RESP18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein refolding (GO:0042026)8.90478054
2chaperone mediated protein folding requiring cofactor (GO:0051085)8.78883968
3regulation of inclusion body assembly (GO:0090083)6.33773321
4G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.26563482
5spermatid nucleus differentiation (GO:0007289)5.27781686
6COPI coating of Golgi vesicle (GO:0048205)5.16457993
7Golgi transport vesicle coating (GO:0048200)5.16457993
8epithelial cilium movement (GO:0003351)4.89167033
9protein insertion into membrane (GO:0051205)4.88582861
10peptide hormone processing (GO:0016486)4.71542600
11negative regulation of striated muscle cell apoptotic process (GO:0010664)4.68827673
12detection of calcium ion (GO:0005513)4.55958749
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.50565453
14sperm motility (GO:0030317)4.49776855
15positive regulation of amino acid transport (GO:0051957)4.48549571
16centriole replication (GO:0007099)4.24024659
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22293109
18purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.11845203
19regulation of meiosis I (GO:0060631)4.03732520
20dopaminergic neuron differentiation (GO:0071542)4.01684196
21endocrine pancreas development (GO:0031018)4.00295063
22acrosome reaction (GO:0007340)3.92463969
23insulin secretion (GO:0030073)3.91869989
24ER overload response (GO:0006983)3.88570345
25cilium movement (GO:0003341)3.83221417
26protein localization to synapse (GO:0035418)3.82171137
27protein maturation by protein folding (GO:0022417)3.80550584
28protein targeting to Golgi (GO:0000042)3.77285813
29microtubule polymerization or depolymerization (GO:0031109)3.68372152
30regulation of glucocorticoid secretion (GO:2000849)3.64136191
31toxin metabolic process (GO:0009404)3.61927983
32positive regulation of insulin secretion (GO:0032024)3.61388291
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60208860
34regulation of transmission of nerve impulse (GO:0051969)3.57884695
35peripheral nervous system axon ensheathment (GO:0032292)3.54906959
36myelination in peripheral nervous system (GO:0022011)3.54906959
37establishment of protein localization to Golgi (GO:0072600)3.54017245
38regulation of insulin secretion (GO:0050796)3.53772338
39positive regulation of amine transport (GO:0051954)3.51566058
40signal peptide processing (GO:0006465)3.51112112
41retrograde transport, vesicle recycling within Golgi (GO:0000301)3.50980799
42single strand break repair (GO:0000012)3.50176613
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.46261894
44ATP synthesis coupled proton transport (GO:0015986)3.46009875
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.46009875
46spinal cord development (GO:0021510)3.45111921
47ATP hydrolysis coupled proton transport (GO:0015991)3.43332218
48energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.43332218
49microtubule depolymerization (GO:0007019)3.40352705
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.40111378
51NADH dehydrogenase complex assembly (GO:0010257)3.40111378
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40111378
53respiratory electron transport chain (GO:0022904)3.39254741
54positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.35078277
55electron transport chain (GO:0022900)3.34913248
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33436381
57axoneme assembly (GO:0035082)3.31838952
58regulation of peptide hormone secretion (GO:0090276)3.30661516
59detection of temperature stimulus (GO:0016048)3.29001735
60glutamate receptor signaling pathway (GO:0007215)3.28803420
61female mating behavior (GO:0060180)3.28462907
62peptide hormone secretion (GO:0030072)3.25815510
63regulation of peptide secretion (GO:0002791)3.25731076
64protein polyglutamylation (GO:0018095)3.25690525
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25291085
66eating behavior (GO:0042755)3.23400288
67neuron cell-cell adhesion (GO:0007158)3.23016805
682-deoxyribonucleotide biosynthetic process (GO:0009265)3.22869422
69deoxyribose phosphate biosynthetic process (GO:0046385)3.22869422
70limb bud formation (GO:0060174)3.22174106
71regulation of synaptic vesicle exocytosis (GO:2000300)3.21219548
72calcium ion-dependent exocytosis (GO:0017156)3.20955984
73regulation of short-term neuronal synaptic plasticity (GO:0048172)3.20408562
74cGMP biosynthetic process (GO:0006182)3.18494303
75behavioral response to nicotine (GO:0035095)3.17613438
76arachidonic acid secretion (GO:0050482)3.17169654
77icosanoid secretion (GO:0032309)3.17169654
78centriole assembly (GO:0098534)3.16887257
79peptide secretion (GO:0002790)3.14699564
80positive regulation of peptide hormone secretion (GO:0090277)3.12484586
81regulation of striated muscle cell apoptotic process (GO:0010662)3.11982685
82regulation of protein kinase A signaling (GO:0010738)3.11945366
83regulation of vesicle fusion (GO:0031338)3.11118787
84phosphatidylethanolamine metabolic process (GO:0046337)3.10500319
85COPII vesicle coating (GO:0048208)3.09796644
86synaptic vesicle exocytosis (GO:0016079)3.08692546
87regulation of corticosteroid hormone secretion (GO:2000846)3.08665836
88sperm-egg recognition (GO:0035036)3.07484118
89activation of protein kinase A activity (GO:0034199)3.07346076
90cellular response to glucagon stimulus (GO:0071377)3.06946003
91type B pancreatic cell development (GO:0003323)3.06767977
92secondary metabolite biosynthetic process (GO:0044550)3.06111772
93positive regulation of peptide secretion (GO:0002793)3.05619208
94response to pheromone (GO:0019236)3.05342027
95cerebellar Purkinje cell layer development (GO:0021680)3.05045854
96regulation of penile erection (GO:0060405)3.04828383
97regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04737203
98maternal behavior (GO:0042711)3.04079260
99lateral ventricle development (GO:0021670)3.03722848
100glandular epithelial cell differentiation (GO:0002067)3.03288907
101glomerular visceral epithelial cell development (GO:0072015)3.03204490
102regulation of hormone secretion (GO:0046883)3.02864923
103cellular ketone body metabolic process (GO:0046950)3.02809853
104retinal cone cell development (GO:0046549)3.01498934
105cGMP metabolic process (GO:0046068)3.01475781
106regulation of calcium ion-dependent exocytosis (GO:0017158)3.01270878
107neuropeptide signaling pathway (GO:0007218)2.99171821
108cerebral cortex neuron differentiation (GO:0021895)2.98108916
109regulation of type B pancreatic cell apoptotic process (GO:2000674)2.97006411
110fusion of sperm to egg plasma membrane (GO:0007342)2.95882591
111binding of sperm to zona pellucida (GO:0007339)2.95800577
112positive regulation of catecholamine secretion (GO:0033605)2.95315787
113sulfation (GO:0051923)2.95023914
114regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.93672685
115spermatogenesis (GO:0007283)2.93453242
116intra-Golgi vesicle-mediated transport (GO:0006891)2.93296837
117negative regulation of JUN kinase activity (GO:0043508)2.92762761
118male gamete generation (GO:0048232)2.91216094
119sequestering of actin monomers (GO:0042989)2.90695380
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.90070628
121positive regulation of ATPase activity (GO:0032781)2.88802459
122positive regulation of ATP catabolic process (GO:1903291)2.88802459
123positive regulation of growth hormone secretion (GO:0060124)2.88343026
124type B pancreatic cell proliferation (GO:0044342)2.87851644
125transferrin transport (GO:0033572)2.87620417
126regulation of uterine smooth muscle contraction (GO:0070472)2.87555596
127feeding behavior (GO:0007631)2.87161662
128locomotory exploration behavior (GO:0035641)2.86971506
129dentate gyrus development (GO:0021542)2.86590334
130regulation of norepinephrine secretion (GO:0014061)2.86007094
131neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.85560866
132adult feeding behavior (GO:0008343)2.85124843
133midbrain development (GO:0030901)2.84548737
134intraciliary transport (GO:0042073)2.82778954
135multicellular organism reproduction (GO:0032504)2.82448174
136maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81675573
137regulation of synaptic vesicle transport (GO:1902803)2.81416724
138regulation of voltage-gated calcium channel activity (GO:1901385)2.80847392
139neuromuscular process controlling posture (GO:0050884)2.80781467
140growth hormone secretion (GO:0030252)2.80687158
141microtubule severing (GO:0051013)2.79956889
142ribonucleoprotein complex disassembly (GO:0032988)2.79776883
143positive regulation of meiosis (GO:0045836)2.79757131
144presynaptic membrane assembly (GO:0097105)2.79629262
145negative regulation of catecholamine secretion (GO:0033604)2.79247248
146presynaptic membrane organization (GO:0097090)2.78859096
147acrosome assembly (GO:0001675)2.78297162
148protein localization to cilium (GO:0061512)2.78204616
149glomerular epithelial cell development (GO:0072310)2.77937992
150suckling behavior (GO:0001967)2.77508782
151neurotransmitter secretion (GO:0007269)2.76493250
152neurotransmitter catabolic process (GO:0042135)2.75776562
153dopamine biosynthetic process (GO:0042416)2.75279261
154deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.75174664
155synaptic vesicle docking involved in exocytosis (GO:0016081)2.74496662
156ferric iron transport (GO:0015682)2.74476836
157trivalent inorganic cation transport (GO:0072512)2.74476836
158vesicle coating (GO:0006901)2.73627442
159mannosylation (GO:0097502)2.72877243
160regulation of rhodopsin mediated signaling pathway (GO:0022400)2.72509380
161positive regulation of dendritic spine development (GO:0060999)2.69826721
162regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.69046658
163inner mitochondrial membrane organization (GO:0007007)2.68744601
164response to dietary excess (GO:0002021)2.68603140
165ketone body metabolic process (GO:1902224)2.68238615
166protein localization to Golgi apparatus (GO:0034067)2.67584453
167parental behavior (GO:0060746)2.67455495
168catecholamine transport (GO:0051937)2.67424530
169gamete generation (GO:0007276)2.66627948
170positive regulation of vesicle fusion (GO:0031340)2.66621251
171signal release (GO:0023061)2.66320425
172gamma-aminobutyric acid signaling pathway (GO:0007214)2.66246705
173positive regulation of hormone secretion (GO:0046887)2.66106893
174regulation of amino acid transport (GO:0051955)2.65172650
175regulation of beta-amyloid formation (GO:1902003)2.64434722
176spinal cord motor neuron differentiation (GO:0021522)2.64276187
177purine deoxyribonucleotide metabolic process (GO:0009151)2.64127736
178positive regulation of synapse assembly (GO:0051965)2.63473195
179organelle disassembly (GO:1903008)2.62951256
180regulation of peptide transport (GO:0090087)2.62458215
181nitric oxide mediated signal transduction (GO:0007263)2.62254256
182hormone secretion (GO:0046879)2.62047257
183positive regulation of meiotic cell cycle (GO:0051446)2.60797303
184eosinophil chemotaxis (GO:0048245)2.59415151
185regulation of oxidative phosphorylation (GO:0002082)2.59288253
186regulation of neurotransmitter secretion (GO:0046928)2.58441172
187negative regulation of inclusion body assembly (GO:0090084)10.7459354

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.08243243
2EZH2_22144423_ChIP-Seq_EOC_Human4.68742221
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.50772533
4GBX2_23144817_ChIP-Seq_PC3_Human3.01570531
5IGF1R_20145208_ChIP-Seq_DFB_Human2.76882134
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.56271577
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38377028
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36010944
9TAF15_26573619_Chip-Seq_HEK293_Human2.29432152
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28705601
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.27297079
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20905231
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20371421
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16582170
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15376823
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15017208
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14934051
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.05137303
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03917241
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03180915
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02858572
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97849618
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96032982
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93158026
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.92356223
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90874667
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89692655
28ZNF274_21170338_ChIP-Seq_K562_Hela1.88647299
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86435147
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82458090
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75558324
32SMAD4_21799915_ChIP-Seq_A2780_Human1.72838333
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.69807596
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.69601771
35P300_19829295_ChIP-Seq_ESCs_Human1.67598744
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.61767132
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.57203490
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56780909
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56575490
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55492652
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.53600328
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51813773
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51275470
44IRF1_19129219_ChIP-ChIP_H3396_Human1.50990144
45VDR_22108803_ChIP-Seq_LS180_Human1.50812644
46RNF2_27304074_Chip-Seq_NSC_Mouse1.49707059
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45120337
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45120337
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44033561
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42402439
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40666625
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40666625
53REST_19997604_ChIP-ChIP_NEURONS_Mouse1.38683908
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36564613
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36481349
56FUS_26573619_Chip-Seq_HEK293_Human1.36197169
57CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34644658
58RARB_27405468_Chip-Seq_BRAIN_Mouse1.34422734
59EWS_26573619_Chip-Seq_HEK293_Human1.34152259
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34076818
61CBP_20019798_ChIP-Seq_JUKART_Human1.34076818
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30081381
63DROSHA_22980978_ChIP-Seq_HELA_Human1.29896347
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.29507953
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28696248
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.27896998
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27272805
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26828673
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24815423
70STAT3_23295773_ChIP-Seq_U87_Human1.23732138
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.23507749
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.23097274
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.22874956
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19789840
75ER_23166858_ChIP-Seq_MCF-7_Human1.19045934
76WDR5_24793694_ChIP-Seq_LNCAP_Human1.18984522
77GATA1_22025678_ChIP-Seq_K562_Human1.17651206
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.17587213
79RUNX2_22187159_ChIP-Seq_PCA_Human1.15920375
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15800472
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.14929999
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13469756
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13053077
84AR_25329375_ChIP-Seq_VCAP_Human1.12694970
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10588690
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09824137
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.09302333
88MYC_19829295_ChIP-Seq_ESCs_Human1.08880066
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08071957
90* TCF4_23295773_ChIP-Seq_U87_Human1.05757762
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05711914
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04026821
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03069687
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02944080
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01703009
96NANOG_19829295_ChIP-Seq_ESCs_Human1.00983534
97SOX2_19829295_ChIP-Seq_ESCs_Human1.00983534
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00861600
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99631521
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99514021
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99413703
102FLI1_21867929_ChIP-Seq_TH2_Mouse0.98884843
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98869811
104KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98645454
105FOXH1_21741376_ChIP-Seq_EPCs_Human0.98470573
106ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97823028
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97513878
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97441205
109SALL1_21062744_ChIP-ChIP_HESCs_Human0.97437250
110HTT_18923047_ChIP-ChIP_STHdh_Human0.97378464
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97171177
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.97075705
113TAL1_26923725_Chip-Seq_HPCs_Mouse0.96776983
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96483365
115* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96463052
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96178116
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96066058
118TCF4_22108803_ChIP-Seq_LS180_Human0.94768745
119KDM2B_26808549_Chip-Seq_REH_Human0.94249455
120JUN_21703547_ChIP-Seq_K562_Human0.91611653
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91295638
122BCAT_22108803_ChIP-Seq_LS180_Human0.91253398
123TP53_22573176_ChIP-Seq_HFKS_Human0.91207891
124TAF2_19829295_ChIP-Seq_ESCs_Human0.91162405
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.91075251
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90453756
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90174433
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90170832
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.90018720
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89647238
131CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88660193
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87045662
133* P53_22387025_ChIP-Seq_ESCs_Mouse0.86990956
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86662030
135* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85373200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis8.94102095
2MP0000013_abnormal_adipose_tissue4.10854213
3MP0005645_abnormal_hypothalamus_physiol4.08661541
4MP0003122_maternal_imprinting3.79835490
5MP0005410_abnormal_fertilization3.57495589
6MP0002837_dystrophic_cardiac_calcinosis3.56295083
7MP0005379_endocrine/exocrine_gland_phen3.50031486
8MP0010386_abnormal_urinary_bladder3.01004683
9MP0006276_abnormal_autonomic_nervous3.00163846
10MP0002909_abnormal_adrenal_gland2.90589890
11MP0003183_abnormal_peptide_metabolism2.89507883
12MP0001529_abnormal_vocalization2.70919951
13MP0003136_yellow_coat_color2.60147292
14MP0003880_abnormal_central_pattern2.55762761
15MP0004043_abnormal_pH_regulation2.53890117
16MP0002693_abnormal_pancreas_physiology2.35952308
17MP0009780_abnormal_chondrocyte_physiolo2.34014031
18MP0006072_abnormal_retinal_apoptosis2.32125819
19MP0004270_analgesia2.21947667
20MP0003283_abnormal_digestive_organ2.20971997
21MP0005187_abnormal_penis_morphology2.19214718
22MP0003635_abnormal_synaptic_transmissio2.16563186
23MP0001944_abnormal_pancreas_morphology2.12870635
24MP0000372_irregular_coat_pigmentation2.12705108
25MP0002163_abnormal_gland_morphology2.11159730
26MP0002734_abnormal_mechanical_nocicepti2.05720926
27MP0005646_abnormal_pituitary_gland2.03215823
28MP0010030_abnormal_orbit_morphology2.00700735
29MP0008789_abnormal_olfactory_epithelium1.99671061
30MP0002064_seizures1.98562409
31MP0009745_abnormal_behavioral_response1.96859749
32MP0003195_calcinosis1.88740131
33MP0003718_maternal_effect1.87717776
34MP0002572_abnormal_emotion/affect_behav1.87661715
35MP0005499_abnormal_olfactory_system1.86625314
36MP0005394_taste/olfaction_phenotype1.86625314
37MP0003315_abnormal_perineum_morphology1.86245323
38MP0009046_muscle_twitch1.85602308
39MP0002876_abnormal_thyroid_physiology1.78839011
40MP0001440_abnormal_grooming_behavior1.78560445
41MP0002733_abnormal_thermal_nociception1.78312976
42MP0001968_abnormal_touch/_nociception1.75754313
43MP0002638_abnormal_pupillary_reflex1.75684989
44MP0002877_abnormal_melanocyte_morpholog1.75494484
45MP0001986_abnormal_taste_sensitivity1.75360433
46MP0002272_abnormal_nervous_system1.73273223
47MP0001501_abnormal_sleep_pattern1.72604958
48MP0000003_abnormal_adipose_tissue1.72423678
49MP0004742_abnormal_vestibular_system1.66918756
50MP0002063_abnormal_learning/memory/cond1.66557131
51MP0001502_abnormal_circadian_rhythm1.62114719
52MP0002735_abnormal_chemical_nociception1.61306610
53MP0005171_absent_coat_pigmentation1.61002750
54MP0001970_abnormal_pain_threshold1.59651586
55MP0002653_abnormal_ependyma_morphology1.59260025
56MP0002938_white_spotting1.58144495
57MP0004859_abnormal_synaptic_plasticity1.55507923
58MP0005423_abnormal_somatic_nervous1.55187646
59MP0003121_genomic_imprinting1.51849652
60MP0006292_abnormal_olfactory_placode1.49160588
61MP0000631_abnormal_neuroendocrine_gland1.48062635
62MP0004142_abnormal_muscle_tone1.47730425
63MP0002078_abnormal_glucose_homeostasis1.45191391
64MP0008877_abnormal_DNA_methylation1.42300358
65MP0002160_abnormal_reproductive_system1.40521074
66MP0002557_abnormal_social/conspecific_i1.40396233
67MP0003938_abnormal_ear_development1.39845919
68MP0005386_behavior/neurological_phenoty1.36703088
69MP0004924_abnormal_behavior1.36703088
70MP0005535_abnormal_body_temperature1.36491060
71MP0003787_abnormal_imprinting1.34422864
72MP0001905_abnormal_dopamine_level1.34293548
73MP0002067_abnormal_sensory_capabilities1.33713585
74MP0000678_abnormal_parathyroid_gland1.31405014
75MP0005670_abnormal_white_adipose1.30374344
76MP0003698_abnormal_male_reproductive1.27226659
77MP0001963_abnormal_hearing_physiology1.22918750
78MP0002184_abnormal_innervation1.21917678
79MP0001188_hyperpigmentation1.21262205
80MP0001984_abnormal_olfaction1.19228786
81MP0002736_abnormal_nociception_after1.19213614
82MP0003959_abnormal_lean_body1.16176482
83MP0001486_abnormal_startle_reflex1.15876390
84MP0001293_anophthalmia1.15303508
85MP0000026_abnormal_inner_ear1.14608948
86MP0001765_abnormal_ion_homeostasis1.13582237
87MP0005220_abnormal_exocrine_pancreas1.12760664
88MP0008961_abnormal_basal_metabolism1.11558399
89MP0001929_abnormal_gametogenesis1.08383065
90MP0003890_abnormal_embryonic-extraembry1.06292990
91MP0004145_abnormal_muscle_electrophysio1.06284059
92MP0005623_abnormal_meninges_morphology1.06201692
93MP0003953_abnormal_hormone_level1.04526343
94MP0003123_paternal_imprinting1.03000576
95MP0002928_abnormal_bile_duct1.01744493
96MP0004133_heterotaxia1.01009602
97MP0005253_abnormal_eye_physiology1.00429689
98MP0000537_abnormal_urethra_morphology0.99958003
99MP0002822_catalepsy0.99395709
100MP0000538_abnormal_urinary_bladder0.98120385
101MP0008995_early_reproductive_senescence0.98070213
102MP0002069_abnormal_eating/drinking_beha0.95965031
103MP0005377_hearing/vestibular/ear_phenot0.95553594
104MP0003878_abnormal_ear_physiology0.95553594
105MP0003879_abnormal_hair_cell0.92542860
106MP0001664_abnormal_digestion0.91766660
107MP0000955_abnormal_spinal_cord0.89880334
108MP0002282_abnormal_trachea_morphology0.88083636
109MP0005551_abnormal_eye_electrophysiolog0.86942963
110MP0002752_abnormal_somatic_nervous0.86634223
111MP0000639_abnormal_adrenal_gland0.86565940
112MP0002066_abnormal_motor_capabilities/c0.85609887
113MP0000749_muscle_degeneration0.84671390
114MP0003172_abnormal_lysosome_physiology0.82964388
115MP0000230_abnormal_systemic_arterial0.82180542
116MP0005448_abnormal_energy_balance0.80157957
117MP0005058_abnormal_lysosome_morphology0.79852094
118MP0004885_abnormal_endolymph0.79553203
119MP0002229_neurodegeneration0.78517270
120MP0002152_abnormal_brain_morphology0.77345713
121MP0002882_abnormal_neuron_morphology0.77176323
122MP0003828_pulmonary_edema0.76652916
123MP0002751_abnormal_autonomic_nervous0.76359485
124MP0002234_abnormal_pharynx_morphology0.75552950
125MP0002161_abnormal_fertility/fecundity0.75515024
126MP0001299_abnormal_eye_distance/0.75132815
127MP0002102_abnormal_ear_morphology0.75032941
128MP0005408_hypopigmentation0.74648268
129MP0001485_abnormal_pinna_reflex0.74545084
130MP0003633_abnormal_nervous_system0.74415086
131MP0002210_abnormal_sex_determination0.74342466
132MP0003868_abnormal_feces_composition0.74249423
133MP0005084_abnormal_gallbladder_morpholo0.72543368
134MP0004085_abnormal_heartbeat0.72523319
135MP0001764_abnormal_homeostasis0.70413024
136MP0005391_vision/eye_phenotype0.70178000
137MP0004811_abnormal_neuron_physiology0.69541691
138MP0008569_lethality_at_weaning0.69444837
139MP0005636_abnormal_mineral_homeostasis0.69283192
140MP0003329_amyloid_beta_deposits0.69252856
141MP0001756_abnormal_urination0.67780855
142MP0000778_abnormal_nervous_system0.66753595
143MP0005310_abnormal_salivary_gland0.66503880
144MP0000579_abnormal_nail_morphology0.65385933
145MP0002090_abnormal_vision0.64959747
146MP0003634_abnormal_glial_cell0.63976939
147MP0005452_abnormal_adipose_tissue0.62784638

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)6.05824786
2Small epiphyses (HP:0010585)5.64263265
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.55771061
4Axonal loss (HP:0003447)5.43992717
5Hyperinsulinemic hypoglycemia (HP:0000825)4.99949371
6Hypoglycemic seizures (HP:0002173)4.48905902
7Symptomatic seizures (HP:0011145)4.33546523
8Abnormality of calcium-phosphate metabolism (HP:0100530)4.24708675
9Acute necrotizing encephalopathy (HP:0006965)3.96595945
10Flattened epiphyses (HP:0003071)3.91494461
11Hypothermia (HP:0002045)3.86574258
12Bile duct proliferation (HP:0001408)3.86060979
13Abnormal biliary tract physiology (HP:0012439)3.86060979
14Oligodactyly (hands) (HP:0001180)3.84804803
15Diaphragmatic weakness (HP:0009113)3.82294312
16Cupped ribs (HP:0000887)3.79449402
17Abnormal mitochondria in muscle tissue (HP:0008316)3.76263050
18Atonic seizures (HP:0010819)3.66585541
19Ulnar bowing (HP:0003031)3.66336682
20Agitation (HP:0000713)3.62748113
21Visual hallucinations (HP:0002367)3.59810839
22Myokymia (HP:0002411)3.57941619
23Focal motor seizures (HP:0011153)3.56723713
24Progressive macrocephaly (HP:0004481)3.45254998
25Severe visual impairment (HP:0001141)3.38763365
26Nephronophthisis (HP:0000090)3.37949488
27Failure to thrive in infancy (HP:0001531)3.36171267
28Progressive cerebellar ataxia (HP:0002073)3.34609866
29Pheochromocytoma (HP:0002666)3.27708366
30Acute encephalopathy (HP:0006846)3.26575517
31Flared iliac wings (HP:0002869)3.22878314
32Hyperglycemia (HP:0003074)3.20523202
33Split foot (HP:0001839)3.18354713
34Absence seizures (HP:0002121)3.17059412
35Decreased circulating renin level (HP:0003351)3.12569950
36Metaphyseal cupping (HP:0003021)3.09790872
37Oligomenorrhea (HP:0000876)3.05736019
38Neuroendocrine neoplasm (HP:0100634)3.05402306
39Mitochondrial inheritance (HP:0001427)3.04402943
40True hermaphroditism (HP:0010459)3.02412427
41Intellectual disability, moderate (HP:0002342)3.01672622
42Abnormality of endocrine pancreas physiology (HP:0012093)2.99344872
43Abnormality of the pancreatic islet cells (HP:0006476)2.99344872
44Radial bowing (HP:0002986)2.97374869
45Ketoacidosis (HP:0001993)2.96283586
463-Methylglutaconic aciduria (HP:0003535)2.95696286
47Insulin-resistant diabetes mellitus (HP:0000831)2.92453905
48Gait imbalance (HP:0002141)2.87438886
49Medial flaring of the eyebrow (HP:0010747)2.86420939
50Large for gestational age (HP:0001520)2.86076347
51Occipital encephalocele (HP:0002085)2.85424903
52EEG with generalized epileptiform discharges (HP:0011198)2.81509522
53Hypoglycemic coma (HP:0001325)2.80957000
54Limb dystonia (HP:0002451)2.80637863
55Irregular vertebral endplates (HP:0003301)2.77902281
56Generalized aminoaciduria (HP:0002909)2.77376278
57Congenital primary aphakia (HP:0007707)2.76348724
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.75394206
59Epileptiform EEG discharges (HP:0011182)2.75006365
60Menstrual irregularities (HP:0000858)2.73885116
61Dialeptic seizures (HP:0011146)2.73291494
62Hypsarrhythmia (HP:0002521)2.69971577
63Pancreatic islet-cell hyperplasia (HP:0004510)2.68463380
64Late onset (HP:0003584)2.67635386
65Rhinitis (HP:0012384)2.65424391
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.64623760
67Limited elbow extension (HP:0001377)2.63404322
68Abnormal hair whorl (HP:0010721)2.63386011
69Pancreatic fibrosis (HP:0100732)2.63082513
70Anterior segment dysgenesis (HP:0007700)2.62813754
71Rapidly progressive (HP:0003678)2.62215093
72Oligodactyly (HP:0012165)2.60673097
73Amblyopia (HP:0000646)2.60247630
74Molar tooth sign on MRI (HP:0002419)2.57404974
75Abnormality of midbrain morphology (HP:0002418)2.57404974
76Generalized tonic-clonic seizures (HP:0002069)2.55800827
77Abnormality of macular pigmentation (HP:0008002)2.55256756
78Retinal atrophy (HP:0001105)2.54061654
79Abnormality of the renal medulla (HP:0100957)2.53141957
80Abnormality of the vertebral endplates (HP:0005106)2.51573502
81Nephrogenic diabetes insipidus (HP:0009806)2.50574224
82Abnormal pancreas size (HP:0012094)2.47749257
83Dysostosis multiplex (HP:0000943)2.47074138
84Focal seizures (HP:0007359)2.45406625
85Anxiety (HP:0000739)2.41846646
86Increased CSF lactate (HP:0002490)2.38119273
87Abnormal respiratory motile cilium physiology (HP:0012261)2.35728907
88Growth hormone deficiency (HP:0000824)2.34198951
89Polyphagia (HP:0002591)2.33403964
90Hyperparathyroidism (HP:0000843)2.31342809
91Febrile seizures (HP:0002373)2.29631342
92Optic nerve hypoplasia (HP:0000609)2.28433503
93Postural instability (HP:0002172)2.26491327
94Poor suck (HP:0002033)2.24794912
95Epileptic encephalopathy (HP:0200134)2.24436647
96Hypokalemia (HP:0002900)2.23744234
97Anosmia (HP:0000458)2.21259836
98Septo-optic dysplasia (HP:0100842)2.18004875
99Abnormal respiratory motile cilium morphology (HP:0005938)2.17041765
100Abnormal respiratory epithelium morphology (HP:0012253)2.17041765
101Pancreatic cysts (HP:0001737)2.16624326
102Osteomalacia (HP:0002749)2.15127684
103Vaginal atresia (HP:0000148)2.14512135
104Bony spicule pigmentary retinopathy (HP:0007737)2.13489341
105Hepatocellular necrosis (HP:0001404)2.11904049
106Genital tract atresia (HP:0001827)2.11348685
107Dysautonomia (HP:0002459)2.10353791
108Abnormal pupillary function (HP:0007686)2.09922229
109Psychosis (HP:0000709)2.09814606
110Tachypnea (HP:0002789)2.07286419
111Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07152227
112Restlessness (HP:0000711)2.06559289
113Abnormal ciliary motility (HP:0012262)2.06488642
114Amelogenesis imperfecta (HP:0000705)2.05885592
115Abnormality of renin-angiotensin system (HP:0000847)2.05877159
116Hypoventilation (HP:0002791)2.05845839
117Portal hypertension (HP:0001409)2.05638967
118Amyotrophic lateral sclerosis (HP:0007354)2.04985247
119Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02974489
120Hyperphosphaturia (HP:0003109)2.01122524
121Cone-rod dystrophy (HP:0000548)2.00457066
122Sclerocornea (HP:0000647)2.00056950
123Urinary glycosaminoglycan excretion (HP:0003541)1.99490456
124Mucopolysacchariduria (HP:0008155)1.99490456
125Bradykinesia (HP:0002067)1.99194658
126Delayed CNS myelination (HP:0002188)1.98623205
127Abnormal drinking behavior (HP:0030082)1.98311252
128Polydipsia (HP:0001959)1.98311252
129Type II lissencephaly (HP:0007260)1.98095762
130Dyskinesia (HP:0100660)1.95871467
131Cystic liver disease (HP:0006706)1.95502761
132Akinesia (HP:0002304)1.95290134
133Hypercortisolism (HP:0001578)1.94510385
134Aplasia/hypoplasia of the uterus (HP:0008684)1.94352067
135Hemiparesis (HP:0001269)1.92780283
136Bowing of the arm (HP:0006488)1.91834579
137Bowed forearm bones (HP:0003956)1.91834579
138Femoral bowing (HP:0002980)1.91549995
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90388497
140Optic disc pallor (HP:0000543)1.90244212
141Recurrent corneal erosions (HP:0000495)1.90220487
142Diplopia (HP:0000651)1.89402112
143Abnormality of binocular vision (HP:0011514)1.89402112
144Conjugated hyperbilirubinemia (HP:0002908)1.89264397
145Abnormality of the hepatic vasculature (HP:0006707)1.88961345
146Focal dystonia (HP:0004373)1.88877503
147Papilledema (HP:0001085)1.86922028
148Hepatic necrosis (HP:0002605)1.86661469
149Infertility (HP:0000789)1.86615363
150Cortical visual impairment (HP:0100704)1.85463220
151Postural tremor (HP:0002174)1.84831197
152Easy fatigability (HP:0003388)1.84324468
153Progressive neurologic deterioration (HP:0002344)1.83946666
154Volvulus (HP:0002580)1.83345270
155Truncal obesity (HP:0001956)1.83254203
156Abnormality of potassium homeostasis (HP:0011042)1.83057568
157Abnormal eating behavior (HP:0100738)1.82278661
158Congenital sensorineural hearing impairment (HP:0008527)1.82244966
159Tubulointerstitial nephritis (HP:0001970)1.81332220
160Absent septum pellucidum (HP:0001331)1.80966602
161Aplasia/Hypoplasia of the lens (HP:0008063)1.80391892
162Growth hormone excess (HP:0000845)1.79193720
163Hyperphosphatemia (HP:0002905)1.79179147
164Abnormality of the intrinsic pathway (HP:0010989)1.78420653
165Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78017213
166Abnormality of polysaccharide metabolism (HP:0011012)1.78017213
167Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78017213
168Muscular hypotonia of the trunk (HP:0008936)1.77696140
169Decreased central vision (HP:0007663)1.77089758
170Hyperkalemia (HP:0002153)1.77070643
171Knee flexion contracture (HP:0006380)1.76384125
172Supernumerary spleens (HP:0009799)1.76143583
173Cerebral edema (HP:0002181)1.75954261
174Absent hand (HP:0004050)1.75876028
175Tibial bowing (HP:0002982)1.75836425
176Bifid tongue (HP:0010297)1.75634241
177Orthostatic hypotension (HP:0001278)1.75489910
178Increased hepatocellular lipid droplets (HP:0006565)1.74850915
179Testicular neoplasm (HP:0010788)1.74625721
180Abnormality of the fovea (HP:0000493)1.74619725
181Atrophy/Degeneration involving motor neurons (HP:0007373)1.68535420
182Stenosis of the external auditory canal (HP:0000402)1.68400865
183Short nail (HP:0001799)1.66393350
184Nasal polyposis (HP:0100582)1.66337401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.14332193
2INSRR3.97367614
3WNK33.68274071
4PLK43.49236621
5NTRK33.43447857
6FRK2.87007529
7PRKD32.70269022
8MAP3K122.67866365
9BCKDK2.67055797
10WNK42.48752538
11PNCK2.38782602
12EPHA42.35069564
13MAP3K22.32625503
14TAOK32.29514334
15PASK2.28161413
16UHMK12.18041989
17MAP3K42.14145118
18PIK3CG2.00507857
19ARAF1.96921684
20CASK1.87229721
21TYRO31.81933241
22HIPK21.80323196
23NME11.78065699
24MAP2K71.77819583
25CAMKK21.69719858
26MAP3K91.68355719
27AKT31.64268222
28SIK21.57953101
29ADRBK21.47723594
30NTRK11.45070783
31GRK71.44429219
32IRAK31.43294012
33EPHB21.41328451
34MAP2K41.38497819
35MARK11.38369123
36NTRK21.34857393
37PAK31.34255711
38BRAF1.30346605
39MAP3K11.25938789
40TLK11.23825675
41DYRK21.21888038
42DDR21.18000264
43MINK11.17942951
44MAP3K111.15874153
45PINK11.15048967
46IRAK11.13141453
47MAPK131.06223569
48SRPK11.05612755
49CAMK2D1.04425457
50CSNK1G11.02313329
51IRAK21.01926159
52TNIK0.99304194
53CAMKK10.99156258
54CAMK2A0.96626134
55GRK50.96091386
56CDC42BPA0.94342834
57EPHA30.92943137
58MAP3K50.92369996
59CAMK2B0.91999327
60DYRK1B0.91855611
61PRKCH0.90171822
62PRKCE0.89948636
63PKN10.89525099
64KSR20.87799449
65CDK50.85607726
66WNK10.83035241
67FLT30.82577040
68EIF2AK30.80449151
69MARK20.80144856
70ADRBK10.80142884
71BMPR1B0.79877120
72STK160.79258756
73CDK190.78599662
74TSSK60.78432165
75DYRK30.78258180
76FER0.75600072
77BMPR20.75333874
78PRKCG0.74312680
79SIK30.72898682
80CSNK1A1L0.72483034
81FGFR20.71232001
82CAMK2G0.69521927
83BCR0.69056700
84STK390.68847399
85PRKD20.65063647
86MAP4K20.62215630
87CAMK1G0.61807242
88MAP3K70.61638977
89SGK2230.61402708
90SGK4940.61402708
91CDK180.57383245
92MAP3K130.57312462
93PRKACA0.56115854
94TRIM280.56026793
95CDK150.55764937
96MARK30.55434476
97CDK140.55307795
98RPS6KA20.54604683
99SCYL20.54394851
100MYLK0.53829540
101CSNK1G20.53576570
102CDK11A0.53516766
103TIE10.51008869
104MAPKAPK50.48239932
105FES0.47649495
106PDK10.47105313
107SGK20.46265184
108CDK90.45932187
109PIK3CA0.44767325
110LMTK20.43721332
111PTK20.43549275
112CSNK1G30.42345799
113DAPK10.42287369
114TGFBR10.42134548
115SGK10.41840950
116CAMK40.40165619
117RPS6KB10.39839944
118RET0.39734814
119TNK20.38358916
120PRKG10.37893695
121PRKCZ0.37352089
122BRSK20.37350994
123CAMK10.37023708
124PRKCA0.36591497
125RPS6KA30.36369257
126DYRK1A0.36303598
127PRKACG0.36011992
128PHKG20.35115945
129PHKG10.35115945
130TESK10.34391848
131CSNK1A10.34161381
132OXSR10.33587924
133BRD40.33523845
134ERBB30.33479624
135VRK10.33293270
136PLK20.32788210
137PAK60.31933291
138GSK3A0.30977732
139PRKCB0.30786564
140PLK30.30298923
141MAP2K10.29763910
142PRKCI0.29410137
143NEK60.29047033
144AKT20.28848871
145STK110.28818533
146CDK30.28111046
147PRKG20.27924286
148MOS0.27392544
149PRKACB0.25969520

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.13836863
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.49459083
3Protein export_Homo sapiens_hsa030604.35414637
4Oxidative phosphorylation_Homo sapiens_hsa001903.40313248
5Insulin secretion_Homo sapiens_hsa049112.97037820
6Collecting duct acid secretion_Homo sapiens_hsa049662.68229326
7Vibrio cholerae infection_Homo sapiens_hsa051102.62565042
8Parkinsons disease_Homo sapiens_hsa050122.55100990
9Nicotine addiction_Homo sapiens_hsa050332.48747795
10Synaptic vesicle cycle_Homo sapiens_hsa047212.48554280
11GABAergic synapse_Homo sapiens_hsa047272.18686511
12Alzheimers disease_Homo sapiens_hsa050102.18174694
13Type I diabetes mellitus_Homo sapiens_hsa049402.05811636
14Taste transduction_Homo sapiens_hsa047421.96260521
15Cocaine addiction_Homo sapiens_hsa050301.95093676
16Sulfur metabolism_Homo sapiens_hsa009201.95075426
17Amphetamine addiction_Homo sapiens_hsa050311.92538368
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86578708
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80272412
20Huntingtons disease_Homo sapiens_hsa050161.75856239
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72416149
22Morphine addiction_Homo sapiens_hsa050321.69903106
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62003023
24Serotonergic synapse_Homo sapiens_hsa047261.58351840
25Circadian entrainment_Homo sapiens_hsa047131.55242795
26Hedgehog signaling pathway_Homo sapiens_hsa043401.54072975
27Dopaminergic synapse_Homo sapiens_hsa047281.52571334
28Long-term potentiation_Homo sapiens_hsa047201.45695309
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35185674
30Type II diabetes mellitus_Homo sapiens_hsa049301.34800547
31Legionellosis_Homo sapiens_hsa051341.34778171
32Cardiac muscle contraction_Homo sapiens_hsa042601.32457417
33Renin secretion_Homo sapiens_hsa049241.26123799
34Cholinergic synapse_Homo sapiens_hsa047251.22167041
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20547788
36Long-term depression_Homo sapiens_hsa047301.19453165
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18433022
38Glutamatergic synapse_Homo sapiens_hsa047241.16409717
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15853848
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15852586
41Folate biosynthesis_Homo sapiens_hsa007901.14536821
42Olfactory transduction_Homo sapiens_hsa047401.11400491
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06462161
44Axon guidance_Homo sapiens_hsa043601.02267470
45Sulfur relay system_Homo sapiens_hsa041221.01593065
46Thyroid hormone synthesis_Homo sapiens_hsa049180.97589093
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96112780
48Regulation of autophagy_Homo sapiens_hsa041400.94560611
49Glucagon signaling pathway_Homo sapiens_hsa049220.91248934
50Basal transcription factors_Homo sapiens_hsa030220.90884209
51N-Glycan biosynthesis_Homo sapiens_hsa005100.90492638
52Prion diseases_Homo sapiens_hsa050200.89134442
53Estrogen signaling pathway_Homo sapiens_hsa049150.88797946
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.87661815
55Gastric acid secretion_Homo sapiens_hsa049710.86798994
56Circadian rhythm_Homo sapiens_hsa047100.85222206
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84960293
58Salivary secretion_Homo sapiens_hsa049700.82611423
59Pancreatic secretion_Homo sapiens_hsa049720.81907889
60Rheumatoid arthritis_Homo sapiens_hsa053230.80110110
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.78465484
62Oocyte meiosis_Homo sapiens_hsa041140.77811501
63Basal cell carcinoma_Homo sapiens_hsa052170.76536084
64Lysosome_Homo sapiens_hsa041420.76024673
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75398234
66Bile secretion_Homo sapiens_hsa049760.74728321
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74523124
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73729404
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72529097
70Calcium signaling pathway_Homo sapiens_hsa040200.72197705
71Nitrogen metabolism_Homo sapiens_hsa009100.71196069
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70247913
73GnRH signaling pathway_Homo sapiens_hsa049120.70068097
74Oxytocin signaling pathway_Homo sapiens_hsa049210.69552674
75Butanoate metabolism_Homo sapiens_hsa006500.69328205
76Proteasome_Homo sapiens_hsa030500.66076357
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63242337
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.62173338
79Antigen processing and presentation_Homo sapiens_hsa046120.62148849
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61124777
81Other glycan degradation_Homo sapiens_hsa005110.60569851
82Phagosome_Homo sapiens_hsa041450.59598527
83cAMP signaling pathway_Homo sapiens_hsa040240.58324004
84Dorso-ventral axis formation_Homo sapiens_hsa043200.58081442
85Gap junction_Homo sapiens_hsa045400.57445339
86Alcoholism_Homo sapiens_hsa050340.56610940
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55456037
88PPAR signaling pathway_Homo sapiens_hsa033200.54665135
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54132329
90Melanogenesis_Homo sapiens_hsa049160.53387362
91Sphingolipid metabolism_Homo sapiens_hsa006000.50390159
92Purine metabolism_Homo sapiens_hsa002300.50269249
93Protein digestion and absorption_Homo sapiens_hsa049740.50218215
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49776124
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49562564
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49048685
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48753289
98Fatty acid biosynthesis_Homo sapiens_hsa000610.46697740
99Spliceosome_Homo sapiens_hsa030400.46696014
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42746776
101Phototransduction_Homo sapiens_hsa047440.42416605
102Steroid biosynthesis_Homo sapiens_hsa001000.42376766
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40345252
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40084884
105Phenylalanine metabolism_Homo sapiens_hsa003600.39198451
106Wnt signaling pathway_Homo sapiens_hsa043100.39138416
107Linoleic acid metabolism_Homo sapiens_hsa005910.39128712
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.37885967
109Galactose metabolism_Homo sapiens_hsa000520.37872959
110Tyrosine metabolism_Homo sapiens_hsa003500.37612136
111Ras signaling pathway_Homo sapiens_hsa040140.36389651
112Ether lipid metabolism_Homo sapiens_hsa005650.35752447
113Ovarian steroidogenesis_Homo sapiens_hsa049130.35132946
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33010929
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29613213
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.29536748
117Homologous recombination_Homo sapiens_hsa034400.28964505
118Insulin signaling pathway_Homo sapiens_hsa049100.28537404
119TGF-beta signaling pathway_Homo sapiens_hsa043500.26773618
120RNA degradation_Homo sapiens_hsa030180.26000607
121Dilated cardiomyopathy_Homo sapiens_hsa054140.25778237
122Mismatch repair_Homo sapiens_hsa034300.25237812
123Metabolic pathways_Homo sapiens_hsa011000.24275322
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24112167
125Caffeine metabolism_Homo sapiens_hsa002320.23677377
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23248590
127Prolactin signaling pathway_Homo sapiens_hsa049170.23211305
128Inositol phosphate metabolism_Homo sapiens_hsa005620.23172543
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23087557
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20413542
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18962015
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18611574
133ABC transporters_Homo sapiens_hsa020100.16558888
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15558514
135ErbB signaling pathway_Homo sapiens_hsa040120.15416066
136MAPK signaling pathway_Homo sapiens_hsa040100.15198947

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