RGS16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.89628677
2L-phenylalanine catabolic process (GO:0006559)6.89628677
3negative regulation of fibrinolysis (GO:0051918)6.72061709
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.66584714
5L-phenylalanine metabolic process (GO:0006558)6.66584714
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.04081555
7regulation of fibrinolysis (GO:0051917)5.97982627
8aromatic amino acid family catabolic process (GO:0009074)5.92277276
9behavioral response to nicotine (GO:0035095)5.66705782
10alpha-linolenic acid metabolic process (GO:0036109)5.46626313
11high-density lipoprotein particle remodeling (GO:0034375)5.38445304
12peptidyl-glutamic acid carboxylation (GO:0017187)5.24396405
13protein carboxylation (GO:0018214)5.24396405
14kynurenine metabolic process (GO:0070189)5.15569061
15bile acid biosynthetic process (GO:0006699)5.08625371
16tryptophan catabolic process (GO:0006569)5.01108868
17indole-containing compound catabolic process (GO:0042436)5.01108868
18indolalkylamine catabolic process (GO:0046218)5.01108868
19negative regulation of cholesterol transport (GO:0032375)4.94397809
20negative regulation of sterol transport (GO:0032372)4.94397809
21urea metabolic process (GO:0019627)4.91560297
22urea cycle (GO:0000050)4.91560297
23regulation of immunoglobulin secretion (GO:0051023)4.79472682
24reverse cholesterol transport (GO:0043691)4.74197688
25tryptophan metabolic process (GO:0006568)4.74093921
26glyoxylate metabolic process (GO:0046487)4.69918807
27regulation of cholesterol esterification (GO:0010872)4.58604460
28regulation of protein activation cascade (GO:2000257)4.51745682
29bile acid metabolic process (GO:0008206)4.49291634
30regulation of vitamin D biosynthetic process (GO:0060556)4.45064621
31nitrogen cycle metabolic process (GO:0071941)4.44323870
32protein-lipid complex remodeling (GO:0034368)4.41662263
33macromolecular complex remodeling (GO:0034367)4.41662263
34plasma lipoprotein particle remodeling (GO:0034369)4.41662263
35sulfur amino acid catabolic process (GO:0000098)4.40796987
36triglyceride homeostasis (GO:0070328)4.38890739
37acylglycerol homeostasis (GO:0055090)4.38890739
38tyrosine metabolic process (GO:0006570)4.36447191
39regulation of chronic inflammatory response (GO:0002676)4.33410122
40cysteine metabolic process (GO:0006534)4.32978283
41phospholipid efflux (GO:0033700)4.32899936
42branching involved in labyrinthine layer morphogenesis (GO:0060670)4.32657301
43plasma lipoprotein particle clearance (GO:0034381)4.32327190
44serine family amino acid catabolic process (GO:0009071)4.29670349
45complement activation, alternative pathway (GO:0006957)4.28313511
46regulation of plasminogen activation (GO:0010755)4.27591420
47regulation of cholesterol homeostasis (GO:2000188)4.24187790
48aromatic amino acid family metabolic process (GO:0009072)4.23079117
49fibrinolysis (GO:0042730)4.22659857
50regulation of triglyceride catabolic process (GO:0010896)4.18762401
51DNA deamination (GO:0045006)4.18696805
52regulation of complement activation (GO:0030449)4.15063504
53lysine catabolic process (GO:0006554)4.12559474
54lysine metabolic process (GO:0006553)4.12559474
55regulation of regulatory T cell differentiation (GO:0045589)4.11307892
56regulation of isotype switching to IgG isotypes (GO:0048302)4.03951150
57amino-acid betaine metabolic process (GO:0006577)4.00200672
58cholesterol efflux (GO:0033344)3.99804623
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97984938
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.97984938
61NADH dehydrogenase complex assembly (GO:0010257)3.97984938
62alpha-amino acid catabolic process (GO:1901606)3.96316605
63cellular ketone body metabolic process (GO:0046950)3.95447394
64endoderm formation (GO:0001706)3.92670628
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.91666760
66bile acid and bile salt transport (GO:0015721)3.89536715
67homocysteine metabolic process (GO:0050667)3.83668528
68cellular glucuronidation (GO:0052695)3.81343574
69glutamate metabolic process (GO:0006536)3.76872237
70glycine metabolic process (GO:0006544)3.75919277
71plasma lipoprotein particle assembly (GO:0034377)3.74516338
72coenzyme catabolic process (GO:0009109)3.71508411
73dicarboxylic acid biosynthetic process (GO:0043650)3.70377361
74protein complex biogenesis (GO:0070271)3.66242695
75positive regulation of fatty acid beta-oxidation (GO:0032000)3.66012419
76positive regulation of defense response to virus by host (GO:0002230)3.65971330
77imidazole-containing compound metabolic process (GO:0052803)3.63146244
78positive regulation of fatty acid biosynthetic process (GO:0045723)3.61604459
79negative regulation of lipase activity (GO:0060192)3.61245439
80protein-lipid complex assembly (GO:0065005)3.60409278
81regulation of bile acid biosynthetic process (GO:0070857)3.59271532
82positive regulation of lipid catabolic process (GO:0050996)3.57878318
83cellular amino acid catabolic process (GO:0009063)3.57212264
84drug catabolic process (GO:0042737)3.55501997
85positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.54180892
86sulfation (GO:0051923)3.52841248
87cellular modified amino acid catabolic process (GO:0042219)3.52699814
88CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.50958801
89positive regulation of glomerulus development (GO:0090193)3.47683147
90benzene-containing compound metabolic process (GO:0042537)3.47339934
91arginine metabolic process (GO:0006525)3.47296528
92serine family amino acid metabolic process (GO:0009069)3.47239109
93lipoprotein metabolic process (GO:0042157)3.46320366
94low-density lipoprotein particle remodeling (GO:0034374)3.46182659
95serine family amino acid biosynthetic process (GO:0009070)3.45850136
96indolalkylamine metabolic process (GO:0006586)3.45374480
97negative regulation of systemic arterial blood pressure (GO:0003085)3.42764377
98cholesterol homeostasis (GO:0042632)3.41990703
99intestinal cholesterol absorption (GO:0030299)3.41595489
100phospholipid homeostasis (GO:0055091)3.39828790
101positive regulation of lipoprotein lipase activity (GO:0051006)3.39435051
102positive regulation of triglyceride lipase activity (GO:0061365)3.39435051
103sterol homeostasis (GO:0055092)3.39200451
104interferon-gamma production (GO:0032609)3.38856869
105ketone body metabolic process (GO:1902224)3.36774022
106plasma lipoprotein particle organization (GO:0071827)3.32176850
107regulation of glomerulus development (GO:0090192)3.31634306
108response to lipoprotein particle (GO:0055094)3.30991159
109aldehyde catabolic process (GO:0046185)3.29289440
110uronic acid metabolic process (GO:0006063)3.28873546
111glucuronate metabolic process (GO:0019585)3.28873546
112cellular biogenic amine catabolic process (GO:0042402)3.27981838
113amine catabolic process (GO:0009310)3.27981838
114regulation of fatty acid beta-oxidation (GO:0031998)3.27536313
115protein-lipid complex subunit organization (GO:0071825)3.26717233
116positive regulation of hemostasis (GO:1900048)3.26516928
117positive regulation of blood coagulation (GO:0030194)3.26516928
118acute-phase response (GO:0006953)3.25484392
119regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24380014
120interferon-gamma secretion (GO:0072643)3.22860090
121cellular response to ATP (GO:0071318)3.22563977
122mitochondrial respiratory chain complex assembly (GO:0033108)3.22281501
123very-low-density lipoprotein particle assembly (GO:0034379)3.22104838
124negative regulation of lipid transport (GO:0032369)3.21901192
125blood coagulation, intrinsic pathway (GO:0007597)3.21196768
126drug metabolic process (GO:0017144)3.20632304
127synaptic transmission, cholinergic (GO:0007271)3.17892064
128dentate gyrus development (GO:0021542)3.17836354
129positive regulation of cAMP-mediated signaling (GO:0043950)3.16549686
130cellular response to nicotine (GO:0071316)3.13231289
131somite development (GO:0061053)3.09470392
132regulation of vitamin metabolic process (GO:0030656)3.07189384
133negative regulation of telomerase activity (GO:0051974)3.06541274
134positive regulation of isotype switching (GO:0045830)3.03026001
135epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.02578348
136membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98555342
137positive regulation of heat generation (GO:0031652)2.98544024
138regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.93396297
139platelet dense granule organization (GO:0060155)2.93264905
140water-soluble vitamin biosynthetic process (GO:0042364)2.88439963
141positive regulation of interleukin-17 production (GO:0032740)2.86265426
142positive regulation of DNA recombination (GO:0045911)2.84302667
143regulation of germinal center formation (GO:0002634)2.84105663
144positive regulation of oligodendrocyte differentiation (GO:0048714)2.82840705
145regulation of interleukin-12 biosynthetic process (GO:0045075)2.81286541
146eosinophil chemotaxis (GO:0048245)2.80473144
147regulation of fever generation (GO:0031620)2.72372271
148negative regulation of interleukin-10 production (GO:0032693)2.71245679
149cell proliferation in forebrain (GO:0021846)2.70940252
150activation of MAPKKK activity (GO:0000185)2.68103808
151positive regulation of lymphocyte apoptotic process (GO:0070230)2.67459949
152negative regulation of amino acid transport (GO:0051956)2.66495564
153regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.65575695
154negative regulation of acute inflammatory response (GO:0002674)2.62153968
155negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61031430
156positive regulation of prostaglandin secretion (GO:0032308)2.59764177
157germinal center formation (GO:0002467)2.58191924
158regulation of telomerase activity (GO:0051972)2.54429231
159establishment of protein localization to mitochondrial membrane (GO:0090151)2.53633309
160prostate gland growth (GO:0060736)2.53448497
161positive regulation of immunoglobulin production (GO:0002639)2.53223211
162cellular response to exogenous dsRNA (GO:0071360)2.53031549
163regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.52255344
164positive regulation of fatty acid transport (GO:2000193)2.50444163
165tolerance induction (GO:0002507)2.50347294
166positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.48062252
167protein polyglutamylation (GO:0018095)2.48001214
168positive regulation of B cell mediated immunity (GO:0002714)2.47952760
169positive regulation of immunoglobulin mediated immune response (GO:0002891)2.47952760
170positive regulation of activated T cell proliferation (GO:0042104)2.47559564
171peristalsis (GO:0030432)2.45608888
172regulation of cell proliferation involved in kidney development (GO:1901722)2.45421550
173eosinophil migration (GO:0072677)2.44887741
174regulation of lymphocyte chemotaxis (GO:1901623)2.42392346
175negative regulation of lipid storage (GO:0010888)2.41564074
176regulation of heat generation (GO:0031650)2.39317157
177positive regulation of chemokine biosynthetic process (GO:0045080)2.36517137
178myeloid dendritic cell differentiation (GO:0043011)2.36002709
179positive regulation of B cell proliferation (GO:0030890)2.35885899
180positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.35613375
181regulation of T-helper 1 cell differentiation (GO:0045625)2.34307547
182negative regulation of T cell differentiation (GO:0045581)2.33698890
183positive regulation of T cell apoptotic process (GO:0070234)2.32823667
184negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.32497803
185ATP synthesis coupled proton transport (GO:0015986)2.31845171
186energy coupled proton transport, down electrochemical gradient (GO:0015985)2.31845171
187regulation of T-helper cell differentiation (GO:0045622)2.31463143
188T cell lineage commitment (GO:0002360)2.31229679
189mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.30387892
190regulation of defense response to virus by host (GO:0050691)2.29413005
191positive regulation of metanephros development (GO:0072216)2.29322191
192negative regulation of mast cell activation (GO:0033004)2.29255932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.52485010
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.44282551
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.82868200
4EZH2_22144423_ChIP-Seq_EOC_Human5.23365848
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.19366194
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.57283424
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.18923709
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.14725241
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.79122454
10NOTCH1_21737748_ChIP-Seq_TLL_Human3.53571089
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.06965547
12CLOCK_20551151_ChIP-Seq_293T_Human2.99097565
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.63995143
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50799288
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.48960906
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.47839622
17* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.46365104
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42485220
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36746924
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.34187159
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33014209
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.22834183
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.21011748
24VDR_22108803_ChIP-Seq_LS180_Human2.19353201
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16939702
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10381369
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09251281
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03287505
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2624097
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.99267088
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.98407419
32ZNF274_21170338_ChIP-Seq_K562_Hela1.96864035
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95601210
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95522988
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90803080
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90298704
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88728951
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.84809992
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.81026510
40RNF2_27304074_Chip-Seq_NSC_Mouse1.80266301
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78607616
42IRF1_19129219_ChIP-ChIP_H3396_Human1.78037192
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77306146
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.77163586
45GBX2_23144817_ChIP-Seq_PC3_Human1.77061303
46* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76953516
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75143140
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74543814
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74530132
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.73923728
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69946949
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.69815373
53EWS_26573619_Chip-Seq_HEK293_Human1.67654199
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66673651
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66673651
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66539616
57MYC_18940864_ChIP-ChIP_HL60_Human1.65167101
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62902229
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.58990142
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58966496
61TAF15_26573619_Chip-Seq_HEK293_Human1.55422998
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.54739835
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54688758
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53117706
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52681365
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52001945
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50144230
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43040823
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42810586
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42161740
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39286212
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38682585
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37773457
74P300_19829295_ChIP-Seq_ESCs_Human1.34947048
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32024298
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27509081
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27221315
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24818681
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23933762
80REST_21632747_ChIP-Seq_MESCs_Mouse1.22686960
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22347709
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22347709
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.21746586
84FUS_26573619_Chip-Seq_HEK293_Human1.21396652
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20616430
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18374010
87BCAT_22108803_ChIP-Seq_LS180_Human1.17558586
88HNF4A_19822575_ChIP-Seq_HepG2_Human1.17319514
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.17061415
90MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15223408
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13866562
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11860806
93LXR_22292898_ChIP-Seq_THP-1_Human1.10733230
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10688201
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10009639
96* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09859501
97FOXO3_23340844_ChIP-Seq_DLD1_Human1.09803651
98* NFE2_27457419_Chip-Seq_LIVER_Mouse1.09231701
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.07802334
100* RUNX_20019798_ChIP-Seq_JUKART_Human1.06132480
101* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04857753
102ER_23166858_ChIP-Seq_MCF-7_Human1.04441776
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.02400289
104TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00105375
105REST_18959480_ChIP-ChIP_MESCs_Mouse0.99647824
106PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98291347
107PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97124740
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96941362
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96879917
110* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94550539
111* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94148596
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93827390
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93453543
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91688324
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91440049
116* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91368375
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91363301
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91017715
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90468802
120HTT_18923047_ChIP-ChIP_STHdh_Human0.90288428
121SMRT_27268052_Chip-Seq_Bcells_Human0.89323413
122NANOG_19829295_ChIP-Seq_ESCs_Human0.89321755
123SOX2_19829295_ChIP-Seq_ESCs_Human0.89321755
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89108080
125TAF2_19829295_ChIP-Seq_ESCs_Human0.89017163
126FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88674335
127FOXA1_25329375_ChIP-Seq_VCAP_Human0.88674335
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87202247
129AR_25329375_ChIP-Seq_VCAP_Human0.87170039
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.86432131
131ATF3_27146783_Chip-Seq_COLON_Human0.86293217
132VDR_23849224_ChIP-Seq_CD4+_Human0.85886942
133GATA3_21878914_ChIP-Seq_MCF-7_Human0.85744331
134STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85727836
135* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85719882
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85525372
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85328053
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84704034
139* RACK7_27058665_Chip-Seq_MCF-7_Human0.84086081
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.83474302
141RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83363270
142CJUN_26792858_Chip-Seq_BT549_Human0.81401624
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81259751
144NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81259751
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80894873
146GATA4_25053715_ChIP-Seq_YYC3_Human0.78183702
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76356219
148FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75846565
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75519432
150GATA1_22025678_ChIP-Seq_K562_Human0.74720889
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74562865
152ZNF263_19887448_ChIP-Seq_K562_Human0.73731729
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73430282
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73380802
155* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71344932
156TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.71254826
157* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69876902
158SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.68476143
159SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.68476143
160EGR1_19374776_ChIP-ChIP_THP-1_Human0.68365251
161SOX2_20726797_ChIP-Seq_SW620_Human0.68207976
162* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66017595
163TBX20_22080862_ChIP-Seq_HEART_Mouse0.64115972
164TBX20_22328084_ChIP-Seq_HEART_Mouse0.64115972
165SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63621784
166RARA_24833708_ChIP-Seq_LIVER_Mouse0.61993393
167JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61951956
168EGR1_19032775_ChIP-ChIP_M12_Human0.61251925
169ESR1_21235772_ChIP-Seq_MCF-7_Human0.61105891
170GATA1_19941826_ChIP-Seq_K562_Human0.60521964
171KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.60361045
172NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.59178266
173GATA2_21666600_ChIP-Seq_HMVEC_Human0.59056871
174GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.58770849
175FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58238046
176FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58040099
177Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.57923724
178CREB1_26743006_Chip-Seq_LNCaP_Human0.57595973
179GATA6_25053715_ChIP-Seq_YYC3_Human0.56455141
180BRD4_25478319_ChIP-Seq_HGPS_Human0.56406915
181PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.56197239
182* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.56141235
183JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55510451
184NFIB_24661679_ChIP-Seq_LUNG_Mouse0.55269162
185* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.54893488
186SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.54396989
187AUTS2_25519132_ChIP-Seq_293T-REX_Human0.54151750
188* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.53968994
189* GATA3_24758297_ChIP-Seq_MCF-7_Human0.53635857
190STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.53532991
191RARB_24833708_ChIP-Seq_LIVER_Mouse0.53106854
192FOXA1_25552417_ChIP-Seq_VCAP_Human0.53094782
193CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.52665709
194UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.52446407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.69394747
2MP0005360_urolithiasis6.76209457
3MP0005085_abnormal_gallbladder_physiolo5.55701109
4MP0005365_abnormal_bile_salt5.50971592
5MP0008875_abnormal_xenobiotic_pharmacok4.65520596
6MP0003252_abnormal_bile_duct3.60322083
7MP0003806_abnormal_nucleotide_metabolis3.43127229
8MP0005671_abnormal_response_to3.38970896
9MP0009840_abnormal_foam_cell3.28953811
10MP0010329_abnormal_lipoprotein_level3.12063991
11MP0005423_abnormal_somatic_nervous2.88050763
12MP0002653_abnormal_ependyma_morphology2.83850383
13MP0005083_abnormal_biliary_tract2.78938820
14MP0003195_calcinosis2.72251814
15MP0003724_increased_susceptibility_to2.47206807
16MP0002837_dystrophic_cardiac_calcinosis2.42737757
17MP0005332_abnormal_amino_acid2.29386831
18MP0001666_abnormal_nutrient_absorption2.23250612
19MP0003880_abnormal_central_pattern2.21646048
20MP0003705_abnormal_hypodermis_morpholog2.21229696
21MP0006292_abnormal_olfactory_placode2.18821720
22MP0001790_abnormal_immune_system2.17377670
23MP0005387_immune_system_phenotype2.17377670
24MP0002148_abnormal_hypersensitivity_rea2.16254145
25MP0000609_abnormal_liver_physiology2.14761895
26MP0002638_abnormal_pupillary_reflex2.11771509
27MP0006072_abnormal_retinal_apoptosis2.08311208
28MP0005646_abnormal_pituitary_gland2.07112287
29MP0002163_abnormal_gland_morphology2.03596805
30MP0005000_abnormal_immune_tolerance1.99539384
31MP0003646_muscle_fatigue1.95016945
32MP0003868_abnormal_feces_composition1.94608124
33MP0004742_abnormal_vestibular_system1.93112952
34MP0002118_abnormal_lipid_homeostasis1.86985238
35MP0002138_abnormal_hepatobiliary_system1.82487959
36MP0001485_abnormal_pinna_reflex1.80409663
37MP0009785_altered_susceptibility_to1.79030182
38MP0010368_abnormal_lymphatic_system1.76487337
39MP0003191_abnormal_cellular_cholesterol1.75289817
40MP0003300_gastrointestinal_ulcer1.69151069
41MP0001800_abnormal_humoral_immune1.67206050
42MP0004019_abnormal_vitamin_homeostasis1.65254395
43MP0005319_abnormal_enzyme/_coenzyme1.62312508
44MP0002277_abnormal_respiratory_mucosa1.62085937
45MP0001835_abnormal_antigen_presentation1.61291340
46MP0005645_abnormal_hypothalamus_physiol1.60745266
47MP0004142_abnormal_muscle_tone1.57925537
48MP0005167_abnormal_blood-brain_barrier1.54825224
49MP0005379_endocrine/exocrine_gland_phen1.53869991
50MP0005389_reproductive_system_phenotype1.50590446
51MP0008438_abnormal_cutaneous_collagen1.47937841
52MP0002160_abnormal_reproductive_system1.47165388
53MP0000516_abnormal_urinary_system1.45041053
54MP0005367_renal/urinary_system_phenotyp1.45041053
55MP0000604_amyloidosis1.43777734
56MP0002272_abnormal_nervous_system1.40709673
57MP0005253_abnormal_eye_physiology1.40607406
58MP0004510_myositis1.36771709
59MP0003787_abnormal_imprinting1.36693122
60MP0001919_abnormal_reproductive_system1.36633244
61MP0004133_heterotaxia1.35549393
62MP0001968_abnormal_touch/_nociception1.35443462
63MP0002723_abnormal_immune_serum1.34161360
64MP0002735_abnormal_chemical_nociception1.34005113
65MP0002751_abnormal_autonomic_nervous1.33943154
66MP0002736_abnormal_nociception_after1.33301646
67MP0009745_abnormal_behavioral_response1.32090092
68MP0008872_abnormal_physiological_respon1.30783031
69MP0000049_abnormal_middle_ear1.30049020
70MP0000631_abnormal_neuroendocrine_gland1.29409423
71MP0004885_abnormal_endolymph1.28770811
72MP0008877_abnormal_DNA_methylation1.26393160
73MP0005220_abnormal_exocrine_pancreas1.25787019
74MP0000598_abnormal_liver_morphology1.23383934
75MP0005584_abnormal_enzyme/coenzyme_acti1.22344912
76MP0003011_delayed_dark_adaptation1.21809474
77MP0010352_gastrointestinal_tract_polyps1.21557006
78MP0002452_abnormal_antigen_presenting1.20220438
79MP0009697_abnormal_copulation1.18110555
80MP0005310_abnormal_salivary_gland1.17345995
81MP0005023_abnormal_wound_healing1.17131489
82MP0009643_abnormal_urine_homeostasis1.14699574
83MP0009046_muscle_twitch1.10971509
84MP0005551_abnormal_eye_electrophysiolog1.10308121
85MP0001873_stomach_inflammation1.10021337
86MP0003303_peritoneal_inflammation1.10005185
87MP0005670_abnormal_white_adipose1.09346665
88MP0003436_decreased_susceptibility_to1.08277620
89MP0004145_abnormal_muscle_electrophysio1.08100813
90MP0002405_respiratory_system_inflammati1.03958245
91MP0001440_abnormal_grooming_behavior1.03693821
92MP0000026_abnormal_inner_ear1.02943353
93MP0009053_abnormal_anal_canal1.02763577
94MP0001502_abnormal_circadian_rhythm1.02747904
95MP0003329_amyloid_beta_deposits1.01715821
96MP0003119_abnormal_digestive_system1.01345173
97MP0009763_increased_sensitivity_to1.00432664
98MP0001764_abnormal_homeostasis0.99642805
99MP0002693_abnormal_pancreas_physiology0.99488901
100MP0009780_abnormal_chondrocyte_physiolo0.99300675
101MP0006276_abnormal_autonomic_nervous0.96094561
102MP0005451_abnormal_body_composition0.95963825
103MP0001542_abnormal_bone_strength0.94605885
104MP0009333_abnormal_splenocyte_physiolog0.94470788
105MP0002102_abnormal_ear_morphology0.94338952
106MP0010386_abnormal_urinary_bladder0.93317763
107MP0005025_abnormal_response_to0.93166168
108MP0002420_abnormal_adaptive_immunity0.93066969
109MP0001819_abnormal_immune_cell0.92307359
110MP0008789_abnormal_olfactory_epithelium0.91838437
111MP0009764_decreased_sensitivity_to0.90782137
112MP0003938_abnormal_ear_development0.90359569
113MP0000343_altered_response_to0.90196956
114MP0001963_abnormal_hearing_physiology0.89395288
115MP0001845_abnormal_inflammatory_respons0.88241020
116MP0005195_abnormal_posterior_eye0.87980701
117MP0001243_abnormal_dermal_layer0.87822311
118MP0005275_abnormal_skin_tensile0.86586601
119MP0002078_abnormal_glucose_homeostasis0.83927247
120MP0003279_aneurysm0.83224068
121MP0005084_abnormal_gallbladder_morpholo0.78065692
122MP0005248_abnormal_Harderian_gland0.78029294
123MP0002254_reproductive_system_inflammat0.77803718
124MP0002752_abnormal_somatic_nervous0.77547294
125MP0001970_abnormal_pain_threshold0.77475970
126MP0002168_other_aberrant_phenotype0.77362643
127MP0001727_abnormal_embryo_implantation0.77211223
128MP0000230_abnormal_systemic_arterial0.77195968
129MP0002064_seizures0.76678175
130MP0002928_abnormal_bile_duct0.75895888
131MP0004782_abnormal_surfactant_physiolog0.75146297
132MP0001944_abnormal_pancreas_morphology0.75074802
133MP0009642_abnormal_blood_homeostasis0.74325751
134MP0002184_abnormal_innervation0.73534186
135MP0001501_abnormal_sleep_pattern0.71714945
136MP0010155_abnormal_intestine_physiology0.71051463
137MP0006082_CNS_inflammation0.70929097
138MP0008469_abnormal_protein_level0.70591583
139MP0001881_abnormal_mammary_gland0.70507452
140MP0003567_abnormal_fetal_cardiomyocyte0.70316616
141MP0002557_abnormal_social/conspecific_i0.69724552
142MP0000383_abnormal_hair_follicle0.69551278
143MP0005647_abnormal_sex_gland0.68769102
144MP0009384_cardiac_valve_regurgitation0.68646602
145MP0004272_abnormal_basement_membrane0.68387824
146MP0000955_abnormal_spinal_cord0.66851985
147MP0003566_abnormal_cell_adhesion0.66284071
148MP0002295_abnormal_pulmonary_circulatio0.65387717
149MP0002060_abnormal_skin_morphology0.65345387
150MP0001853_heart_inflammation0.65328575
151MP0005448_abnormal_energy_balance0.64758045
152MP0009765_abnormal_xenobiotic_induced0.63534696
153MP0005334_abnormal_fat_pad0.63366492
154MP0003186_abnormal_redox_activity0.61171917
155MP0005408_hypopigmentation0.61031917
156MP0005187_abnormal_penis_morphology0.60437329
157MP0001661_extended_life_span0.60291114
158MP0000249_abnormal_blood_vessel0.60258564
159MP0001533_abnormal_skeleton_physiology0.59657327
160MP0002971_abnormal_brown_adipose0.58292110
161MP0005376_homeostasis/metabolism_phenot0.57382765
162MP0003091_abnormal_cell_migration0.56003246
163MP0005636_abnormal_mineral_homeostasis0.55784445
164MP0005395_other_phenotype0.55705498
165MP0002090_abnormal_vision0.55213995
166MP0002896_abnormal_bone_mineralization0.54270457
167MP0003656_abnormal_erythrocyte_physiolo0.52817558
168MP0002089_abnormal_postnatal_growth/wei0.51266920
169MP0004130_abnormal_muscle_cell0.48919258
170MP0008961_abnormal_basal_metabolism0.48305125
171MP0004947_skin_inflammation0.47643580
172MP0002877_abnormal_melanocyte_morpholog0.47187989
173MP0000013_abnormal_adipose_tissue0.46237396
174MP0001756_abnormal_urination0.46208695
175MP0005164_abnormal_response_to0.46099397
176MP0005257_abnormal_intraocular_pressure0.45907211
177MP0003075_altered_response_to0.44968433
178MP0008873_increased_physiological_sensi0.44919803
179MP0003453_abnormal_keratinocyte_physiol0.44710609
180MP0000639_abnormal_adrenal_gland0.43364554
181MP0005464_abnormal_platelet_physiology0.43253189
182MP0003959_abnormal_lean_body0.42741266
183MP0005666_abnormal_adipose_tissue0.41327103
184MP0000685_abnormal_immune_system0.40502326
185MP0001958_emphysema0.39483802
186MP0009672_abnormal_birth_weight0.39357270

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.60628556
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.96603326
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.20798899
4Intrahepatic cholestasis (HP:0001406)6.14698190
5Xanthomatosis (HP:0000991)6.07850141
6Hypobetalipoproteinemia (HP:0003563)5.89702271
7Prolonged partial thromboplastin time (HP:0003645)5.68739100
8Hyperlipoproteinemia (HP:0010980)4.99147776
9Hypolipoproteinemia (HP:0010981)4.54860094
10Abnormality of the common coagulation pathway (HP:0010990)4.54736262
11Joint hemorrhage (HP:0005261)4.32081787
12Hypoalphalipoproteinemia (HP:0003233)4.15508739
13Epidermoid cyst (HP:0200040)4.05005138
14Hypoglycemic coma (HP:0001325)4.04252132
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.03470745
16Complement deficiency (HP:0004431)4.00010209
17Abnormality of the intrinsic pathway (HP:0010989)3.97432884
18Ketosis (HP:0001946)3.80621692
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78355564
20Short 1st metacarpal (HP:0010034)3.76626744
21Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.76626744
22Hyperammonemia (HP:0001987)3.73381249
23Abnormality of methionine metabolism (HP:0010901)3.60958476
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.59533176
25Myocardial infarction (HP:0001658)3.55163999
26Short hallux (HP:0010109)3.54835881
27Congenital, generalized hypertrichosis (HP:0004540)3.50357685
28Stomatitis (HP:0010280)3.36768279
29Pendular nystagmus (HP:0012043)3.36239667
30Stenosis of the external auditory canal (HP:0000402)3.34517833
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.34100434
32Aplasia/Hypoplasia of the hallux (HP:0008362)3.32012842
33Abnormality of the 1st metacarpal (HP:0010009)3.26445363
34Hypercholesterolemia (HP:0003124)3.25170069
35Fat malabsorption (HP:0002630)3.22906232
36Hypoglycemic seizures (HP:0002173)3.20643619
37Abnormality of pyrimidine metabolism (HP:0004353)3.14369217
38Hyperglycinemia (HP:0002154)3.13708013
39Abnormality of complement system (HP:0005339)3.12762572
40Conjugated hyperbilirubinemia (HP:0002908)3.06273912
41Peritonitis (HP:0002586)3.05178781
42Anomalous pulmonary venous return (HP:0010772)3.05061773
43Acute necrotizing encephalopathy (HP:0006965)3.03301313
44Mitral stenosis (HP:0001718)3.01684627
45Esophageal varix (HP:0002040)3.00848061
46Skin nodule (HP:0200036)3.00322954
47Fused cervical vertebrae (HP:0002949)3.00165197
48Hepatocellular carcinoma (HP:0001402)2.99346014
49Congenital stationary night blindness (HP:0007642)2.99256075
50Protrusio acetabuli (HP:0003179)2.92342181
51Hyperbilirubinemia (HP:0002904)2.83963271
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82287392
53Abnormality of the pulmonary veins (HP:0011718)2.79422657
54Abnormality of glycine metabolism (HP:0010895)2.76787265
55Abnormality of serine family amino acid metabolism (HP:0010894)2.76787265
56Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.76063247
57Abnormality of nucleobase metabolism (HP:0010932)2.75151271
58Abolished electroretinogram (ERG) (HP:0000550)2.72874223
59Ketoacidosis (HP:0001993)2.71719968
60Menorrhagia (HP:0000132)2.69882600
61Absent thumb (HP:0009777)2.69231625
62Spontaneous abortion (HP:0005268)2.68080888
63Vascular calcification (HP:0004934)2.65736276
64Rib fusion (HP:0000902)2.65641564
65IgG deficiency (HP:0004315)2.65097068
66Mitochondrial inheritance (HP:0001427)2.64953592
67Cardiovascular calcification (HP:0011915)2.64590872
68Abnormal mitochondria in muscle tissue (HP:0008316)2.64234789
69Hyperinsulinemic hypoglycemia (HP:0000825)2.63322686
70Progressive macrocephaly (HP:0004481)2.62284554
71Pancreatic cysts (HP:0001737)2.61065852
72Spastic diplegia (HP:0001264)2.56401641
73Hyperglycinuria (HP:0003108)2.55600560
74Abnormality of purine metabolism (HP:0004352)2.55542299
75Abnormality of the phalanges of the 5th finger (HP:0004213)2.53678389
76Abnormality of the renal collecting system (HP:0004742)2.51386179
77Abnormal number of erythroid precursors (HP:0012131)2.50234493
78Late onset (HP:0003584)2.49472286
79Abnormality of fatty-acid metabolism (HP:0004359)2.47224704
80Adactyly (HP:0009776)2.46236799
81Abnormality of the proximal phalanges of the hand (HP:0009834)2.45975441
82Gout (HP:0001997)2.42466497
83Delayed CNS myelination (HP:0002188)2.39792636
84Vertebral fusion (HP:0002948)2.38156646
85Abnormality of the middle phalanges of the toes (HP:0010183)2.36533415
86Reticulocytopenia (HP:0001896)2.35415391
87Short phalanx of the thumb (HP:0009660)2.34996814
88Abnormal gallbladder morphology (HP:0012437)2.34286678
89Methylmalonic acidemia (HP:0002912)2.33689887
90Abnormality of serum amino acid levels (HP:0003112)2.33177442
91Cholecystitis (HP:0001082)2.32856143
92Abnormal gallbladder physiology (HP:0012438)2.32856143
93Back pain (HP:0003418)2.32164445
94Abnormality of the phalanges of the 2nd finger (HP:0009541)2.31921556
95Pancreatic fibrosis (HP:0100732)2.31568648
96Ectopic kidney (HP:0000086)2.30779423
97Premature rupture of membranes (HP:0001788)2.30568712
98Congenital sensorineural hearing impairment (HP:0008527)2.28525098
99Increased CSF lactate (HP:0002490)2.27716346
100Hyperglycemia (HP:0003074)2.27342888
101Acute encephalopathy (HP:0006846)2.26429520
102Abnormality of cells of the erythroid lineage (HP:0012130)2.25807661
103True hermaphroditism (HP:0010459)2.25219419
104Cholelithiasis (HP:0001081)2.24663204
105Increased mean platelet volume (HP:0011877)2.23458440
106Nephronophthisis (HP:0000090)2.23262540
107Abnormal rod and cone electroretinograms (HP:0008323)2.23040119
108Symphalangism affecting the phalanges of the hand (HP:0009773)2.21928124
1093-Methylglutaconic aciduria (HP:0003535)2.21835179
110Abnormality of the nasal septum (HP:0000419)2.21093496
111Asplenia (HP:0001746)2.20082369
112Steatorrhea (HP:0002570)2.19165610
113Adrenal hypoplasia (HP:0000835)2.18243615
114Hypoplasia of the uterus (HP:0000013)2.17709012
115Aplasia/Hypoplasia of the spleen (HP:0010451)2.17205132
116Aplasia/hypoplasia of the uterus (HP:0008684)2.16743220
117Malnutrition (HP:0004395)2.15942000
118Symptomatic seizures (HP:0011145)2.14771296
119Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13545714
120Abnormality of midbrain morphology (HP:0002418)2.11386911
121Molar tooth sign on MRI (HP:0002419)2.11386911
122Hypochromic microcytic anemia (HP:0004840)2.10589351
123Methylmalonic aciduria (HP:0012120)2.09201845
124Irritability (HP:0000737)2.09146241
125Sensorimotor neuropathy (HP:0007141)2.06742444
126Abnormal cartilage morphology (HP:0002763)2.05582578
127Hydroxyprolinuria (HP:0003080)2.04449216
128Abnormality of proline metabolism (HP:0010907)2.04449216
129Increased hepatocellular lipid droplets (HP:0006565)2.03612376
130Ectopia lentis (HP:0001083)2.03524672
131Hemorrhage of the eye (HP:0011885)2.03254495
132Carpal bone hypoplasia (HP:0001498)2.01914014
133Polycythemia (HP:0001901)2.01892343
134Metabolic acidosis (HP:0001942)2.01299541
135Chorioretinal atrophy (HP:0000533)2.00765767
136Thyroiditis (HP:0100646)2.00678745
137Neonatal onset (HP:0003623)2.00497260
138Lipid accumulation in hepatocytes (HP:0006561)2.00436970
139Abnormality of the Achilles tendon (HP:0005109)2.00366249
140Glomerulonephritis (HP:0000099)1.98081759
141Optic disc pallor (HP:0000543)1.97473988
142Hypoplasia of the ulna (HP:0003022)1.96902931
143Gingival bleeding (HP:0000225)1.95648646
144Aplasia/Hypoplasia involving the musculature (HP:0001460)1.94010123
145Porencephaly (HP:0002132)1.93144083
146Horseshoe kidney (HP:0000085)1.92167486
147Synostosis of carpal bones (HP:0005048)1.92003465
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90448237
149Abnormal platelet volume (HP:0011876)1.89688547
150Thrombophlebitis (HP:0004418)1.89159992
151Increased IgM level (HP:0003496)1.85497789
152Abnormality of the renal medulla (HP:0100957)1.84675746
153Amyloidosis (HP:0011034)1.84661358
154Maternal diabetes (HP:0009800)1.83731495
155Abnormality of DNA repair (HP:0003254)1.83622879
156Reticulocytosis (HP:0001923)1.83281681
157Abnormality of the gallbladder (HP:0005264)1.82268538
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81596529
159Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.81575415
160Increased corneal curvature (HP:0100692)1.81574351
161Keratoconus (HP:0000563)1.81574351
162Opisthotonus (HP:0002179)1.81454555
163Abnormal pancreas size (HP:0012094)1.80569008
164Severe combined immunodeficiency (HP:0004430)1.80371802
165Renal Fanconi syndrome (HP:0001994)1.79535824
166Alveolar cell carcinoma (HP:0006519)1.78912748
167Enlarged kidneys (HP:0000105)1.78754021
168Joint swelling (HP:0001386)1.78222020
169Medial flaring of the eyebrow (HP:0010747)1.77748850
170Pancreatitis (HP:0001733)1.76618812
171Retrobulbar optic neuritis (HP:0100654)1.76486081
172Optic neuritis (HP:0100653)1.76486081
173Prostate neoplasm (HP:0100787)1.76253196
174Acanthocytosis (HP:0001927)1.76229183
175Infantile muscular hypotonia (HP:0008947)1.75788330
176Abnormality of iron homeostasis (HP:0011031)1.75494974
177Stroke (HP:0001297)1.75178481
178Tachypnea (HP:0002789)1.75027978
179Abnormal enzyme/coenzyme activity (HP:0012379)1.74322583
180Absent phalangeal crease (HP:0006109)1.74316242
181Protuberant abdomen (HP:0001538)1.74255416
182Progressive cerebellar ataxia (HP:0002073)1.73227096
183Turricephaly (HP:0000262)1.72422450
184Acute hepatic failure (HP:0006554)1.71732892
185Morphological abnormality of the middle ear (HP:0008609)1.71363247
186Duplicated collecting system (HP:0000081)1.70878365
187Abnormality of transition element cation homeostasis (HP:0011030)1.69539872
188Brushfield spots (HP:0001088)1.69212177
189Concave nail (HP:0001598)1.66583875
190Abnormality of eosinophils (HP:0001879)1.66526237
191Hemiplegia (HP:0002301)1.65270417
192Synostosis involving the elbow (HP:0003938)1.64864210
193Humeroradial synostosis (HP:0003041)1.64864210
194Stomach cancer (HP:0012126)1.64366865
195Furrowed tongue (HP:0000221)1.63341781
196Erythroderma (HP:0001019)1.62720880
197Oral leukoplakia (HP:0002745)1.61779980
198Agitation (HP:0000713)1.60977963
199Severe muscular hypotonia (HP:0006829)1.60846118
200Cerebral edema (HP:0002181)1.60706027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.40290621
2ERN14.32952602
3FGFR43.97413033
4GRK13.69190355
5TRIB33.59427915
6BCKDK3.41155639
7SIK13.33969335
8PKN23.09591768
9EPHA23.01129448
10TLK12.93400685
11INSRR2.64544625
12ZAK2.44377699
13GRK72.23814920
14PTK62.07756438
15TAF11.98281386
16NME21.92359890
17EPHA31.87474594
18PDGFRA1.81762035
19LATS11.80243407
20PTK21.78405415
21MAP4K21.77793002
22FLT31.76090652
23ERBB41.72643233
24RIPK11.71297959
25NUAK11.69190106
26IRAK31.69005026
27MAP3K31.67464819
28BLK1.66787920
29KDR1.65781828
30STK161.64869934
31BMPR1B1.61097439
32VRK21.58113487
33STK241.57976430
34IKBKE1.50970356
35FGFR31.47164033
36FGFR11.42965329
37PIK3CG1.42756569
38MAP3K71.41071263
39ITK1.39205585
40EPHB11.38724529
41PAK21.38713204
42TAOK31.36756667
43TAOK21.36047110
44PLK21.33543353
45DYRK31.32189256
46PAK31.28366196
47MAP3K111.26822119
48MAP2K31.25585566
49ZAP701.23751991
50JAK31.22852595
51TAOK11.21034864
52VRK11.19743491
53DYRK1B1.15229807
54MAP3K141.15031581
55MAP4K11.14058409
56WNK31.13431891
57TNIK1.12909123
58PDK21.12641467
59MAP2K71.12168249
60DYRK21.10287221
61NME11.09670664
62CDK91.09355318
63MST1R1.08414474
64TTN1.06024884
65MAP3K101.05927017
66FER1.00616736
67PIM21.00570790
68PASK1.00169382
69TYK20.98879270
70PRKCG0.98344489
71MKNK20.96120075
72TBK10.96070063
73MTOR0.95884484
74PINK10.93833792
75MET0.92285470
76CHUK0.91425983
77DDR20.91235160
78JAK10.89544372
79MAP3K90.88533703
80BMX0.88326188
81PKN10.85840325
82SYK0.85440741
83GSK3A0.85107765
84RPS6KA50.84694861
85IRAK40.84058134
86MAP3K40.82954323
87MAPK150.82866364
88MUSK0.82502935
89GRK50.82296081
90TXK0.78534430
91JAK20.77915549
92ADRBK10.77205732
93LATS20.77081347
94PIM10.77028764
95NEK90.76126429
96TEC0.74776654
97PRKCH0.74071690
98ACVR1B0.73335236
99KIT0.72459743
100FRK0.72004642
101RPS6KA40.70635696
102RPS6KA60.70431518
103MAP2K40.70014251
104LRRK20.69934544
105LCK0.69426937
106ABL20.68557831
107NTRK20.66447500
108EEF2K0.66208175
109CDC70.65839863
110MST40.65485746
111CDK60.65251356
112BMPR20.65090219
113FGFR20.64743729
114MAP2K10.64588312
115TIE10.64430305
116MATK0.64066861
117NTRK10.63119032
118EPHB20.63036551
119PRKCQ0.62615247
120* LYN0.61881506
121CSNK1G20.61654141
122TGFBR20.61554952
123MAPK110.59328994
124IGF1R0.59013969
125CSNK1A10.58733658
126RET0.58428304
127DAPK30.56563509
128MAP3K10.56378046
129PDGFRB0.55370812
130HIPK20.54930648
131PRKCE0.54020118
132PRKACA0.53091157
133MKNK10.52821439
134CSNK1G30.52257883
135MAPKAPK50.49723557
136CAMK2A0.49621229
137PRKCZ0.49062019
138CSNK1G10.47921174
139PAK60.47649671
140TGFBR10.46856161
141BTK0.46579463
142ICK0.45581337
143CAMKK20.45342635
144RPS6KL10.45259754
145RPS6KC10.45259754
146PRKAA20.44517294
147PRKACG0.44127265
148* INSR0.43720444
149DAPK20.42982787
150AURKA0.42786300
151RIPK40.42602615
152CAMK1D0.42420087
153TESK10.40558365
154TESK20.40300186
155CSNK2A10.40155741
156ERBB20.40106046
157MAPK70.40084484
158PTK2B0.39985157
159MOS0.39934779
160STK38L0.39696897
161MAP3K50.39433510
162SGK20.38653907
163PRKCD0.38090289
164PRKG20.35990108
165MAPK130.35577498
166CASK0.35012779
167CAMK1G0.34997214
168PRKCA0.34960419
169IKBKB0.34600622
170MAPK40.34579972
171* CSK0.34024988
172IRAK10.33454751
173PRKCI0.33448834
174GRK60.32886005
175HCK0.31985055
176STK100.31780298
177PAK40.31337485

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.38307690
2Nitrogen metabolism_Homo sapiens_hsa009103.75236922
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.61570053
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.54874175
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.25199656
6Arginine biosynthesis_Homo sapiens_hsa002203.11312649
7Asthma_Homo sapiens_hsa053103.03468044
8Allograft rejection_Homo sapiens_hsa053302.88440510
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.88391531
10Complement and coagulation cascades_Homo sapiens_hsa046102.85653569
11Oxidative phosphorylation_Homo sapiens_hsa001902.82091922
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.65791748
13Tryptophan metabolism_Homo sapiens_hsa003802.58523637
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58180481
15Autoimmune thyroid disease_Homo sapiens_hsa053202.53146480
16Ribosome_Homo sapiens_hsa030102.45488604
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38957986
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36720705
19Fatty acid degradation_Homo sapiens_hsa000712.33956043
20Graft-versus-host disease_Homo sapiens_hsa053322.29595193
21Rheumatoid arthritis_Homo sapiens_hsa053232.28162717
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.22359414
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19412460
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.13475868
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11277124
26Parkinsons disease_Homo sapiens_hsa050122.11097504
27Butanoate metabolism_Homo sapiens_hsa006502.10054026
28Primary immunodeficiency_Homo sapiens_hsa053402.01467060
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00489689
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94973009
31Chemical carcinogenesis_Homo sapiens_hsa052041.93321932
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.91385657
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.82509052
34PPAR signaling pathway_Homo sapiens_hsa033201.80405706
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.78192302
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77305974
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75311811
38Protein export_Homo sapiens_hsa030601.74203862
39Peroxisome_Homo sapiens_hsa041461.73938760
40Selenocompound metabolism_Homo sapiens_hsa004501.71913076
41Phototransduction_Homo sapiens_hsa047441.70685862
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70626192
43Fatty acid metabolism_Homo sapiens_hsa012121.69324751
44Histidine metabolism_Homo sapiens_hsa003401.69203626
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68376034
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.67195106
47Staphylococcus aureus infection_Homo sapiens_hsa051501.66216768
48Bile secretion_Homo sapiens_hsa049761.64580203
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62559194
50Collecting duct acid secretion_Homo sapiens_hsa049661.62471856
51Retinol metabolism_Homo sapiens_hsa008301.59636769
52Caffeine metabolism_Homo sapiens_hsa002321.57179552
53Phenylalanine metabolism_Homo sapiens_hsa003601.47428061
54Alzheimers disease_Homo sapiens_hsa050101.47221648
55beta-Alanine metabolism_Homo sapiens_hsa004101.46002992
56Propanoate metabolism_Homo sapiens_hsa006401.43412282
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41753937
58Cardiac muscle contraction_Homo sapiens_hsa042601.31109717
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29509902
60Proteasome_Homo sapiens_hsa030501.27379218
61Starch and sucrose metabolism_Homo sapiens_hsa005001.27002043
62Hematopoietic cell lineage_Homo sapiens_hsa046401.26477470
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26030246
64Sulfur metabolism_Homo sapiens_hsa009201.25974235
65Biosynthesis of amino acids_Homo sapiens_hsa012301.25688018
66Tyrosine metabolism_Homo sapiens_hsa003501.25271366
67Pyruvate metabolism_Homo sapiens_hsa006201.22261016
68Huntingtons disease_Homo sapiens_hsa050161.22247966
69RNA polymerase_Homo sapiens_hsa030201.20769891
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20531253
71Jak-STAT signaling pathway_Homo sapiens_hsa046301.16717340
72ABC transporters_Homo sapiens_hsa020101.16541279
73Basal transcription factors_Homo sapiens_hsa030221.16241970
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15555492
75Cysteine and methionine metabolism_Homo sapiens_hsa002701.10012531
76Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09077541
77African trypanosomiasis_Homo sapiens_hsa051431.08050145
78Fat digestion and absorption_Homo sapiens_hsa049751.07183756
79Cyanoamino acid metabolism_Homo sapiens_hsa004601.05629838
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04541406
81Nicotine addiction_Homo sapiens_hsa050331.00773572
82RNA degradation_Homo sapiens_hsa030180.98431716
83Carbon metabolism_Homo sapiens_hsa012000.98138724
84Fatty acid elongation_Homo sapiens_hsa000620.97122402
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96296631
86Arginine and proline metabolism_Homo sapiens_hsa003300.95691788
87Folate biosynthesis_Homo sapiens_hsa007900.92694821
88Measles_Homo sapiens_hsa051620.92186049
89Lysine degradation_Homo sapiens_hsa003100.90160547
90Notch signaling pathway_Homo sapiens_hsa043300.89364993
91Steroid biosynthesis_Homo sapiens_hsa001000.88946773
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85907938
93Morphine addiction_Homo sapiens_hsa050320.84948263
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84516867
95Systemic lupus erythematosus_Homo sapiens_hsa053220.84466043
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77926924
97One carbon pool by folate_Homo sapiens_hsa006700.77321999
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75605022
99Sulfur relay system_Homo sapiens_hsa041220.74324462
100Vitamin digestion and absorption_Homo sapiens_hsa049770.73125927
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71521769
102Dorso-ventral axis formation_Homo sapiens_hsa043200.64681364
103Homologous recombination_Homo sapiens_hsa034400.63969599
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63680325
105Antigen processing and presentation_Homo sapiens_hsa046120.63584025
106Insulin secretion_Homo sapiens_hsa049110.56018556
107Fanconi anemia pathway_Homo sapiens_hsa034600.55842744
108Leishmaniasis_Homo sapiens_hsa051400.52413832
109Olfactory transduction_Homo sapiens_hsa047400.52229902
110Glycerolipid metabolism_Homo sapiens_hsa005610.51038002
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50935869
112Osteoclast differentiation_Homo sapiens_hsa043800.49823018
113Herpes simplex infection_Homo sapiens_hsa051680.48791497
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48188758
115Pertussis_Homo sapiens_hsa051330.47633586
116p53 signaling pathway_Homo sapiens_hsa041150.47575928
117Prion diseases_Homo sapiens_hsa050200.47322812
118Chemokine signaling pathway_Homo sapiens_hsa040620.45970597
119Taste transduction_Homo sapiens_hsa047420.45775334
120Ovarian steroidogenesis_Homo sapiens_hsa049130.45048386
121Mineral absorption_Homo sapiens_hsa049780.44178692
122Basal cell carcinoma_Homo sapiens_hsa052170.44115740
123GABAergic synapse_Homo sapiens_hsa047270.44011933
124Pentose phosphate pathway_Homo sapiens_hsa000300.42554424
125Bladder cancer_Homo sapiens_hsa052190.42214204
126Insulin resistance_Homo sapiens_hsa049310.42174083
127Circadian entrainment_Homo sapiens_hsa047130.41011311
128Ether lipid metabolism_Homo sapiens_hsa005650.40229089
129Serotonergic synapse_Homo sapiens_hsa047260.40143546
130Vitamin B6 metabolism_Homo sapiens_hsa007500.39795798
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39753084
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39126089
133Legionellosis_Homo sapiens_hsa051340.37798546
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.37589925
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36690208
136Fatty acid biosynthesis_Homo sapiens_hsa000610.34552675
137Glutamatergic synapse_Homo sapiens_hsa047240.33233307
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32249792
139Cholinergic synapse_Homo sapiens_hsa047250.32108975
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31551652
141TGF-beta signaling pathway_Homo sapiens_hsa043500.31186894
142Influenza A_Homo sapiens_hsa051640.30631196
143MAPK signaling pathway_Homo sapiens_hsa040100.30564887
144Epstein-Barr virus infection_Homo sapiens_hsa051690.29593098
145Glutathione metabolism_Homo sapiens_hsa004800.28651427
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26157489
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25854850
148Tuberculosis_Homo sapiens_hsa051520.24778703
149ECM-receptor interaction_Homo sapiens_hsa045120.20453166
150Metabolic pathways_Homo sapiens_hsa011000.19765834
151Glucagon signaling pathway_Homo sapiens_hsa049220.18243055
152Galactose metabolism_Homo sapiens_hsa000520.17988138
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16768608
154Type I diabetes mellitus_Homo sapiens_hsa049400.16405169
155Fructose and mannose metabolism_Homo sapiens_hsa000510.15014196
156Amoebiasis_Homo sapiens_hsa051460.13299839
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.12593537
158Malaria_Homo sapiens_hsa051440.11591978
159TNF signaling pathway_Homo sapiens_hsa046680.11325876
160Prolactin signaling pathway_Homo sapiens_hsa049170.10551890
161Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08612157
162AMPK signaling pathway_Homo sapiens_hsa041520.08347525
163Small cell lung cancer_Homo sapiens_hsa052220.04962183
164Focal adhesion_Homo sapiens_hsa045100.03385209
165Proteoglycans in cancer_Homo sapiens_hsa052050.01865788
166AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0822473
167Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0729335
168Linoleic acid metabolism_Homo sapiens_hsa00591-0.0661414
169Type II diabetes mellitus_Homo sapiens_hsa04930-0.0588278
170PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0582852
171T cell receptor signaling pathway_Homo sapiens_hsa04660-0.0578345
172Insulin signaling pathway_Homo sapiens_hsa04910-0.0517897
173Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0496680
174Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0476650
175alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0166339

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