RGN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.65864970
2L-phenylalanine catabolic process (GO:0006559)7.65864970
3exogenous drug catabolic process (GO:0042738)7.40870476
4L-phenylalanine metabolic process (GO:0006558)7.29953790
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.29953790
6epoxygenase P450 pathway (GO:0019373)7.09702772
7aromatic amino acid family catabolic process (GO:0009074)6.87935956
8omega-hydroxylase P450 pathway (GO:0097267)6.75459835
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.38422388
10tryptophan catabolic process (GO:0006569)6.18158861
11indole-containing compound catabolic process (GO:0042436)6.18158861
12indolalkylamine catabolic process (GO:0046218)6.18158861
13kynurenine metabolic process (GO:0070189)6.06337512
14bile acid biosynthetic process (GO:0006699)5.99649138
15tryptophan metabolic process (GO:0006568)5.83004198
16glyoxylate metabolic process (GO:0046487)5.77224447
17alpha-linolenic acid metabolic process (GO:0036109)5.70413781
18urea metabolic process (GO:0019627)5.69754212
19urea cycle (GO:0000050)5.69754212
20negative regulation of fibrinolysis (GO:0051918)5.62062845
21high-density lipoprotein particle remodeling (GO:0034375)5.59268969
22regulation of fibrinolysis (GO:0051917)5.41324445
23cysteine metabolic process (GO:0006534)5.40426292
24protein carboxylation (GO:0018214)5.39061364
25peptidyl-glutamic acid carboxylation (GO:0017187)5.39061364
26sulfur amino acid catabolic process (GO:0000098)5.37133379
27complement activation, alternative pathway (GO:0006957)5.33244989
28regulation of protein activation cascade (GO:2000257)5.28435580
29nitrogen cycle metabolic process (GO:0071941)5.23767044
30serine family amino acid catabolic process (GO:0009071)5.16774027
31bile acid metabolic process (GO:0008206)5.15311491
32drug metabolic process (GO:0017144)5.10944771
33aromatic amino acid family metabolic process (GO:0009072)5.00036725
34regulation of complement activation (GO:0030449)4.92305692
35oxidative demethylation (GO:0070989)4.91769087
36ethanol metabolic process (GO:0006067)4.87630919
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87587972
38regulation of cholesterol esterification (GO:0010872)4.87112364
39tyrosine metabolic process (GO:0006570)4.85934203
40reverse cholesterol transport (GO:0043691)4.85588195
41regulation of triglyceride catabolic process (GO:0010896)4.81143677
42homocysteine metabolic process (GO:0050667)4.80693213
43plasma lipoprotein particle remodeling (GO:0034369)4.78122334
44protein-lipid complex remodeling (GO:0034368)4.78122334
45macromolecular complex remodeling (GO:0034367)4.78122334
46regulation of plasminogen activation (GO:0010755)4.75220842
47alpha-amino acid catabolic process (GO:1901606)4.68121639
48amino-acid betaine metabolic process (GO:0006577)4.63979585
49triglyceride homeostasis (GO:0070328)4.63484825
50acylglycerol homeostasis (GO:0055090)4.63484825
51negative regulation of cholesterol transport (GO:0032375)4.63388034
52negative regulation of sterol transport (GO:0032372)4.63388034
53lysine metabolic process (GO:0006553)4.61955964
54lysine catabolic process (GO:0006554)4.61955964
55phenylpropanoid metabolic process (GO:0009698)4.59559115
56phospholipid efflux (GO:0033700)4.57476443
57cellular ketone body metabolic process (GO:0046950)4.51438472
58bile acid and bile salt transport (GO:0015721)4.49446054
59glycine metabolic process (GO:0006544)4.49378817
60plasma lipoprotein particle clearance (GO:0034381)4.39729538
61indolalkylamine metabolic process (GO:0006586)4.38943931
62coenzyme catabolic process (GO:0009109)4.36891765
63imidazole-containing compound metabolic process (GO:0052803)4.36358416
64cellular glucuronidation (GO:0052695)4.35034314
65negative regulation of protein activation cascade (GO:2000258)4.33908452
66cellular amino acid catabolic process (GO:0009063)4.30172716
67cellular biogenic amine catabolic process (GO:0042402)4.30044384
68amine catabolic process (GO:0009310)4.30044384
69glutamate metabolic process (GO:0006536)4.24652375
70cholesterol efflux (GO:0033344)4.23898936
71serine family amino acid metabolic process (GO:0009069)4.22216839
72ethanol oxidation (GO:0006069)4.16430704
73S-adenosylmethionine metabolic process (GO:0046500)4.15902020
74negative regulation of hemostasis (GO:1900047)4.15419763
75negative regulation of blood coagulation (GO:0030195)4.15419763
76benzene-containing compound metabolic process (GO:0042537)4.14056037
77low-density lipoprotein particle remodeling (GO:0034374)4.09462373
78serine family amino acid biosynthetic process (GO:0009070)4.06871806
79dicarboxylic acid biosynthetic process (GO:0043650)4.06651151
80drug catabolic process (GO:0042737)4.05459860
81cellular modified amino acid catabolic process (GO:0042219)4.04966461
82aldehyde catabolic process (GO:0046185)4.03407053
83arginine metabolic process (GO:0006525)4.02656163
84intestinal cholesterol absorption (GO:0030299)4.01331181
85plasma lipoprotein particle assembly (GO:0034377)4.00844834
86fibrinolysis (GO:0042730)3.99271916
87regulation of humoral immune response (GO:0002920)3.95998852
88ketone body metabolic process (GO:1902224)3.90862699
89blood coagulation, intrinsic pathway (GO:0007597)3.86591801
90glucuronate metabolic process (GO:0019585)3.85764831
91uronic acid metabolic process (GO:0006063)3.85764831
92very-low-density lipoprotein particle assembly (GO:0034379)3.79471997
93negative regulation of coagulation (GO:0050819)3.79458746
94cofactor catabolic process (GO:0051187)3.78962387
95positive regulation of lipid catabolic process (GO:0050996)3.77945907
96carboxylic acid catabolic process (GO:0046395)3.77046211
97organic acid catabolic process (GO:0016054)3.77046211
98acute-phase response (GO:0006953)3.76723913
99regulation of bile acid biosynthetic process (GO:0070857)3.76443257
100phospholipid homeostasis (GO:0055091)3.76339387
101cholesterol homeostasis (GO:0042632)3.75434125
102positive regulation of triglyceride lipase activity (GO:0061365)3.75001720
103positive regulation of lipoprotein lipase activity (GO:0051006)3.75001720
104negative regulation of lipase activity (GO:0060192)3.74649482
105positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.74496826
106negative regulation of wound healing (GO:0061045)3.74258204
107complement activation, classical pathway (GO:0006958)3.74189148
108short-chain fatty acid metabolic process (GO:0046459)3.72552941
109complement activation (GO:0006956)3.72504979
110protein activation cascade (GO:0072376)3.71509779
111acetyl-CoA metabolic process (GO:0006084)3.70399825
112sterol homeostasis (GO:0055092)3.69269422
113plasma lipoprotein particle organization (GO:0071827)3.62678502
114regulation of cholesterol homeostasis (GO:2000188)3.61017285
115negative regulation of complement activation (GO:0045916)3.60318821
116cytolysis (GO:0019835)3.60307140
117protein-lipid complex assembly (GO:0065005)3.59415689
118alkaloid metabolic process (GO:0009820)3.59207163
119opsonization (GO:0008228)3.57076839
120NAD biosynthetic process (GO:0009435)3.54336429
121nicotinamide nucleotide biosynthetic process (GO:0019359)3.53173871
122heme transport (GO:0015886)3.52539133
123protein-lipid complex subunit organization (GO:0071825)3.52003749
124positive regulation of hemostasis (GO:1900048)3.41053601
125positive regulation of blood coagulation (GO:0030194)3.41053601
126sterol transport (GO:0015918)3.29648339
127cholesterol transport (GO:0030301)3.29648339
128flavonoid metabolic process (GO:0009812)3.20748926
129xenobiotic metabolic process (GO:0006805)3.17655024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.44209401
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22031329
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.09165716
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.54700279
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.27638251
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.14058620
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79570646
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04415551
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03566020
10GBX2_23144817_ChIP-Seq_PC3_Human2.17777423
11* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03616769
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9948273
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98065633
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95299445
15HTT_18923047_ChIP-ChIP_STHdh_Human1.61402384
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59133047
17CLOCK_20551151_ChIP-Seq_293T_Human1.54991870
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47311451
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.45292395
20GATA1_22025678_ChIP-Seq_K562_Human1.44435990
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40360587
22EZH2_22144423_ChIP-Seq_EOC_Human1.35475715
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24272077
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23942773
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20271055
26IGF1R_20145208_ChIP-Seq_DFB_Human1.20024382
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19793279
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19465579
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18942177
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17112535
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16998534
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.11584130
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10165382
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.07861026
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06306809
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05822247
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05680722
38REST_21632747_ChIP-Seq_MESCs_Mouse1.05392312
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04743360
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04557857
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.03000112
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01809174
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01794375
44SMAD4_21799915_ChIP-Seq_A2780_Human1.01006722
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00814879
46VDR_22108803_ChIP-Seq_LS180_Human1.00666538
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99359841
48TCF4_23295773_ChIP-Seq_U87_Human0.99019949
49STAT3_23295773_ChIP-Seq_U87_Human0.98935420
50CBP_20019798_ChIP-Seq_JUKART_Human0.97388525
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97388525
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96088038
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94719406
54ER_23166858_ChIP-Seq_MCF-7_Human0.94604664
55TCF4_22108803_ChIP-Seq_LS180_Human0.94544725
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94182914
57P300_19829295_ChIP-Seq_ESCs_Human0.93889896
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92936093
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92311819
60ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91624394
61AR_25329375_ChIP-Seq_VCAP_Human0.91557269
62SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91528714
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91442128
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90357922
65CRX_20693478_ChIP-Seq_RETINA_Mouse0.90249451
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89462254
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89052117
68NANOG_19829295_ChIP-Seq_ESCs_Human0.89034089
69SOX2_19829295_ChIP-Seq_ESCs_Human0.89034089
70REST_18959480_ChIP-ChIP_MESCs_Mouse0.88998204
71DROSHA_22980978_ChIP-Seq_HELA_Human0.88731873
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87378590
73TCF4_18268006_ChIP-ChIP_LS174T_Human0.87365859
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86820102
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86675853
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85744821
77AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85462255
78NANOG_18555785_Chip-Seq_ESCs_Mouse0.85047164
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84275438
80ZNF274_21170338_ChIP-Seq_K562_Hela0.83401451
81SMAD3_21741376_ChIP-Seq_EPCs_Human0.82802922
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.82644609
83KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82107229
84PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82000267
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81949688
86TP53_18474530_ChIP-ChIP_U2OS_Human0.81672427
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81428003
88GATA4_25053715_ChIP-Seq_YYC3_Human0.81218652
89MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81118644
90IRF8_22096565_ChIP-ChIP_GC-B_Human0.80877680
91* SMAD4_21741376_ChIP-Seq_EPCs_Human0.80807843
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.80005989
93P53_22387025_ChIP-Seq_ESCs_Mouse0.79385457
94OCT4_18555785_Chip-Seq_ESCs_Mouse0.79198178
95PHF8_20622853_ChIP-Seq_HELA_Human0.79159527
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.78830386
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78748810
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.78712792
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78620998
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77781825
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77092892
102ZNF263_19887448_ChIP-Seq_K562_Human0.75479195
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74217096
104RARA_24833708_ChIP-Seq_LIVER_Mouse0.73935986
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73295935
106* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72159574
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70496294
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68369404
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66548687
110NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65503764
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65503764
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.64011981
113RARB_24833708_ChIP-Seq_LIVER_Mouse0.63798543
114* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63788952
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.63495902
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60535537
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59830739
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59590213
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58991323
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58842151
121CEBPB_22108803_ChIP-Seq_LS180_Human0.57667426
122EGR1_19032775_ChIP-ChIP_M12_Human0.53694596
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.53599731
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52518064
125TAF15_26573619_Chip-Seq_HEK293_Human0.51730385
126AR_20517297_ChIP-Seq_VCAP_Human0.51684513
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51287106
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51213384
129MYC_19915707_ChIP-ChIP_AK7_Human0.51136604
130STAT1_17558387_ChIP-Seq_HELA_Human0.50540327
131CBP_21632823_ChIP-Seq_H3396_Human0.49421079
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48971945
133* ESET_19884257_ChIP-Seq_ESCs_Mouse0.48249611
134LXR_22292898_ChIP-Seq_THP-1_Human0.47619379
135PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46806594
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45021401
137* P53_21459846_ChIP-Seq_SAOS-2_Human0.44050888
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42761996
139GATA1_19941826_ChIP-Seq_K562_Human0.42560953
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.42402397
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.42354288
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42314124
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.42209269
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.41462161
145BCAT_22108803_ChIP-Seq_LS180_Human0.41174614
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.40669614
147ESR1_20079471_ChIP-ChIP_T-47D_Human0.40589014
148TAF2_19829295_ChIP-Seq_ESCs_Human0.40024907
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39960293
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.39923816
151GATA2_19941826_ChIP-Seq_K562_Human0.39365525
152ERG_21242973_ChIP-ChIP_JURKAT_Human0.38497627
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38132791
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37708942
155STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37135111
156LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36818037
157MYC_27129775_Chip-Seq_CORNEA_Mouse0.36388589
158* GATA6_25053715_ChIP-Seq_YYC3_Human0.35668883
159NCOR_22424771_ChIP-Seq_293T_Human0.34831759
160CDX2_22108803_ChIP-Seq_LS180_Human0.34579532
161SPI1_26923725_Chip-Seq_HPCs_Mouse0.34247936
162GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.33951785
163ERG_20517297_ChIP-Seq_VCAP_Human0.33710272
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.33485511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.41797721
2MP0005360_urolithiasis7.57420971
3MP0005085_abnormal_gallbladder_physiolo6.48523834
4MP0005365_abnormal_bile_salt6.18825959
5MP0008875_abnormal_xenobiotic_pharmacok5.22668689
6MP0003806_abnormal_nucleotide_metabolis4.31008130
7MP0003252_abnormal_bile_duct3.92620073
8MP0010329_abnormal_lipoprotein_level3.58969300
9MP0009840_abnormal_foam_cell3.25301773
10MP0005083_abnormal_biliary_tract3.09529530
11MP0003195_calcinosis2.82705710
12MP0005332_abnormal_amino_acid2.74273464
13MP0001666_abnormal_nutrient_absorption2.58464866
14MP0003191_abnormal_cellular_cholesterol2.19658042
15MP0004019_abnormal_vitamin_homeostasis2.14591943
16* MP0000609_abnormal_liver_physiology2.13321004
17MP0002118_abnormal_lipid_homeostasis2.10054043
18MP0002138_abnormal_hepatobiliary_system1.94578132
19MP0003868_abnormal_feces_composition1.92714080
20MP0005319_abnormal_enzyme/_coenzyme1.82270088
21MP0001764_abnormal_homeostasis1.67132555
22MP0009697_abnormal_copulation1.66605603
23MP0005584_abnormal_enzyme/coenzyme_acti1.56783023
24MP0005451_abnormal_body_composition1.50142734
25MP0002909_abnormal_adrenal_gland1.41998723
26MP0003011_delayed_dark_adaptation1.36614535
27MP0003879_abnormal_hair_cell1.27426234
28MP0003656_abnormal_erythrocyte_physiolo1.27115924
29MP0003186_abnormal_redox_activity1.27076384
30MP0003122_maternal_imprinting1.27061882
31MP0009643_abnormal_urine_homeostasis1.21371748
32MP0000598_abnormal_liver_morphology1.17250905
33MP0005647_abnormal_sex_gland1.13087053
34MP0003705_abnormal_hypodermis_morpholog1.11970386
35MP0009780_abnormal_chondrocyte_physiolo1.11778556
36MP0001984_abnormal_olfaction1.09731127
37MP0000604_amyloidosis1.07231182
38MP0009764_decreased_sensitivity_to1.04839504
39MP0009763_increased_sensitivity_to1.01855106
40MP0002254_reproductive_system_inflammat0.99441399
41MP0004270_analgesia0.95052936
42MP0010368_abnormal_lymphatic_system0.93581176
43MP0005551_abnormal_eye_electrophysiolog0.91670976
44MP0005636_abnormal_mineral_homeostasis0.90305327
45MP0005646_abnormal_pituitary_gland0.89696214
46MP0005408_hypopigmentation0.87897726
47MP0008469_abnormal_protein_level0.87122908
48MP0009642_abnormal_blood_homeostasis0.86239937
49MP0006036_abnormal_mitochondrial_physio0.82723243
50MP0005187_abnormal_penis_morphology0.80242987
51MP0010386_abnormal_urinary_bladder0.79812094
52MP0005376_homeostasis/metabolism_phenot0.79128360
53MP0009765_abnormal_xenobiotic_induced0.78876515
54MP0002078_abnormal_glucose_homeostasis0.77540691
55MP0000566_synostosis0.76918958
56MP0002876_abnormal_thyroid_physiology0.76213445
57MP0005084_abnormal_gallbladder_morpholo0.76106199
58MP0005670_abnormal_white_adipose0.75392075
59MP0002064_seizures0.73060798
60MP0005220_abnormal_exocrine_pancreas0.71753772
61MP0005379_endocrine/exocrine_gland_phen0.71473695
62MP0002971_abnormal_brown_adipose0.71083611
63MP0001661_extended_life_span0.69363827
64MP0002272_abnormal_nervous_system0.69127443
65MP0004043_abnormal_pH_regulation0.68866516
66MP0005334_abnormal_fat_pad0.68806077
67MP0004130_abnormal_muscle_cell0.68632353
68MP0009745_abnormal_behavioral_response0.68036350
69MP0003690_abnormal_glial_cell0.66553556
70MP0005535_abnormal_body_temperature0.66354690
71MP0001986_abnormal_taste_sensitivity0.65960847
72MP0003633_abnormal_nervous_system0.65271251
73MP0009053_abnormal_anal_canal0.64911888
74MP0005266_abnormal_metabolism0.64886098
75MP0003880_abnormal_central_pattern0.64659282
76MP0003329_amyloid_beta_deposits0.62219495
77MP0000639_abnormal_adrenal_gland0.61326176
78MP0001756_abnormal_urination0.57705111
79MP0006035_abnormal_mitochondrial_morpho0.57307329
80MP0003283_abnormal_digestive_organ0.56389825
81MP0009046_muscle_twitch0.55148780
82MP0005448_abnormal_energy_balance0.55094061
83MP0001915_intracranial_hemorrhage0.53633220
84MP0001944_abnormal_pancreas_morphology0.52934168
85MP0005386_behavior/neurological_phenoty0.52895524
86MP0004924_abnormal_behavior0.52895524
87MP0001486_abnormal_startle_reflex0.52611896
88MP0005464_abnormal_platelet_physiology0.52314613
89MP0000920_abnormal_myelination0.51786572
90MP0003718_maternal_effect0.50009979
91MP0003631_nervous_system_phenotype0.49555288
92MP0004142_abnormal_muscle_tone0.49513524
93MP0005395_other_phenotype0.49389578
94MP0002822_catalepsy0.49171937
95MP0006292_abnormal_olfactory_placode0.48183628
96MP0001440_abnormal_grooming_behavior0.48020760
97MP0001501_abnormal_sleep_pattern0.47480744
98MP0006276_abnormal_autonomic_nervous0.46891342
99MP0002282_abnormal_trachea_morphology0.46517178
100MP0002557_abnormal_social/conspecific_i0.46421844
101MP0008874_decreased_physiological_sensi0.46366868
102MP0005377_hearing/vestibular/ear_phenot0.46311345
103MP0003878_abnormal_ear_physiology0.46311345
104MP0003638_abnormal_response/metabolism_0.45564000
105MP0008873_increased_physiological_sensi0.45100621
106MP0002928_abnormal_bile_duct0.45057930
107MP0004782_abnormal_surfactant_physiolog0.44394709
108MP0002136_abnormal_kidney_physiology0.43522275
109MP0002837_dystrophic_cardiac_calcinosis0.43388570
110MP0003632_abnormal_nervous_system0.42570452
111MP0002638_abnormal_pupillary_reflex0.42442863
112MP0005167_abnormal_blood-brain_barrier0.41859582
113MP0005248_abnormal_Harderian_gland0.41116998
114MP0003953_abnormal_hormone_level0.40583408
115MP0003436_decreased_susceptibility_to0.40060795
116MP0003724_increased_susceptibility_to0.39435606
117MP0008872_abnormal_physiological_respon0.39290456
118MP0003075_altered_response_to0.38920768
119MP0009672_abnormal_birth_weight0.37925906
120MP0004381_abnormal_hair_follicle0.35581428
121MP0005166_decreased_susceptibility_to0.35205651
122MP0005666_abnormal_adipose_tissue0.34987321
123MP0000579_abnormal_nail_morphology0.33835862
124MP0009115_abnormal_fat_cell0.31953497
125MP0006082_CNS_inflammation0.31567356
126MP0000249_abnormal_blood_vessel0.31528000
127MP0001243_abnormal_dermal_layer0.31128472
128MP0000230_abnormal_systemic_arterial0.31054643
129MP0002796_impaired_skin_barrier0.30884886
130MP0002168_other_aberrant_phenotype0.30261363
131MP0001853_heart_inflammation0.30195801
132MP0004883_abnormal_blood_vessel0.29864472
133MP0002970_abnormal_white_adipose0.29708631
134MP0009384_cardiac_valve_regurgitation0.27991841
135MP0001881_abnormal_mammary_gland0.27047066
136MP0001845_abnormal_inflammatory_respons0.26608733
137MP0002090_abnormal_vision0.24264592
138MP0005164_abnormal_response_to0.23081208
139MP0002060_abnormal_skin_morphology0.22848304
140MP0002132_abnormal_respiratory_system0.22484395

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.51018142
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.45682346
3Intrahepatic cholestasis (HP:0001406)7.40187224
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.67947688
5Prolonged partial thromboplastin time (HP:0003645)6.61575522
6Hypobetalipoproteinemia (HP:0003563)6.55975570
7Xanthomatosis (HP:0000991)6.30359373
8Hyperlipoproteinemia (HP:0010980)5.62853424
9Complement deficiency (HP:0004431)5.27155431
10Hypolipoproteinemia (HP:0010981)4.84154656
11Joint hemorrhage (HP:0005261)4.82018442
12Hyperammonemia (HP:0001987)4.62493151
13Epidermoid cyst (HP:0200040)4.56782429
14Hyperglycinemia (HP:0002154)4.47945838
15Abnormality of the common coagulation pathway (HP:0010990)4.47418099
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.43794569
17Abnormality of methionine metabolism (HP:0010901)4.30693059
18Ketosis (HP:0001946)4.25894369
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.24674296
20Hypoalphalipoproteinemia (HP:0003233)4.16530874
21Fat malabsorption (HP:0002630)4.16349056
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13614926
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12455907
24Abnormality of serine family amino acid metabolism (HP:0010894)3.95101069
25Abnormality of glycine metabolism (HP:0010895)3.95101069
26Hyperglycinuria (HP:0003108)3.95093912
27Hypoglycemic coma (HP:0001325)3.88575655
28Abnormality of pyrimidine metabolism (HP:0004353)3.84770262
29Abnormality of complement system (HP:0005339)3.83959975
30Conjugated hyperbilirubinemia (HP:0002908)3.79758274
31Abnormality of the intrinsic pathway (HP:0010989)3.79460942
32Hypercholesterolemia (HP:0003124)3.69580951
33Hyperbilirubinemia (HP:0002904)3.40019329
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37726667
35Abnormality of fatty-acid metabolism (HP:0004359)3.33684750
36Delayed CNS myelination (HP:0002188)3.16339365
37Steatorrhea (HP:0002570)3.12514389
38Abnormality of serum amino acid levels (HP:0003112)3.11316785
39Abnormality of nucleobase metabolism (HP:0010932)3.04868128
40Ketoacidosis (HP:0001993)3.02971743
41Hepatocellular carcinoma (HP:0001402)2.99930628
42Spontaneous abortion (HP:0005268)2.99871752
43Hypochromic microcytic anemia (HP:0004840)2.98154806
44Myocardial infarction (HP:0001658)2.93671207
45Skin nodule (HP:0200036)2.81836160
46Metabolic acidosis (HP:0001942)2.76513849
47Acanthocytosis (HP:0001927)2.65656821
48Abnormality of purine metabolism (HP:0004352)2.64917061
49Systemic lupus erythematosus (HP:0002725)2.63756847
50Lethargy (HP:0001254)2.61202789
51Dicarboxylic aciduria (HP:0003215)2.58622568
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58622568
53Vascular calcification (HP:0004934)2.58173063
54Abnormal gallbladder morphology (HP:0012437)2.51626650
55Hypoglycemic seizures (HP:0002173)2.49730102
56Spastic diplegia (HP:0001264)2.48112955
57Glomerulonephritis (HP:0000099)2.47860430
58Cholelithiasis (HP:0001081)2.44100183
59Osteomalacia (HP:0002749)2.43493641
60Fair hair (HP:0002286)2.42197326
61Cerebral edema (HP:0002181)2.42160287
62Mitral stenosis (HP:0001718)2.39624640
63Abnormality of urine glucose concentration (HP:0011016)2.37894548
64Glycosuria (HP:0003076)2.37894548
65Gout (HP:0001997)2.37688401
66Cholecystitis (HP:0001082)2.36379744
67Abnormal gallbladder physiology (HP:0012438)2.36379744
68Irritability (HP:0000737)2.35652014
69Arthropathy (HP:0003040)2.32734286
70Neonatal onset (HP:0003623)2.32608031
71Cardiovascular calcification (HP:0011915)2.28762487
72Malnutrition (HP:0004395)2.27574466
73Recurrent gram-negative bacterial infections (HP:0005420)2.25238592
74Amyloidosis (HP:0011034)2.22715610
75Esophageal varix (HP:0002040)2.20701984
76Gingival bleeding (HP:0000225)2.18691193
77Menorrhagia (HP:0000132)2.15846848
78Neonatal hypoglycemia (HP:0001998)2.13992374
79Brushfield spots (HP:0001088)2.13013959
80Sensorimotor neuropathy (HP:0007141)2.12946728
81Pancreatitis (HP:0001733)2.11840665
82Hyperphosphaturia (HP:0003109)2.10896622
83Late onset (HP:0003584)2.09811843
84Poikilocytosis (HP:0004447)2.08847292
85Enlarged kidneys (HP:0000105)2.07016294
86Thrombophlebitis (HP:0004418)2.06651506
87Hypothermia (HP:0002045)2.04997328
88Vomiting (HP:0002013)2.04864099
89Hyperinsulinemic hypoglycemia (HP:0000825)2.02713088
90Abnormality of the gallbladder (HP:0005264)2.02561541
91Generalized aminoaciduria (HP:0002909)2.02347253
92Opisthotonus (HP:0002179)2.01006032
93Hemorrhage of the eye (HP:0011885)1.96505284
94Rickets (HP:0002748)1.93506875
95Retinal atrophy (HP:0001105)1.92960803
96Purpura (HP:0000979)1.92533271
97Pulmonary embolism (HP:0002204)1.91266934
98Atrioventricular block (HP:0001678)1.90119346
99Abnormal cartilage morphology (HP:0002763)1.89280670
100Renal cortical cysts (HP:0000803)1.87986447
101Abnormality of iron homeostasis (HP:0011031)1.87676501
102Proximal tubulopathy (HP:0000114)1.87011204
103Abnormality of transition element cation homeostasis (HP:0011030)1.85542506
104Hypophosphatemic rickets (HP:0004912)1.84065966
105Abnormality of proline metabolism (HP:0010907)1.83599351
106Hydroxyprolinuria (HP:0003080)1.83599351
107Abnormal enzyme/coenzyme activity (HP:0012379)1.80986049
108Elevated hepatic transaminases (HP:0002910)1.80376632
109Alkalosis (HP:0001948)1.80233052
110Status epilepticus (HP:0002133)1.78833676
111Joint swelling (HP:0001386)1.77942609
112Abnormality of vitamin metabolism (HP:0100508)1.77016191
113Nephritis (HP:0000123)1.74740018
114Hyperglycemia (HP:0003074)1.74032970
115Cerebral palsy (HP:0100021)1.68064144
116Reduced antithrombin III activity (HP:0001976)1.68014399
117Increased serum pyruvate (HP:0003542)1.67434828
118Blue irides (HP:0000635)1.62506466
119Generalized hypopigmentation of hair (HP:0011358)1.62086752
120Facial shape deformation (HP:0011334)1.59503968
121Potter facies (HP:0002009)1.59503968
122Abnormal urine phosphate concentration (HP:0012599)1.59475277
123Pancreatic islet-cell hyperplasia (HP:0004510)1.58668427
124Pigmentary retinal degeneration (HP:0001146)1.50530813
125Heart block (HP:0012722)1.49539060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.20760789
2SIK14.65824386
3FGFR44.55099600
4ERN14.14034104
5NTRK33.42749963
6TAOK33.13461172
7INSRR3.04716137
8BMPR1B2.99532997
9ERBB42.87809096
10WNK32.78009788
11PKN22.44551280
12MAP2K42.38037276
13CASK2.28586262
14MST1R2.14728807
15WNK42.07959478
16FLT32.06751158
17PHKG22.04289815
18PHKG12.04289815
19AKT31.92514523
20PIK3CG1.91088064
21MAPK111.86944710
22PDK21.85753670
23MARK11.83796251
24LATS11.75677191
25TRIB31.73861936
26TYK21.73007542
27MAP4K21.62281552
28DAPK21.56615752
29ABL21.53078286
30FRK1.46700028
31FGFR21.45263032
32PTK61.43744075
33NEK91.42074888
34OBSCN1.41761852
35STK391.39697814
36KDR1.29490522
37JAK21.23583812
38MAP3K71.19993014
39OXSR11.19605957
40PINK11.17800440
41CAMK2D1.15847098
42MAPK131.15410415
43PRKAA21.15307261
44MAP3K91.13758926
45MAP3K121.09870257
46MUSK1.05701580
47MAP2K31.03932375
48GRK61.02325142
49PRKCE1.01823464
50TBK11.01300395
51JAK11.00678388
52MAPK40.99810531
53ERBB20.98897693
54MAP3K140.98619000
55PRKG10.95922560
56MAP3K100.95413721
57PRKCZ0.93421800
58PRKACA0.92789219
59STK38L0.92516219
60MYLK0.89058201
61FER0.85881470
62MET0.85722396
63NTRK20.84527237
64CDK60.83061053
65LMTK20.82424453
66MAP3K30.81843172
67CAMK2B0.81055836
68MAPK150.79098754
69MAPK120.78324451
70CAMKK20.77807531
71NLK0.77367761
72PRKACG0.76854502
73ACVR1B0.76787678
74SGK10.76749538
75TIE10.74831265
76EPHB10.74346666
77CAMK2A0.74197855
78GRK50.73965079
79CSNK1D0.73747745
80MAP3K110.72345655
81CAMK1D0.70418045
82CSK0.70019597
83EPHA30.69920578
84CAMK2G0.68643914
85PRKAA10.68278625
86MAP2K60.66572889
87DYRK1B0.66298933
88GSK3A0.66206418
89DYRK20.65545365
90SGK30.64115512
91BCR0.62542286
92CDK50.60830402
93MAP3K40.60735079
94RPS6KA30.60452187
95IRAK30.60318342
96MAP3K20.60008118
97RIPK10.59857754
98FGFR30.58313861
99LIMK10.58123623
100MINK10.57250054
101ADRBK20.56897376
102MAPK70.56658371
103PRKACB0.56647873
104STK110.56015146
105CSF1R0.55752467
106MAPKAPK30.55142240
107TGFBR20.53968439
108TNK20.53944218
109CSNK1G10.53924997
110PTK20.53403516
111HIPK20.52955365
112PRKG20.52948644
113IKBKE0.52312090
114PRKCQ0.52164025
115PDPK10.50649107
116EPHA40.50574065
117DYRK1A0.49145878
118CSNK1A10.48197726
119PAK60.48130589
120TNIK0.46981809
121SGK20.46868104
122PRKCB0.46827123
123CAMK10.46647011
124MAP3K130.46212758
125RET0.46034875
126IGF1R0.45888155
127GRK10.45886313
128MAP3K50.45792717
129TAOK20.45311230
130MAP3K60.44351826
131CSNK1E0.43380549
132CDK40.43076264
133MAP2K10.41714678
134PRKCG0.40257905
135PBK0.38779579
136MTOR0.33679089
137PDK10.33324428
138CSNK1G20.33217374
139LATS20.33186707
140ICK0.32629803
141SGK2230.32448475
142SGK4940.32448475
143PKN10.32063846
144EGFR0.31592416
145CSNK1G30.29338774
146CAMK40.27977461
147PRKCA0.26042103
148IRAK20.26027405
149PDK30.25710537
150PDK40.25710537
151PIK3CA0.23772917
152MAP3K10.23450308
153ABL10.21883874
154IRAK10.21844571
155CAMK1G0.20937112
156PAK30.20574534

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.51245995
2Nitrogen metabolism_Homo sapiens_hsa009103.65413869
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38453512
4* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18410812
5Arginine biosynthesis_Homo sapiens_hsa002203.05621218
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75329181
7Complement and coagulation cascades_Homo sapiens_hsa046102.74642580
8Tryptophan metabolism_Homo sapiens_hsa003802.70451843
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63496202
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53155610
11Fatty acid degradation_Homo sapiens_hsa000712.49783523
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39655798
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30009143
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17745676
15Butanoate metabolism_Homo sapiens_hsa006502.16486208
16Peroxisome_Homo sapiens_hsa041462.07853874
17Chemical carcinogenesis_Homo sapiens_hsa052041.98571931
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.97931856
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96760561
20Propanoate metabolism_Homo sapiens_hsa006401.95473333
21Histidine metabolism_Homo sapiens_hsa003401.90958663
22PPAR signaling pathway_Homo sapiens_hsa033201.85663524
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.81975216
24Fatty acid metabolism_Homo sapiens_hsa012121.81820964
25Caffeine metabolism_Homo sapiens_hsa002321.80760995
26Staphylococcus aureus infection_Homo sapiens_hsa051501.75683179
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75122479
28Retinol metabolism_Homo sapiens_hsa008301.75065508
29beta-Alanine metabolism_Homo sapiens_hsa004101.73256665
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68604157
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61814483
32Selenocompound metabolism_Homo sapiens_hsa004501.58990710
33Phenylalanine metabolism_Homo sapiens_hsa003601.56650836
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50484124
35Bile secretion_Homo sapiens_hsa049761.50186324
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48792671
37Tyrosine metabolism_Homo sapiens_hsa003501.43884861
38Pyruvate metabolism_Homo sapiens_hsa006201.36976796
39Sulfur metabolism_Homo sapiens_hsa009201.35239810
40Fatty acid elongation_Homo sapiens_hsa000621.34593493
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.30735688
42Starch and sucrose metabolism_Homo sapiens_hsa005001.29678879
43Steroid biosynthesis_Homo sapiens_hsa001001.22094956
44ABC transporters_Homo sapiens_hsa020101.21080706
45Folate biosynthesis_Homo sapiens_hsa007901.19866552
46Biosynthesis of amino acids_Homo sapiens_hsa012301.19491442
47Fat digestion and absorption_Homo sapiens_hsa049751.15755025
48* Carbon metabolism_Homo sapiens_hsa012001.06961695
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02034082
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00202460
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.98752308
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.97820618
53Arginine and proline metabolism_Homo sapiens_hsa003300.96921841
54Vitamin B6 metabolism_Homo sapiens_hsa007500.94732827
55Sulfur relay system_Homo sapiens_hsa041220.92064467
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85118477
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84409965
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82501996
59Lysine degradation_Homo sapiens_hsa003100.81917441
60One carbon pool by folate_Homo sapiens_hsa006700.76526453
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70229128
62Glycerolipid metabolism_Homo sapiens_hsa005610.67982908
63Glutathione metabolism_Homo sapiens_hsa004800.63791055
64Fatty acid biosynthesis_Homo sapiens_hsa000610.55332353
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47562303
66* Metabolic pathways_Homo sapiens_hsa011000.45480435
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39730641
68Prion diseases_Homo sapiens_hsa050200.32988967
69Mineral absorption_Homo sapiens_hsa049780.32640223
70* Pentose phosphate pathway_Homo sapiens_hsa000300.30499490
71Insulin secretion_Homo sapiens_hsa049110.25912467
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25743689
73Galactose metabolism_Homo sapiens_hsa000520.24865903
74Linoleic acid metabolism_Homo sapiens_hsa005910.23957909
75Insulin resistance_Homo sapiens_hsa049310.22388243
76Fructose and mannose metabolism_Homo sapiens_hsa000510.22178029
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21357460
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.21300700
79Serotonergic synapse_Homo sapiens_hsa047260.19932000
80GABAergic synapse_Homo sapiens_hsa047270.16786892
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.15794458
82Circadian rhythm_Homo sapiens_hsa047100.15225364
83Pertussis_Homo sapiens_hsa051330.14162175
84Nicotine addiction_Homo sapiens_hsa050330.11042277
85Sphingolipid metabolism_Homo sapiens_hsa006000.10638781
86Glucagon signaling pathway_Homo sapiens_hsa049220.09235992
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08941306
88Other glycan degradation_Homo sapiens_hsa005110.06808780
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05518425
90Glutamatergic synapse_Homo sapiens_hsa047240.04897442
91Amphetamine addiction_Homo sapiens_hsa050310.02509124
92AMPK signaling pathway_Homo sapiens_hsa041520.01506923
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.00894134
94Amoebiasis_Homo sapiens_hsa05146-0.2481971
95Ether lipid metabolism_Homo sapiens_hsa00565-0.2431326
96Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2394525
97Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2331615
98Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2292143
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2050218
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1997717
101Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1995363
102Renin-angiotensin system_Homo sapiens_hsa04614-0.1948845
103Hepatitis C_Homo sapiens_hsa05160-0.1895361
104Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1690824
105Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1656811
106Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1579191
107African trypanosomiasis_Homo sapiens_hsa05143-0.1538846
108Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1483747
109Regulation of autophagy_Homo sapiens_hsa04140-0.1300541
110Insulin signaling pathway_Homo sapiens_hsa04910-0.1015403
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0964985
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0834122
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0571480
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0494743
115Type II diabetes mellitus_Homo sapiens_hsa04930-0.0255300
116Pancreatic secretion_Homo sapiens_hsa04972-0.0204004
117Cocaine addiction_Homo sapiens_hsa05030-0.0135893

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