RFK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)7.09238431
2intestinal cholesterol absorption (GO:0030299)6.31908663
3Golgi transport vesicle coating (GO:0048200)5.51085505
4COPI coating of Golgi vesicle (GO:0048205)5.51085505
5purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.09324339
63-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.09324339
7UDP-N-acetylglucosamine metabolic process (GO:0006047)4.99508971
8angiotensin maturation (GO:0002003)4.94693467
9flavonoid metabolic process (GO:0009812)4.42234025
10peptide hormone processing (GO:0016486)4.30381408
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.01960267
12protein retention in ER lumen (GO:0006621)3.99156157
13COPII vesicle coating (GO:0048208)3.93040414
14nucleotide-sugar biosynthetic process (GO:0009226)3.90028819
15maintenance of gastrointestinal epithelium (GO:0030277)3.86948642
16drug catabolic process (GO:0042737)3.84551027
17digestive system process (GO:0022600)3.84430610
18endocrine pancreas development (GO:0031018)3.78509436
19intestinal epithelial cell development (GO:0060576)3.72311659
20digestion (GO:0007586)3.69590182
21modified amino acid transport (GO:0072337)3.69067701
22signal peptide processing (GO:0006465)3.66108901
23bundle of His cell to Purkinje myocyte communication (GO:0086069)3.59987261
24positive regulation of mitochondrial fission (GO:0090141)3.57144087
25regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.55454281
26hormone catabolic process (GO:0042447)3.52246342
27NADH metabolic process (GO:0006734)3.49357243
28synaptic vesicle maturation (GO:0016188)3.48067311
29regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.40237669
30nucleobase catabolic process (GO:0046113)3.40036066
31GDP-mannose metabolic process (GO:0019673)3.39033829
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38031978
33glandular epithelial cell differentiation (GO:0002067)3.37533424
34regulation of mitochondrial translation (GO:0070129)3.36467254
35peptide catabolic process (GO:0043171)3.36157467
36glucuronate metabolic process (GO:0019585)3.35847545
37uronic acid metabolic process (GO:0006063)3.35847545
38cysteine metabolic process (GO:0006534)3.35480397
39nucleoside diphosphate biosynthetic process (GO:0009133)3.34744501
40cellular glucuronidation (GO:0052695)3.34380947
41sulfur amino acid catabolic process (GO:0000098)3.33672880
42negative regulation of digestive system process (GO:0060457)3.33200043
43nucleotide-sugar metabolic process (GO:0009225)3.30475025
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27343565
45positive regulation of triglyceride lipase activity (GO:0061365)3.23852531
46positive regulation of lipoprotein lipase activity (GO:0051006)3.23852531
47regulation of cholesterol homeostasis (GO:2000188)3.22921062
48drug transport (GO:0015893)3.21831352
49drug transmembrane transport (GO:0006855)3.20855336
50protein localization to cilium (GO:0061512)3.17300759
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16751760
52bile acid and bile salt transport (GO:0015721)3.15688899
53L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15534851
54sulfate transmembrane transport (GO:1902358)3.14491956
55positive regulation of fatty acid biosynthetic process (GO:0045723)3.14451090
56establishment of mitochondrion localization (GO:0051654)3.12996342
57xenobiotic catabolic process (GO:0042178)3.12211400
58sulfation (GO:0051923)3.08805763
59membrane budding (GO:0006900)3.06743914
60O-glycan processing (GO:0016266)3.04137571
61calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.03940658
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03524648
63glutamate secretion (GO:0014047)3.02904794
64ribonucleoprotein complex disassembly (GO:0032988)3.01740414
65pyrimidine-containing compound transmembrane transport (GO:0072531)2.96462512
66folic acid transport (GO:0015884)2.95213112
67sulfur compound transport (GO:0072348)2.94951856
68thyroid hormone metabolic process (GO:0042403)2.93011103
69pyrimidine nucleobase catabolic process (GO:0006208)2.91724495
70positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.91195409
71mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.91195409
72protein deneddylation (GO:0000338)2.90454029
73vitamin A metabolic process (GO:0006776)2.90006441
74transcytosis (GO:0045056)2.89929683
75cullin deneddylation (GO:0010388)2.89191513
76regulation of cholesterol biosynthetic process (GO:0045540)2.87180432
77respiratory electron transport chain (GO:0022904)2.84133861
78polyketide metabolic process (GO:0030638)2.83079534
79doxorubicin metabolic process (GO:0044598)2.83079534
80daunorubicin metabolic process (GO:0044597)2.83079534
81proteasome assembly (GO:0043248)2.82878868
82ubiquinone metabolic process (GO:0006743)2.82798388
83peptide metabolic process (GO:0006518)2.81395665
84regulation of cholesterol esterification (GO:0010872)2.80662798
85amino acid salvage (GO:0043102)2.80352355
86L-methionine salvage (GO:0071267)2.80352355
87L-methionine biosynthetic process (GO:0071265)2.80352355
88electron transport chain (GO:0022900)2.80043453
89energy coupled proton transport, down electrochemical gradient (GO:0015985)2.79657002
90ATP synthesis coupled proton transport (GO:0015986)2.79657002
91actin filament depolymerization (GO:0030042)2.79641184
92vitamin transport (GO:0051180)2.79249522
93regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78407851
94chaperone-mediated protein transport (GO:0072321)2.77764462
95purine nucleoside bisphosphate metabolic process (GO:0034032)2.77258663
96ribonucleoside bisphosphate metabolic process (GO:0033875)2.77258663
97nucleoside bisphosphate metabolic process (GO:0033865)2.77258663
98negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76788140
99gamma-aminobutyric acid transport (GO:0015812)2.75968703
100nucleotide transmembrane transport (GO:1901679)2.75007648
101regulation of short-term neuronal synaptic plasticity (GO:0048172)2.73666523
102ATP hydrolysis coupled proton transport (GO:0015991)2.73507353
103energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.73507353
104ubiquinone biosynthetic process (GO:0006744)2.73385984
105mitochondrial calcium ion transport (GO:0006851)2.72542579
106fatty acid beta-oxidation (GO:0006635)2.72479418
107protein-cofactor linkage (GO:0018065)2.72220294
108quinone biosynthetic process (GO:1901663)2.69598994
109protein localization to synapse (GO:0035418)2.69012033
110regulation of cholesterol metabolic process (GO:0090181)2.68411594
111renal absorption (GO:0070293)2.68297051
112establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67848716
113mitochondrion transport along microtubule (GO:0047497)2.67848716
114fatty acid oxidation (GO:0019395)2.67679952
115antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67468428
116antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67468428
117neurotransmitter secretion (GO:0007269)2.65828929
118phenylpropanoid metabolic process (GO:0009698)2.65634103
119glutathione derivative biosynthetic process (GO:1901687)2.65022464
120glutathione derivative metabolic process (GO:1901685)2.65022464
121sulfate transport (GO:0008272)2.64634120
122lysine metabolic process (GO:0006553)2.64309216
123lysine catabolic process (GO:0006554)2.64309216
124positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64215173
125tricarboxylic acid cycle (GO:0006099)2.63274749
126organelle disassembly (GO:1903008)2.63166692
127phospholipid efflux (GO:0033700)2.62531694
128quinone metabolic process (GO:1901661)2.62313835
129positive regulation of triglyceride metabolic process (GO:0090208)2.60858364
130lipid oxidation (GO:0034440)2.60675088
131exogenous drug catabolic process (GO:0042738)2.60391988
132tricarboxylic acid metabolic process (GO:0072350)2.59768742
133triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.58603312
134negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58301551
135aminoglycoside antibiotic metabolic process (GO:0030647)2.58073590
136positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.57636991
137establishment of protein localization to mitochondrial membrane (GO:0090151)2.57538122
138protein autoprocessing (GO:0016540)2.57335013
139fructose metabolic process (GO:0006000)2.56919630
140fatty acid catabolic process (GO:0009062)2.56575263
141ER overload response (GO:0006983)2.54262793
142behavioral response to nicotine (GO:0035095)2.54146943
143drug metabolic process (GO:0017144)2.54095350
144alkaloid metabolic process (GO:0009820)2.53855694
145regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.53730433
146regulation of triglyceride catabolic process (GO:0010896)2.53198927
147synaptic vesicle exocytosis (GO:0016079)2.53044104
148hepatocyte apoptotic process (GO:0097284)2.52698786
149protein maturation by protein folding (GO:0022417)2.50721627
150peptidyl-histidine modification (GO:0018202)2.50687536
151succinate metabolic process (GO:0006105)2.49973505
152regulation of guanylate cyclase activity (GO:0031282)2.49509402
153epithelial structure maintenance (GO:0010669)2.49169445
154iron-sulfur cluster assembly (GO:0016226)2.45142881
155metallo-sulfur cluster assembly (GO:0031163)2.45142881
156proline transport (GO:0015824)2.44125881
157neurofilament cytoskeleton organization (GO:0060052)2.42710987
158righting reflex (GO:0060013)2.42024287
159protein complex biogenesis (GO:0070271)2.40435862
160negative regulation of membrane potential (GO:0045837)2.37773208
161neuron cell-cell adhesion (GO:0007158)2.35823493
162positive regulation of potassium ion transmembrane transport (GO:1901381)2.35043726
163respiratory chain complex IV assembly (GO:0008535)2.34768238
164positive regulation of guanylate cyclase activity (GO:0031284)2.34727946
165positive regulation of TOR signaling (GO:0032008)2.34442174
166DNA damage response, detection of DNA damage (GO:0042769)2.33228607
167hydrogen ion transmembrane transport (GO:1902600)2.30901032
168glycoside metabolic process (GO:0016137)2.30525548
169transferrin transport (GO:0033572)2.30455708
170regulation of cellular respiration (GO:0043457)2.30369282
171peroxisome fission (GO:0016559)2.28890975
172cellular ketone body metabolic process (GO:0046950)2.28704310
173magnesium ion transport (GO:0015693)2.28337479
174deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.27959283
175mitochondrial respiratory chain complex assembly (GO:0033108)2.27697184
176regulation of synaptic vesicle exocytosis (GO:2000300)2.26977208
177neurotransmitter transport (GO:0006836)2.26910077
178regulation of cofactor metabolic process (GO:0051193)2.25455195
179regulation of coenzyme metabolic process (GO:0051196)2.25455195
180regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.25420610
181mitochondrial respiratory chain complex I assembly (GO:0032981)2.22781852
182NADH dehydrogenase complex assembly (GO:0010257)2.22781852
183mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.22781852
184behavioral response to ethanol (GO:0048149)2.22499268
185regulation of mitochondrial fission (GO:0090140)2.22087442
1862-deoxyribonucleotide biosynthetic process (GO:0009265)2.21476393
187deoxyribose phosphate biosynthetic process (GO:0046385)2.21476393
188anterograde axon cargo transport (GO:0008089)2.20401329
189inositol phosphate catabolic process (GO:0071545)2.19258460
190proton transport (GO:0015992)2.17964220
191response to pheromone (GO:0019236)2.17484250
192hydrogen transport (GO:0006818)2.16803375
193de novo posttranslational protein folding (GO:0051084)2.16517227
194protein localization to mitochondrion (GO:0070585)2.16248053
195regulation of acyl-CoA biosynthetic process (GO:0050812)2.15623370
196fucose catabolic process (GO:0019317)2.15139963
197L-fucose metabolic process (GO:0042354)2.15139963
198L-fucose catabolic process (GO:0042355)2.15139963
199regulation of neurotransmitter levels (GO:0001505)2.14721413
200nonmotile primary cilium assembly (GO:0035058)2.14380244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.77643364
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.09802002
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.03148173
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.90276680
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.81426150
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.79526113
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.41522311
8IGF1R_20145208_ChIP-Seq_DFB_Human3.41518484
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.15277356
10* LXR_22158963_ChIP-Seq_LIVER_Mouse3.15118561
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.03262918
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.94138394
13GATA4_25053715_ChIP-Seq_YYC3_Human2.86511981
14ZNF274_21170338_ChIP-Seq_K562_Hela2.85861257
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.78544222
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.65307234
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.62997571
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.58141453
19SOX2_20726797_ChIP-Seq_SW620_Human2.57388049
20ZNF263_19887448_ChIP-Seq_K562_Human2.56081927
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50196737
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47386621
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.45816470
24TAF15_26573619_Chip-Seq_HEK293_Human2.39936577
25VDR_22108803_ChIP-Seq_LS180_Human2.33124921
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33124519
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32180778
28GATA6_25053715_ChIP-Seq_YYC3_Human2.24894006
29EGR1_23403033_ChIP-Seq_LIVER_Mouse2.20631011
30GATA1_22025678_ChIP-Seq_K562_Human2.18175870
31CLOCK_20551151_ChIP-Seq_293T_Human2.14089164
32GBX2_23144817_ChIP-Seq_PC3_Human2.11294682
33ESR1_21235772_ChIP-Seq_MCF-7_Human2.09770783
34ETS1_20019798_ChIP-Seq_JURKAT_Human2.07722459
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04961040
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02051938
37ESR2_21235772_ChIP-Seq_MCF-7_Human2.01696037
38FUS_26573619_Chip-Seq_HEK293_Human2.01443061
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.99360218
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98145548
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95043371
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.91545150
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.89323100
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89185193
45* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87729672
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85884406
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78644834
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78400267
49DCP1A_22483619_ChIP-Seq_HELA_Human1.77529963
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76888605
51ELK1_19687146_ChIP-ChIP_HELA_Human1.76404726
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74924739
53* EWS_26573619_Chip-Seq_HEK293_Human1.74678811
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73182951
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.71193714
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.67978326
57FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.65838470
58* P300_19829295_ChIP-Seq_ESCs_Human1.64814496
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63430423
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59817196
61RNF2_27304074_Chip-Seq_NSC_Mouse1.59045053
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59031029
63VDR_23849224_ChIP-Seq_CD4+_Human1.58062829
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57063940
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53763951
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.51696504
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50911767
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.50591145
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50440702
70TP53_22573176_ChIP-Seq_HFKS_Human1.49543504
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.49210182
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48508410
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48304400
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46497261
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45606004
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45478953
77REST_21632747_ChIP-Seq_MESCs_Mouse1.44686058
78ATF3_27146783_Chip-Seq_COLON_Human1.43928694
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.43065564
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41073533
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39734066
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37439893
83* FOXA1_25552417_ChIP-Seq_VCAP_Human1.36926372
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.36865202
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36280545
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36092961
87GABP_19822575_ChIP-Seq_HepG2_Human1.35553552
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.34646680
89IRF1_19129219_ChIP-ChIP_H3396_Human1.34596622
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.34179164
91GATA3_24758297_ChIP-Seq_MCF-7_Human1.33994119
92* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33565277
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32208415
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32121298
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31203985
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30658201
97RACK7_27058665_Chip-Seq_MCF-7_Human1.30635992
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29702078
99CBP_20019798_ChIP-Seq_JUKART_Human1.29527614
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29527614
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.28297847
102* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27155327
103MYC_18940864_ChIP-ChIP_HL60_Human1.25557652
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25413691
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25334105
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24492163
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.22095759
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21912011
109NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21590386
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19763956
111TTF2_22483619_ChIP-Seq_HELA_Human1.19265756
112FOXO3_23340844_ChIP-Seq_DLD1_Human1.18870504
113SMAD4_21799915_ChIP-Seq_A2780_Human1.18515673
114KLF5_25053715_ChIP-Seq_YYC3_Human1.17469341
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16472895
116REST_19997604_ChIP-ChIP_NEURONS_Mouse1.14443467
117GATA1_19941826_ChIP-Seq_K562_Human1.12759686
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12534536
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11243545
120HTT_18923047_ChIP-ChIP_STHdh_Human1.11174727
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.09429728
122ER_23166858_ChIP-Seq_MCF-7_Human1.08830134
123JUN_21703547_ChIP-Seq_K562_Human1.08537061
124ERG_20517297_ChIP-Seq_VCAP_Human1.08437365
125* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07214342
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07183501
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05477140
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05342927
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03890768
130SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03589733
131HNF4A_19822575_ChIP-Seq_HepG2_Human1.03305368
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02996497
133AR_25329375_ChIP-Seq_VCAP_Human1.02881631
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01393996
135* GATA2_19941826_ChIP-Seq_K562_Human1.01107748
136* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00336171
137FOXP3_21729870_ChIP-Seq_TREG_Human1.00009821
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99259939
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.98575398
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97633601
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97524180
142* STAT3_23295773_ChIP-Seq_U87_Human0.97452766
143* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96599324
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.96347968
145TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95654343
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94348352
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94018516
148TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93672812
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93361781
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92485451
151NCOR_22424771_ChIP-Seq_293T_Human0.92106471
152* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91855141
153KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91254231
154SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90956826
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90273164
156POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90179489
157BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89903376
158AR_21909140_ChIP-Seq_LNCAP_Human0.89833420
159EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89526344
160ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89285627
161TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89178577
162AR_20517297_ChIP-Seq_VCAP_Human0.89069477
163XRN2_22483619_ChIP-Seq_HELA_Human0.87948042
164SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87936377
165P53_22387025_ChIP-Seq_ESCs_Mouse0.87318209
166KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86967051
167TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86618570
168TCF4_22108803_ChIP-Seq_LS180_Human0.86376779
169CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85879777
170AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85785777
171CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85331719
172FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84544967
173CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84475454
174GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84303369
175* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82584426
176CREB1_26743006_Chip-Seq_LNCaP_Human0.82381038
177THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81904836
178CHD1_26751641_Chip-Seq_LNCaP_Human0.80522234
179NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80425263
180SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78366233
181SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78108199
182* RARA_24833708_ChIP-Seq_LIVER_Mouse0.77038019
183JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76940698
184ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76420624
185GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75490183
186GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74879856
187ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.74657191
188ELK1_22589737_ChIP-Seq_MCF10A_Human0.74384243
189GATA2_21666600_ChIP-Seq_HMVEC_Human0.71304532
190BCOR_27268052_Chip-Seq_Bcells_Human0.71171471
191TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70552884
192GATA1_19941827_ChIP-Seq_MEL_Mouse0.67636105
193SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67593632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.44879296
2MP0002139_abnormal_hepatobiliary_system4.91505912
3MP0001666_abnormal_nutrient_absorption4.38809058
4MP0008875_abnormal_xenobiotic_pharmacok3.86253952
5MP0005365_abnormal_bile_salt3.35243680
6MP0009840_abnormal_foam_cell3.34543956
7MP0001529_abnormal_vocalization3.31383924
8MP0004043_abnormal_pH_regulation3.25623575
9MP0005085_abnormal_gallbladder_physiolo3.23009441
10MP0004264_abnormal_extraembryonic_tissu2.94656984
11MP0010234_abnormal_vibrissa_follicle2.90647284
12MP0003880_abnormal_central_pattern2.77688070
13MP0004270_analgesia2.62579991
14MP0009046_muscle_twitch2.49188452
15MP0003183_abnormal_peptide_metabolism2.48178203
16MP0004859_abnormal_synaptic_plasticity2.45242086
17MP0002877_abnormal_melanocyte_morpholog2.38978314
18MP0000462_abnormal_digestive_system2.16385329
19MP0010329_abnormal_lipoprotein_level2.15081047
20MP0001188_hyperpigmentation2.13687835
21MP0003806_abnormal_nucleotide_metabolis2.12450623
22MP0009643_abnormal_urine_homeostasis2.09475068
23MP0003252_abnormal_bile_duct2.08729104
24MP0006276_abnormal_autonomic_nervous2.06132867
25MP0004019_abnormal_vitamin_homeostasis2.04382744
26MP0009745_abnormal_behavioral_response2.02969599
27MP0003195_calcinosis2.00878077
28MP0005084_abnormal_gallbladder_morpholo2.00432829
29MP0003283_abnormal_digestive_organ1.96197053
30MP0004147_increased_porphyrin_level1.93936904
31MP0009697_abnormal_copulation1.93860006
32MP0005377_hearing/vestibular/ear_phenot1.93004284
33MP0003878_abnormal_ear_physiology1.93004284
34MP0002064_seizures1.91752003
35MP0003866_abnormal_defecation1.89566386
36MP0003635_abnormal_synaptic_transmissio1.88033735
37MP0003191_abnormal_cellular_cholesterol1.87246658
38MP0003122_maternal_imprinting1.80921166
39MP0005332_abnormal_amino_acid1.79970247
40MP0002272_abnormal_nervous_system1.77419644
41MP0002138_abnormal_hepatobiliary_system1.74988689
42MP0005636_abnormal_mineral_homeostasis1.68772408
43MP0003787_abnormal_imprinting1.67071309
44MP0002693_abnormal_pancreas_physiology1.65398496
45MP0008789_abnormal_olfactory_epithelium1.61867970
46MP0002063_abnormal_learning/memory/cond1.60004424
47MP0001905_abnormal_dopamine_level1.58975379
48MP0002572_abnormal_emotion/affect_behav1.58541931
49MP0005645_abnormal_hypothalamus_physiol1.57227064
50MP0001765_abnormal_ion_homeostasis1.53703066
51MP0001944_abnormal_pancreas_morphology1.51994019
52MP0001664_abnormal_digestion1.49454812
53MP0010386_abnormal_urinary_bladder1.49320839
54MP0005220_abnormal_exocrine_pancreas1.47679038
55MP0009780_abnormal_chondrocyte_physiolo1.46194326
56MP0002909_abnormal_adrenal_gland1.43253013
57MP0000678_abnormal_parathyroid_gland1.42858249
58MP0005379_endocrine/exocrine_gland_phen1.42529421
59MP0004924_abnormal_behavior1.42273766
60MP0005386_behavior/neurological_phenoty1.42273766
61MP0003868_abnormal_feces_composition1.41865489
62MP0001486_abnormal_startle_reflex1.41184357
63MP0002734_abnormal_mechanical_nocicepti1.41108585
64MP0001756_abnormal_urination1.40182991
65MP0005499_abnormal_olfactory_system1.39651783
66MP0005394_taste/olfaction_phenotype1.39651783
67MP0002118_abnormal_lipid_homeostasis1.39581789
68MP0005381_digestive/alimentary_phenotyp1.36695627
69MP0002234_abnormal_pharynx_morphology1.36690690
70MP0001873_stomach_inflammation1.35520746
71MP0002822_catalepsy1.35253333
72MP0002876_abnormal_thyroid_physiology1.34465599
73MP0002102_abnormal_ear_morphology1.34465305
74MP0004215_abnormal_myocardial_fiber1.33077198
75MP0000013_abnormal_adipose_tissue1.32231795
76MP0002078_abnormal_glucose_homeostasis1.30686421
77MP0003121_genomic_imprinting1.30590232
78MP0006035_abnormal_mitochondrial_morpho1.30584382
79MP0004142_abnormal_muscle_tone1.30536130
80MP0005310_abnormal_salivary_gland1.29758596
81MP0005083_abnormal_biliary_tract1.29169711
82MP0003186_abnormal_redox_activity1.29058393
83MP0001663_abnormal_digestive_system1.28978596
84MP0000609_abnormal_liver_physiology1.28773461
85MP0005423_abnormal_somatic_nervous1.28367977
86MP0001968_abnormal_touch/_nociception1.27895217
87MP0002557_abnormal_social/conspecific_i1.27561720
88MP0000778_abnormal_nervous_system1.26897087
89MP0006054_spinal_hemorrhage1.25336472
90MP0000538_abnormal_urinary_bladder1.25327064
91MP0005646_abnormal_pituitary_gland1.25088236
92MP0003300_gastrointestinal_ulcer1.21982968
93MP0001502_abnormal_circadian_rhythm1.21326017
94MP0005319_abnormal_enzyme/_coenzyme1.20183649
95MP0001984_abnormal_olfaction1.19765840
96MP0005187_abnormal_penis_morphology1.17588929
97MP0000613_abnormal_salivary_gland1.17197042
98MP0004811_abnormal_neuron_physiology1.16821709
99MP0003567_abnormal_fetal_cardiomyocyte1.11576787
100MP0000490_abnormal_crypts_of1.10523511
101MP0002733_abnormal_thermal_nociception1.09844935
102MP0002837_dystrophic_cardiac_calcinosis1.08800453
103MP0010155_abnormal_intestine_physiology1.08536698
104MP0005551_abnormal_eye_electrophysiolog1.07542945
105MP0005248_abnormal_Harderian_gland1.06596808
106MP0001970_abnormal_pain_threshold1.06575547
107MP0002736_abnormal_nociception_after1.05609994
108MP0008877_abnormal_DNA_methylation1.04871481
109MP0001501_abnormal_sleep_pattern1.04709558
110MP0006036_abnormal_mitochondrial_physio1.03254578
111MP0003656_abnormal_erythrocyte_physiolo1.03087937
112MP0002163_abnormal_gland_morphology1.02975378
113MP0000477_abnormal_intestine_morphology1.02717769
114MP0004782_abnormal_surfactant_physiolog1.02033349
115MP0002735_abnormal_chemical_nociception1.01371311
116MP0000631_abnormal_neuroendocrine_gland1.01211363
117MP0002067_abnormal_sensory_capabilities0.98538140
118MP0002160_abnormal_reproductive_system0.97731657
119MP0010352_gastrointestinal_tract_polyps0.96659288
120MP0008004_abnormal_stomach_pH0.96633272
121MP0002229_neurodegeneration0.95339454
122MP0004885_abnormal_endolymph0.93952161
123MP0003221_abnormal_cardiomyocyte_apopto0.93083683
124MP0002066_abnormal_motor_capabilities/c0.92062891
125MP0003633_abnormal_nervous_system0.91850291
126MP0008058_abnormal_DNA_repair0.90754942
127MP0005058_abnormal_lysosome_morphology0.89449804
128MP0008872_abnormal_physiological_respon0.88652760
129MP0005448_abnormal_energy_balance0.88038984
130MP0006072_abnormal_retinal_apoptosis0.87953064
131MP0003953_abnormal_hormone_level0.87390588
132MP0002882_abnormal_neuron_morphology0.87240434
133MP0001440_abnormal_grooming_behavior0.86973991
134MP0000681_abnormal_thyroid_gland0.86819674
135MP0003631_nervous_system_phenotype0.86552511
136MP0002638_abnormal_pupillary_reflex0.85806779
137MP0002090_abnormal_vision0.84624746
138MP0002184_abnormal_innervation0.84570934
139MP0005584_abnormal_enzyme/coenzyme_acti0.83639122
140MP0008260_abnormal_autophagy0.82865409
141MP0005253_abnormal_eye_physiology0.82578168
142MP0000358_abnormal_cell_content/0.82433392
143MP0000955_abnormal_spinal_cord0.82247936
144MP0008775_abnormal_heart_ventricle0.81530526
145MP0004133_heterotaxia0.79424936
146MP0002136_abnormal_kidney_physiology0.79109169
147MP0009642_abnormal_blood_homeostasis0.79094354
148MP0004085_abnormal_heartbeat0.77842012
149MP0004484_altered_response_of0.77101037
150MP0000003_abnormal_adipose_tissue0.75602971
151MP0002009_preneoplasia0.72694472
152MP0002069_abnormal_eating/drinking_beha0.71103029
153MP0002896_abnormal_bone_mineralization0.71082029
154MP0005167_abnormal_blood-brain_barrier0.70400643
155MP0002152_abnormal_brain_morphology0.69209868
156MP0000015_abnormal_ear_pigmentation0.69135428
157MP0005408_hypopigmentation0.66581599
158MP0001764_abnormal_homeostasis0.66202054
159MP0000230_abnormal_systemic_arterial0.66129430
160MP0001346_abnormal_lacrimal_gland0.65321761
161MP0003879_abnormal_hair_cell0.63498699
162MP0002277_abnormal_respiratory_mucosa0.62426106
163MP0005266_abnormal_metabolism0.62388048
164MP0005535_abnormal_body_temperature0.59699065
165MP0009384_cardiac_valve_regurgitation0.57197889
166MP0000598_abnormal_liver_morphology0.56759556
167MP0000537_abnormal_urethra_morphology0.55611984
168MP0003718_maternal_effect0.53725819
169MP0000470_abnormal_stomach_morphology0.53415213
170MP0002098_abnormal_vibrissa_morphology0.52712021
171MP0001881_abnormal_mammary_gland0.51684438
172MP0005334_abnormal_fat_pad0.49527071

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.82762644
2Hyperactive renin-angiotensin system (HP:0000841)4.23699665
3Gout (HP:0001997)4.17534348
4Ileus (HP:0002595)3.99093116
5Hyperglycinuria (HP:0003108)3.96538477
6Limb dystonia (HP:0002451)3.91693141
7Ketoacidosis (HP:0001993)3.84744703
8Abnormality of glutamine family amino acid metabolism (HP:0010902)3.76172677
9Hypoglycemic seizures (HP:0002173)3.75903759
10Conjugated hyperbilirubinemia (HP:0002908)3.70822060
11Hyperinsulinemic hypoglycemia (HP:0000825)3.70350078
12Symptomatic seizures (HP:0011145)3.57117370
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.36660234
14Acute necrotizing encephalopathy (HP:0006965)3.26020774
15Abnormality of purine metabolism (HP:0004352)3.24612048
16Generalized aminoaciduria (HP:0002909)3.23204412
17Abnormality of chloride homeostasis (HP:0011422)3.22977316
18Abnormal mitochondria in muscle tissue (HP:0008316)3.19566389
19Glycosuria (HP:0003076)3.19367546
20Abnormality of urine glucose concentration (HP:0011016)3.19367546
21Late onset (HP:0003584)3.10805742
22Progressive macrocephaly (HP:0004481)3.04614653
23Acute encephalopathy (HP:0006846)3.03436877
24Hydroxyprolinuria (HP:0003080)3.00253466
25Abnormality of proline metabolism (HP:0010907)3.00253466
26Abdominal distention (HP:0003270)2.99794247
27Abnormality of serine family amino acid metabolism (HP:0010894)2.98856659
28Abnormality of glycine metabolism (HP:0010895)2.98856659
29Right ventricular cardiomyopathy (HP:0011663)2.97371975
30Abnormal pancreas size (HP:0012094)2.96708532
31Hyperglycemia (HP:0003074)2.93341276
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92011295
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92011295
34Palpitations (HP:0001962)2.90026755
35Gait imbalance (HP:0002141)2.89542661
36Decreased circulating renin level (HP:0003351)2.84945889
37Ketosis (HP:0001946)2.83649937
38Medial flaring of the eyebrow (HP:0010747)2.82135172
39Abnormality of alanine metabolism (HP:0010916)2.79483427
40Hyperalaninemia (HP:0003348)2.79483427
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79483427
42Increased CSF lactate (HP:0002490)2.77082036
43Abnormality of renin-angiotensin system (HP:0000847)2.76443962
44Abnormality of fatty-acid metabolism (HP:0004359)2.76052431
45Fat malabsorption (HP:0002630)2.75055569
46Hypobetalipoproteinemia (HP:0003563)2.73665646
47Insulin-resistant diabetes mellitus (HP:0000831)2.73038888
48Acanthocytosis (HP:0001927)2.72588201
49Mitochondrial inheritance (HP:0001427)2.69312649
50Abnormal tarsal ossification (HP:0008369)2.66628455
51Cerebral edema (HP:0002181)2.61465369
52Hepatocellular necrosis (HP:0001404)2.60269835
53Hypokalemia (HP:0002900)2.60225229
54Increased purine levels (HP:0004368)2.60040119
55Hyperuricemia (HP:0002149)2.60040119
56Proximal tubulopathy (HP:0000114)2.59746715
57Hyperphosphaturia (HP:0003109)2.59703782
58Congenital primary aphakia (HP:0007707)2.57650566
59Polycythemia (HP:0001901)2.56861899
60Increased hepatocellular lipid droplets (HP:0006565)2.55462216
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54356494
62Focal motor seizures (HP:0011153)2.54093367
63Dicarboxylic aciduria (HP:0003215)2.53287533
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53287533
65Autoimmune thrombocytopenia (HP:0001973)2.53097518
66Polyphagia (HP:0002591)2.51448845
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.49709612
68Hyperaldosteronism (HP:0000859)2.49332911
69Nephrogenic diabetes insipidus (HP:0009806)2.48316771
70Hyperparathyroidism (HP:0000843)2.47503666
71Xanthomatosis (HP:0000991)2.46993984
72Hyperglycinemia (HP:0002154)2.46083925
73Lipid accumulation in hepatocytes (HP:0006561)2.45878992
74Urinary glycosaminoglycan excretion (HP:0003541)2.44352807
75Mucopolysacchariduria (HP:0008155)2.44352807
76Myokymia (HP:0002411)2.43488634
77Muscular hypotonia of the trunk (HP:0008936)2.42080317
78Malnutrition (HP:0004395)2.41730493
79Abnormal biliary tract morphology (HP:0012440)2.41294233
80Metabolic acidosis (HP:0001942)2.40786248
81Hypsarrhythmia (HP:0002521)2.38683315
82Intrahepatic cholestasis (HP:0001406)2.38280523
83Hyperammonemia (HP:0001987)2.38264180
84EEG with generalized epileptiform discharges (HP:0011198)2.35361823
85Hepatic necrosis (HP:0002605)2.34213049
86Epileptiform EEG discharges (HP:0011182)2.32219785
87Abnormality of monocarboxylic acid metabolism (HP:0010996)2.31854665
88Lactic acidosis (HP:0003128)2.29387903
89Cupped ribs (HP:0000887)2.29118612
90Increased serum pyruvate (HP:0003542)2.25299995
91Poor suck (HP:0002033)2.24392084
92Flat acetabular roof (HP:0003180)2.23952380
93Pheochromocytoma (HP:0002666)2.23812700
94Exocrine pancreatic insufficiency (HP:0001738)2.23767098
95Increased serum lactate (HP:0002151)2.22915801
96Lethargy (HP:0001254)2.22277344
97Metabolic alkalosis (HP:0200114)2.21558965
98Epileptic encephalopathy (HP:0200134)2.20367382
993-Methylglutaconic aciduria (HP:0003535)2.19955327
100Abnormality of endocrine pancreas physiology (HP:0012093)2.19166105
101Abnormality of the pancreatic islet cells (HP:0006476)2.19166105
102Febrile seizures (HP:0002373)2.18452603
103Goiter (HP:0000853)2.16977777
104Degeneration of the lateral corticospinal tracts (HP:0002314)2.16966304
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16966304
106Neuroendocrine neoplasm (HP:0100634)2.15946276
107Hypolipoproteinemia (HP:0010981)2.15717628
108Insulin resistance (HP:0000855)2.14957744
109Pancreatic fibrosis (HP:0100732)2.14698261
110Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14597181
111Abnormality of polysaccharide metabolism (HP:0011012)2.14597181
112Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14597181
113Type II lissencephaly (HP:0007260)2.13930093
114Increased intramyocellular lipid droplets (HP:0012240)2.11770853
115Abnormality of nucleobase metabolism (HP:0010932)2.10340758
116Drooling (HP:0002307)2.10206060
117Pancreatic cysts (HP:0001737)2.10017712
118Abnormality of potassium homeostasis (HP:0011042)2.09860111
119Abnormality of magnesium homeostasis (HP:0004921)2.08326278
120Hyperventilation (HP:0002883)2.07915745
121Alkalosis (HP:0001948)2.07868026
122Myopathic facies (HP:0002058)2.06765986
123Dehydration (HP:0001944)2.05289135
124Hypothermia (HP:0002045)2.05228977
125Abnormality of glycolysis (HP:0004366)2.04772459
126Hypotension (HP:0002615)2.04244344
127Generalized tonic-clonic seizures (HP:0002069)2.04051914
128Poikilocytosis (HP:0004447)2.01951203
129Increased muscle lipid content (HP:0009058)2.01534099
130Abnormality of the intrinsic pathway (HP:0010989)2.01109191
131Sensorimotor neuropathy (HP:0007141)2.00970541
132Irritability (HP:0000737)2.00837630
133Abnormal urine phosphate concentration (HP:0012599)1.99857735
134Dysostosis multiplex (HP:0000943)1.99476133
135Pancreatitis (HP:0001733)1.99134384
136Syncope (HP:0001279)1.98346824
137Vacuolated lymphocytes (HP:0001922)1.97890842
138Abnormality of macular pigmentation (HP:0008002)1.97782702
139Urinary urgency (HP:0000012)1.97614878
140Spastic tetraplegia (HP:0002510)1.97447813
141Renal cortical cysts (HP:0000803)1.97132927
142Focal seizures (HP:0007359)1.96772283
143Hyperbilirubinemia (HP:0002904)1.96425975
144Chronic bronchitis (HP:0004469)1.96092477
145Adrenal overactivity (HP:0002717)1.95739293
146Short tibia (HP:0005736)1.95698925
147Hypokalemic alkalosis (HP:0001949)1.95301000
148Abnormality of the corticospinal tract (HP:0002492)1.94834452
149Nephrolithiasis (HP:0000787)1.92591597
150Methylmalonic acidemia (HP:0002912)1.92492816
151Hyperphosphatemia (HP:0002905)1.92042133
152Amyotrophic lateral sclerosis (HP:0007354)1.90876062
153Cerebral hypomyelination (HP:0006808)1.89632998
154Absence seizures (HP:0002121)1.89399750
155Abnormal cartilage morphology (HP:0002763)1.89212726
156True hermaphroditism (HP:0010459)1.89179150
157Abnormality of vitamin B metabolism (HP:0004340)1.88565438
158Specific learning disability (HP:0001328)1.87614185
159Aplasia/hypoplasia of the uterus (HP:0008684)1.86094597
160Atrophy/Degeneration involving motor neurons (HP:0007373)1.85449967
161Genital tract atresia (HP:0001827)1.85425932
162CNS demyelination (HP:0007305)1.84485813
163Lissencephaly (HP:0001339)1.83247974
164Emotional lability (HP:0000712)1.82891942
165Villous atrophy (HP:0011473)1.82764284
166Abnormality of small intestinal villus morphology (HP:0011472)1.82764284
167Dialeptic seizures (HP:0011146)1.81697882
168Vaginal atresia (HP:0000148)1.81158167
169Atonic seizures (HP:0010819)1.80279285
170CNS hypomyelination (HP:0003429)1.79208323
171Degeneration of anterior horn cells (HP:0002398)1.78785686
172Abnormality of the anterior horn cell (HP:0006802)1.78785686
173Progressive microcephaly (HP:0000253)1.78662994
174Excessive salivation (HP:0003781)1.78609410
175Delayed myelination (HP:0012448)1.77209779
176Abnormality of midbrain morphology (HP:0002418)1.76484487
177Molar tooth sign on MRI (HP:0002419)1.76484487
178Abnormality of serum amino acid levels (HP:0003112)1.74355902
179Aplasia/Hypoplasia of the tibia (HP:0005772)1.74176851
180Morphological abnormality of the pyramidal tract (HP:0002062)1.73771300
181Status epilepticus (HP:0002133)1.73097385
182Inability to walk (HP:0002540)1.70979139
183Respiratory failure (HP:0002878)1.70749817
184Abnormality of the vitamin B12 metabolism (HP:0004341)1.70150574
185Methylmalonic aciduria (HP:0012120)1.68359090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.37228634
2INSRR3.59116387
3MAPK153.56667297
4MST43.19146311
5MST1R2.94119445
6EPHA22.84805105
7MAP3K42.69448570
8MARK12.67030590
9BCKDK2.56174748
10MAP2K22.54587118
11ARAF2.53896996
12MAP2K72.51026480
13LMTK22.50457165
14MAP3K22.46776248
15MAP4K22.26752788
16STK392.06888103
17SIK32.03501064
18TESK12.02809451
19EIF2AK31.99331423
20CSNK1G31.97085544
21EIF2AK11.96179784
22CSNK1G21.93212030
23NTRK11.89921083
24CASK1.84421445
25ERN11.82390171
26BMPR1B1.78909597
27TRIM281.77041410
28NTRK31.74466471
29EPHA41.73355122
30TAOK31.68363491
31PIM21.67513691
32CSNK1G11.65696234
33CSNK1A1L1.61920728
34PRKG21.59801385
35PASK1.56232127
36WNK41.51875655
37NME11.51618702
38OXSR11.47561727
39FER1.46380470
40SCYL21.45497019
41TNIK1.39468232
42PHKG11.38266689
43PHKG21.38266689
44CCNB11.37220088
45GRK11.35100516
46BCR1.33273694
47MET1.32943792
48MAP2K11.31006717
49RPS6KA41.29005369
50EPHB21.24297350
51IRAK31.23864917
52SRPK11.23696617
53PTK61.23584018
54BUB11.19900192
55MAP3K11.19435274
56MAPK131.18615356
57AKT31.16089420
58PRKCI1.12515559
59MINK11.11793197
60CDK191.10922717
61MAPKAPK31.10311238
62MAP3K31.10263821
63PLK21.07611433
64MAP2K41.05354412
65GRK61.03478044
66MAP3K111.02622110
67BRAF1.01256472
68NEK91.00038669
69NLK0.99816082
70PTK20.97796420
71FLT30.97444537
72LIMK10.96244104
73DYRK20.95660845
74MAP3K120.95473094
75PIK3CA0.94419650
76DAPK20.93536053
77HIPK20.91551155
78PRKCG0.90034912
79CAMKK20.87625692
80SIK10.87086223
81EPHA30.86815134
82KSR20.86207376
83CAMK2A0.83176661
84PAK60.82683367
85PAK30.82676954
86EPHB10.81924680
87IRAK10.81281474
88PBK0.80898659
89CAMK2B0.80692489
90TRIB30.79826488
91MAP2K60.78537619
92ERBB30.75375790
93KSR10.75197900
94PRKD30.73245288
95MATK0.72021409
96ACVR1B0.71961996
97ABL20.70474743
98STK160.69208671
99LATS20.68923620
100WNK30.67379110
101CDK140.66533231
102MYLK0.64716901
103PRKAA10.63358345
104BRSK20.62706060
105ZAK0.61661268
106CAMK2D0.60799175
107TAOK10.59617420
108DYRK30.58110752
109PLK10.57689296
110ADRBK20.57070355
111PIK3CG0.56720302
112RPS6KA50.56450911
113RIPK10.56132652
114TIE10.55972737
115STK240.55948058
116TSSK60.55314342
117TBK10.55179741
118PDK30.55152128
119PDK40.55152128
120NEK10.55074947
121NTRK20.54451083
122DAPK10.52722376
123PLK30.52162248
124CHUK0.51500987
125ERBB40.50112072
126MAPKAPK50.49237586
127CDK50.49107530
128NUAK10.48799670
129CSNK1E0.48123329
130DYRK1B0.47608999
131CAMK2G0.46729625
132ERBB20.46435550
133PAK40.46028083
134NME20.45506146
135DYRK1A0.45253336
136ZAP700.45198685
137CDK180.44193683
138BMPR20.42883401
139MAP3K100.42346796
140PRKAA20.41366275
141TGFBR20.40135088
142MAP3K50.39035997
143TLK10.38730642
144CDK80.37622491
145STK38L0.37376466
146CDK150.36924647
147PRKCE0.36639928
148PINK10.35893866
149MAPKAPK20.35539639
150MAP2K30.35496407
151CDK11A0.35099009
152JAK30.34902718
153LRRK20.34618290
154PDK20.34456132
155PRKACB0.33833260
156CSNK2A10.33386887
157PRKACA0.32423736
158PDPK10.31452713
159MAPK110.30631221
160CSNK1A10.29982734

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.89275716
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.49213477
3Fat digestion and absorption_Homo sapiens_hsa049753.30887527
4Nicotine addiction_Homo sapiens_hsa050332.75947704
5Folate biosynthesis_Homo sapiens_hsa007902.74021899
6Mineral absorption_Homo sapiens_hsa049782.62206288
7Vitamin digestion and absorption_Homo sapiens_hsa049772.34936201
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33354719
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27856737
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23591577
11Synaptic vesicle cycle_Homo sapiens_hsa047212.21720684
12Caffeine metabolism_Homo sapiens_hsa002322.11586191
13Renin-angiotensin system_Homo sapiens_hsa046142.10421135
14Galactose metabolism_Homo sapiens_hsa000522.02169690
15Starch and sucrose metabolism_Homo sapiens_hsa005002.01320039
16Protein export_Homo sapiens_hsa030601.96670212
17Histidine metabolism_Homo sapiens_hsa003401.88545150
18Fatty acid degradation_Homo sapiens_hsa000711.87416000
19Tryptophan metabolism_Homo sapiens_hsa003801.84956713
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84410185
21Butanoate metabolism_Homo sapiens_hsa006501.82147444
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80555113
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74967598
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.69531156
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67941216
26GABAergic synapse_Homo sapiens_hsa047271.59115279
27Glutathione metabolism_Homo sapiens_hsa004801.56063432
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.53025895
29Selenocompound metabolism_Homo sapiens_hsa004501.47740566
30Cardiac muscle contraction_Homo sapiens_hsa042601.44554114
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41979116
32Bile secretion_Homo sapiens_hsa049761.41178317
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38735197
34Fructose and mannose metabolism_Homo sapiens_hsa000511.37382582
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36226197
36Basal transcription factors_Homo sapiens_hsa030221.33456817
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27999268
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24951557
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20752689
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20712501
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17854174
42Propanoate metabolism_Homo sapiens_hsa006401.16452719
43Sulfur relay system_Homo sapiens_hsa041221.15843354
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13463649
45PPAR signaling pathway_Homo sapiens_hsa033201.11548150
46Regulation of autophagy_Homo sapiens_hsa041401.10744293
47Dopaminergic synapse_Homo sapiens_hsa047281.08742150
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08540276
49Peroxisome_Homo sapiens_hsa041461.08506294
50Morphine addiction_Homo sapiens_hsa050321.07651357
51Vibrio cholerae infection_Homo sapiens_hsa051101.06973995
52beta-Alanine metabolism_Homo sapiens_hsa004101.04761533
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.04563556
54Chemical carcinogenesis_Homo sapiens_hsa052041.03499550
55Amphetamine addiction_Homo sapiens_hsa050311.00192153
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99339802
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98054635
58Protein digestion and absorption_Homo sapiens_hsa049740.97360294
59Cocaine addiction_Homo sapiens_hsa050300.93660706
60Pyruvate metabolism_Homo sapiens_hsa006200.93502778
61Arginine and proline metabolism_Homo sapiens_hsa003300.93165309
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92631894
63Glycerolipid metabolism_Homo sapiens_hsa005610.91448569
64Phototransduction_Homo sapiens_hsa047440.89182671
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89091781
66RNA polymerase_Homo sapiens_hsa030200.88659665
67Steroid biosynthesis_Homo sapiens_hsa001000.88603429
68Taste transduction_Homo sapiens_hsa047420.88579233
69Fatty acid metabolism_Homo sapiens_hsa012120.83937845
70Glutamatergic synapse_Homo sapiens_hsa047240.82411814
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82177610
72Pancreatic secretion_Homo sapiens_hsa049720.81856826
73ABC transporters_Homo sapiens_hsa020100.81436616
74N-Glycan biosynthesis_Homo sapiens_hsa005100.80638070
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.80182517
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79925219
77Phenylalanine metabolism_Homo sapiens_hsa003600.79202143
78Carbon metabolism_Homo sapiens_hsa012000.79168909
79Pyrimidine metabolism_Homo sapiens_hsa002400.78672472
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78478443
81Ether lipid metabolism_Homo sapiens_hsa005650.77725544
82Pentose phosphate pathway_Homo sapiens_hsa000300.76756120
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74461527
84Purine metabolism_Homo sapiens_hsa002300.74342973
85Circadian entrainment_Homo sapiens_hsa047130.73396372
86Thyroid hormone synthesis_Homo sapiens_hsa049180.73115148
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.71861476
88Retinol metabolism_Homo sapiens_hsa008300.71753375
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71680180
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70619600
91Oxidative phosphorylation_Homo sapiens_hsa001900.70065850
92Insulin secretion_Homo sapiens_hsa049110.69822188
93Linoleic acid metabolism_Homo sapiens_hsa005910.68925297
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67936519
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65996765
96Serotonergic synapse_Homo sapiens_hsa047260.65996499
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64504953
98RNA degradation_Homo sapiens_hsa030180.64118704
99Biosynthesis of amino acids_Homo sapiens_hsa012300.61372661
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58779647
101Arginine biosynthesis_Homo sapiens_hsa002200.57259179
102* Metabolic pathways_Homo sapiens_hsa011000.57107822
103Arachidonic acid metabolism_Homo sapiens_hsa005900.56247796
104Collecting duct acid secretion_Homo sapiens_hsa049660.54888291
105Nitrogen metabolism_Homo sapiens_hsa009100.54475535
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53517905
107Ribosome_Homo sapiens_hsa030100.53215626
108Lysosome_Homo sapiens_hsa041420.53004169
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52567162
110Parkinsons disease_Homo sapiens_hsa050120.51770389
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51301458
112Sphingolipid metabolism_Homo sapiens_hsa006000.50856870
113Insulin resistance_Homo sapiens_hsa049310.49671231
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49613620
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48962797
116Fanconi anemia pathway_Homo sapiens_hsa034600.48854619
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.47806712
118Circadian rhythm_Homo sapiens_hsa047100.45792080
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.44280254
120Tyrosine metabolism_Homo sapiens_hsa003500.43907312
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43356060
122Other glycan degradation_Homo sapiens_hsa005110.42690646
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41456450
124Alzheimers disease_Homo sapiens_hsa050100.41227413
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.38800704
126Thyroid cancer_Homo sapiens_hsa052160.36637356
127Prolactin signaling pathway_Homo sapiens_hsa049170.30143750
128Fatty acid elongation_Homo sapiens_hsa000620.29637017
129Proteasome_Homo sapiens_hsa030500.29394203
130Tight junction_Homo sapiens_hsa045300.28491933
131Type II diabetes mellitus_Homo sapiens_hsa049300.26667538
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26466546
133Insulin signaling pathway_Homo sapiens_hsa049100.23494803
134Hepatitis C_Homo sapiens_hsa051600.23244143
135Huntingtons disease_Homo sapiens_hsa050160.18533649
136Vitamin B6 metabolism_Homo sapiens_hsa007500.18099978

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