REXO1L1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine catabolic process (GO:0046218)5.12586288
2tryptophan catabolic process (GO:0006569)5.12586288
3indole-containing compound catabolic process (GO:0042436)5.12586288
4kynurenine metabolic process (GO:0070189)4.99047258
5indolalkylamine metabolic process (GO:0006586)4.78493225
6behavioral response to nicotine (GO:0035095)4.73038984
7cilium or flagellum-dependent cell motility (GO:0001539)4.42534065
8signal peptide processing (GO:0006465)4.38185309
9tryptophan metabolic process (GO:0006568)4.32797411
10detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.25172507
11L-fucose catabolic process (GO:0042355)4.07864159
12fucose catabolic process (GO:0019317)4.07864159
13L-fucose metabolic process (GO:0042354)4.07864159
14detection of light stimulus involved in sensory perception (GO:0050962)4.05362149
15detection of light stimulus involved in visual perception (GO:0050908)4.05362149
16indole-containing compound metabolic process (GO:0042430)3.72270094
17regulation of hippo signaling (GO:0035330)3.71416727
18protein K48-linked deubiquitination (GO:0071108)3.68526996
19establishment of protein localization to Golgi (GO:0072600)3.68132279
20neural tube formation (GO:0001841)3.68031450
21positive regulation of developmental pigmentation (GO:0048087)3.66523696
22regulation of pigment cell differentiation (GO:0050932)3.64837739
23reflex (GO:0060004)3.56708470
24photoreceptor cell maintenance (GO:0045494)3.54251029
25regulation of posttranscriptional gene silencing (GO:0060147)3.52227239
26regulation of gene silencing by miRNA (GO:0060964)3.52227239
27regulation of gene silencing by RNA (GO:0060966)3.52227239
28serotonin metabolic process (GO:0042428)3.44052012
29gamma-aminobutyric acid transport (GO:0015812)3.42339942
30negative regulation of protein localization to cell surface (GO:2000009)3.38271085
31oxidative demethylation (GO:0070989)3.36915179
32monoubiquitinated protein deubiquitination (GO:0035520)3.36324609
33cellular ketone body metabolic process (GO:0046950)3.34692208
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33417438
35tachykinin receptor signaling pathway (GO:0007217)3.32713054
36behavioral response to ethanol (GO:0048149)3.29306741
37snRNA transcription (GO:0009301)3.27391020
38thyroid hormone metabolic process (GO:0042403)3.27009009
39NAD biosynthetic process (GO:0009435)3.26930883
40sulfation (GO:0051923)3.24146584
41primary amino compound metabolic process (GO:1901160)3.23555769
42amine catabolic process (GO:0009310)3.18166101
43cellular biogenic amine catabolic process (GO:0042402)3.18166101
44neuronal action potential (GO:0019228)3.17932977
45protein K63-linked deubiquitination (GO:0070536)3.17084693
46regulation of sarcomere organization (GO:0060297)3.16545672
47response to pheromone (GO:0019236)3.16222832
48protein K11-linked deubiquitination (GO:0035871)3.05492274
49benzene-containing compound metabolic process (GO:0042537)3.04835863
50regulation of translation, ncRNA-mediated (GO:0045974)3.04416691
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04416691
52negative regulation of translation, ncRNA-mediated (GO:0040033)3.04416691
53flavonoid metabolic process (GO:0009812)3.04024865
54detection of mechanical stimulus involved in sensory perception (GO:0050974)3.03316707
55membrane depolarization during action potential (GO:0086010)3.01328810
56regulation of establishment of cell polarity (GO:2000114)2.99058908
57negative regulation of mast cell activation (GO:0033004)2.98081378
58negative regulation of sodium ion transport (GO:0010766)2.98061254
59ketone body metabolic process (GO:1902224)2.97025226
60cilium movement (GO:0003341)2.96733323
61endosome to melanosome transport (GO:0035646)2.95350235
62endosome to pigment granule transport (GO:0043485)2.95350235
63axoneme assembly (GO:0035082)2.92824807
64negative regulation of systemic arterial blood pressure (GO:0003085)2.92223177
65interkinetic nuclear migration (GO:0022027)2.91815684
66epithelial cilium movement (GO:0003351)2.90065656
67protein localization to cilium (GO:0061512)2.86088797
68auditory receptor cell stereocilium organization (GO:0060088)2.85357185
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78832269
70retinal cone cell development (GO:0046549)2.77694429
71cilium organization (GO:0044782)2.77248084
72negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75954154
73regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74675650
74nonmotile primary cilium assembly (GO:0035058)2.73155471
75cilium morphogenesis (GO:0060271)2.72486275
76cilium assembly (GO:0042384)2.70756364
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69841529
78cellular response to sterol (GO:0036315)2.67346717
79protein polyglutamylation (GO:0018095)2.66819193
80aromatic amino acid family catabolic process (GO:0009074)2.66609406
81regulation of establishment or maintenance of cell polarity (GO:0032878)2.66215987
82neuronal action potential propagation (GO:0019227)2.66182127
83multicellular organism reproduction (GO:0032504)2.61300087
84piRNA metabolic process (GO:0034587)2.59497422
85drug catabolic process (GO:0042737)2.59345732
86startle response (GO:0001964)2.57833547
87regulation of action potential (GO:0098900)2.57475015
88inner ear receptor stereocilium organization (GO:0060122)2.57132346
89lipid translocation (GO:0034204)2.57062894
90phospholipid translocation (GO:0045332)2.57062894
91transmission of nerve impulse (GO:0019226)2.55051796
92appendage development (GO:0048736)2.52900208
93limb development (GO:0060173)2.52900208
94aromatic amino acid family metabolic process (GO:0009072)2.49149503
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48183594
96proline transport (GO:0015824)2.47472728
97cardiovascular system development (GO:0072358)2.46297092
98righting reflex (GO:0060013)2.43413301
99positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.41766269
100phosphatidylinositol acyl-chain remodeling (GO:0036149)2.41162324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.17277715
2GBX2_23144817_ChIP-Seq_PC3_Human3.56366925
3VDR_22108803_ChIP-Seq_LS180_Human3.31983999
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.00599278
5ZNF274_21170338_ChIP-Seq_K562_Hela2.99445007
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94258725
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69287316
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49059678
9IGF1R_20145208_ChIP-Seq_DFB_Human2.42808990
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36655465
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24108367
12TAF15_26573619_Chip-Seq_HEK293_Human2.21589897
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.10748028
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08225059
15P300_19829295_ChIP-Seq_ESCs_Human2.07996887
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01927539
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99134705
18ER_23166858_ChIP-Seq_MCF-7_Human1.89998241
19STAT3_23295773_ChIP-Seq_U87_Human1.89572992
20EWS_26573619_Chip-Seq_HEK293_Human1.88872199
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84341750
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.84223451
23FUS_26573619_Chip-Seq_HEK293_Human1.82313978
24SMAD4_21799915_ChIP-Seq_A2780_Human1.81867105
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78293937
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73301607
27BCAT_22108803_ChIP-Seq_LS180_Human1.70248724
28TCF4_23295773_ChIP-Seq_U87_Human1.70191064
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70133932
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.67004143
31AR_25329375_ChIP-Seq_VCAP_Human1.60530107
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58385366
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53766617
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53766617
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53292084
36CBP_20019798_ChIP-Seq_JUKART_Human1.53292084
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50265638
38DROSHA_22980978_ChIP-Seq_HELA_Human1.49121429
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.47363532
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.47100857
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46786420
42AR_21572438_ChIP-Seq_LNCaP_Human1.46714991
43REST_21632747_ChIP-Seq_MESCs_Mouse1.45364351
44PRDM14_20953172_ChIP-Seq_ESCs_Human1.44338263
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44012235
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42235106
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41329591
48TCF4_22108803_ChIP-Seq_LS180_Human1.40580343
49TP53_16413492_ChIP-PET_HCT116_Human1.39636067
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39112108
51RUNX2_22187159_ChIP-Seq_PCA_Human1.37138576
52IRF1_19129219_ChIP-ChIP_H3396_Human1.36797222
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35189389
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33964828
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32424024
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31767570
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.31681728
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.31448273
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28232450
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26320064
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24549727
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24467965
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.23004390
64TP53_22573176_ChIP-Seq_HFKS_Human1.22890226
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.21969931
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20852985
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20599715
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.19272642
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18325202
70RNF2_27304074_Chip-Seq_NSC_Mouse1.17239900
71SOX2_19829295_ChIP-Seq_ESCs_Human1.15932693
72NANOG_19829295_ChIP-Seq_ESCs_Human1.15932693
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.14985552
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14429305
75KDM2B_26808549_Chip-Seq_REH_Human1.12619367
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11924252
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11721364
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.11719532
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11482595
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.11332280
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11102368
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08611683
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07182147
84AHR_22903824_ChIP-Seq_MCF-7_Human1.06929031
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06304665
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.06304665
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05556090
88P53_22387025_ChIP-Seq_ESCs_Mouse1.05190486
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04531257
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.04509215
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04489190
92CDX2_22108803_ChIP-Seq_LS180_Human1.02751796
93RXR_22108803_ChIP-Seq_LS180_Human1.02227626
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00928778
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.99774002
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.99088225
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98757704
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97108329
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96727409
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.96715495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.69649623
2MP0000569_abnormal_digit_pigmentation3.57496185
3MP0003646_muscle_fatigue2.76777470
4MP0004043_abnormal_pH_regulation2.69939378
5MP0001968_abnormal_touch/_nociception2.66324723
6MP0005551_abnormal_eye_electrophysiolog2.60571399
7MP0009046_muscle_twitch2.51940218
8MP0008877_abnormal_DNA_methylation2.43523431
9MP0001501_abnormal_sleep_pattern2.43254803
10MP0002736_abnormal_nociception_after2.25909450
11MP0003787_abnormal_imprinting2.20411765
12MP0000427_abnormal_hair_cycle2.19767629
13MP0009745_abnormal_behavioral_response2.16009237
14MP0008057_abnormal_DNA_replication2.03492745
15MP0006276_abnormal_autonomic_nervous1.94534180
16MP0006292_abnormal_olfactory_placode1.92689340
17MP0002102_abnormal_ear_morphology1.92634909
18MP0004142_abnormal_muscle_tone1.91065118
19MP0001485_abnormal_pinna_reflex1.87020503
20MP0002272_abnormal_nervous_system1.81796245
21MP0008872_abnormal_physiological_respon1.79101086
22MP0005645_abnormal_hypothalamus_physiol1.76758958
23MP0005646_abnormal_pituitary_gland1.72682283
24MP0001486_abnormal_startle_reflex1.70687725
25MP0002735_abnormal_chemical_nociception1.67541916
26MP0001986_abnormal_taste_sensitivity1.59292032
27MP0003880_abnormal_central_pattern1.58400575
28MP0002572_abnormal_emotion/affect_behav1.55367625
29MP0002876_abnormal_thyroid_physiology1.53629795
30MP0005253_abnormal_eye_physiology1.53272050
31MP0004145_abnormal_muscle_electrophysio1.48695760
32MP0002837_dystrophic_cardiac_calcinosis1.48108953
33MP0002067_abnormal_sensory_capabilities1.47593548
34MP0002064_seizures1.46966990
35MP0002733_abnormal_thermal_nociception1.46219389
36MP0001970_abnormal_pain_threshold1.45756632
37MP0006072_abnormal_retinal_apoptosis1.44345335
38MP0005377_hearing/vestibular/ear_phenot1.43476973
39MP0003878_abnormal_ear_physiology1.43476973
40MP0003635_abnormal_synaptic_transmissio1.43305642
41MP0004742_abnormal_vestibular_system1.41422574
42MP0002557_abnormal_social/conspecific_i1.41377530
43MP0003136_yellow_coat_color1.40982443
44MP0004924_abnormal_behavior1.40326350
45MP0005386_behavior/neurological_phenoty1.40326350
46MP0000631_abnormal_neuroendocrine_gland1.38371419
47MP0005174_abnormal_tail_pigmentation1.33752647
48MP0004885_abnormal_endolymph1.30951909
49MP0004147_increased_porphyrin_level1.27126388
50MP0010386_abnormal_urinary_bladder1.26219930
51MP0002138_abnormal_hepatobiliary_system1.25251453
52MP0000383_abnormal_hair_follicle1.20041525
53MP0002063_abnormal_learning/memory/cond1.18245150
54MP0000372_irregular_coat_pigmentation1.12987132
55MP0002938_white_spotting1.11123525
56MP0001440_abnormal_grooming_behavior1.09841743
57MP0002734_abnormal_mechanical_nocicepti1.09612470
58MP0008961_abnormal_basal_metabolism1.08198295
59MP0000230_abnormal_systemic_arterial1.07851160
60MP0002229_neurodegeneration1.05870782
61MP0001984_abnormal_olfaction1.04906830
62MP0003890_abnormal_embryonic-extraembry1.03026821
63MP0002184_abnormal_innervation1.02240899
64MP0004133_heterotaxia1.01416834
65MP0005195_abnormal_posterior_eye1.01078392
66MP0002653_abnormal_ependyma_morphology0.99545029
67MP0002928_abnormal_bile_duct0.99453506
68MP0005410_abnormal_fertilization0.98872063
69MP0005423_abnormal_somatic_nervous0.98610036
70MP0003879_abnormal_hair_cell0.97342969
71MP0002752_abnormal_somatic_nervous0.96182941
72MP0003950_abnormal_plasma_membrane0.96145966
73MP0008875_abnormal_xenobiotic_pharmacok0.95215576
74MP0000538_abnormal_urinary_bladder0.94103142
75MP0003119_abnormal_digestive_system0.93422236
76MP0002234_abnormal_pharynx_morphology0.93412136
77MP0000778_abnormal_nervous_system0.93255766
78MP0005389_reproductive_system_phenotype0.92475053
79MP0004130_abnormal_muscle_cell0.91794365
80MP0002638_abnormal_pupillary_reflex0.91139441
81MP0003633_abnormal_nervous_system0.89510125
82MP0003698_abnormal_male_reproductive0.89357218
83MP0000955_abnormal_spinal_cord0.88431997
84MP0003121_genomic_imprinting0.88427243
85MP0002882_abnormal_neuron_morphology0.86679258
86MP0001963_abnormal_hearing_physiology0.86197312
87MP0000026_abnormal_inner_ear0.85811383
88MP0002160_abnormal_reproductive_system0.85074763
89MP0002095_abnormal_skin_pigmentation0.84977840
90MP0002163_abnormal_gland_morphology0.84702662
91MP0005266_abnormal_metabolism0.84675906
92MP0003045_fibrosis0.83968196
93MP0005310_abnormal_salivary_gland0.83471459
94MP0004215_abnormal_myocardial_fiber0.81305546
95MP0001664_abnormal_digestion0.79635180
96MP0003137_abnormal_impulse_conducting0.79078594
97MP0005670_abnormal_white_adipose0.79061303
98MP0003718_maternal_effect0.78426581
99MP0002693_abnormal_pancreas_physiology0.77936409
100MP0004085_abnormal_heartbeat0.77911558

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.95331440
2Pancreatic fibrosis (HP:0100732)4.53802121
3Hyperventilation (HP:0002883)4.32467100
4True hermaphroditism (HP:0010459)4.26454321
5Genetic anticipation (HP:0003743)4.16947039
6Abnormality of midbrain morphology (HP:0002418)3.85083023
7Molar tooth sign on MRI (HP:0002419)3.85083023
8Congenital stationary night blindness (HP:0007642)3.81145607
9Gaze-evoked nystagmus (HP:0000640)3.73512183
10Progressive cerebellar ataxia (HP:0002073)3.66804492
11Abnormality of the renal cortex (HP:0011035)3.59223417
12Aplasia/Hypoplasia of the tibia (HP:0005772)3.54768674
13Nephronophthisis (HP:0000090)3.54534057
14Protruding tongue (HP:0010808)3.50161407
15Medial flaring of the eyebrow (HP:0010747)3.45261054
16Attenuation of retinal blood vessels (HP:0007843)3.39821327
17Cystic liver disease (HP:0006706)3.35815316
18Abnormality of the renal medulla (HP:0100957)3.29682708
19Abolished electroretinogram (ERG) (HP:0000550)3.07708317
20Clumsiness (HP:0002312)3.04331871
21Gait imbalance (HP:0002141)2.96032683
22Congenital sensorineural hearing impairment (HP:0008527)2.92330172
23Bony spicule pigmentary retinopathy (HP:0007737)2.86758155
24Congenital primary aphakia (HP:0007707)2.85073610
25Chronic hepatic failure (HP:0100626)2.83807422
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.82762063
27Febrile seizures (HP:0002373)2.79621694
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69862660
29Abnormality of alanine metabolism (HP:0010916)2.69862660
30Hyperalaninemia (HP:0003348)2.69862660
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.67692732
32Fair hair (HP:0002286)2.67638679
33Sclerocornea (HP:0000647)2.67521314
34Nephrogenic diabetes insipidus (HP:0009806)2.63671522
35Inability to walk (HP:0002540)2.60730832
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.57947211
37Type II lissencephaly (HP:0007260)2.57247028
38Broad-based gait (HP:0002136)2.57065075
39Tubular atrophy (HP:0000092)2.55771670
40Absent speech (HP:0001344)2.52343932
41Congenital hepatic fibrosis (HP:0002612)2.46222498
42Renal cortical cysts (HP:0000803)2.44779894
43Genital tract atresia (HP:0001827)2.44041371
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.42763867
45Absent/shortened dynein arms (HP:0200106)2.42763867
46Abnormal drinking behavior (HP:0030082)2.40311581
47Polydipsia (HP:0001959)2.40311581
48Abnormal rod and cone electroretinograms (HP:0008323)2.37440723
49Decreased circulating renin level (HP:0003351)2.35043372
50Focal seizures (HP:0007359)2.33196029
51Furrowed tongue (HP:0000221)2.32178220
52Keratoconus (HP:0000563)2.32145283
53Increased corneal curvature (HP:0100692)2.32145283
54Vaginal atresia (HP:0000148)2.30333992
55Poor coordination (HP:0002370)2.25244981
56Central scotoma (HP:0000603)2.21070252
57Anencephaly (HP:0002323)2.20223454
58Progressive inability to walk (HP:0002505)2.19318455
59Patellar aplasia (HP:0006443)2.16797873
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15442495
61Abnormal ciliary motility (HP:0012262)2.14822028
62Decreased central vision (HP:0007663)2.12954033
63Postaxial foot polydactyly (HP:0001830)2.12436207
64Stomach cancer (HP:0012126)2.11731074
65Focal motor seizures (HP:0011153)2.11508224
66Male pseudohermaphroditism (HP:0000037)2.10042687
67Generalized hypopigmentation of hair (HP:0011358)2.06063733
68Congenital, generalized hypertrichosis (HP:0004540)2.05328385
69Dialeptic seizures (HP:0011146)2.04467389
70Aplasia/Hypoplasia of the patella (HP:0006498)2.00616200
71Cerebellar dysplasia (HP:0007033)1.99898257
72Lissencephaly (HP:0001339)1.98737664
73Pendular nystagmus (HP:0012043)1.98142484
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95962965
75Preaxial hand polydactyly (HP:0001177)1.95356544
76Constricted visual fields (HP:0001133)1.94932025
77Widely spaced teeth (HP:0000687)1.93737485
78Retinitis pigmentosa (HP:0000510)1.93433238
79Drooling (HP:0002307)1.93336017
80Abnormal respiratory epithelium morphology (HP:0012253)1.92886785
81Abnormal respiratory motile cilium morphology (HP:0005938)1.92886785
82Short foot (HP:0001773)1.90821397
83Small hand (HP:0200055)1.89196968
84Hypothermia (HP:0002045)1.84945079
85Polyuria (HP:0000103)1.84841902
86Bile duct proliferation (HP:0001408)1.84256379
87Abnormal biliary tract physiology (HP:0012439)1.84256379
88Large for gestational age (HP:0001520)1.78763256
89Preaxial foot polydactyly (HP:0001841)1.77076279
90Oligodactyly (hands) (HP:0001180)1.76671753
91Increased cerebral lipofuscin (HP:0011813)1.75615536
92Abnormality of macular pigmentation (HP:0008002)1.74467105
93Severe muscular hypotonia (HP:0006829)1.74354451
94Hypoplastic ischia (HP:0003175)1.72880803
95Excessive salivation (HP:0003781)1.72071964
96Hemiparesis (HP:0001269)1.70123269
97Absence seizures (HP:0002121)1.70087636
98Abnormal respiratory motile cilium physiology (HP:0012261)1.69309484
99Astigmatism (HP:0000483)1.68637603
100Chorioretinal atrophy (HP:0000533)1.67892614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.60884507
2BMPR1B3.02551044
3ACVR1B2.98078119
4ADRBK22.76669421
5CASK2.57523454
6TAOK32.21390781
7ZAK2.06770601
8INSRR2.03788650
9NUAK11.98414387
10WNK31.94392657
11GRK11.93979167
12MAPK131.88816878
13WNK41.86806080
14MAP4K21.72191670
15NTRK31.69666568
16TNIK1.63385233
17OXSR11.57025353
18MKNK21.49324048
19MAP3K41.47523247
20ADRBK11.37698031
21DAPK21.30088139
22STK391.30053042
23PINK11.27437517
24TXK1.23367694
25TLK11.19897021
26TEC1.04196435
27AKT31.03542581
28PIK3CG1.01620775
29MARK11.00124793
30STK38L0.98221378
31STK30.94423774
32PRKCE0.94163408
33PRKCG0.93761993
34PAK30.93028980
35TGFBR10.92372041
36PIK3CA0.91864042
37CAMKK20.84469507
38PTK2B0.82189518
39CDK190.80299186
40PNCK0.78973844
41SGK20.67674424
42PLK40.66616868
43MAP2K70.66431842
44TIE10.66167322
45PKN10.64489372
46TRPM70.63930137
47EPHA40.63806872
48NLK0.63331667
49CHUK0.59806596
50CAMK1G0.59802776
51CAMK2A0.58808082
52TNK20.57177839
53PLK20.57084274
54NTRK20.55669500
55NEK20.54861136
56CAMK1D0.53279353
57IKBKB0.52181696
58ITK0.52042138
59TRIM280.51650930
60CAMK10.51437965
61IRAK10.51415232
62DYRK20.50755289
63SIK20.50572134
64PRKAA20.50549884
65WNK10.48650183
66CSNK1G20.46416227
67FER0.45969148
68MKNK10.45903299
69ERBB20.43801176
70STK110.43726149
71PRKACA0.42402329
72CSNK1G10.41680591
73CAMK40.41517097
74MAP2K60.41277970
75CSNK1D0.40960107
76GRK70.40506304
77MUSK0.39944380
78PRKCQ0.39918543
79MAP3K70.39517598
80MAPKAPK30.38292994
81KIT0.37777602
82SGK2230.37612589
83SGK4940.37612589
84PRKAA10.36469548
85BRSK20.36198489
86PRKG10.36045463
87CDK30.34967894
88PHKG10.34866769
89PHKG20.34866769
90CHEK20.34311781
91MAPKAPK50.34222876
92SGK10.33065770
93CSNK1A1L0.32600792
94MARK30.32009210
95CSNK1A10.31456888
96PRKCA0.30420965
97PRKACB0.30224350
98OBSCN0.27283816
99GRK50.26722967
100IGF1R0.25720479

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.88108109
2Phototransduction_Homo sapiens_hsa047442.73886098
3Linoleic acid metabolism_Homo sapiens_hsa005912.59911831
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51942129
5Butanoate metabolism_Homo sapiens_hsa006502.47494506
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35350984
7Nitrogen metabolism_Homo sapiens_hsa009102.30469532
8Tryptophan metabolism_Homo sapiens_hsa003802.23195498
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.13885104
10ABC transporters_Homo sapiens_hsa020102.04593142
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99397484
12Morphine addiction_Homo sapiens_hsa050321.85762068
13Taste transduction_Homo sapiens_hsa047421.78121289
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74566776
15Ether lipid metabolism_Homo sapiens_hsa005651.73558903
16Homologous recombination_Homo sapiens_hsa034401.70669383
17Circadian entrainment_Homo sapiens_hsa047131.68140064
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67581603
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66078700
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.62224693
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59910710
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55678346
23Glutamatergic synapse_Homo sapiens_hsa047241.55341845
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.52805224
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.50633798
26Olfactory transduction_Homo sapiens_hsa047401.49757064
27GABAergic synapse_Homo sapiens_hsa047271.49523887
28Serotonergic synapse_Homo sapiens_hsa047261.48278474
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43359176
30Insulin secretion_Homo sapiens_hsa049111.39165244
31Selenocompound metabolism_Homo sapiens_hsa004501.35712140
32Retinol metabolism_Homo sapiens_hsa008301.35275816
33Chemical carcinogenesis_Homo sapiens_hsa052041.34187700
34Salivary secretion_Homo sapiens_hsa049701.34057962
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30167141
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.29816507
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29098006
38Ovarian steroidogenesis_Homo sapiens_hsa049131.26979804
39Fanconi anemia pathway_Homo sapiens_hsa034601.25680730
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24527420
41Glycerolipid metabolism_Homo sapiens_hsa005611.21642151
42Calcium signaling pathway_Homo sapiens_hsa040201.20408853
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11255509
44Caffeine metabolism_Homo sapiens_hsa002321.08725936
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02899088
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.02296925
47Asthma_Homo sapiens_hsa053101.02221599
48Arachidonic acid metabolism_Homo sapiens_hsa005901.00910595
49Dorso-ventral axis formation_Homo sapiens_hsa043200.99445563
50Histidine metabolism_Homo sapiens_hsa003400.99366613
51Basal transcription factors_Homo sapiens_hsa030220.96927241
52Propanoate metabolism_Homo sapiens_hsa006400.92960431
53Dopaminergic synapse_Homo sapiens_hsa047280.90403570
54Cholinergic synapse_Homo sapiens_hsa047250.90369754
55Pancreatic secretion_Homo sapiens_hsa049720.89116611
56Graft-versus-host disease_Homo sapiens_hsa053320.87677018
57Long-term depression_Homo sapiens_hsa047300.87338288
58beta-Alanine metabolism_Homo sapiens_hsa004100.85529986
59Gastric acid secretion_Homo sapiens_hsa049710.83115211
60Oxytocin signaling pathway_Homo sapiens_hsa049210.81377963
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79921253
62Regulation of autophagy_Homo sapiens_hsa041400.73587915
63cAMP signaling pathway_Homo sapiens_hsa040240.71795418
64Fat digestion and absorption_Homo sapiens_hsa049750.68618887
65Renin secretion_Homo sapiens_hsa049240.66235596
66Peroxisome_Homo sapiens_hsa041460.65923497
67Fatty acid biosynthesis_Homo sapiens_hsa000610.65397777
68Cocaine addiction_Homo sapiens_hsa050300.65010193
69Lysine degradation_Homo sapiens_hsa003100.64937584
70Amphetamine addiction_Homo sapiens_hsa050310.63846950
71RNA polymerase_Homo sapiens_hsa030200.63788095
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62296589
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59801600
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58399858
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.53144561
76Type I diabetes mellitus_Homo sapiens_hsa049400.53060290
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49794340
78Bile secretion_Homo sapiens_hsa049760.47058325
79Fatty acid degradation_Homo sapiens_hsa000710.46243540
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45909606
81Circadian rhythm_Homo sapiens_hsa047100.43594075
82RNA degradation_Homo sapiens_hsa030180.42306030
83One carbon pool by folate_Homo sapiens_hsa006700.42188294
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42053781
85Autoimmune thyroid disease_Homo sapiens_hsa053200.41925942
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41460685
87Sphingolipid metabolism_Homo sapiens_hsa006000.41138990
88Protein export_Homo sapiens_hsa030600.40519742
89Allograft rejection_Homo sapiens_hsa053300.40318744
90Cardiac muscle contraction_Homo sapiens_hsa042600.40040348
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38308618
92Type II diabetes mellitus_Homo sapiens_hsa049300.36485550
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.34903685
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34717056
95Ras signaling pathway_Homo sapiens_hsa040140.33520569
96Purine metabolism_Homo sapiens_hsa002300.32013261
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30206334
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30037016
99Mineral absorption_Homo sapiens_hsa049780.29081458
100Huntingtons disease_Homo sapiens_hsa050160.26093038

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