RER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)4.38399037
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.38399037
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.37765571
4L-phenylalanine catabolic process (GO:0006559)4.31043450
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.31043450
6cysteine metabolic process (GO:0006534)4.15862059
7barbed-end actin filament capping (GO:0051016)4.11609632
8serine family amino acid biosynthetic process (GO:0009070)3.88141505
9protein localization to endosome (GO:0036010)3.75898777
10aldehyde catabolic process (GO:0046185)3.74649934
11skin morphogenesis (GO:0043589)3.65359457
12viral transcription (GO:0019083)3.61192879
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58312827
14glyoxylate metabolic process (GO:0046487)3.57204385
15aromatic amino acid family catabolic process (GO:0009074)3.56861651
16cotranslational protein targeting to membrane (GO:0006613)3.55064510
17translational termination (GO:0006415)3.54556749
18protein targeting to ER (GO:0045047)3.53873353
19L-serine metabolic process (GO:0006563)3.53490466
20protein maturation by protein folding (GO:0022417)3.45049149
21serine family amino acid metabolic process (GO:0009069)3.44431361
22protein localization to endoplasmic reticulum (GO:0070972)3.42559895
23sulfur amino acid catabolic process (GO:0000098)3.39897484
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35880763
25NADH metabolic process (GO:0006734)3.34220046
26glycine metabolic process (GO:0006544)3.30147155
27pinocytosis (GO:0006907)3.23854167
28response to nitrosative stress (GO:0051409)3.21800353
29ribosomal small subunit assembly (GO:0000028)3.14486547
30negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.13523848
31bile acid biosynthetic process (GO:0006699)3.11680630
32GDP-mannose metabolic process (GO:0019673)3.10978604
33* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10796553
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10032931
35lysine metabolic process (GO:0006553)3.08084081
36lysine catabolic process (GO:0006554)3.08084081
37glycosphingolipid catabolic process (GO:0046479)3.07880856
38ethanol oxidation (GO:0006069)3.07579846
39valine metabolic process (GO:0006573)3.06625285
40translational elongation (GO:0006414)3.03969979
41signal peptide processing (GO:0006465)3.03789945
42ribosomal small subunit biogenesis (GO:0042274)3.03403847
43alpha-linolenic acid metabolic process (GO:0036109)3.02610118
44triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.99071474
45peptidyl-glutamic acid carboxylation (GO:0017187)2.98190999
46protein carboxylation (GO:0018214)2.98190999
47positive regulation of Cdc42 GTPase activity (GO:0043089)2.97850450
48antigen processing and presentation of endogenous antigen (GO:0019883)2.96433787
49tryptophan catabolic process (GO:0006569)2.93000004
50indole-containing compound catabolic process (GO:0042436)2.93000004
51indolalkylamine catabolic process (GO:0046218)2.93000004
52homocysteine metabolic process (GO:0050667)2.92194038
53serine family amino acid catabolic process (GO:0009071)2.89291424
54glycolipid catabolic process (GO:0019377)2.84140257
55L-methionine biosynthetic process (GO:0071265)2.83709497
56amino acid salvage (GO:0043102)2.83709497
57L-methionine salvage (GO:0071267)2.83709497
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82684634
59basement membrane organization (GO:0071711)2.81886738
60negative regulation of fibrinolysis (GO:0051918)2.81174181
61kynurenine metabolic process (GO:0070189)2.80704718
62viral life cycle (GO:0019058)2.80472878
63drug transmembrane transport (GO:0006855)2.78584676
64proline biosynthetic process (GO:0006561)2.76877362
65aromatic amino acid family metabolic process (GO:0009072)2.74836749
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74122416
67tryptophan metabolic process (GO:0006568)2.72000819
68ethanol metabolic process (GO:0006067)2.71770208
69NIK/NF-kappaB signaling (GO:0038061)2.70268773
70fatty acid elongation (GO:0030497)2.69498793
71proteasome assembly (GO:0043248)2.68346688
72regulation of protein activation cascade (GO:2000257)2.68288985
73fibril organization (GO:0097435)2.67343578
74acetyl-CoA metabolic process (GO:0006084)2.67066171
75pentose-phosphate shunt (GO:0006098)2.66500981
76heme transport (GO:0015886)2.66220160
77regulation of early endosome to late endosome transport (GO:2000641)2.65158013
78urea cycle (GO:0000050)2.64926948
79regulation of necrotic cell death (GO:0010939)2.64701077
80urate metabolic process (GO:0046415)2.64696596
81NADPH regeneration (GO:0006740)2.64213418
82branched-chain amino acid catabolic process (GO:0009083)2.63666103
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.62830040
84regulation of triglyceride catabolic process (GO:0010896)2.62518966
85translational initiation (GO:0006413)2.62027766
86stress fiber assembly (GO:0043149)2.61855571
87fatty acid beta-oxidation (GO:0006635)2.61581649
88regulation of fibrinolysis (GO:0051917)2.60707445
89regulation of superoxide anion generation (GO:0032928)2.60230178
90branched-chain amino acid metabolic process (GO:0009081)2.59874344
91regulation of complement activation (GO:0030449)2.59320363
92cellular protein complex disassembly (GO:0043624)2.59239557
93cellular aldehyde metabolic process (GO:0006081)2.58692826
94xenobiotic catabolic process (GO:0042178)2.58329190
95bile acid metabolic process (GO:0008206)2.58269035
96cellular copper ion homeostasis (GO:0006878)2.58082413
97cofactor catabolic process (GO:0051187)2.58005939
98amino-acid betaine metabolic process (GO:0006577)2.57985380
99regulation of extracellular matrix disassembly (GO:0010715)2.57857243
100hyaluronan catabolic process (GO:0030214)2.57630892
101activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.57400617
102NADP metabolic process (GO:0006739)2.57297775
103cellular glucuronidation (GO:0052695)2.56604117
104mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.55503677
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.54775017
106urea metabolic process (GO:0019627)2.54517119
107cellular modified amino acid catabolic process (GO:0042219)2.54411282
108plasma lipoprotein particle clearance (GO:0034381)2.54239288
109DNA deamination (GO:0045006)2.54179993
110glutathione derivative metabolic process (GO:1901685)2.52851352
111glutathione derivative biosynthetic process (GO:1901687)2.52851352
112alpha-amino acid catabolic process (GO:1901606)2.52706632
113cellular ketone body metabolic process (GO:0046950)2.51775770
114peptidyl-proline hydroxylation (GO:0019511)2.51771031
115positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51510947
116folic acid metabolic process (GO:0046655)2.51088414
117sulfur amino acid biosynthetic process (GO:0000097)2.51005992
118complement activation, alternative pathway (GO:0006957)2.51004916
119uronic acid metabolic process (GO:0006063)2.50960181
120glucuronate metabolic process (GO:0019585)2.50960181
121fatty acid catabolic process (GO:0009062)2.50148795
122fatty acid oxidation (GO:0019395)2.49989024
123protein retention in ER lumen (GO:0006621)2.49844316
124fibrinolysis (GO:0042730)2.49674977
125regulation of cholesterol metabolic process (GO:0090181)2.49208810
126nitrogen cycle metabolic process (GO:0071941)2.48900666
127primary alcohol catabolic process (GO:0034310)2.48643413
128endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.48402032
129drug transport (GO:0015893)2.48383708
130adhesion of symbiont to host (GO:0044406)2.48260673
131COPI coating of Golgi vesicle (GO:0048205)2.48216984
132Golgi transport vesicle coating (GO:0048200)2.48216984
133translation (GO:0006412)2.48115271
134high-density lipoprotein particle remodeling (GO:0034375)2.48078565
135hypotonic response (GO:0006971)2.47881351
136antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.47546850
137positive regulation of nuclease activity (GO:0032075)2.47279307
138apoptotic cell clearance (GO:0043277)2.45980258
139positive regulation of extracellular matrix organization (GO:1903055)2.45942512
140virion attachment to host cell (GO:0019062)2.45288003
141adhesion of symbiont to host cell (GO:0044650)2.45288003
142extracellular fibril organization (GO:0043206)2.43827131
143positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43647102
144negative regulation of protein localization to plasma membrane (GO:1903077)2.43080627
145regulation of metalloenzyme activity (GO:0048552)2.42753424
146protein hydroxylation (GO:0018126)2.42435511
147positive regulation of receptor recycling (GO:0001921)2.42019953
148membrane raft organization (GO:0031579)2.41759081
149glucose catabolic process (GO:0006007)2.41364277
150endoplasmic reticulum unfolded protein response (GO:0030968)2.40495107
151nucleoside diphosphate biosynthetic process (GO:0009133)2.39857775
152negative regulation of necroptotic process (GO:0060546)2.39845509
153regulation of type I interferon-mediated signaling pathway (GO:0060338)2.38923519
154cell adhesion mediated by integrin (GO:0033627)2.35387784
155response to laminar fluid shear stress (GO:0034616)2.34161128
156negative regulation of cell killing (GO:0031342)2.33378544
157negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.33378544
158mannose metabolic process (GO:0006013)2.32391619
159regulation of defense response to virus by virus (GO:0050690)2.31116738
160vesicle coating (GO:0006901)2.30526725
161regulation of necroptotic process (GO:0060544)2.27756371
162cell-substrate junction assembly (GO:0007044)2.27566156
163regulation of nuclease activity (GO:0032069)2.26433185
164negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.24703513
165negative regulation of erythrocyte differentiation (GO:0045647)2.24600836
166response to thyroid hormone (GO:0097066)2.23849434
167epithelial cell differentiation involved in prostate gland development (GO:0060742)2.23316303
168peptide catabolic process (GO:0043171)2.21689899
169ER-nucleus signaling pathway (GO:0006984)2.21535029
170hemidesmosome assembly (GO:0031581)2.20740855
171Arp2/3 complex-mediated actin nucleation (GO:0034314)2.20145874
172angiotensin maturation (GO:0002003)2.20096404
173positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.19623142
174membrane protein ectodomain proteolysis (GO:0006509)2.19492816
175cellular response to unfolded protein (GO:0034620)2.19337146
176endodermal cell differentiation (GO:0035987)2.18546842
177nucleobase-containing small molecule interconversion (GO:0015949)2.18095547
178positive regulation of pseudopodium assembly (GO:0031274)2.17907350
179tricarboxylic acid metabolic process (GO:0072350)2.15983164
180type B pancreatic cell proliferation (GO:0044342)2.15542484
181glucose 6-phosphate metabolic process (GO:0051156)2.15037409
182ceramide catabolic process (GO:0046514)2.14578110
183amyloid precursor protein catabolic process (GO:0042987)2.13852129
184regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.13595320
185UV protection (GO:0009650)2.12641977
186adherens junction assembly (GO:0034333)2.12302405
187negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.12063231
188actin filament depolymerization (GO:0030042)2.10388187
189positive regulation of triglyceride lipase activity (GO:0061365)2.10031806
190positive regulation of lipoprotein lipase activity (GO:0051006)2.10031806
191cell-substrate adherens junction assembly (GO:0007045)2.10029484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.21486975
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.84821712
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.44088329
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.43118153
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25130974
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.19345072
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.99289896
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85589944
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84939658
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.71647243
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.63612708
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.47140206
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.38943291
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.38886094
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33443501
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32027769
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30517311
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28486209
19VDR_21846776_ChIP-Seq_THP-1_Human2.21728788
20LXR_22292898_ChIP-Seq_THP-1_Human2.19120300
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14480731
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.07379065
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05855589
24* ETS1_20019798_ChIP-Seq_JURKAT_Human2.00856512
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00730786
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.00323481
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99664581
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95644168
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93401919
30RACK7_27058665_Chip-Seq_MCF-7_Human1.90572622
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86259358
32CLOCK_20551151_ChIP-Seq_293T_Human1.81755516
33DCP1A_22483619_ChIP-Seq_HELA_Human1.78774217
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78343219
35MYC_22102868_ChIP-Seq_BL_Human1.75571105
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71783542
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.67697603
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65603449
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64083873
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63128322
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.62932328
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61768920
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.61626868
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60559359
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60087297
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57219401
47AR_21909140_ChIP-Seq_LNCAP_Human1.56707556
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.56570548
49* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55076052
50* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54886383
51VDR_23849224_ChIP-Seq_CD4+_Human1.54709960
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53420049
53* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52103061
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50498986
55XRN2_22483619_ChIP-Seq_HELA_Human1.49886398
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49135914
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44512679
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.44374005
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44311189
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43488950
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42722215
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41366256
63VDR_24763502_ChIP-Seq_THP-1_Human1.41271473
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38109766
65* MAF_26560356_Chip-Seq_TH1_Human1.37512283
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37472202
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37085649
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35508345
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35079093
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.34806650
71TCF7_22412390_ChIP-Seq_EML_Mouse1.34729048
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30887702
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.30682581
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30559153
75GABP_19822575_ChIP-Seq_HepG2_Human1.29744292
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29464818
77KDM2B_26808549_Chip-Seq_DND41_Human1.28326707
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27737581
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25906337
80* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25135054
81* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25090430
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24044706
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23929800
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23771337
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21864733
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20992661
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20786817
88NCOR1_26117541_ChIP-Seq_K562_Human1.18817317
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.18754744
90* SA1_27219007_Chip-Seq_ERYTHROID_Human1.17952061
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17916564
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17841114
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16420770
94* MAF_26560356_Chip-Seq_TH2_Human1.16190467
95ELK1_19687146_ChIP-ChIP_HELA_Human1.16172402
96* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16149219
97* UTX_26944678_Chip-Seq_JUKART_Human1.16031417
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15550555
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15494064
100E2F7_22180533_ChIP-Seq_HELA_Human1.15425262
101ZNF263_19887448_ChIP-Seq_K562_Human1.13981192
102FOXP3_21729870_ChIP-Seq_TREG_Human1.12664464
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11873795
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10862487
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09842992
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09739479
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08574892
108ESR2_21235772_ChIP-Seq_MCF-7_Human1.07690296
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07489966
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04690872
111GATA1_22025678_ChIP-Seq_K562_Human1.03584542
112* P68_20966046_ChIP-Seq_HELA_Human1.03065450
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02550831
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02322823
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.01541426
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01084188
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00894597
118BCOR_27268052_Chip-Seq_Bcells_Human1.00121771
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99702337
120FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99468709
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99261613
122SMC4_20622854_ChIP-Seq_HELA_Human0.98062931
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97781100
124TFEB_21752829_ChIP-Seq_HELA_Human0.97675536
125* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97219501
126* SPI1_23547873_ChIP-Seq_NB4_Human0.97174398
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.96884379
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96589784
129TTF2_22483619_ChIP-Seq_HELA_Human0.96086592
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95123490
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93014221
132GATA4_25053715_ChIP-Seq_YYC3_Human0.92943616
133IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92665607
134* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92312661
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91584082
136SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91326047
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90229921
138RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90156270
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88633638
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87458092
141CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87414178
142* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82912608
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81774842
144ATF3_27146783_Chip-Seq_COLON_Human0.81676055
145TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81204200
146SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79421260
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.78565342
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78221730
149TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78087338
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.77925174
151CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77896595
152MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.77721275
153HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.77502307
154* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77477166
155SOX2_20726797_ChIP-Seq_SW620_Human0.76856843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.66380309
2MP0005360_urolithiasis4.54558381
3MP0003806_abnormal_nucleotide_metabolis4.07141203
4MP0005085_abnormal_gallbladder_physiolo3.28165133
5MP0005365_abnormal_bile_salt3.16381889
6MP0008875_abnormal_xenobiotic_pharmacok2.81625711
7MP0002877_abnormal_melanocyte_morpholog2.76886080
8MP0009840_abnormal_foam_cell2.61805338
9MP0008260_abnormal_autophagy2.45223277
10MP0001666_abnormal_nutrient_absorption2.36668707
11MP0003186_abnormal_redox_activity2.34549988
12MP0003566_abnormal_cell_adhesion2.34084599
13MP0008438_abnormal_cutaneous_collagen2.23597055
14MP0005332_abnormal_amino_acid2.23440077
15MP0003195_calcinosis2.14610084
16MP0005083_abnormal_biliary_tract2.09436980
17MP0004858_abnormal_nervous_system1.94306410
18MP0003252_abnormal_bile_duct1.84612471
19MP0010329_abnormal_lipoprotein_level1.79693553
20MP0003279_aneurysm1.76809760
21MP0003724_increased_susceptibility_to1.72926188
22MP0005058_abnormal_lysosome_morphology1.72023332
23MP0009643_abnormal_urine_homeostasis1.70785373
24MP0003191_abnormal_cellular_cholesterol1.70602169
25MP0006054_spinal_hemorrhage1.68928243
26MP0009379_abnormal_foot_pigmentation1.66097219
27MP0004019_abnormal_vitamin_homeostasis1.62792189
28MP0003656_abnormal_erythrocyte_physiolo1.56392846
29MP0005257_abnormal_intraocular_pressure1.55611211
30MP0003011_delayed_dark_adaptation1.54911858
31MP0003303_peritoneal_inflammation1.53618604
32MP0003091_abnormal_cell_migration1.47502549
33MP0001849_ear_inflammation1.47457388
34MP0000609_abnormal_liver_physiology1.47375219
35MP0003705_abnormal_hypodermis_morpholog1.45982764
36MP0003436_decreased_susceptibility_to1.43685225
37MP0001764_abnormal_homeostasis1.42636473
38MP0005451_abnormal_body_composition1.41777984
39MP0005319_abnormal_enzyme/_coenzyme1.41342112
40MP0005275_abnormal_skin_tensile1.40993708
41MP0002138_abnormal_hepatobiliary_system1.36582521
42MP0002118_abnormal_lipid_homeostasis1.32237672
43MP0005636_abnormal_mineral_homeostasis1.29595027
44MP0006036_abnormal_mitochondrial_physio1.23147740
45MP0005584_abnormal_enzyme/coenzyme_acti1.22523204
46MP0009384_cardiac_valve_regurgitation1.21940522
47MP0003448_altered_tumor_morphology1.21193033
48MP0003075_altered_response_to1.20674007
49MP0005408_hypopigmentation1.20493520
50MP0002796_impaired_skin_barrier1.18587782
51MP0008469_abnormal_protein_level1.18544777
52MP0003172_abnormal_lysosome_physiology1.18372385
53MP0005084_abnormal_gallbladder_morpholo1.17540332
54MP0003329_amyloid_beta_deposits1.17095810
55MP0003763_abnormal_thymus_physiology1.16936331
56MP0009785_altered_susceptibility_to1.16692525
57MP0002998_abnormal_bone_remodeling1.16571497
58MP0010352_gastrointestinal_tract_polyps1.13566970
59MP0005623_abnormal_meninges_morphology1.12384380
60MP0005220_abnormal_exocrine_pancreas1.11829061
61MP0001756_abnormal_urination1.11442410
62MP0010234_abnormal_vibrissa_follicle1.11052088
63MP0003693_abnormal_embryo_hatching1.10979984
64MP0001542_abnormal_bone_strength1.10233583
65MP0009333_abnormal_splenocyte_physiolog1.07758524
66MP0001853_heart_inflammation1.07681635
67MP0001533_abnormal_skeleton_physiology1.05508910
68MP0002132_abnormal_respiratory_system1.05308659
69MP0003300_gastrointestinal_ulcer1.04740939
70MP0004147_increased_porphyrin_level1.04199421
71MP0005387_immune_system_phenotype1.03433479
72MP0001790_abnormal_immune_system1.03433479
73MP0002060_abnormal_skin_morphology1.01800842
74MP0006082_CNS_inflammation1.00883659
75MP0003718_maternal_effect1.00330106
76MP0005166_decreased_susceptibility_to0.98828228
77MP0000678_abnormal_parathyroid_gland0.98591964
78MP0005023_abnormal_wound_healing0.98105770
79MP0002166_altered_tumor_susceptibility0.97464750
80MP0000598_abnormal_liver_morphology0.97231438
81MP0000685_abnormal_immune_system0.96244168
82MP0000751_myopathy0.96232947
83MP0002136_abnormal_kidney_physiology0.95697263
84MP0001958_emphysema0.95560425
85MP0009763_increased_sensitivity_to0.95184086
86MP0005076_abnormal_cell_differentiation0.94997581
87MP0001873_stomach_inflammation0.94578443
88MP0005025_abnormal_response_to0.94252939
89MP0005501_abnormal_skin_physiology0.94171902
90MP0001835_abnormal_antigen_presentation0.94110748
91MP0001243_abnormal_dermal_layer0.93508161
92MP0004233_abnormal_muscle_weight0.92161580
93MP0001845_abnormal_inflammatory_respons0.90483516
94MP0005164_abnormal_response_to0.90173668
95MP0002452_abnormal_antigen_presenting0.88771839
96MP0010155_abnormal_intestine_physiology0.88708657
97MP0000465_gastrointestinal_hemorrhage0.88292184
98MP0004264_abnormal_extraembryonic_tissu0.87359965
99MP0005390_skeleton_phenotype0.87138464
100MP0000747_muscle_weakness0.86991307
101MP0001819_abnormal_immune_cell0.86701403
102MP0004947_skin_inflammation0.86663392
103MP0005503_abnormal_tendon_morphology0.86273476
104MP0002420_abnormal_adaptive_immunity0.85939100
105MP0009278_abnormal_bone_marrow0.85803103
106MP0010368_abnormal_lymphatic_system0.85707684
107MP0002723_abnormal_immune_serum0.85598468
108MP0009764_decreased_sensitivity_to0.85435284
109MP0005666_abnormal_adipose_tissue0.85397853
110MP0002896_abnormal_bone_mineralization0.84518035
111MP0004510_myositis0.84149130
112MP0005621_abnormal_cell_physiology0.83218508
113MP0001661_extended_life_span0.82971180
114MP0004957_abnormal_blastocyst_morpholog0.82905104
115MP0003795_abnormal_bone_structure0.82458783
116MP0003868_abnormal_feces_composition0.81846579
117MP0003828_pulmonary_edema0.80204339
118MP0002419_abnormal_innate_immunity0.78128558
119MP0001915_intracranial_hemorrhage0.76771057
120MP0009931_abnormal_skin_appearance0.75964922
121MP0004185_abnormal_adipocyte_glucose0.75610541
122MP0005330_cardiomyopathy0.75386002
123MP0000604_amyloidosis0.74818574
124MP0001216_abnormal_epidermal_layer0.74756853
125MP0002933_joint_inflammation0.74735979
126MP0005375_adipose_tissue_phenotype0.74181150
127MP0003950_abnormal_plasma_membrane0.74168720
128MP0005000_abnormal_immune_tolerance0.73806558
129MP0000003_abnormal_adipose_tissue0.73671823
130MP0001800_abnormal_humoral_immune0.73618067
131MP0001851_eye_inflammation0.73617485
132MP0002148_abnormal_hypersensitivity_rea0.73290093
133MP0005409_darkened_coat_color0.73161072
134MP0000490_abnormal_crypts_of0.72370929
135MP0000343_altered_response_to0.71992709
136MP0000858_altered_metastatic_potential0.71946734
137MP0004043_abnormal_pH_regulation0.71176440
138MP0009765_abnormal_xenobiotic_induced0.71094150
139MP0003453_abnormal_keratinocyte_physiol0.69884752
140MP0008004_abnormal_stomach_pH0.69553124
141MP0004782_abnormal_surfactant_physiolog0.68428201
142MP0000377_abnormal_hair_follicle0.67917083
143MP0001881_abnormal_mammary_gland0.67328557
144MP0009642_abnormal_blood_homeostasis0.65698305
145MP0005464_abnormal_platelet_physiology0.65601985
146MP0004272_abnormal_basement_membrane0.65496462
147MP0005376_homeostasis/metabolism_phenot0.65401425
148MP0005165_increased_susceptibility_to0.64554020
149MP0005395_other_phenotype0.63839762

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.47887650
2Protrusio acetabuli (HP:0003179)4.23708113
3Vertebral compression fractures (HP:0002953)4.01869508
4Intrahepatic cholestasis (HP:0001406)3.80368734
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.72896061
6Xanthomatosis (HP:0000991)3.69644654
7Hypobetalipoproteinemia (HP:0003563)3.30669064
8Abnormality of glycolipid metabolism (HP:0010969)3.22606743
9Abnormality of liposaccharide metabolism (HP:0010968)3.22606743
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.22606743
11Deep venous thrombosis (HP:0002625)3.20846464
12Hyperglycinuria (HP:0003108)3.18146100
13Abnormality of glycine metabolism (HP:0010895)3.09863626
14Abnormality of serine family amino acid metabolism (HP:0010894)3.09863626
15Hyperammonemia (HP:0001987)3.06521266
16Abnormality of fatty-acid metabolism (HP:0004359)2.94997788
17Hepatic necrosis (HP:0002605)2.93335691
18Vacuolated lymphocytes (HP:0001922)2.90001859
19Hyperlipoproteinemia (HP:0010980)2.89920185
20Hyperglycinemia (HP:0002154)2.87773900
21Fat malabsorption (HP:0002630)2.85273731
22Hypoglycemic coma (HP:0001325)2.84625852
23Atrophic scars (HP:0001075)2.80749064
24Generalized aminoaciduria (HP:0002909)2.79780366
25Prolonged partial thromboplastin time (HP:0003645)2.72309912
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.71295631
27Abnormality of glycolysis (HP:0004366)2.69917928
28Increased serum pyruvate (HP:0003542)2.69917928
29Eczematoid dermatitis (HP:0000976)2.68077025
30Increased connective tissue (HP:0009025)2.67374829
31Dicarboxylic aciduria (HP:0003215)2.66068312
32Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66068312
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62853481
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62347700
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62347700
36Abnormality of the common coagulation pathway (HP:0010990)2.62104755
37Steatorrhea (HP:0002570)2.61278951
38Distal lower limb muscle weakness (HP:0009053)2.53787808
39Hepatocellular necrosis (HP:0001404)2.53510703
40Achilles tendon contracture (HP:0001771)2.53371256
41Fragile skin (HP:0001030)2.49129144
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.48334789
43Osteolytic defects of the hand bones (HP:0009699)2.48334789
44Abnormality of the intrinsic pathway (HP:0010989)2.47233385
45Cerebral edema (HP:0002181)2.46788974
46Lethargy (HP:0001254)2.46674725
47Acute encephalopathy (HP:0006846)2.44653130
48Ketosis (HP:0001946)2.44343307
49Glycosuria (HP:0003076)2.44244082
50Abnormality of urine glucose concentration (HP:0011016)2.44244082
51Abnormality of cells of the erythroid lineage (HP:0012130)2.41585625
52Hypolipoproteinemia (HP:0010981)2.40281304
53Distal lower limb amyotrophy (HP:0008944)2.39696064
54Dilatation of the ascending aorta (HP:0005111)2.38800993
55Dysostosis multiplex (HP:0000943)2.36759606
56Abnormality of the Achilles tendon (HP:0005109)2.36280649
57Abnormality of serum amino acid levels (HP:0003112)2.34706188
58Complement deficiency (HP:0004431)2.33750016
59Cervical subluxation (HP:0003308)2.33623179
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33151929
61Increased muscle lipid content (HP:0009058)2.32719954
62Abnormal number of erythroid precursors (HP:0012131)2.32385261
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.31999410
64Gout (HP:0001997)2.31999398
65Multiple enchondromatosis (HP:0005701)2.31619730
66Distal upper limb amyotrophy (HP:0007149)2.31479983
67Upper limb amyotrophy (HP:0009129)2.31479983
68Vascular tortuosity (HP:0004948)2.31302654
69Abnormality of sulfur amino acid metabolism (HP:0004339)2.30676396
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.30534522
71Abnormality of methionine metabolism (HP:0010901)2.28259019
72Wormian bones (HP:0002645)2.28218571
73Abnormal cartilage morphology (HP:0002763)2.27904572
74Macrocytic anemia (HP:0001972)2.27681807
75Cerebral aneurysm (HP:0004944)2.27258320
76Abnormality of purine metabolism (HP:0004352)2.27071726
77Abnormal hemoglobin (HP:0011902)2.26776729
78Proximal tubulopathy (HP:0000114)2.26339517
79Aortic dissection (HP:0002647)2.26035894
80Hemorrhage of the eye (HP:0011885)2.22776832
81Peritonitis (HP:0002586)2.22099537
82Blue sclerae (HP:0000592)2.21747651
83Abnormality of macrophages (HP:0004311)2.20776309
84Premature rupture of membranes (HP:0001788)2.20542522
85Amyloidosis (HP:0011034)2.19248467
86Increased intramyocellular lipid droplets (HP:0012240)2.18659003
87Ankle contracture (HP:0006466)2.17729256
88Abnormality of nucleobase metabolism (HP:0010932)2.16001827
89Beaking of vertebral bodies (HP:0004568)2.15641381
90Hyperbilirubinemia (HP:0002904)2.15420007
91Interstitial pulmonary disease (HP:0006530)2.13621912
92Mitochondrial inheritance (HP:0001427)2.13371030
93Abnormal gallbladder physiology (HP:0012438)2.12592616
94Cholecystitis (HP:0001082)2.12592616
95Lipid accumulation in hepatocytes (HP:0006561)2.11890847
96Mildly elevated creatine phosphokinase (HP:0008180)2.11858237
97Arterial tortuosity (HP:0005116)2.11317805
98Axonal loss (HP:0003447)2.10984111
99Reticulocytopenia (HP:0001896)2.10434417
100Purpura (HP:0000979)2.10200401
101Abnormality of the distal phalanges of the toes (HP:0010182)2.10066891
102Vascular calcification (HP:0004934)2.10002976
103Bladder diverticulum (HP:0000015)2.08954506
104Nonimmune hydrops fetalis (HP:0001790)2.07529999
105Ileus (HP:0002595)2.07167857
106Elbow flexion contracture (HP:0002987)2.05139687
107Cardiovascular calcification (HP:0011915)2.04706596
108Delayed CNS myelination (HP:0002188)2.04404495
109Conjugated hyperbilirubinemia (HP:0002908)2.03214956
110Malnutrition (HP:0004395)2.03123444
111Vomiting (HP:0002013)2.02963910
112Spinal rigidity (HP:0003306)2.02311086
113Short nail (HP:0001799)2.01833108
114Abnormal mitochondria in muscle tissue (HP:0008316)2.01403490
115Metabolic acidosis (HP:0001942)2.01046793
116Trismus (HP:0000211)1.98720295
117Abnormality of skeletal muscle fiber size (HP:0012084)1.97574073
118Acute necrotizing encephalopathy (HP:0006965)1.97439059
119Increased serum ferritin (HP:0003281)1.97269534
120Abnormality of complement system (HP:0005339)1.96579836
1213-Methylglutaconic aciduria (HP:0003535)1.96006804
122Increased CSF lactate (HP:0002490)1.94432558
123Joint hemorrhage (HP:0005261)1.94341440
124Pancreatitis (HP:0001733)1.94244662
125Nausea (HP:0002018)1.94179799
126Abnormality of pyrimidine metabolism (HP:0004353)1.93862029
127Urinary glycosaminoglycan excretion (HP:0003541)1.93065896
128Mucopolysacchariduria (HP:0008155)1.93065896
129Abnormality of transition element cation homeostasis (HP:0011030)1.92899472
130Hypertensive crisis (HP:0100735)1.92031260
131Elevated erythrocyte sedimentation rate (HP:0003565)1.91763295
132Systemic lupus erythematosus (HP:0002725)1.91383905
133Loss of speech (HP:0002371)1.91346939
134Ketoacidosis (HP:0001993)1.91001156
135Abnormality of iron homeostasis (HP:0011031)1.90659830
136Biconcave vertebral bodies (HP:0004586)1.90638794
137Lactic acidosis (HP:0003128)1.90330919
138Abnormality of polysaccharide metabolism (HP:0011012)1.90232421
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90232421
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90232421
141Increased variability in muscle fiber diameter (HP:0003557)1.89986887
142Poor head control (HP:0002421)1.89934446
143Hypoalphalipoproteinemia (HP:0003233)1.87924567
144Reduced subcutaneous adipose tissue (HP:0003758)1.87801041
145Aortic aneurysm (HP:0004942)1.87699612
146Ragged-red muscle fibers (HP:0003200)1.86645690
147CNS demyelination (HP:0007305)1.86414919
148Cellulitis (HP:0100658)1.86254300
149Polycythemia (HP:0001901)1.84953874
150Increased hepatocellular lipid droplets (HP:0006565)1.83760506
151Hepatosplenomegaly (HP:0001433)1.83360602
152Generalized amyotrophy (HP:0003700)1.83243283
153Renal Fanconi syndrome (HP:0001994)1.82924894
154Myocardial infarction (HP:0001658)1.82658990
155Opisthotonus (HP:0002179)1.82343772
156Congenital ichthyosiform erythroderma (HP:0007431)1.82211283
157Increased serum lactate (HP:0002151)1.82136222
158Aneurysm (HP:0002617)1.81945321
159Genu recurvatum (HP:0002816)1.81833232
160Recurrent abscess formation (HP:0002722)1.81818991
161Bone pain (HP:0002653)1.81415064
162Hyperacusis (HP:0010780)1.81241585
163Hand muscle atrophy (HP:0009130)1.80545369
164Nuclear cataract (HP:0100018)1.79373283
165Thin bony cortex (HP:0002753)1.78434154
166Reduced antithrombin III activity (HP:0001976)1.78319016
167Hyperphosphaturia (HP:0003109)1.78261178
168Epidermoid cyst (HP:0200040)1.74947823
169Abnormal delivery (HP:0001787)1.74250264
170Back pain (HP:0003418)1.73657319
171Mitral stenosis (HP:0001718)1.73125342
172Disproportionate tall stature (HP:0001519)1.72370276
173Mitral regurgitation (HP:0001653)1.72250644
174Ulnar bowing (HP:0003031)1.70993737
175Abnormality of the nasal mucosa (HP:0000433)1.70680759
176Hypertriglyceridemia (HP:0002155)1.70404720
177Abnormality of the acetabulum (HP:0003170)1.70266029
178Flat acetabular roof (HP:0003180)1.70172438
179Petechiae (HP:0000967)1.68225828
180Chronic obstructive pulmonary disease (HP:0006510)1.67436299
181Obstructive lung disease (HP:0006536)1.67436299
182Spondylolisthesis (HP:0003302)1.67019292
183Neurofibrillary tangles (HP:0002185)1.66270822
184Breech presentation (HP:0001623)1.65505788
185Hyperparathyroidism (HP:0000843)1.64960927
186Cerebral inclusion bodies (HP:0100314)1.64801314
187Type 1 muscle fiber predominance (HP:0003803)1.64763885
188Soft skin (HP:0000977)1.62030963
189Polygenic inheritance (HP:0010982)1.61720104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.17934735
2BCKDK3.63281508
3EIF2AK12.76135643
4PRPF4B2.75112660
5BUB12.51666883
6TESK22.39795347
7PBK2.37759098
8TLK12.35801536
9SMG12.29138646
10ERN12.28842882
11KDR2.26755082
12PIM22.19042704
13STK162.14262461
14RIPK12.14198434
15TESK11.89885335
16LIMK11.77124548
17RPS6KA41.75005174
18TAOK21.70343607
19MST41.67791844
20LRRK21.67395778
21MST1R1.66133726
22TRIB31.65413005
23MAP3K111.63894012
24SCYL21.63631191
25EPHB11.59316541
26EIF2AK31.55105746
27TYK21.55004339
28FGFR41.54876470
29PDGFRA1.53335159
30IRAK31.51016089
31STK391.48790022
32MAP3K31.46044921
33NTRK11.45152895
34MAP3K131.42553238
35WEE11.39599870
36NEK91.39453315
37MAP4K11.39450246
38TBK11.29369731
39ARAF1.17492626
40BLK1.16530519
41PTK21.15988185
42PIK3CG1.15549900
43KSR21.15110402
44ICK1.14873702
45MOS1.14818554
46ACVR1B1.14015659
47STK101.12320034
48CDK121.06152649
49ABL21.05432648
50OXSR11.05426752
51ILK1.01565146
52EPHA20.97767942
53MAP2K20.96859312
54ZAP700.94010751
55MAP3K120.93869595
56WNK40.92571509
57MYLK0.92165462
58RIPK40.91185684
59LMTK20.90892288
60MET0.90551815
61MAPKAPK30.90291752
62DDR20.89943304
63TEC0.87176080
64PRKD20.86623691
65DYRK30.86616229
66MAP3K10.85289479
67EEF2K0.83824897
68MAP3K80.82970905
69PKN20.79791579
70NME10.77940177
71PAK40.77298740
72BRSK20.77229018
73JAK10.76960882
74TGFBR20.76628854
75RPS6KB20.76289383
76PDPK10.74942250
77CDC42BPA0.74806050
78MAPKAPK50.74736274
79MAP2K30.73421397
80LATS20.71738363
81EPHB20.70522932
82RPS6KA50.67422722
83IKBKE0.67374321
84TAOK10.66603690
85MAP3K60.65763341
86CDK60.65062338
87BMX0.64639873
88MAPK110.64563361
89PAK20.63502704
90JAK30.62961744
91SIK30.62712762
92PTK60.62432630
93SIK10.62311888
94IRAK10.61831144
95FLT30.61520223
96NUAK10.59130636
97BTK0.58586639
98MAP3K20.58369990
99FRK0.57850705
100AURKB0.57197844
101EPHA30.57016576
102PRKG20.55724433
103CSK0.54998254
104TTN0.54715494
105MAP3K140.53732462
106ITK0.53450467
107CSNK1G30.52599576
108IRAK40.52384505
109KIT0.52005389
110PIM10.50037702
111IKBKB0.49890357
112CSF1R0.49789397
113DYRK1B0.49340333
114TXK0.49015594
115VRK10.48931571
116TGFBR10.48775744
117BCR0.48556985
118ROCK20.48162409
119PAK10.47811628
120PDK20.47538616
121AURKA0.47124710
122MAP3K100.47050465
123STK380.45519232
124MAPKAPK20.45141109
125CLK10.45031832
126MTOR0.44920536
127BRAF0.44173886
128NLK0.43445615
129SRPK10.42451817
130CSNK1G10.40142904
131JAK20.39648866
132DAPK10.38596817
133NEK10.38197223
134CAMK2G0.37745679
135TAOK30.37530968
136PRKCI0.37453826
137TIE10.36178220
138HCK0.35152475
139STK38L0.35051875
140RAF10.35038612
141RET0.34838904
142CDK40.34678997
143DAPK30.33695037
144MAPK40.33370036
145GRK60.33137611

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.63214613
2Ribosome_Homo sapiens_hsa030102.50549315
3Folate biosynthesis_Homo sapiens_hsa007902.46957398
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.42151168
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33675381
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29142197
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15097931
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15072722
9Protein export_Homo sapiens_hsa030602.15011474
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.08069448
11Proteasome_Homo sapiens_hsa030502.06737400
12Fatty acid degradation_Homo sapiens_hsa000712.02316888
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95661344
14Sulfur metabolism_Homo sapiens_hsa009201.92684305
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86671682
16Fatty acid elongation_Homo sapiens_hsa000621.84231536
17Propanoate metabolism_Homo sapiens_hsa006401.80922926
18Peroxisome_Homo sapiens_hsa041461.80787169
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80359274
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.76215204
21Sulfur relay system_Homo sapiens_hsa041221.72009548
22Steroid biosynthesis_Homo sapiens_hsa001001.65849432
23Tryptophan metabolism_Homo sapiens_hsa003801.64951435
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64003720
25Glutathione metabolism_Homo sapiens_hsa004801.61517683
26Prion diseases_Homo sapiens_hsa050201.60924592
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60694246
28Shigellosis_Homo sapiens_hsa051311.59392993
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57394334
30Nitrogen metabolism_Homo sapiens_hsa009101.56600114
31Histidine metabolism_Homo sapiens_hsa003401.56541297
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52684846
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52507323
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.49737185
35Caffeine metabolism_Homo sapiens_hsa002321.49041763
36Chemical carcinogenesis_Homo sapiens_hsa052041.46484521
37Bladder cancer_Homo sapiens_hsa052191.42899141
38Chronic myeloid leukemia_Homo sapiens_hsa052201.40636805
39Complement and coagulation cascades_Homo sapiens_hsa046101.40003818
40Butanoate metabolism_Homo sapiens_hsa006501.38626835
41Fatty acid metabolism_Homo sapiens_hsa012121.36806189
42Acute myeloid leukemia_Homo sapiens_hsa052211.36360964
43Selenocompound metabolism_Homo sapiens_hsa004501.36041769
44Vibrio cholerae infection_Homo sapiens_hsa051101.33705089
45Pyruvate metabolism_Homo sapiens_hsa006201.32335328
46Arginine biosynthesis_Homo sapiens_hsa002201.31042809
47Oxidative phosphorylation_Homo sapiens_hsa001901.30833954
48beta-Alanine metabolism_Homo sapiens_hsa004101.30000913
49Carbon metabolism_Homo sapiens_hsa012001.27831587
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.26587580
51Pancreatic cancer_Homo sapiens_hsa052121.26470524
52Pentose phosphate pathway_Homo sapiens_hsa000301.26258075
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25381340
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24756482
55Osteoclast differentiation_Homo sapiens_hsa043801.23132198
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22226779
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.22046950
58Arginine and proline metabolism_Homo sapiens_hsa003301.21993710
59Fat digestion and absorption_Homo sapiens_hsa049751.20918930
60Leishmaniasis_Homo sapiens_hsa051401.20168066
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.19323463
62Retinol metabolism_Homo sapiens_hsa008301.18399746
63PPAR signaling pathway_Homo sapiens_hsa033201.18148539
64Staphylococcus aureus infection_Homo sapiens_hsa051501.14726545
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.14662949
66Salmonella infection_Homo sapiens_hsa051321.14519450
67Vitamin B6 metabolism_Homo sapiens_hsa007501.13557433
68Toxoplasmosis_Homo sapiens_hsa051451.11237231
69Steroid hormone biosynthesis_Homo sapiens_hsa001401.10965045
70Amoebiasis_Homo sapiens_hsa051461.08472406
71Biosynthesis of amino acids_Homo sapiens_hsa012301.07642391
72Parkinsons disease_Homo sapiens_hsa050121.07583612
73Apoptosis_Homo sapiens_hsa042101.06553286
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06545874
75Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06327956
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05674838
77Viral myocarditis_Homo sapiens_hsa054161.05017249
78Hepatitis C_Homo sapiens_hsa051601.04868881
79Vitamin digestion and absorption_Homo sapiens_hsa049771.04513167
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04068851
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02510040
82Phagosome_Homo sapiens_hsa041451.01484411
83Focal adhesion_Homo sapiens_hsa045100.99687605
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99486445
85Thyroid cancer_Homo sapiens_hsa052160.98666945
86Pertussis_Homo sapiens_hsa051330.97147839
87DNA replication_Homo sapiens_hsa030300.95219150
88Pyrimidine metabolism_Homo sapiens_hsa002400.93924854
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93003168
90One carbon pool by folate_Homo sapiens_hsa006700.90165164
91B cell receptor signaling pathway_Homo sapiens_hsa046620.89978170
92Starch and sucrose metabolism_Homo sapiens_hsa005000.88852349
93Small cell lung cancer_Homo sapiens_hsa052220.88818020
94Endocytosis_Homo sapiens_hsa041440.88234313
95Phenylalanine metabolism_Homo sapiens_hsa003600.88008520
96Tuberculosis_Homo sapiens_hsa051520.86796117
97Influenza A_Homo sapiens_hsa051640.85994055
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.85593692
99Malaria_Homo sapiens_hsa051440.84514105
100Non-small cell lung cancer_Homo sapiens_hsa052230.82108260
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.81987026
102RNA polymerase_Homo sapiens_hsa030200.80806837
103TNF signaling pathway_Homo sapiens_hsa046680.80760628
104Metabolic pathways_Homo sapiens_hsa011000.80473471
105Tyrosine metabolism_Homo sapiens_hsa003500.79939997
106VEGF signaling pathway_Homo sapiens_hsa043700.78338509
107ECM-receptor interaction_Homo sapiens_hsa045120.77056986
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77032733
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75891965
110Proteoglycans in cancer_Homo sapiens_hsa052050.75792578
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72960815
112Renal cell carcinoma_Homo sapiens_hsa052110.70362991
113Hepatitis B_Homo sapiens_hsa051610.68814744
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66856317
115Herpes simplex infection_Homo sapiens_hsa051680.65863898
116Other glycan degradation_Homo sapiens_hsa005110.64631559
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62584881
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61157354
119Measles_Homo sapiens_hsa051620.60669956
120Allograft rejection_Homo sapiens_hsa053300.59000950
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.58236180
122Alzheimers disease_Homo sapiens_hsa050100.57927139
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57660213
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57414351
125Linoleic acid metabolism_Homo sapiens_hsa005910.55477806
126Autoimmune thyroid disease_Homo sapiens_hsa053200.54847884
127HTLV-I infection_Homo sapiens_hsa051660.54790699
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54749000
129Epstein-Barr virus infection_Homo sapiens_hsa051690.54632312
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54374280
131Insulin signaling pathway_Homo sapiens_hsa049100.54356400
132Arachidonic acid metabolism_Homo sapiens_hsa005900.54355025
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.53823924
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52909244
135Lysosome_Homo sapiens_hsa041420.52295665
136Galactose metabolism_Homo sapiens_hsa000520.51671772
137N-Glycan biosynthesis_Homo sapiens_hsa005100.51431785
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51396675
139Glycerolipid metabolism_Homo sapiens_hsa005610.51291490
140Huntingtons disease_Homo sapiens_hsa050160.50670084
141HIF-1 signaling pathway_Homo sapiens_hsa040660.50134293
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48400197
143Hematopoietic cell lineage_Homo sapiens_hsa046400.47630489
144Graft-versus-host disease_Homo sapiens_hsa053320.47161268
145Viral carcinogenesis_Homo sapiens_hsa052030.45693179
146Bile secretion_Homo sapiens_hsa049760.45411958
147Antigen processing and presentation_Homo sapiens_hsa046120.43847270
148Mismatch repair_Homo sapiens_hsa034300.43746070
149Notch signaling pathway_Homo sapiens_hsa043300.42656083
150Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42265408
151Renin-angiotensin system_Homo sapiens_hsa046140.42047769
152Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41559616
153Fructose and mannose metabolism_Homo sapiens_hsa000510.40268683
154Base excision repair_Homo sapiens_hsa034100.38944421
155Homologous recombination_Homo sapiens_hsa034400.38561835
156ABC transporters_Homo sapiens_hsa020100.36604638
157Protein digestion and absorption_Homo sapiens_hsa049740.36136607
158Nucleotide excision repair_Homo sapiens_hsa034200.36032292
159Legionellosis_Homo sapiens_hsa051340.35093115
160Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33440569
161Sphingolipid metabolism_Homo sapiens_hsa006000.33243491
162Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31896053

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