RERGL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)9.97648390
2N-acetylneuraminate metabolic process (GO:0006054)9.21951404
3centriole replication (GO:0007099)7.99044081
4positive regulation of histone deacetylation (GO:0031065)7.75265150
5protoporphyrinogen IX metabolic process (GO:0046501)7.64826153
6cellular extravasation (GO:0045123)7.53884495
7insulin-like growth factor receptor signaling pathway (GO:0048009)7.18147781
8regulation of MHC class II biosynthetic process (GO:0045346)6.62653134
9negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)6.54951518
10amino sugar catabolic process (GO:0046348)6.18688768
11positive regulation of protein deacetylation (GO:0090312)5.85776568
12N-acetylglucosamine metabolic process (GO:0006044)5.67208337
13reactive oxygen species biosynthetic process (GO:1903409)5.40355289
14purine deoxyribonucleotide catabolic process (GO:0009155)5.36070771
15positive regulation of chemokine biosynthetic process (GO:0045080)5.32747036
16positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.30733259
17centriole assembly (GO:0098534)5.24718636
18microglial cell activation (GO:0001774)5.14558918
19regulation of synapse structural plasticity (GO:0051823)5.08647516
20negative regulation of phagocytosis (GO:0050765)5.02726816
21thalamus development (GO:0021794)4.99169968
22base-excision repair, AP site formation (GO:0006285)4.94982268
23regulation of chemokine biosynthetic process (GO:0045073)4.81855358
24cellular response to cadmium ion (GO:0071276)4.66993005
25macrophage chemotaxis (GO:0048246)4.65913475
26cytokinetic process (GO:0032506)4.48188084
27negative regulation of growth of symbiont in host (GO:0044130)4.44986167
28negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.44986167
29modulation of growth of symbiont involved in interaction with host (GO:0044144)4.44986167
30regulation of growth of symbiont in host (GO:0044126)4.44986167
31negative regulation of interleukin-2 production (GO:0032703)4.37704710
32response to misfolded protein (GO:0051788)4.36987408
33response to folic acid (GO:0051593)4.36296506
34disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.28521200
35killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.28521200
36regulation of histone deacetylation (GO:0031063)4.15792383
37angiotensin maturation (GO:0002003)4.02119757
38behavioral response to nicotine (GO:0035095)3.98974810
39low-density lipoprotein particle remodeling (GO:0034374)3.96317034
40glial cell migration (GO:0008347)3.85578549
41regulation of fatty acid transport (GO:2000191)3.83511782
42DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.76201512
43prostate gland growth (GO:0060736)3.68483590
44G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.66703691
45cGMP-mediated signaling (GO:0019934)3.65838911
46positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.64361522
47signal complex assembly (GO:0007172)3.60869718
48induction of positive chemotaxis (GO:0050930)3.54246387
49heme biosynthetic process (GO:0006783)3.54195925
50regulation of protein import into nucleus, translocation (GO:0033158)3.40857390
51polyol transport (GO:0015791)3.40351885
52positive regulation of dendritic spine development (GO:0060999)3.39827000
53DNA damage response, signal transduction resulting in transcription (GO:0042772)3.30350098
54glomerular visceral epithelial cell development (GO:0072015)3.27196529
55neutrophil mediated immunity (GO:0002446)3.20934800
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19227533
57regulation of glycolytic process (GO:0006110)3.17779332
58regulation of sequestering of triglyceride (GO:0010889)3.15133653
59glomerular filtration (GO:0003094)3.13281241
60glucosamine-containing compound metabolic process (GO:1901071)3.08053338
61response to oxygen radical (GO:0000305)3.06399692
62regulation of vascular permeability (GO:0043114)3.04715503
63relaxation of smooth muscle (GO:0044557)3.04419507
64regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.03450484
65regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.03450484
66removal of superoxide radicals (GO:0019430)3.00355530
67cellular response to superoxide (GO:0071451)3.00355530
68cellular response to oxygen radical (GO:0071450)3.00355530
69regulation of G0 to G1 transition (GO:0070316)2.99450514
70regulation of protein deacetylation (GO:0090311)2.94130859
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91944820
72purine deoxyribonucleotide metabolic process (GO:0009151)2.86983041
73glomerular epithelial cell development (GO:0072310)2.84942032
74endothelium development (GO:0003158)2.83866887
75low-density lipoprotein particle clearance (GO:0034383)2.81896481
76regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.79782934
77gamma-aminobutyric acid transport (GO:0015812)2.77121103
78response to food (GO:0032094)2.75798427
79synaptic vesicle maturation (GO:0016188)2.72694275
80renal filtration (GO:0097205)2.66945276
81early endosome to late endosome transport (GO:0045022)2.64882743
82misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.64369217
83defense response to fungus (GO:0050832)2.63974425
84negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62629886
85regulation of organic acid transport (GO:0032890)2.61629801
86sodium-independent organic anion transport (GO:0043252)2.60395092
87somatic diversification of immunoglobulins (GO:0016445)2.52550155
88regulation of neurotransmitter uptake (GO:0051580)2.49625696
89response to superoxide (GO:0000303)2.48944101
90glutamate receptor signaling pathway (GO:0007215)2.47367544
91lymphangiogenesis (GO:0001946)2.46301232
92phosphatidylglycerol biosynthetic process (GO:0006655)2.45521526
93regulation of cellular carbohydrate catabolic process (GO:0043471)2.42877047
94regulation of carbohydrate catabolic process (GO:0043470)2.42877047
95anatomical structure regression (GO:0060033)2.40802711
96potassium ion import (GO:0010107)2.37374468
97regulation of p38MAPK cascade (GO:1900744)2.36586610
98cardiolipin metabolic process (GO:0032048)2.34235903
99heme metabolic process (GO:0042168)2.34051025
100hydrogen peroxide biosynthetic process (GO:0050665)2.30865114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.93614077
2IKZF1_21737484_ChIP-ChIP_HCT116_Human3.56404662
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11180878
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.11050784
5IGF1R_20145208_ChIP-Seq_DFB_Human2.53285828
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.30997571
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26295454
8GBX2_23144817_ChIP-Seq_PC3_Human2.19566444
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.11631540
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90402979
11DROSHA_22980978_ChIP-Seq_HELA_Human1.90092203
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79683552
13JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75466667
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73142424
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65191967
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64281729
17ER_23166858_ChIP-Seq_MCF-7_Human1.64057458
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58725768
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.54802437
20RXR_22108803_ChIP-Seq_LS180_Human1.54464052
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.53119827
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.52868156
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.51232716
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48046925
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47866400
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47144392
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.44825710
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42866025
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42327028
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42099661
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38373835
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.37293190
33SCL_19346495_ChIP-Seq_HPC-7_Human1.35089498
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34339778
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33910254
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28786516
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28786516
38BCAT_22108803_ChIP-Seq_LS180_Human1.25866318
39* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24166258
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22669337
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20958388
42CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18836108
43REST_21632747_ChIP-Seq_MESCs_Mouse1.16993210
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11531428
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08369763
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08307968
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03934491
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03340378
49ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02536283
50TCF4_23295773_ChIP-Seq_U87_Human1.02394181
51LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02123399
52LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01731422
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01380843
54TP53_20018659_ChIP-ChIP_R1E_Mouse0.93622206
55NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90804956
56LXR_22158963_ChIP-Seq_LIVER_Mouse0.89899181
57* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89893043
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89810220
59WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89172350
60BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88156375
61NANOG_19829295_ChIP-Seq_ESCs_Human0.87744979
62SOX2_19829295_ChIP-Seq_ESCs_Human0.87744979
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87442340
64TAF2_19829295_ChIP-Seq_ESCs_Human0.87012242
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86690398
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85054347
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85029360
68PIAS1_25552417_ChIP-Seq_VCAP_Human0.84771913
69IRF1_19129219_ChIP-ChIP_H3396_Human0.84334509
70RNF2_27304074_Chip-Seq_NSC_Mouse0.84185957
71AR_19668381_ChIP-Seq_PC3_Human0.83388406
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82006938
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81860410
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81717188
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80908347
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80834547
77* CJUN_26792858_Chip-Seq_BT549_Human0.80766463
78RING1B_27294783_Chip-Seq_ESCs_Mouse0.80640189
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80526208
80STAT3_23295773_ChIP-Seq_U87_Human0.79631567
81KLF4_19829295_ChIP-Seq_ESCs_Human0.79234854
82* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79206689
83SMAD4_21741376_ChIP-Seq_HESCs_Human0.79136897
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79065308
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78603011
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78216943
87RING1B_27294783_Chip-Seq_NPCs_Mouse0.77773430
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75779852
89* NANOG_20526341_ChIP-Seq_ESCs_Human0.75338128
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75032531
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74937561
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.74836554
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.74587906
94* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73567827
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72717245
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.72528219
97TBL1_22424771_ChIP-Seq_293T_Human0.72362604
98AR_25329375_ChIP-Seq_VCAP_Human0.72300378
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.72237551
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.72199373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract8.55250495
2MP0005670_abnormal_white_adipose6.20026070
3MP0008961_abnormal_basal_metabolism4.43914757
4MP0005365_abnormal_bile_salt4.03773553
5MP0004043_abnormal_pH_regulation3.41599418
6MP0003252_abnormal_bile_duct3.05242533
7MP0005085_abnormal_gallbladder_physiolo2.78948126
8MP0000003_abnormal_adipose_tissue2.60066318
9MP0005375_adipose_tissue_phenotype2.44994967
10MP0010329_abnormal_lipoprotein_level2.29706595
11MP0009115_abnormal_fat_cell2.28699219
12MP0004885_abnormal_endolymph2.28085956
13MP0008058_abnormal_DNA_repair2.27194128
14MP0004130_abnormal_muscle_cell2.24066280
15MP0001502_abnormal_circadian_rhythm2.18399410
16MP0005666_abnormal_adipose_tissue2.07014264
17MP0005167_abnormal_blood-brain_barrier2.06454180
18MP0010368_abnormal_lymphatic_system2.06425699
19MP0002909_abnormal_adrenal_gland2.05612812
20MP0003690_abnormal_glial_cell2.04673389
21MP0001501_abnormal_sleep_pattern1.98804356
22MP0002971_abnormal_brown_adipose1.87659218
23MP0004742_abnormal_vestibular_system1.47344462
24MP0003880_abnormal_central_pattern1.46414465
25MP0003959_abnormal_lean_body1.45125749
26MP0005334_abnormal_fat_pad1.42530588
27MP0003879_abnormal_hair_cell1.38368896
28MP0005448_abnormal_energy_balance1.37603511
29MP0002970_abnormal_white_adipose1.35270226
30MP0010030_abnormal_orbit_morphology1.34511913
31MP0000230_abnormal_systemic_arterial1.30828569
32MP0005367_renal/urinary_system_phenotyp1.27560652
33MP0000516_abnormal_urinary_system1.27560652
34MP0004036_abnormal_muscle_relaxation1.26668715
35MP0000569_abnormal_digit_pigmentation1.24063601
36MP0001879_abnormal_lymphatic_vessel1.18206438
37MP0004859_abnormal_synaptic_plasticity1.17804692
38MP0002272_abnormal_nervous_system1.16894619
39MP0009745_abnormal_behavioral_response1.16022653
40MP0008872_abnormal_physiological_respon1.15723880
41MP0003329_amyloid_beta_deposits1.15251635
42MP0003123_paternal_imprinting1.13941741
43MP0002064_seizures1.13566572
44MP0003195_calcinosis1.09839298
45MP0005275_abnormal_skin_tensile1.08969335
46MP0003635_abnormal_synaptic_transmissio1.08873263
47MP0002118_abnormal_lipid_homeostasis1.08340761
48MP0008057_abnormal_DNA_replication1.08200986
49MP0004145_abnormal_muscle_electrophysio1.08160053
50MP0005551_abnormal_eye_electrophysiolog1.04671520
51MP0008875_abnormal_xenobiotic_pharmacok0.98135312
52MP0009643_abnormal_urine_homeostasis0.94251002
53MP0002572_abnormal_emotion/affect_behav0.94088132
54MP0005423_abnormal_somatic_nervous0.93008600
55MP0001486_abnormal_startle_reflex0.92813845
56MP0010386_abnormal_urinary_bladder0.90865806
57MP0005595_abnormal_vascular_smooth0.90174781
58MP0006138_congestive_heart_failure0.89874374
59MP0004019_abnormal_vitamin_homeostasis0.85797095
60MP0004270_analgesia0.84430262
61MP0002063_abnormal_learning/memory/cond0.83233500
62MP0005266_abnormal_metabolism0.82288515
63MP0000343_altered_response_to0.82164546
64MP0004084_abnormal_cardiac_muscle0.82036223
65MP0005452_abnormal_adipose_tissue0.79205518
66MP0004215_abnormal_myocardial_fiber0.78240116
67MP0005620_abnormal_muscle_contractility0.77282603
68MP0005503_abnormal_tendon_morphology0.77026200
69MP0009780_abnormal_chondrocyte_physiolo0.76400672
70MP0001984_abnormal_olfaction0.75255963
71MP0003633_abnormal_nervous_system0.73512138
72MP0004142_abnormal_muscle_tone0.72921102
73MP0008569_lethality_at_weaning0.72676904
74MP0000604_amyloidosis0.70981635
75MP0002127_abnormal_cardiovascular_syste0.70745492
76MP0003011_delayed_dark_adaptation0.69614678
77MP0002067_abnormal_sensory_capabilities0.69150740
78MP0000026_abnormal_inner_ear0.67206316
79MP0005174_abnormal_tail_pigmentation0.66910064
80MP0003828_pulmonary_edema0.66878667
81MP0005386_behavior/neurological_phenoty0.66722155
82MP0004924_abnormal_behavior0.66722155
83MP0002108_abnormal_muscle_morphology0.66526793
84MP0002069_abnormal_eating/drinking_beha0.66493339
85MP0005646_abnormal_pituitary_gland0.65118629
86MP0000538_abnormal_urinary_bladder0.63237606
87MP0003638_abnormal_response/metabolism_0.62712791
88MP0001905_abnormal_dopamine_level0.62682450
89MP0002078_abnormal_glucose_homeostasis0.62531644
90MP0006276_abnormal_autonomic_nervous0.61713634
91MP0000249_abnormal_blood_vessel0.60711247
92MP0005164_abnormal_response_to0.60654881
93MP0008877_abnormal_DNA_methylation0.58727008
94MP0003632_abnormal_nervous_system0.57817268
95MP0003631_nervous_system_phenotype0.57799425
96MP0008874_decreased_physiological_sensi0.56416369
97MP0001963_abnormal_hearing_physiology0.56111253
98MP0003718_maternal_effect0.50832194
99MP0002734_abnormal_mechanical_nocicepti0.50669529
100MP0009046_muscle_twitch0.50455366

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)4.55227832
2Abnormality of binocular vision (HP:0011514)4.04228863
3Diplopia (HP:0000651)4.04228863
4Tubulointerstitial fibrosis (HP:0005576)3.79839762
5Fair hair (HP:0002286)3.75975279
6Hypokalemic alkalosis (HP:0001949)3.72935805
7Generalized hyperpigmentation (HP:0007440)3.67502588
8Abnormality of chloride homeostasis (HP:0011422)3.55136076
9Abnormality of the prostate (HP:0008775)3.46596458
10Back pain (HP:0003418)3.34743074
11Anterior segment dysgenesis (HP:0007700)3.32017650
12Psychosis (HP:0000709)3.30911872
13Mesangial abnormality (HP:0001966)3.27355667
14Hyperaldosteronism (HP:0000859)3.21977645
15Neurofibrillary tangles (HP:0002185)3.21075864
16Protruding tongue (HP:0010808)3.18883503
17Epidermoid cyst (HP:0200040)3.18203420
18Clumsiness (HP:0002312)3.13594717
19Generalized hypopigmentation of hair (HP:0011358)3.09470656
20Hyperlipoproteinemia (HP:0010980)3.09066007
21Torticollis (HP:0000473)3.02593705
22Tubulointerstitial abnormality (HP:0001969)3.00107025
23Polyuria (HP:0000103)2.96714618
24Renal salt wasting (HP:0000127)2.94392878
25Genetic anticipation (HP:0003743)2.93620231
26Retinal atrophy (HP:0001105)2.87573758
27Porencephaly (HP:0002132)2.86499621
28Absent speech (HP:0001344)2.76157422
29Cutaneous photosensitivity (HP:0000992)2.75834815
30Abnormal urine output (HP:0012590)2.64957740
31Exertional dyspnea (HP:0002875)2.64047863
32Increased muscle lipid content (HP:0009058)2.59973605
33Muscle fiber splitting (HP:0003555)2.58268177
34Progressive cerebellar ataxia (HP:0002073)2.56845014
35Bilateral microphthalmos (HP:0007633)2.56127803
36Tubular atrophy (HP:0000092)2.55660208
37Abnormality of the renal cortex (HP:0011035)2.50921634
38Broad-based gait (HP:0002136)2.49334365
39Spastic tetraparesis (HP:0001285)2.47470671
40Papillary thyroid carcinoma (HP:0002895)2.42136585
41Hyperventilation (HP:0002883)2.39667590
42Increased intramyocellular lipid droplets (HP:0012240)2.39426684
43Absent hand (HP:0004050)2.39395066
44Dysmetric saccades (HP:0000641)2.39334207
45Conical tooth (HP:0000698)2.36083338
46Hyperkalemia (HP:0002153)2.35659831
47Onycholysis (HP:0001806)2.32311020
48Abnormality of the axillary hair (HP:0100134)2.31134134
49Abnormality of secondary sexual hair (HP:0009888)2.31134134
50Malnutrition (HP:0004395)2.28159217
51Abnormality of potassium homeostasis (HP:0011042)2.28146271
52Periorbital edema (HP:0100539)2.25039502
53Xanthomatosis (HP:0000991)2.24585400
54Asymmetric septal hypertrophy (HP:0001670)2.22432554
55Large for gestational age (HP:0001520)2.21430969
56Abnormality of renal excretion (HP:0011036)2.19653495
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.18159280
58Increased hepatocellular lipid droplets (HP:0006565)2.15464070
59Facial edema (HP:0000282)2.14047778
60Blue irides (HP:0000635)2.11319879
61Hypokalemia (HP:0002900)2.11308414
62Aplasia involving bones of the extremities (HP:0009825)2.07056416
63Aplasia involving bones of the upper limbs (HP:0009823)2.07056416
64Aplasia of the phalanges of the hand (HP:0009802)2.07056416
65Alkalosis (HP:0001948)2.06159566
66Febrile seizures (HP:0002373)2.05577251
67Ureteral stenosis (HP:0000071)2.03082251
68Diminished motivation (HP:0000745)2.02973363
69Abnormality of male internal genitalia (HP:0000022)1.98706933
70Abnormality of sodium homeostasis (HP:0010931)1.97846350
71Skin nodule (HP:0200036)1.97637147
72Heart block (HP:0012722)1.97501453
73Cerebral inclusion bodies (HP:0100314)1.97355919
74Renal Fanconi syndrome (HP:0001994)1.96151395
75Craniofacial dystonia (HP:0012179)1.94123695
76Renal cell carcinoma (HP:0005584)1.92970626
77Adrenal overactivity (HP:0002717)1.92599283
78Hyponatremia (HP:0002902)1.90745032
79Thin skin (HP:0000963)1.89557369
80Focal dystonia (HP:0004373)1.89424361
81Hemiplegia (HP:0002301)1.89255838
82Acanthosis nigricans (HP:0000956)1.88094036
83Hypotrichosis (HP:0001006)1.87234281
84Postural instability (HP:0002172)1.85204956
85Prostate neoplasm (HP:0100787)1.84959681
86Ureteral obstruction (HP:0006000)1.84668769
87Palpebral edema (HP:0100540)1.84469267
88Type 1 muscle fiber predominance (HP:0003803)1.81940201
89Adactyly (HP:0009776)1.81904757
90Chest pain (HP:0100749)1.80738984
91Limb dystonia (HP:0002451)1.80472106
92Bundle branch block (HP:0011710)1.80283200
93Type II lissencephaly (HP:0007260)1.79032885
94Bronchomalacia (HP:0002780)1.78458943
95Death in childhood (HP:0003819)1.78153884
96Abnormal atrioventricular conduction (HP:0005150)1.76592717
97Lipid accumulation in hepatocytes (HP:0006561)1.76180472
98Dry hair (HP:0011359)1.75657380
99Progressive microcephaly (HP:0000253)1.75404126
100Congenital, generalized hypertrichosis (HP:0004540)1.75386089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB17.95794192
2NEK27.19033435
3CAMKK25.32766245
4CAMK1D4.44808916
5CAMK1G2.91704849
6TAF12.49699497
7CAMKK12.30341858
8SMG12.27882863
9ERN12.21456447
10VRK22.08579991
11CAMK12.02630978
12LRRK21.71885438
13MAP3K71.66461563
14CHUK1.55947473
15MAPKAPK51.44095884
16GRK51.39124067
17MARK21.30704140
18TESK11.30432374
19TESK21.29279294
20WNK41.28369712
21MARK11.22504548
22NTRK31.15884128
23PHKG20.98159737
24PHKG10.98159737
25PNCK0.97556966
26MAPK150.97329026
27OBSCN0.95538728
28MAPK40.95239335
29PRKAA20.91547274
30TRIB30.90247858
31MAP3K40.88224391
32MAPK70.85269718
33STK240.82961408
34ABL20.82404145
35CAMK40.82364380
36LIMK10.78406254
37CASK0.77467513
38PDGFRB0.74444378
39NUAK10.72457070
40DAPK20.69964448
41MAP3K100.68099662
42GRK10.65374884
43TIE10.63418363
44MAPK120.63294955
45PAK20.63193754
46PKN10.55091518
47DYRK1A0.52004875
48HIPK20.49822522
49FRK0.48590654
50VRK10.45633454
51PRKG10.45225354
52PRKD10.44779350
53NTRK20.44701578
54CSK0.43057324
55PINK10.42424928
56PRKAA10.40870892
57MELK0.40039359
58MAP2K40.38559953
59PRKCG0.38338760
60CAMK2B0.38063207
61DDR20.36472954
62DAPK10.32655966
63EIF2AK20.31918966
64PRKCE0.31650195
65LATS20.30944271
66EPHA40.30092559
67MAPK130.28795288
68CAMK2A0.28786818
69RIPK10.28460816
70PAK30.28172149
71CDK90.28125736
72ADRBK10.27376689
73SGK20.26638770
74PRKCH0.26431525
75PAK60.25455354
76CDK50.22805805
77TTN0.22722339
78WNK10.22707882
79SGK10.21663853
80PRPF4B0.21438945
81SYK0.21366215
82ACVR1B0.20857509
83DAPK30.20715445
84TYRO30.20558238
85STK38L0.20383022
86IKBKE0.20274359
87PRKD30.19993933
88MAP2K70.19532551
89MYLK0.19494969
90PIK3CG0.19402672
91PRKCA0.18762059
92PRKACA0.18049886
93MAPK100.17331274
94PRKCI0.17000417
95KSR20.15856525
96SIK20.15764267
97CAMK2D0.14974085
98TGFBR10.14098709
99PTK2B0.13491467
100PIK3CA0.13117942

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003403.26660623
2Renin-angiotensin system_Homo sapiens_hsa046142.94968710
3Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.83782102
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.67075096
5Caffeine metabolism_Homo sapiens_hsa002322.57604461
6Nicotine addiction_Homo sapiens_hsa050332.38193504
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.30181338
8Synaptic vesicle cycle_Homo sapiens_hsa047211.90234692
9Ovarian steroidogenesis_Homo sapiens_hsa049131.89671062
10PPAR signaling pathway_Homo sapiens_hsa033201.78430556
11Glutamatergic synapse_Homo sapiens_hsa047241.76695432
12Tryptophan metabolism_Homo sapiens_hsa003801.74820366
13Pyruvate metabolism_Homo sapiens_hsa006201.72264502
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71166948
15beta-Alanine metabolism_Homo sapiens_hsa004101.63876205
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63110570
17Glycerolipid metabolism_Homo sapiens_hsa005611.58592903
18Circadian entrainment_Homo sapiens_hsa047131.56552929
19Phenylalanine metabolism_Homo sapiens_hsa003601.56120392
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54539525
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49879846
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.49195944
23Morphine addiction_Homo sapiens_hsa050321.45225568
24GABAergic synapse_Homo sapiens_hsa047271.43284742
25Taste transduction_Homo sapiens_hsa047421.41044799
26Renin secretion_Homo sapiens_hsa049241.40549409
27Phototransduction_Homo sapiens_hsa047441.38185928
28Cardiac muscle contraction_Homo sapiens_hsa042601.31061242
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.27611466
30Cocaine addiction_Homo sapiens_hsa050301.19914210
31Calcium signaling pathway_Homo sapiens_hsa040201.19793501
32Oxytocin signaling pathway_Homo sapiens_hsa049211.15342553
33Linoleic acid metabolism_Homo sapiens_hsa005911.11333871
34Dilated cardiomyopathy_Homo sapiens_hsa054141.11112141
35Long-term depression_Homo sapiens_hsa047301.10928190
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10780350
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06792988
38Salivary secretion_Homo sapiens_hsa049701.04058946
39Nitrogen metabolism_Homo sapiens_hsa009101.03814471
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03386831
41Fatty acid degradation_Homo sapiens_hsa000711.00284143
42Olfactory transduction_Homo sapiens_hsa047400.99284382
43Propanoate metabolism_Homo sapiens_hsa006400.99204816
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98494084
45Arginine and proline metabolism_Homo sapiens_hsa003300.97394928
46Insulin secretion_Homo sapiens_hsa049110.96984582
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93833905
48cAMP signaling pathway_Homo sapiens_hsa040240.93112373
49Phagosome_Homo sapiens_hsa041450.90094857
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89970295
51Gastric acid secretion_Homo sapiens_hsa049710.89743960
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86541691
53Pancreatic secretion_Homo sapiens_hsa049720.83405827
54AMPK signaling pathway_Homo sapiens_hsa041520.81337670
55ECM-receptor interaction_Homo sapiens_hsa045120.80094834
56Serotonergic synapse_Homo sapiens_hsa047260.79914518
57Axon guidance_Homo sapiens_hsa043600.78754758
58Cholinergic synapse_Homo sapiens_hsa047250.78301891
59Gap junction_Homo sapiens_hsa045400.76698321
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.73629223
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72989099
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71739128
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.69460948
64ABC transporters_Homo sapiens_hsa020100.68420004
65Lysosome_Homo sapiens_hsa041420.67250346
66Basal transcription factors_Homo sapiens_hsa030220.66945292
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66213862
68Amphetamine addiction_Homo sapiens_hsa050310.65429822
69Lysine degradation_Homo sapiens_hsa003100.65103168
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64486725
71Ether lipid metabolism_Homo sapiens_hsa005650.64485661
72ErbB signaling pathway_Homo sapiens_hsa040120.63844084
73Starch and sucrose metabolism_Homo sapiens_hsa005000.63818286
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62353750
75Bile secretion_Homo sapiens_hsa049760.62128955
76Dopaminergic synapse_Homo sapiens_hsa047280.62083011
77Chemical carcinogenesis_Homo sapiens_hsa052040.59256020
78Staphylococcus aureus infection_Homo sapiens_hsa051500.57141529
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56839261
80Retinol metabolism_Homo sapiens_hsa008300.56182830
81Amoebiasis_Homo sapiens_hsa051460.55898599
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.55012938
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54789435
84Tyrosine metabolism_Homo sapiens_hsa003500.51537664
85Hedgehog signaling pathway_Homo sapiens_hsa043400.47121883
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46722923
87Fat digestion and absorption_Homo sapiens_hsa049750.46656531
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44629902
89Complement and coagulation cascades_Homo sapiens_hsa046100.44201629
90Type II diabetes mellitus_Homo sapiens_hsa049300.43496915
91Melanogenesis_Homo sapiens_hsa049160.43434869
92Protein digestion and absorption_Homo sapiens_hsa049740.43414440
93Dorso-ventral axis formation_Homo sapiens_hsa043200.41724638
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40835941
95Vibrio cholerae infection_Homo sapiens_hsa051100.40775997
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40721375
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38078220
98Circadian rhythm_Homo sapiens_hsa047100.37439880
99Platelet activation_Homo sapiens_hsa046110.37023740
100Ras signaling pathway_Homo sapiens_hsa040140.36600339

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