RFPL3S

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)7.58294917
2multicellular organism reproduction (GO:0032504)7.39716172
3fusion of sperm to egg plasma membrane (GO:0007342)7.35221824
4regulation of cilium movement (GO:0003352)6.71221149
5rRNA methylation (GO:0031167)6.65507145
6protein polyglutamylation (GO:0018095)6.60342240
7sperm-egg recognition (GO:0035036)6.59584380
8protein targeting to Golgi (GO:0000042)6.52333924
9single strand break repair (GO:0000012)6.49643020
10binding of sperm to zona pellucida (GO:0007339)6.47975127
11establishment of protein localization to Golgi (GO:0072600)6.24059126
12epithelial cilium movement (GO:0003351)6.05717299
13rRNA modification (GO:0000154)6.00241229
14retrograde transport, vesicle recycling within Golgi (GO:0000301)5.99803684
15axonemal dynein complex assembly (GO:0070286)5.93250450
16reproduction (GO:0000003)5.77365498
17centriole replication (GO:0007099)5.76248517
18male meiosis (GO:0007140)5.68957010
19sperm capacitation (GO:0048240)5.68467466
20calcium ion-dependent exocytosis (GO:0017156)5.67297843
21plasma membrane fusion (GO:0045026)5.67029019
22cilium or flagellum-dependent cell motility (GO:0001539)5.52331642
23cell-cell recognition (GO:0009988)5.44823217
24spermatogenesis (GO:0007283)5.32994384
25single fertilization (GO:0007338)5.32283055
26male gamete generation (GO:0048232)5.32240784
27response to pheromone (GO:0019236)5.26947013
28motile cilium assembly (GO:0044458)5.20001444
29piRNA metabolic process (GO:0034587)5.14476292
30microtubule depolymerization (GO:0007019)5.10873501
31centriole assembly (GO:0098534)4.97300198
32gamete generation (GO:0007276)4.94514836
33cilium movement (GO:0003341)4.91135925
34protein localization to Golgi apparatus (GO:0034067)4.90645597
35synapsis (GO:0007129)4.80931433
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.73566293
37germ cell development (GO:0007281)4.67565431
38chromosome condensation (GO:0030261)4.63626505
39spermatid nucleus differentiation (GO:0007289)4.63030935
40seminiferous tubule development (GO:0072520)4.62343344
41microtubule polymerization or depolymerization (GO:0031109)4.58761764
42fertilization (GO:0009566)4.57426725
43DNA packaging (GO:0006323)4.53960598
44phosphatidylethanolamine biosynthetic process (GO:0006646)4.50985472
45regulation of microtubule-based movement (GO:0060632)4.48376907
46cellular ketone body metabolic process (GO:0046950)4.46726641
47microtubule severing (GO:0051013)4.45525665
48regulation of meiosis I (GO:0060631)4.45306585
49phosphatidylethanolamine metabolic process (GO:0046337)4.31176576
50microtubule nucleation (GO:0007020)4.24807997
51regulation of phosphoprotein phosphatase activity (GO:0043666)4.23088878
52RNA destabilization (GO:0050779)4.22627627
53negative regulation of inclusion body assembly (GO:0090084)4.19656135
54male meiosis I (GO:0007141)4.04521769
55cellular process involved in reproduction in multicellular organism (GO:0022412)3.98879149
56ketone body metabolic process (GO:1902224)3.93896536
57multicellular organismal reproductive process (GO:0048609)3.91298693
58chromosome organization involved in meiosis (GO:0070192)3.81921934
59organic cation transport (GO:0015695)3.81731762
60DNA methylation involved in gamete generation (GO:0043046)3.73383742
61synaptonemal complex assembly (GO:0007130)3.60011978
62regulation of centriole replication (GO:0046599)3.59171900
63synaptonemal complex organization (GO:0070193)3.49568358
64axoneme assembly (GO:0035082)3.46463959
65nonmotile primary cilium assembly (GO:0035058)3.36710054
66polyamine biosynthetic process (GO:0006596)3.34299455
67pattern specification involved in kidney development (GO:0061004)3.32238966
68oogenesis (GO:0048477)3.30344111
69meiotic nuclear division (GO:0007126)3.28185905
70response to acidic pH (GO:0010447)3.26493285
71male sex determination (GO:0030238)3.16055578
72intra-Golgi vesicle-mediated transport (GO:0006891)3.15963264
73positive regulation of Rab GTPase activity (GO:0032851)3.13777741
74regulation of Rab GTPase activity (GO:0032313)3.13777741
75nucleus organization (GO:0006997)3.01418867
76detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.99881124
77negative regulation of Rho protein signal transduction (GO:0035024)2.98281536
78histone H3-K9 demethylation (GO:0033169)2.96459724
79meiosis I (GO:0007127)2.95498050
80regulation of inclusion body assembly (GO:0090083)2.94638920
81cilium organization (GO:0044782)2.94318119
82resolution of meiotic recombination intermediates (GO:0000712)2.93165531
83cilium assembly (GO:0042384)2.91906418
84cellular biogenic amine biosynthetic process (GO:0042401)2.90152029
85acrosome assembly (GO:0001675)2.88882246
86cell wall macromolecule metabolic process (GO:0044036)2.88084329
87cell recognition (GO:0008037)2.81540962
88amine biosynthetic process (GO:0009309)2.77757102
89gonadal mesoderm development (GO:0007506)2.76904558
90meiotic cell cycle process (GO:1903046)2.74208037
91positive regulation of meiotic cell cycle (GO:0051446)2.74070082
92C4-dicarboxylate transport (GO:0015740)2.73620146
93ventricular system development (GO:0021591)2.73292784
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70167084
95DNA double-strand break processing (GO:0000729)2.69286889
96regulation of transcription involved in cell fate commitment (GO:0060850)2.69086646
97positive regulation of meiosis (GO:0045836)2.65548682
98epithelial cell fate commitment (GO:0072148)2.63207468
99sperm motility (GO:0030317)10.1717380
100acrosome reaction (GO:0007340)10.0129100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.77214505
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.80835571
3EZH2_22144423_ChIP-Seq_EOC_Human3.48629864
4ZNF274_21170338_ChIP-Seq_K562_Hela3.02946195
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.91834331
6FUS_26573619_Chip-Seq_HEK293_Human2.55775452
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.50991099
8CBP_20019798_ChIP-Seq_JUKART_Human2.50991099
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.45806374
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41576752
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39911876
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37900454
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.37900454
14VDR_22108803_ChIP-Seq_LS180_Human2.19393827
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03825394
16IGF1R_20145208_ChIP-Seq_DFB_Human1.99120254
17GBX2_23144817_ChIP-Seq_PC3_Human1.98030226
18ER_23166858_ChIP-Seq_MCF-7_Human1.92323473
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84361557
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83434002
21P300_19829295_ChIP-Seq_ESCs_Human1.81526559
22VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.81085593
23ERA_21632823_ChIP-Seq_H3396_Human1.78028043
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73162572
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66150267
26KLF5_20875108_ChIP-Seq_MESCs_Mouse1.58360873
27MYC_19829295_ChIP-Seq_ESCs_Human1.57597902
28NANOG_20526341_ChIP-Seq_ESCs_Human1.55898545
29RAC3_21632823_ChIP-Seq_H3396_Human1.53164075
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52352491
31AR_25329375_ChIP-Seq_VCAP_Human1.50723107
32SMAD4_21741376_ChIP-Seq_EPCs_Human1.49250571
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47743828
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46463103
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.45658290
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.45512928
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43237619
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41923737
39OCT4_20526341_ChIP-Seq_ESCs_Human1.39671310
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39547811
41NCOR_22424771_ChIP-Seq_293T_Human1.38114959
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.37892112
43ERG_20517297_ChIP-Seq_VCAP_Human1.37790970
44IRF1_19129219_ChIP-ChIP_H3396_Human1.36687073
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35015208
46CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.33935987
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33787628
48SOX2_19829295_ChIP-Seq_ESCs_Human1.33499301
49NANOG_19829295_ChIP-Seq_ESCs_Human1.33499301
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32828325
51SMAD4_21799915_ChIP-Seq_A2780_Human1.32207703
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31372863
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.31168938
54FOXH1_21741376_ChIP-Seq_EPCs_Human1.30296421
55RBPJ_21746931_ChIP-Seq_IB4_Human1.28236749
56STAT3_23295773_ChIP-Seq_U87_Human1.26616089
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24507575
58NFYB_21822215_ChIP-Seq_K562_Human1.23448299
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.22980166
60RUNX2_22187159_ChIP-Seq_PCA_Human1.22701957
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.22420440
62CBX2_22325352_ChIP-Seq_293T-Rex_Human1.21528726
63TBL1_22424771_ChIP-Seq_293T_Human1.20862458
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20458535
65TAF2_19829295_ChIP-Seq_ESCs_Human1.19976484
66PHF8_20622853_ChIP-Seq_HELA_Human1.18806861
67CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18635456
68ETV1_20927104_ChIP-Seq_GIST48_Human1.18634355
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16841454
70TAF15_26573619_Chip-Seq_HEK293_Human1.15803597
71HNFA_21074721_ChIP-Seq_CACO-2_Human1.14184233
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13540567
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12973301
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12573936
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.12515511
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12515511
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12191407
78REST_21632747_ChIP-Seq_MESCs_Mouse1.09900612
79SMAD3_21741376_ChIP-Seq_ESCs_Human1.09179460
80HOXB7_26014856_ChIP-Seq_BT474_Human1.09113454
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.08608082
82PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06336631
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06042976
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.05712046
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05254192
86TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04723115
87TCF4_23295773_ChIP-Seq_U87_Human1.04700579
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.03057460
89TP53_22573176_ChIP-Seq_HFKS_Human1.02588817
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01488984
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.00689076
92TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00153372
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99803137
94GATA3_26560356_Chip-Seq_TH1_Human0.99598067
95CTCF_20526341_ChIP-Seq_ESCs_Human0.99517084
96OCT1_27270436_Chip-Seq_PROSTATE_Human0.98001400
97PHF8_20622854_ChIP-Seq_HELA_Human0.97900402
98BCAT_22108803_ChIP-Seq_LS180_Human0.96990672
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.96705116
100P300_27268052_Chip-Seq_Bcells_Human0.94040198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.60441362
2MP0003698_abnormal_male_reproductive3.48055261
3MP0001929_abnormal_gametogenesis3.41481300
4MP0003878_abnormal_ear_physiology2.77649262
5MP0005377_hearing/vestibular/ear_phenot2.77649262
6MP0001984_abnormal_olfaction2.73805485
7MP0008877_abnormal_DNA_methylation2.67852375
8MP0005423_abnormal_somatic_nervous2.32961726
9MP0002210_abnormal_sex_determination2.17277107
10MP0005379_endocrine/exocrine_gland_phen2.17205040
11MP0003718_maternal_effect2.06363484
12MP0005394_taste/olfaction_phenotype1.99851198
13MP0005499_abnormal_olfactory_system1.99851198
14MP0002161_abnormal_fertility/fecundity1.97360939
15MP0003283_abnormal_digestive_organ1.96240694
16MP0005551_abnormal_eye_electrophysiolog1.88715684
17MP0008789_abnormal_olfactory_epithelium1.81870492
18MP0005670_abnormal_white_adipose1.78805117
19MP0008004_abnormal_stomach_pH1.76555807
20MP0008995_early_reproductive_senescence1.73160396
21MP0001145_abnormal_male_reproductive1.68136972
22MP0001485_abnormal_pinna_reflex1.63551198
23MP0000653_abnormal_sex_gland1.63227615
24MP0003315_abnormal_perineum_morphology1.62889534
25MP0003646_muscle_fatigue1.59142727
26MP0001486_abnormal_startle_reflex1.55519677
27MP0003880_abnormal_central_pattern1.47457967
28MP0002837_dystrophic_cardiac_calcinosis1.46165241
29MP0002102_abnormal_ear_morphology1.45823734
30MP0005646_abnormal_pituitary_gland1.44854004
31MP0001529_abnormal_vocalization1.43422910
32MP0005253_abnormal_eye_physiology1.42762204
33MP0003787_abnormal_imprinting1.41265551
34MP0001348_abnormal_lacrimal_gland1.39799369
35MP0006072_abnormal_retinal_apoptosis1.39592797
36MP0002138_abnormal_hepatobiliary_system1.37599264
37MP0002277_abnormal_respiratory_mucosa1.34971090
38MP0003136_yellow_coat_color1.32958926
39MP0009745_abnormal_behavioral_response1.31499218
40MP0002272_abnormal_nervous_system1.30560749
41MP0002557_abnormal_social/conspecific_i1.25935148
42MP0003011_delayed_dark_adaptation1.25597422
43MP0003879_abnormal_hair_cell1.23121945
44MP0002160_abnormal_reproductive_system1.22684372
45MP0001968_abnormal_touch/_nociception1.21686515
46MP0006292_abnormal_olfactory_placode1.21287479
47MP0002132_abnormal_respiratory_system1.20288190
48MP0001905_abnormal_dopamine_level1.17735627
49MP0002163_abnormal_gland_morphology1.17017748
50MP0005310_abnormal_salivary_gland1.13164831
51MP0008058_abnormal_DNA_repair1.12961803
52MP0001873_stomach_inflammation1.10216484
53MP0010386_abnormal_urinary_bladder1.07214341
54MP0005360_urolithiasis1.06429629
55MP0002572_abnormal_emotion/affect_behav1.05807281
56MP0003890_abnormal_embryonic-extraembry1.02942325
57MP0006276_abnormal_autonomic_nervous1.02683404
58MP0005248_abnormal_Harderian_gland0.97974213
59MP0002735_abnormal_chemical_nociception0.97146081
60MP0005645_abnormal_hypothalamus_physiol0.96562295
61MP0001501_abnormal_sleep_pattern0.95254336
62MP0001963_abnormal_hearing_physiology0.91982647
63MP0000955_abnormal_spinal_cord0.90833956
64MP0000026_abnormal_inner_ear0.90436854
65MP0004142_abnormal_muscle_tone0.89798853
66MP0009046_muscle_twitch0.89409870
67MP0004859_abnormal_synaptic_plasticity0.88745568
68MP0005647_abnormal_sex_gland0.88705827
69MP0005389_reproductive_system_phenotype0.87590856
70MP0003635_abnormal_synaptic_transmissio0.87478991
71MP0002229_neurodegeneration0.87414491
72MP0002638_abnormal_pupillary_reflex0.86477623
73MP0002822_catalepsy0.86055732
74MP0005187_abnormal_penis_morphology0.85672831
75MP0002063_abnormal_learning/memory/cond0.83703035
76MP0002067_abnormal_sensory_capabilities0.83576405
77MP0001970_abnormal_pain_threshold0.82382972
78MP0005167_abnormal_blood-brain_barrier0.82252239
79MP0002184_abnormal_innervation0.81928991
80MP0002064_seizures0.80407771
81MP0004742_abnormal_vestibular_system0.80014500
82MP0001765_abnormal_ion_homeostasis0.79172442
83MP0001944_abnormal_pancreas_morphology0.78144594
84MP0000372_irregular_coat_pigmentation0.77399679
85MP0001919_abnormal_reproductive_system0.76491595
86MP0002282_abnormal_trachea_morphology0.76419083
87MP0004133_heterotaxia0.75293538
88MP0000678_abnormal_parathyroid_gland0.73226186
89MP0001986_abnormal_taste_sensitivity0.72880968
90MP0004085_abnormal_heartbeat0.72718943
91MP0008872_abnormal_physiological_respon0.72268352
92MP0005636_abnormal_mineral_homeostasis0.70946176
93MP0003633_abnormal_nervous_system0.70637175
94MP0005395_other_phenotype0.70043721
95MP0002734_abnormal_mechanical_nocicepti0.69928787
96MP0002733_abnormal_thermal_nociception0.68616512
97MP0003936_abnormal_reproductive_system0.67751743
98MP0002752_abnormal_somatic_nervous0.67694516
99MP0006036_abnormal_mitochondrial_physio0.65951436
100MP0001502_abnormal_circadian_rhythm0.65837386

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)5.35884382
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.35884382
3Resting tremor (HP:0002322)4.57738089
4Tubulointerstitial nephritis (HP:0001970)4.47440802
5Abnormal rod and cone electroretinograms (HP:0008323)4.46770254
6Severe visual impairment (HP:0001141)4.39862899
7Chronic hepatic failure (HP:0100626)4.28366062
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.23800667
9Abnormal respiratory motile cilium morphology (HP:0005938)4.17828452
10Abnormal respiratory epithelium morphology (HP:0012253)4.17828452
11Abnormal ciliary motility (HP:0012262)4.14354190
12Abnormal respiratory motile cilium physiology (HP:0012261)4.07205878
13Attenuation of retinal blood vessels (HP:0007843)3.93607237
14Infertility (HP:0000789)3.71161761
15Bony spicule pigmentary retinopathy (HP:0007737)3.61596380
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.45651145
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.27667338
18Nephronophthisis (HP:0000090)3.22979647
19Type II lissencephaly (HP:0007260)3.03180474
20Progressive cerebellar ataxia (HP:0002073)2.89840056
21Type 2 muscle fiber atrophy (HP:0003554)2.89095012
22Medial flaring of the eyebrow (HP:0010747)2.83851649
23Postural instability (HP:0002172)2.81505305
24Congenital sensorineural hearing impairment (HP:0008527)2.80280954
25Rhinitis (HP:0012384)2.76836899
26Nasal polyposis (HP:0100582)2.69377561
27Impulsivity (HP:0100710)2.66037085
28Hypoplasia of the uterus (HP:0000013)2.65175248
29Abnormality of dental color (HP:0011073)2.64912901
30Pancreatic fibrosis (HP:0100732)2.64439344
31Abnormality of macular pigmentation (HP:0008002)2.62446596
32Pancreatic cysts (HP:0001737)2.53303549
33Sex reversal (HP:0012245)2.52299809
34Abnormal sex determination (HP:0012244)2.52299809
35Abnormality of the renal medulla (HP:0100957)2.51723961
36Muscle fiber atrophy (HP:0100295)2.50647193
37Asymmetric septal hypertrophy (HP:0001670)2.49623720
38Male infertility (HP:0003251)2.47817867
39Polydipsia (HP:0001959)2.40417357
40Abnormal drinking behavior (HP:0030082)2.40417357
41Cone-rod dystrophy (HP:0000548)2.35743493
42Aplasia/Hypoplasia of the earlobes (HP:0009906)2.33697996
43Aplasia/hypoplasia of the uterus (HP:0008684)2.32697537
44Male pseudohermaphroditism (HP:0000037)2.31107757
45Gait imbalance (HP:0002141)2.28949318
46Congenital primary aphakia (HP:0007707)2.27979927
47Amelogenesis imperfecta (HP:0000705)2.21513649
48Dyschromatopsia (HP:0007641)2.19211507
49Intestinal atresia (HP:0011100)2.16450013
50Tubulointerstitial abnormality (HP:0001969)2.16408524
51True hermaphroditism (HP:0010459)2.15410116
52Nephrogenic diabetes insipidus (HP:0009806)2.12509051
53Azoospermia (HP:0000027)2.10859039
54Occipital encephalocele (HP:0002085)2.09361132
55Cerebellar dysplasia (HP:0007033)2.09098746
56Atonic seizures (HP:0010819)2.07089829
57Hyperkalemia (HP:0002153)2.05595538
58Bronchiectasis (HP:0002110)2.04793946
59Optic nerve hypoplasia (HP:0000609)2.04424156
60Tubular atrophy (HP:0000092)2.03900390
61Bile duct proliferation (HP:0001408)2.02196431
62Abnormal biliary tract physiology (HP:0012439)2.02196431
63Poor coordination (HP:0002370)2.00974715
64Abnormality of the nasal mucosa (HP:0000433)1.99860318
65Retinal dysplasia (HP:0007973)1.98684881
66Stage 5 chronic kidney disease (HP:0003774)1.98376735
67Decreased central vision (HP:0007663)1.97656065
68Congenital stationary night blindness (HP:0007642)1.97117944
69Abnormal spermatogenesis (HP:0008669)1.94926141
70Abnormality of the aortic arch (HP:0012303)1.94812021
71Generalized aminoaciduria (HP:0002909)1.92976049
72Hypoalphalipoproteinemia (HP:0003233)1.89705715
73Photophobia (HP:0000613)1.89325428
74Genital tract atresia (HP:0001827)1.87975622
75Abnormal albumin level (HP:0012116)1.87806842
76Hypoalbuminemia (HP:0003073)1.87806842
77Limb dystonia (HP:0002451)1.87520534
78Anencephaly (HP:0002323)1.87024920
79Abnormality of midbrain morphology (HP:0002418)1.86914099
80Molar tooth sign on MRI (HP:0002419)1.86914099
81Truncal obesity (HP:0001956)1.86912543
82Poor suck (HP:0002033)1.86006373
83Lissencephaly (HP:0001339)1.85940559
84Sensory axonal neuropathy (HP:0003390)1.83874010
85Congenital malformation of the right heart (HP:0011723)1.83495723
86Double outlet right ventricle (HP:0001719)1.83495723
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83152670
88Anterior segment dysgenesis (HP:0007700)1.80563522
89Polyuria (HP:0000103)1.80080590
90Cystic liver disease (HP:0006706)1.80020570
91Abolished electroretinogram (ERG) (HP:0000550)1.79504977
92Type II diabetes mellitus (HP:0005978)1.79175070
93Gastrointestinal atresia (HP:0002589)1.78407758
94Renal Fanconi syndrome (HP:0001994)1.77456048
95Menstrual irregularities (HP:0000858)1.76526506
96Abnormal urine output (HP:0012590)1.75797690
97Insulin-resistant diabetes mellitus (HP:0000831)1.74645972
98Vaginal atresia (HP:0000148)1.74072136
99Abnormality of urine glucose concentration (HP:0011016)1.72716316
100Glycosuria (HP:0003076)1.72716316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.53314141
2PINK14.85414778
3INSRR3.47570350
4MAP4K23.41452167
5MARK33.00120033
6BRD42.84761058
7TXK2.50406323
8PLK22.49096351
9ZAK2.43572297
10TYRO32.23045597
11STK382.10359830
12FRK2.08681406
13STK38L1.93042373
14TAOK31.79878628
15ACVR1B1.69341229
16BMPR1B1.69102915
17PNCK1.65669441
18MAPK151.54637266
19TLK11.53868836
20MAP3K91.53800350
21SIK21.53557551
22MAP3K41.39314035
23PRKCG1.20608714
24CAMK1G1.18734536
25MAP2K71.16502123
26SIK31.16460290
27NEK61.15487848
28NTRK31.10067611
29SGK2231.08922218
30SGK4941.08922218
31TESK11.05029760
32ADRBK20.99236781
33WNK30.99220584
34TIE10.95865618
35WNK40.89545586
36CASK0.88752172
37CDK30.87268634
38STK390.81586474
39GRK10.81428560
40DYRK1B0.81272666
41RPS6KA50.80697555
42SGK20.79209022
43PIK3CG0.78886242
44DDR20.76013629
45PDK10.75182734
46WNK10.74220280
47PRKD30.73527524
48TNIK0.72596928
49MAP2K60.67853165
50PRKCQ0.66967944
51DYRK20.66514508
52BRAF0.64190177
53CAMK10.62332837
54EPHA40.58564059
55TRIM280.53696816
56EIF2AK30.53392131
57PDPK10.52025973
58MARK10.51714099
59PRKG10.51616212
60CSNK1G30.51229683
61PAK30.51213202
62LATS20.49587647
63PTK2B0.48226144
64MAP3K130.47941823
65CSNK1A1L0.46832497
66NTRK20.46235050
67CSNK1G20.46098661
68CDK80.45642667
69DYRK30.45576407
70CSNK1G10.44780583
71BCKDK0.44660736
72ARAF0.42405015
73MAPKAPK30.42160796
74TGFBR10.41514477
75PRKCZ0.41412197
76MAP3K50.39539686
77MAPK130.38335280
78RPS6KA10.37984401
79VRK10.36701585
80KSR20.34650082
81ATM0.34573096
82SGK10.34547134
83CSNK1A10.34068673
84PLK10.33702944
85OXSR10.33587890
86NEK20.32371163
87PKN10.31615075
88MAPK10.31430989
89CAMK1D0.31411494
90FGFR20.30124557
91TAOK10.30046838
92CHUK0.29684396
93GSK3B0.29392441
94STK160.28891057
95PRKAA10.28733075
96RPS6KB10.28202720
97TNK20.28199899
98STK30.27487035
99PRKACA0.27168709
100LMTK20.27141183

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.55491011
2Olfactory transduction_Homo sapiens_hsa047403.38388039
3Butanoate metabolism_Homo sapiens_hsa006503.12998161
4Fatty acid biosynthesis_Homo sapiens_hsa000612.75301153
5Basal transcription factors_Homo sapiens_hsa030222.45900765
6Phototransduction_Homo sapiens_hsa047442.25101522
7Dorso-ventral axis formation_Homo sapiens_hsa043202.24842794
8RNA transport_Homo sapiens_hsa030132.11236391
9Regulation of autophagy_Homo sapiens_hsa041401.94106643
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87689876
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.87238215
12Nicotine addiction_Homo sapiens_hsa050331.80904778
13Nitrogen metabolism_Homo sapiens_hsa009101.80730217
14Synaptic vesicle cycle_Homo sapiens_hsa047211.79448856
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.75762782
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75155815
17Circadian rhythm_Homo sapiens_hsa047101.74165137
18Fanconi anemia pathway_Homo sapiens_hsa034601.65318185
19Taste transduction_Homo sapiens_hsa047421.57654737
20Protein export_Homo sapiens_hsa030601.53849779
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.50451953
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48776445
23Oxidative phosphorylation_Homo sapiens_hsa001901.48005696
24Hedgehog signaling pathway_Homo sapiens_hsa043401.44756696
25Linoleic acid metabolism_Homo sapiens_hsa005911.38056833
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34435953
27RNA degradation_Homo sapiens_hsa030181.33648652
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32654253
29Collecting duct acid secretion_Homo sapiens_hsa049661.31427493
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29031746
31Propanoate metabolism_Homo sapiens_hsa006401.27714076
32Gap junction_Homo sapiens_hsa045401.20354575
33Oocyte meiosis_Homo sapiens_hsa041141.15372068
34ABC transporters_Homo sapiens_hsa020101.13040563
35Cardiac muscle contraction_Homo sapiens_hsa042601.12169610
36Huntingtons disease_Homo sapiens_hsa050161.10684201
37Fatty acid metabolism_Homo sapiens_hsa012121.09905535
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03190837
39Type I diabetes mellitus_Homo sapiens_hsa049401.02848250
40Morphine addiction_Homo sapiens_hsa050321.02331359
41Parkinsons disease_Homo sapiens_hsa050120.96491893
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91495171
43Fatty acid degradation_Homo sapiens_hsa000710.88000869
44Insulin secretion_Homo sapiens_hsa049110.86004134
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85444437
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84917752
47GABAergic synapse_Homo sapiens_hsa047270.82391443
48Non-homologous end-joining_Homo sapiens_hsa034500.81755467
49Glutamatergic synapse_Homo sapiens_hsa047240.78156821
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77379034
51mRNA surveillance pathway_Homo sapiens_hsa030150.77200272
52Phagosome_Homo sapiens_hsa041450.71731242
53Tryptophan metabolism_Homo sapiens_hsa003800.70609238
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66438147
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65973464
56Circadian entrainment_Homo sapiens_hsa047130.65901550
57Oxytocin signaling pathway_Homo sapiens_hsa049210.63295127
58Sulfur relay system_Homo sapiens_hsa041220.61854586
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.60824699
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.60099801
61cAMP signaling pathway_Homo sapiens_hsa040240.58536125
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58212093
63T cell receptor signaling pathway_Homo sapiens_hsa046600.55209988
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52540698
65Phenylalanine metabolism_Homo sapiens_hsa003600.52052380
66Metabolic pathways_Homo sapiens_hsa011000.51015991
67Chemical carcinogenesis_Homo sapiens_hsa052040.48618276
68Purine metabolism_Homo sapiens_hsa002300.48362320
69Serotonergic synapse_Homo sapiens_hsa047260.47947758
70Retinol metabolism_Homo sapiens_hsa008300.47734456
71MAPK signaling pathway_Homo sapiens_hsa040100.46925417
72Calcium signaling pathway_Homo sapiens_hsa040200.46348073
73Salivary secretion_Homo sapiens_hsa049700.44670332
74Alzheimers disease_Homo sapiens_hsa050100.43750436
75beta-Alanine metabolism_Homo sapiens_hsa004100.43418258
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43148010
77RNA polymerase_Homo sapiens_hsa030200.43070415
78Arachidonic acid metabolism_Homo sapiens_hsa005900.42368294
79Peroxisome_Homo sapiens_hsa041460.42365931
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42360280
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40544885
82Homologous recombination_Homo sapiens_hsa034400.39647465
83Legionellosis_Homo sapiens_hsa051340.39456562
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.38605296
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38597823
86Cholinergic synapse_Homo sapiens_hsa047250.38199974
87Selenocompound metabolism_Homo sapiens_hsa004500.37230844
88Allograft rejection_Homo sapiens_hsa053300.36819621
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34973275
90Renin secretion_Homo sapiens_hsa049240.33745017
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33500676
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31650389
93Amphetamine addiction_Homo sapiens_hsa050310.31617810
94Fatty acid elongation_Homo sapiens_hsa000620.31408065
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30518248
96Glycerolipid metabolism_Homo sapiens_hsa005610.30146460
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29234874
98Alcoholism_Homo sapiens_hsa050340.29200312
99Rheumatoid arthritis_Homo sapiens_hsa053230.28812284
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28197695

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