REXO1L2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)7.85586296
2regulation of transmission of nerve impulse (GO:0051969)7.57189038
3fusion of sperm to egg plasma membrane (GO:0007342)7.31067407
4piRNA metabolic process (GO:0034587)5.97564824
5response to pheromone (GO:0019236)5.90433243
6plasma membrane fusion (GO:0045026)5.86764181
7positive regulation of action potential (GO:0045760)5.21534892
8positive regulation of catecholamine secretion (GO:0033605)5.15742497
9negative regulation of appetite (GO:0032099)5.09220286
10negative regulation of response to food (GO:0032096)5.09220286
11adult feeding behavior (GO:0008343)5.00922674
12regulation of gene silencing by RNA (GO:0060966)4.57756860
13regulation of posttranscriptional gene silencing (GO:0060147)4.57756860
14regulation of gene silencing by miRNA (GO:0060964)4.57756860
15cilium or flagellum-dependent cell motility (GO:0001539)4.41896239
16organic cation transport (GO:0015695)4.38103318
17regulation of cytokine production involved in inflammatory response (GO:1900015)4.18379397
18phosphatidylinositol acyl-chain remodeling (GO:0036149)4.13135237
19regulation of acrosome reaction (GO:0060046)4.12201658
20regulation of rhodopsin mediated signaling pathway (GO:0022400)4.09510370
21NIK/NF-kappaB signaling (GO:0038061)4.08489588
22ribosomal small subunit assembly (GO:0000028)4.08236219
23positive regulation of neurological system process (GO:0031646)4.05352677
24neuronal action potential (GO:0019228)4.04568294
25negative regulation of bone resorption (GO:0045779)4.04103507
26phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.97428872
27motile cilium assembly (GO:0044458)3.93140091
28indolalkylamine metabolic process (GO:0006586)3.91351552
29phosphatidylserine acyl-chain remodeling (GO:0036150)3.87827945
30cellular response to exogenous dsRNA (GO:0071360)3.83992850
31seminiferous tubule development (GO:0072520)3.81630436
32histamine secretion (GO:0001821)3.77176909
33rhodopsin mediated signaling pathway (GO:0016056)3.71228577
34male meiosis I (GO:0007141)3.64694291
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.64127145
36post-embryonic morphogenesis (GO:0009886)3.61632806
37phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.53541154
38sulfation (GO:0051923)3.49269935
39indole-containing compound metabolic process (GO:0042430)3.43583943
40digestion (GO:0007586)3.43297135
41tryptophan metabolic process (GO:0006568)3.42924454
42transmission of nerve impulse (GO:0019226)3.36538463
43protein K48-linked deubiquitination (GO:0071108)3.33917935
44L-fucose catabolic process (GO:0042355)3.33367496
45fucose catabolic process (GO:0019317)3.33367496
46L-fucose metabolic process (GO:0042354)3.33367496
47regulation of appetite (GO:0032098)3.30772270
48adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.24796251
49long term synaptic depression (GO:0060292)3.22942089
50synaptic transmission, dopaminergic (GO:0001963)3.21511284
51regulation of action potential (GO:0098900)3.21236069
52fat-soluble vitamin biosynthetic process (GO:0042362)3.18006461
53negative regulation of bone remodeling (GO:0046851)3.15050176
54sperm motility (GO:0030317)3.10000243
55axoneme assembly (GO:0035082)3.09223778
56epithelial cilium movement (GO:0003351)3.05128454
57GTP biosynthetic process (GO:0006183)3.04358537
58DNA methylation involved in gamete generation (GO:0043046)3.04085964
59regulation of response to food (GO:0032095)3.01379439
60multicellular organism reproduction (GO:0032504)2.98797627
61peristalsis (GO:0030432)2.98108621
62cell wall macromolecule metabolic process (GO:0044036)2.97217859
63positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.94906466
64phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.89981796
65cilium movement (GO:0003341)2.88169301
66regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85591683
67histamine transport (GO:0051608)2.84823778
68DNA damage response, detection of DNA damage (GO:0042769)2.82135003
69histone H3-K9 methylation (GO:0051567)2.80154672
70negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.79360998
71intestinal absorption (GO:0050892)2.77826526
72oogenesis (GO:0048477)2.77614768
73cell morphogenesis involved in neuron differentiation (GO:0048667)2.77317020
74ribosomal large subunit biogenesis (GO:0042273)2.75413880
75meiosis I (GO:0007127)2.75199741
76regulation of RIG-I signaling pathway (GO:0039535)2.74436446
77imidazole-containing compound metabolic process (GO:0052803)2.71669398
78dopamine transport (GO:0015872)2.70559613
79phosphatidylcholine acyl-chain remodeling (GO:0036151)2.69940712
80detection of light stimulus involved in visual perception (GO:0050908)2.68760126
81detection of light stimulus involved in sensory perception (GO:0050962)2.68760126
82acrosome reaction (GO:0007340)2.67748149
83regulation of ruffle assembly (GO:1900027)2.65355898
84protein polyglutamylation (GO:0018095)2.64942124
85I-kappaB phosphorylation (GO:0007252)2.63930198
86histone H3-K9 modification (GO:0061647)2.62051102
87G-protein coupled receptor internalization (GO:0002031)2.58887594
88behavioral response to nicotine (GO:0035095)2.56210032
89negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.54908903
90negative regulation of gene silencing (GO:0060969)2.52307268
91termination of G-protein coupled receptor signaling pathway (GO:0038032)2.51960306
92B cell receptor signaling pathway (GO:0050853)2.51405067
93establishment of protein localization to Golgi (GO:0072600)2.50851702
94UTP biosynthetic process (GO:0006228)2.49212709
95negative regulation of synaptic transmission, GABAergic (GO:0032229)2.48968843
96macroautophagy (GO:0016236)2.47702248
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47638151
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.47638151
99NADH dehydrogenase complex assembly (GO:0010257)2.47638151
100negative regulation of sodium ion transport (GO:0010766)2.47507310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.65126243
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.53861369
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.78872703
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.72499431
5* VDR_22108803_ChIP-Seq_LS180_Human3.40523894
6IGF1R_20145208_ChIP-Seq_DFB_Human3.27906526
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91215269
8GBX2_23144817_ChIP-Seq_PC3_Human2.88558113
9* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.49973899
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.42718996
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.22411557
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17866841
13ZNF274_21170338_ChIP-Seq_K562_Hela2.16274332
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11355567
15* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01616147
16TAF15_26573619_Chip-Seq_HEK293_Human1.97799958
17FUS_26573619_Chip-Seq_HEK293_Human1.90403882
18DROSHA_22980978_ChIP-Seq_HELA_Human1.87402759
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81004908
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77217561
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64059977
22* ER_23166858_ChIP-Seq_MCF-7_Human1.61520384
23REST_21632747_ChIP-Seq_MESCs_Mouse1.60085428
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59419173
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58221916
26* P300_19829295_ChIP-Seq_ESCs_Human1.52432190
27EWS_26573619_Chip-Seq_HEK293_Human1.48920737
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47299218
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44429612
30CBP_20019798_ChIP-Seq_JUKART_Human1.44429612
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.39670880
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33687985
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32176294
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30300510
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.30300510
36STAT3_23295773_ChIP-Seq_U87_Human1.28962193
37* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28623866
38AR_20517297_ChIP-Seq_VCAP_Human1.27993302
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27782058
40ERG_20517297_ChIP-Seq_VCAP_Human1.25497075
41OCT4_20526341_ChIP-Seq_ESCs_Human1.25377670
42SOX2_19829295_ChIP-Seq_ESCs_Human1.24023279
43NANOG_19829295_ChIP-Seq_ESCs_Human1.24023279
44AR_25329375_ChIP-Seq_VCAP_Human1.21703166
45ETV1_20927104_ChIP-Seq_GIST48_Human1.21686082
46TP53_22573176_ChIP-Seq_HFKS_Human1.21681144
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18372663
48SMAD4_21799915_ChIP-Seq_A2780_Human1.18284784
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17759591
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.17278622
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.14951154
52TCF4_23295773_ChIP-Seq_U87_Human1.14052841
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13937417
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.13397636
55RAC3_21632823_ChIP-Seq_H3396_Human1.12282035
56CBX2_22325352_ChIP-Seq_293T-Rex_Human1.12139850
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11331285
58* RUNX2_22187159_ChIP-Seq_PCA_Human1.10928651
59NFYB_21822215_ChIP-Seq_K562_Human1.10837110
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10341403
61NCOR_22424771_ChIP-Seq_293T_Human1.10141412
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09710937
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09259306
64NFYA_21822215_ChIP-Seq_K562_Human1.08349083
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08219949
66NANOG_20526341_ChIP-Seq_ESCs_Human1.07029865
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06949800
68EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05376062
69PHF8_20622853_ChIP-Seq_HELA_Human1.05064486
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04643416
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.04467621
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.04251664
73WDR5_24793694_ChIP-Seq_LNCAP_Human1.03891222
74HNFA_21074721_ChIP-Seq_CACO-2_Human1.03036764
75CEBPB_22108803_ChIP-Seq_LS180_Human1.02843383
76* BCAT_22108803_ChIP-Seq_LS180_Human1.02757352
77AR_21572438_ChIP-Seq_LNCaP_Human1.02724231
78TBL1_22424771_ChIP-Seq_293T_Human1.02319457
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02282289
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02275559
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00728760
82* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00304661
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00288286
84RBPJ_21746931_ChIP-Seq_IB4_Human1.00208412
85TAF2_19829295_ChIP-Seq_ESCs_Human0.98530652
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.97837738
87RNF2_27304074_Chip-Seq_NSC_Mouse0.97793456
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97081384
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96689503
90REST_18959480_ChIP-ChIP_MESCs_Mouse0.95928742
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95507192
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94995740
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94680136
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93201321
95* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93046090
96IRF8_21731497_ChIP-ChIP_J774_Mouse0.92556309
97EGR1_19032775_ChIP-ChIP_M12_Human0.92363510
98GATA3_26560356_Chip-Seq_TH2_Human0.92155539
99OCT1_27270436_Chip-Seq_PROSTATE_Human0.91908724
100* HOXB7_26014856_ChIP-Seq_BT474_Human0.91810648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption3.35370034
2MP0005410_abnormal_fertilization3.24529132
3MP0003878_abnormal_ear_physiology3.06265254
4MP0005377_hearing/vestibular/ear_phenot3.06265254
5MP0005551_abnormal_eye_electrophysiolog2.90932832
6MP0005365_abnormal_bile_salt2.86549441
7MP0006072_abnormal_retinal_apoptosis2.79888190
8MP0003806_abnormal_nucleotide_metabolis2.65833496
9MP0002138_abnormal_hepatobiliary_system2.60838067
10MP0003950_abnormal_plasma_membrane2.50771054
11MP0001968_abnormal_touch/_nociception2.40725738
12MP0003283_abnormal_digestive_organ2.15676819
13MP0002332_abnormal_exercise_endurance1.99862090
14MP0005253_abnormal_eye_physiology1.93173091
15MP0006292_abnormal_olfactory_placode1.92550790
16MP0005670_abnormal_white_adipose1.92098963
17MP0003195_calcinosis1.87634149
18MP0003959_abnormal_lean_body1.79307155
19MP0003183_abnormal_peptide_metabolism1.74986490
20MP0002095_abnormal_skin_pigmentation1.73547753
21MP0005085_abnormal_gallbladder_physiolo1.72475097
22MP0001293_anophthalmia1.68958328
23MP0008875_abnormal_xenobiotic_pharmacok1.68923787
24MP0003879_abnormal_hair_cell1.66979422
25MP0003136_yellow_coat_color1.66313437
26MP0005448_abnormal_energy_balance1.62005056
27MP0010386_abnormal_urinary_bladder1.59940788
28MP0006276_abnormal_autonomic_nervous1.58233005
29MP0009745_abnormal_behavioral_response1.57277088
30MP0003646_muscle_fatigue1.56687305
31MP0005075_abnormal_melanosome_morpholog1.56410379
32MP0008877_abnormal_DNA_methylation1.55804187
33MP0003698_abnormal_male_reproductive1.53506491
34MP0001790_abnormal_immune_system1.51597612
35MP0005387_immune_system_phenotype1.51597612
36MP0002736_abnormal_nociception_after1.47141375
37MP0009379_abnormal_foot_pigmentation1.46569641
38MP0001485_abnormal_pinna_reflex1.41234414
39MP0001486_abnormal_startle_reflex1.41129686
40MP0001986_abnormal_taste_sensitivity1.39041021
41MP0001929_abnormal_gametogenesis1.36349543
42MP0002102_abnormal_ear_morphology1.36187632
43MP0002229_neurodegeneration1.36020788
44MP0003011_delayed_dark_adaptation1.30946799
45MP0002272_abnormal_nervous_system1.30480692
46MP0000465_gastrointestinal_hemorrhage1.29645704
47MP0002067_abnormal_sensory_capabilities1.28618109
48MP0005266_abnormal_metabolism1.28222996
49MP0002572_abnormal_emotion/affect_behav1.24620627
50MP0002928_abnormal_bile_duct1.24458714
51MP0002693_abnormal_pancreas_physiology1.23475429
52MP0003868_abnormal_feces_composition1.23410588
53MP0005671_abnormal_response_to1.19919790
54MP0001664_abnormal_digestion1.17059462
55MP0008872_abnormal_physiological_respon1.15763142
56MP0004147_increased_porphyrin_level1.14334879
57MP0002210_abnormal_sex_determination1.13375764
58MP0008995_early_reproductive_senescence1.13327539
59MP0005503_abnormal_tendon_morphology1.12571478
60MP0002064_seizures1.11310604
61MP0004885_abnormal_endolymph1.10434905
62MP0002837_dystrophic_cardiac_calcinosis1.09800073
63MP0004043_abnormal_pH_regulation1.06857806
64MP0000427_abnormal_hair_cycle1.05119166
65MP0005171_absent_coat_pigmentation1.02315836
66MP0005645_abnormal_hypothalamus_physiol1.01941014
67MP0005391_vision/eye_phenotype1.01052226
68MP0002909_abnormal_adrenal_gland1.00962805
69MP0005195_abnormal_posterior_eye1.00169006
70MP0002734_abnormal_mechanical_nocicepti0.99732010
71MP0000372_irregular_coat_pigmentation0.98845267
72MP0001873_stomach_inflammation0.98771858
73MP0005310_abnormal_salivary_gland0.98378856
74MP0002876_abnormal_thyroid_physiology0.97998866
75MP0005084_abnormal_gallbladder_morpholo0.97925948
76MP0002733_abnormal_thermal_nociception0.95803478
77MP0002557_abnormal_social/conspecific_i0.93468453
78MP0010329_abnormal_lipoprotein_level0.93456188
79MP0009643_abnormal_urine_homeostasis0.92308821
80MP0001970_abnormal_pain_threshold0.90867985
81MP0001145_abnormal_male_reproductive0.90800235
82MP0005167_abnormal_blood-brain_barrier0.90536580
83MP0003172_abnormal_lysosome_physiology0.88286417
84MP0003941_abnormal_skin_development0.87618729
85MP0003137_abnormal_impulse_conducting0.86264653
86MP0000653_abnormal_sex_gland0.86240931
87MP0004019_abnormal_vitamin_homeostasis0.85100358
88MP0001765_abnormal_ion_homeostasis0.84626035
89MP0003252_abnormal_bile_duct0.83665784
90MP0003635_abnormal_synaptic_transmissio0.82003343
91MP0005174_abnormal_tail_pigmentation0.81115076
92MP0002139_abnormal_hepatobiliary_system0.80412264
93MP0000538_abnormal_urinary_bladder0.79923680
94MP0008004_abnormal_stomach_pH0.78742578
95MP0003567_abnormal_fetal_cardiomyocyte0.76854858
96MP0001879_abnormal_lymphatic_vessel0.76192834
97MP0002638_abnormal_pupillary_reflex0.75474789
98MP0002136_abnormal_kidney_physiology0.75411283
99MP0005535_abnormal_body_temperature0.75003948
100MP0000681_abnormal_thyroid_gland0.71394551

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)8.41607050
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.41607050
3Congenital stationary night blindness (HP:0007642)5.42021647
4Abnormal ciliary motility (HP:0012262)5.33636716
5Chronic hepatic failure (HP:0100626)5.27311862
6Protruding tongue (HP:0010808)4.99620868
7Atonic seizures (HP:0010819)4.86645739
8Agammaglobulinemia (HP:0004432)4.80310392
9Abnormal respiratory epithelium morphology (HP:0012253)4.75286594
10Abnormal respiratory motile cilium morphology (HP:0005938)4.75286594
11Abnormal respiratory motile cilium physiology (HP:0012261)3.88305510
12Tubulointerstitial nephritis (HP:0001970)3.67444911
13Hemiplegia (HP:0002301)3.42851136
14Pancreatic cysts (HP:0001737)3.39347192
15Abolished electroretinogram (ERG) (HP:0000550)3.32696484
16Infantile muscular hypotonia (HP:0008947)3.29814127
17Congenital sensorineural hearing impairment (HP:0008527)3.27015028
18Panhypogammaglobulinemia (HP:0003139)3.24376709
19Abnormality of midbrain morphology (HP:0002418)3.23795259
20Molar tooth sign on MRI (HP:0002419)3.23795259
21Agitation (HP:0000713)3.21438174
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.17812738
23Chronic otitis media (HP:0000389)3.12374876
243-Methylglutaconic aciduria (HP:0003535)3.03136537
25Abnormality of the prostate (HP:0008775)3.00228202
26Attenuation of retinal blood vessels (HP:0007843)2.93708899
27Abnormality of the right ventricle (HP:0001707)2.90409469
28Persistence of primary teeth (HP:0006335)2.89030103
29Delayed CNS myelination (HP:0002188)2.79974627
30Hyperventilation (HP:0002883)2.73783334
31Clumsiness (HP:0002312)2.73643210
32Chronic sinusitis (HP:0011109)2.71049529
33Increased cerebral lipofuscin (HP:0011813)2.64489340
34Cystic liver disease (HP:0006706)2.61612290
35Azoospermia (HP:0000027)2.59283918
36Dialeptic seizures (HP:0011146)2.57900994
37Subcapsular cataract (HP:0000523)2.54348242
38Portal hypertension (HP:0001409)2.48656648
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41760526
40Recurrent sinusitis (HP:0011108)2.41332816
41Exocrine pancreatic insufficiency (HP:0001738)2.41257025
42Bony spicule pigmentary retinopathy (HP:0007737)2.38351089
43Febrile seizures (HP:0002373)2.35942427
44Elevated erythrocyte sedimentation rate (HP:0003565)2.35705204
45Prostate neoplasm (HP:0100787)2.33226360
46Abnormal spermatogenesis (HP:0008669)2.33176434
47Abnormality of lateral ventricle (HP:0030047)2.31305300
48Abnormality of the hepatic vasculature (HP:0006707)2.29231287
49Absence seizures (HP:0002121)2.19619106
50Pancreatic fibrosis (HP:0100732)2.16452117
51Tubulointerstitial abnormality (HP:0001969)2.15496090
52Amyotrophic lateral sclerosis (HP:0007354)2.14583294
53Posterior subcapsular cataract (HP:0007787)2.13881027
54Nephronophthisis (HP:0000090)2.13541449
55Difficulty walking (HP:0002355)2.12875821
56True hermaphroditism (HP:0010459)2.10184479
57Congenital hepatic fibrosis (HP:0002612)2.08135021
58Retinal dysplasia (HP:0007973)2.01447544
59Medial flaring of the eyebrow (HP:0010747)2.01070155
60Tongue fasciculations (HP:0001308)1.99876788
61Broad alveolar ridges (HP:0000187)1.96923082
62Facial hemangioma (HP:0000329)1.96702920
63Keratoconus (HP:0000563)1.95033092
64Increased corneal curvature (HP:0100692)1.95033092
65Hepatocellular necrosis (HP:0001404)1.94630991
66Thoracic kyphosis (HP:0002942)1.94135327
67Recurrent pneumonia (HP:0006532)1.92662554
68Abnormality of the renal medulla (HP:0100957)1.92446079
69Encephalitis (HP:0002383)1.91562270
70Hypoproteinemia (HP:0003075)1.91405876
71Recurrent bacterial skin infections (HP:0005406)1.90715885
72Poor eye contact (HP:0000817)1.89030665
73Hypoalbuminemia (HP:0003073)1.88932664
74Abnormal albumin level (HP:0012116)1.88932664
75Muscle fibrillation (HP:0010546)1.88131878
76Polar cataract (HP:0010696)1.88103459
77Cellulitis (HP:0100658)1.84528564
78Amelogenesis imperfecta (HP:0000705)1.84522599
79Abnormality of male internal genitalia (HP:0000022)1.83146005
80Reduced antithrombin III activity (HP:0001976)1.82862290
81Focal seizures (HP:0007359)1.81720726
82Abnormality of dental color (HP:0011073)1.79863884
83Recurrent bronchitis (HP:0002837)1.79564044
84Supernumerary spleens (HP:0009799)1.78104650
85Prolonged QT interval (HP:0001657)1.77237560
86Choroideremia (HP:0001139)1.76794136
87Abnormality of the renal cortex (HP:0011035)1.74784033
88Abnormality of purine metabolism (HP:0004352)1.73115241
89Increased CSF lactate (HP:0002490)1.72453389
90Autoimmune thrombocytopenia (HP:0001973)1.72162158
91Fair hair (HP:0002286)1.71748574
92Gait imbalance (HP:0002141)1.70880903
93Progressive microcephaly (HP:0000253)1.70066420
94Hypothermia (HP:0002045)1.69197865
95Adactyly (HP:0009776)1.67542123
96Sclerocornea (HP:0000647)1.66711035
97Concave nail (HP:0001598)1.65218989
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.62956900
99Progressive external ophthalmoplegia (HP:0000590)1.62447046
100Visual hallucinations (HP:0002367)1.60725266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK29.30256668
2STK165.33937478
3INSRR5.03356097
4GRK14.03475076
5SIK22.72952768
6LATS12.41179635
7NUAK12.38477754
8MAPKAPK32.24923456
9TIE12.21890172
10ITK2.19466842
11TEC2.05674064
12EIF2AK31.93109472
13KDR1.81764019
14BMPR1B1.78330783
15MAP2K61.65930974
16ADRBK21.54677529
17DAPK11.42155692
18DAPK21.41241952
19ACVR1B1.41147347
20PIK3CG1.28273285
21CCNB11.27114165
22PLK41.26443162
23SYK1.25632044
24IKBKE1.25589529
25FRK1.25322774
26TNIK1.21304222
27TAF11.19465138
28ZAK1.03068734
29CAMKK20.97564824
30RPS6KB20.97492955
31MAP3K90.96716430
32SIK30.96070495
33BTK0.91138643
34PASK0.84586624
35TYRO30.83299003
36MARK30.80337961
37CASK0.74664691
38LYN0.72563075
39SIK10.71591683
40MAP3K110.71135760
41TAOK30.69686736
42GRK70.68350274
43PBK0.66917045
44PRKCQ0.64145264
45NME10.62924630
46MAPK130.61503553
47TGFBR10.60243403
48PAK20.59857873
49LCK0.57301882
50KIT0.56621872
51RPS6KA60.55777910
52NTRK30.55092299
53PTK2B0.51312110
54MATK0.50481489
55ADRBK10.50287902
56MARK10.49204422
57PRKCG0.42068568
58MAP2K10.41690281
59PAK60.41084255
60FES0.40435246
61MAP3K130.39040466
62HIPK20.37968363
63TRPM70.36367096
64PLK20.33276595
65HCK0.33076511
66LMTK20.32773833
67RPS6KL10.32645607
68RPS6KC10.32645607
69PHKG10.31714817
70PHKG20.31714817
71DYRK20.29983285
72RPS6KB10.26000557
73CAMK2A0.25916646
74RPS6KA20.25684405
75ZAP700.25165737
76MAPKAPK50.22631639
77PDK10.21796220
78PRKCB0.21385932
79TNK20.20910047
80CHEK20.20679228
81PRKCA0.20652395
82PRKACA0.19739374
83IGF1R0.19076683
84IRAK10.18907646
85PDPK10.18720333
86MAP3K40.18447591
87MUSK0.18392175
88PRKACB0.17386899
89PRKCE0.14934287
90OBSCN0.14837117
91DAPK30.14755667
92CAMKK10.14423616
93FYN0.14024112
94PRKD30.12459844
95EPHA20.11870880
96PRKACG0.11511299
97TXK0.10795995
98INSR0.10495407
99NTRK20.10328471
100CAMK2B0.10283646

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.26882446
2Pancreatic secretion_Homo sapiens_hsa049723.99230449
3Selenocompound metabolism_Homo sapiens_hsa004503.90365967
4Sulfur metabolism_Homo sapiens_hsa009203.32935626
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.31868457
6Fat digestion and absorption_Homo sapiens_hsa049753.14100280
7Linoleic acid metabolism_Homo sapiens_hsa005912.90982081
8Protein digestion and absorption_Homo sapiens_hsa049742.19151343
9Fatty acid biosynthesis_Homo sapiens_hsa000611.95494665
10Ether lipid metabolism_Homo sapiens_hsa005651.85726787
11Ribosome_Homo sapiens_hsa030101.77806418
12Tryptophan metabolism_Homo sapiens_hsa003801.72784630
13Glycerolipid metabolism_Homo sapiens_hsa005611.70687221
14Ovarian steroidogenesis_Homo sapiens_hsa049131.70406437
15Olfactory transduction_Homo sapiens_hsa047401.68975736
16Primary immunodeficiency_Homo sapiens_hsa053401.68604394
17ABC transporters_Homo sapiens_hsa020101.67595660
18Morphine addiction_Homo sapiens_hsa050321.66119839
19Taste transduction_Homo sapiens_hsa047421.64416701
20Arachidonic acid metabolism_Homo sapiens_hsa005901.57813495
21Nicotine addiction_Homo sapiens_hsa050331.54927816
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49736210
23Starch and sucrose metabolism_Homo sapiens_hsa005001.33891344
24Salivary secretion_Homo sapiens_hsa049701.33246810
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.29057303
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.26578532
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24373623
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23640950
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23272871
30Graft-versus-host disease_Homo sapiens_hsa053321.10975106
31Dorso-ventral axis formation_Homo sapiens_hsa043201.10742303
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.09013832
33Calcium signaling pathway_Homo sapiens_hsa040201.04476058
34Gastric acid secretion_Homo sapiens_hsa049711.03792082
35Histidine metabolism_Homo sapiens_hsa003401.03005399
36One carbon pool by folate_Homo sapiens_hsa006701.02453332
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02151885
38Serotonergic synapse_Homo sapiens_hsa047261.01517848
39Asthma_Homo sapiens_hsa053101.01203671
40Glutamatergic synapse_Homo sapiens_hsa047240.97613031
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97338501
42Allograft rejection_Homo sapiens_hsa053300.95939096
43Type I diabetes mellitus_Homo sapiens_hsa049400.95747089
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94652310
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.93487849
46Butanoate metabolism_Homo sapiens_hsa006500.92614891
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90316746
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.88574608
49Circadian entrainment_Homo sapiens_hsa047130.86605940
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85648261
51Homologous recombination_Homo sapiens_hsa034400.85404977
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.83710051
53Autoimmune thyroid disease_Homo sapiens_hsa053200.82973276
54RNA polymerase_Homo sapiens_hsa030200.79584106
55Nitrogen metabolism_Homo sapiens_hsa009100.79420949
56Fatty acid degradation_Homo sapiens_hsa000710.78745974
57Vitamin digestion and absorption_Homo sapiens_hsa049770.78185302
58Retinol metabolism_Homo sapiens_hsa008300.77042046
59Cardiac muscle contraction_Homo sapiens_hsa042600.75234186
60Chemical carcinogenesis_Homo sapiens_hsa052040.72839879
61Hematopoietic cell lineage_Homo sapiens_hsa046400.72754198
62Caffeine metabolism_Homo sapiens_hsa002320.71244598
63Purine metabolism_Homo sapiens_hsa002300.68990312
64Insulin secretion_Homo sapiens_hsa049110.68713731
65GABAergic synapse_Homo sapiens_hsa047270.67408665
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64923424
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.63914551
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61489048
69Oxidative phosphorylation_Homo sapiens_hsa001900.60939527
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60017475
71Regulation of autophagy_Homo sapiens_hsa041400.57796253
72Cholinergic synapse_Homo sapiens_hsa047250.52198235
73Parkinsons disease_Homo sapiens_hsa050120.50905689
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50072505
75Cocaine addiction_Homo sapiens_hsa050300.49309327
76Fatty acid metabolism_Homo sapiens_hsa012120.48696771
77Thyroid hormone synthesis_Homo sapiens_hsa049180.46849832
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46809414
79Steroid biosynthesis_Homo sapiens_hsa001000.46628685
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44946362
81Oxytocin signaling pathway_Homo sapiens_hsa049210.43457071
82Platelet activation_Homo sapiens_hsa046110.42609062
83Bile secretion_Homo sapiens_hsa049760.42353485
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41812256
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39936026
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39638320
87Metabolic pathways_Homo sapiens_hsa011000.38586289
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38246933
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36980113
90Peroxisome_Homo sapiens_hsa041460.36516758
91Amphetamine addiction_Homo sapiens_hsa050310.35255523
92Hedgehog signaling pathway_Homo sapiens_hsa043400.35105242
93Huntingtons disease_Homo sapiens_hsa050160.34888246
94Antigen processing and presentation_Homo sapiens_hsa046120.33880455
95African trypanosomiasis_Homo sapiens_hsa051430.32928657
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32722853
97Renin secretion_Homo sapiens_hsa049240.31601532
98Ras signaling pathway_Homo sapiens_hsa040140.30719188
99Rheumatoid arthritis_Homo sapiens_hsa053230.29999670
100cAMP signaling pathway_Homo sapiens_hsa040240.27745162

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