RGS11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.08037699
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.57863678
3COPI coating of Golgi vesicle (GO:0048205)5.14468656
4Golgi transport vesicle coating (GO:0048200)5.14468656
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04975556
6locomotory exploration behavior (GO:0035641)4.89225028
7sodium ion export (GO:0071436)4.73793469
8axon ensheathment in central nervous system (GO:0032291)4.61842639
9central nervous system myelination (GO:0022010)4.61842639
10regulation of synaptic vesicle exocytosis (GO:2000300)4.56684145
11detection of light stimulus involved in sensory perception (GO:0050962)4.42996858
12detection of light stimulus involved in visual perception (GO:0050908)4.42996858
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.38451764
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.37574444
15vocalization behavior (GO:0071625)4.36508599
16regulation of neuronal synaptic plasticity (GO:0048168)4.35297993
17cerebellar granule cell differentiation (GO:0021707)4.31638569
18L-amino acid import (GO:0043092)4.30595772
19negative regulation of synaptic transmission, GABAergic (GO:0032229)4.29488519
20synaptic vesicle exocytosis (GO:0016079)4.29309571
21detection of calcium ion (GO:0005513)4.14556609
22neuronal ion channel clustering (GO:0045161)4.14260530
23protein maturation by protein folding (GO:0022417)4.08984224
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04283883
25dendritic spine morphogenesis (GO:0060997)4.02992977
26cellular potassium ion homeostasis (GO:0030007)4.02938923
27exploration behavior (GO:0035640)4.02900109
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.01084802
29neurotransmitter transport (GO:0006836)3.99146593
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.98856721
31lactate metabolic process (GO:0006089)3.96807644
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.96436346
33insulin secretion (GO:0030073)3.95553270
34urinary tract smooth muscle contraction (GO:0014848)3.90101725
35endocrine pancreas development (GO:0031018)3.87417719
36regulation of synaptic vesicle transport (GO:1902803)3.86851121
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.84585390
38regulation of synapse structural plasticity (GO:0051823)3.80314253
39regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.79283761
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.77844605
41potassium ion import (GO:0010107)3.77127867
42regulation of neurotransmitter levels (GO:0001505)3.75658188
43auditory behavior (GO:0031223)3.70805175
44regulation of glutamate receptor signaling pathway (GO:1900449)3.70016816
45retinal rod cell development (GO:0046548)3.69909059
46amino acid import (GO:0043090)3.68542772
47regulation of dopamine metabolic process (GO:0042053)3.64082901
48regulation of catecholamine metabolic process (GO:0042069)3.64082901
49protein retention in ER lumen (GO:0006621)3.62260273
50exocrine pancreas development (GO:0031017)3.54297730
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.53705794
52synaptic vesicle endocytosis (GO:0048488)3.50131913
53positive regulation of synapse maturation (GO:0090129)3.49244080
54protein localization to synapse (GO:0035418)3.49218747
55positive regulation of dendritic spine development (GO:0060999)3.48952351
56regulation of ARF protein signal transduction (GO:0032012)3.48251375
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45419795
58negative regulation of cytosolic calcium ion concentration (GO:0051481)3.45368801
59neuromuscular process controlling balance (GO:0050885)3.43334403
60regulation of voltage-gated calcium channel activity (GO:1901385)3.41887015
61regulation of type B pancreatic cell apoptotic process (GO:2000674)3.41260210
62regulation of uterine smooth muscle contraction (GO:0070472)3.39946156
63proline transport (GO:0015824)3.38730869
64synaptic vesicle maturation (GO:0016188)3.35014872
65retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.33511331
66regulation of neurotransmitter transport (GO:0051588)3.32258890
67positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.32079285
68intraciliary transport (GO:0042073)3.31306765
69innervation (GO:0060384)3.31030321
70regulation of synaptic plasticity (GO:0048167)3.30084888
71membrane depolarization during action potential (GO:0086010)3.29119762
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27571151
73regulation of postsynaptic membrane potential (GO:0060078)3.27048736
74glutamate secretion (GO:0014047)3.23791830
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22724291
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21986910
77potassium ion homeostasis (GO:0055075)3.21678315
78ER overload response (GO:0006983)3.21385525
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.20952627
80membrane depolarization (GO:0051899)3.20530447
81signal peptide processing (GO:0006465)3.19467027
82cellular sodium ion homeostasis (GO:0006883)3.17603782
83regulation of insulin secretion (GO:0050796)3.16329130
84transmission of nerve impulse (GO:0019226)3.14830770
85regulation of vesicle fusion (GO:0031338)3.12631943
86neurotransmitter-gated ion channel clustering (GO:0072578)3.12550463
87dendritic spine organization (GO:0097061)3.12380370
88synaptic transmission, glutamatergic (GO:0035249)3.12228950
89regulation of calcium ion-dependent exocytosis (GO:0017158)3.12132332
90positive regulation of uterine smooth muscle contraction (GO:0070474)3.11417185
91membrane hyperpolarization (GO:0060081)3.10195974
92peptide hormone processing (GO:0016486)3.08419265
93COPII vesicle coating (GO:0048208)3.07148959
94neurotransmitter uptake (GO:0001504)3.06957064
95neuron-neuron synaptic transmission (GO:0007270)3.06582104
96chemosensory behavior (GO:0007635)3.06507956
97positive regulation of exocytosis (GO:0045921)3.05028532
98gamma-aminobutyric acid transport (GO:0015812)3.04320114
99regulation of dendritic spine morphogenesis (GO:0061001)3.02855062
100regulation of synapse maturation (GO:0090128)3.01998911
101gamma-aminobutyric acid signaling pathway (GO:0007214)3.00487880
102mating behavior (GO:0007617)3.00219032
103acidic amino acid transport (GO:0015800)2.99424904
104glandular epithelial cell differentiation (GO:0002067)2.97087038
105negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.96179487
106long term synaptic depression (GO:0060292)2.94651119
107regulation of glucocorticoid secretion (GO:2000849)2.93243232
108long-term memory (GO:0007616)2.92705445
109neuromuscular process controlling posture (GO:0050884)2.92022750
110response to auditory stimulus (GO:0010996)2.91246798
111striatum development (GO:0021756)2.90531235
112tachykinin receptor signaling pathway (GO:0007217)2.89972227
113positive regulation of dendrite development (GO:1900006)2.89845736
114cell migration in hindbrain (GO:0021535)2.89590054
115activation of protein kinase A activity (GO:0034199)2.88591839
116positive regulation of insulin secretion (GO:0032024)2.88290177
117regulation of peptide hormone secretion (GO:0090276)2.88026817
118regulation of dendritic spine development (GO:0060998)2.87496648
119regulation of synaptic transmission (GO:0050804)2.87174332
120cell differentiation in hindbrain (GO:0021533)2.86994190
121neuromuscular synaptic transmission (GO:0007274)2.85809019
122cerebellar Purkinje cell layer development (GO:0021680)2.85540814
123calcium ion import (GO:0070509)2.85374452
124regulation of peptide secretion (GO:0002791)2.83935317
125presynaptic membrane organization (GO:0097090)2.83810934
126synaptic vesicle transport (GO:0048489)2.82933050
127establishment of synaptic vesicle localization (GO:0097480)2.82933050
128synaptic transmission (GO:0007268)2.82850083
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.82635701
130cerebellar Purkinje cell differentiation (GO:0021702)2.81428089
131neuronal action potential propagation (GO:0019227)2.81367992
132signal release (GO:0023061)2.79724847
133layer formation in cerebral cortex (GO:0021819)2.77602179
134nitric oxide mediated signal transduction (GO:0007263)2.76849233
135photoreceptor cell maintenance (GO:0045494)2.76822719
136cell communication involved in cardiac conduction (GO:0086065)2.75967445
137positive regulation of vesicle fusion (GO:0031340)2.75781351
138neurotransmitter secretion (GO:0007269)2.75376249
139regulation of synaptic transmission, glutamatergic (GO:0051966)2.75258349
140regulation of oxidative phosphorylation (GO:0002082)2.73991442
141behavioral response to ethanol (GO:0048149)2.73950002
142regulation of exocytosis (GO:0017157)2.73523320
143photoreceptor cell development (GO:0042461)2.72955121
144eye photoreceptor cell development (GO:0042462)2.71856390
145cell communication by electrical coupling (GO:0010644)2.70405583
146positive regulation of membrane potential (GO:0045838)2.69283787
147peptide hormone secretion (GO:0030072)2.68442161
148positive regulation of dendritic spine morphogenesis (GO:0061003)2.68191338
149GDP-mannose metabolic process (GO:0019673)2.67410531
150regulation of neurotransmitter secretion (GO:0046928)2.65999045
151neuron cell-cell adhesion (GO:0007158)2.64812243
152positive regulation of neurotransmitter transport (GO:0051590)2.61518511
153cellular response to glucagon stimulus (GO:0071377)2.60903686
154phosphorelay signal transduction system (GO:0000160)2.59905356
155regulation of hormone secretion (GO:0046883)2.59721359
156postsynaptic membrane organization (GO:0001941)2.59387434
157vesicle coating (GO:0006901)2.59287053
158nonmotile primary cilium assembly (GO:0035058)2.59225194
159peptide secretion (GO:0002790)2.56884781
160positive regulation of neurotransmitter secretion (GO:0001956)2.54215092
161glutamate receptor signaling pathway (GO:0007215)2.53750842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.07766563
2EZH2_22144423_ChIP-Seq_EOC_Human3.98463749
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.46651350
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96385506
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.92386255
6REST_21632747_ChIP-Seq_MESCs_Mouse2.70082181
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51692757
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.41637176
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34496936
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20912466
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15295762
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11706823
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.11209738
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09929293
15TAF15_26573619_Chip-Seq_HEK293_Human2.05037930
16DROSHA_22980978_ChIP-Seq_HELA_Human2.00724445
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.00639436
18ERG_21242973_ChIP-ChIP_JURKAT_Human1.93241866
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92780125
20* RARB_27405468_Chip-Seq_BRAIN_Mouse1.90471023
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.88344818
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87023522
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86154758
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84900422
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83139421
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81968682
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78473955
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.76329744
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76059877
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.72793646
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71982202
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71308775
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71088225
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69490294
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66536943
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64986411
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64986411
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63551954
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.63034776
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.61866595
41KDM2B_26808549_Chip-Seq_K562_Human1.59249109
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58700599
43SMAD4_21799915_ChIP-Seq_A2780_Human1.58055562
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57955201
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51480973
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50998668
47P53_22127205_ChIP-Seq_FIBROBLAST_Human1.48703513
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48460437
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47485509
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.47394625
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46997673
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44328724
53STAT3_23295773_ChIP-Seq_U87_Human1.43287226
54P300_19829295_ChIP-Seq_ESCs_Human1.41553858
55VDR_22108803_ChIP-Seq_LS180_Human1.37062847
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36007257
57ZNF274_21170338_ChIP-Seq_K562_Hela1.34825618
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34108743
59TET1_21490601_ChIP-Seq_MESCs_Mouse1.33116848
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.32652673
61LXR_22292898_ChIP-Seq_THP-1_Human1.31728132
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28557631
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26742769
64CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24332977
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24205814
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20083881
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19376518
68TCF4_23295773_ChIP-Seq_U87_Human1.17601312
69AR_25329375_ChIP-Seq_VCAP_Human1.16916463
70OCT4_19829295_ChIP-Seq_ESCs_Human1.16552463
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14936053
72* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14814110
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14598469
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14406408
75BCAT_22108803_ChIP-Seq_LS180_Human1.12864211
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11767593
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08880981
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07212341
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.07010403
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06761606
81* SMC4_20622854_ChIP-Seq_HELA_Human1.06428938
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.06407141
83AR_21572438_ChIP-Seq_LNCaP_Human1.05861714
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04450373
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04402096
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03724216
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.03533281
88AR_19668381_ChIP-Seq_PC3_Human1.03306697
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02255292
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01743591
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01359676
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.01145950
93SMAD3_21741376_ChIP-Seq_ESCs_Human1.01001294
94P68_20966046_ChIP-Seq_HELA_Human0.99928986
95RNF2_27304074_Chip-Seq_NSC_Mouse0.99162353
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98717757
97REST_19997604_ChIP-ChIP_NEURONS_Mouse0.98663750
98FLI1_21867929_ChIP-Seq_TH2_Mouse0.98021225
99RUNX2_22187159_ChIP-Seq_PCA_Human0.97330441
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97224566
101TP53_22573176_ChIP-Seq_HFKS_Human0.96746141
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95879420
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94931738
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.94477069
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94109461
106KLF4_19829295_ChIP-Seq_ESCs_Human0.94059476
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92942580
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92641811
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91273547
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.91202509
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90932750
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.90916763
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90360602
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89624357
115* CTCF_27219007_Chip-Seq_Bcells_Human0.88396424
116CREB1_26743006_Chip-Seq_LNCaP_Human0.87853427
117SMAD4_21741376_ChIP-Seq_ESCs_Human0.87595740
118IGF1R_20145208_ChIP-Seq_DFB_Human0.87581467
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87408017
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87049733
121SOX2_18555785_Chip-Seq_ESCs_Mouse0.86565084
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86261511
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86114854
124AHR_22903824_ChIP-Seq_MCF-7_Human0.85381939
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.84664223
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84098613
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.83751774
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.83671003
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.83556965
130KDM2B_26808549_Chip-Seq_REH_Human0.83393928
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82886826
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82684569
133P53_22387025_ChIP-Seq_ESCs_Mouse0.82654164
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81943997
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80841128
136CBP_20019798_ChIP-Seq_JUKART_Human0.80473696
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80473696
138DPY_21335234_ChIP-Seq_ESCs_Mouse0.78989337
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.77587615
140NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76312347
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75813160
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75248576
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74233920
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74022647
145TET1_21451524_ChIP-Seq_MESCs_Mouse0.73534671
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72590579
147TP63_22573176_ChIP-Seq_HFKS_Human0.72486934
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72261751
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71609613
150TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.70856362
151UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70475415
152CTCF_20526341_ChIP-Seq_ESCs_Human0.69182465
153SA1_27219007_Chip-Seq_Bcells_Human0.67954192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder4.25400949
2MP0004043_abnormal_pH_regulation2.97441022
3MP0006072_abnormal_retinal_apoptosis2.91846754
4MP0002909_abnormal_adrenal_gland2.90136749
5MP0000013_abnormal_adipose_tissue2.83477165
6MP0001984_abnormal_olfaction2.80776905
7MP0004859_abnormal_synaptic_plasticity2.67675386
8* MP0005551_abnormal_eye_electrophysiolog2.63296851
9MP0002693_abnormal_pancreas_physiology2.57632568
10MP0002822_catalepsy2.57575954
11MP0002638_abnormal_pupillary_reflex2.46340057
12MP0005645_abnormal_hypothalamus_physiol2.43966156
13MP0003635_abnormal_synaptic_transmissio2.43057231
14MP0003880_abnormal_central_pattern2.34659570
15MP0001502_abnormal_circadian_rhythm2.29409165
16MP0003329_amyloid_beta_deposits2.26648493
17MP0000678_abnormal_parathyroid_gland2.25824919
18MP0001944_abnormal_pancreas_morphology2.22723193
19MP0004270_analgesia2.20643131
20MP0005646_abnormal_pituitary_gland2.14248298
21MP0005220_abnormal_exocrine_pancreas2.12894725
22MP0009780_abnormal_chondrocyte_physiolo2.11789713
23MP0003283_abnormal_digestive_organ2.04169967
24MP0003183_abnormal_peptide_metabolism2.04045996
25MP0003690_abnormal_glial_cell2.02265322
26MP0003879_abnormal_hair_cell2.01266516
27MP0002735_abnormal_chemical_nociception2.00540318
28MP0002272_abnormal_nervous_system1.99368134
29MP0002734_abnormal_mechanical_nocicepti1.95064279
30MP0005499_abnormal_olfactory_system1.94560300
31MP0005394_taste/olfaction_phenotype1.94560300
32MP0004885_abnormal_endolymph1.91003584
33MP0002063_abnormal_learning/memory/cond1.84983640
34MP0005253_abnormal_eye_physiology1.82927277
35MP0008789_abnormal_olfactory_epithelium1.82317537
36MP0009745_abnormal_behavioral_response1.77144356
37MP0003868_abnormal_feces_composition1.75993265
38MP0002064_seizures1.74324081
39MP0006276_abnormal_autonomic_nervous1.72422624
40MP0001188_hyperpigmentation1.71724274
41MP0002877_abnormal_melanocyte_morpholog1.68576461
42MP0002572_abnormal_emotion/affect_behav1.67732357
43MP0005379_endocrine/exocrine_gland_phen1.66942846
44MP0000920_abnormal_myelination1.65854403
45MP0006292_abnormal_olfactory_placode1.64393228
46MP0001501_abnormal_sleep_pattern1.64202946
47MP0000778_abnormal_nervous_system1.58725081
48MP0002837_dystrophic_cardiac_calcinosis1.56643572
49MP0001968_abnormal_touch/_nociception1.55364863
50MP0003787_abnormal_imprinting1.50840318
51MP0002090_abnormal_vision1.48521572
52MP0002184_abnormal_innervation1.47145239
53MP0002876_abnormal_thyroid_physiology1.46418809
54MP0002067_abnormal_sensory_capabilities1.45253127
55MP0005167_abnormal_blood-brain_barrier1.43450334
56MP0000003_abnormal_adipose_tissue1.42946702
57MP0001970_abnormal_pain_threshold1.42101846
58MP0001486_abnormal_startle_reflex1.40712218
59MP0002078_abnormal_glucose_homeostasis1.39411074
60MP0005423_abnormal_somatic_nervous1.38762316
61MP0000631_abnormal_neuroendocrine_gland1.38532581
62MP0003195_calcinosis1.36680758
63MP0003631_nervous_system_phenotype1.35291816
64MP0002557_abnormal_social/conspecific_i1.33693920
65MP0009046_muscle_twitch1.32732614
66MP0002653_abnormal_ependyma_morphology1.30116726
67MP0002736_abnormal_nociception_after1.28435131
68MP0003123_paternal_imprinting1.27826326
69MP0001905_abnormal_dopamine_level1.23863954
70MP0002733_abnormal_thermal_nociception1.21484403
71MP0001177_atelectasis1.18509454
72MP0002229_neurodegeneration1.18429306
73MP0003172_abnormal_lysosome_physiology1.18058918
74MP0001666_abnormal_nutrient_absorption1.16662703
75MP0002234_abnormal_pharynx_morphology1.14372210
76MP0005535_abnormal_body_temperature1.12997722
77MP0003632_abnormal_nervous_system1.12810572
78MP0003634_abnormal_glial_cell1.12244088
79MP0001440_abnormal_grooming_behavior1.10333738
80MP0008569_lethality_at_weaning1.10211190
81MP0003953_abnormal_hormone_level1.08583520
82MP0001963_abnormal_hearing_physiology1.08295230
83MP0001664_abnormal_digestion1.06976223
84MP0002882_abnormal_neuron_morphology1.05016328
85MP0002152_abnormal_brain_morphology1.04933362
86MP0000955_abnormal_spinal_cord1.03868030
87MP0005084_abnormal_gallbladder_morpholo1.00234033
88MP0004742_abnormal_vestibular_system0.97923391
89MP0001765_abnormal_ion_homeostasis0.97228590
90MP0001986_abnormal_taste_sensitivity0.95394911
91MP0000604_amyloidosis0.94229197
92MP0003122_maternal_imprinting0.93315053
93MP0004924_abnormal_behavior0.93278641
94MP0005386_behavior/neurological_phenoty0.93278641
95MP0004130_abnormal_muscle_cell0.93196393
96MP0008961_abnormal_basal_metabolism0.93098430
97MP0001661_extended_life_span0.87640858
98MP0004811_abnormal_neuron_physiology0.86838230
99MP0003137_abnormal_impulse_conducting0.86606828
100MP0002928_abnormal_bile_duct0.84646748
101MP0005310_abnormal_salivary_gland0.84136378
102MP0005195_abnormal_posterior_eye0.84118701
103MP0002752_abnormal_somatic_nervous0.83184261
104MP0002069_abnormal_eating/drinking_beha0.82497340
105MP0000751_myopathy0.82492555
106MP0005670_abnormal_white_adipose0.80146253
107MP0004858_abnormal_nervous_system0.79791566
108MP0001348_abnormal_lacrimal_gland0.78822844
109MP0003075_altered_response_to0.77168793
110MP0000681_abnormal_thyroid_gland0.76549427
111MP0002066_abnormal_motor_capabilities/c0.76231555
112MP0005365_abnormal_bile_salt0.75270234
113MP0001529_abnormal_vocalization0.74929643
114MP0000026_abnormal_inner_ear0.73724300
115MP0001485_abnormal_pinna_reflex0.72786940
116MP0002751_abnormal_autonomic_nervous0.72574289
117MP0000230_abnormal_systemic_arterial0.72527347
118MP0008872_abnormal_physiological_respon0.72362715
119MP0004085_abnormal_heartbeat0.72073074
120MP0008874_decreased_physiological_sensi0.72049667
121MP0004782_abnormal_surfactant_physiolog0.71713507
122MP0003633_abnormal_nervous_system0.71373437
123MP0005448_abnormal_energy_balance0.69957062
124MP0003959_abnormal_lean_body0.69824123
125MP0004145_abnormal_muscle_electrophysio0.69794745
126MP0001299_abnormal_eye_distance/0.68558119
127MP0000579_abnormal_nail_morphology0.68054843
128MP0008877_abnormal_DNA_methylation0.67685992
129MP0004142_abnormal_muscle_tone0.66552239
130MP0004147_increased_porphyrin_level0.57167373
131MP0002249_abnormal_larynx_morphology0.56351019
132MP0004215_abnormal_myocardial_fiber0.55651609
133MP0004510_myositis0.54337951
134MP0003045_fibrosis0.48028999
135MP0004133_heterotaxia0.47753261
136MP0001958_emphysema0.47272797
137MP0000639_abnormal_adrenal_gland0.46905622

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.90665952
2Action tremor (HP:0002345)4.52632506
3Abnormality of binocular vision (HP:0011514)4.36567041
4Diplopia (HP:0000651)4.36567041
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.31139892
6Obstructive sleep apnea (HP:0002870)4.20100153
7Neurofibrillary tangles (HP:0002185)4.04450601
8Limb dystonia (HP:0002451)4.02234691
9Abnormal eating behavior (HP:0100738)4.00671628
10Symptomatic seizures (HP:0011145)3.84519210
11Decreased circulating renin level (HP:0003351)3.84429829
12Hyperinsulinemic hypoglycemia (HP:0000825)3.82595812
13Hypoglycemic seizures (HP:0002173)3.68345315
14Epileptic encephalopathy (HP:0200134)3.65343125
15Abnormal rod and cone electroretinograms (HP:0008323)3.63793319
16Febrile seizures (HP:0002373)3.57385462
17Annular pancreas (HP:0001734)3.49079612
18Focal motor seizures (HP:0011153)3.44113035
19Torticollis (HP:0000473)3.37026350
20Central scotoma (HP:0000603)3.31219249
21Absence seizures (HP:0002121)3.27968630
22Visual hallucinations (HP:0002367)3.27198727
23Decreased central vision (HP:0007663)3.23677155
24Hypothermia (HP:0002045)3.22650541
25Abnormality of calcium-phosphate metabolism (HP:0100530)3.22631781
26Mutism (HP:0002300)3.21230755
27Spastic gait (HP:0002064)3.20505598
28Atonic seizures (HP:0010819)3.19945808
29Abnormality of macular pigmentation (HP:0008002)3.15615243
30EEG with generalized epileptiform discharges (HP:0011198)3.11403842
31Epileptiform EEG discharges (HP:0011182)3.10531319
32Pancreatic fibrosis (HP:0100732)3.09951130
33Medial flaring of the eyebrow (HP:0010747)3.09711653
34Cerebral inclusion bodies (HP:0100314)3.08756057
35Gait imbalance (HP:0002141)3.07998141
36Hemiplegia (HP:0002301)3.05480717
37Insulin-resistant diabetes mellitus (HP:0000831)3.04151226
38Congenital primary aphakia (HP:0007707)3.00831901
39Intention tremor (HP:0002080)2.99655210
40Sleep apnea (HP:0010535)2.99298025
41Hypoplasia of the fovea (HP:0007750)2.97184040
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.97184040
43Hemiparesis (HP:0001269)2.97090440
44Cerebral hypomyelination (HP:0006808)2.96206444
45Postural instability (HP:0002172)2.90096282
46Dialeptic seizures (HP:0011146)2.88545349
47Status epilepticus (HP:0002133)2.87327926
48Papilledema (HP:0001085)2.85812319
49Urinary bladder sphincter dysfunction (HP:0002839)2.85671001
50Bony spicule pigmentary retinopathy (HP:0007737)2.82767391
51Truncal ataxia (HP:0002078)2.81862634
52Dysmetria (HP:0001310)2.80707383
53Nephrogenic diabetes insipidus (HP:0009806)2.79049564
54Focal dystonia (HP:0004373)2.75440371
55Severe visual impairment (HP:0001141)2.73627502
56Generalized tonic-clonic seizures (HP:0002069)2.72740062
57Bundle branch block (HP:0011710)2.72308006
58Abnormality of the fovea (HP:0000493)2.69137914
59Akinesia (HP:0002304)2.68433954
60Tetraplegia (HP:0002445)2.64515575
61Gout (HP:0001997)2.61633454
62Abnormal pancreas size (HP:0012094)2.56964699
63Spastic tetraparesis (HP:0001285)2.55793124
64Craniofacial dystonia (HP:0012179)2.54254762
65Focal seizures (HP:0007359)2.52657852
66Bradykinesia (HP:0002067)2.52146184
67Cortical visual impairment (HP:0100704)2.49464122
68Hypsarrhythmia (HP:0002521)2.48890141
69True hermaphroditism (HP:0010459)2.47470748
70Osteomalacia (HP:0002749)2.45791729
71Polyphagia (HP:0002591)2.45765381
72Depression (HP:0000716)2.44277010
73Large for gestational age (HP:0001520)2.43962748
74Hypoglycemic coma (HP:0001325)2.43830850
75Dysdiadochokinesis (HP:0002075)2.41998009
76Poor eye contact (HP:0000817)2.41233376
77Genital tract atresia (HP:0001827)2.39222630
78Insomnia (HP:0100785)2.39102674
79Rigidity (HP:0002063)2.37367412
80Abnormality of endocrine pancreas physiology (HP:0012093)2.34495396
81Abnormality of the pancreatic islet cells (HP:0006476)2.34495396
82Neuronal loss in central nervous system (HP:0002529)2.33677703
83Turricephaly (HP:0000262)2.33512288
84Vaginal atresia (HP:0000148)2.33068299
85Abnormality of the corticospinal tract (HP:0002492)2.32571108
86Morphological abnormality of the pyramidal tract (HP:0002062)2.31343941
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31121506
88Impaired smooth pursuit (HP:0007772)2.30297516
89Hypokalemia (HP:0002900)2.29057546
90Delusions (HP:0000746)2.27377570
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25156335
92Abnormality of alanine metabolism (HP:0010916)2.25156335
93Hyperalaninemia (HP:0003348)2.25156335
94Congenital sensorineural hearing impairment (HP:0008527)2.24882624
95Clonus (HP:0002169)2.22938753
96Hyperglycemia (HP:0003074)2.21707362
97Chronic bronchitis (HP:0004469)2.20493029
98Ketoacidosis (HP:0001993)2.20425364
99Abnormality of the lower motor neuron (HP:0002366)2.19926592
100Ventricular fibrillation (HP:0001663)2.19832224
101Increased circulating renin level (HP:0000848)2.18516071
102Bronchomalacia (HP:0002780)2.17983154
103Chronic hepatic failure (HP:0100626)2.17905682
104Dysautonomia (HP:0002459)2.17565218
105Impaired vibration sensation in the lower limbs (HP:0002166)2.16982018
106Abnormality of renin-angiotensin system (HP:0000847)2.16804291
107Heart block (HP:0012722)2.14541600
108Spinal canal stenosis (HP:0003416)2.10630873
109Abnormality of midbrain morphology (HP:0002418)2.10094613
110Molar tooth sign on MRI (HP:0002419)2.10094613
111Lower limb muscle weakness (HP:0007340)2.09883495
112Rapidly progressive (HP:0003678)2.09293076
113Prolonged QT interval (HP:0001657)2.08980880
114Hyperphosphatemia (HP:0002905)2.08387388
115Poor coordination (HP:0002370)2.07345481
116Amblyopia (HP:0000646)2.04960311
117Broad-based gait (HP:0002136)2.04658067
118Pancreatic cysts (HP:0001737)2.04468286
119Abnormality of ocular smooth pursuit (HP:0000617)2.03989695
120Tubulointerstitial nephritis (HP:0001970)2.03939129
121Abnormal social behavior (HP:0012433)2.03234104
122Impaired social interactions (HP:0000735)2.03234104
123Menstrual irregularities (HP:0000858)2.02576054
124Progressive cerebellar ataxia (HP:0002073)2.02136333
125Type II diabetes mellitus (HP:0005978)2.01566751
126Abnormal atrioventricular conduction (HP:0005150)1.99415725
127Cystic liver disease (HP:0006706)1.98445729
128Stereotypic behavior (HP:0000733)1.97680082
129Hyperparathyroidism (HP:0000843)1.97262723
130Urinary urgency (HP:0000012)1.97010125
131Choreoathetosis (HP:0001266)1.95762032
132Aplasia/Hypoplasia of the lens (HP:0008063)1.95484459
133Abnormal protein glycosylation (HP:0012346)1.95303012
134Abnormal glycosylation (HP:0012345)1.95303012
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95303012
136Abnormal protein N-linked glycosylation (HP:0012347)1.95303012
137Retinitis pigmentosa (HP:0000510)1.94850223
138Apathy (HP:0000741)1.94190488
139Genetic anticipation (HP:0003743)1.93755566
140Abnormality of potassium homeostasis (HP:0011042)1.92597251
141Bifid tongue (HP:0010297)1.91689759
142Absent eyebrow (HP:0002223)1.91538795
143CNS hypomyelination (HP:0003429)1.91360305
144Generalized aminoaciduria (HP:0002909)1.90799318
145Aplasia/Hypoplasia of the macula (HP:0008059)1.90668563
146Limb hypertonia (HP:0002509)1.89880617
147Ankle clonus (HP:0011448)1.89460375
148Unsteady gait (HP:0002317)1.88756310
149Hyperactive renin-angiotensin system (HP:0000841)1.88662725
150Scotoma (HP:0000575)1.88030563
151Pancreatic islet-cell hyperplasia (HP:0004510)1.87748139
152Global brain atrophy (HP:0002283)1.87429460
153Peripheral hypomyelination (HP:0007182)1.87429109
154Retinal dysplasia (HP:0007973)1.86831421
155Hyperkalemia (HP:0002153)1.86513366
156Pheochromocytoma (HP:0002666)1.83378646
157Myokymia (HP:0002411)1.83310193
158Gaze-evoked nystagmus (HP:0000640)1.83180106
159Anxiety (HP:0000739)1.82625865
160Abnormal EKG (HP:0003115)1.82565540
161Agitation (HP:0000713)1.82354721
162Lower limb amyotrophy (HP:0007210)1.81964650
163Abnormal drinking behavior (HP:0030082)1.81720034
164Polydipsia (HP:0001959)1.81720034
165Attenuation of retinal blood vessels (HP:0007843)1.80412609
166Supranuclear gaze palsy (HP:0000605)1.80315703
167Neoplasm of the heart (HP:0100544)1.79338327
168Atelectasis (HP:0100750)1.79242321
169Syncope (HP:0001279)1.78928908
170Impaired vibratory sensation (HP:0002495)1.78897394
171Hyperventilation (HP:0002883)1.78709087
172Broad metatarsal (HP:0001783)1.74968070
173Diminished motivation (HP:0000745)1.73985829
174Distal upper limb amyotrophy (HP:0007149)1.73528329
175Upper limb amyotrophy (HP:0009129)1.73528329
176Nuclear cataract (HP:0100018)1.69066174
177Shallow orbits (HP:0000586)1.68625872
178Aplasia of the phalanges of the hand (HP:0009802)1.67607181
179Aplasia involving bones of the extremities (HP:0009825)1.67607181
180Aplasia involving bones of the upper limbs (HP:0009823)1.67607181
181Abnormality of the periventricular white matter (HP:0002518)1.66564781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.59565709
2MAPK153.85432499
3PRKD33.38054539
4AKT32.72252482
5NTRK32.67229717
6MAP2K72.54485512
7PASK2.44791442
8MAP3K42.26003477
9NTRK11.98614992
10EPHA41.85959718
11STK38L1.75972685
12MARK11.69384372
13FLT31.66527108
14IRAK31.61338922
15DAPK21.58273774
16DYRK1A1.54267087
17MINK11.52279805
18RIPK11.50861399
19MAP3K21.49337574
20PBK1.47514213
21CAMK11.44145311
22CASK1.40729066
23BRAF1.40552052
24NME11.39436209
25TAOK31.38844880
26BMPR21.35522265
27PRPF4B1.32608715
28HIPK21.31281947
29TYRO31.28417830
30CDC42BPA1.27248891
31PAK61.27232374
32STK381.23598757
33MAPK131.23180821
34PKN11.22609333
35SGK4941.17797012
36SGK2231.17797012
37ERBB31.17024755
38FRK1.16999573
39CAMKK21.16159263
40MAP3K91.11720223
41CAMK2D1.09220471
42SGK21.08505510
43IRAK11.05549202
44STK161.03407146
45PRKCE1.01771250
46CAMK2G1.00540735
47MAP2K60.99075803
48STK110.98164843
49CDK150.97863663
50MAPK120.97153840
51IRAK20.96880138
52ARAF0.96530863
53CDK30.95669543
54FGFR20.95424885
55PRKCG0.94831181
56WNK40.94265672
57CDK180.92549412
58FES0.92099923
59CDK50.91723778
60GRK50.90167614
61PRKD20.89538096
62CDK11A0.88175347
63PAK30.87510845
64PINK10.87488338
65FER0.85697979
66ERN10.84625989
67LATS20.81939351
68RIPK40.78667502
69PHKG20.78578263
70PHKG10.78578263
71NEK10.78367800
72PRKCH0.76104464
73OXSR10.75534919
74NTRK20.74831030
75MAP2K40.73733258
76MAPKAPK50.73635826
77CAMKK10.73131051
78SRPK10.68973153
79EPHA30.68963510
80ALK0.67680057
81DAPK10.67362475
82MAP3K10.67223458
83TNIK0.67099128
84DAPK30.66003709
85WNK30.65425013
86KSR20.64152182
87MAP3K110.63787169
88CAMK40.63630841
89TNK20.63281400
90CAMK2A0.63179054
91LMTK20.61710540
92CDK190.61034880
93TRIB30.60460021
94CAMK2B0.59223662
95ZAK0.58750611
96PDPK10.57773574
97PRKAA10.57572296
98RPS6KA20.57510042
99UHMK10.56714293
100RPS6KA30.56189516
101PDK10.56112042
102MARK20.56017357
103ERBB20.55825881
104SGK30.55601636
105ROCK10.55351467
106SIK20.55028874
107SGK10.55024930
108NEK60.55012985
109MAP3K130.54884597
110ROCK20.54164257
111MAP2K10.51458001
112EIF2AK30.51447216
113PLK20.51425507
114PTK2B0.51332281
115PRKCI0.51065685
116KSR10.50677707
117PRKG20.50425415
118PRKACA0.48605666
119GRK10.46097316
120CAMK1D0.45576620
121ADRBK20.45525724
122MAPK100.45041646
123LIMK10.44492640
124SIK30.44087560
125PRKCA0.42895459
126PTK20.42541382
127BRSK10.41297748
128TESK10.41213062
129MAP2K20.40832348
130MAPKAPK30.40762382
131CSNK1A10.40568219
132CDK140.40129923
133PRKCZ0.39574976
134PRKD10.38729121
135WNK10.38586241
136BRD40.38154735
137TIE10.36659796
138PRKCB0.36537514
139CAMK1G0.35885965
140MAPK80.35423509
141MAP3K70.34994257
142PRKG10.33851019

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.78756626
2Protein export_Homo sapiens_hsa030603.71323936
3Insulin secretion_Homo sapiens_hsa049113.41370994
4Synaptic vesicle cycle_Homo sapiens_hsa047213.27155127
5Nicotine addiction_Homo sapiens_hsa050332.97907571
6GABAergic synapse_Homo sapiens_hsa047272.56791034
7Morphine addiction_Homo sapiens_hsa050322.36169892
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31655082
9Collecting duct acid secretion_Homo sapiens_hsa049662.25156768
10Circadian entrainment_Homo sapiens_hsa047132.25055456
11Taste transduction_Homo sapiens_hsa047422.18119841
12Olfactory transduction_Homo sapiens_hsa047402.16106434
13Vibrio cholerae infection_Homo sapiens_hsa051102.06739203
14Circadian rhythm_Homo sapiens_hsa047102.02442299
15Pancreatic secretion_Homo sapiens_hsa049721.97096550
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81323981
17Cholinergic synapse_Homo sapiens_hsa047251.81128445
18Amphetamine addiction_Homo sapiens_hsa050311.78959422
19Type II diabetes mellitus_Homo sapiens_hsa049301.70812001
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70758201
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.69528825
22Dopaminergic synapse_Homo sapiens_hsa047281.69386273
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60106263
24Glutamatergic synapse_Homo sapiens_hsa047241.58773320
25Serotonergic synapse_Homo sapiens_hsa047261.58360217
26Cocaine addiction_Homo sapiens_hsa050301.55094401
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51824240
28Vitamin B6 metabolism_Homo sapiens_hsa007501.50024146
29Long-term potentiation_Homo sapiens_hsa047201.48685553
30Sulfur metabolism_Homo sapiens_hsa009201.29727244
31Renin secretion_Homo sapiens_hsa049241.27580187
32Salivary secretion_Homo sapiens_hsa049701.26589282
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24535187
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22609180
35Regulation of autophagy_Homo sapiens_hsa041401.19924779
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19834363
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19251509
38Bile secretion_Homo sapiens_hsa049761.18649699
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16047174
40N-Glycan biosynthesis_Homo sapiens_hsa005101.16025347
41Phototransduction_Homo sapiens_hsa047441.12996199
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09617621
43Type I diabetes mellitus_Homo sapiens_hsa049401.04568157
44Calcium signaling pathway_Homo sapiens_hsa040201.03578257
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.00410529
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96709934
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93786576
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93531161
49Thyroid hormone synthesis_Homo sapiens_hsa049180.93293804
50Oxytocin signaling pathway_Homo sapiens_hsa049210.91358433
51Axon guidance_Homo sapiens_hsa043600.90658399
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89770018
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.89076790
54Histidine metabolism_Homo sapiens_hsa003400.87776120
55Ether lipid metabolism_Homo sapiens_hsa005650.86341776
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85900107
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84439316
58Gastric acid secretion_Homo sapiens_hsa049710.82602876
59Inositol phosphate metabolism_Homo sapiens_hsa005620.82014545
60VEGF signaling pathway_Homo sapiens_hsa043700.80314738
61Lysosome_Homo sapiens_hsa041420.79498738
62Glucagon signaling pathway_Homo sapiens_hsa049220.79002926
63cAMP signaling pathway_Homo sapiens_hsa040240.77842820
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76720877
65Fatty acid biosynthesis_Homo sapiens_hsa000610.75800979
66Estrogen signaling pathway_Homo sapiens_hsa049150.70478379
67Glioma_Homo sapiens_hsa052140.70273447
68Long-term depression_Homo sapiens_hsa047300.69063092
69Fructose and mannose metabolism_Homo sapiens_hsa000510.68305672
70GnRH signaling pathway_Homo sapiens_hsa049120.65664865
71Ras signaling pathway_Homo sapiens_hsa040140.65009990
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62273069
73Rap1 signaling pathway_Homo sapiens_hsa040150.61788758
74Arginine biosynthesis_Homo sapiens_hsa002200.61576264
75Cardiac muscle contraction_Homo sapiens_hsa042600.60649112
76Arginine and proline metabolism_Homo sapiens_hsa003300.60641894
77Galactose metabolism_Homo sapiens_hsa000520.58713618
78Sphingolipid metabolism_Homo sapiens_hsa006000.57067196
79Nitrogen metabolism_Homo sapiens_hsa009100.55448416
80Choline metabolism in cancer_Homo sapiens_hsa052310.55230022
81Protein digestion and absorption_Homo sapiens_hsa049740.55072359
82Alcoholism_Homo sapiens_hsa050340.54787023
83Prolactin signaling pathway_Homo sapiens_hsa049170.53293811
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52157362
85Gap junction_Homo sapiens_hsa045400.50548241
86Oxidative phosphorylation_Homo sapiens_hsa001900.49940808
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.47118575
88Oocyte meiosis_Homo sapiens_hsa041140.46586596
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46435388
90Alzheimers disease_Homo sapiens_hsa050100.44615943
91Rheumatoid arthritis_Homo sapiens_hsa053230.44385894
92Endocytosis_Homo sapiens_hsa041440.44289720
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42708330
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.42503949
95Mineral absorption_Homo sapiens_hsa049780.41172273
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40465016
97beta-Alanine metabolism_Homo sapiens_hsa004100.39837518
98Melanogenesis_Homo sapiens_hsa049160.37734971
99Dilated cardiomyopathy_Homo sapiens_hsa054140.37690348
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.37487105
101Dorso-ventral axis formation_Homo sapiens_hsa043200.37405041
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37182060
103AMPK signaling pathway_Homo sapiens_hsa041520.36973653
104Other glycan degradation_Homo sapiens_hsa005110.36223452
105Folate biosynthesis_Homo sapiens_hsa007900.35630093
106Insulin signaling pathway_Homo sapiens_hsa049100.35306650
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.34598079
108Fat digestion and absorption_Homo sapiens_hsa049750.33700937
109Prion diseases_Homo sapiens_hsa050200.33300391
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33027493
111Tight junction_Homo sapiens_hsa045300.33000197
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.32099453
113mTOR signaling pathway_Homo sapiens_hsa041500.31662558
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31272281
115ErbB signaling pathway_Homo sapiens_hsa040120.30767139
116PPAR signaling pathway_Homo sapiens_hsa033200.29923507
117Glycerolipid metabolism_Homo sapiens_hsa005610.29593720
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29432368
119Arachidonic acid metabolism_Homo sapiens_hsa005900.28739955
120Insulin resistance_Homo sapiens_hsa049310.28698078
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28618255
122Fatty acid metabolism_Homo sapiens_hsa012120.27552886
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27092308
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26481012
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26290586
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26189132
127MAPK signaling pathway_Homo sapiens_hsa040100.25613820
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24862339
129Ovarian steroidogenesis_Homo sapiens_hsa049130.24675418
130ABC transporters_Homo sapiens_hsa020100.21093031
131Linoleic acid metabolism_Homo sapiens_hsa005910.20579783
132Purine metabolism_Homo sapiens_hsa002300.20477743

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