RGS18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)7.49786443
2ribosomal small subunit assembly (GO:0000028)6.91343330
3definitive hemopoiesis (GO:0060216)6.61875145
4protein neddylation (GO:0045116)5.96308284
5platelet dense granule organization (GO:0060155)5.94366386
6regulation of platelet aggregation (GO:0090330)5.75517171
7leukocyte migration involved in inflammatory response (GO:0002523)5.59414934
8regulation of platelet activation (GO:0010543)5.49584822
9positive regulation of mast cell activation (GO:0033005)5.46167109
10platelet aggregation (GO:0070527)4.93261403
11neutrophil activation (GO:0042119)4.83836264
12megakaryocyte development (GO:0035855)4.82845682
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80694667
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.71834741
15adenosine receptor signaling pathway (GO:0001973)4.68295076
16blood coagulation, intrinsic pathway (GO:0007597)4.57217481
17angiogenesis involved in wound healing (GO:0060055)4.45270899
18viral transcription (GO:0019083)4.30268619
19response to interferon-beta (GO:0035456)4.29188344
20DNA deamination (GO:0045006)4.28388504
21granulocyte activation (GO:0036230)4.27048520
22negative regulation of homotypic cell-cell adhesion (GO:0034111)4.24003986
23telomere maintenance via semi-conservative replication (GO:0032201)4.20572683
24lymphoid progenitor cell differentiation (GO:0002320)4.12048036
25translational termination (GO:0006415)4.11243970
26polyketide metabolic process (GO:0030638)4.10140943
27doxorubicin metabolic process (GO:0044598)4.10140943
28daunorubicin metabolic process (GO:0044597)4.10140943
29negative regulation of norepinephrine secretion (GO:0010700)4.04178601
30regulation of integrin activation (GO:0033623)3.95619985
31positive regulation of B cell differentiation (GO:0045579)3.93981184
32negative regulation of platelet activation (GO:0010544)3.92920601
33antigen processing and presentation via MHC class Ib (GO:0002475)3.92816590
34regulation of integrin-mediated signaling pathway (GO:2001044)3.87764839
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.86645526
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.86645526
37purinergic nucleotide receptor signaling pathway (GO:0035590)3.85692532
38endosome to melanosome transport (GO:0035646)3.85679575
39endosome to pigment granule transport (GO:0043485)3.85679575
40DNA strand elongation involved in DNA replication (GO:0006271)3.85503611
41DNA strand elongation (GO:0022616)3.83381053
42positive regulation of endothelial cell differentiation (GO:0045603)3.79621516
43telomere maintenance via recombination (GO:0000722)3.78998531
44ribosomal small subunit biogenesis (GO:0042274)3.78913896
45secretory granule organization (GO:0033363)3.78217446
46lipoxygenase pathway (GO:0019372)3.78139913
47regulation of mast cell activation (GO:0033003)3.76994516
48negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.75984336
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.72407892
50microglial cell activation (GO:0001774)3.67488285
51homotypic cell-cell adhesion (GO:0034109)3.66049971
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.65794843
53translational elongation (GO:0006414)3.65430980
54cotranslational protein targeting to membrane (GO:0006613)3.65011404
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.61958924
56mast cell activation (GO:0045576)3.60909127
57protein targeting to ER (GO:0045047)3.59873081
58defense response to protozoan (GO:0042832)3.58108787
59positive regulation of hemostasis (GO:1900048)3.56860307
60positive regulation of blood coagulation (GO:0030194)3.56860307
61negative regulation of phagocytosis (GO:0050765)3.56804463
62platelet degranulation (GO:0002576)3.55471974
63positive regulation of mast cell degranulation (GO:0043306)3.54073447
64positive regulation of mast cell activation involved in immune response (GO:0033008)3.54073447
65regulation of lipoprotein metabolic process (GO:0050746)3.54071141
66regulation of mast cell degranulation (GO:0043304)3.52465822
67G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.50283275
68production of molecular mediator involved in inflammatory response (GO:0002532)3.49825568
69maturation of SSU-rRNA (GO:0030490)3.47431794
70protein localization to endoplasmic reticulum (GO:0070972)3.46478539
71leukocyte degranulation (GO:0043299)3.44647182
72response to protozoan (GO:0001562)3.41976018
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41817483
74platelet activation (GO:0030168)3.41094390
75regulation of homotypic cell-cell adhesion (GO:0034110)3.39681437
76negative regulation of erythrocyte differentiation (GO:0045647)3.38713903
77myeloid cell activation involved in immune response (GO:0002275)3.38587309
78negative regulation of thymocyte apoptotic process (GO:0070244)3.38497608
79regulation of mast cell activation involved in immune response (GO:0033006)3.37290104
80mitotic recombination (GO:0006312)3.34471927
81regulation of regulatory T cell differentiation (GO:0045589)3.33863803
82phospholipid scrambling (GO:0017121)3.33630043
83platelet formation (GO:0030220)3.30480617
84regulation of Golgi to plasma membrane protein transport (GO:0042996)3.30095628
85modulation by symbiont of host immune response (GO:0052553)3.27166755
86positive regulation by symbiont of host defense response (GO:0052509)3.27166755
87modulation by symbiont of host defense response (GO:0052031)3.27166755
88modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.27166755
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.27166755
90positive regulation by organism of defense response of other organism involved in symbiotic interact3.27166755
91mature B cell differentiation involved in immune response (GO:0002313)3.27166311
92antigen processing and presentation of endogenous antigen (GO:0019883)3.26404448
93cellular extravasation (GO:0045123)3.26332460
94purinergic receptor signaling pathway (GO:0035587)3.26193774
95negative regulation of interleukin-17 production (GO:0032700)3.26012004
96positive regulation of gamma-delta T cell activation (GO:0046645)3.25845027
97positive regulation of coagulation (GO:0050820)3.23970444
98thrombin receptor signaling pathway (GO:0070493)3.23159657
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.22577848
100negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22011395
101negative regulation of cell killing (GO:0031342)3.22011395
102negative regulation of heart rate (GO:0010459)3.19675498
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18283167
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17399860
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15914621
106viral life cycle (GO:0019058)3.15055601
107positive regulation of B cell mediated immunity (GO:0002714)3.12525172
108positive regulation of immunoglobulin mediated immune response (GO:0002891)3.12525172
109dendritic cell chemotaxis (GO:0002407)3.11918174
110deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.11484549
111positive regulation of receptor recycling (GO:0001921)3.10565113
112necroptotic process (GO:0070266)3.09494545
113regulation of erythrocyte differentiation (GO:0045646)3.09350844
114telomere maintenance via telomere lengthening (GO:0010833)3.08950786
115mast cell activation involved in immune response (GO:0002279)3.07916498
116mast cell degranulation (GO:0043303)3.07916498
117cellular protein complex disassembly (GO:0043624)3.06735624
118heparin biosynthetic process (GO:0030210)3.02538124
119heparin metabolic process (GO:0030202)3.02538124
120phagocytosis, engulfment (GO:0006911)3.01625553
121regulation of B cell differentiation (GO:0045577)3.00463399
122DNA replication initiation (GO:0006270)2.98726126
123low-density lipoprotein particle remodeling (GO:0034374)2.98394007
124regulation of memory T cell differentiation (GO:0043380)2.97924657
125T cell homeostasis (GO:0043029)2.97135484
126positive regulation of Rho protein signal transduction (GO:0035025)2.96294047
127regulation of T-helper 2 cell differentiation (GO:0045628)2.95005026
128regulation of macrophage derived foam cell differentiation (GO:0010743)2.92656772
129lymph node development (GO:0048535)2.91830776
130autophagic vacuole fusion (GO:0000046)2.91502792
131regulation of MHC class II biosynthetic process (GO:0045346)2.91308458
132positive regulation of granulocyte differentiation (GO:0030854)2.91175450
133CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.90967996
134positive regulation of cAMP-mediated signaling (GO:0043950)2.89511273
135response to interferon-alpha (GO:0035455)2.89134967
136positive regulation of systemic arterial blood pressure (GO:0003084)2.87938155
137purine-containing compound salvage (GO:0043101)2.87926979
138negative regulation of T cell apoptotic process (GO:0070233)2.87674614
139dendritic cell migration (GO:0036336)2.87548021
140positive regulation of cellular amide metabolic process (GO:0034250)2.87045078
141translational initiation (GO:0006413)2.86780331
142regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86089981
143IMP metabolic process (GO:0046040)2.86074630
144embryonic hemopoiesis (GO:0035162)2.85858482
145nucleotide-excision repair, DNA gap filling (GO:0006297)2.85014193
146regulation of T-helper 1 cell differentiation (GO:0045625)2.83451615
147cellular response to interferon-beta (GO:0035458)2.82195321
148negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.82088800
149Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81317293
150CENP-A containing nucleosome assembly (GO:0034080)2.80751592
151negative regulation of heart contraction (GO:0045822)2.79020173
152protein complex disassembly (GO:0043241)2.78748983
153superoxide anion generation (GO:0042554)2.76991635
154regulation of leukocyte degranulation (GO:0043300)2.76907169
155hepatocyte apoptotic process (GO:0097284)2.75594023
156response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75201169
157response to host immune response (GO:0052572)2.75201169
158negative regulation of stress fiber assembly (GO:0051497)2.74718323
159histamine transport (GO:0051608)2.74538535
160positive regulation of isotype switching (GO:0045830)2.73395577
161telomere maintenance (GO:0000723)2.72758027
162regulation of hemostasis (GO:1900046)2.72595138
163regulation of blood coagulation (GO:0030193)2.72595138
164L-fucose catabolic process (GO:0042355)2.72081895
165fucose catabolic process (GO:0019317)2.72081895
166L-fucose metabolic process (GO:0042354)2.72081895
167fusion of sperm to egg plasma membrane (GO:0007342)2.70234976
168negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.70085439
169DNA ligation (GO:0006266)2.70024866
170nuclear-transcribed mRNA catabolic process (GO:0000956)2.69565782
171telomere organization (GO:0032200)2.69537057
172regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64786148
173IMP biosynthetic process (GO:0006188)2.64438676
174regulation of necroptotic process (GO:0060544)2.64197993
175positive regulation of T cell mediated cytotoxicity (GO:0001916)2.63503671
176regulation of B cell receptor signaling pathway (GO:0050855)2.62957965
177mRNA catabolic process (GO:0006402)2.62648325
178negative regulation of T-helper cell differentiation (GO:0045623)2.61278791
179negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.61278791
180pseudouridine synthesis (GO:0001522)2.61223947
181macromolecular complex disassembly (GO:0032984)2.60733422
182metallo-sulfur cluster assembly (GO:0031163)2.59081991
183iron-sulfur cluster assembly (GO:0016226)2.59081991
184cytokine production involved in immune response (GO:0002367)2.58905162
185regulation of T cell mediated cytotoxicity (GO:0001914)2.57819018
186aminoglycoside antibiotic metabolic process (GO:0030647)2.57191583
187positive regulation of macrophage differentiation (GO:0045651)2.57015132
188DNA unwinding involved in DNA replication (GO:0006268)2.56001774
189myeloid dendritic cell activation (GO:0001773)2.55578408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.12478099
2SCL_19346495_ChIP-Seq_HPC-7_Human4.48774362
3* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.07869099
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.59077916
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.34361993
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27993207
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22338756
8* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.12008704
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.02389127
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89508992
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.87349983
12* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.85933078
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.76905982
14TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.71676455
15GATA1_19941826_ChIP-Seq_K562_Human2.70322486
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69220828
17* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.68373997
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.61730387
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50398432
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44394406
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40985874
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.39711469
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30573264
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29916781
25* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.29352442
26* GATA2_19941826_ChIP-Seq_K562_Human2.28830866
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.28382826
28* SPI1_23547873_ChIP-Seq_NB4_Human2.24084952
29GATA1_22025678_ChIP-Seq_K562_Human2.22523582
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.18621220
31ERG_20887958_ChIP-Seq_HPC-7_Mouse2.14324779
32GATA2_21666600_ChIP-Seq_HMVEC_Human2.10817618
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.07107932
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.05053161
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01343235
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.99760152
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95695292
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95585377
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95301582
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94981339
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.94313077
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90001927
43FOXP3_21729870_ChIP-Seq_TREG_Human1.89118817
44VDR_23849224_ChIP-Seq_CD4+_Human1.88393407
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86748102
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83065061
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79155346
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77781444
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.77502526
50VDR_21846776_ChIP-Seq_THP-1_Human1.76380802
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73495256
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72286788
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72101699
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70898154
55* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69708038
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69383115
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.68765140
58GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.67813331
59* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.66929179
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.66487613
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65524909
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.62102528
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.58720247
64MYC_22102868_ChIP-Seq_BL_Human1.58446186
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58043852
66ELK4_26923725_Chip-Seq_MESODERM_Mouse1.56132565
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55713505
68VDR_24763502_ChIP-Seq_THP-1_Human1.51647822
69* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.50801580
70CIITA_25753668_ChIP-Seq_RAJI_Human1.50353456
71MYB_26560356_Chip-Seq_TH2_Human1.50217281
72XRN2_22483619_ChIP-Seq_HELA_Human1.50179990
73* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49648070
74ELK1_19687146_ChIP-ChIP_HELA_Human1.46854384
75* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46029085
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45300683
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44595626
78HTT_18923047_ChIP-ChIP_STHdh_Human1.44390329
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44139879
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42405137
81MYB_26560356_Chip-Seq_TH1_Human1.41128018
82* IRF8_27001747_Chip-Seq_BMDM_Mouse1.40063643
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36516992
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34622605
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34487225
86GATA3_27048872_Chip-Seq_THYMUS_Human1.34196874
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32453730
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31481147
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29177643
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.28964204
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28180890
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.26920272
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26241062
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24523078
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24420638
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23724265
97MAF_26560356_Chip-Seq_TH1_Human1.23171047
98* GATA1_19941827_ChIP-Seq_MEL_Mouse1.21748788
99* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21720168
100FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21142698
101GABP_19822575_ChIP-Seq_HepG2_Human1.21128600
102RUNX_20019798_ChIP-Seq_JUKART_Human1.20192629
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19661160
104GATA3_26560356_Chip-Seq_TH2_Human1.19578314
105VDR_24787735_ChIP-Seq_THP-1_Human1.17214437
106TTF2_22483619_ChIP-Seq_HELA_Human1.16974218
107KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.15612372
108GBX2_23144817_ChIP-Seq_PC3_Human1.13703808
109SALL4_22934838_ChIP-ChIP_CD34+_Human1.13445973
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12997327
111EZH2_22144423_ChIP-Seq_EOC_Human1.12581099
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11623083
113* UTX_26944678_Chip-Seq_JUKART_Human1.09151293
114* ETS1_22383799_ChIP-Seq_G1ME_Mouse1.09105924
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07943979
116TCF7_22412390_ChIP-Seq_EML_Mouse1.07483323
117THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07280923
118SPI1_23127762_ChIP-Seq_K562_Human1.03240940
119ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02508969
120DCP1A_22483619_ChIP-Seq_HELA_Human1.02299977
121NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02147443
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02147443
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01877553
124* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00946274
125NCOR1_26117541_ChIP-Seq_K562_Human0.98344442
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97126926
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97048235
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.96878114
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95352247
130SPI1_20517297_ChIP-Seq_HL60_Human0.94895875
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94070879
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93697489
133FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92601812
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92033253
135* PU_27001747_Chip-Seq_BMDM_Mouse0.89772224
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89411576
137CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88986750
138MYC_18940864_ChIP-ChIP_HL60_Human0.86508570
139YY1_21170310_ChIP-Seq_MESCs_Mouse0.86438202
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86078472
141* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84592591
142SMRT_27268052_Chip-Seq_Bcells_Human0.84352667
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.84003405
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82899170
145SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74707299
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74660999
147CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73760259
148LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.72674238
149STAT1_20625510_ChIP-Seq_HELA_Human0.71795724
150FLI1_27457419_Chip-Seq_LIVER_Mouse0.71739206
151GF1_26923725_Chip-Seq_HPCs_Mouse0.71506760
152RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71453033
153EGR1_23403033_ChIP-Seq_LIVER_Mouse0.69428569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.65624248
2MP0008004_abnormal_stomach_pH4.57039293
3MP0001835_abnormal_antigen_presentation3.57332912
4MP0004808_abnormal_hematopoietic_stem3.26271258
5MP0005464_abnormal_platelet_physiology3.18825044
6MP0005174_abnormal_tail_pigmentation3.14741793
7MP0003303_peritoneal_inflammation3.14171015
8MP0005075_abnormal_melanosome_morpholog2.89377184
9MP0000465_gastrointestinal_hemorrhage2.83356104
10MP0009785_altered_susceptibility_to2.76724778
11MP0001545_abnormal_hematopoietic_system2.66371678
12MP0005397_hematopoietic_system_phenotyp2.66371678
13MP0004147_increased_porphyrin_level2.52586391
14MP0005671_abnormal_response_to2.47194913
15MP0000685_abnormal_immune_system2.43574653
16MP0003763_abnormal_thymus_physiology2.30175468
17MP0002398_abnormal_bone_marrow2.25792687
18MP0005025_abnormal_response_to2.24458299
19MP0002148_abnormal_hypersensitivity_rea2.19983137
20MP0003724_increased_susceptibility_to2.19167208
21MP0000490_abnormal_crypts_of2.17670845
22MP0002095_abnormal_skin_pigmentation2.13462164
23MP0006054_spinal_hemorrhage2.12528217
24MP0003693_abnormal_embryo_hatching2.09719886
25MP0008057_abnormal_DNA_replication2.06835910
26MP0001853_heart_inflammation2.05788584
27MP0002166_altered_tumor_susceptibility2.05155483
28MP0001800_abnormal_humoral_immune2.04802938
29MP0003436_decreased_susceptibility_to2.01433431
30MP0010094_abnormal_chromosome_stability2.01174948
31MP0000689_abnormal_spleen_morphology2.00246638
32MP0002420_abnormal_adaptive_immunity1.99265525
33MP0001819_abnormal_immune_cell1.96851166
34MP0005000_abnormal_immune_tolerance1.96816918
35MP0002452_abnormal_antigen_presenting1.95967648
36MP0002723_abnormal_immune_serum1.95397281
37MP0002419_abnormal_innate_immunity1.90080805
38MP0002722_abnormal_immune_system1.87256824
39MP0004084_abnormal_cardiac_muscle1.87233873
40MP0008007_abnormal_cellular_replicative1.85135854
41MP0005083_abnormal_biliary_tract1.82717957
42MP0003566_abnormal_cell_adhesion1.81016472
43MP0000716_abnormal_immune_system1.80911638
44MP0002006_tumorigenesis1.77762941
45MP0001851_eye_inflammation1.75521069
46MP0002429_abnormal_blood_cell1.74630223
47MP0008058_abnormal_DNA_repair1.68490719
48MP0001873_stomach_inflammation1.65955546
49MP0003866_abnormal_defecation1.65713085
50MP0010155_abnormal_intestine_physiology1.65299419
51MP0006292_abnormal_olfactory_placode1.64616926
52MP0004130_abnormal_muscle_cell1.61347501
53MP0000230_abnormal_systemic_arterial1.55089698
54MP0003943_abnormal_hepatobiliary_system1.53480616
55MP0003300_gastrointestinal_ulcer1.50513125
56MP0005387_immune_system_phenotype1.49238424
57MP0001790_abnormal_immune_system1.49238424
58MP0005058_abnormal_lysosome_morphology1.48957445
59MP0009697_abnormal_copulation1.48833058
60MP0009379_abnormal_foot_pigmentation1.48254943
61MP0001986_abnormal_taste_sensitivity1.44395757
62MP0002405_respiratory_system_inflammati1.40786180
63MP0000703_abnormal_thymus_morphology1.39200575
64MP0003077_abnormal_cell_cycle1.39117672
65MP0000015_abnormal_ear_pigmentation1.37084957
66MP0005167_abnormal_blood-brain_barrier1.36332654
67MP0008775_abnormal_heart_ventricle1.32902787
68MP0004036_abnormal_muscle_relaxation1.31517072
69MP0009333_abnormal_splenocyte_physiolog1.31164462
70MP0000249_abnormal_blood_vessel1.31163126
71MP0005084_abnormal_gallbladder_morpholo1.28771384
72MP0001845_abnormal_inflammatory_respons1.27866573
73MP0004957_abnormal_blastocyst_morpholog1.27635212
74MP0009278_abnormal_bone_marrow1.22889168
75MP0005409_darkened_coat_color1.21581757
76MP0004883_abnormal_blood_vessel1.18340711
77MP0002736_abnormal_nociception_after1.18029801
78MP0008469_abnormal_protein_level1.16572660
79MP0002019_abnormal_tumor_incidence1.15365698
80MP0003111_abnormal_nucleus_morphology1.14792518
81MP0002998_abnormal_bone_remodeling1.10751550
82MP0008260_abnormal_autophagy1.09178597
83MP0001188_hyperpigmentation1.08519954
84MP0000343_altered_response_to1.06922438
85MP0000372_irregular_coat_pigmentation1.05965680
86MP0004484_altered_response_of1.03727540
87MP0002009_preneoplasia0.98968614
88MP0002132_abnormal_respiratory_system0.96904440
89MP0003172_abnormal_lysosome_physiology0.96456299
90MP0002075_abnormal_coat/hair_pigmentati0.95677748
91MP0003075_altered_response_to0.95359935
92MP0008872_abnormal_physiological_respon0.94830006
93MP0003656_abnormal_erythrocyte_physiolo0.94453929
94MP0001348_abnormal_lacrimal_gland0.94261779
95MP0009764_decreased_sensitivity_to0.94154102
96MP0005410_abnormal_fertilization0.93168534
97MP0003448_altered_tumor_morphology0.91769438
98MP0008874_decreased_physiological_sensi0.90969000
99MP0003786_premature_aging0.90629825
100MP0000313_abnormal_cell_death0.89762045
101MP0002877_abnormal_melanocyte_morpholog0.89243978
102MP0001879_abnormal_lymphatic_vessel0.88735925
103MP0005310_abnormal_salivary_gland0.87672702
104MP0003186_abnormal_redox_activity0.86925157
105MP0003879_abnormal_hair_cell0.86370926
106MP0006036_abnormal_mitochondrial_physio0.86070320
107MP0001764_abnormal_homeostasis0.85985401
108MP0010329_abnormal_lipoprotein_level0.85807035
109MP0006082_CNS_inflammation0.85546742
110MP0004381_abnormal_hair_follicle0.83117338
111MP0010307_abnormal_tumor_latency0.81002970
112MP0000681_abnormal_thyroid_gland0.80450062
113MP0000371_diluted_coat_color0.80258459
114MP0003567_abnormal_fetal_cardiomyocyte0.80243474
115MP0009642_abnormal_blood_homeostasis0.79759946
116MP0002733_abnormal_thermal_nociception0.75654660
117MP0009765_abnormal_xenobiotic_induced0.74210620
118MP0001765_abnormal_ion_homeostasis0.74071858
119MP0005164_abnormal_response_to0.73577582
120MP0005165_increased_susceptibility_to0.73476586
121MP0005381_digestive/alimentary_phenotyp0.71664287
122MP0000858_altered_metastatic_potential0.71635285
123MP0009763_increased_sensitivity_to0.70210094
124MP0001663_abnormal_digestive_system0.69761693
125MP0003091_abnormal_cell_migration0.69509019
126MP0001533_abnormal_skeleton_physiology0.69404130
127MP0005023_abnormal_wound_healing0.69233575
128MP0004947_skin_inflammation0.68698248
129MP0003638_abnormal_response/metabolism_0.68579207
130MP0003183_abnormal_peptide_metabolism0.67777252
131MP0003191_abnormal_cellular_cholesterol0.67591900
132MP0001544_abnormal_cardiovascular_syste0.65253960
133MP0005385_cardiovascular_system_phenoty0.65253960
134MP0005535_abnormal_body_temperature0.64887605
135MP0005166_decreased_susceptibility_to0.64455298
136MP0001968_abnormal_touch/_nociception0.64357050
137MP0005646_abnormal_pituitary_gland0.64005612
138MP0003828_pulmonary_edema0.62616996
139MP0001186_pigmentation_phenotype0.61460496
140MP0004510_myositis0.59847922
141MP0002938_white_spotting0.59782058
142MP0000598_abnormal_liver_morphology0.58491585
143MP0000477_abnormal_intestine_morphology0.56024278

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.35332799
2Prolonged bleeding time (HP:0003010)5.28816655
3Thrombocytosis (HP:0001894)5.24897103
4Aplastic anemia (HP:0001915)5.03844344
5Hyperlipoproteinemia (HP:0010980)4.47975508
6IgM deficiency (HP:0002850)4.41913031
7Abnormal number of erythroid precursors (HP:0012131)4.34172964
8Abnormality of cells of the erythroid lineage (HP:0012130)4.23624006
9Chronic otitis media (HP:0000389)4.08364482
10Purpura (HP:0000979)3.88254383
11Poikilocytosis (HP:0004447)3.86999304
12Epistaxis (HP:0000421)3.75169447
13Type 2 muscle fiber atrophy (HP:0003554)3.72268157
14Acanthocytosis (HP:0001927)3.67255421
15Reduced antithrombin III activity (HP:0001976)3.55589368
16Elevated erythrocyte sedimentation rate (HP:0003565)3.51923351
17Myositis (HP:0100614)3.47895255
18Muscle fiber atrophy (HP:0100295)3.47610763
19Eczematoid dermatitis (HP:0000976)3.45239473
20Stomatitis (HP:0010280)3.45009970
21Abnormality of the common coagulation pathway (HP:0010990)3.35670379
22Abnormal platelet function (HP:0011869)3.35125689
23Impaired platelet aggregation (HP:0003540)3.35125689
24Dyschromatopsia (HP:0007641)3.32708047
25Reticulocytopenia (HP:0001896)3.32271075
26Abnormality of the heme biosynthetic pathway (HP:0010472)3.31635893
27Recurrent abscess formation (HP:0002722)3.30028278
28Abnormal platelet volume (HP:0011876)3.29199332
29Conjunctival telangiectasia (HP:0000524)3.29150478
30Type I transferrin isoform profile (HP:0003642)3.27288443
31Gingival bleeding (HP:0000225)3.16466925
32Recurrent bacterial skin infections (HP:0005406)3.15666171
33Acute lymphatic leukemia (HP:0006721)3.08135396
34Abnormality of the vasculature of the conjunctiva (HP:0008054)3.06933320
35Myelodysplasia (HP:0002863)2.98800364
3611 pairs of ribs (HP:0000878)2.94882275
37Recurrent viral infections (HP:0004429)2.94650999
38Increased mean platelet volume (HP:0011877)2.92589414
39Acute myeloid leukemia (HP:0004808)2.92010248
40Menorrhagia (HP:0000132)2.87105111
41Abnormality of the prostate (HP:0008775)2.85198388
42Abnormality of T cell physiology (HP:0011840)2.81461565
43Obstructive lung disease (HP:0006536)2.80436451
44Chronic obstructive pulmonary disease (HP:0006510)2.80436451
45Albinism (HP:0001022)2.79342194
46Abnormal pupillary function (HP:0007686)2.78716308
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.76737791
48Abnormal protein N-linked glycosylation (HP:0012347)2.76737791
49Abnormal protein glycosylation (HP:0012346)2.76737791
50Abnormal glycosylation (HP:0012345)2.76737791
51Cellulitis (HP:0100658)2.70833509
52Increased density of long bones (HP:0006392)2.69507752
53Pancytopenia (HP:0001876)2.63323165
54Pallor (HP:0000980)2.60048838
55Joint swelling (HP:0001386)2.56752776
56Paralysis (HP:0003470)2.53295306
57Recurrent bronchitis (HP:0002837)2.48104343
58Amaurosis fugax (HP:0100576)2.46571281
59Hepatosplenomegaly (HP:0001433)2.44344829
60Increased IgM level (HP:0003496)2.44116685
61B lymphocytopenia (HP:0010976)2.41432947
62Abnormality of B cell number (HP:0010975)2.41432947
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.41169160
64Abnormality of the nasal mucosa (HP:0000433)2.40761822
65Panhypogammaglobulinemia (HP:0003139)2.40003664
66IgG deficiency (HP:0004315)2.37991653
67Joint hemorrhage (HP:0005261)2.36449989
68Nasal polyposis (HP:0100582)2.30975473
69Abnormality of lateral ventricle (HP:0030047)2.30263543
70Meningitis (HP:0001287)2.28695034
71Recurrent fungal infections (HP:0002841)2.25736773
72Tinnitus (HP:0000360)2.25232792
73Abnormality of iron homeostasis (HP:0011031)2.23912311
74Abnormality of macrophages (HP:0004311)2.22081063
75Nonprogressive disorder (HP:0003680)2.20991487
763-Methylglutaconic aciduria (HP:0003535)2.20744544
77Orchitis (HP:0100796)2.20631993
78Gonadotropin excess (HP:0000837)2.20439310
79Patchy hypopigmentation of hair (HP:0011365)2.20195711
80Episodic fever (HP:0001954)2.17230976
81Spontaneous hematomas (HP:0007420)2.15698097
82Encephalitis (HP:0002383)2.14665096
83Abnormality of T cells (HP:0002843)2.12431874
84Autoimmune hemolytic anemia (HP:0001890)2.11206924
85Weak cry (HP:0001612)2.07313941
86Papilledema (HP:0001085)2.06544206
87Macrocytic anemia (HP:0001972)2.05921247
88Papillary thyroid carcinoma (HP:0002895)2.05297875
89Recurrent skin infections (HP:0001581)2.03565337
90Neutropenia (HP:0001875)2.03355906
91T lymphocytopenia (HP:0005403)2.03134334
92Bruising susceptibility (HP:0000978)2.02909888
93Abnormal auditory evoked potentials (HP:0006958)2.02816045
94Spontaneous abortion (HP:0005268)2.01697528
95Lymphoma (HP:0002665)2.01668789
96Vertigo (HP:0002321)2.00748649
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00532526
98Agammaglobulinemia (HP:0004432)2.00142925
99Optic neuritis (HP:0100653)1.99908015
100Retrobulbar optic neuritis (HP:0100654)1.99908015
101Leukocytosis (HP:0001974)1.99267427
102Exertional dyspnea (HP:0002875)1.99145505
103Abnormality of the columella (HP:0009929)1.96502811
104Increased neuronal autofluorescent lipopigment (HP:0002074)1.95405016
105Vacuolated lymphocytes (HP:0001922)1.95211156
106Abnormality of T cell number (HP:0011839)1.93907319
107Oral leukoplakia (HP:0002745)1.92556486
108Abnormality of transition element cation homeostasis (HP:0011030)1.92265404
109Arterial thrombosis (HP:0004420)1.92229539
110Microcytic anemia (HP:0001935)1.90848324
111Xanthomatosis (HP:0000991)1.88722976
112Erythema (HP:0010783)1.86518417
113Bone marrow hypocellularity (HP:0005528)1.86503108
114Colon cancer (HP:0003003)1.85673409
115Recurrent gram-negative bacterial infections (HP:0005420)1.85311058
116Lymphopenia (HP:0001888)1.85284921
117Severe visual impairment (HP:0001141)1.84893973
118Inflammation of the large intestine (HP:0002037)1.84778179
119Increased serum ferritin (HP:0003281)1.84225047
120Vasculitis (HP:0002633)1.84188842
121Myocardial infarction (HP:0001658)1.84131893
122Thrombophlebitis (HP:0004418)1.83941894
123Pulmonary embolism (HP:0002204)1.83697926
124Hypoplasia of the thymus (HP:0000778)1.83570661
125Mediastinal lymphadenopathy (HP:0100721)1.82400535
126Decreased central vision (HP:0007663)1.82264553
127Abnormality of chromosome stability (HP:0003220)1.81753641
128Keratoconjunctivitis sicca (HP:0001097)1.79385955
129Polycythemia (HP:0001901)1.78732941
130Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78648422
131Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78648422
132White forelock (HP:0002211)1.78641694
133Hypoproteinemia (HP:0003075)1.78600367
134Generalized aminoaciduria (HP:0002909)1.77320161
135Gastrointestinal infarctions (HP:0005244)1.76976247
136Asplenia (HP:0001746)1.76300265
137Chest pain (HP:0100749)1.75463533
138Birth length less than 3rd percentile (HP:0003561)1.75283708
139Hypothermia (HP:0002045)1.74877238
140Abnormality of cells of the lymphoid lineage (HP:0012140)1.74541458
141Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73599753
142Basal ganglia calcification (HP:0002135)1.71998011
143Clubbing of toes (HP:0100760)1.71039333
144Ventricular fibrillation (HP:0001663)1.70604880
145Upper limb muscle weakness (HP:0003484)1.70251968
146Gastrointestinal inflammation (HP:0004386)1.67375400
147Granulocytopenia (HP:0001913)1.62971129
148Testicular neoplasm (HP:0010788)1.62787138
149Eosinophilia (HP:0001880)1.59329265
150Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.59324278
151Transitional cell carcinoma of the bladder (HP:0006740)1.57899199
152Muscle fibrillation (HP:0010546)1.57410038
153Gingivitis (HP:0000230)1.56745353
154Urticaria (HP:0001025)1.56305280
155Hyperthyroidism (HP:0000836)1.54208329
156Cerebral ischemia (HP:0002637)1.52683699
157Dysostosis multiplex (HP:0000943)1.52551386
158Uterine leiomyosarcoma (HP:0002891)1.50673439
159Leiomyosarcoma (HP:0100243)1.50673439
160Diplopia (HP:0000651)1.49867834
161Abnormality of binocular vision (HP:0011514)1.49867834
162Mucosal telangiectasiae (HP:0100579)1.49802413
163Keratoconjunctivitis (HP:0001096)1.49508604
164Arthralgia (HP:0002829)1.48466252
165Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.48310149
166Nausea (HP:0002018)1.48145181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.19712583
2KIT3.79173331
3MST43.64383650
4BMX3.26579968
5STK163.04523447
6MAP4K12.77960724
7FLT32.57829260
8TEC2.57628925
9MUSK2.50819997
10MAP3K122.46621568
11BTK2.40005697
12NME22.26581745
13PTK2B2.20972609
14GRK62.19983214
15IRAK42.18727004
16WEE12.17626046
17BMPR22.17410230
18EIF2AK12.09458948
19TXK2.03684941
20TGFBR12.02895262
21MATK2.01772585
22MKNK11.97102655
23TNIK1.97066932
24FGR1.95681200
25CCNB11.90705333
26ACVR1B1.89824351
27CSF1R1.80225062
28EEF2K1.67291763
29GRK51.64811736
30CDK191.63366365
31CSK1.62919678
32PIM21.59768730
33CDK81.56276586
34VRK11.55860665
35MAP2K31.54696995
36TAOK31.49424914
37STK31.49316880
38RPS6KB21.46631772
39CDC71.43153564
40SYK1.43018620
41EIF2AK31.41829311
42IKBKE1.40737893
43TIE11.39212901
44ZAP701.36753975
45MAPKAPK51.33984585
46TGFBR21.31999729
47MAPKAPK31.28213835
48IRAK11.26143020
49BRSK21.23586254
50TBK11.20602803
51JAK31.16126177
52PIM11.15443393
53BLK1.13617127
54PASK1.12285534
55CLK11.11454833
56NEK91.10392206
57STK241.09597941
58MKNK21.08129807
59PDK11.07888725
60LYN1.07342955
61BCKDK1.05770706
62BUB11.02581799
63MYLK1.01360089
64DAPK10.99469983
65ATR0.98546149
66CDK70.97617734
67FES0.97517166
68YES10.94935352
69IKBKB0.94771854
70JAK20.93936355
71JAK10.92895057
72PRKG20.92798737
73MAP3K50.92617283
74EPHA30.91401782
75SRPK10.91351127
76EPHB10.89300068
77ADRBK20.88440423
78DYRK30.87466402
79MARK30.87318241
80TNK20.86914601
81PDPK10.86542687
82TYK20.85280207
83PIK3CG0.84475452
84MAP3K30.83935681
85PAK10.83887779
86CAMKK20.80872027
87MAP2K60.80318352
88LCK0.77675833
89RET0.77359701
90TAOK10.74409237
91IRAK20.74139569
92PLK20.72158364
93PAK40.69630113
94TSSK60.69446831
95PLK40.68578703
96KDR0.67489747
97RPS6KA60.64919181
98ADRBK10.64157506
99EIF2AK20.63066996
100ERBB20.62781641
101MAP3K10.60741703
102PRKD10.59461437
103CHUK0.59461318
104FYN0.58928106
105STK40.58348124
106SGK20.58336941
107MAPK120.57223626
108IRAK30.56898132
109MAPK40.56306981
110AURKB0.55758891
111TESK20.55484008
112TAOK20.55252593
113MAP3K60.55128647
114RPS6KA50.55117665
115PNCK0.53855038
116SGK30.53428530
117DAPK20.53087177
118ITK0.52998860
119NLK0.52637524
120HCK0.52416338
121LRRK20.52097294
122NEK20.51946107
123FER0.51825875
124PDGFRB0.51703183
125MAP3K140.50902434
126DAPK30.50676132
127RPS6KA40.48960153
128TRPM70.47953613
129PKN20.47625131
130LMTK20.45206489
131RPS6KL10.45059417
132RPS6KC10.45059417
133MAP3K110.43988829
134PRKCQ0.43457005
135RPS6KB10.43421429
136PRKACG0.43244133
137TRIM280.42828287
138MAP3K20.41947597
139ZAK0.41882661
140MAP2K10.40331975
141CDK40.39311091
142PRKCD0.36512005
143HIPK20.36483812
144PINK10.36365110
145PLK10.36355018
146CAMK10.36325542
147PRKG10.35759100
148BRSK10.35410325
149ILK0.34700814
150SIK30.32798678
151CSNK2A10.31615227
152DYRK1B0.29773327
153PAK30.27209717
154FGFR30.26743316
155STK100.25328984
156IGF1R0.24598918
157RAF10.24352603

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.97521603
2Ribosome_Homo sapiens_hsa030104.12545173
3Mismatch repair_Homo sapiens_hsa034303.69636168
4Base excision repair_Homo sapiens_hsa034102.99661924
5Homologous recombination_Homo sapiens_hsa034402.94077754
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.35056320
7Pyrimidine metabolism_Homo sapiens_hsa002402.29221640
8RNA polymerase_Homo sapiens_hsa030202.21643913
9Nucleotide excision repair_Homo sapiens_hsa034202.17396685
10Spliceosome_Homo sapiens_hsa030402.02049694
11Non-homologous end-joining_Homo sapiens_hsa034501.96071609
12Hematopoietic cell lineage_Homo sapiens_hsa046401.82313703
13Primary immunodeficiency_Homo sapiens_hsa053401.74933417
14Staphylococcus aureus infection_Homo sapiens_hsa051501.70622798
15RNA degradation_Homo sapiens_hsa030181.70427396
16Cell cycle_Homo sapiens_hsa041101.59723822
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58191622
18Leishmaniasis_Homo sapiens_hsa051401.52967671
19T cell receptor signaling pathway_Homo sapiens_hsa046601.50512862
20Caffeine metabolism_Homo sapiens_hsa002321.50308062
21Platelet activation_Homo sapiens_hsa046111.48794631
22Measles_Homo sapiens_hsa051621.48400851
23Herpes simplex infection_Homo sapiens_hsa051681.47837833
24Fanconi anemia pathway_Homo sapiens_hsa034601.47225285
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46505728
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.44222867
27ECM-receptor interaction_Homo sapiens_hsa045121.41031311
28Gap junction_Homo sapiens_hsa045401.40979660
29B cell receptor signaling pathway_Homo sapiens_hsa046621.37558830
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36736076
31Nitrogen metabolism_Homo sapiens_hsa009101.36393008
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35884767
33Purine metabolism_Homo sapiens_hsa002301.35116097
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34399903
35Asthma_Homo sapiens_hsa053101.33449471
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.32707696
37Folate biosynthesis_Homo sapiens_hsa007901.31338429
38Proteasome_Homo sapiens_hsa030501.30998256
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30976585
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30964379
41Graft-versus-host disease_Homo sapiens_hsa053321.30687343
42Phagosome_Homo sapiens_hsa041451.30226582
43Other glycan degradation_Homo sapiens_hsa005111.28988644
44Protein export_Homo sapiens_hsa030601.26333269
45Antigen processing and presentation_Homo sapiens_hsa046121.25615775
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.24569700
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23472159
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.21667965
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.18918898
50Endocytosis_Homo sapiens_hsa041441.18293930
51p53 signaling pathway_Homo sapiens_hsa041151.17696607
52N-Glycan biosynthesis_Homo sapiens_hsa005101.15797858
53Serotonergic synapse_Homo sapiens_hsa047261.12111380
54RNA transport_Homo sapiens_hsa030131.11361239
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11341060
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.10992168
57Allograft rejection_Homo sapiens_hsa053301.10471489
58Basal transcription factors_Homo sapiens_hsa030221.09557200
59Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09210207
60Autoimmune thyroid disease_Homo sapiens_hsa053201.08779235
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08578922
62Legionellosis_Homo sapiens_hsa051341.06483902
63Collecting duct acid secretion_Homo sapiens_hsa049660.99169987
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98151304
65Pancreatic cancer_Homo sapiens_hsa052120.97907891
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97726759
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96102886
68Pancreatic secretion_Homo sapiens_hsa049720.95061287
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94796303
70Acute myeloid leukemia_Homo sapiens_hsa052210.91054878
71Alcoholism_Homo sapiens_hsa050340.90382260
72Long-term depression_Homo sapiens_hsa047300.88416410
73One carbon pool by folate_Homo sapiens_hsa006700.87609773
74Choline metabolism in cancer_Homo sapiens_hsa052310.83920609
75Pertussis_Homo sapiens_hsa051330.82786246
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81967646
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80939153
78Shigellosis_Homo sapiens_hsa051310.80658393
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80127504
80Rap1 signaling pathway_Homo sapiens_hsa040150.80111177
81Influenza A_Homo sapiens_hsa051640.79476910
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76102394
83Glycerolipid metabolism_Homo sapiens_hsa005610.74853534
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73796040
85Hepatitis B_Homo sapiens_hsa051610.73458880
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.73296271
87Viral myocarditis_Homo sapiens_hsa054160.72916340
88Osteoclast differentiation_Homo sapiens_hsa043800.71749609
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71705161
90Systemic lupus erythematosus_Homo sapiens_hsa053220.71523717
91Endometrial cancer_Homo sapiens_hsa052130.70826698
92Renal cell carcinoma_Homo sapiens_hsa052110.70164782
93VEGF signaling pathway_Homo sapiens_hsa043700.69285994
94Pentose phosphate pathway_Homo sapiens_hsa000300.68819266
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68338757
96Rheumatoid arthritis_Homo sapiens_hsa053230.68104444
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67643352
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67347483
99Focal adhesion_Homo sapiens_hsa045100.67266827
100Malaria_Homo sapiens_hsa051440.67035504
101Amoebiasis_Homo sapiens_hsa051460.66583524
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65907694
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65115139
104Sulfur relay system_Homo sapiens_hsa041220.64825331
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64754028
106Apoptosis_Homo sapiens_hsa042100.64239969
107Epstein-Barr virus infection_Homo sapiens_hsa051690.63147514
108Type I diabetes mellitus_Homo sapiens_hsa049400.62179174
109Thyroid cancer_Homo sapiens_hsa052160.62161677
110Olfactory transduction_Homo sapiens_hsa047400.62145767
111Arachidonic acid metabolism_Homo sapiens_hsa005900.57415940
112Toxoplasmosis_Homo sapiens_hsa051450.57040697
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.56753652
114Ras signaling pathway_Homo sapiens_hsa040140.56195444
115Galactose metabolism_Homo sapiens_hsa000520.55500597
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54819474
117Glioma_Homo sapiens_hsa052140.53617094
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.53560003
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52888121
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50789879
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.50410474
122Morphine addiction_Homo sapiens_hsa050320.50406177
123Circadian entrainment_Homo sapiens_hsa047130.50346328
124Viral carcinogenesis_Homo sapiens_hsa052030.49938150
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.49598192
126Renin-angiotensin system_Homo sapiens_hsa046140.49464011
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.47199424
128Cholinergic synapse_Homo sapiens_hsa047250.45136673
129Renin secretion_Homo sapiens_hsa049240.44210671
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44162974
131Non-small cell lung cancer_Homo sapiens_hsa052230.44128627
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43263456
133Linoleic acid metabolism_Homo sapiens_hsa005910.43043473
134ABC transporters_Homo sapiens_hsa020100.41945256
135Regulation of autophagy_Homo sapiens_hsa041400.41406413
136FoxO signaling pathway_Homo sapiens_hsa040680.41166559
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41019439
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.39892270
139Salmonella infection_Homo sapiens_hsa051320.38295085
140mRNA surveillance pathway_Homo sapiens_hsa030150.37332143
141Tuberculosis_Homo sapiens_hsa051520.36287775
142Chronic myeloid leukemia_Homo sapiens_hsa052200.35243138
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34915303
144TNF signaling pathway_Homo sapiens_hsa046680.34531738
145Small cell lung cancer_Homo sapiens_hsa052220.34369698
146Selenocompound metabolism_Homo sapiens_hsa004500.33467007
147African trypanosomiasis_Homo sapiens_hsa051430.31917276
148Chemokine signaling pathway_Homo sapiens_hsa040620.29744899
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29183300
150HTLV-I infection_Homo sapiens_hsa051660.27715163
151Cyanoamino acid metabolism_Homo sapiens_hsa004600.24190575
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.23146843
153Hepatitis C_Homo sapiens_hsa051600.22316438
154Sphingolipid metabolism_Homo sapiens_hsa006000.19684382

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