REG3G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycolipid catabolic process (GO:0019377)8.31108139
2L-ascorbic acid metabolic process (GO:0019852)7.84715945
3renal absorption (GO:0070293)7.79576687
4one-carbon compound transport (GO:0019755)7.65874313
5phosphatidylinositol acyl-chain remodeling (GO:0036149)7.34219841
6membrane lipid catabolic process (GO:0046466)7.29127666
7phosphatidylserine acyl-chain remodeling (GO:0036150)7.15228392
8phosphatidylglycerol acyl-chain remodeling (GO:0036148)7.04263119
9xenobiotic catabolic process (GO:0042178)6.90852840
10icosanoid secretion (GO:0032309)6.90259505
11arachidonic acid secretion (GO:0050482)6.90259505
12neutrophil mediated immunity (GO:0002446)6.86783952
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.32522870
14protein retention in ER lumen (GO:0006621)6.04888818
15glutathione derivative biosynthetic process (GO:1901687)5.89286096
16glutathione derivative metabolic process (GO:1901685)5.89286096
17icosanoid transport (GO:0071715)5.86844822
18fatty acid derivative transport (GO:1901571)5.86844822
19ceramide catabolic process (GO:0046514)5.72236012
20polyketide metabolic process (GO:0030638)5.70889176
21doxorubicin metabolic process (GO:0044598)5.70889176
22daunorubicin metabolic process (GO:0044597)5.70889176
23regulation of skeletal muscle contraction (GO:0014819)5.59746290
24tetrapyrrole metabolic process (GO:0033013)5.48444538
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.45791783
26peptidyl-proline hydroxylation (GO:0019511)5.29483255
27negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)5.22394103
28bundle of His cell to Purkinje myocyte communication (GO:0086069)5.18121481
29leukotriene biosynthetic process (GO:0019370)5.12826226
30aminoglycoside antibiotic metabolic process (GO:0030647)5.12432180
31lung lobe morphogenesis (GO:0060463)5.11193683
32surfactant homeostasis (GO:0043129)5.08577438
33phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.05093738
34myeloid leukocyte mediated immunity (GO:0002444)4.95025482
35gas transport (GO:0015669)4.92984179
36antibacterial humoral response (GO:0019731)4.92278044
37intestinal epithelial cell development (GO:0060576)4.87986330
38antimicrobial humoral response (GO:0019730)4.85110204
39detection of other organism (GO:0098543)4.70631593
40regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.68429295
41regulation of guanylate cyclase activity (GO:0031282)4.68323970
42phosphatidylserine metabolic process (GO:0006658)4.65007093
43phosphatidylcholine acyl-chain remodeling (GO:0036151)4.61703088
44interferon-gamma secretion (GO:0072643)4.58748810
45retinol metabolic process (GO:0042572)4.58694038
46retinoic acid metabolic process (GO:0042573)4.44361472
47negative regulation of humoral immune response (GO:0002921)4.42627722
48negative regulation of complement activation (GO:0045916)4.42376886
49cholesterol catabolic process (GO:0006707)4.41664327
50sterol catabolic process (GO:0016127)4.41664327
51leukotriene metabolic process (GO:0006691)4.37281820
52response to nitrosative stress (GO:0051409)4.36801483
53multicellular organismal water homeostasis (GO:0050891)4.36671847
54phosphatidic acid metabolic process (GO:0046473)4.28398901
55phosphatidic acid biosynthetic process (GO:0006654)4.28398901
56regulation of cellular extravasation (GO:0002691)4.24406398
57O-glycan processing (GO:0016266)4.23936991
58sphingolipid catabolic process (GO:0030149)4.21963247
59detection of bacterium (GO:0016045)4.20081905
60regulation of triglyceride catabolic process (GO:0010896)4.14964176
61cellular response to arsenic-containing substance (GO:0071243)4.13695648
62water-soluble vitamin metabolic process (GO:0006767)4.13566379
63cardiovascular system development (GO:0072358)4.09020856
64positive regulation of guanylate cyclase activity (GO:0031284)4.07520023
65cellular protein catabolic process (GO:0044257)4.06475982
66vitamin transmembrane transport (GO:0035461)4.06404182
67protein hydroxylation (GO:0018126)4.03920998
68epithelial cell differentiation involved in prostate gland development (GO:0060742)3.95213157
69chemical homeostasis within a tissue (GO:0048875)3.95147123
70alditol phosphate metabolic process (GO:0052646)3.94589230
71flavonoid metabolic process (GO:0009812)3.88352172
72sterol transport (GO:0015918)3.81617782
73cholesterol transport (GO:0030301)3.81617782
74sulfur amino acid catabolic process (GO:0000098)3.78567633
75positive regulation of osteoblast proliferation (GO:0033690)3.76335231
76negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.76144419
77maintenance of gastrointestinal epithelium (GO:0030277)3.75724584
78water homeostasis (GO:0030104)3.74664812
79cellular response to cadmium ion (GO:0071276)3.73702084
80hemidesmosome assembly (GO:0031581)3.70565859
81negative regulation of protein activation cascade (GO:2000258)3.69681326
82primary alcohol metabolic process (GO:0034308)3.69507688
83angiotensin maturation (GO:0002003)3.66807805
84phospholipid catabolic process (GO:0009395)3.64053571
85regulation of cholesterol homeostasis (GO:2000188)3.62568349
86glycoside metabolic process (GO:0016137)3.53331293
87nucleotide-sugar biosynthetic process (GO:0009226)3.51200192
88* negative regulation of epidermal cell differentiation (GO:0045605)3.49334213
89cellular response to zinc ion (GO:0071294)3.48830135
90hormone catabolic process (GO:0042447)3.41646322
91regulation of acrosome reaction (GO:0060046)3.40117776
92vitamin metabolic process (GO:0006766)3.39734032
93extracellular regulation of signal transduction (GO:1900115)3.38842285
94extracellular negative regulation of signal transduction (GO:1900116)3.38842285
95intestinal cholesterol absorption (GO:0030299)3.37089247
96positive regulation of steroid biosynthetic process (GO:0010893)3.29385888
97phosphatidylglycerol metabolic process (GO:0046471)3.28507122
98toxin metabolic process (GO:0009404)3.28306676
99positive regulation of pseudopodium assembly (GO:0031274)3.27064461
100face development (GO:0060324)3.26178678
101regulation of secondary heart field cardioblast proliferation (GO:0003266)3.25192487
102regulation of cardioblast proliferation (GO:0003264)3.25192487
103regulation of female gonad development (GO:2000194)3.23286236
104retinoid metabolic process (GO:0001523)3.19808864
105regulation of bile acid biosynthetic process (GO:0070857)3.17775493
106branching involved in labyrinthine layer morphogenesis (GO:0060670)3.17413182
107desmosome organization (GO:0002934)3.17195678
108regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.16896800
109xenobiotic metabolic process (GO:0006805)3.14944398
110cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.14507268
111multicellular organismal catabolic process (GO:0044243)3.12976716
112peptide catabolic process (GO:0043171)3.10899763
113regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.09846810
114glandular epithelial cell differentiation (GO:0002067)3.09610574
115calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.09001839
116positive regulation of hormone biosynthetic process (GO:0046886)3.05904394
117aldehyde catabolic process (GO:0046185)3.04904590
118cellular aldehyde metabolic process (GO:0006081)3.04177692
119positive regulation of blood coagulation (GO:0030194)3.04125269
120positive regulation of hemostasis (GO:1900048)3.04125269
121digestive system process (GO:0022600)3.02662938
122progesterone metabolic process (GO:0042448)3.00681076
123diterpenoid metabolic process (GO:0016101)3.00038254
124excretion (GO:0007588)2.99519373
125hydrogen peroxide catabolic process (GO:0042744)2.98239261
126regulation of steroid hormone biosynthetic process (GO:0090030)2.97510862
127nitric oxide biosynthetic process (GO:0006809)2.96631113
128positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.95475055
129activation of MAPKKK activity (GO:0000185)2.95467812
130positive regulation of coagulation (GO:0050820)2.94324425
131cellular glucuronidation (GO:0052695)2.93061865
132cyclooxygenase pathway (GO:0019371)2.92915617
133regulation of pseudopodium assembly (GO:0031272)2.92808020
134multicellular organismal metabolic process (GO:0044236)2.92017516
135fatty acid derivative biosynthetic process (GO:1901570)2.91368871
136icosanoid biosynthetic process (GO:0046456)2.91368871
137endothelial cell migration (GO:0043542)2.91157297
138epithelial structure maintenance (GO:0010669)2.91112894
139glucuronate metabolic process (GO:0019585)2.90867717
140uronic acid metabolic process (GO:0006063)2.90867717
141transepithelial transport (GO:0070633)2.90430547
142positive regulation of respiratory burst (GO:0060267)2.88600454
143mucosal immune response (GO:0002385)2.86424915
144NADH metabolic process (GO:0006734)2.86119706
145ventricular cardiac muscle cell action potential (GO:0086005)2.86078475
146negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.85360403
147positive regulation of vesicle fusion (GO:0031340)2.85236527
148mitochondrial calcium ion transport (GO:0006851)2.84995778
149regulation of cholesterol biosynthetic process (GO:0045540)2.84842715
150positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.84724849
151positive regulation of digestive system process (GO:0060456)2.82446612
152regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.80667763
153regulation of cGMP biosynthetic process (GO:0030826)2.79887564
154regulation of vitamin metabolic process (GO:0030656)2.79854440
155regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.79129735
156cellular copper ion homeostasis (GO:0006878)2.78772464
157intestinal absorption (GO:0050892)2.77164536
158organ or tissue specific immune response (GO:0002251)2.74856914
159bile acid and bile salt transport (GO:0015721)2.74625495
160long-chain fatty acid transport (GO:0015909)2.73860891
161valine metabolic process (GO:0006573)2.73651805
162regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.73023789
163positive regulation of steroid metabolic process (GO:0045940)2.72672110
164hepatocyte apoptotic process (GO:0097284)2.72251326
165glutathione metabolic process (GO:0006749)2.72211497
166innate immune response in mucosa (GO:0002227)2.66768656
167regulation of hormone biosynthetic process (GO:0046885)2.66422221
168terpenoid metabolic process (GO:0006721)2.66017358
169phototransduction, visible light (GO:0007603)2.62745193
170regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.60319909
171extracellular matrix disassembly (GO:0022617)2.54238846
172positive regulation of triglyceride metabolic process (GO:0090208)2.53691578
173icosanoid metabolic process (GO:0006690)2.53080289
174fatty acid derivative metabolic process (GO:1901568)2.53080289
175negative regulation of hormone metabolic process (GO:0032351)2.44570001
176digestion (GO:0007586)16.8354832
177cobalamin metabolic process (GO:0009235)16.4303275
178ethanol oxidation (GO:0006069)13.0340506
179transcytosis (GO:0045056)10.9111249
180ethanol metabolic process (GO:0006067)10.2255113
181primary alcohol catabolic process (GO:0034310)10.2102466
182regulation of phospholipase A2 activity (GO:0032429)10.1283715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.20741545
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.90665643
3TRIM28_21343339_ChIP-Seq_HEK293_Human5.21360241
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.75544989
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.28694789
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.05767115
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.03280279
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.03280279
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.03280279
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.01952895
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.88106090
12EGR1_19032775_ChIP-ChIP_M12_Human2.86278123
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.80409211
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.72051817
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.71588920
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60544587
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44867217
18SOX2_20726797_ChIP-Seq_SW620_Human2.35304815
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28473811
20PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.27323343
21CDX2_20551321_ChIP-Seq_CACO-2_Human2.25640964
22ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10252421
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09105709
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.06075546
25ZNF263_19887448_ChIP-Seq_K562_Human2.05910920
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.03523044
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.03181712
28GATA4_25053715_ChIP-Seq_YYC3_Human1.94304063
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.84777589
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84204808
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80761212
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.80636190
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.77886456
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76806782
35* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74611958
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.69614561
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67643326
38AHR_22903824_ChIP-Seq_MCF-7_Human1.67617737
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64854481
40FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.62955503
41GATA6_25053715_ChIP-Seq_YYC3_Human1.62488999
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62383117
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61217858
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61217858
45HTT_18923047_ChIP-ChIP_STHdh_Human1.61155398
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60922045
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.55891923
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50532670
49GATA1_22025678_ChIP-Seq_K562_Human1.49718705
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48755788
51KLF5_25053715_ChIP-Seq_YYC3_Human1.48461622
52CLOCK_20551151_ChIP-Seq_293T_Human1.47947699
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.47613206
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.47543083
55HNFA_21074721_ChIP-Seq_CACO-2_Human1.46180569
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45121896
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45121896
58FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42047574
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40298140
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37585880
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.37182036
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36299659
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36184223
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.35904021
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33671556
66NFYA_21822215_ChIP-Seq_K562_Human1.31777752
67PHF8_20622853_ChIP-Seq_HELA_Human1.31765391
68GATA6_21074721_ChIP-Seq_CACO-2_Human1.31122377
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30299125
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28710866
71RBPJ_21746931_ChIP-Seq_IB4_Human1.28147860
72TP53_18474530_ChIP-ChIP_U2OS_Human1.27510867
73RACK7_27058665_Chip-Seq_MCF-7_Human1.26969151
74FOXA1_25552417_ChIP-Seq_VCAP_Human1.26040919
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.20616715
76* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.19289475
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19062896
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18725221
79* ETV1_20927104_ChIP-Seq_GIST48_Human1.17730994
80* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17285175
81* TCF4_18268006_ChIP-ChIP_LS174T_Human1.14880475
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.10873689
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.10587105
84ESET_19884257_ChIP-Seq_ESCs_Mouse1.08815658
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08569490
86NFYB_21822215_ChIP-Seq_K562_Human1.07727957
87CEBPB_22108803_ChIP-Seq_LS180_Human1.07531655
88SA1_27219007_Chip-Seq_Bcells_Human1.07268972
89RXR_22108803_ChIP-Seq_LS180_Human1.07046107
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.06629044
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06508711
92SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05909995
93* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05819662
94TAF2_19829295_ChIP-Seq_ESCs_Human1.04806199
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03959322
96GATA3_24758297_ChIP-Seq_MCF-7_Human1.00903147
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00716604
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00219408
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00094473
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99620445
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96848229
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96448803
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.95805894
104CDX2_22108803_ChIP-Seq_LS180_Human0.95798023
105AR_21909140_ChIP-Seq_LNCAP_Human0.95332477
106HNF4A_19822575_ChIP-Seq_HepG2_Human0.94413357
107P300_27268052_Chip-Seq_Bcells_Human0.94077814
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93132630
109ERA_21632823_ChIP-Seq_H3396_Human0.92341520
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92085409
111P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91170201
112TP63_23658742_ChIP-Seq_EP156T_Human0.90185897
113BP1_19119308_ChIP-ChIP_Hs578T_Human0.90034700
114CBP_21632823_ChIP-Seq_H3396_Human0.89343086
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88858340
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.88087700
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87150916
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85787769
119AR_20517297_ChIP-Seq_VCAP_Human0.85348331
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85147691
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84446858
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83412458
123SOX2_21211035_ChIP-Seq_LN229_Human0.82006291
124TBL1_22424771_ChIP-Seq_293T_Human0.81984478
125BCOR_27268052_Chip-Seq_Bcells_Human0.80876690
126CJUN_26792858_Chip-Seq_BT549_Human0.79562655
127GATA3_21867929_ChIP-Seq_CD8_Mouse0.78851447
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78006843
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77570889
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.77276047
131ATF3_27146783_Chip-Seq_COLON_Human0.76860847
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.76380387
133ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75943447
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75096639
135GATA2_19941826_ChIP-Seq_K562_Human0.74803384
136FLI1_21867929_ChIP-Seq_CD8_Mouse0.74431625
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74032235
138ETS1_21867929_ChIP-Seq_TH2_Mouse0.73978885
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73688351
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73416826
141LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.73318697
142ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72495530
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72134091
144DROSHA_22980978_ChIP-Seq_HELA_Human0.72088281
145FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.71582656
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71552633
147* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.70492530
148GATA1_26923725_Chip-Seq_HPCs_Mouse0.70000929
149UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.69464092
150EGR1_19374776_ChIP-ChIP_THP-1_Human0.65928087
151NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.64406673
152CTNNB1_20460455_ChIP-Seq_HCT116_Human0.64077056
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63611310
154ELF5_23300383_ChIP-Seq_T47D_Human0.62815861
155SMC4_20622854_ChIP-Seq_HELA_Human0.62409190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003868_abnormal_feces_composition8.32124608
2MP0008875_abnormal_xenobiotic_pharmacok6.37614995
3MP0010030_abnormal_orbit_morphology3.95093809
4MP0010234_abnormal_vibrissa_follicle3.92696410
5MP0002139_abnormal_hepatobiliary_system3.76111725
6MP0001346_abnormal_lacrimal_gland3.63643366
7MP0004264_abnormal_extraembryonic_tissu3.56840362
8MP0002254_reproductive_system_inflammat3.32668732
9MP0002877_abnormal_melanocyte_morpholog2.99536015
10MP0005248_abnormal_Harderian_gland2.97931804
11MP0004019_abnormal_vitamin_homeostasis2.83599256
12MP0003959_abnormal_lean_body2.79410854
13MP0000537_abnormal_urethra_morphology2.72503851
14MP0005220_abnormal_exocrine_pancreas2.63353150
15MP0005083_abnormal_biliary_tract2.61646743
16MP0002132_abnormal_respiratory_system2.35939136
17MP0005360_urolithiasis2.31887970
18MP0003806_abnormal_nucleotide_metabolis2.30653310
19MP0003186_abnormal_redox_activity2.25287518
20MP0001666_abnormal_nutrient_absorption2.23836881
21MP0005085_abnormal_gallbladder_physiolo2.19338090
22MP0002909_abnormal_adrenal_gland2.18792804
23MP0000566_synostosis2.09747947
24MP0005365_abnormal_bile_salt2.09592475
25MP0010352_gastrointestinal_tract_polyps2.09291031
26MP0008789_abnormal_olfactory_epithelium2.08143477
27MP0004043_abnormal_pH_regulation2.05526251
28MP0003566_abnormal_cell_adhesion1.95303303
29MP0003183_abnormal_peptide_metabolism1.92413725
30MP0000678_abnormal_parathyroid_gland1.88938543
31MP0010678_abnormal_skin_adnexa1.88233046
32MP0010368_abnormal_lymphatic_system1.79993804
33MP0000762_abnormal_tongue_morphology1.78915743
34MP0002277_abnormal_respiratory_mucosa1.75355933
35MP0000467_abnormal_esophagus_morphology1.71956438
36MP0005408_hypopigmentation1.71059109
37MP0010386_abnormal_urinary_bladder1.71023637
38MP0005448_abnormal_energy_balance1.70181737
39MP0009840_abnormal_foam_cell1.66237283
40MP0002098_abnormal_vibrissa_morphology1.64865341
41MP0006054_spinal_hemorrhage1.62097181
42MP0000383_abnormal_hair_follicle1.54751947
43MP0001958_emphysema1.52967121
44MP0000613_abnormal_salivary_gland1.50108034
45MP0002693_abnormal_pancreas_physiology1.49538452
46MP0010155_abnormal_intestine_physiology1.46976967
47MP0003828_pulmonary_edema1.42085454
48MP0010329_abnormal_lipoprotein_level1.37118938
49MP0002796_impaired_skin_barrier1.34530510
50MP0003300_gastrointestinal_ulcer1.31537962
51MP0003453_abnormal_keratinocyte_physiol1.22270627
52MP0005164_abnormal_response_to1.20588584
53MP0000579_abnormal_nail_morphology1.16700809
54MP0003724_increased_susceptibility_to1.16270748
55MP0009379_abnormal_foot_pigmentation1.15716594
56MP0004883_abnormal_blood_vessel1.15241959
57MP0001849_ear_inflammation1.15069201
58MP0001873_stomach_inflammation1.12156143
59MP0000465_gastrointestinal_hemorrhage1.08639139
60MP0009764_decreased_sensitivity_to1.07775591
61MP0005332_abnormal_amino_acid1.05065325
62MP0005452_abnormal_adipose_tissue1.04048395
63MP0002234_abnormal_pharynx_morphology1.04016495
64MP0009053_abnormal_anal_canal1.03947677
65MP0005499_abnormal_olfactory_system1.03323437
66MP0005394_taste/olfaction_phenotype1.03323437
67MP0009643_abnormal_urine_homeostasis0.99609090
68MP0003866_abnormal_defecation0.99539349
69MP0005084_abnormal_gallbladder_morpholo0.97225527
70MP0001663_abnormal_digestive_system0.96988160
71MP0002060_abnormal_skin_morphology0.96074491
72MP0005388_respiratory_system_phenotype0.94573127
73MP0002133_abnormal_respiratory_system0.94573127
74MP0002078_abnormal_glucose_homeostasis0.93304383
75MP0004782_abnormal_surfactant_physiolog0.91793538
76MP0003953_abnormal_hormone_level0.89939732
77MP0005165_increased_susceptibility_to0.89877209
78MP0005334_abnormal_fat_pad0.88760908
79MP0000490_abnormal_crypts_of0.87220765
80MP0003879_abnormal_hair_cell0.86173437
81MP0003329_amyloid_beta_deposits0.85187619
82MP0001845_abnormal_inflammatory_respons0.84027410
83MP0001756_abnormal_urination0.83941691
84MP0001216_abnormal_epidermal_layer0.83289537
85MP0001501_abnormal_sleep_pattern0.83048404
86MP0001915_intracranial_hemorrhage0.82864723
87MP0003252_abnormal_bile_duct0.82090625
88MP0000462_abnormal_digestive_system0.81417381
89MP0000470_abnormal_stomach_morphology0.80625178
90MP0005381_digestive/alimentary_phenotyp0.80252180
91MP0004147_increased_porphyrin_level0.79668151
92MP0000681_abnormal_thyroid_gland0.77825130
93MP0001664_abnormal_digestion0.77223132
94MP0003690_abnormal_glial_cell0.76169122
95MP0002876_abnormal_thyroid_physiology0.74903941
96MP0005166_decreased_susceptibility_to0.73879043
97MP0005319_abnormal_enzyme/_coenzyme0.73428461
98MP0003705_abnormal_hypodermis_morpholog0.73186318
99MP0000477_abnormal_intestine_morphology0.72698985
100MP0001765_abnormal_ion_homeostasis0.71420298
101MP0002233_abnormal_nose_morphology0.70473682
102MP0000598_abnormal_liver_morphology0.69114021
103MP0003045_fibrosis0.69031158
104MP0003011_delayed_dark_adaptation0.67870754
105MP0002295_abnormal_pulmonary_circulatio0.67766693
106MP0005023_abnormal_wound_healing0.67520225
107MP0000377_abnormal_hair_follicle0.66854346
108MP0009785_altered_susceptibility_to0.66132374
109MP0002118_abnormal_lipid_homeostasis0.66044363
110MP0005636_abnormal_mineral_homeostasis0.65123776
111MP0002136_abnormal_kidney_physiology0.65047790
112MP0002138_abnormal_hepatobiliary_system0.64781795
113MP0000627_abnormal_mammary_gland0.64461934
114MP0003075_altered_response_to0.64136887
115MP0000538_abnormal_urinary_bladder0.62865713
116MP0003195_calcinosis0.61280778
117MP0000609_abnormal_liver_physiology0.60941731
118MP0008004_abnormal_stomach_pH0.60839457
119MP0009780_abnormal_chondrocyte_physiolo0.59197501
120MP0002970_abnormal_white_adipose0.58269927
121MP0004858_abnormal_nervous_system0.57104066
122MP0003436_decreased_susceptibility_to0.55863579
123MP0005376_homeostasis/metabolism_phenot0.55347353
124MP0010771_integument_phenotype0.55007540
125MP0000049_abnormal_middle_ear0.53821375
126MP0004947_skin_inflammation0.53659371
127MP0009642_abnormal_blood_homeostasis0.53465816
128MP0005409_darkened_coat_color0.52861310
129MP0004185_abnormal_adipocyte_glucose0.52592650
130MP0001502_abnormal_circadian_rhythm0.49212477
131MP0008469_abnormal_protein_level0.48091553
132MP0001944_abnormal_pancreas_morphology0.46555148
133MP0002089_abnormal_postnatal_growth/wei0.43568607
134MP0008872_abnormal_physiological_respon0.42302637
135MP0001485_abnormal_pinna_reflex0.39252808
136MP0003283_abnormal_digestive_organ0.38922524
137MP0001764_abnormal_homeostasis0.38859392
138MP0003718_maternal_effect0.38217895
139MP0005058_abnormal_lysosome_morphology0.36640456
140MP0003943_abnormal_hepatobiliary_system0.35124425
141MP0001731_abnormal_postnatal_growth0.34173570
142MP0004484_altered_response_of0.34014838
143MP0005410_abnormal_fertilization0.32690750
144MP0000367_abnormal_coat/_hair0.32328102
145MP0002822_catalepsy0.31869039
146MP0005451_abnormal_body_composition0.30997472
147MP0002166_altered_tumor_susceptibility0.30285131
148MP0000858_altered_metastatic_potential0.29310052
149MP0001790_abnormal_immune_system0.28173527
150MP0005387_immune_system_phenotype0.28173527

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)8.06768327
2Pancreatitis (HP:0001733)6.42752836
3Right ventricular cardiomyopathy (HP:0011663)5.81953243
4Renal salt wasting (HP:0000127)5.37358168
5Humeroradial synostosis (HP:0003041)5.20664977
6Synostosis involving the elbow (HP:0003938)5.20664977
7Hydroxyprolinuria (HP:0003080)5.00770851
8Abnormality of proline metabolism (HP:0010907)5.00770851
9Onycholysis (HP:0001806)4.69293332
10Increased circulating renin level (HP:0000848)4.50542386
11Malnutrition (HP:0004395)4.36288842
12Abnormality of chloride homeostasis (HP:0011422)4.26087005
13Hyperaldosteronism (HP:0000859)4.19410291
14Bronchomalacia (HP:0002780)4.15473983
15Abnormality of the pleura (HP:0002103)4.11802857
16Gout (HP:0001997)3.88235958
17Abnormality of renin-angiotensin system (HP:0000847)3.72445351
18Ulnar bowing (HP:0003031)3.58391615
19Hypokalemic alkalosis (HP:0001949)3.57541827
20Stenosis of the external auditory canal (HP:0000402)3.54355913
21Labial hypoplasia (HP:0000066)3.37739486
22Chronic bronchitis (HP:0004469)3.33682184
23Stomach cancer (HP:0012126)3.31783342
24Large eyes (HP:0001090)3.27384687
25Milia (HP:0001056)3.22571032
26Abnormality of fatty-acid metabolism (HP:0004359)3.20582737
27Distal lower limb muscle weakness (HP:0009053)3.19902993
28Tetraparesis (HP:0002273)3.14177507
29Metabolic alkalosis (HP:0200114)3.10989090
30Hypoplastic female external genitalia (HP:0012815)3.08598118
31Tetany (HP:0001281)3.06160950
32Choroideremia (HP:0001139)3.06140587
33Micronodular cirrhosis (HP:0001413)3.05989855
34Impaired platelet aggregation (HP:0003540)3.05915127
35Abnormal platelet function (HP:0011869)3.05915127
36Abnormal pancreas size (HP:0012094)3.00312586
37Alopecia of scalp (HP:0002293)2.94748587
38Lip pit (HP:0100267)2.91956179
39Abnormality of the vitamin B12 metabolism (HP:0004341)2.91714216
40Syncope (HP:0001279)2.90945368
41Abnormality of the distal phalanges of the toes (HP:0010182)2.89182357
42Esophageal varix (HP:0002040)2.89161380
43Abnormality of urine glucose concentration (HP:0011016)2.88599890
44Glycosuria (HP:0003076)2.88599890
45Ileus (HP:0002595)2.88512188
46Polycythemia (HP:0001901)2.88495077
47Fragile skin (HP:0001030)2.87191359
48Hypotension (HP:0002615)2.85007747
49Fragile nails (HP:0001808)2.80421889
50Abnormality of renal excretion (HP:0011036)2.79113885
51Systemic lupus erythematosus (HP:0002725)2.78909466
52Abnormality of vitamin B metabolism (HP:0004340)2.76478646
53Tubulointerstitial nephritis (HP:0001970)2.72379698
54Tubulointerstitial fibrosis (HP:0005576)2.70092772
55Abnormality of the labia (HP:0000058)2.69048852
56Woolly hair (HP:0002224)2.68616911
57Abnormal blistering of the skin (HP:0008066)2.67910626
58Esophageal atresia (HP:0002032)2.65339564
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63932417
60Palpitations (HP:0001962)2.52482944
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51474963
62Pustule (HP:0200039)2.48885117
63Split foot (HP:0001839)2.45544553
64Congenital sensorineural hearing impairment (HP:0008527)2.42303912
65Atrophic scars (HP:0001075)2.41026921
66Aplasia involving bones of the extremities (HP:0009825)2.40622115
67Aplasia involving bones of the upper limbs (HP:0009823)2.40622115
68Aplasia of the phalanges of the hand (HP:0009802)2.40622115
69Proximal tubulopathy (HP:0000114)2.39279566
70Bifid scrotum (HP:0000048)2.37132752
71Abnormality of vitamin metabolism (HP:0100508)2.36881308
72Bowing of the arm (HP:0006488)2.36139032
73Bowed forearm bones (HP:0003956)2.36139032
74Glomerulonephritis (HP:0000099)2.36002766
75Hypoplasia of dental enamel (HP:0006297)2.34545803
76Adrenal overactivity (HP:0002717)2.33591552
77Vaginal fistula (HP:0004320)2.33161121
78Hypomagnesemia (HP:0002917)2.31787350
79Abnormal hemoglobin (HP:0011902)2.30724894
80Short nail (HP:0001799)2.30311334
81Interstitial pulmonary disease (HP:0006530)2.30008208
82Abnormal drinking behavior (HP:0030082)2.28572497
83Polydipsia (HP:0001959)2.28572497
84Tubular atrophy (HP:0000092)2.25499210
85Choanal stenosis (HP:0000452)2.23628484
86Dehydration (HP:0001944)2.21194686
87Reduced antithrombin III activity (HP:0001976)2.21130037
88Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20362819
89Plantar hyperkeratosis (HP:0007556)2.20096704
90Anal atresia (HP:0002023)2.16879316
91Abnormality of magnesium homeostasis (HP:0004921)2.15209335
92Hypercalciuria (HP:0002150)2.13852722
93Abnormality of sulfur amino acid metabolism (HP:0004339)2.13422832
94Abnormal sex determination (HP:0012244)2.12452736
95Sex reversal (HP:0012245)2.12452736
96Vascular calcification (HP:0004934)2.10533942
97Pili torti (HP:0003777)2.07212320
98Glomerulosclerosis (HP:0000096)2.06426478
99Hyperammonemia (HP:0001987)2.05978355
100Ventricular arrhythmia (HP:0004308)2.04066955
101Increased purine levels (HP:0004368)2.03203857
102Hyperuricemia (HP:0002149)2.03203857
103Popliteal pterygium (HP:0009756)2.02483593
104Chronic diarrhea (HP:0002028)2.01838386
105Steatorrhea (HP:0002570)17.8186860
106Fat malabsorption (HP:0002630)14.4760815
107Exocrine pancreatic insufficiency (HP:0001738)10.6881352
108Hypoproteinemia (HP:0003075)10.1266357
109Osteomalacia (HP:0002749)1.99509825
110Potter facies (HP:0002009)1.99296547
111Facial shape deformation (HP:0011334)1.99296547
112Abdominal pain (HP:0002027)1.98397528
113Nasal polyposis (HP:0100582)1.97632973
114Hyperphosphatemia (HP:0002905)1.97405759
115Ventricular fibrillation (HP:0001663)1.96836723
116Complement deficiency (HP:0004431)1.95873936
117Chronic otitis media (HP:0000389)1.95745579
118Pigmentary retinal degeneration (HP:0001146)1.95610691
119Nausea (HP:0002018)1.95401609
120Abnormality of small intestinal villus morphology (HP:0011472)1.93985444
121Villous atrophy (HP:0011473)1.93985444
122Curly hair (HP:0002212)1.93468178
123Scanning speech (HP:0002168)1.93376436
124Pterygium (HP:0001059)1.89709237
125Mildly elevated creatine phosphokinase (HP:0008180)1.89067429
126Orchitis (HP:0100796)1.88901030
127Abnormal biliary tract morphology (HP:0012440)1.88833240
128Chondrocalcinosis (HP:0000934)1.88235651
129Paraparesis (HP:0002385)1.87445985
130Type I transferrin isoform profile (HP:0003642)1.87019163
131Cardiovascular calcification (HP:0011915)1.86709163
132Subacute progressive viral hepatitis (HP:0006572)1.85745490
133Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.85608615
134Decreased circulating renin level (HP:0003351)1.84741465
135Alkalosis (HP:0001948)1.83996771
136Femoral bowing (HP:0002980)1.82166285
137Bronchiectasis (HP:0002110)1.81021879
138Abnormality of purine metabolism (HP:0004352)1.79896622
139Rectal prolapse (HP:0002035)1.79649895
140Hypobetalipoproteinemia (HP:0003563)1.79234372
141Hypoplastic labia majora (HP:0000059)1.78598535
142Abnormality of complement system (HP:0005339)1.76668725
143Nephritis (HP:0000123)1.76181609
144Xanthomatosis (HP:0000991)1.74161794
145Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70217110
146Dicarboxylic aciduria (HP:0003215)1.70217110
147Metabolic acidosis (HP:0001942)1.67069791
148Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.65951766
149Abdominal distention (HP:0003270)1.57848025
150Renal tubular acidosis (HP:0001947)1.57311016
151Abnormal protein glycosylation (HP:0012346)1.57073873
152Abnormal glycosylation (HP:0012345)1.57073873
153Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.57073873
154Abnormal protein N-linked glycosylation (HP:0012347)1.57073873
155Megaloblastic anemia (HP:0001889)1.56930967
156Insulin-resistant diabetes mellitus (HP:0000831)1.56890102
157Lower limb hyperreflexia (HP:0002395)1.54964412
158Hyperphosphaturia (HP:0003109)1.53048386
159Widely patent fontanelles and sutures (HP:0004492)1.52212194
160Hypophosphatemia (HP:0002148)1.46715145
161Male infertility (HP:0003251)1.46419055
162Late onset (HP:0003584)1.43413046
163Abnormality of nucleobase metabolism (HP:0010932)1.42587620
164Abnormality of the intrinsic pathway (HP:0010989)1.42230352
165Increased CSF protein (HP:0002922)1.39559083
166Abnormality of the nasal septum (HP:0000419)1.38915023
167Abnormality of alkaline phosphatase activity (HP:0004379)1.38080334
168Nephrolithiasis (HP:0000787)1.37978174
169Large for gestational age (HP:0001520)1.36965904
170Abnormality of methionine metabolism (HP:0010901)1.35109854
171Abnormal tarsal ossification (HP:0008369)1.34899634
172Hypoalbuminemia (HP:0003073)1.34279793
173Abnormal albumin level (HP:0012116)1.34279793
174Abnormal enzyme/coenzyme activity (HP:0012379)1.34153537
175Axonal loss (HP:0003447)1.33411300
176Abnormal urine phosphate concentration (HP:0012599)1.33262624
177Abnormality of serine family amino acid metabolism (HP:0010894)1.33023361
178Abnormality of glycine metabolism (HP:0010895)1.33023361
179Ketosis (HP:0001946)1.32481564
180Goiter (HP:0000853)1.32129258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.10984203
2EIF2AK33.86109456
3ERBB33.68721378
4MST1R3.60872837
5EPHA23.46304960
6EPHA33.25580717
7MAP3K23.25380130
8ACVR1B3.15518591
9EPHB22.97580940
10FRK2.96116308
11NME12.93555537
12RPS6KB22.79719513
13DAPK22.74588598
14TRPM72.62886575
15EPHB12.62355188
16MAP3K32.37650345
17FER2.32763312
18TAOK32.27379728
19GRK12.15502513
20MAP2K22.10921783
21LMTK21.83905238
22ERN11.76175701
23MAPKAPK31.69456017
24STK101.57869841
25ERBB21.48177935
26SGK21.42956545
27TBK11.42102126
28MYLK1.41694845
29SGK31.38694138
30PDK21.37415893
31OXSR11.31091023
32FGFR41.30945179
33LATS11.24477146
34INSRR1.22197564
35MAP2K11.21829048
36SGK2231.21749452
37SGK4941.21749452
38NEK61.21120309
39RIPK11.21023458
40LRRK21.20727514
41CDK61.17810655
42STK391.13205624
43MAPK151.13033387
44STK241.12938718
45HIPK21.09442863
46FGFR21.07845977
47NLK1.07659559
48PRKD31.06033617
49PTK61.05272375
50PBK1.03894569
51PTK21.00712838
52BMPR1B1.00037314
53TAOK10.98947201
54TEC0.97287476
55PIM20.95879205
56ZAP700.92207052
57EIF2AK10.90916483
58STK160.90635087
59BCR0.83883309
60WNK40.83433668
61PDGFRB0.83387631
62PINK10.82934209
63ALK0.82750003
64PRKG20.82587272
65MAP3K10.79853169
66TESK10.78323499
67IRAK20.78080476
68GRK60.77678502
69MET0.76079104
70KSR10.75653270
71NTRK30.75455503
72PIK3CA0.75153318
73MAP3K120.72330684
74CDK190.64699584
75FGFR30.61802358
76STK30.60888441
77PRKCI0.60096576
78PDK10.59505213
79IRAK10.58490670
80TGFBR10.58108930
81MATK0.56076046
82STK38L0.56050915
83MAP3K50.54539724
84NEK90.53300806
85MELK0.53058636
86TYRO30.52401033
87ITK0.51644068
88MAP2K60.51587230
89PAK40.50093975
90PRKCD0.49264519
91MAPK70.48596559
92MAP3K110.48152313
93PRKD10.44600762
94PDPK10.44371450
95SRC0.43415109
96IKBKE0.42924712
97TAOK20.41967420
98PRKCE0.41825300
99DDR20.41633169
100TIE10.38891741
101STK380.38178441
102SIK10.36735945
103PRKAA20.35652981
104BMX0.34980675
105DAPK10.34875906
106IGF1R0.34808798
107STK40.34563127
108PRKCQ0.34108907
109TYK20.33937713
110MAP3K90.33339267
111PRKACG0.32963611
112KSR20.32236257
113MAP3K70.32099640
114ROCK10.31872134
115CAMK2D0.31750098
116PAK30.31556774
117RPS6KA50.31346964
118JAK20.30149780
119PASK0.30076993
120TGFBR20.29622320
121DAPK30.28296594
122SCYL20.26965952
123FYN0.26880894
124PRKCA0.25745655
125JAK10.25378066
126MAPK120.25229148
127CDC42BPA0.24645192
128TNIK0.24212691
129ERBB40.23551546
130HCK0.23077609
131ROCK20.23004799
132MAP3K100.22694566
133WNK10.22577169
134FGFR10.21910437
135CAMK2B0.21396430
136MAP3K140.21391901
137CDK80.20968634
138MAPKAPK50.20736537
139MAPKAPK20.19793260
140BCKDK0.19186443
141CSNK1A10.18561292

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009826.01679168
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.76187933
3Chemical carcinogenesis_Homo sapiens_hsa052045.00966266
4Sulfur metabolism_Homo sapiens_hsa009204.21285963
5Glutathione metabolism_Homo sapiens_hsa004803.55970250
6Tyrosine metabolism_Homo sapiens_hsa003502.94019094
7Histidine metabolism_Homo sapiens_hsa003402.58477631
8Retinol metabolism_Homo sapiens_hsa008302.55129116
9Caffeine metabolism_Homo sapiens_hsa002322.46629267
10Sulfur relay system_Homo sapiens_hsa041222.42874938
11Phenylalanine metabolism_Homo sapiens_hsa003602.35283962
12Fatty acid degradation_Homo sapiens_hsa000712.16464701
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.13902333
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81811305
15beta-Alanine metabolism_Homo sapiens_hsa004101.72485989
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.70207477
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51147201
18Fat digestion and absorption_Homo sapiens_hsa049751.50707576
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35203267
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35059028
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33988983
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32420136
23Gastric acid secretion_Homo sapiens_hsa049711.17901002
24Arachidonic acid metabolism_Homo sapiens_hsa005901.13303624
25Mineral absorption_Homo sapiens_hsa049781.07360775
26Bile secretion_Homo sapiens_hsa049761.05832000
27Steroid biosynthesis_Homo sapiens_hsa001001.03205320
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00294948
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00106813
30Other glycan degradation_Homo sapiens_hsa005111.00103899
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87624367
32Galactose metabolism_Homo sapiens_hsa000520.86726178
33Tight junction_Homo sapiens_hsa045300.85402813
34Bladder cancer_Homo sapiens_hsa052190.75683312
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71798917
36Steroid hormone biosynthesis_Homo sapiens_hsa001400.71570768
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71461597
38Adherens junction_Homo sapiens_hsa045200.67518822
39Salivary secretion_Homo sapiens_hsa049700.66911425
40Leishmaniasis_Homo sapiens_hsa051400.66485179
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.66316610
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.66057448
43Pentose phosphate pathway_Homo sapiens_hsa000300.65987887
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65966369
45Starch and sucrose metabolism_Homo sapiens_hsa005000.62949633
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61498294
47PPAR signaling pathway_Homo sapiens_hsa033200.60117996
48Vitamin digestion and absorption_Homo sapiens_hsa049770.57132575
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54424670
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52783816
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50240902
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.50183673
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50084454
54Vitamin B6 metabolism_Homo sapiens_hsa007500.49863047
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.48830289
56Thyroid hormone synthesis_Homo sapiens_hsa049180.47919903
57Renin-angiotensin system_Homo sapiens_hsa046140.47424490
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47091434
59Vibrio cholerae infection_Homo sapiens_hsa051100.43015273
60Complement and coagulation cascades_Homo sapiens_hsa046100.41514269
61Toxoplasmosis_Homo sapiens_hsa051450.41361141
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.40216772
63Glycerolipid metabolism_Homo sapiens_hsa005610.39378070
64Hepatitis C_Homo sapiens_hsa051600.38389276
65Tryptophan metabolism_Homo sapiens_hsa003800.37738810
66Thyroid cancer_Homo sapiens_hsa052160.37348982
67Pancreatic secretion_Homo sapiens_hsa049720.36730559
68ECM-receptor interaction_Homo sapiens_hsa045120.36590633
69Pertussis_Homo sapiens_hsa051330.36031406
70Linoleic acid metabolism_Homo sapiens_hsa005910.35856380
71Arginine biosynthesis_Homo sapiens_hsa002200.34626914
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34324334
73Notch signaling pathway_Homo sapiens_hsa043300.33713603
74Protein digestion and absorption_Homo sapiens_hsa049740.33540956
75Fructose and mannose metabolism_Homo sapiens_hsa000510.32958307
76Circadian rhythm_Homo sapiens_hsa047100.31130258
77Asthma_Homo sapiens_hsa053100.29921297
78Peroxisome_Homo sapiens_hsa041460.29433741
79Salmonella infection_Homo sapiens_hsa051320.29236793
80Propanoate metabolism_Homo sapiens_hsa006400.28697776
81Selenocompound metabolism_Homo sapiens_hsa004500.28695038
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26920606
83Ether lipid metabolism_Homo sapiens_hsa005650.26128033
84Carbon metabolism_Homo sapiens_hsa012000.25822337
85Sphingolipid metabolism_Homo sapiens_hsa006000.23951785
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.23415859
87Hippo signaling pathway_Homo sapiens_hsa043900.23156791
88Proteoglycans in cancer_Homo sapiens_hsa052050.22520042
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.22448420
90Amoebiasis_Homo sapiens_hsa051460.21959863
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21095861
92TNF signaling pathway_Homo sapiens_hsa046680.20905417
93Pyruvate metabolism_Homo sapiens_hsa006200.20333449
94Fatty acid metabolism_Homo sapiens_hsa012120.20054435
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19710564
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.19571470
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19489634
98Viral myocarditis_Homo sapiens_hsa054160.18853989
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18794738
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18597156
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17602107
102ABC transporters_Homo sapiens_hsa020100.17182351
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16918755
104Staphylococcus aureus infection_Homo sapiens_hsa051500.14835369
105TGF-beta signaling pathway_Homo sapiens_hsa043500.13020163
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11967110
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11859795
108N-Glycan biosynthesis_Homo sapiens_hsa005100.11134415
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09678353
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09343041
111Type I diabetes mellitus_Homo sapiens_hsa049400.08947343
112Folate biosynthesis_Homo sapiens_hsa007900.08562356
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08383691
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.08232726
115Influenza A_Homo sapiens_hsa051640.08216880
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07197218
117Arginine and proline metabolism_Homo sapiens_hsa003300.07067046
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.06721198
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05837316
120Butanoate metabolism_Homo sapiens_hsa006500.05669966
121Metabolic pathways_Homo sapiens_hsa011000.05178899
122Protein export_Homo sapiens_hsa030600.03885980
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.03088305
124Allograft rejection_Homo sapiens_hsa053300.01089740
125Autoimmune thyroid disease_Homo sapiens_hsa053200.00626698
126Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0897282
127Regulation of autophagy_Homo sapiens_hsa04140-0.0762285
128Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0405575
129Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0297740
130Biosynthesis of amino acids_Homo sapiens_hsa01230-0.0203395
131Graft-versus-host disease_Homo sapiens_hsa05332-0.0054682
132Insulin secretion_Homo sapiens_hsa04911-0.0042795

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