RGMA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)6.07405554
2presynaptic membrane assembly (GO:0097105)5.11815242
3proline biosynthetic process (GO:0006561)5.08668459
4transcription from mitochondrial promoter (GO:0006390)5.00688791
5presynaptic membrane organization (GO:0097090)4.88813512
6axon ensheathment in central nervous system (GO:0032291)4.88261002
7central nervous system myelination (GO:0022010)4.88261002
8establishment of apical/basal cell polarity (GO:0035089)4.70428155
9neuron cell-cell adhesion (GO:0007158)4.51655894
10establishment or maintenance of monopolar cell polarity (GO:0061339)4.40088163
11establishment of monopolar cell polarity (GO:0061162)4.40088163
12lateral sprouting from an epithelium (GO:0060601)4.20495614
13cell migration in hindbrain (GO:0021535)4.04760272
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02426024
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.94876341
16convergent extension (GO:0060026)3.94371638
17nucleobase catabolic process (GO:0046113)3.82195097
18histone H4-K12 acetylation (GO:0043983)3.79773222
19axonal fasciculation (GO:0007413)3.75161811
20vocalization behavior (GO:0071625)3.73130862
21auditory behavior (GO:0031223)3.67722086
22spinal cord development (GO:0021510)3.66064098
23neuron recognition (GO:0008038)3.63684668
24somite rostral/caudal axis specification (GO:0032525)3.61344953
25embryonic process involved in female pregnancy (GO:0060136)3.60456536
26neuronal action potential propagation (GO:0019227)3.59405095
27transmission of nerve impulse (GO:0019226)3.56047630
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.55650055
29negative regulation of Ras GTPase activity (GO:0034261)3.55331267
30proline metabolic process (GO:0006560)3.52024668
31regulation of synapse structural plasticity (GO:0051823)3.50580893
32positive regulation of protein homooligomerization (GO:0032464)3.50499560
33replication fork processing (GO:0031297)3.50394292
34embryonic camera-type eye development (GO:0031076)3.44770338
35neuronal stem cell maintenance (GO:0097150)3.43776518
36dermatan sulfate biosynthetic process (GO:0030208)3.43620757
37planar cell polarity pathway involved in neural tube closure (GO:0090179)3.41613285
38regulation of protein homooligomerization (GO:0032462)3.39080154
39exploration behavior (GO:0035640)3.38389563
40regulation of integrin activation (GO:0033623)3.37364019
41histone H4-K5 acetylation (GO:0043981)3.34600325
42histone H4-K8 acetylation (GO:0043982)3.34600325
43negative regulation of glial cell proliferation (GO:0060253)3.34262544
44response to auditory stimulus (GO:0010996)3.32480647
45mitochondrion transport along microtubule (GO:0047497)3.30633262
46establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.30633262
47negative regulation of catenin import into nucleus (GO:0035414)3.28624619
48astrocyte differentiation (GO:0048708)3.28326871
49negative regulation of JAK-STAT cascade (GO:0046426)3.27484867
50oxidative demethylation (GO:0070989)3.26363301
51protein localization to synapse (GO:0035418)3.23968759
52cellular potassium ion homeostasis (GO:0030007)3.20875256
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19987264
54regulation of hippo signaling (GO:0035330)3.18649165
55mechanosensory behavior (GO:0007638)3.17974717
56regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.16807986
57negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.15883924
58notochord development (GO:0030903)3.15067101
59potassium ion import (GO:0010107)3.14396337
60regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14210571
61pre-miRNA processing (GO:0031054)3.13862237
62dermatan sulfate metabolic process (GO:0030205)3.11795237
63intracellular estrogen receptor signaling pathway (GO:0030520)3.10682790
64primitive streak formation (GO:0090009)3.10526854
65gamma-aminobutyric acid transport (GO:0015812)3.10471770
66neuromuscular synaptic transmission (GO:0007274)3.09526342
67negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09023803
68embryonic placenta development (GO:0001892)3.07654594
69synaptic transmission, glutamatergic (GO:0035249)3.07493304
70head development (GO:0060322)3.06087253
71regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.05750713
72positive regulation of synapse assembly (GO:0051965)3.04431620
73negative regulation of epidermis development (GO:0045683)3.04365534
74mitochondrial DNA metabolic process (GO:0032042)3.04189937
75regulation of neurotransmitter uptake (GO:0051580)3.03925300
76regulation of glutamate receptor signaling pathway (GO:1900449)3.01310089
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.00689658
78establishment of mitochondrion localization (GO:0051654)3.00200436
79negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.99728630
80glial cell migration (GO:0008347)2.98231588
81neurotransmitter-gated ion channel clustering (GO:0072578)2.98148225
82negative regulation of chondrocyte differentiation (GO:0032331)2.97885188
83regulation of respiratory system process (GO:0044065)2.96958872
84branching involved in mammary gland duct morphogenesis (GO:0060444)2.96270040
85polarized epithelial cell differentiation (GO:0030859)2.95560611
86layer formation in cerebral cortex (GO:0021819)2.95075433
87negative regulation of potassium ion transmembrane transport (GO:1901380)2.93954795
88behavioral response to nicotine (GO:0035095)2.93291691
89positive regulation of developmental pigmentation (GO:0048087)2.91671758
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90407272
91apoptotic process involved in morphogenesis (GO:0060561)2.89534158
92anatomical structure regression (GO:0060033)2.89051231
93regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.88890275
94face development (GO:0060324)2.88778389
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87849741
96glutamate receptor signaling pathway (GO:0007215)2.87827390
97establishment of nucleus localization (GO:0040023)2.86019401
98paraxial mesoderm development (GO:0048339)2.85470809
99synapse assembly (GO:0007416)2.82624592
100retinoic acid receptor signaling pathway (GO:0048384)2.82603017
101cerebellar granule cell differentiation (GO:0021707)2.82386264
102forebrain neuron differentiation (GO:0021879)2.81663608
103cellular response to cholesterol (GO:0071397)2.80791485
104proline transport (GO:0015824)2.80248754
105limb development (GO:0060173)2.80116578
106appendage development (GO:0048736)2.80116578
107anterior/posterior axis specification, embryo (GO:0008595)2.79335768
108L-amino acid import (GO:0043092)2.79208601
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77959004
110negative regulation of oligodendrocyte differentiation (GO:0048715)2.77209137
111negative regulation of smoothened signaling pathway (GO:0045879)2.76272647
112negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.76169368
113retinal ganglion cell axon guidance (GO:0031290)2.75656369
114bone morphogenesis (GO:0060349)2.75613077
115innervation (GO:0060384)2.75447380
116ventricular trabecula myocardium morphogenesis (GO:0003222)2.75418016
117proximal/distal pattern formation (GO:0009954)2.74235044
118dendrite morphogenesis (GO:0048813)2.74167604
119regulation of cAMP-dependent protein kinase activity (GO:2000479)2.73167545
120regulation of response to osmotic stress (GO:0047484)2.72486175
121regulation of mammary gland epithelial cell proliferation (GO:0033599)2.71012448
122neuronal ion channel clustering (GO:0045161)2.69742811
123regulation of cilium movement (GO:0003352)2.69453508
124negative regulation of cell cycle arrest (GO:0071157)2.69208456
125hypotonic response (GO:0006971)2.69195712
126neurotransmitter catabolic process (GO:0042135)2.67263869
127synaptic vesicle endocytosis (GO:0048488)2.66930846
128positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66139280
129cochlea morphogenesis (GO:0090103)2.65002969
130trophectodermal cell differentiation (GO:0001829)2.64969021
131polyketide metabolic process (GO:0030638)2.64534339
132doxorubicin metabolic process (GO:0044598)2.64534339
133daunorubicin metabolic process (GO:0044597)2.64534339
134cranial nerve development (GO:0021545)2.63953883
135synaptic vesicle docking involved in exocytosis (GO:0016081)2.63211100
136dendritic spine morphogenesis (GO:0060997)2.62582309
137eye photoreceptor cell differentiation (GO:0001754)2.61654172
138photoreceptor cell differentiation (GO:0046530)2.61654172
139membrane depolarization during action potential (GO:0086010)2.60552297
140negative regulation of protein oligomerization (GO:0032460)2.60387688
141DNA strand renaturation (GO:0000733)2.60342488
142synapse organization (GO:0050808)2.60230337
143establishment or maintenance of apical/basal cell polarity (GO:0035088)2.60021379
144establishment or maintenance of bipolar cell polarity (GO:0061245)2.60021379
145regulation of synapse assembly (GO:0051963)2.59668103
146synaptic vesicle maturation (GO:0016188)2.59332330
147central nervous system projection neuron axonogenesis (GO:0021952)2.59095362
148nonmotile primary cilium assembly (GO:0035058)2.58426496
149negative regulation of cartilage development (GO:0061037)2.58231863
150cerebral cortex radially oriented cell migration (GO:0021799)2.58027374
151DNA demethylation (GO:0080111)2.57850029
152negative regulation of axon extension (GO:0030517)2.56772412
153sodium ion export (GO:0071436)2.56351082
154startle response (GO:0001964)2.56324755
155Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55838681
156non-canonical Wnt signaling pathway (GO:0035567)2.55510333
157regulation of neuronal synaptic plasticity (GO:0048168)2.54809580
158potassium ion homeostasis (GO:0055075)2.54556136
159nodal signaling pathway (GO:0038092)2.54062974
160regulation of synaptic transmission, glutamatergic (GO:0051966)2.54000118
161cochlea development (GO:0090102)2.53255827
162neuron-neuron synaptic transmission (GO:0007270)2.53233938
163negative regulation of glial cell differentiation (GO:0045686)2.53061549
164pyrimidine nucleobase catabolic process (GO:0006208)2.52866521
165negative regulation of axonogenesis (GO:0050771)2.52119269
166astrocyte development (GO:0014002)2.52068374
167collecting duct development (GO:0072044)2.51562415
168adult walking behavior (GO:0007628)2.51230324
169histone arginine methylation (GO:0034969)2.50775208
170maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.49795785
171neurotransmitter uptake (GO:0001504)2.49416023
172maintenance of protein location in nucleus (GO:0051457)2.48917287
173negative regulation of synaptic transmission, GABAergic (GO:0032229)2.48650520
174regulation of synaptic vesicle exocytosis (GO:2000300)2.48387921
175establishment of tissue polarity (GO:0007164)2.48364926
176establishment of planar polarity (GO:0001736)2.48364926
177cellular response to sterol (GO:0036315)2.47627542
178negative regulation of astrocyte differentiation (GO:0048712)2.47444531
179histone H4-K16 acetylation (GO:0043984)2.47031271
180regulation of axon guidance (GO:1902667)2.46803779
181epithelial cell fate commitment (GO:0072148)2.46576603
182amino acid import (GO:0043090)2.46317630
183locomotory exploration behavior (GO:0035641)2.45971002
184positive regulation of potassium ion transmembrane transport (GO:1901381)2.45797977
185cell communication by electrical coupling (GO:0010644)2.45146417
186regulation of establishment of planar polarity (GO:0090175)2.44469134
187regulation of axon extension involved in axon guidance (GO:0048841)2.43605320
188RNA localization (GO:0006403)2.42379304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.02887122
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.02887122
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.02887122
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.57246591
5* SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.47278387
6SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.95022441
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.92272235
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.91013980
9GBX2_23144817_ChIP-Seq_PC3_Human2.85287426
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.74946568
11* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.68062332
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.61544717
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55056897
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.52114152
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.47126438
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45226035
17* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40618196
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.39882418
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.35756510
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32863511
21ZFP281_27345836_Chip-Seq_ESCs_Mouse2.32487823
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.21146013
23* CBX2_27304074_Chip-Seq_ESCs_Mouse2.18773841
24* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.18629113
25POU5F1_16518401_ChIP-PET_MESCs_Mouse2.15144575
26DROSHA_22980978_ChIP-Seq_HELA_Human2.12997136
27* GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04895562
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04153604
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03603437
30LXR_22292898_ChIP-Seq_THP-1_Human2.02273769
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.01605870
32TCF3_18692474_ChIP-Seq_MEFs_Mouse2.00680633
33* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.00227242
34KDM2B_26808549_Chip-Seq_K562_Human1.94698569
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92464421
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.91831245
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91494324
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.79933786
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79341051
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78961661
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78796643
42* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77911846
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77890931
44* RING1B_27294783_Chip-Seq_NPCs_Mouse1.76041913
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62826553
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62716799
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62620105
48AR_21572438_ChIP-Seq_LNCaP_Human1.60244908
49IGF1R_20145208_ChIP-Seq_DFB_Human1.59209705
50RNF2_27304074_Chip-Seq_NSC_Mouse1.58790853
51* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57651297
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53737037
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53509778
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52097788
55* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.51770431
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50159754
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48957461
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48491207
59* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.45174494
60* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44575218
61* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42481859
62NANOG_21062744_ChIP-ChIP_HESCs_Human1.42279242
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.41284288
64* RNF2_27304074_Chip-Seq_ESCs_Mouse1.40361672
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39347228
66* KDM2B_26808549_Chip-Seq_DND41_Human1.38891834
67* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37034726
68* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37034726
69NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36930390
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33250983
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33250983
72RACK7_27058665_Chip-Seq_MCF-7_Human1.33125823
73* RING1B_27294783_Chip-Seq_ESCs_Mouse1.32693492
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.32518730
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29908416
76* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28027618
77* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27423275
78ZNF274_21170338_ChIP-Seq_K562_Hela1.26491355
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26490583
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.26471460
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.24575583
82* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24208313
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.24045832
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23765794
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.23451089
86VDR_22108803_ChIP-Seq_LS180_Human1.23404542
87* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21139555
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20994621
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20190324
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20061902
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19644438
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18690217
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18645346
94* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.18146239
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17543186
96* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17492919
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.17441572
98P300_19829295_ChIP-Seq_ESCs_Human1.17061656
99EZH2_22144423_ChIP-Seq_EOC_Human1.16573476
100SMC4_20622854_ChIP-Seq_HELA_Human1.15963211
101RARB_27405468_Chip-Seq_BRAIN_Mouse1.15794107
102* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15760359
103CTCF_27219007_Chip-Seq_Bcells_Human1.15679400
104* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15566320
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13580466
106SMAD4_21799915_ChIP-Seq_A2780_Human1.13370494
107* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12612343
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12361569
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.11949515
110* SMAD3_21741376_ChIP-Seq_EPCs_Human1.11672419
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10917173
112TET1_21490601_ChIP-Seq_MESCs_Mouse1.10712211
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10480837
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10204649
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.10132408
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09710136
117REST_21632747_ChIP-Seq_MESCs_Mouse1.09584833
118TAF15_26573619_Chip-Seq_HEK293_Human1.09419962
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09058026
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09012873
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08381424
122TET1_21451524_ChIP-Seq_MESCs_Mouse1.07305111
123AR_19668381_ChIP-Seq_PC3_Human1.07294557
124TP53_22127205_ChIP-Seq_IMR90_Human1.06617661
125ELK3_25401928_ChIP-Seq_HUVEC_Human1.06545243
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06352285
127JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06017427
128* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05606014
129SMAD3_21741376_ChIP-Seq_ESCs_Human1.05393735
130* NANOG_16518401_ChIP-PET_MESCs_Mouse1.04896631
131* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04474353
132PIAS1_25552417_ChIP-Seq_VCAP_Human1.03934207
133GATA1_26923725_Chip-Seq_HPCs_Mouse1.03721215
134HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03416587
135* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03222500
136* TP53_23651856_ChIP-Seq_MEFs_Mouse1.02821976
137OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02520606
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01860933
139SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01766351
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01722405
141NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01266975
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01157479
143* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01048315
144* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00878330
145STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00665828
146* CREB1_26743006_Chip-Seq_LNCaP_Human1.00187975
147P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00176416
148* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00039979
149* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99998554
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99084085
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98969641
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98787043
153* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98256808
154SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97272671
155ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97067670
156* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96833143
157SOX3_22085726_ChIP-Seq_NPCs_Mouse0.96764187
158ISL1_27105846_Chip-Seq_CPCs_Mouse0.96362773
159AR_25329375_ChIP-Seq_VCAP_Human0.94558593
160STAT3_23295773_ChIP-Seq_U87_Human0.92292388
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91591357
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.91543097
163* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91516647
164* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90613346
165CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90167242
166* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87814031
167TCF4_23295773_ChIP-Seq_U87_Human0.87295949
168TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85391708
169SMAD3_21741376_ChIP-Seq_HESCs_Human0.85370838
170AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83365264
171SOX9_26525672_Chip-Seq_HEART_Mouse0.82830094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.49084220
2MP0003136_yellow_coat_color4.06637384
3MP0002653_abnormal_ependyma_morphology3.27981993
4MP0003880_abnormal_central_pattern3.06019942
5MP0003283_abnormal_digestive_organ2.92023505
6MP0003890_abnormal_embryonic-extraembry2.67325440
7MP0004858_abnormal_nervous_system2.52913695
8MP0002249_abnormal_larynx_morphology2.36232721
9MP0003122_maternal_imprinting2.31741311
10MP0008057_abnormal_DNA_replication2.31436561
11MP0004233_abnormal_muscle_weight2.30438990
12MP0001984_abnormal_olfaction2.17935973
13MP0001486_abnormal_startle_reflex2.12378725
14MP0002064_seizures2.11594016
15MP0000778_abnormal_nervous_system2.11032639
16MP0009745_abnormal_behavioral_response2.06214513
17MP0004133_heterotaxia2.04433435
18MP0005171_absent_coat_pigmentation2.03580257
19MP0004859_abnormal_synaptic_plasticity2.01258726
20MP0002734_abnormal_mechanical_nocicepti1.98882298
21MP0002272_abnormal_nervous_system1.94259376
22MP0003119_abnormal_digestive_system1.93553504
23MP0009278_abnormal_bone_marrow1.88206102
24MP0006276_abnormal_autonomic_nervous1.85624922
25MP0004145_abnormal_muscle_electrophysio1.84204143
26MP0003137_abnormal_impulse_conducting1.82630661
27MP0005499_abnormal_olfactory_system1.82299616
28MP0005394_taste/olfaction_phenotype1.82299616
29MP0001502_abnormal_circadian_rhythm1.81589019
30MP0006292_abnormal_olfactory_placode1.80879348
31MP0002932_abnormal_joint_morphology1.79236003
32MP0000049_abnormal_middle_ear1.77862186
33MP0003705_abnormal_hypodermis_morpholog1.71625038
34MP0001968_abnormal_touch/_nociception1.67746216
35MP0002638_abnormal_pupillary_reflex1.66088018
36MP0002822_catalepsy1.64780699
37MP0002735_abnormal_chemical_nociception1.63422868
38MP0000579_abnormal_nail_morphology1.60955632
39MP0000762_abnormal_tongue_morphology1.60754248
40MP0001293_anophthalmia1.59254227
41MP0001970_abnormal_pain_threshold1.58403221
42MP0002557_abnormal_social/conspecific_i1.58316444
43MP0001485_abnormal_pinna_reflex1.58243422
44MP0005623_abnormal_meninges_morphology1.58178622
45MP0003755_abnormal_palate_morphology1.55784482
46MP0002736_abnormal_nociception_after1.52963080
47MP0005646_abnormal_pituitary_gland1.51452340
48MP0000955_abnormal_spinal_cord1.50967630
49MP0002282_abnormal_trachea_morphology1.50316540
50MP0000026_abnormal_inner_ear1.45575322
51MP0003938_abnormal_ear_development1.44497752
52MP0004142_abnormal_muscle_tone1.44392808
53MP0002067_abnormal_sensory_capabilities1.44353046
54MP0008961_abnormal_basal_metabolism1.43626045
55MP0004264_abnormal_extraembryonic_tissu1.41541309
56MP0001529_abnormal_vocalization1.40416373
57MP0003329_amyloid_beta_deposits1.39273248
58MP0008995_early_reproductive_senescence1.35077019
59MP0002084_abnormal_developmental_patter1.34778756
60MP0003935_abnormal_craniofacial_develop1.34708803
61* MP0002116_abnormal_craniofacial_bone1.33483405
62MP0005551_abnormal_eye_electrophysiolog1.31958221
63MP0005423_abnormal_somatic_nervous1.31475778
64MP0005248_abnormal_Harderian_gland1.28119054
65MP0003787_abnormal_imprinting1.27636840
66MP0002114_abnormal_axial_skeleton1.24742292
67* MP0003861_abnormal_nervous_system1.22801706
68MP0008569_lethality_at_weaning1.21621029
69MP0002254_reproductive_system_inflammat1.21614499
70MP0002063_abnormal_learning/memory/cond1.21004044
71MP0003385_abnormal_body_wall1.20967613
72MP0005508_abnormal_skeleton_morphology1.20866429
73MP0003646_muscle_fatigue1.20761624
74* MP0002085_abnormal_embryonic_tissue1.20532799
75MP0000428_abnormal_craniofacial_morphol1.20392284
76MP0003690_abnormal_glial_cell1.19364318
77MP0002332_abnormal_exercise_endurance1.18238695
78MP0003942_abnormal_urinary_system1.17674913
79MP0006072_abnormal_retinal_apoptosis1.17277023
80MP0003878_abnormal_ear_physiology1.16735127
81MP0005377_hearing/vestibular/ear_phenot1.16735127
82MP0004130_abnormal_muscle_cell1.16117818
83MP0002752_abnormal_somatic_nervous1.15696695
84MP0000751_myopathy1.15641157
85MP0001963_abnormal_hearing_physiology1.15169397
86MP0005076_abnormal_cell_differentiation1.13611779
87MP0001440_abnormal_grooming_behavior1.12729167
88MP0005167_abnormal_blood-brain_barrier1.12245364
89MP0001849_ear_inflammation1.11719735
90MP0000432_abnormal_head_morphology1.10273105
91MP0001348_abnormal_lacrimal_gland1.08063027
92MP0000678_abnormal_parathyroid_gland1.07941937
93MP0005253_abnormal_eye_physiology1.07543833
94MP0002269_muscular_atrophy1.07063128
95MP0005386_behavior/neurological_phenoty1.06560567
96MP0004924_abnormal_behavior1.06560567
97MP0002066_abnormal_motor_capabilities/c1.05902061
98MP0009053_abnormal_anal_canal1.05701217
99MP0003635_abnormal_synaptic_transmissio1.05596994
100MP0003633_abnormal_nervous_system1.05308373
101MP0001501_abnormal_sleep_pattern1.05286179
102MP0002184_abnormal_innervation1.04693519
103MP0004197_abnormal_fetal_growth/weight/1.04303014
104MP0002092_abnormal_eye_morphology1.03745811
105MP0002111_abnormal_tail_morphology1.03246420
106MP0002751_abnormal_autonomic_nervous1.02574256
107MP0002572_abnormal_emotion/affect_behav1.01964775
108MP0000462_abnormal_digestive_system0.99871984
109MP0002733_abnormal_thermal_nociception0.99329526
110MP0003121_genomic_imprinting0.99035833
111MP0001905_abnormal_dopamine_level0.99006693
112MP0002233_abnormal_nose_morphology0.98904907
113MP0000749_muscle_degeneration0.98568638
114MP0000537_abnormal_urethra_morphology0.98475489
115MP0000566_synostosis0.97519649
116MP0002108_abnormal_muscle_morphology0.95621547
117MP0000467_abnormal_esophagus_morphology0.94054880
118MP0004885_abnormal_endolymph0.93603603
119MP0001299_abnormal_eye_distance/0.93123630
120MP0010352_gastrointestinal_tract_polyps0.92807125
121MP0005257_abnormal_intraocular_pressure0.92674350
122MP0003632_abnormal_nervous_system0.92305204
123MP0004270_analgesia0.92047726
124MP0008789_abnormal_olfactory_epithelium0.91451653
125MP0005075_abnormal_melanosome_morpholog0.90532736
126MP0002086_abnormal_extraembryonic_tissu0.90516921
127* MP0002152_abnormal_brain_morphology0.90148913
128MP0009780_abnormal_chondrocyte_physiolo0.89645549
129MP0002081_perinatal_lethality0.89603963
130MP0002009_preneoplasia0.89296791
131MP0009379_abnormal_foot_pigmentation0.88857420
132MP0004742_abnormal_vestibular_system0.88797826
133MP0009250_abnormal_appendicular_skeleto0.88651004
134MP0003631_nervous_system_phenotype0.88415567
135MP0004811_abnormal_neuron_physiology0.88163064
136* MP0001672_abnormal_embryogenesis/_devel0.87735655
137* MP0005380_embryogenesis_phenotype0.87735655
138MP0002909_abnormal_adrenal_gland0.87598682
139MP0000631_abnormal_neuroendocrine_gland0.87254941
140MP0009046_muscle_twitch0.86822877
141MP0002882_abnormal_neuron_morphology0.86707909
142MP0000534_abnormal_ureter_morphology0.85915448
143MP0001340_abnormal_eyelid_morphology0.85631713
144MP0002796_impaired_skin_barrier0.85290767
145MP0003172_abnormal_lysosome_physiology0.84185543
146MP0005645_abnormal_hypothalamus_physiol0.83728286
147MP0005195_abnormal_posterior_eye0.81965626
148MP0003634_abnormal_glial_cell0.81654685
149MP0002938_white_spotting0.80898833
150MP0005391_vision/eye_phenotype0.79585302
151MP0003879_abnormal_hair_cell0.79555311
152MP0000759_abnormal_skeletal_muscle0.78643690
153MP0003984_embryonic_growth_retardation0.78276544
154MP0002088_abnormal_embryonic_growth/wei0.78202172
155MP0002234_abnormal_pharynx_morphology0.78196065
156MP0001697_abnormal_embryo_size0.77619541
157MP0001346_abnormal_lacrimal_gland0.77569499
158MP0000747_muscle_weakness0.76555730
159MP0002229_neurodegeneration0.76053822

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.08220553
2Concave nail (HP:0001598)4.05937062
3Bilateral microphthalmos (HP:0007633)3.78819646
4Focal motor seizures (HP:0011153)3.68015349
5Coronal craniosynostosis (HP:0004440)3.61010475
6Abnormality of the lower motor neuron (HP:0002366)3.60249771
7Rectal fistula (HP:0100590)3.49241588
8Rectovaginal fistula (HP:0000143)3.49241588
9Turricephaly (HP:0000262)3.40592895
10Septo-optic dysplasia (HP:0100842)3.37517461
11Hypochromic microcytic anemia (HP:0004840)3.36320442
12Focal seizures (HP:0007359)3.14545413
13Annular pancreas (HP:0001734)3.14083209
14Intestinal fistula (HP:0100819)3.12473027
15Abnormality of the astrocytes (HP:0100707)3.03971843
16Astrocytoma (HP:0009592)3.03971843
17Abnormality of the diencephalon (HP:0010662)3.01941585
18Vaginal fistula (HP:0004320)2.99624641
19Hepatoblastoma (HP:0002884)2.99598568
20Progressive cerebellar ataxia (HP:0002073)2.97735307
21Short humerus (HP:0005792)2.86974146
22Split foot (HP:0001839)2.85804413
23Polyphagia (HP:0002591)2.80947171
24Renal duplication (HP:0000075)2.79799266
25Ulnar bowing (HP:0003031)2.74957031
26Aplasia/hypoplasia of the humerus (HP:0006507)2.71871369
27Facial hemangioma (HP:0000329)2.66370995
28Muscle fiber inclusion bodies (HP:0100299)2.65793818
29Ependymoma (HP:0002888)2.61067647
30Alacrima (HP:0000522)2.59578676
31Oligodactyly (hands) (HP:0001180)2.56586726
32Genetic anticipation (HP:0003743)2.52987731
33Limb dystonia (HP:0002451)2.52415871
34Muscle hypertrophy of the lower extremities (HP:0008968)2.52273220
35Febrile seizures (HP:0002373)2.48858701
36Broad alveolar ridges (HP:0000187)2.48093906
37Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.47437314
38Nemaline bodies (HP:0003798)2.42569402
39Abnormality of the aortic arch (HP:0012303)2.41819309
40Neoplasm of the heart (HP:0100544)2.40592247
41Optic nerve hypoplasia (HP:0000609)2.39481436
42Hemiplegia (HP:0002301)2.39057834
43Preaxial foot polydactyly (HP:0001841)2.37152429
44Abnormal eating behavior (HP:0100738)2.34411210
45Calf muscle hypertrophy (HP:0008981)2.32799537
46Short 5th finger (HP:0009237)2.31270491
47Vertebral fusion (HP:0002948)2.30470745
48Myotonia (HP:0002486)2.29746951
49Generalized tonic-clonic seizures (HP:0002069)2.27128117
50Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.27080157
51Hamartoma (HP:0010566)2.25393809
52Action tremor (HP:0002345)2.24522186
53Anteriorly placed anus (HP:0001545)2.22943846
54Abnormality of binocular vision (HP:0011514)2.21696949
55Diplopia (HP:0000651)2.21696949
56Exercise-induced muscle cramps (HP:0003710)2.21541333
57Abnormality of the labia minora (HP:0012880)2.21472343
58Tongue fasciculations (HP:0001308)2.21004824
59Difficulty running (HP:0009046)2.18967943
60Abnormality of the pubic bones (HP:0003172)2.18750537
61Glioma (HP:0009733)2.17381787
62Muscle fibrillation (HP:0010546)2.15549620
63Amyotrophic lateral sclerosis (HP:0007354)2.15323913
64Gastrointestinal atresia (HP:0002589)2.12859172
65Hypotrichosis (HP:0001006)2.10959456
66Narrow nasal bridge (HP:0000446)2.10917935
67Type II lissencephaly (HP:0007260)2.09738460
68Failure to thrive in infancy (HP:0001531)2.08793939
69Gait imbalance (HP:0002141)2.07288719
70Esophageal atresia (HP:0002032)2.06875010
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06520119
72Neoplasm of striated muscle (HP:0009728)2.06077520
73Partial duplication of thumb phalanx (HP:0009944)2.05651255
74Increased IgM level (HP:0003496)2.05343335
75Sleep apnea (HP:0010535)2.05191716
76Atonic seizures (HP:0010819)2.04925342
77Absent septum pellucidum (HP:0001331)2.04850886
78Hyperventilation (HP:0002883)2.03037504
79Type 1 muscle fiber predominance (HP:0003803)2.02651242
80Partial duplication of the phalanx of hand (HP:0009999)2.02542738
81True hermaphroditism (HP:0010459)2.01992895
82Broad toe (HP:0001837)2.01948910
83Bronchomalacia (HP:0002780)2.00915546
84Oligodactyly (HP:0012165)2.00848280
85Tented upper lip vermilion (HP:0010804)2.00637454
86Broad-based gait (HP:0002136)2.00388054
87Bifid tongue (HP:0010297)1.99745255
88Maternal diabetes (HP:0009800)1.98376991
89Choanal stenosis (HP:0000452)1.97907443
90Urinary bladder sphincter dysfunction (HP:0002839)1.97776885
91Nephronophthisis (HP:0000090)1.97726253
92Abnormality of the ischium (HP:0003174)1.96902220
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.96032854
94Broad thumb (HP:0011304)1.95133833
95Neurofibrillary tangles (HP:0002185)1.94941574
96Heterotopia (HP:0002282)1.93678621
97Short 4th metacarpal (HP:0010044)1.93040450
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93040450
99Drooling (HP:0002307)1.92676842
100Fetal akinesia sequence (HP:0001989)1.92187829
101Cutaneous finger syndactyly (HP:0010554)1.91803195
102Alopecia of scalp (HP:0002293)1.91162924
103Dialeptic seizures (HP:0011146)1.90581388
104Absence seizures (HP:0002121)1.90437830
105Ectopic anus (HP:0004397)1.90270600
106Congenital hip dislocation (HP:0001374)1.88518220
107Cerebral aneurysm (HP:0004944)1.87569362
108Shawl scrotum (HP:0000049)1.87446883
109Increased number of teeth (HP:0011069)1.86150606
110Distal arthrogryposis (HP:0005684)1.85848973
111Neoplasm of the oral cavity (HP:0100649)1.85731712
112Vertebral hypoplasia (HP:0008417)1.83209358
113Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.83209358
114Abnormality of midbrain morphology (HP:0002418)1.83185475
115Molar tooth sign on MRI (HP:0002419)1.83185475
116Hemiparesis (HP:0001269)1.82354868
117Abnormality of the salivary glands (HP:0010286)1.82318603
118Hypotelorism (HP:0000601)1.82157899
119Pancreatic fibrosis (HP:0100732)1.81557313
120Split hand (HP:0001171)1.80813850
121Small hand (HP:0200055)1.80635803
122Pachygyria (HP:0001302)1.79963902
123Anophthalmia (HP:0000528)1.79721116
124Decreased lacrimation (HP:0000633)1.79213789
125Large earlobe (HP:0009748)1.78199988
126Specific learning disability (HP:0001328)1.78133912
127Morphological abnormality of the inner ear (HP:0011390)1.78017982
128Generalized hypotonia (HP:0001290)1.77949575
129Hemivertebrae (HP:0002937)1.77803505
130Obstructive sleep apnea (HP:0002870)1.77749838
131Cutaneous syndactyly (HP:0012725)1.76210131
132Calcaneovalgus deformity (HP:0001848)1.75912602
133Mildly elevated creatine phosphokinase (HP:0008180)1.75894760
134Lissencephaly (HP:0001339)1.75817293
135Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75484395
136Fused cervical vertebrae (HP:0002949)1.75371837
137Clumsiness (HP:0002312)1.75155791
138Abnormality of the 4th metacarpal (HP:0010012)1.75153060
139Retinal dysplasia (HP:0007973)1.75104311
140Generalized amyotrophy (HP:0003700)1.72715440
141Orthostatic hypotension (HP:0001278)1.71673100
142Increased connective tissue (HP:0009025)1.71270553
143Overriding aorta (HP:0002623)1.71065851
144Congenital stationary night blindness (HP:0007642)1.70593415
145Muscle fiber splitting (HP:0003555)1.70284813
146Cerebellar dysplasia (HP:0007033)1.70179617
147Large for gestational age (HP:0001520)1.69827803
148Shallow orbits (HP:0000586)1.68605605
149Open mouth (HP:0000194)1.68017810
150Excessive salivation (HP:0003781)1.67578811
151Spastic tetraparesis (HP:0001285)1.65770997
152Sclerocornea (HP:0000647)1.65585383
153Abnormality of chromosome segregation (HP:0002916)1.64984946
154Myokymia (HP:0002411)1.64858388
155Exercise-induced myalgia (HP:0003738)1.64855065
156Fibular hypoplasia (HP:0003038)1.64838963
157Epileptic encephalopathy (HP:0200134)1.64452284
158Elfin facies (HP:0004428)1.64276867
159Hypoplastic ischia (HP:0003175)1.63997104
160Anomalous pulmonary venous return (HP:0010772)1.63930684
161Ankle clonus (HP:0011448)1.63472510
162Selective tooth agenesis (HP:0001592)1.62972258
163Volvulus (HP:0002580)1.62760999
164Synostosis involving bones of the lower limbs (HP:0009138)1.62609247
165Synostosis involving bones of the feet (HP:0009140)1.62609247
166Renovascular hypertension (HP:0100817)1.62591930
167Tracheomalacia (HP:0002779)1.62520991
168Pseudobulbar signs (HP:0002200)1.62445230
169Subaortic stenosis (HP:0001682)1.62122716
170Abnormality of the left ventricular outflow tract (HP:0011103)1.62122716
171Absent forearm bone (HP:0003953)1.62033960
172Aplasia involving forearm bones (HP:0009822)1.62033960
173Absent radius (HP:0003974)1.61730078
174Intestinal atresia (HP:0011100)1.61633455
175Renal dysplasia (HP:0000110)1.60948924
176Aplasia involving bones of the extremities (HP:0009825)1.56265649
177Aplasia involving bones of the upper limbs (HP:0009823)1.56265649
178Aplasia of the phalanges of the hand (HP:0009802)1.56265649
179Ankyloglossia (HP:0010296)1.55754994
180Megalencephaly (HP:0001355)1.55242840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.60109604
2TYRO33.99755060
3DDR23.98097106
4CASK3.83449481
5CDK123.62761295
6MAPK152.68125901
7MAP3K62.50944782
8MATK2.44457389
9MARK12.37640666
10UHMK12.33379089
11LATS22.32968853
12OBSCN2.31840049
13TNIK2.21742013
14PHKG12.20892243
15PHKG22.20892243
16PDGFRA2.19375102
17PNCK2.12814460
18GRK52.04669141
19BMX1.82738123
20NTRK21.70763292
21MAPK131.67951455
22PINK11.67581742
23MAP3K91.62847734
24FGR1.60718292
25PKN11.60311504
26FRK1.57518899
27MAP3K111.56203908
28EPHB21.54909652
29PRKD21.51943326
30ERN11.49922827
31EPHA31.47436822
32TRIB31.45460612
33DYRK1B1.43094026
34MAP3K41.41914070
35DAPK11.40252474
36MAP3K101.34763934
37PAK61.33929768
38SGK2231.33000788
39SGK4941.33000788
40MARK21.25473881
41GRK61.20881201
42SGK21.18797570
43DYRK21.18180748
44CDK71.14679682
45CDC42BPA1.13383359
46PRKCG1.11719977
47CSK1.11160933
48BMPR1B1.10593076
49RIPK11.09378023
50CSNK1G21.00999053
51NTRK10.99494709
52MAP2K70.99492871
53DYRK1A0.99427399
54KSR10.98025491
55WNK30.94486429
56CAMK2B0.94330550
57MTOR0.91638693
58MKNK20.88404177
59CAMK2A0.86862721
60DAPK20.86394036
61SIK10.84053312
62HIPK20.82800773
63CAMK2G0.82112038
64YES10.81647992
65PLK20.80845917
66CAMK1G0.80665151
67PRKD30.80503106
68CDK190.80242443
69CHEK20.80147003
70NEK60.77592238
71ERBB20.75989938
72CAMK10.74644364
73PRKAA10.74544353
74CAMK2D0.73501535
75CAMK40.71066085
76GSK3A0.70879834
77MINK10.70226491
78SIK20.69537259
79CDK180.69451031
80CDK150.69247280
81PRPF4B0.68518530
82DMPK0.67676693
83ROCK10.67111039
84ROCK20.66390432
85NME10.65838399
86STK38L0.65692359
87CAMKK10.65261479
88STK110.65121999
89PAK30.64565063
90SGK10.63793248
91TAOK10.63606024
92STK380.63540021
93AKT20.63005301
94CDK11A0.62449300
95MAPK70.62247288
96LMTK20.61620711
97ALK0.60929647
98CAMK1D0.60829683
99MAPKAPK50.60332975
100ERBB30.60100637
101ADRBK20.59826964
102SGK30.59299763
103MAP2K40.59235301
104EPHA40.58410562
105WNK10.57666789
106INSRR0.57055853
107WNK40.55845649
108MAPK120.55828349
109CDK140.55188217
110NEK10.53898845
111CSNK1G10.53503273
112GRK10.52805883
113CDK50.51262382
114PRKCH0.51076315
115CSNK1G30.50871946
116LATS10.50571895
117MAPK100.50531059
118PTK20.49797097
119CDK60.49794354
120PRKG10.49658173
121RPS6KA10.49641101
122CDK30.49628035
123RPS6KC10.49139069
124RPS6KL10.49139069
125FGFR10.48912873
126PAK40.48705658
127TNK20.48435678
128CSNK1D0.46955291
129PLK10.46576429
130CSF1R0.45777398
131MOS0.45497923
132AKT30.45035396
133ADRBK10.44658144
134BCR0.44375755
135FGFR20.44218661
136NTRK30.44164526
137TAOK20.44161751
138PDGFRB0.43053310
139CSNK1A1L0.42651534
140PRKCE0.42287082
141LIMK10.41556732
142PRKCZ0.41201241
143TTK0.40999724
144DYRK30.40252518
145MKNK10.39689730
146FGFR30.39634761
147PRKACA0.39483747
148TTN0.38495348
149CDK20.37797435
150MAPK110.37588633
151SIK30.37019247
152PAK20.35924725
153STK390.35062131
154MAP3K70.34080017
155RPS6KA30.33961281
156PIK3CA0.33725078
157RPS6KA60.33299922
158TGFBR20.33210462

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.61308562
2Basal cell carcinoma_Homo sapiens_hsa052172.92589025
3Hedgehog signaling pathway_Homo sapiens_hsa043402.90102790
4Notch signaling pathway_Homo sapiens_hsa043302.53640193
5Hippo signaling pathway_Homo sapiens_hsa043902.45633115
6Insulin secretion_Homo sapiens_hsa049112.24090223
7mTOR signaling pathway_Homo sapiens_hsa041502.23957144
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12324273
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84564477
10Phototransduction_Homo sapiens_hsa047441.84401504
11Wnt signaling pathway_Homo sapiens_hsa043101.84303991
12Cocaine addiction_Homo sapiens_hsa050301.80808251
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.76735338
14Axon guidance_Homo sapiens_hsa043601.76015803
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73896530
16Cholinergic synapse_Homo sapiens_hsa047251.69748373
17Adherens junction_Homo sapiens_hsa045201.58185460
18Dorso-ventral axis formation_Homo sapiens_hsa043201.50314583
19Gap junction_Homo sapiens_hsa045401.49430446
20mRNA surveillance pathway_Homo sapiens_hsa030151.49024961
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46190554
22Taste transduction_Homo sapiens_hsa047421.43961833
23Base excision repair_Homo sapiens_hsa034101.37199343
24Longevity regulating pathway - mammal_Homo sapiens_hsa042111.37183567
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36527556
26Bladder cancer_Homo sapiens_hsa052191.36066200
27Colorectal cancer_Homo sapiens_hsa052101.35769444
28VEGF signaling pathway_Homo sapiens_hsa043701.34367542
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32810464
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30457566
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28027895
32GABAergic synapse_Homo sapiens_hsa047271.27834596
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26231673
34ErbB signaling pathway_Homo sapiens_hsa040121.26130333
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25290083
36Butanoate metabolism_Homo sapiens_hsa006501.24117851
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22496772
38Fructose and mannose metabolism_Homo sapiens_hsa000511.22092241
39Melanogenesis_Homo sapiens_hsa049161.22004979
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20627803
41Choline metabolism in cancer_Homo sapiens_hsa052311.19965914
42Circadian rhythm_Homo sapiens_hsa047101.16787528
43Tight junction_Homo sapiens_hsa045301.16463240
44Endometrial cancer_Homo sapiens_hsa052131.16107060
45MicroRNAs in cancer_Homo sapiens_hsa052061.14668790
46Serotonergic synapse_Homo sapiens_hsa047261.14100176
47Proteoglycans in cancer_Homo sapiens_hsa052051.12506291
48Vitamin B6 metabolism_Homo sapiens_hsa007501.11802700
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10102406
50Oocyte meiosis_Homo sapiens_hsa041141.07705922
51GnRH signaling pathway_Homo sapiens_hsa049121.07406067
52Glutamatergic synapse_Homo sapiens_hsa047241.07129376
53TGF-beta signaling pathway_Homo sapiens_hsa043501.06278477
54AMPK signaling pathway_Homo sapiens_hsa041521.06051960
55Bile secretion_Homo sapiens_hsa049761.03341151
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02202366
57Nicotine addiction_Homo sapiens_hsa050331.02125740
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99836886
59Dilated cardiomyopathy_Homo sapiens_hsa054140.99140434
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97891855
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.94858950
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.92976879
63Long-term depression_Homo sapiens_hsa047300.92752607
64Viral myocarditis_Homo sapiens_hsa054160.92410989
65Rap1 signaling pathway_Homo sapiens_hsa040150.91269675
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90781272
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87361330
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86257037
69beta-Alanine metabolism_Homo sapiens_hsa004100.85488334
70Pathways in cancer_Homo sapiens_hsa052000.85290127
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84695091
72Glioma_Homo sapiens_hsa052140.84288859
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83825589
74Focal adhesion_Homo sapiens_hsa045100.83370665
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.82833129
76Oxytocin signaling pathway_Homo sapiens_hsa049210.81772725
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80705355
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.80445694
79Dopaminergic synapse_Homo sapiens_hsa047280.79923202
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79650867
81Estrogen signaling pathway_Homo sapiens_hsa049150.79000683
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77459159
83Lysine degradation_Homo sapiens_hsa003100.76863864
84Arginine and proline metabolism_Homo sapiens_hsa003300.76585493
85Insulin signaling pathway_Homo sapiens_hsa049100.76385559
86Circadian entrainment_Homo sapiens_hsa047130.76310515
87MAPK signaling pathway_Homo sapiens_hsa040100.75812897
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75713252
89Ovarian steroidogenesis_Homo sapiens_hsa049130.75111062
90Fatty acid metabolism_Homo sapiens_hsa012120.73144107
91Cardiac muscle contraction_Homo sapiens_hsa042600.73057204
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72969103
93Mismatch repair_Homo sapiens_hsa034300.72940917
94Long-term potentiation_Homo sapiens_hsa047200.72596034
95Salivary secretion_Homo sapiens_hsa049700.70349335
96Thyroid hormone synthesis_Homo sapiens_hsa049180.70071344
97Pancreatic secretion_Homo sapiens_hsa049720.69637293
98Histidine metabolism_Homo sapiens_hsa003400.69506659
99Propanoate metabolism_Homo sapiens_hsa006400.69286657
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69140735
101Galactose metabolism_Homo sapiens_hsa000520.68941373
102Chronic myeloid leukemia_Homo sapiens_hsa052200.68159633
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68087222
104Olfactory transduction_Homo sapiens_hsa047400.68018929
105cAMP signaling pathway_Homo sapiens_hsa040240.65917439
106Nitrogen metabolism_Homo sapiens_hsa009100.64414885
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.64362862
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63755431
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63184533
110Gastric acid secretion_Homo sapiens_hsa049710.62049117
111Ras signaling pathway_Homo sapiens_hsa040140.61600084
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61483050
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61239093
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61174092
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.60465962
116Non-small cell lung cancer_Homo sapiens_hsa052230.59427293
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59325303
118Endocytosis_Homo sapiens_hsa041440.59310470
119Renal cell carcinoma_Homo sapiens_hsa052110.59000733
120Synaptic vesicle cycle_Homo sapiens_hsa047210.58743305
121Renin secretion_Homo sapiens_hsa049240.57817936
122Thyroid cancer_Homo sapiens_hsa052160.57120437
123Ether lipid metabolism_Homo sapiens_hsa005650.56993953
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55661378
125Glucagon signaling pathway_Homo sapiens_hsa049220.54945868
126Pancreatic cancer_Homo sapiens_hsa052120.53957455
127Alzheimers disease_Homo sapiens_hsa050100.53475838
128Amphetamine addiction_Homo sapiens_hsa050310.52654410
129Calcium signaling pathway_Homo sapiens_hsa040200.51770068
130Linoleic acid metabolism_Homo sapiens_hsa005910.51691736
131Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51688127
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51335208
133Morphine addiction_Homo sapiens_hsa050320.48877842
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.47860748
135Parkinsons disease_Homo sapiens_hsa050120.42833742
136Type II diabetes mellitus_Homo sapiens_hsa049300.42674936
137Tryptophan metabolism_Homo sapiens_hsa003800.41054909
138PPAR signaling pathway_Homo sapiens_hsa033200.39866247
139Alcoholism_Homo sapiens_hsa050340.39520588
140Sulfur relay system_Homo sapiens_hsa041220.39011396

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