelial cell chemotaxis (GO:0035767)2.15738824
123regulation of chemokine-mediated signaling pathway (GO:0070099)2.15628541
124regulation of sarcomere organization (GO:0060297)2.15541376
125cell-substrate adherens junction assembly (GO:0007045)2.15255210
126focal adhesion assembly (GO:0048041)2.15255210
127coronary vasculature morphogenesis (GO:0060977)2.14980668
128cell communication by electrical coupling (GO:0010644)2.14856562
129myofibril assembly (GO:0030239)2.14155358
130response to laminar fluid shear stress (GO:0034616)2.14110965
131endothelial cell differentiation (GO:0045446)2.13998338
132regulation of gamma-delta T cell activation (GO:0046643)2.13172157
133stress fiber assembly (GO:0043149)2.13108941
134actomyosin structure organization (GO:0031032)2.12860434
135negative regulation of actin filament bundle assembly (GO:0032232)2.11679424
136nephron epithelium development (GO:0072009)2.11642273
137sodium ion export (GO:0071436)2.11579239
138negative regulation of protein localization to cell surface (GO:2000009)2.11293934
139substrate-dependent cell migration (GO:0006929)2.11180611
140regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.11081164
141positive regulation of protein kinase C signaling (GO:0090037)2.09877502
142regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.09773893
143layer formation in cerebral cortex (GO:0021819)2.09703670
144positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.09689684
145lymphangiogenesis (GO:0001946)2.09596954
146cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.09359153
147endocytic recycling (GO:0032456)2.08514235
148positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.07679929
149endothelial cell morphogenesis (GO:0001886)2.06156831
150positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.05485030
151positive regulation of natural killer cell mediated immunity (GO:0002717)2.05485030
152arginine catabolic process (GO:0006527)2.04988044
153regulation of epithelial cell migration (GO:0010632)2.04788034
154heart valve morphogenesis (GO:0003179)2.04575962
155regulation of the force of heart contraction (GO:0002026)2.04454587
156oxygen transport (GO:0015671)2.04053109
157protein heterotrimerization (GO:0070208)2.03264569
158fibroblast migration (GO:0010761)2.03148688
159negative regulation of microtubule polymerization (GO:0031115)2.02693347
160negative regulation of neural precursor cell proliferation (GO:2000178)2.02593699
161negative regulation of potassium ion transport (GO:0043267)2.02020693
162cortical cytoskeleton organization (GO:0030865)2.01131303
163negative regulation of chondrocyte differentiation (GO:0032331)2.00814570
164regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.00634090
165cell migration in hindbrain (GO:0021535)2.00540009
166regulation of integrin-mediated signaling pathway (GO:2001044)1.99708194
167axon ensheathment (GO:0008366)1.99643263
168ensheathment of neurons (GO:0007272)1.99643263
169regulation of cell migration involved in sprouting angiogenesis (GO:0090049)1.99573254
170regulation of extracellular matrix disassembly (GO:0010715)1.99239631
171regulation of myoblast differentiation (GO:0045661)1.99026975
172venous blood vessel morphogenesis (GO:0048845)1.98894633
173platelet aggregation (GO:0070527)1.97897678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human2.72063563
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64079759
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.31950444
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22367390
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19958378
6TRIM28_21343339_ChIP-Seq_HEK293_Human1.98277375
7KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97346957
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86570179
9RUNX_20019798_ChIP-Seq_JUKART_Human1.85551813
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84228790
11DROSHA_22980978_ChIP-Seq_HELA_Human1.81641723
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79712581
13EP300_21415370_ChIP-Seq_HL-1_Mouse1.79618366
14RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76923204
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76923204
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75031057
17* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72606965
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.70540607
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.66599464
20CLOCK_20551151_ChIP-Seq_293T_Human1.66086732
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66079620
22* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60624159
23KDM2B_26808549_Chip-Seq_DND41_Human1.60605242
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60094579
25* GATA2_21666600_ChIP-Seq_HMVEC_Human1.56635994
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55436024
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53808875
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53263794
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53164939
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50013167
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.49851467
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.49851467
33KDM2B_26808549_Chip-Seq_K562_Human1.48306534
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47420270
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44196087
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43334177
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41833910
38* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40292653
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39674084
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37870789
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37780054
42* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36523630
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.36054152
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.35108045
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.34697941
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.34544745
47TP53_22127205_ChIP-Seq_IMR90_Human1.34418943
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33330875
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.32563084
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.32367106
51* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31529283
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31396040
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31360755
54LXR_22292898_ChIP-Seq_THP-1_Human1.29492928
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28778300
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27211610
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27078409
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25111614
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24668454
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.24370712
61* KDM2B_26808549_Chip-Seq_JURKAT_Human1.24169936
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23999205
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.22131124
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20628965
65VDR_21846776_ChIP-Seq_THP-1_Human1.20279049
66VDR_24763502_ChIP-Seq_THP-1_Human1.19853231
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18660424
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18651769
69* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18504975
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17968758
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.17468634
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16645062
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15439247
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15423084
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14150896
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13915359
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12970707
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.12037081
79* TP53_23651856_ChIP-Seq_MEFs_Mouse1.12001612
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11804027
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.11429306
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11346846
83SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10445388
84* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09781208
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08515536
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07362565
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07361946
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07054055
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05030382
90* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03568974
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03208932
92VDR_24787735_ChIP-Seq_THP-1_Human1.03169535
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01999965
94* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01282098
95* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00841043
96* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00576845
97* CJUN_26792858_Chip-Seq_BT549_Human1.00538517
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00425739
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99620337
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99589574
101GATA1_19941826_ChIP-Seq_K562_Human0.99374824
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99268030
103CTCF_27219007_Chip-Seq_Bcells_Human0.99112485
104AHR_22903824_ChIP-Seq_MCF-7_Human0.98723601
105SPI1_23127762_ChIP-Seq_K562_Human0.98362514
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97964779
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97055645
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96422843
109* MAF_26560356_Chip-Seq_TH1_Human0.95673278
110SMC4_20622854_ChIP-Seq_HELA_Human0.94879482
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93227399
112PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93029691
113* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92509539
114* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92509539
115* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91897268
116RING1B_27294783_Chip-Seq_ESCs_Mouse0.91577444
117RUNX1_22412390_ChIP-Seq_EML_Mouse0.91251235
118RXR_22158963_ChIP-Seq_LIVER_Mouse0.91128368
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90815217
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89640600
121* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89350965
122EZH2_22144423_ChIP-Seq_EOC_Human0.88706086
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88572040
124* BRD4_25478319_ChIP-Seq_HGPS_Human0.88404375
125TCF7_22412390_ChIP-Seq_EML_Mouse0.87502373
126* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87380092
127BCL6_27268052_Chip-Seq_Bcells_Human0.87079802
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86846927
129* UTX_26944678_Chip-Seq_JUKART_Human0.85730783
130ZNF263_19887448_ChIP-Seq_K562_Human0.84758285
131* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84399057
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84359321
133* TP63_22573176_ChIP-Seq_HFKS_Human0.83752065
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82967587
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82882279
136SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82542730
137RACK7_27058665_Chip-Seq_MCF-7_Human0.82072091
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81616531
139GATA2_19941826_ChIP-Seq_K562_Human0.81262437
140IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80269147
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80157612
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79450192
143JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79262267
144* RUNX1_27514584_Chip-Seq_MCF-7_Human0.78015907
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77996666
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77924912
147AR_21572438_ChIP-Seq_LNCaP_Human0.76474552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.38708809
2MP0002837_dystrophic_cardiac_calcinosis3.17377537
3MP0004084_abnormal_cardiac_muscle3.15227167
4MP0001879_abnormal_lymphatic_vessel2.89344157
5MP0004272_abnormal_basement_membrane2.85839649
6MP0008438_abnormal_cutaneous_collagen2.61696209
7MP0003300_gastrointestinal_ulcer2.59734658
8MP0000751_myopathy2.58153871
9MP0004185_abnormal_adipocyte_glucose2.55454361
10MP0003279_aneurysm2.53148210
11MP0005167_abnormal_blood-brain_barrier2.52126116
12MP0005623_abnormal_meninges_morphology2.38387912
13MP0000013_abnormal_adipose_tissue2.27279187
14MP0004036_abnormal_muscle_relaxation2.22226621
15MP0004510_myositis2.06096871
16MP0002138_abnormal_hepatobiliary_system2.01261464
17MP0002735_abnormal_chemical_nociception1.99111482
18MP0004215_abnormal_myocardial_fiber1.89381007
19MP0005666_abnormal_adipose_tissue1.89366217
20MP0003191_abnormal_cellular_cholesterol1.81137123
21MP0003045_fibrosis1.79165335
22MP0004130_abnormal_muscle_cell1.78459190
23MP0002933_joint_inflammation1.71487763
24MP0005375_adipose_tissue_phenotype1.71313529
25MP0001958_emphysema1.69612048
26MP0003828_pulmonary_edema1.66057132
27MP0003724_increased_susceptibility_to1.62837370
28MP0001968_abnormal_touch/_nociception1.62484489
29MP0000750_abnormal_muscle_regeneration1.60673295
30MP0000003_abnormal_adipose_tissue1.58436806
31MP0008775_abnormal_heart_ventricle1.57337843
32MP0000920_abnormal_myelination1.53324071
33MP0005451_abnormal_body_composition1.51218302
34MP0003436_decreased_susceptibility_to1.50342464
35MP0002127_abnormal_cardiovascular_syste1.45494954
36MP0002972_abnormal_cardiac_muscle1.44995187
37MP0002332_abnormal_exercise_endurance1.44824777
38MP0001542_abnormal_bone_strength1.42785183
39MP0002736_abnormal_nociception_after1.42671240
40MP0005670_abnormal_white_adipose1.41383224
41MP0004858_abnormal_nervous_system1.41305009
42MP0006138_congestive_heart_failure1.41065749
43MP0008260_abnormal_autophagy1.40595641
44MP0005410_abnormal_fertilization1.39061558
45MP0000465_gastrointestinal_hemorrhage1.38350390
46MP0005330_cardiomyopathy1.37810983
47MP0003091_abnormal_cell_migration1.37581805
48MP0004085_abnormal_heartbeat1.34623865
49MP0000767_abnormal_smooth_muscle1.34007285
50MP0004087_abnormal_muscle_fiber1.31555207
51MP0005275_abnormal_skin_tensile1.28956475
52MP0003705_abnormal_hypodermis_morpholog1.28365427
53MP0003950_abnormal_plasma_membrane1.26085484
54MP0000733_abnormal_muscle_development1.25284010
55MP0005671_abnormal_response_to1.24992089
56MP0005023_abnormal_wound_healing1.24499259
57MP0004270_analgesia1.24076346
58MP0003566_abnormal_cell_adhesion1.22326177
59MP0005385_cardiovascular_system_phenoty1.21996214
60MP0001544_abnormal_cardiovascular_syste1.21996214
61MP0002733_abnormal_thermal_nociception1.21540479
62MP0009278_abnormal_bone_marrow1.21123493
63MP0010630_abnormal_cardiac_muscle1.20062539
64MP0008961_abnormal_basal_metabolism1.19062307
65MP0005503_abnormal_tendon_morphology1.16242298
66MP0005620_abnormal_muscle_contractility1.15990389
67MP0005464_abnormal_platelet_physiology1.15758962
68MP0001851_eye_inflammation1.15569141
69MP0010030_abnormal_orbit_morphology1.14750321
70MP0001970_abnormal_pain_threshold1.14625830
71MP0003137_abnormal_impulse_conducting1.14615061
72MP0005083_abnormal_biliary_tract1.13827203
73MP0005165_increased_susceptibility_to1.13765099
74MP0000749_muscle_degeneration1.11408718
75MP0002106_abnormal_muscle_physiology1.08571837
76MP0003763_abnormal_thymus_physiology1.08277500
77MP0005595_abnormal_vascular_smooth1.05549046
78MP0002734_abnormal_mechanical_nocicepti1.04930879
79MP0002998_abnormal_bone_remodeling1.04782618
80MP0005390_skeleton_phenotype1.04335590
81MP0003303_peritoneal_inflammation1.04318060
82MP0004233_abnormal_muscle_weight1.04294158
83MP0001270_distended_abdomen1.03594597
84MP0005257_abnormal_intraocular_pressure1.02962059
85MP0003866_abnormal_defecation1.02573265
86MP0003329_amyloid_beta_deposits1.01110908
87MP0005369_muscle_phenotype1.01023526
88MP0002909_abnormal_adrenal_gland1.01018328
89MP0004484_altered_response_of1.00980172
90MP0000747_muscle_weakness0.99830702
91MP0000759_abnormal_skeletal_muscle0.96901743
92MP0000249_abnormal_blood_vessel0.96832769
93MP0002295_abnormal_pulmonary_circulatio0.96470970
94MP0001348_abnormal_lacrimal_gland0.96057708
95MP0000230_abnormal_systemic_arterial0.95705014
96MP0000343_altered_response_to0.93904123
97MP0002896_abnormal_bone_mineralization0.93149902
98MP0005409_darkened_coat_color0.91424108
99MP0004145_abnormal_muscle_electrophysio0.88691394
100MP0003633_abnormal_nervous_system0.88578848
101MP0002877_abnormal_melanocyte_morpholog0.88011824
102MP0005164_abnormal_response_to0.87912031
103MP0009384_cardiac_valve_regurgitation0.86469967
104MP0001299_abnormal_eye_distance/0.86372869
105MP0002128_abnormal_blood_circulation0.85692887
106MP0009840_abnormal_foam_cell0.85377044
107MP0000858_altered_metastatic_potential0.85212470
108MP0001849_ear_inflammation0.84359464
109MP0002133_abnormal_respiratory_system0.84019741
110MP0005388_respiratory_system_phenotype0.84019741
111MP0005508_abnormal_skeleton_morphology0.83354793
112MP0001873_stomach_inflammation0.83159461
113MP0003646_muscle_fatigue0.80964145
114MP0006054_spinal_hemorrhage0.79206183
115MP0002419_abnormal_innate_immunity0.79132760
116MP0005360_urolithiasis0.78283675
117MP0001915_intracranial_hemorrhage0.77145692
118MP0002269_muscular_atrophy0.77098777
119MP0003634_abnormal_glial_cell0.76049830
120MP0006276_abnormal_autonomic_nervous0.74033513
121MP0001533_abnormal_skeleton_physiology0.73186414
122MP0000534_abnormal_ureter_morphology0.72660934
123MP0002168_other_aberrant_phenotype0.72584776
124MP0000266_abnormal_heart_morphology0.72422848
125MP0003283_abnormal_digestive_organ0.71912639
126MP0000685_abnormal_immune_system0.71882591
127MP0004883_abnormal_blood_vessel0.71766561
128MP0005025_abnormal_response_to0.70628281
129MP0003385_abnormal_body_wall0.70146958
130MP0008569_lethality_at_weaning0.70053109
131MP0002925_abnormal_cardiovascular_devel0.69831811
132MP0004147_increased_porphyrin_level0.68676742
133MP0000462_abnormal_digestive_system0.67887568
134MP0002166_altered_tumor_susceptibility0.67775704
135MP0002108_abnormal_muscle_morphology0.66828613
136MP0008874_decreased_physiological_sensi0.66494783
137MP0009780_abnormal_chondrocyte_physiolo0.65933572
138MP0001614_abnormal_blood_vessel0.65555304

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)4.33283128
2Hyporeflexia of lower limbs (HP:0002600)4.27369656
3Muscle fiber splitting (HP:0003555)3.97253076
4Sudden death (HP:0001699)3.77583231
5Type 1 muscle fiber predominance (HP:0003803)3.64534488
6Difficulty running (HP:0009046)3.57969587
7Cerebral aneurysm (HP:0004944)3.47571089
8Wrist flexion contracture (HP:0001239)3.44317671
9Abnormality of the nasal mucosa (HP:0000433)3.42277170
10Distal lower limb muscle weakness (HP:0009053)3.17732561
11Aortic aneurysm (HP:0004942)3.16616430
12Cervical subluxation (HP:0003308)3.00684481
13Protrusio acetabuli (HP:0003179)2.96957045
14Aortic dissection (HP:0002647)2.92738188
15Ventricular tachycardia (HP:0004756)2.86038110
16Onion bulb formation (HP:0003383)2.81792637
17Mildly elevated creatine phosphokinase (HP:0008180)2.75163485
18Cerebral hemorrhage (HP:0001342)2.70538812
19Premature rupture of membranes (HP:0001788)2.64906375
20Increased variability in muscle fiber diameter (HP:0003557)2.62795268
21Atrial fibrillation (HP:0005110)2.60367417
22Myotonia (HP:0002486)2.59773008
23Nasal polyposis (HP:0100582)2.53568503
24Menorrhagia (HP:0000132)2.52103210
25Distal lower limb amyotrophy (HP:0008944)2.49603948
26Spontaneous hematomas (HP:0007420)2.48038034
27Segmental peripheral demyelination/remyelination (HP:0003481)2.46497093
28Primary atrial arrhythmia (HP:0001692)2.45078040
29Prolonged QT interval (HP:0001657)2.45066164
30Ulnar claw (HP:0001178)2.43673379
31Bladder diverticulum (HP:0000015)2.38520105
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37824845
33Supraventricular arrhythmia (HP:0005115)2.37699439
34Esophageal varix (HP:0002040)2.35634557
35EMG: myopathic abnormalities (HP:0003458)2.33251684
36Round ear (HP:0100830)2.32883218
37Foot dorsiflexor weakness (HP:0009027)2.32305739
38Nemaline bodies (HP:0003798)2.32110284
39Disproportionate tall stature (HP:0001519)2.31351165
40Hematochezia (HP:0002573)2.30743145
41Blue sclerae (HP:0000592)2.29786695
42Muscle fiber inclusion bodies (HP:0100299)2.28314646
43Increased connective tissue (HP:0009025)2.27697719
44Hypercortisolism (HP:0001578)2.26038381
45Vascular tortuosity (HP:0004948)2.25781017
46Supraventricular tachycardia (HP:0004755)2.25343531
47Arterial tortuosity (HP:0005116)2.25337045
48Lipoatrophy (HP:0100578)2.24860932
49Shallow orbits (HP:0000586)2.24394720
50Visceral angiomatosis (HP:0100761)2.24241413
51Glucose intolerance (HP:0000833)2.24053985
52Hemiplegia (HP:0002301)2.23952915
53Insidious onset (HP:0003587)2.23126248
54Termporal pattern (HP:0011008)2.23126248
55Aneurysm (HP:0002617)2.22364855
56Mitral valve prolapse (HP:0001634)2.22236157
57Abnormality of skeletal muscle fiber size (HP:0012084)2.20178233
58Bundle branch block (HP:0011710)2.20031822
59Lymphangioma (HP:0100764)2.19523320
60Scapular winging (HP:0003691)2.19117565
61Vertebral compression fractures (HP:0002953)2.18798808
62Abnormality of the foot musculature (HP:0001436)2.16951374
63Ulnar deviation of the wrist (HP:0003049)2.16584966
64Polycythemia (HP:0001901)2.16030109
65Hypoplasia of the iris (HP:0007676)2.15355186
66Broad face (HP:0000283)2.14054596
67Syncope (HP:0001279)2.13416396
68Exercise-induced myalgia (HP:0003738)2.13397407
69Hemorrhage of the eye (HP:0011885)2.08652364
70Myositis (HP:0100614)2.08066335
71Asymmetric septal hypertrophy (HP:0001670)2.06953737
72Joint stiffness (HP:0001387)2.06344202
73Hemangiomatosis (HP:0007461)2.04591636
74Hammertoe (HP:0001765)2.03848803
75Elevated erythrocyte sedimentation rate (HP:0003565)2.00790854
76Spondylolisthesis (HP:0003302)1.99272515
77Persistence of primary teeth (HP:0006335)1.98504178
78Action tremor (HP:0002345)1.98409400
79Striae distensae (HP:0001065)1.98368154
80Hyperacusis (HP:0010780)1.97048666
81Short nail (HP:0001799)1.96893714
82Lumbar hyperlordosis (HP:0002938)1.94587070
83Ankle contracture (HP:0006466)1.93846830
84Atrioventricular block (HP:0001678)1.93404152
85Ventricular fibrillation (HP:0001663)1.93029282
86Soft skin (HP:0000977)1.92728375
87Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92701872
88Rapidly progressive (HP:0003678)1.92682396
89Flexion contracture of toe (HP:0005830)1.92183504
90Joint contractures involving the joints of the feet (HP:0100492)1.92183504
91Neurofibrillary tangles (HP:0002185)1.90966660
92Coxa vara (HP:0002812)1.90689270
93Neck muscle weakness (HP:0000467)1.90408722
94Pheochromocytoma (HP:0002666)1.90295593
95Right ventricular cardiomyopathy (HP:0011663)1.86776926
96Supranuclear gaze palsy (HP:0000605)1.86368483
97Interstitial pulmonary disease (HP:0006530)1.85332449
98Aortic valve stenosis (HP:0001650)1.85309305
99Heart block (HP:0012722)1.84937498
100Joint laxity (HP:0001388)1.84521298
101Broad ribs (HP:0000885)1.83839904
102Orchitis (HP:0100796)1.83427313
103Mesangial abnormality (HP:0001966)1.83138633
104Hip contracture (HP:0003273)1.82782139
105Overgrowth (HP:0001548)1.82077792
106Sudden cardiac death (HP:0001645)1.80976395
107Limited hip movement (HP:0008800)1.80320761
108Short hallux (HP:0010109)1.79866317
109Abnormality of the ischium (HP:0003174)1.79472472
110Calf muscle hypertrophy (HP:0008981)1.77218048
111Ankle clonus (HP:0011448)1.77079013
112Atrophic scars (HP:0001075)1.76070266
113Buphthalmos (HP:0000557)1.75936717
114Limb-girdle muscle atrophy (HP:0003797)1.75843421
115Centrally nucleated skeletal muscle fibers (HP:0003687)1.75806202
116Emphysema (HP:0002097)1.75802770
117Mitral stenosis (HP:0001718)1.75780790
118Bradycardia (HP:0001662)1.75661733
119Stridor (HP:0010307)1.75368897
120Abnormality of the calf musculature (HP:0001430)1.74401208
121Abnormal atrioventricular conduction (HP:0005150)1.74183299
122Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.73524775
123Pulmonary hypertension (HP:0002092)1.73065658
124Long toe (HP:0010511)1.72057557
125Venous abnormality (HP:0002624)1.71637679
126Epistaxis (HP:0000421)1.71579475
127Portal hypertension (HP:0001409)1.71280923
128Lower limb amyotrophy (HP:0007210)1.70490274
129Camptodactyly of toe (HP:0001836)1.70029006
130Ectopia lentis (HP:0001083)1.69884900
131Upper limb amyotrophy (HP:0009129)1.69595702
132Distal upper limb amyotrophy (HP:0007149)1.69595702
133Bowel diverticulosis (HP:0005222)1.68730669
134Dilatation of the ascending aorta (HP:0005111)1.68345753
135Prolonged bleeding time (HP:0003010)1.67927788
136Hyperextensible skin (HP:0000974)1.67541439
137Nonimmune hydrops fetalis (HP:0001790)1.67135145
138Eczematoid dermatitis (HP:0000976)1.66447169
139Abnormality of the peritoneum (HP:0002585)1.66420692
140Wormian bones (HP:0002645)1.66218245
141Chest pain (HP:0100749)1.65797085
142Peritonitis (HP:0002586)1.65645112
143Difficulty climbing stairs (HP:0003551)1.65331107
144Dilated cardiomyopathy (HP:0001644)1.64525848
145Hypoplastic ischia (HP:0003175)1.64139357
146Muscle stiffness (HP:0003552)1.63451546
147Spinal rigidity (HP:0003306)1.62990379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.71229033
2KDR3.38020458
3ERN13.05736388
4EPHB12.94849203
5TRIB32.86053208
6STK392.26806029
7RIPK12.20758951
8LMTK22.03446250
9FGFR41.88420657
10NTRK11.80168766
11TGFBR21.77029949
12EPHB21.77004339
13EPHA21.76665159
14TTN1.74141965
15PRKD31.73894574
16MAP4K11.69621546
17ITK1.66747488
18TESK21.63964509
19EPHA31.63732704
20WNK41.60208230
21FES1.54299915
22PTK61.53882002
23TYRO31.53699832
24PDGFRA1.44732939
25PHKG21.44564894
26PHKG11.44564894
27PTK2B1.43903915
28JAK11.39866366
29TXK1.39787154
30ICK1.33999631
31CSK1.33225090
32FGFR21.30912539
33MAP3K61.26930559
34PRKCH1.25917109
35DMPK1.25848628
36LIMK11.23497584
37PKN11.22553685
38DDR21.21805523
39NEK91.21735317
40MYLK1.21213134
41PIK3CG1.20925590
42WNK11.20741036
43RET1.19377812
44MOS1.17530767
45TNK21.15252892
46CAMK1G1.14565122
47PRKG21.12544111
48PRKD11.11546880
49ZAP701.09406743
50JAK31.08323336
51SIK11.06543752
52PTK21.03707569
53MAP3K111.03497845
54TRPM71.03279010
55OBSCN1.02697454
56PKN21.02489718
57MAP3K31.02265720
58PAK61.01247094
59TYK21.01240922
60PRPF4B1.00200067
61MARK20.99403534
62FGFR30.99277445
63KSR20.99127022
64MAPK70.98612688
65RPS6KA20.98093543
66PDGFRB0.97676011
67STK380.97445145
68FER0.93826490
69MAPK150.92353889
70PAK40.92304664
71BLK0.92235723
72DYRK1B0.90431976
73MARK30.89127500
74PAK30.88663359
75LRRK20.87945922
76TESK10.87649217
77MATK0.86164557
78MAP3K70.85190407
79ILK0.83812508
80CAMK1D0.83273062
81ROCK20.82133528
82HCK0.77733422
83PRKD20.76540672
84MAPKAPK30.74741733
85PIM20.74301477
86MUSK0.71851224
87CDC42BPA0.69724335
88PDPK10.66947100
89ROCK10.66403896
90TGFBR10.66390769
91GRK60.65557231
92TAOK30.65412946
93BTK0.65028898
94PDK10.64724599
95LCK0.64504085
96PRKAA20.63321786
97SIK20.62954859
98MAP3K10.62284158
99BCKDK0.62254284
100MAP2K20.62150422
101TAOK10.60627912
102CDK80.60299658
103KIT0.59834606
104PRKCQ0.58753497
105RPS6KL10.58681470
106RPS6KC10.58681470
107STK110.58415878
108SGK2230.58038177
109SGK4940.58038177
110MAPK120.56472212
111STK100.56175493
112PAK20.56156553
113IRAK40.52826241
114MAPK110.52465871
115JAK20.49872661
116GSK3A0.49324459
117SRC0.48276237
118MAP2K30.48268188
119GRK50.48132834
120FYN0.48121267
121RPS6KA60.46965691
122INSR0.46753264
123MAP3K130.46535602
124NLK0.46512824
125MET0.46410710
126FLT30.46159597
127IGF1R0.45772843
128BMX0.44273918
129EEF2K0.44089847
130IKBKE0.44073872
131CSNK1A1L0.43941714
132TBK10.43392049
133PDK20.43286012
134HIPK20.42659485
135MAPKAPK20.42596774
136FGR0.42431460
137PDK30.42378913
138PDK40.42378913
139DAPK30.40951914
140ADRBK10.39835261

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.17982372
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.89218871
3Glycosaminoglycan degradation_Homo sapiens_hsa005311.78507444
4Dilated cardiomyopathy_Homo sapiens_hsa054141.75240644
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55523603
6Focal adhesion_Homo sapiens_hsa045101.53757657
7ECM-receptor interaction_Homo sapiens_hsa045121.53564581
8Dorso-ventral axis formation_Homo sapiens_hsa043201.50831531
9Viral myocarditis_Homo sapiens_hsa054161.50468204
10T cell receptor signaling pathway_Homo sapiens_hsa046601.46389865
11VEGF signaling pathway_Homo sapiens_hsa043701.43346596
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41377817
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38711096
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31699936
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.31437048
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28792266
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28453346
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24941030
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24584775
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24140758
21* Axon guidance_Homo sapiens_hsa043601.24114425
22Estrogen signaling pathway_Homo sapiens_hsa049151.19213944
23cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15778069
24Rap1 signaling pathway_Homo sapiens_hsa040151.13509266
25Renal cell carcinoma_Homo sapiens_hsa052111.12580609
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.11900950
27Renin secretion_Homo sapiens_hsa049241.07363651
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07086775
29Complement and coagulation cascades_Homo sapiens_hsa046101.06639266
30Platelet activation_Homo sapiens_hsa046111.06385983
31Small cell lung cancer_Homo sapiens_hsa052221.06170830
32Phospholipase D signaling pathway_Homo sapiens_hsa040721.04660818
33Endocytosis_Homo sapiens_hsa041441.03656835
34Gastric acid secretion_Homo sapiens_hsa049711.01590132
35Insulin resistance_Homo sapiens_hsa049311.00672598
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96413710
37Gap junction_Homo sapiens_hsa045400.95080322
38Type II diabetes mellitus_Homo sapiens_hsa049300.94391376
39Adipocytokine signaling pathway_Homo sapiens_hsa049200.94378824
40Toxoplasmosis_Homo sapiens_hsa051450.94265909
41Chemokine signaling pathway_Homo sapiens_hsa040620.94071285
42Amoebiasis_Homo sapiens_hsa051460.93190184
43Insulin secretion_Homo sapiens_hsa049110.93015681
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92929101
45Adherens junction_Homo sapiens_hsa045200.92729630
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.92218406
47Cholinergic synapse_Homo sapiens_hsa047250.90302540
48Bladder cancer_Homo sapiens_hsa052190.90245091
49Apoptosis_Homo sapiens_hsa042100.90067876
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90053652
51Fructose and mannose metabolism_Homo sapiens_hsa000510.89443423
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88789941
53Cardiac muscle contraction_Homo sapiens_hsa042600.88262717
54Leishmaniasis_Homo sapiens_hsa051400.88123464
55Protein digestion and absorption_Homo sapiens_hsa049740.87597541
56Salivary secretion_Homo sapiens_hsa049700.87028785
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86897829
58Osteoclast differentiation_Homo sapiens_hsa043800.86561694
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85412369
60Proteoglycans in cancer_Homo sapiens_hsa052050.84357080
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83541812
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83339797
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82562440
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82311170
65cAMP signaling pathway_Homo sapiens_hsa040240.81202613
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.80834893
67Tight junction_Homo sapiens_hsa045300.80359029
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79695784
69GnRH signaling pathway_Homo sapiens_hsa049120.78100531
70Prolactin signaling pathway_Homo sapiens_hsa049170.77828329
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.76643738
72Pancreatic cancer_Homo sapiens_hsa052120.76212076
73Chronic myeloid leukemia_Homo sapiens_hsa052200.75572248
74Ras signaling pathway_Homo sapiens_hsa040140.75178306
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75076852
76Oxytocin signaling pathway_Homo sapiens_hsa049210.74602392
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74315614
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73588679
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73022975
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72922209
81Fatty acid biosynthesis_Homo sapiens_hsa000610.72842751
82Measles_Homo sapiens_hsa051620.72722434
83Insulin signaling pathway_Homo sapiens_hsa049100.72675475
84PPAR signaling pathway_Homo sapiens_hsa033200.72251776
85Fatty acid metabolism_Homo sapiens_hsa012120.71440199
86Olfactory transduction_Homo sapiens_hsa047400.71419041
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70760564
88MAPK signaling pathway_Homo sapiens_hsa040100.70566514
89Thyroid hormone synthesis_Homo sapiens_hsa049180.69649362
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69562506
91Phagosome_Homo sapiens_hsa041450.69452466
92Pathways in cancer_Homo sapiens_hsa052000.69317121
93Hepatitis C_Homo sapiens_hsa051600.69246132
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68883949
95Prion diseases_Homo sapiens_hsa050200.68635730
96Other glycan degradation_Homo sapiens_hsa005110.67825090
97Salmonella infection_Homo sapiens_hsa051320.67235336
98Bile secretion_Homo sapiens_hsa049760.67157900
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67023679
100Morphine addiction_Homo sapiens_hsa050320.66951787
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66413791
102Shigellosis_Homo sapiens_hsa051310.64481973
103Acute myeloid leukemia_Homo sapiens_hsa052210.63818751
104Pertussis_Homo sapiens_hsa051330.63071893
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.62510624
106Graft-versus-host disease_Homo sapiens_hsa053320.62468980
107B cell receptor signaling pathway_Homo sapiens_hsa046620.61958440
108Cocaine addiction_Homo sapiens_hsa050300.61782210
109HIF-1 signaling pathway_Homo sapiens_hsa040660.61203741
110Propanoate metabolism_Homo sapiens_hsa006400.60569141
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60488223
112Choline metabolism in cancer_Homo sapiens_hsa052310.60231785
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60129361
114Pancreatic secretion_Homo sapiens_hsa049720.60083567
115Hepatitis B_Homo sapiens_hsa051610.59916873
116Notch signaling pathway_Homo sapiens_hsa043300.59817504
117AMPK signaling pathway_Homo sapiens_hsa041520.59784519
118TNF signaling pathway_Homo sapiens_hsa046680.59623884
119Hematopoietic cell lineage_Homo sapiens_hsa046400.59094547
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58372277
121Circadian entrainment_Homo sapiens_hsa047130.57865422
122Melanogenesis_Homo sapiens_hsa049160.57412919
123Primary immunodeficiency_Homo sapiens_hsa053400.57291472
124Staphylococcus aureus infection_Homo sapiens_hsa051500.57287135
125Ovarian steroidogenesis_Homo sapiens_hsa049130.57210252
126Malaria_Homo sapiens_hsa051440.56646161
127Endometrial cancer_Homo sapiens_hsa052130.56621211
128Non-small cell lung cancer_Homo sapiens_hsa052230.56208752
129Fatty acid degradation_Homo sapiens_hsa000710.56075461
130Dopaminergic synapse_Homo sapiens_hsa047280.53809102
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53274195
132Nitrogen metabolism_Homo sapiens_hsa009100.52855795
133Galactose metabolism_Homo sapiens_hsa000520.52556035
134Influenza A_Homo sapiens_hsa051640.50303763
135FoxO signaling pathway_Homo sapiens_hsa040680.49067646
136Tuberculosis_Homo sapiens_hsa051520.49025381
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48141479
138Allograft rejection_Homo sapiens_hsa053300.46532877

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