REXO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.94357139
2nucleobase biosynthetic process (GO:0046112)4.55762960
3DNA unwinding involved in DNA replication (GO:0006268)4.53507501
4purine nucleobase biosynthetic process (GO:0009113)4.39573500
5formation of translation preinitiation complex (GO:0001731)4.37130734
6maturation of SSU-rRNA (GO:0030490)4.36698055
7DNA strand elongation involved in DNA replication (GO:0006271)4.28965670
8DNA replication initiation (GO:0006270)4.25089872
9regulation of translational fidelity (GO:0006450)4.21760734
10DNA replication checkpoint (GO:0000076)4.12761101
11ribosomal small subunit assembly (GO:0000028)4.11431559
12mitotic nuclear envelope disassembly (GO:0007077)4.02869429
13ribosome assembly (GO:0042255)4.02103620
14ribosome biogenesis (GO:0042254)4.00504539
15DNA strand elongation (GO:0022616)3.99398628
16folic acid-containing compound biosynthetic process (GO:0009396)3.97977396
17protein localization to kinetochore (GO:0034501)3.95145841
18peptidyl-arginine omega-N-methylation (GO:0035247)3.93035350
19IMP biosynthetic process (GO:0006188)3.87506867
20mitotic metaphase plate congression (GO:0007080)3.82353534
21telomere maintenance via semi-conservative replication (GO:0032201)3.79918563
22folic acid metabolic process (GO:0046655)3.77224154
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.76566033
24proline biosynthetic process (GO:0006561)3.75962159
25membrane disassembly (GO:0030397)3.73659283
26nuclear envelope disassembly (GO:0051081)3.73659283
27viral life cycle (GO:0019058)3.73429134
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.72732820
29COPI coating of Golgi vesicle (GO:0048205)3.65625483
30Golgi transport vesicle coating (GO:0048200)3.65625483
31protein targeting to ER (GO:0045047)3.65463643
32cotranslational protein targeting to membrane (GO:0006613)3.61256209
33regulation of spindle organization (GO:0090224)3.61048074
34regulation of translational termination (GO:0006449)3.58925926
35nuclear pore organization (GO:0006999)3.54846705
36cellular protein complex disassembly (GO:0043624)3.53662153
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53603708
38nucleobase-containing small molecule interconversion (GO:0015949)3.50967254
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.50334232
40protein localization to endoplasmic reticulum (GO:0070972)3.41874356
41ribonucleoprotein complex biogenesis (GO:0022613)3.40694048
42protein complex disassembly (GO:0043241)3.40566206
43histone arginine methylation (GO:0034969)3.38453756
44telomere maintenance via recombination (GO:0000722)3.37089219
45IMP metabolic process (GO:0046040)3.34417908
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33595653
47mitotic sister chromatid segregation (GO:0000070)3.31839057
48heterochromatin organization (GO:0070828)3.31299751
49histone-serine phosphorylation (GO:0035404)3.28808040
50protein maturation by protein folding (GO:0022417)3.28199130
51metaphase plate congression (GO:0051310)3.27572102
52mitotic chromosome condensation (GO:0007076)3.27260016
53negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.26912303
54DNA deamination (GO:0045006)3.25813416
55regulation of mitotic spindle organization (GO:0060236)3.24313676
56protein localization to chromosome, centromeric region (GO:0071459)3.23363022
57macromolecular complex disassembly (GO:0032984)3.21470161
58mitotic recombination (GO:0006312)3.21046902
59regulation of translation in response to stress (GO:0043555)3.18996677
60protein complex localization (GO:0031503)3.18829011
61rRNA processing (GO:0006364)3.18553004
62peptidyl-arginine methylation (GO:0018216)3.18142118
63peptidyl-arginine N-methylation (GO:0035246)3.18142118
64pentose-phosphate shunt (GO:0006098)3.17808978
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17763993
66establishment of integrated proviral latency (GO:0075713)3.16121481
67spliceosomal snRNP assembly (GO:0000387)3.15259995
68rRNA transcription (GO:0009303)3.12818531
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12663043
70CENP-A containing nucleosome assembly (GO:0034080)3.12497381
71spliceosomal tri-snRNP complex assembly (GO:0000244)3.12126078
72mitotic G1 DNA damage checkpoint (GO:0031571)3.12007957
73rRNA metabolic process (GO:0016072)3.09597410
74chromatin remodeling at centromere (GO:0031055)3.08707110
75ribosomal large subunit biogenesis (GO:0042273)3.08090580
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05293328
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04525807
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04272065
79nuclear pore complex assembly (GO:0051292)3.03820638
80DNA duplex unwinding (GO:0032508)3.03727325
81negative regulation of RNA splicing (GO:0033119)3.02521985
82DNA geometric change (GO:0032392)3.00969469
83translational initiation (GO:0006413)3.00670647
843-UTR-mediated mRNA stabilization (GO:0070935)3.00110619
85telomere maintenance via telomere lengthening (GO:0010833)3.00052539
86establishment of chromosome localization (GO:0051303)2.98336978
87antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.95457853
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95457853
89DNA replication-independent nucleosome organization (GO:0034724)2.94678325
90DNA replication-independent nucleosome assembly (GO:0006336)2.94678325
91pseudouridine synthesis (GO:0001522)2.94209916
92transcription from mitochondrial promoter (GO:0006390)2.92379404
93sister chromatid segregation (GO:0000819)2.92273534
94translational termination (GO:0006415)2.90666388
95G1/S transition of mitotic cell cycle (GO:0000082)2.90202621
96cell cycle G1/S phase transition (GO:0044843)2.90202621
97protein-DNA complex disassembly (GO:0032986)2.88934776
98nucleosome disassembly (GO:0006337)2.88934776
99L-serine metabolic process (GO:0006563)2.88461433
100viral transcription (GO:0019083)2.88335067
101negative regulation of mRNA processing (GO:0050686)2.88012886
102DNA replication-dependent nucleosome organization (GO:0034723)2.87951207
103DNA replication-dependent nucleosome assembly (GO:0006335)2.87951207
104kinetochore organization (GO:0051383)2.87331721
105spliceosomal complex assembly (GO:0000245)2.87101933
106nuclear envelope organization (GO:0006998)2.86223691
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.85313286
108NADPH regeneration (GO:0006740)2.85072441
109positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.84807292
110pentose metabolic process (GO:0019321)2.81792795
111mRNA stabilization (GO:0048255)2.81686896
112RNA stabilization (GO:0043489)2.81686896
113chromosome condensation (GO:0030261)2.81327790
114translational elongation (GO:0006414)2.80938277
115mRNA splicing, via spliceosome (GO:0000398)2.80265289
116RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.80265289
117cellular protein complex localization (GO:0034629)2.80138630
118protein targeting to membrane (GO:0006612)2.79996620
119protein retention in ER lumen (GO:0006621)2.79984172
120apoptotic process involved in morphogenesis (GO:0060561)2.79569152
121deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79449962
122mitochondrial fusion (GO:0008053)2.79279439
123antigen processing and presentation of endogenous antigen (GO:0019883)2.78672306
124RNA splicing, via transesterification reactions (GO:0000375)2.77794844
125mitotic nuclear envelope reassembly (GO:0007084)2.77698303
126nuclear envelope reassembly (GO:0031468)2.77698303
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77476229
128negative regulation of ligase activity (GO:0051352)2.77476229
129establishment of viral latency (GO:0019043)2.77460595
130translation (GO:0006412)2.77320685
131negative regulation of cell size (GO:0045792)2.75882511
132negative regulation of mRNA metabolic process (GO:1903312)2.75837218
133positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.75575851
134cellular component biogenesis (GO:0044085)2.75258968
135regulation of mitochondrial translation (GO:0070129)2.73874211
136protein export from nucleus (GO:0006611)2.70298813
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.69340937
138postreplication repair (GO:0006301)2.68704348
139negative regulation of chromosome segregation (GO:0051985)2.68541473
140negative regulation of histone methylation (GO:0031061)2.67834686
141glucose catabolic process (GO:0006007)2.67178262
142nuclear-transcribed mRNA catabolic process (GO:0000956)2.66956100
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.66409969
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.66409969
145negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.66409969
146negative regulation of sister chromatid segregation (GO:0033046)2.66409969
147ncRNA 3-end processing (GO:0043628)2.64956758
148retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64923822
149mitotic spindle assembly checkpoint (GO:0007094)2.64715205
150transcription-coupled nucleotide-excision repair (GO:0006283)2.64596071
151spindle assembly checkpoint (GO:0071173)2.64105508
152nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.64039905
153transcription elongation from RNA polymerase I promoter (GO:0006362)2.62402373
154regulation of centrosome cycle (GO:0046605)2.62386974
155regulation of chromosome segregation (GO:0051983)2.61965176
156spindle checkpoint (GO:0031577)2.61204761
157mRNA catabolic process (GO:0006402)2.61022135
158positive regulation of chromosome segregation (GO:0051984)2.59080665
1597-methylguanosine mRNA capping (GO:0006370)2.59017367
160viral mRNA export from host cell nucleus (GO:0046784)2.58590166
161regulation of RNA export from nucleus (GO:0046831)2.57478965
162maternal placenta development (GO:0001893)2.57101453
163mitochondrial DNA metabolic process (GO:0032042)2.55626905
164intracellular estrogen receptor signaling pathway (GO:0030520)2.54498867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.82367898
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.01999987
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98099016
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.72434019
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19743846
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.85788131
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84340960
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83386971
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.78056027
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68198899
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67248186
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66802552
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.64639243
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.64042450
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62108699
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55837768
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46962208
18MYC_22102868_ChIP-Seq_BL_Human2.42813123
19* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29079365
20XRN2_22483619_ChIP-Seq_HELA_Human2.28437371
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26694718
22VDR_23849224_ChIP-Seq_CD4+_Human2.22202752
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03633205
24ZNF263_19887448_ChIP-Seq_K562_Human2.02971264
25CIITA_25753668_ChIP-Seq_RAJI_Human2.00582133
26* FOXP3_21729870_ChIP-Seq_TREG_Human1.96275905
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94618115
28DCP1A_22483619_ChIP-Seq_HELA_Human1.92259911
29* GABP_19822575_ChIP-Seq_HepG2_Human1.91246593
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.89709414
31AR_21909140_ChIP-Seq_LNCAP_Human1.88797625
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81703324
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80052914
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.78941784
35LXR_22292898_ChIP-Seq_THP-1_Human1.78717173
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77942077
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77911328
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73712359
39* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72464772
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70662153
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.69463806
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67672886
43KDM5A_27292631_Chip-Seq_BREAST_Human1.66742747
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66704500
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61520212
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59751974
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58369866
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58003169
49* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57849676
50TTF2_22483619_ChIP-Seq_HELA_Human1.57543520
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54721756
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54555680
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54180194
54ELK1_19687146_ChIP-ChIP_HELA_Human1.52801453
55RACK7_27058665_Chip-Seq_MCF-7_Human1.52185841
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51875720
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51340278
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51274781
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49892018
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49194363
61VDR_21846776_ChIP-Seq_THP-1_Human1.48962182
62* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48440479
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.47721224
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.44986675
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44860481
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41942497
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.39278866
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.38885728
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.36233695
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35511630
71TFEB_21752829_ChIP-Seq_HELA_Human1.34228527
72* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33761470
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33039762
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28083121
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.26765795
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25586140
77SPI1_23547873_ChIP-Seq_NB4_Human1.25310916
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25144792
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23925721
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23637265
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23287325
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22914795
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20588767
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19061467
85KDM2B_26808549_Chip-Seq_DND41_Human1.19056912
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18652821
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18601794
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17545166
89P68_20966046_ChIP-Seq_HELA_Human1.16923369
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16547973
91TCF7_22412390_ChIP-Seq_EML_Mouse1.15490713
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15248658
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15080823
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13494583
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13489266
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13472605
97GATA1_22025678_ChIP-Seq_K562_Human1.13378221
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12666641
99CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11034963
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10635153
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09814086
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09638846
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08516875
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07858580
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06441963
106* ATF3_27146783_Chip-Seq_COLON_Human1.05456917
107NCOR1_26117541_ChIP-Seq_K562_Human1.04949249
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04392453
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03820814
110MAF_26560356_Chip-Seq_TH1_Human1.03412919
111MAF_26560356_Chip-Seq_TH2_Human1.03369211
112* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01779287
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.01327935
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.99999966
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99804150
116FOXP1_21924763_ChIP-Seq_HESCs_Human0.99674363
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99497081
118MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97652268
119MYB_26560356_Chip-Seq_TH1_Human0.96962437
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96371129
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95105651
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93455798
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92263377
124MYB_26560356_Chip-Seq_TH2_Human0.92146553
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91371683
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91260547
127UTX_26944678_Chip-Seq_JUKART_Human0.88968629
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88634647
129* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88607752
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87479486
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85175009
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84312613
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83789987
134RUNX1_22412390_ChIP-Seq_EML_Mouse0.83419972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.42326144
2MP0003111_abnormal_nucleus_morphology4.25048374
3MP0010094_abnormal_chromosome_stability3.99688641
4MP0004957_abnormal_blastocyst_morpholog3.84928270
5MP0003077_abnormal_cell_cycle3.68304318
6MP0008057_abnormal_DNA_replication3.38066878
7MP0003123_paternal_imprinting3.27667925
8MP0005451_abnormal_body_composition3.18927811
9MP0002396_abnormal_hematopoietic_system3.11715304
10MP0008058_abnormal_DNA_repair2.98681286
11MP0002877_abnormal_melanocyte_morpholog2.96007176
12MP0004185_abnormal_adipocyte_glucose2.63626172
13MP0008007_abnormal_cellular_replicative2.59349380
14MP0001730_embryonic_growth_arrest2.36118639
15MP0001835_abnormal_antigen_presentation2.35821503
16MP0004233_abnormal_muscle_weight2.33482914
17MP0010307_abnormal_tumor_latency2.31594984
18MP0000350_abnormal_cell_proliferation2.20457095
19MP0000678_abnormal_parathyroid_gland2.10182224
20MP0010030_abnormal_orbit_morphology2.04654458
21MP0004808_abnormal_hematopoietic_stem2.03839892
22MP0008260_abnormal_autophagy1.98625171
23MP0010352_gastrointestinal_tract_polyps1.97975400
24MP0001849_ear_inflammation1.97883015
25MP0010234_abnormal_vibrissa_follicle1.97287763
26MP0003763_abnormal_thymus_physiology1.96875002
27MP0009333_abnormal_splenocyte_physiolog1.94743755
28MP0000685_abnormal_immune_system1.92387373
29MP0001545_abnormal_hematopoietic_system1.91980920
30MP0005397_hematopoietic_system_phenotyp1.91980920
31MP0002398_abnormal_bone_marrow1.91241880
32MP0005501_abnormal_skin_physiology1.84781836
33MP0000537_abnormal_urethra_morphology1.81742083
34MP0003786_premature_aging1.78177527
35MP0000689_abnormal_spleen_morphology1.75634198
36MP0002796_impaired_skin_barrier1.74159236
37MP0000490_abnormal_crypts_of1.73872974
38MP0002722_abnormal_immune_system1.72724468
39MP0009379_abnormal_foot_pigmentation1.72169289
40MP0001800_abnormal_humoral_immune1.66717442
41MP0000703_abnormal_thymus_morphology1.65599583
42MP0005076_abnormal_cell_differentiation1.64859239
43MP0008877_abnormal_DNA_methylation1.63460541
44MP0008932_abnormal_embryonic_tissue1.62280318
45MP0005623_abnormal_meninges_morphology1.59214159
46MP0002080_prenatal_lethality1.58413048
47MP0001697_abnormal_embryo_size1.56368851
48MP0002452_abnormal_antigen_presenting1.55321082
49MP0005380_embryogenesis_phenotype1.54920640
50MP0001672_abnormal_embryogenesis/_devel1.54920640
51MP0003303_peritoneal_inflammation1.54115707
52MP0002019_abnormal_tumor_incidence1.53037988
53MP0001348_abnormal_lacrimal_gland1.51957075
54MP0001853_heart_inflammation1.51292990
55MP0003984_embryonic_growth_retardation1.48635018
56MP0005671_abnormal_response_to1.47795175
57MP0003453_abnormal_keratinocyte_physiol1.47721496
58MP0004858_abnormal_nervous_system1.46039384
59MP0002429_abnormal_blood_cell1.45600135
60MP0000716_abnormal_immune_system1.44689161
61MP0001819_abnormal_immune_cell1.44602639
62MP0002420_abnormal_adaptive_immunity1.44544380
63MP0002088_abnormal_embryonic_growth/wei1.43387299
64MP0000733_abnormal_muscle_development1.41653197
65MP0002723_abnormal_immune_serum1.39291499
66MP0000313_abnormal_cell_death1.37734918
67MP0002249_abnormal_larynx_morphology1.35782006
68MP0002086_abnormal_extraembryonic_tissu1.33865648
69MP0001661_extended_life_span1.29628455
70MP0009840_abnormal_foam_cell1.28966165
71MP0003436_decreased_susceptibility_to1.27578658
72MP0003315_abnormal_perineum_morphology1.27399717
73MP0009053_abnormal_anal_canal1.25831534
74MP0000858_altered_metastatic_potential1.25365134
75MP0006035_abnormal_mitochondrial_morpho1.24305168
76MP0005025_abnormal_response_to1.22838435
77MP0005000_abnormal_immune_tolerance1.22553876
78MP0005257_abnormal_intraocular_pressure1.22532509
79MP0003806_abnormal_nucleotide_metabolis1.20674917
80MP0005387_immune_system_phenotype1.19554634
81MP0001790_abnormal_immune_system1.19554634
82MP0001346_abnormal_lacrimal_gland1.18766786
83MP0009785_altered_susceptibility_to1.18404250
84MP0005666_abnormal_adipose_tissue1.17510893
85MP0006054_spinal_hemorrhage1.17502333
86MP0003566_abnormal_cell_adhesion1.17449703
87MP0005464_abnormal_platelet_physiology1.16788531
88MP0009278_abnormal_bone_marrow1.14857032
89MP0000747_muscle_weakness1.12940770
90MP0000759_abnormal_skeletal_muscle1.10960835
91MP0002089_abnormal_postnatal_growth/wei1.09879847
92MP0002419_abnormal_innate_immunity1.09413000
93MP0005621_abnormal_cell_physiology1.08429796
94MP0002085_abnormal_embryonic_tissue1.05439134
95MP0002405_respiratory_system_inflammati1.04578970
96MP0003941_abnormal_skin_development1.04570876
97MP0005384_cellular_phenotype1.02563829
98MP0004197_abnormal_fetal_growth/weight/1.02530079
99MP0010155_abnormal_intestine_physiology1.01142904
100MP0001873_stomach_inflammation0.99166017
101MP0000003_abnormal_adipose_tissue0.98700888
102MP0002084_abnormal_developmental_patter0.98492417
103MP0005375_adipose_tissue_phenotype0.97064906
104MP0000358_abnormal_cell_content/0.96110437
105MP0004087_abnormal_muscle_fiber0.90448598
106MP0003718_maternal_effect0.89738515
107MP0010630_abnormal_cardiac_muscle0.89567595
108MP0003121_genomic_imprinting0.88940846
109MP0001845_abnormal_inflammatory_respons0.87888226
110MP0002697_abnormal_eye_size0.86506280
111MP0002060_abnormal_skin_morphology0.86431307
112MP0003656_abnormal_erythrocyte_physiolo0.86261350
113MP0000681_abnormal_thyroid_gland0.85615383
114MP0002092_abnormal_eye_morphology0.85000004
115MP0005330_cardiomyopathy0.84852662
116MP0002132_abnormal_respiratory_system0.84184266
117MP0000750_abnormal_muscle_regeneration0.82797491
118MP0002148_abnormal_hypersensitivity_rea0.82207043
119MP0001216_abnormal_epidermal_layer0.81581358
120MP0000762_abnormal_tongue_morphology0.81248312
121MP0003191_abnormal_cellular_cholesterol0.81235430
122MP0000751_myopathy0.80896698
123MP0001764_abnormal_homeostasis0.80738699
124MP0004947_skin_inflammation0.80493166
125MP0002269_muscular_atrophy0.79191264
126MP0003385_abnormal_body_wall0.78599334
127MP0003705_abnormal_hypodermis_morpholog0.77449326
128MP0003186_abnormal_redox_activity0.76964196
129MP0003221_abnormal_cardiomyocyte_apopto0.76575829
130MP0005023_abnormal_wound_healing0.74701345
131MP0000598_abnormal_liver_morphology0.74541421
132MP0008438_abnormal_cutaneous_collagen0.74413604
133MP0001727_abnormal_embryo_implantation0.72808414
134MP0001915_intracranial_hemorrhage0.71539195
135MP0002234_abnormal_pharynx_morphology0.71469007
136MP0002166_altered_tumor_susceptibility0.70635185
137MP0003942_abnormal_urinary_system0.69734842
138MP0003172_abnormal_lysosome_physiology0.69474522
139MP0002254_reproductive_system_inflammat0.68868666
140MP0003567_abnormal_fetal_cardiomyocyte0.68743320
141MP0002006_tumorigenesis0.68678686
142MP0005266_abnormal_metabolism0.67342783
143MP0006036_abnormal_mitochondrial_physio0.66877754
144MP0008469_abnormal_protein_level0.65012631
145MP0005058_abnormal_lysosome_morphology0.64955414
146MP0009672_abnormal_birth_weight0.64422677
147MP0000465_gastrointestinal_hemorrhage0.63616510
148MP0004510_myositis0.63141976
149MP0009697_abnormal_copulation0.62640830
150MP0003448_altered_tumor_morphology0.59751491
151MP0008770_decreased_survivor_rate0.59207312
152MP0001145_abnormal_male_reproductive0.57359467

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.42207004
2Thrombocytosis (HP:0001894)3.72687594
3Ragged-red muscle fibers (HP:0003200)3.49013649
4Degeneration of anterior horn cells (HP:0002398)3.47235787
5Abnormality of the anterior horn cell (HP:0006802)3.47235787
6Abnormality of cells of the erythroid lineage (HP:0012130)3.40855729
7Agnosia (HP:0010524)3.38082273
8Achilles tendon contracture (HP:0001771)3.34690276
9Abnormal number of erythroid precursors (HP:0012131)3.26147977
10Hyperacusis (HP:0010780)3.21640919
11IgM deficiency (HP:0002850)3.06821251
12Ependymoma (HP:0002888)3.02854826
13Rough bone trabeculation (HP:0100670)3.00258950
14Oral leukoplakia (HP:0002745)2.92902931
15Abnormality of the Achilles tendon (HP:0005109)2.88707644
16Aplasia/Hypoplasia of the sacrum (HP:0008517)2.87535111
17Aplastic anemia (HP:0001915)2.87423663
18Pustule (HP:0200039)2.82746900
19Trismus (HP:0000211)2.81932740
20Cerebral hypomyelination (HP:0006808)2.80519303
21Reticulocytopenia (HP:0001896)2.80170035
22Colon cancer (HP:0003003)2.78514744
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.75540166
24Carpal bone hypoplasia (HP:0001498)2.65665286
25Abnormal gallbladder physiology (HP:0012438)2.64530252
26Cholecystitis (HP:0001082)2.64530252
27Atrophy/Degeneration involving motor neurons (HP:0007373)2.63986225
28Progressive external ophthalmoplegia (HP:0000590)2.63471373
29Ulnar bowing (HP:0003031)2.62090045
30Recurrent viral infections (HP:0004429)2.60467359
31Breast hypoplasia (HP:0003187)2.59923462
32Myopathic facies (HP:0002058)2.48690501
33Myelodysplasia (HP:0002863)2.46459941
34Basal cell carcinoma (HP:0002671)2.45476505
35Cellular immunodeficiency (HP:0005374)2.45147142
36Distal lower limb amyotrophy (HP:0008944)2.44296875
37Broad distal phalanx of finger (HP:0009836)2.43761787
38Microretrognathia (HP:0000308)2.41743308
39Abnormality of chromosome stability (HP:0003220)2.38668517
40Selective tooth agenesis (HP:0001592)2.37971869
41Truncus arteriosus (HP:0001660)2.37808747
42Spinal muscular atrophy (HP:0007269)2.36101532
43Entropion (HP:0000621)2.33250475
44Lymphoma (HP:0002665)2.29151083
45Patellar aplasia (HP:0006443)2.29012557
46Amaurosis fugax (HP:0100576)2.28515050
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25880035
48Prominent nose (HP:0000448)2.25134673
49Abnormality of T cells (HP:0002843)2.23834094
50Abnormality of pyrimidine metabolism (HP:0004353)2.23052765
51Bone marrow hypocellularity (HP:0005528)2.22906002
52Calcaneovalgus deformity (HP:0001848)2.22893292
53Abnormality of the umbilical cord (HP:0010881)2.22637238
54Aplasia/Hypoplasia of the patella (HP:0006498)2.22385232
55Vertebral compression fractures (HP:0002953)2.20755205
56Impulsivity (HP:0100710)2.20382049
57Insomnia (HP:0100785)2.20301097
58Increased connective tissue (HP:0009025)2.20182183
59Multiple enchondromatosis (HP:0005701)2.19344246
60Short nail (HP:0001799)2.19219605
61T lymphocytopenia (HP:0005403)2.18793894
62Long palpebral fissure (HP:0000637)2.17958373
63Neoplasm of the pancreas (HP:0002894)2.16306235
64Poikiloderma (HP:0001029)2.15591204
65Personality changes (HP:0000751)2.15322116
66Pallor (HP:0000980)2.14372287
67Abnormality of the preputium (HP:0100587)2.13231899
68Mediastinal lymphadenopathy (HP:0100721)2.13128330
6911 pairs of ribs (HP:0000878)2.12931951
70Premature rupture of membranes (HP:0001788)2.11378718
71Abnormality of T cell number (HP:0011839)2.11045739
72Abnormality of the tricuspid valve (HP:0001702)2.10622082
73Duodenal stenosis (HP:0100867)2.10445396
74Small intestinal stenosis (HP:0012848)2.10445396
75Abnormality of cells of the lymphoid lineage (HP:0012140)2.09807141
76Deep palmar crease (HP:0006191)2.08797558
77Microvesicular hepatic steatosis (HP:0001414)2.08708102
78Abnormality of the calcaneus (HP:0008364)2.08201701
79Abnormality of reticulocytes (HP:0004312)2.07860845
80Recurrent fungal infections (HP:0002841)2.07482433
81Recurrent bronchitis (HP:0002837)2.06047051
82Meckel diverticulum (HP:0002245)2.05854205
83Abnormal neuron morphology (HP:0012757)2.05676684
84Abnormality of the motor neurons (HP:0002450)2.05676684
85Sparse lateral eyebrow (HP:0005338)2.05059251
86Abnormality of B cell number (HP:0010975)2.03428304
87B lymphocytopenia (HP:0010976)2.03428304
88Macrocytic anemia (HP:0001972)2.03427634
89Pelvic girdle muscle weakness (HP:0003749)2.02677805
90Combined immunodeficiency (HP:0005387)2.01839324
91Premature skin wrinkling (HP:0100678)2.01832808
92Lymphopenia (HP:0001888)2.00976965
93Premature graying of hair (HP:0002216)2.00972985
94Deviation of the thumb (HP:0009603)2.00937742
95Hypoplasia of the pons (HP:0012110)1.98687953
96Megaloblastic anemia (HP:0001889)1.97566066
97Medulloblastoma (HP:0002885)1.97056719
98Distal lower limb muscle weakness (HP:0009053)1.97000334
99Abnormality of the ileum (HP:0001549)1.96697609
100Proximal placement of thumb (HP:0009623)1.96202146
101Horseshoe kidney (HP:0000085)1.94782448
102Cafe-au-lait spot (HP:0000957)1.94706760
103Chromsome breakage (HP:0040012)1.94338154
104Back pain (HP:0003418)1.94095497
105Recurrent abscess formation (HP:0002722)1.93506327
106Breech presentation (HP:0001623)1.93329611
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.92365198
108Abnormal trabecular bone morphology (HP:0100671)1.92000161
109Hypertensive crisis (HP:0100735)1.91684405
110Panhypogammaglobulinemia (HP:0003139)1.91119623
111Abnormality of T cell physiology (HP:0011840)1.90233567
112Premature ovarian failure (HP:0008209)1.89734392
113Septate vagina (HP:0001153)1.89253814
114Absent thumb (HP:0009777)1.88766589
115Protrusio acetabuli (HP:0003179)1.87403107
116Squamous cell carcinoma (HP:0002860)1.86185032
117Asymmetry of the thorax (HP:0001555)1.85176392
118High pitched voice (HP:0001620)1.85044496
119Chronic otitis media (HP:0000389)1.84148960
120Abnormal umbilical cord blood vessels (HP:0011403)1.83780079
121Single umbilical artery (HP:0001195)1.83780079
122Abnormality of the fetal cardiovascular system (HP:0010948)1.83780079
123IgG deficiency (HP:0004315)1.81814380
124Fragile skin (HP:0001030)1.81320394
125Spastic diplegia (HP:0001264)1.81289294
126Petechiae (HP:0000967)1.81040930
127Small epiphyses (HP:0010585)1.80857318
128Tracheoesophageal fistula (HP:0002575)1.80493121
129Hypoparathyroidism (HP:0000829)1.78938359
130Teleangiectasia of the skin (HP:0100585)1.78498627
131Patellar dislocation (HP:0002999)1.78093293
132Abnormalities of placenta or umbilical cord (HP:0001194)1.77017006
133Distal upper limb amyotrophy (HP:0007149)1.76917565
134Upper limb amyotrophy (HP:0009129)1.76917565
135Leukopenia (HP:0001882)1.76731445
136Abnormality of the duodenum (HP:0002246)1.76687966
137Progressive muscle weakness (HP:0003323)1.76651463
138Abnormality of skeletal muscle fiber size (HP:0012084)1.76613562
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75843289
140Absent epiphyses (HP:0010577)1.75843289
141Generalized amyotrophy (HP:0003700)1.74634638
142Rhabdomyosarcoma (HP:0002859)1.73747887
143Cholelithiasis (HP:0001081)1.73641329
144Shoulder girdle muscle weakness (HP:0003547)1.73540502
145Deformed tarsal bones (HP:0008119)1.73537713
146Cleft eyelid (HP:0000625)1.72917332
147Postnatal microcephaly (HP:0005484)1.72470586
148Exercise-induced myalgia (HP:0003738)1.71753084
149Severe combined immunodeficiency (HP:0004430)1.71470586
150Angiofibromas (HP:0010615)1.71083494
151Adenoma sebaceum (HP:0009720)1.71083494
152Recurrent bacterial skin infections (HP:0005406)1.70821558
153Overriding aorta (HP:0002623)1.69914352
154Hyperthyroidism (HP:0000836)1.69640015
155Reticulocytosis (HP:0001923)1.69513152
156Unilateral renal agenesis (HP:0000122)1.69437722
157Abnormality of glycolysis (HP:0004366)1.69437163
158Abnormal ventriculo-arterial connection (HP:0011563)1.67765229
159Transposition of the great arteries (HP:0001669)1.67765229
160Abnormal connection of the cardiac segments (HP:0011545)1.67765229
161High anterior hairline (HP:0009890)1.67650152
162Elbow flexion contracture (HP:0002987)1.67536855
163Hyperparathyroidism (HP:0000843)1.66797841
164Orthostatic hypotension (HP:0001278)1.66508915
165Disproportionate tall stature (HP:0001519)1.66428656
166Spinal rigidity (HP:0003306)1.65726205
167Stridor (HP:0010307)1.64952225
168Congenital malformation of the right heart (HP:0011723)1.64259926
169Double outlet right ventricle (HP:0001719)1.64259926
170Seborrheic dermatitis (HP:0001051)1.63411161
171Metatarsus adductus (HP:0001840)1.62652349
172Abnormality of dentin (HP:0010299)1.60650929
173Difficulty climbing stairs (HP:0003551)1.59761058
174Spinal cord lesions (HP:0100561)1.59541648
175Syringomyelia (HP:0003396)1.59541648
176Increased nuchal translucency (HP:0010880)1.59078283
177Bulbar palsy (HP:0001283)1.58928435
178Increased variability in muscle fiber diameter (HP:0003557)1.57024737
179Lower limb amyotrophy (HP:0007210)1.56894329
180Dysphonia (HP:0001618)1.56831968
181Renal duplication (HP:0000075)1.56370006
182Cellulitis (HP:0100658)1.56100453
183Increased intramyocellular lipid droplets (HP:0012240)1.54793245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.89043941
2BUB14.56341306
3WEE13.59384138
4IRAK33.24263590
5CDC73.07832973
6VRK22.99332149
7TSSK62.85766864
8EIF2AK12.84262041
9PRPF4B2.67659290
10MAP4K12.66964757
11EIF2AK32.63507125
12ICK2.59570873
13BRSK22.51690240
14NEK22.32240495
15ACVR1B2.08652168
16CCNB12.04007850
17NEK11.93760349
18SCYL21.75409513
19SIK11.72345768
20STK161.71043884
21PKN21.67003519
22MAP3K101.65100785
23BRSK11.60940535
24SRPK11.56656104
25PLK11.55944683
26TTK1.54922380
27TAF11.53055667
28STK101.52859982
29PIM21.51650321
30TESK11.51512613
31PLK31.44993428
32EEF2K1.44807485
33RPS6KA41.40746574
34DAPK11.40597302
35NME21.38125902
36TAOK21.36480940
37CDK41.34732478
38RPS6KB21.33744923
39ATR1.33440750
40PBK1.33179261
41TTN1.32383193
42ERN11.31658090
43AURKB1.29009948
44GRK61.28257202
45PLK41.25677980
46PRKD31.25012151
47TNIK1.19816753
48MAP3K81.19753220
49JAK31.18655274
50VRK11.16631512
51DYRK31.14125415
52CDK121.13674677
53FLT31.13039845
54PAK41.09819534
55CSF1R1.07840475
56CDK71.06833769
57MAP2K31.02316883
58BTK1.01499043
59MELK1.00007784
60LATS20.99663438
61MKNK10.99477710
62PASK0.98362783
63MTOR0.97539056
64CHEK10.96458052
65EPHA20.94320955
66ALK0.93328669
67RAF10.93120618
68LRRK20.89473205
69TYK20.89163946
70PIM10.86639070
71CDK80.85149844
72ARAF0.84278274
73TRIB30.82800602
74CHEK20.82472717
75IRAK20.81768071
76MAPK110.81489151
77TGFBR10.79715192
78ZAP700.79573244
79SYK0.79169582
80ILK0.78444686
81CDK90.77307281
82FGFR40.77198059
83MARK30.75693729
84AKT20.75629968
85PDGFRA0.75174471
86AURKA0.74631012
87RIPK10.72640183
88BRD40.71117132
89TXK0.70445827
90RIPK40.70332086
91KIT0.69686629
92CDK20.68440735
93MKNK20.67692366
94PDK20.67465254
95ZAK0.66477975
96MAP3K110.64473464
97TLK10.62129619
98CDK60.61058294
99MAP3K140.60962877
100NLK0.59097563
101ATM0.58639127
102PDPK10.58562829
103IKBKB0.58087617
104PAK10.57799308
105CLK10.55204354
106CSNK2A20.54668877
107KSR20.54447663
108CAMKK20.54304344
109MST1R0.54257852
110DAPK30.53014023
111IRAK40.51523583
112PRKCI0.51308014
113EIF2AK20.50885227
114CAMK1D0.50855767
115CDK11A0.50583319
116BMX0.48840698
117STK40.48315372
118TESK20.47776877
119LYN0.46838418
120SIK20.46414531
121MAP2K20.46132699
122TBK10.45478428
123MAP3K130.45410605
124ERBB40.45319714
125PTK20.45042917
126MOS0.43699863
127ABL20.43563531
128PRKD20.43449734
129TAOK10.43310881
130PAK20.43253372
131KDR0.42695176
132FGFR10.42338124
133NTRK30.42066881
134BRAF0.41486325
135PTK60.41310129
136MAP3K10.41074372
137CSNK2A10.40779156
138CDK150.40541121
139CHUK0.40211685
140CDK10.39916160
141MAP3K50.39442544
142RPS6KC10.38682556
143RPS6KL10.38682556
144MST40.38361306
145MAP3K90.38278774
146LCK0.36603223
147NEK90.34889043
148DAPK20.34237397
149PDK30.34228843
150PDK40.34228843
151TEC0.32882417

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.64177603
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84354844
3Mismatch repair_Homo sapiens_hsa034303.52999551
4Proteasome_Homo sapiens_hsa030503.51204766
5Spliceosome_Homo sapiens_hsa030403.21809128
6RNA polymerase_Homo sapiens_hsa030203.12506600
7RNA transport_Homo sapiens_hsa030132.99694270
8Base excision repair_Homo sapiens_hsa034102.81217750
9Ribosome_Homo sapiens_hsa030102.68908071
10One carbon pool by folate_Homo sapiens_hsa006702.47641390
11Cell cycle_Homo sapiens_hsa041102.46176905
12Nucleotide excision repair_Homo sapiens_hsa034202.35822869
13Pyrimidine metabolism_Homo sapiens_hsa002402.35170916
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32739208
15Homologous recombination_Homo sapiens_hsa034402.27297479
16Non-homologous end-joining_Homo sapiens_hsa034501.70927037
17Antigen processing and presentation_Homo sapiens_hsa046121.62781451
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60409919
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59237104
20RNA degradation_Homo sapiens_hsa030181.55531008
21Epstein-Barr virus infection_Homo sapiens_hsa051691.54366816
22p53 signaling pathway_Homo sapiens_hsa041151.47608950
23Primary immunodeficiency_Homo sapiens_hsa053401.44033157
24Other glycan degradation_Homo sapiens_hsa005111.43560420
25Biosynthesis of amino acids_Homo sapiens_hsa012301.38113473
26Pentose phosphate pathway_Homo sapiens_hsa000301.37317253
27Legionellosis_Homo sapiens_hsa051341.37183491
28Fanconi anemia pathway_Homo sapiens_hsa034601.35585607
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.32466244
30Folate biosynthesis_Homo sapiens_hsa007901.32140772
31mRNA surveillance pathway_Homo sapiens_hsa030151.31101808
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28956083
33Herpes simplex infection_Homo sapiens_hsa051681.18777341
34Pancreatic cancer_Homo sapiens_hsa052121.11809423
35Purine metabolism_Homo sapiens_hsa002301.10754681
36Basal transcription factors_Homo sapiens_hsa030221.09132434
37Oocyte meiosis_Homo sapiens_hsa041141.07492027
38Vitamin B6 metabolism_Homo sapiens_hsa007501.03947255
39Notch signaling pathway_Homo sapiens_hsa043301.02030807
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.01287916
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00305607
42Viral carcinogenesis_Homo sapiens_hsa052031.00100643
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99530083
44Pyruvate metabolism_Homo sapiens_hsa006200.96861700
45Thyroid cancer_Homo sapiens_hsa052160.94511425
46Measles_Homo sapiens_hsa051620.88974906
47Sulfur relay system_Homo sapiens_hsa041220.88255850
48Endometrial cancer_Homo sapiens_hsa052130.86623127
49HTLV-I infection_Homo sapiens_hsa051660.86194716
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83486389
51B cell receptor signaling pathway_Homo sapiens_hsa046620.82140231
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.82008493
53Apoptosis_Homo sapiens_hsa042100.81131114
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79404804
55Prion diseases_Homo sapiens_hsa050200.78861038
56Carbon metabolism_Homo sapiens_hsa012000.76615892
57Vibrio cholerae infection_Homo sapiens_hsa051100.73200298
58Insulin signaling pathway_Homo sapiens_hsa049100.71012361
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70334174
60Hepatitis B_Homo sapiens_hsa051610.70152631
61Systemic lupus erythematosus_Homo sapiens_hsa053220.70036803
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67176337
63Leishmaniasis_Homo sapiens_hsa051400.67024813
64Influenza A_Homo sapiens_hsa051640.66084958
65Fructose and mannose metabolism_Homo sapiens_hsa000510.65386644
66Glioma_Homo sapiens_hsa052140.64537408
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.63308742
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62915830
69mTOR signaling pathway_Homo sapiens_hsa041500.62749122
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62339414
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61941904
72Prostate cancer_Homo sapiens_hsa052150.61383920
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59856930
74Renal cell carcinoma_Homo sapiens_hsa052110.59543851
75Arginine and proline metabolism_Homo sapiens_hsa003300.58262282
76Shigellosis_Homo sapiens_hsa051310.58253717
77T cell receptor signaling pathway_Homo sapiens_hsa046600.57989891
78HIF-1 signaling pathway_Homo sapiens_hsa040660.57155875
79Selenocompound metabolism_Homo sapiens_hsa004500.56960159
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56462908
81AMPK signaling pathway_Homo sapiens_hsa041520.55445204
82Hematopoietic cell lineage_Homo sapiens_hsa046400.53746081
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52970277
84Galactose metabolism_Homo sapiens_hsa000520.52788919
85Lysine degradation_Homo sapiens_hsa003100.52052871
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51376758
87Tuberculosis_Homo sapiens_hsa051520.49405663
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48393011
89Arginine biosynthesis_Homo sapiens_hsa002200.48269283
90ErbB signaling pathway_Homo sapiens_hsa040120.47098334
91Proteoglycans in cancer_Homo sapiens_hsa052050.46940607
92Acute myeloid leukemia_Homo sapiens_hsa052210.46320251
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45794398
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45743471
95Hepatitis C_Homo sapiens_hsa051600.44038881
96Chronic myeloid leukemia_Homo sapiens_hsa052200.43393485
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43123823
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.42527370
99Colorectal cancer_Homo sapiens_hsa052100.41825431
100Small cell lung cancer_Homo sapiens_hsa052220.41222402
101Glutathione metabolism_Homo sapiens_hsa004800.40203872
102N-Glycan biosynthesis_Homo sapiens_hsa005100.39015668
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38882162
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.38436749
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38224760
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38066372
107Type I diabetes mellitus_Homo sapiens_hsa049400.37290944
108Huntingtons disease_Homo sapiens_hsa050160.36677000
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35799741
110Non-small cell lung cancer_Homo sapiens_hsa052230.35382417
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35129771
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33587981
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33035984
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33015215
115Regulation of autophagy_Homo sapiens_hsa041400.32032204
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31915121
117Osteoclast differentiation_Homo sapiens_hsa043800.31534546
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29478818
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25825506
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25761079
121Allograft rejection_Homo sapiens_hsa053300.23549649
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23086476
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.21312630
124MicroRNAs in cancer_Homo sapiens_hsa052060.21273807
125TNF signaling pathway_Homo sapiens_hsa046680.19076552
126VEGF signaling pathway_Homo sapiens_hsa043700.19076138
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18320633
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17540610
129Bladder cancer_Homo sapiens_hsa052190.16348814
130Asthma_Homo sapiens_hsa053100.16171739
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15825289

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