RFXANK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.10953640
2translational termination (GO:0006415)6.67219332
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.95433873
4translational elongation (GO:0006414)5.91504894
5cotranslational protein targeting to membrane (GO:0006613)5.83740002
6protein targeting to ER (GO:0045047)5.81818221
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.61148883
8establishment of protein localization to endoplasmic reticulum (GO:0072599)5.56936636
9protein localization to endoplasmic reticulum (GO:0070972)5.48860632
10viral life cycle (GO:0019058)5.41259652
11chaperone-mediated protein transport (GO:0072321)5.20911592
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.18664674
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.15679250
14ATP synthesis coupled proton transport (GO:0015986)5.15679250
15cellular protein complex disassembly (GO:0043624)5.08887081
16translational initiation (GO:0006413)4.90466487
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.64624246
18protein complex disassembly (GO:0043241)4.48796395
19pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.28852191
20translation (GO:0006412)4.24404503
21macromolecular complex disassembly (GO:0032984)4.21496324
22protein targeting to membrane (GO:0006612)4.02306655
23DNA deamination (GO:0045006)4.00362186
24respiratory electron transport chain (GO:0022904)3.98595473
25protein complex biogenesis (GO:0070271)3.95796706
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95305507
27electron transport chain (GO:0022900)3.90805980
28mitochondrial respiratory chain complex assembly (GO:0033108)3.89727106
29rRNA catabolic process (GO:0016075)3.80518256
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70616306
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.70616306
32NADH dehydrogenase complex assembly (GO:0010257)3.70616306
33ribosomal small subunit assembly (GO:0000028)3.69644424
34formation of translation preinitiation complex (GO:0001731)3.66710498
35protein targeting to mitochondrion (GO:0006626)3.65969988
36nuclear-transcribed mRNA catabolic process (GO:0000956)3.64946838
37cellular component biogenesis (GO:0044085)3.58509280
38telomere maintenance via semi-conservative replication (GO:0032201)3.58110592
39oxidative phosphorylation (GO:0006119)3.57848972
40pseudouridine synthesis (GO:0001522)3.50552925
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48938565
42negative regulation of ligase activity (GO:0051352)3.48938565
43mRNA catabolic process (GO:0006402)3.47736474
44pyrimidine nucleotide catabolic process (GO:0006244)3.43533868
45regulation of RIG-I signaling pathway (GO:0039535)3.42278332
46establishment of protein localization to mitochondrion (GO:0072655)3.41985512
47regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.41316812
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.38138885
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37321800
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37009449
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35724586
52guanosine-containing compound biosynthetic process (GO:1901070)3.34455593
53proteasome assembly (GO:0043248)3.34344462
54ribosomal large subunit biogenesis (GO:0042273)3.30396430
55rRNA modification (GO:0000154)3.29034619
56negative regulation of B cell apoptotic process (GO:0002903)3.27639823
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26696850
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26696850
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26254360
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26254360
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26254360
62protein localization to mitochondrion (GO:0070585)3.25369691
63RNA catabolic process (GO:0006401)3.23918723
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.21248616
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21248616
66DNA strand elongation involved in DNA replication (GO:0006271)3.21132111
67spliceosomal snRNP assembly (GO:0000387)3.19534920
68telomere maintenance via recombination (GO:0000722)3.18303635
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18265917
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.17948278
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.12968574
72DNA strand elongation (GO:0022616)3.12964863
73regulation of cellular amino acid metabolic process (GO:0006521)3.12313395
74rRNA processing (GO:0006364)3.12112762
75GTP biosynthetic process (GO:0006183)3.09418605
76purine nucleotide salvage (GO:0032261)3.09408649
77base-excision repair, AP site formation (GO:0006285)3.09277544
78CENP-A containing nucleosome assembly (GO:0034080)3.07083078
79purine nucleoside triphosphate biosynthetic process (GO:0009145)3.06933713
80protein neddylation (GO:0045116)3.06391969
81purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04677605
82ATP biosynthetic process (GO:0006754)3.03180448
83UTP biosynthetic process (GO:0006228)3.02964433
84regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.01514709
85nucleotide salvage (GO:0043173)2.99165432
86deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.99012585
87inner mitochondrial membrane organization (GO:0007007)2.98643492
88histone-serine phosphorylation (GO:0035404)2.98535616
89antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.97860134
90rRNA methylation (GO:0031167)2.97766964
91positive regulation of protein homodimerization activity (GO:0090073)2.97223102
92mitotic recombination (GO:0006312)2.97065456
93kinetochore assembly (GO:0051382)2.96489678
94rRNA metabolic process (GO:0016072)2.94915333
95establishment of viral latency (GO:0019043)2.94870272
96ribonucleoside triphosphate biosynthetic process (GO:0009201)2.94615298
97telomere maintenance via telomere lengthening (GO:0010833)2.93641980
98tRNA methylation (GO:0030488)2.93286159
99positive regulation of gamma-delta T cell activation (GO:0046645)2.92291064
100cytochrome complex assembly (GO:0017004)2.91788277
101chromatin remodeling at centromere (GO:0031055)2.91711456
102pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.91572075
103establishment of protein localization to membrane (GO:0090150)2.90361318
104pentose metabolic process (GO:0019321)2.88458532
105nucleoside salvage (GO:0043174)2.87878633
106DNA replication checkpoint (GO:0000076)2.87040225
107cellular response to exogenous dsRNA (GO:0071360)2.81747402
108cyclooxygenase pathway (GO:0019371)2.80861728
109purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.79330186
110positive regulation of B cell differentiation (GO:0045579)2.77818429
111fatty acid homeostasis (GO:0055089)2.77495813
112response to UV-B (GO:0010224)2.74992677
113regulation of interleukin-12 biosynthetic process (GO:0045075)2.74501948
114pantothenate metabolic process (GO:0015939)2.74440545
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.70540182
116transcription elongation from RNA polymerase III promoter (GO:0006385)2.69813055
117termination of RNA polymerase III transcription (GO:0006386)2.69813055
118L-methionine salvage (GO:0071267)2.69379444
119L-methionine biosynthetic process (GO:0071265)2.69379444
120amino acid salvage (GO:0043102)2.69379444
121purine deoxyribonucleotide catabolic process (GO:0009155)2.68748628
122NIK/NF-kappaB signaling (GO:0038061)2.67314132
123termination of RNA polymerase I transcription (GO:0006363)2.67107544
124purine nucleobase biosynthetic process (GO:0009113)2.66400990
125iron-sulfur cluster assembly (GO:0016226)2.65017804
126metallo-sulfur cluster assembly (GO:0031163)2.65017804
127negative regulation of telomere maintenance (GO:0032205)2.63802497
128DNA replication initiation (GO:0006270)2.62019546
129transcription-coupled nucleotide-excision repair (GO:0006283)2.61084286
130DNA synthesis involved in DNA repair (GO:0000731)2.57008502
131positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56217298
132positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55084502
133DNA-dependent DNA replication (GO:0006261)2.54395876
134nucleobase biosynthetic process (GO:0046112)2.53943723
135regulation of gamma-delta T cell differentiation (GO:0045586)2.53339541
136ribonucleoprotein complex biogenesis (GO:0022613)2.52685089
137amino sugar catabolic process (GO:0046348)2.52665578
138intra-S DNA damage checkpoint (GO:0031573)2.52027382
139kinetochore organization (GO:0051383)2.51802648
140ncRNA catabolic process (GO:0034661)2.51785423
141deoxyribonucleotide catabolic process (GO:0009264)2.51711632
142transcription from RNA polymerase I promoter (GO:0006360)2.50597833
143RNA methylation (GO:0001510)2.50266421
144regulation of mitochondrial translation (GO:0070129)2.49925294
145poly(A)+ mRNA export from nucleus (GO:0016973)2.47601750
146histone H2A acetylation (GO:0043968)2.47384559
147regulation of gamma-delta T cell activation (GO:0046643)2.45765069
148methionine biosynthetic process (GO:0009086)2.43830865
149positive regulation of interleukin-8 secretion (GO:2000484)2.42879517
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41583906
151cellular response to interferon-beta (GO:0035458)2.41371692
152negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.41368183
153GDP-mannose metabolic process (GO:0019673)2.40553197
154transcription elongation from RNA polymerase I promoter (GO:0006362)2.40009280
155ribosome biogenesis (GO:0042254)2.39591141
156antigen processing and presentation of endogenous antigen (GO:0019883)2.38687467
157tolerance induction (GO:0002507)2.38325569
158ribosomal small subunit biogenesis (GO:0042274)2.38280090
159attachment of spindle microtubules to kinetochore (GO:0008608)2.37863030
160telomere maintenance (GO:0000723)2.36384688
1617-methylguanosine mRNA capping (GO:0006370)2.35349900
162telomere organization (GO:0032200)2.35267628
163response to interferon-beta (GO:0035456)2.34860311
164dendritic cell chemotaxis (GO:0002407)2.34233104
165cellular response to interleukin-15 (GO:0071350)2.34205061
166maturation of SSU-rRNA (GO:0030490)2.33096396
167DNA replication-independent nucleosome organization (GO:0034724)2.32418798
168DNA replication-independent nucleosome assembly (GO:0006336)2.32418798
169deoxyribose phosphate catabolic process (GO:0046386)2.32153605
170tRNA modification (GO:0006400)2.31717374
171regulation of B cell differentiation (GO:0045577)2.29940609
172daunorubicin metabolic process (GO:0044597)2.27450827
173polyketide metabolic process (GO:0030638)2.27450827
174doxorubicin metabolic process (GO:0044598)2.27450827
175transcription initiation from RNA polymerase I promoter (GO:0006361)2.25936224
176RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.25685406
177tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.25685406
178regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.24217935
179regulation of metalloenzyme activity (GO:0048552)2.23797764
1807-methylguanosine RNA capping (GO:0009452)2.23299998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.54784115
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.41316050
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91198645
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85881048
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85051775
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75216980
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.72037411
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.66840484
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.58075244
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.58070373
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50425736
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47295639
13* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.37913796
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37750620
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33258243
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30769691
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.25818404
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.24307474
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23073323
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13430268
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11216109
22* VDR_23849224_ChIP-Seq_CD4+_Human2.09946301
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.08095506
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04973618
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00523038
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93742075
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90444323
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.90242444
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.83732735
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82700214
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81295254
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80998916
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79757263
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76286216
35* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.76024234
36XRN2_22483619_ChIP-Seq_HELA_Human1.75384313
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72565596
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72204046
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71399303
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70868370
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.69691111
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69372927
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69289308
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65793143
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65469840
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62097596
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58222367
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56392556
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53840823
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52369963
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.51360848
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50550207
53CIITA_25753668_ChIP-Seq_RAJI_Human1.48330749
54* SPI1_23547873_ChIP-Seq_NB4_Human1.45657517
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.42740579
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42113910
57* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41519525
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40351523
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40297959
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37507966
61CTCF_18555785_ChIP-Seq_MESCs_Mouse1.37008958
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.36020831
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35393295
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34461612
65IRF1_19129219_ChIP-ChIP_H3396_Human1.33401627
66TTF2_22483619_ChIP-Seq_HELA_Human1.30425249
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27999369
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27000911
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26166885
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.26033808
71MYC_18940864_ChIP-ChIP_HL60_Human1.26021147
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.25672766
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24670676
74VDR_21846776_ChIP-Seq_THP-1_Human1.24513923
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24237572
76GABP_19822575_ChIP-Seq_HepG2_Human1.23288403
77CTCF_26484167_Chip-Seq_Bcells_Mouse1.23027181
78DCP1A_22483619_ChIP-Seq_HELA_Human1.21712793
79SCL_19346495_ChIP-Seq_HPC-7_Human1.21658461
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20736241
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18127041
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17831729
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17086787
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15862439
85ZNF263_19887448_ChIP-Seq_K562_Human1.15195993
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14658676
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14465944
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14115474
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13778892
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.13623669
91* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13047888
92LXR_22292898_ChIP-Seq_THP-1_Human1.12776946
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.12764675
94FOXP1_21924763_ChIP-Seq_HESCs_Human1.09785006
95MAF_26560356_Chip-Seq_TH2_Human1.09720594
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09719698
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09537542
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09470155
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07062381
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06936937
101E2F1_21310950_ChIP-Seq_MCF-7_Human1.05966822
102BCL6_27268052_Chip-Seq_Bcells_Human1.05508384
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04482156
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03033288
105ELK1_19687146_ChIP-ChIP_HELA_Human1.02809964
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02664086
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02292181
108MAF_26560356_Chip-Seq_TH1_Human1.02012704
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01955686
110P68_20966046_ChIP-Seq_HELA_Human1.00920344
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00598424
112MYC_22102868_ChIP-Seq_BL_Human1.00152102
113SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00125428
114AR_21909140_ChIP-Seq_LNCAP_Human1.00022927
115MYB_26560356_Chip-Seq_TH1_Human0.99452344
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98068664
117KDM5A_27292631_Chip-Seq_BREAST_Human0.97911095
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.97691755
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97543050
120VDR_24763502_ChIP-Seq_THP-1_Human0.97226318
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97210516
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94494090
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94040300
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.93029891
125KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92887888
126YY1_22570637_ChIP-Seq_MALME-3M_Human0.92771649
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92739394
128BP1_19119308_ChIP-ChIP_Hs578T_Human0.92653427
129BCOR_27268052_Chip-Seq_Bcells_Human0.91656998
130UTX_26944678_Chip-Seq_JUKART_Human0.91568188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.07837462
2MP0008058_abnormal_DNA_repair2.85456675
3MP0001835_abnormal_antigen_presentation2.74874891
4MP0010030_abnormal_orbit_morphology2.71761395
5MP0005671_abnormal_response_to2.68670008
6MP0003111_abnormal_nucleus_morphology2.64999931
7MP0003693_abnormal_embryo_hatching2.59011807
8MP0003806_abnormal_nucleotide_metabolis2.48361295
9MP0006036_abnormal_mitochondrial_physio2.45884330
10MP0003763_abnormal_thymus_physiology2.43203757
11MP0008007_abnormal_cellular_replicative2.37377513
12MP0005058_abnormal_lysosome_morphology2.29172813
13MP0010094_abnormal_chromosome_stability2.27867473
14MP0002132_abnormal_respiratory_system2.27148332
15MP0009785_altered_susceptibility_to2.22489317
16MP0001800_abnormal_humoral_immune2.18049007
17MP0005377_hearing/vestibular/ear_phenot2.17475971
18MP0003878_abnormal_ear_physiology2.17475971
19MP0003866_abnormal_defecation2.12591021
20MP0003718_maternal_effect2.11943828
21MP0009333_abnormal_splenocyte_physiolog2.08354350
22MP0009840_abnormal_foam_cell2.02307528
23MP0000490_abnormal_crypts_of1.99982178
24MP0006035_abnormal_mitochondrial_morpho1.94760634
25MP0001873_stomach_inflammation1.91884475
26MP0003077_abnormal_cell_cycle1.89075058
27MP0002452_abnormal_antigen_presenting1.83280736
28MP0010155_abnormal_intestine_physiology1.82109108
29MP0000685_abnormal_immune_system1.81704052
30MP0002398_abnormal_bone_marrow1.78865147
31MP0002420_abnormal_adaptive_immunity1.77254289
32MP0002723_abnormal_immune_serum1.77138083
33MP0000689_abnormal_spleen_morphology1.76189623
34MP0005025_abnormal_response_to1.76127012
35MP0002653_abnormal_ependyma_morphology1.75679788
36MP0001853_heart_inflammation1.75353461
37MP0001819_abnormal_immune_cell1.75105740
38MP0001790_abnormal_immune_system1.74238801
39MP0005387_immune_system_phenotype1.74238801
40MP0003186_abnormal_redox_activity1.73499782
41MP0000372_irregular_coat_pigmentation1.73145426
42MP0002148_abnormal_hypersensitivity_rea1.64909084
43MP0002419_abnormal_innate_immunity1.62943813
44MP0005174_abnormal_tail_pigmentation1.62455829
45MP0000716_abnormal_immune_system1.60572538
46MP0002722_abnormal_immune_system1.59600062
47MP0005000_abnormal_immune_tolerance1.57989521
48MP0003724_increased_susceptibility_to1.52476071
49MP0005075_abnormal_melanosome_morpholog1.47010426
50MP0005464_abnormal_platelet_physiology1.45651310
51MP0002429_abnormal_blood_cell1.45559429
52MP0009278_abnormal_bone_marrow1.40078842
53MP0008057_abnormal_DNA_replication1.36049302
54MP0004147_increased_porphyrin_level1.35341534
55MP0000678_abnormal_parathyroid_gland1.34739445
56MP0002405_respiratory_system_inflammati1.33992822
57MP0003315_abnormal_perineum_morphology1.33092357
58MP0003436_decreased_susceptibility_to1.32628173
59MP0000358_abnormal_cell_content/1.32261291
60MP0001764_abnormal_homeostasis1.31409193
61MP0000465_gastrointestinal_hemorrhage1.30376469
62MP0001986_abnormal_taste_sensitivity1.29293545
63MP0008469_abnormal_protein_level1.28767690
64MP0000703_abnormal_thymus_morphology1.28028295
65MP0002234_abnormal_pharynx_morphology1.27586115
66MP0009379_abnormal_foot_pigmentation1.25562180
67MP0002938_white_spotting1.24683511
68MP0001845_abnormal_inflammatory_respons1.24152634
69MP0004808_abnormal_hematopoietic_stem1.20308196
70MP0002095_abnormal_skin_pigmentation1.20081076
71MP0004381_abnormal_hair_follicle1.19196633
72MP0005084_abnormal_gallbladder_morpholo1.18829259
73MP0003567_abnormal_fetal_cardiomyocyte1.18512774
74MP0008789_abnormal_olfactory_epithelium1.17238714
75MP0002163_abnormal_gland_morphology1.17069467
76MP0000343_altered_response_to1.16585188
77MP0003656_abnormal_erythrocyte_physiolo1.13201875
78MP0004957_abnormal_blastocyst_morpholog1.12941971
79MP0000049_abnormal_middle_ear1.12918586
80MP0002019_abnormal_tumor_incidence1.11832760
81MP0006292_abnormal_olfactory_placode1.10397736
82MP0001293_anophthalmia1.07650056
83MP0000015_abnormal_ear_pigmentation1.07319605
84MP0005451_abnormal_body_composition1.05832011
85MP0005083_abnormal_biliary_tract1.02061269
86MP0003786_premature_aging1.00523186
87MP0004264_abnormal_extraembryonic_tissu0.98577300
88MP0001188_hyperpigmentation0.98300471
89MP0002876_abnormal_thyroid_physiology0.97503145
90MP0003191_abnormal_cellular_cholesterol0.96763013
91MP0000350_abnormal_cell_proliferation0.96282870
92MP0000566_synostosis0.93786628
93MP0005670_abnormal_white_adipose0.92249689
94MP0009763_increased_sensitivity_to0.91970008
95MP0001119_abnormal_female_reproductive0.91882855
96MP0001881_abnormal_mammary_gland0.87613808
97MP0009643_abnormal_urine_homeostasis0.86416313
98MP0002166_altered_tumor_susceptibility0.85869941
99MP0000477_abnormal_intestine_morphology0.84599236
100MP0005085_abnormal_gallbladder_physiolo0.82497756
101MP0009697_abnormal_copulation0.82339388
102MP0003136_yellow_coat_color0.82263519
103MP0000858_altered_metastatic_potential0.81735979
104MP0002277_abnormal_respiratory_mucosa0.81109280
105MP0002160_abnormal_reproductive_system0.80849263
106MP0000313_abnormal_cell_death0.80499831
107MP0004019_abnormal_vitamin_homeostasis0.80172426
108MP0001545_abnormal_hematopoietic_system0.80163557
109MP0005397_hematopoietic_system_phenotyp0.80163557
110MP0008004_abnormal_stomach_pH0.79719587
111MP0000750_abnormal_muscle_regeneration0.79194917
112MP0003828_pulmonary_edema0.78448636
113MP0003252_abnormal_bile_duct0.78020719
114MP0008260_abnormal_autophagy0.77802022
115MP0005330_cardiomyopathy0.76886373
116MP0009765_abnormal_xenobiotic_induced0.76808533
117MP0005395_other_phenotype0.76615311
118MP0001663_abnormal_digestive_system0.76416214
119MP0005409_darkened_coat_color0.76125109
120MP0002249_abnormal_larynx_morphology0.76067073
121MP0009764_decreased_sensitivity_to0.75310274
122MP0008932_abnormal_embryonic_tissue0.75182716
123MP0005501_abnormal_skin_physiology0.73318573
124MP0001730_embryonic_growth_arrest0.73185839
125MP0005389_reproductive_system_phenotype0.71980402
126MP0001919_abnormal_reproductive_system0.71459003
127MP0002138_abnormal_hepatobiliary_system0.71395347
128MP0002080_prenatal_lethality0.71207028
129MP0003075_altered_response_to0.70883026
130MP0003303_peritoneal_inflammation0.69295204
131MP0005499_abnormal_olfactory_system0.67733493
132MP0005394_taste/olfaction_phenotype0.67733493
133MP0001529_abnormal_vocalization0.67656366
134MP0005319_abnormal_enzyme/_coenzyme0.67123868
135MP0008995_early_reproductive_senescence0.66894854
136MP0001905_abnormal_dopamine_level0.63214570
137MP0005408_hypopigmentation0.59385971

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.39547111
2Acute necrotizing encephalopathy (HP:0006965)5.33599802
3Mitochondrial inheritance (HP:0001427)4.88022558
4Acute encephalopathy (HP:0006846)4.86671285
5Increased CSF lactate (HP:0002490)4.16317595
6Progressive macrocephaly (HP:0004481)4.15484270
7Petechiae (HP:0000967)3.98636403
8Renal Fanconi syndrome (HP:0001994)3.97103101
9Increased intramyocellular lipid droplets (HP:0012240)3.91294355
10Increased hepatocellular lipid droplets (HP:0006565)3.87617637
11Lipid accumulation in hepatocytes (HP:0006561)3.76073251
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.75253942
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.75253942
14Pallor (HP:0000980)3.69494518
15Increased muscle lipid content (HP:0009058)3.67400844
16Chronic otitis media (HP:0000389)3.63363327
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61039682
18Cerebral edema (HP:0002181)3.50192597
19Type I transferrin isoform profile (HP:0003642)3.47972448
20Birth length less than 3rd percentile (HP:0003561)3.43885284
21* Panhypogammaglobulinemia (HP:0003139)3.38562128
22Thyroid-stimulating hormone excess (HP:0002925)3.33670027
23Chromsome breakage (HP:0040012)3.29961217
24Lactic acidosis (HP:0003128)3.25620865
25Prolonged neonatal jaundice (HP:0006579)3.03024050
26Respiratory difficulties (HP:0002880)3.01972965
27Exercise intolerance (HP:0003546)3.01615706
28IgM deficiency (HP:0002850)3.01105192
29Respiratory failure (HP:0002878)3.01060438
30* Agammaglobulinemia (HP:0004432)2.91662039
31Breast hypoplasia (HP:0003187)2.87530455
32Elevated erythrocyte sedimentation rate (HP:0003565)2.83628674
33Reduced antithrombin III activity (HP:0001976)2.69883041
34Reticulocytopenia (HP:0001896)2.66584234
35Thrombocytosis (HP:0001894)2.65377632
36Abnormal number of erythroid precursors (HP:0012131)2.62694587
37Granulocytopenia (HP:0001913)2.54098595
38Aplastic anemia (HP:0001915)2.54069321
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53053130
40Dicarboxylic aciduria (HP:0003215)2.53053130
41Abnormality of cells of the erythroid lineage (HP:0012130)2.45771232
42Myositis (HP:0100614)2.45400259
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43117314
443-Methylglutaconic aciduria (HP:0003535)2.41727253
45Hypertensive crisis (HP:0100735)2.39817691
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37178565
47Abnormality of the anterior horn cell (HP:0006802)2.36618817
48Degeneration of anterior horn cells (HP:0002398)2.36618817
49Stomach cancer (HP:0012126)2.35379930
50Macrocytic anemia (HP:0001972)2.29394367
51* Encephalitis (HP:0002383)2.27558134
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27324097
53Abnormal protein N-linked glycosylation (HP:0012347)2.27324097
54Abnormal protein glycosylation (HP:0012346)2.27324097
55Abnormal glycosylation (HP:0012345)2.27324097
56Leukodystrophy (HP:0002415)2.26803729
57Hyperglycinuria (HP:0003108)2.24952027
58Abnormality of reticulocytes (HP:0004312)2.24736650
59Hepatosplenomegaly (HP:0001433)2.24225113
60Abnormality of the preputium (HP:0100587)2.24172210
61Meckel diverticulum (HP:0002245)2.23642192
62Chronic obstructive pulmonary disease (HP:0006510)2.22873721
63Obstructive lung disease (HP:0006536)2.22873721
64Abnormality of B cell number (HP:0010975)2.22323281
65B lymphocytopenia (HP:0010976)2.22323281
66Lethargy (HP:0001254)2.21157371
67Bone marrow hypocellularity (HP:0005528)2.19910137
68Pancytopenia (HP:0001876)2.19855212
69Seborrheic dermatitis (HP:0001051)2.19659846
70Abnormality of eosinophils (HP:0001879)2.19426421
71Eosinophilia (HP:0001880)2.18869175
72* Meningitis (HP:0001287)2.18586979
73Clubbing of toes (HP:0100760)2.17795515
74Abnormality of renal resorption (HP:0011038)2.17584008
75Optic disc pallor (HP:0000543)2.15987847
76Recurrent abscess formation (HP:0002722)2.15805244
77Abnormality of the prostate (HP:0008775)2.15672207
78Abnormality of pyrimidine metabolism (HP:0004353)2.12539467
79Severe combined immunodeficiency (HP:0004430)2.11998997
80* Recurrent viral infections (HP:0004429)2.11343213
81Retrobulbar optic neuritis (HP:0100654)2.09922807
82Optic neuritis (HP:0100653)2.09922807
83Overlapping toe (HP:0001845)2.09678992
84Nonimmune hydrops fetalis (HP:0001790)2.09486709
85Ragged-red muscle fibers (HP:0003200)2.08392257
86Abnormality of fatty-acid metabolism (HP:0004359)2.07539952
87Colon cancer (HP:0003003)2.06666772
88Abnormality of the ileum (HP:0001549)2.06383949
89Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06219093
90Testicular atrophy (HP:0000029)2.05278008
91Exertional dyspnea (HP:0002875)2.04260547
92Microcytic anemia (HP:0001935)2.03449047
93Pustule (HP:0200039)2.01941834
94Microretrognathia (HP:0000308)1.98856479
95Increased serum pyruvate (HP:0003542)1.98479248
96Cholecystitis (HP:0001082)1.96136436
97Abnormal gallbladder physiology (HP:0012438)1.96136436
98Hepatic necrosis (HP:0002605)1.93679023
99IgG deficiency (HP:0004315)1.93637070
100Abnormal trabecular bone morphology (HP:0100671)1.93605380
101Mediastinal lymphadenopathy (HP:0100721)1.93375089
102Lymphoma (HP:0002665)1.92309931
103Prolonged partial thromboplastin time (HP:0003645)1.91796507
104Methylmalonic aciduria (HP:0012120)1.91058621
105Leukopenia (HP:0001882)1.90691607
106Muscle fiber atrophy (HP:0100295)1.90644255
107Oral leukoplakia (HP:0002745)1.89345322
108Recurrent bacterial skin infections (HP:0005406)1.89116216
109Optic nerve coloboma (HP:0000588)1.88216047
110Absent thumb (HP:0009777)1.88112487
111* Abnormality of T cell physiology (HP:0011840)1.88023256
112Megaloblastic anemia (HP:0001889)1.86639035
113Cerebral hypomyelination (HP:0006808)1.86606917
114Increased neuronal autofluorescent lipopigment (HP:0002074)1.86509380
115* Abnormal delayed hypersensitivity skin test (HP:0002963)1.86187618
116Emotional lability (HP:0000712)1.85601788
117Prolonged bleeding time (HP:0003010)1.84872367
118Duplicated collecting system (HP:0000081)1.84610890
119Eczematoid dermatitis (HP:0000976)1.84497834
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.84146348
121Self-mutilation (HP:0000742)1.83461066
122Aplasia/Hypoplasia of the thymus (HP:0010515)1.82486377
123Orchitis (HP:0100796)1.81839489
124CNS demyelination (HP:0007305)1.81666624
125Abnormality of the renal collecting system (HP:0004742)1.81604139
126Broad distal phalanx of finger (HP:0009836)1.81492979
127Combined immunodeficiency (HP:0005387)1.80873881
128Abnormality of glycolysis (HP:0004366)1.80873782
129Hepatocellular necrosis (HP:0001404)1.80828837
130Renal cortical cysts (HP:0000803)1.80707860
131Progressive muscle weakness (HP:0003323)1.78712996
132Microvesicular hepatic steatosis (HP:0001414)1.78425506
133Hypoplastic pelvis (HP:0008839)1.78376011
134Increased serum lactate (HP:0002151)1.77349866
135Rough bone trabeculation (HP:0100670)1.76548496
136Recurrent bronchitis (HP:0002837)1.76070366
137Truncus arteriosus (HP:0001660)1.75809197
138Skin rash (HP:0000988)1.74822686
139Abnormality of the heme biosynthetic pathway (HP:0010472)1.74001861
140* Abnormality of T cells (HP:0002843)1.73995416
141Horseshoe kidney (HP:0000085)1.73889912
142Epistaxis (HP:0000421)1.73600905
143Hyperglycinemia (HP:0002154)1.73305241
144Vacuolated lymphocytes (HP:0001922)1.72899327
145Myelodysplasia (HP:0002863)1.72536518
146Abnormal pupillary function (HP:0007686)1.72074296
147Cellulitis (HP:0100658)1.71294608
148Abnormality of secondary sexual hair (HP:0009888)1.71293006
149Abnormality of the axillary hair (HP:0100134)1.71293006
150Congenital, generalized hypertrichosis (HP:0004540)1.69389486
151Nausea (HP:0002018)1.69268948
152Small intestinal stenosis (HP:0012848)1.69203297
153Duodenal stenosis (HP:0100867)1.69203297
154Increased cerebral lipofuscin (HP:0011813)1.69030459
155Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68477138
156* Recurrent fungal infections (HP:0002841)1.68407494
157Multiple enchondromatosis (HP:0005701)1.67462926
158Hypoplastic left heart (HP:0004383)1.67441986
159Abnormality of macrophages (HP:0004311)1.66988858
160Cleft eyelid (HP:0000625)1.66433280
161Hypokinesia (HP:0002375)1.65655830
162Cerebral palsy (HP:0100021)1.64220009
163Death in infancy (HP:0001522)1.63330892
164* Neutropenia (HP:0001875)1.61207071
165Type 2 muscle fiber atrophy (HP:0003554)1.61115237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.03320613
2IRAK34.50092311
3STK163.69673166
4ZAK3.60069029
5TIE13.43833617
6BUB13.25734892
7SMG13.25031286
8TNIK2.98186408
9TEC2.55286553
10NLK2.51747005
11IRAK42.38760180
12WEE12.29061498
13ERN12.11052896
14KIT2.08448285
15TXK2.08061266
16ZAP702.04591544
17MAP4K12.00208365
18NME11.94078548
19MAP2K31.93801500
20MAP3K111.91868550
21BRSK21.80784047
22TAF11.79245038
23NME21.58759710
24BCKDK1.54062608
25ARAF1.50829402
26LRRK21.50661303
27TLK11.46321775
28PBK1.45393365
29BTK1.44661033
30FLT31.43417659
31IRAK21.42007103
32IKBKB1.41825949
33TSSK61.38673171
34CLK11.33885399
35SRPK11.30326764
36NEK11.30212658
37GRK11.28104499
38PIK3CA1.27732942
39EIF2AK31.27334091
40TESK11.22499995
41IKBKE1.20267061
42CDK81.19533570
43TTK1.18303126
44MAP3K141.18009431
45ABL21.15378653
46IRAK11.15237913
47MKNK11.14627311
48EIF2AK21.10854490
49NUAK11.09921470
50MAP3K61.07989212
51PLK41.07583653
52PDK21.05769237
53DAPK31.03230274
54PIM21.00412428
55TESK21.00051213
56KDR0.99808067
57DAPK10.98983615
58AURKA0.96970451
59CHUK0.95639714
60JAK30.93850268
61STK40.93567372
62SIK30.93452475
63DYRK20.92855052
64BLK0.91221199
65ILK0.90983658
66EEF2K0.89637501
67CDK190.88804951
68TYK20.87514501
69VRK10.87369033
70MAP2K60.84750851
71PAK40.84029362
72STK100.83672551
73MKNK20.83618078
74BRSK10.80856177
75LIMK10.80643948
76TBK10.79922526
77ITK0.78977245
78ADRBK20.78620921
79CDK30.73946192
80PLK10.72448530
81PIM10.72219001
82ATR0.71550078
83RPS6KA40.71152155
84MAP3K70.70745433
85SYK0.70381791
86YES10.68601192
87MAPK110.68535884
88MAP3K30.67217083
89CDC70.66702000
90MAPKAPK30.66665001
91LYN0.66497567
92EPHA20.65875316
93CSNK1G30.65573512
94MAPKAPK50.63889598
95MARK30.63058969
96CSF1R0.62671659
97RPS6KA50.62499923
98AURKB0.62248123
99CCNB10.61059853
100LCK0.60652412
101CDK70.58502105
102PRKAA20.58434240
103MAP2K20.57269335
104RIPK40.57000220
105RPS6KB20.56788309
106CSNK2A20.56722186
107PASK0.54266838
108EIF2AK10.52528551
109CDK90.51190712
110TNK20.50793654
111MYLK0.50749462
112NEK20.50441620
113FES0.49780923
114AKT30.49421242
115DYRK30.48201303
116EPHB20.47407466
117TRIB30.47232511
118PRKCI0.46045293
119SCYL20.45945302
120MAPK70.44916236
121PAK10.43708006
122RAF10.40083578
123BRAF0.39936291
124CDK40.39663477
125MAPKAPK20.39414805
126TAOK20.38014933
127MUSK0.37832172
128CSNK1A1L0.37808587
129PRKD30.37702673
130MAPK40.37156453
131TAOK10.36195567
132CHEK20.34780517
133PLK30.31707592
134SGK20.30861121
135CHEK10.30644047
136MAP3K80.29805860
137TGFBR10.29451044
138CSNK2A10.29108125
139GRK60.28968680
140TRPM70.27699876
141NEK60.27388539

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.45301633
2Mismatch repair_Homo sapiens_hsa034302.90733050
3RNA polymerase_Homo sapiens_hsa030202.80700616
4Homologous recombination_Homo sapiens_hsa034402.59726804
5Sulfur relay system_Homo sapiens_hsa041222.55761624
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.52552296
7Ribosome_Homo sapiens_hsa030102.51574258
8Base excision repair_Homo sapiens_hsa034102.44134633
9Proteasome_Homo sapiens_hsa030502.25791804
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25444240
11* Primary immunodeficiency_Homo sapiens_hsa053402.21418462
12Pyrimidine metabolism_Homo sapiens_hsa002402.17275384
13Alzheimers disease_Homo sapiens_hsa050102.13732687
14Fanconi anemia pathway_Homo sapiens_hsa034602.01818799
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.82522683
16One carbon pool by folate_Homo sapiens_hsa006701.75992239
17Spliceosome_Homo sapiens_hsa030401.69742729
18Nucleotide excision repair_Homo sapiens_hsa034201.65786488
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.61586936
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60934570
21Arachidonic acid metabolism_Homo sapiens_hsa005901.60852706
22Non-homologous end-joining_Homo sapiens_hsa034501.56579469
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.56269988
24Vitamin B6 metabolism_Homo sapiens_hsa007501.42602186
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38512357
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30412948
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30049152
28Purine metabolism_Homo sapiens_hsa002301.29091541
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.28678444
30Basal transcription factors_Homo sapiens_hsa030221.28599189
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27243198
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25803723
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25614393
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23716934
35Pentose phosphate pathway_Homo sapiens_hsa000301.20166975
36Cell cycle_Homo sapiens_hsa041101.17515460
37Vitamin digestion and absorption_Homo sapiens_hsa049771.15543150
38Regulation of autophagy_Homo sapiens_hsa041401.10751025
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.09184714
40Fatty acid elongation_Homo sapiens_hsa000621.08502477
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05559407
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.04856346
43Linoleic acid metabolism_Homo sapiens_hsa005911.04838852
44RNA transport_Homo sapiens_hsa030131.04541290
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03712357
46Glutathione metabolism_Homo sapiens_hsa004801.03698239
47Herpes simplex infection_Homo sapiens_hsa051681.03446089
48Selenocompound metabolism_Homo sapiens_hsa004501.03022487
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.02776805
50p53 signaling pathway_Homo sapiens_hsa041150.99989675
51Measles_Homo sapiens_hsa051620.99343799
52Leishmaniasis_Homo sapiens_hsa051400.97859651
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97700679
54Folate biosynthesis_Homo sapiens_hsa007900.97520082
55Peroxisome_Homo sapiens_hsa041460.96957259
56Hematopoietic cell lineage_Homo sapiens_hsa046400.96343620
57Other glycan degradation_Homo sapiens_hsa005110.94419829
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.94354080
59Cardiac muscle contraction_Homo sapiens_hsa042600.94117040
60Graft-versus-host disease_Homo sapiens_hsa053320.94055651
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91775998
62Epstein-Barr virus infection_Homo sapiens_hsa051690.89073747
63ABC transporters_Homo sapiens_hsa020100.88603334
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88320202
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85666297
66Asthma_Homo sapiens_hsa053100.85309802
67RNA degradation_Homo sapiens_hsa030180.83119722
68Chemical carcinogenesis_Homo sapiens_hsa052040.79992343
69Autoimmune thyroid disease_Homo sapiens_hsa053200.79602636
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79308275
71Fructose and mannose metabolism_Homo sapiens_hsa000510.79155765
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77586243
73Parkinsons disease_Homo sapiens_hsa050120.72523634
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71741858
75Systemic lupus erythematosus_Homo sapiens_hsa053220.70568958
76* Antigen processing and presentation_Homo sapiens_hsa046120.69149262
77Metabolic pathways_Homo sapiens_hsa011000.68671143
78Retinol metabolism_Homo sapiens_hsa008300.67213991
79Legionellosis_Homo sapiens_hsa051340.66169952
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65336260
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64042239
82Fatty acid degradation_Homo sapiens_hsa000710.63755813
83Sulfur metabolism_Homo sapiens_hsa009200.62606879
84Ether lipid metabolism_Homo sapiens_hsa005650.60926241
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60525782
86Oxidative phosphorylation_Homo sapiens_hsa001900.58359459
87Galactose metabolism_Homo sapiens_hsa000520.58042392
88Pyruvate metabolism_Homo sapiens_hsa006200.57961333
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56744051
90Influenza A_Homo sapiens_hsa051640.56473022
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55576108
92Tryptophan metabolism_Homo sapiens_hsa003800.54001200
93Huntingtons disease_Homo sapiens_hsa050160.53579889
94Histidine metabolism_Homo sapiens_hsa003400.51415568
95Protein export_Homo sapiens_hsa030600.49911986
96Allograft rejection_Homo sapiens_hsa053300.49056985
97Staphylococcus aureus infection_Homo sapiens_hsa051500.47120445
98N-Glycan biosynthesis_Homo sapiens_hsa005100.46400315
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46242768
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.45352814
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.45140868
102beta-Alanine metabolism_Homo sapiens_hsa004100.44241500
103HTLV-I infection_Homo sapiens_hsa051660.43439975
104Caffeine metabolism_Homo sapiens_hsa002320.42230224
105Arginine and proline metabolism_Homo sapiens_hsa003300.41840022
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.40511864
107Carbon metabolism_Homo sapiens_hsa012000.40198537
108Biosynthesis of amino acids_Homo sapiens_hsa012300.40169077
109Shigellosis_Homo sapiens_hsa051310.39861796
110Rheumatoid arthritis_Homo sapiens_hsa053230.39557480
111Fatty acid metabolism_Homo sapiens_hsa012120.39286812
112Notch signaling pathway_Homo sapiens_hsa043300.38609924
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37954278
114Sphingolipid metabolism_Homo sapiens_hsa006000.37808215
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.37628651
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37289276
117Pertussis_Homo sapiens_hsa051330.36995497
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36158279
119Bladder cancer_Homo sapiens_hsa052190.34349741
120Type I diabetes mellitus_Homo sapiens_hsa049400.33009413
121Collecting duct acid secretion_Homo sapiens_hsa049660.31928952
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26893506
123mRNA surveillance pathway_Homo sapiens_hsa030150.23406397
124Viral myocarditis_Homo sapiens_hsa054160.23396472
125Propanoate metabolism_Homo sapiens_hsa006400.23244095
126Viral carcinogenesis_Homo sapiens_hsa052030.22789264
127Apoptosis_Homo sapiens_hsa042100.21412580
128Basal cell carcinoma_Homo sapiens_hsa052170.20695728
129Lysosome_Homo sapiens_hsa041420.20418318
130Acute myeloid leukemia_Homo sapiens_hsa052210.20058613
131B cell receptor signaling pathway_Homo sapiens_hsa046620.16859709
132* Tuberculosis_Homo sapiens_hsa051520.15023023

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