REC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.42159546
2cilium movement (GO:0003341)5.44308932
3viral transcription (GO:0019083)5.37528308
4epithelial cilium movement (GO:0003351)5.28556094
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.27248576
6translational termination (GO:0006415)5.23719268
7maturation of SSU-rRNA (GO:0030490)5.02541232
8translational elongation (GO:0006414)4.75256564
9DNA replication checkpoint (GO:0000076)4.72235101
10pyrimidine nucleobase catabolic process (GO:0006208)4.71977051
11ribosomal small subunit biogenesis (GO:0042274)4.67610182
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.67103599
13definitive hemopoiesis (GO:0060216)4.60514599
14protein targeting to ER (GO:0045047)4.55404518
15cotranslational protein targeting to membrane (GO:0006613)4.54472721
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.39015107
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.37275238
18oocyte development (GO:0048599)4.35043303
19erythrocyte maturation (GO:0043249)4.33069000
20protein localization to endoplasmic reticulum (GO:0070972)4.31617769
21axoneme assembly (GO:0035082)4.25935882
22intraciliary transport (GO:0042073)4.17411276
23cellular protein complex disassembly (GO:0043624)4.12662926
24fusion of sperm to egg plasma membrane (GO:0007342)4.09814005
25translational initiation (GO:0006413)4.08233094
26synapsis (GO:0007129)4.00553381
27protein complex disassembly (GO:0043241)3.99532771
28viral life cycle (GO:0019058)3.99333412
29fat-soluble vitamin catabolic process (GO:0042363)3.93710283
30vitamin catabolic process (GO:0009111)3.93710283
31regulation of histone H3-K9 methylation (GO:0051570)3.88132353
32establishment of mitochondrion localization (GO:0051654)3.79993569
33macromolecular complex disassembly (GO:0032984)3.70840050
34regulation of cilium movement (GO:0003352)3.69917187
35histone H4-K12 acetylation (GO:0043983)3.67024330
36mitochondrion transport along microtubule (GO:0047497)3.66912835
37establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.66912835
38left/right pattern formation (GO:0060972)3.64512496
39behavioral response to nicotine (GO:0035095)3.61287876
40hematopoietic stem cell differentiation (GO:0060218)3.55154087
41nucleobase catabolic process (GO:0046113)3.50299899
42DNA deamination (GO:0045006)3.48030155
43pyrimidine nucleotide catabolic process (GO:0006244)3.47620706
44cell migration in hindbrain (GO:0021535)3.47450141
45binding of sperm to zona pellucida (GO:0007339)3.47018847
46sperm-egg recognition (GO:0035036)3.45257435
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43585792
48piRNA metabolic process (GO:0034587)3.35606570
49chromosome organization involved in meiosis (GO:0070192)3.33997522
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.31575842
51formation of translation preinitiation complex (GO:0001731)3.31429913
52ventricular system development (GO:0021591)3.30626984
53mucosal-associated lymphoid tissue development (GO:0048537)3.27546902
54Peyers patch development (GO:0048541)3.27546902
55negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.27060408
56* reciprocal meiotic recombination (GO:0007131)3.23985949
57* reciprocal DNA recombination (GO:0035825)3.23985949
58* sister chromatid cohesion (GO:0007062)3.19650452
59synaptonemal complex assembly (GO:0007130)3.18674613
60histone H2A acetylation (GO:0043968)3.18542751
61mRNA catabolic process (GO:0006402)3.15637044
62sperm motility (GO:0030317)3.13832710
63poly(A)+ mRNA export from nucleus (GO:0016973)3.13356928
64negative regulation of erythrocyte differentiation (GO:0045647)3.13211399
65protein localization to cilium (GO:0061512)3.12820735
66histone H3-K9 methylation (GO:0051567)3.12033287
67DNA strand elongation involved in DNA replication (GO:0006271)3.09798628
68DNA strand elongation (GO:0022616)3.08497015
69axonemal dynein complex assembly (GO:0070286)3.06822997
70purine deoxyribonucleotide catabolic process (GO:0009155)3.06133849
71RNA catabolic process (GO:0006401)3.05430740
72protein targeting to membrane (GO:0006612)3.05114421
73regulation of gene silencing by miRNA (GO:0060964)3.03325105
74regulation of gene silencing by RNA (GO:0060966)3.03325105
75regulation of posttranscriptional gene silencing (GO:0060147)3.03325105
76telomere maintenance via semi-conservative replication (GO:0032201)3.03317214
77establishment of apical/basal cell polarity (GO:0035089)3.02368706
78ribosomal large subunit biogenesis (GO:0042273)3.01750942
79plasma membrane fusion (GO:0045026)3.00965998
80synaptonemal complex organization (GO:0070193)3.00584432
81cell-cell recognition (GO:0009988)2.97117460
82aggressive behavior (GO:0002118)2.95805551
83chromosome condensation (GO:0030261)2.95407430
84negative regulation of histone methylation (GO:0031061)2.94570660
85* spermatid development (GO:0007286)2.94532076
86regulation of translational fidelity (GO:0006450)2.92942057
87motile cilium assembly (GO:0044458)2.92460635
88cilium organization (GO:0044782)2.91684557
89phosphatidylglycerol biosynthetic process (GO:0006655)2.91433945
90ribonucleoprotein complex biogenesis (GO:0022613)2.91385359
91antigen processing and presentation via MHC class Ib (GO:0002475)2.90616219
92cilium assembly (GO:0042384)2.90147334
93nucleobase biosynthetic process (GO:0046112)2.89200568
94deoxyribonucleotide catabolic process (GO:0009264)2.88210404
95histone H3 deacetylation (GO:0070932)2.87985965
96spinal cord association neuron differentiation (GO:0021527)2.86633156
97microtubule bundle formation (GO:0001578)2.86494918
98positive regulation of T cell apoptotic process (GO:0070234)2.86340481
99regulation of microtubule-based movement (GO:0060632)2.85935919
100nonmotile primary cilium assembly (GO:0035058)2.85918120
101DNA replication initiation (GO:0006270)2.85746703
102receptor recycling (GO:0001881)2.85508675
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84404546
104DNA packaging (GO:0006323)2.83866432
105protein-DNA complex disassembly (GO:0032986)2.83018041
106nucleosome disassembly (GO:0006337)2.83018041
107histone H3-K9 modification (GO:0061647)2.83011586
108protein polyglutamylation (GO:0018095)2.81489605
109nucleotide-excision repair, DNA damage removal (GO:0000718)2.81426628
110DNA excision (GO:0044349)2.81426628
111post-embryonic morphogenesis (GO:0009886)2.79195455
112fucose catabolic process (GO:0019317)2.78329571
113L-fucose metabolic process (GO:0042354)2.78329571
114L-fucose catabolic process (GO:0042355)2.78329571
115acrosome assembly (GO:0001675)2.77569224
116translation (GO:0006412)2.75441125
117cellular response to interferon-beta (GO:0035458)2.75323417
118pre-miRNA processing (GO:0031054)2.74494983
119cell differentiation involved in metanephros development (GO:0072202)2.73688878
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.73017497
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73017497
122male meiosis (GO:0007140)2.72807375
123* meiotic nuclear division (GO:0007126)2.72534646
124cilium or flagellum-dependent cell motility (GO:0001539)2.72279530
125* seminiferous tubule development (GO:0072520)2.68579910
126negative regulation of meiotic cell cycle (GO:0051447)2.67543680
127tongue development (GO:0043586)2.67205389
128chaperone-mediated protein complex assembly (GO:0051131)2.65291335
129mitotic nuclear envelope disassembly (GO:0007077)2.65033342
130nuclear pore organization (GO:0006999)2.63857399
131nuclear pore complex assembly (GO:0051292)2.63226635
132regulation of nuclear cell cycle DNA replication (GO:0033262)2.63172697
133positive regulation of gastrulation (GO:2000543)2.62417025
134gene silencing by RNA (GO:0031047)2.60996597
135IMP biosynthetic process (GO:0006188)2.60907426
136intra-S DNA damage checkpoint (GO:0031573)2.60777391
137regulation of meiosis I (GO:0060631)2.60430719
138negative regulation of RNA splicing (GO:0033119)2.60053441
139* male meiosis I (GO:0007141)2.58229214
140cell differentiation in spinal cord (GO:0021515)2.57388907
141base-excision repair, AP site formation (GO:0006285)2.57071667
142negative regulation of telomere maintenance (GO:0032205)2.56934402
143histone H4 deacetylation (GO:0070933)2.56467209
144purine nucleobase biosynthetic process (GO:0009113)2.56425632
145DNA conformation change (GO:0071103)2.56323948
146regulation of collateral sprouting (GO:0048670)2.56140177
147transcription-coupled nucleotide-excision repair (GO:0006283)2.56137824
148left/right axis specification (GO:0070986)2.54599680
149deoxyribose phosphate catabolic process (GO:0046386)2.52905989
150response to interferon-beta (GO:0035456)2.51562978
151positive regulation of B cell differentiation (GO:0045579)2.50672374
152forebrain morphogenesis (GO:0048853)2.49924591
153cranial nerve morphogenesis (GO:0021602)2.46906326
154positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43643732
155dendritic spine morphogenesis (GO:0060997)2.43358152
156positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.43335819
157regulation of respiratory system process (GO:0044065)2.41720887
158mRNA splice site selection (GO:0006376)2.39989623
159positive regulation of protein homooligomerization (GO:0032464)2.37346653
160ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.36795448
161positive regulation of lymphocyte apoptotic process (GO:0070230)2.36172556
162olfactory bulb development (GO:0021772)2.34629674
163immunoglobulin mediated immune response (GO:0016064)2.32642765
164brain morphogenesis (GO:0048854)2.32112529
165cilium morphogenesis (GO:0060271)2.31512958
166tolerance induction (GO:0002507)2.31430840
167preassembly of GPI anchor in ER membrane (GO:0016254)2.30945429
168pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.30599549
169postsynaptic membrane organization (GO:0001941)2.27138150
170microtubule severing (GO:0051013)2.25890700
171dosage compensation (GO:0007549)2.24058000
172synaptic transmission, cholinergic (GO:0007271)2.23662052
173urogenital system development (GO:0001655)2.23306620
174NIK/NF-kappaB signaling (GO:0038061)2.22735107
175central nervous system myelination (GO:0022010)2.21827293
176axon ensheathment in central nervous system (GO:0032291)2.21827293
177enteric nervous system development (GO:0048484)2.20362975
178negative regulation of cell killing (GO:0031342)2.20224209
179negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.20224209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.35361368
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.22342388
3E2F7_22180533_ChIP-Seq_HELA_Human4.73212754
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.87130377
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.80012101
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14056436
7IKZF1_21737484_ChIP-ChIP_HCT116_Human3.08666293
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.76326707
9SCL_19346495_ChIP-Seq_HPC-7_Human2.72870058
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51307922
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37639368
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32131194
13* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.25305368
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14159759
15BCL6_27268052_Chip-Seq_Bcells_Human2.14039881
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13360615
17GATA1_22025678_ChIP-Seq_K562_Human2.13066701
18XRN2_22483619_ChIP-Seq_HELA_Human2.11260762
19P68_20966046_ChIP-Seq_HELA_Human2.10798589
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09374513
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.08455727
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.03474510
23DROSHA_22980978_ChIP-Seq_HELA_Human1.99681318
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.97280730
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.96466543
26MYC_22102868_ChIP-Seq_BL_Human1.96084379
27LXR_22292898_ChIP-Seq_THP-1_Human1.90014542
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89862834
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88624237
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.84324597
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83367709
32CIITA_25753668_ChIP-Seq_RAJI_Human1.81465574
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81322628
34CTCF_27219007_Chip-Seq_Bcells_Human1.79694336
35REST_21632747_ChIP-Seq_MESCs_Mouse1.78059988
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76867363
37YY1_22570637_ChIP-Seq_MALME-3M_Human1.74435707
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71286087
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.70324458
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.69612783
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69570269
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69355644
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69355644
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69355644
45VDR_23849224_ChIP-Seq_CD4+_Human1.67978497
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.67505615
47IRF1_19129219_ChIP-ChIP_H3396_Human1.66869491
48BCOR_27268052_Chip-Seq_Bcells_Human1.66659571
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.65475269
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.63663139
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59149231
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57918229
53FOXP3_21729870_ChIP-Seq_TREG_Human1.57857115
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.57749699
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.57285512
56E2F1_20622854_ChIP-Seq_HELA_Human1.56586100
57GABP_19822575_ChIP-Seq_HepG2_Human1.54772543
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54542570
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54203311
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54187619
61TTF2_22483619_ChIP-Seq_HELA_Human1.53812955
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53600458
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53105428
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51959991
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51361841
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51056877
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50968715
68DCP1A_22483619_ChIP-Seq_HELA_Human1.50179720
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49599076
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49593494
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49260823
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48957398
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48645197
74UTX_26944678_Chip-Seq_JUKART_Human1.48508986
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47736019
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47458803
77ZNF263_19887448_ChIP-Seq_K562_Human1.47446683
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46964768
79KDM2B_26808549_Chip-Seq_DND41_Human1.44809135
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44566126
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43752849
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.43393670
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41147853
84* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41033318
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40795740
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40721424
87SMC4_20622854_ChIP-Seq_HELA_Human1.40570526
88P300_27268052_Chip-Seq_Bcells_Human1.39251788
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37581353
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36607444
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33035152
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33012959
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32740701
94* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.32392603
95EGR1_19374776_ChIP-ChIP_THP-1_Human1.32196828
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32133438
97JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31530206
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.31459195
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31077299
100* SA1_27219007_Chip-Seq_Bcells_Human1.29021193
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.28680541
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26643553
103* MAF_26560356_Chip-Seq_TH2_Human1.25999673
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25952339
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25810795
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.24324797
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24247362
108TCF7_22412390_ChIP-Seq_EML_Mouse1.23760802
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23695929
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23496678
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23321622
112TFEB_21752829_ChIP-Seq_HELA_Human1.22289006
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21695261
114E2F1_21310950_ChIP-Seq_MCF-7_Human1.21566736
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21429007
116NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20675213
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19862432
118* MAF_26560356_Chip-Seq_TH1_Human1.19256692
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18901797
120KDM5A_27292631_Chip-Seq_BREAST_Human1.18656035
121YY1_21170310_ChIP-Seq_MESCs_Mouse1.18144621
122ZNF274_21170338_ChIP-Seq_K562_Hela1.18029122
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17415673
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16839886
125HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16156859
126RARB_24833708_ChIP-Seq_LIVER_Mouse1.15962901
127EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15253084
128OCT4_19829295_ChIP-Seq_ESCs_Human1.14969186
129* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14612446
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14375470
131CTCF_20526341_ChIP-Seq_ESCs_Human1.14244099
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14197099
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14185593
134ERA_21632823_ChIP-Seq_H3396_Human1.13899498
135TP63_19390658_ChIP-ChIP_HaCaT_Human1.12133084
136RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12052315
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10117339
138CTCF_26484167_Chip-Seq_Bcells_Mouse1.10016173
139SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.09035533
140RNF2_27304074_Chip-Seq_ESCs_Mouse1.08878641
141VDR_21846776_ChIP-Seq_THP-1_Human1.08731763
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08446805
143KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08167024
144LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07327917
145* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07325784
146PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07079263
147NANOG_20526341_ChIP-Seq_ESCs_Human1.06679626
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06500573
149* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05881914
150CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05800704
151TET1_21451524_ChIP-Seq_MESCs_Mouse1.05725461
152ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04035322
153VDR_24763502_ChIP-Seq_THP-1_Human1.03154409
154ELF1_20517297_ChIP-Seq_JURKAT_Human1.02839650
155CBX2_27304074_Chip-Seq_ESCs_Mouse1.02667489
156CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02066768
157CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01313661
158KDM2B_26808549_Chip-Seq_JURKAT_Human1.00591886
159CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00061194
160TAF2_19829295_ChIP-Seq_ESCs_Human0.99644499
161WDR5_24793694_ChIP-Seq_LNCAP_Human0.99616954
162AR_21909140_ChIP-Seq_LNCAP_Human0.99359664
163SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99165601
164RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97241851
165NCOR1_26117541_ChIP-Seq_K562_Human0.97227354
166TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97078044
167RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97004975
168RUNX1_22412390_ChIP-Seq_EML_Mouse0.95450382
169PHF8_20622854_ChIP-Seq_HELA_Human0.95241291
170RING1B_27294783_Chip-Seq_ESCs_Mouse0.95053458
171KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94849303
172BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93740738
173NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92711624
174FOXP1_21924763_ChIP-Seq_HESCs_Human0.92704089
175SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92022521
176MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91457756
177* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91261798
178HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90055752
179CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89061042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.47263234
2MP0002822_catalepsy3.27378058
3MP0008058_abnormal_DNA_repair2.96519706
4MP0005394_taste/olfaction_phenotype2.88308502
5MP0005499_abnormal_olfactory_system2.88308502
6MP0004957_abnormal_blastocyst_morpholog2.86901968
7MP0010094_abnormal_chromosome_stability2.76579666
8MP0010234_abnormal_vibrissa_follicle2.74714423
9MP0008789_abnormal_olfactory_epithelium2.73383886
10MP0008877_abnormal_DNA_methylation2.64750035
11MP0003122_maternal_imprinting2.57848427
12MP0008057_abnormal_DNA_replication2.48904878
13* MP0001929_abnormal_gametogenesis2.45211618
14MP0003693_abnormal_embryo_hatching2.38975855
15MP0002877_abnormal_melanocyte_morpholog2.35991685
16MP0004147_increased_porphyrin_level2.35679024
17MP0003941_abnormal_skin_development2.35618726
18MP0003111_abnormal_nucleus_morphology2.34269100
19MP0004264_abnormal_extraembryonic_tissu2.30623832
20MP0005645_abnormal_hypothalamus_physiol2.29355099
21MP0003880_abnormal_central_pattern2.21864811
22MP0006276_abnormal_autonomic_nervous2.20803614
23MP0003786_premature_aging2.19364526
24MP0005397_hematopoietic_system_phenotyp2.18685634
25MP0001545_abnormal_hematopoietic_system2.18685634
26* MP0003698_abnormal_male_reproductive2.15334025
27MP0003077_abnormal_cell_cycle2.09805658
28MP0004808_abnormal_hematopoietic_stem2.09746806
29MP0003866_abnormal_defecation2.03515909
30MP0008007_abnormal_cellular_replicative2.03342913
31* MP0002210_abnormal_sex_determination2.00093973
32* MP0001145_abnormal_male_reproductive1.97769442
33MP0003123_paternal_imprinting1.96403398
34MP0002396_abnormal_hematopoietic_system1.95067995
35MP0005174_abnormal_tail_pigmentation1.93756488
36MP0008995_early_reproductive_senescence1.89400827
37MP0000778_abnormal_nervous_system1.88341258
38MP0001986_abnormal_taste_sensitivity1.84799977
39MP0010307_abnormal_tumor_latency1.82089661
40* MP0000653_abnormal_sex_gland1.78702798
41MP0000490_abnormal_crypts_of1.76439543
42MP0004043_abnormal_pH_regulation1.74980313
43MP0002653_abnormal_ependyma_morphology1.74484432
44MP0002796_impaired_skin_barrier1.73717268
45MP0003283_abnormal_digestive_organ1.72854187
46MP0001984_abnormal_olfaction1.69426754
47MP0002638_abnormal_pupillary_reflex1.68805675
48MP0005423_abnormal_somatic_nervous1.68355847
49MP0003119_abnormal_digestive_system1.66719104
50MP0002938_white_spotting1.61418236
51MP0005501_abnormal_skin_physiology1.57554900
52MP0000678_abnormal_parathyroid_gland1.57414031
53MP0002928_abnormal_bile_duct1.56788650
54MP0003806_abnormal_nucleotide_metabolis1.48470019
55MP0004859_abnormal_synaptic_plasticity1.47489247
56MP0003878_abnormal_ear_physiology1.47038064
57MP0005377_hearing/vestibular/ear_phenot1.47038064
58MP0006054_spinal_hemorrhage1.45741967
59MP0009379_abnormal_foot_pigmentation1.44453335
60MP0000350_abnormal_cell_proliferation1.39527787
61MP0004142_abnormal_muscle_tone1.38414305
62MP0001529_abnormal_vocalization1.34536488
63MP0001293_anophthalmia1.30481655
64MP0001730_embryonic_growth_arrest1.30176115
65MP0002557_abnormal_social/conspecific_i1.29778205
66MP0002735_abnormal_chemical_nociception1.28541632
67MP0005075_abnormal_melanosome_morpholog1.26757642
68MP0003436_decreased_susceptibility_to1.25004455
69MP0001970_abnormal_pain_threshold1.24902975
70MP0006292_abnormal_olfactory_placode1.23439506
71MP0000313_abnormal_cell_death1.23392080
72MP0002084_abnormal_developmental_patter1.23181979
73MP0000631_abnormal_neuroendocrine_gland1.22540809
74MP0001790_abnormal_immune_system1.19806455
75MP0005387_immune_system_phenotype1.19806455
76* MP0004197_abnormal_fetal_growth/weight/1.18914669
77MP0002751_abnormal_autonomic_nervous1.18081303
78MP0002733_abnormal_thermal_nociception1.18021995
79MP0003567_abnormal_fetal_cardiomyocyte1.17473735
80* MP0002080_prenatal_lethality1.16527509
81MP0001800_abnormal_humoral_immune1.15119953
82* MP0002161_abnormal_fertility/fecundity1.15058062
83MP0003724_increased_susceptibility_to1.14859408
84MP0003315_abnormal_perineum_morphology1.14455165
85MP0001697_abnormal_embryo_size1.13440233
86MP0003303_peritoneal_inflammation1.12916110
87MP0000462_abnormal_digestive_system1.12722522
88MP0001666_abnormal_nutrient_absorption1.11038312
89MP0002909_abnormal_adrenal_gland1.10317749
90MP0002063_abnormal_learning/memory/cond1.09970743
91MP0004858_abnormal_nervous_system1.09778723
92MP0000955_abnormal_spinal_cord1.09745944
93MP0001835_abnormal_antigen_presentation1.09741718
94MP0005084_abnormal_gallbladder_morpholo1.09389346
95MP0003635_abnormal_synaptic_transmissio1.07782733
96MP0002572_abnormal_emotion/affect_behav1.07295774
97MP0005025_abnormal_response_to1.03482047
98MP0008932_abnormal_embryonic_tissue1.02254443
99MP0002086_abnormal_extraembryonic_tissu1.02138055
100MP0005551_abnormal_eye_electrophysiolog1.00615412
101MP0004811_abnormal_neuron_physiology1.00539731
102MP0001873_stomach_inflammation0.99825728
103MP0002882_abnormal_neuron_morphology0.99083729
104MP0002272_abnormal_nervous_system0.98309215
105MP0001968_abnormal_touch/_nociception0.98277005
106MP0010352_gastrointestinal_tract_polyps0.98047155
107MP0000477_abnormal_intestine_morphology0.97996223
108MP0001849_ear_inflammation0.97617942
109MP0002019_abnormal_tumor_incidence0.97501081
110MP0002163_abnormal_gland_morphology0.96875305
111MP0000049_abnormal_middle_ear0.96610467
112MP0002085_abnormal_embryonic_tissue0.96431235
113MP0003121_genomic_imprinting0.96239326
114MP0002734_abnormal_mechanical_nocicepti0.95793855
115MP0002095_abnormal_skin_pigmentation0.95043999
116MP0000465_gastrointestinal_hemorrhage0.94288587
117MP0002132_abnormal_respiratory_system0.94020288
118MP0001672_abnormal_embryogenesis/_devel0.93814777
119MP0005380_embryogenesis_phenotype0.93814777
120MP0003656_abnormal_erythrocyte_physiolo0.93265419
121MP0002752_abnormal_somatic_nervous0.93146748
122MP0009745_abnormal_behavioral_response0.92656763
123MP0005646_abnormal_pituitary_gland0.91904158
124MP0001905_abnormal_dopamine_level0.90276047
125MP0000681_abnormal_thyroid_gland0.89780149
126MP0003943_abnormal_hepatobiliary_system0.89619982
127MP0005367_renal/urinary_system_phenotyp0.89456657
128MP0000516_abnormal_urinary_system0.89456657
129MP0003787_abnormal_imprinting0.89347597
130MP0002184_abnormal_innervation0.89097750
131MP0000566_synostosis0.88146410
132MP0008961_abnormal_basal_metabolism0.87893432
133MP0005253_abnormal_eye_physiology0.87784399
134MP0006072_abnormal_retinal_apoptosis0.87396512
135MP0002723_abnormal_immune_serum0.87218532
136MP0005083_abnormal_biliary_tract0.86397077
137MP0002152_abnormal_brain_morphology0.86153691
138MP0000026_abnormal_inner_ear0.85801636
139MP0002420_abnormal_adaptive_immunity0.85491394
140MP0001819_abnormal_immune_cell0.84358665
141MP0002249_abnormal_larynx_morphology0.84057177
142MP0000537_abnormal_urethra_morphology0.82925552
143MP0005195_abnormal_posterior_eye0.80866269
144MP0009278_abnormal_bone_marrow0.80839880
145MP0005671_abnormal_response_to0.80308920
146MP0001944_abnormal_pancreas_morphology0.80260160
147MP0001188_hyperpigmentation0.80072741
148MP0003984_embryonic_growth_retardation0.79530152
149MP0002160_abnormal_reproductive_system0.78939696
150MP0002088_abnormal_embryonic_growth/wei0.78593299
151* MP0001119_abnormal_female_reproductive0.78538539
152MP0002452_abnormal_antigen_presenting0.78471234
153MP0000013_abnormal_adipose_tissue0.78339563
154MP0003861_abnormal_nervous_system0.77987981
155MP0001963_abnormal_hearing_physiology0.77286372
156MP0000358_abnormal_cell_content/0.76899200
157MP0005000_abnormal_immune_tolerance0.75025090
158MP0005220_abnormal_exocrine_pancreas0.74761814
159MP0001485_abnormal_pinna_reflex0.74554799
160MP0000685_abnormal_immune_system0.74480540
161MP0005464_abnormal_platelet_physiology0.74267561
162MP0002693_abnormal_pancreas_physiology0.73381594
163MP0002234_abnormal_pharynx_morphology0.73220539
164MP0009046_muscle_twitch0.72780550
165MP0008875_abnormal_xenobiotic_pharmacok0.72088038
166MP0001486_abnormal_startle_reflex0.71821067
167MP0002398_abnormal_bone_marrow0.71661031
168MP0000613_abnormal_salivary_gland0.70193049
169MP0005391_vision/eye_phenotype0.70184170
170MP0000716_abnormal_immune_system0.70079660
171MP0004133_heterotaxia0.69948383
172MP0002277_abnormal_respiratory_mucosa0.69896135
173MP0002064_seizures0.68834729
174MP0006036_abnormal_mitochondrial_physio0.66859719
175MP0003300_gastrointestinal_ulcer0.66500456
176MP0005670_abnormal_white_adipose0.66346885
177MP0003183_abnormal_peptide_metabolism0.64539292

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.69137840
2Abnormal number of erythroid precursors (HP:0012131)5.47400428
3Poikiloderma (HP:0001029)4.31097267
4Reticulocytopenia (HP:0001896)4.18338831
5Absent/shortened dynein arms (HP:0200106)4.08810339
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.08810339
7Pancreatic fibrosis (HP:0100732)3.96633741
8Aplastic anemia (HP:0001915)3.91444762
9True hermaphroditism (HP:0010459)3.79257838
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.62141452
11Molar tooth sign on MRI (HP:0002419)3.57155274
12Abnormality of midbrain morphology (HP:0002418)3.57155274
13Thrombocytosis (HP:0001894)3.53293434
14Chronic bronchitis (HP:0004469)3.51991621
15Nephronophthisis (HP:0000090)3.48736711
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.47709261
17Occipital encephalocele (HP:0002085)3.39610181
18Abnormality of DNA repair (HP:0003254)3.37941176
19Elevated erythrocyte sedimentation rate (HP:0003565)3.35564154
20Recurrent sinusitis (HP:0011108)3.35094661
21Ependymoma (HP:0002888)3.33617433
22Entropion (HP:0000621)3.29391693
23Aplasia/Hypoplasia of the sacrum (HP:0008517)3.23912689
2411 pairs of ribs (HP:0000878)3.23793149
25Colon cancer (HP:0003003)3.19794771
26Pancreatic cysts (HP:0001737)3.18733851
27Pallor (HP:0000980)3.15194583
28Abnormality of the anterior horn cell (HP:0006802)3.05570359
29Degeneration of anterior horn cells (HP:0002398)3.05570359
30Chronic hepatic failure (HP:0100626)3.04597467
31Cystic liver disease (HP:0006706)3.01318838
32Gait imbalance (HP:0002141)2.97699999
33Medial flaring of the eyebrow (HP:0010747)2.93893668
34Macrocytic anemia (HP:0001972)2.92701462
35Abnormal respiratory motile cilium morphology (HP:0005938)2.91421350
36Abnormal respiratory epithelium morphology (HP:0012253)2.91421350
37Male infertility (HP:0003251)2.90834190
38Infertility (HP:0000789)2.88965114
39Gonadotropin excess (HP:0000837)2.82366981
40Congenital primary aphakia (HP:0007707)2.81586480
41Nasal polyposis (HP:0100582)2.76898721
42Myelodysplasia (HP:0002863)2.72848835
43Abnormality of the nasal mucosa (HP:0000433)2.71540257
44Nephrogenic diabetes insipidus (HP:0009806)2.70390084
45Failure to thrive in infancy (HP:0001531)2.70157991
46Tubulointerstitial nephritis (HP:0001970)2.68767638
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63652338
48Anencephaly (HP:0002323)2.59302084
49Polyphagia (HP:0002591)2.54875716
50Pili torti (HP:0003777)2.52015519
51Myokymia (HP:0002411)2.51590298
52Medulloblastoma (HP:0002885)2.50826849
53Postaxial foot polydactyly (HP:0001830)2.50808011
54Abnormal respiratory motile cilium physiology (HP:0012261)2.50336209
55Chronic otitis media (HP:0000389)2.48348825
56Abnormality of the renal medulla (HP:0100957)2.48336410
57Congenital hepatic fibrosis (HP:0002612)2.47388654
58Abnormality of reticulocytes (HP:0004312)2.45751866
59Panhypogammaglobulinemia (HP:0003139)2.45213220
60Retinal dysplasia (HP:0007973)2.41783841
61Prolonged bleeding time (HP:0003010)2.41391685
62Sclerocornea (HP:0000647)2.41339186
63Agammaglobulinemia (HP:0004432)2.40586480
64Amaurosis fugax (HP:0100576)2.39840011
65Biliary tract neoplasm (HP:0100574)2.36381201
66Hypoplasia of the pons (HP:0012110)2.35412978
67Abnormal rod and cone electroretinograms (HP:0008323)2.34836912
68Petechiae (HP:0000967)2.31889702
69Nonprogressive disorder (HP:0003680)2.29975188
70Rhinitis (HP:0012384)2.29513074
71Optic nerve coloboma (HP:0000588)2.29489827
72Absent thumb (HP:0009777)2.28957260
73Basal cell carcinoma (HP:0002671)2.26364978
74Missing ribs (HP:0000921)2.25295819
75Abnormal spermatogenesis (HP:0008669)2.24134605
76Myositis (HP:0100614)2.21353551
77Annular pancreas (HP:0001734)2.19894831
78Bronchitis (HP:0012387)2.19405105
79Neoplasm of the oral cavity (HP:0100649)2.17645883
80Bile duct proliferation (HP:0001408)2.17632151
81Abnormal biliary tract physiology (HP:0012439)2.17632151
82Neoplasm of the pancreas (HP:0002894)2.14619021
83Adenoma sebaceum (HP:0009720)2.14463668
84Angiofibromas (HP:0010615)2.14463668
85Volvulus (HP:0002580)2.14057795
86Agitation (HP:0000713)2.13255758
87Vaginal atresia (HP:0000148)2.12857277
88Stomatitis (HP:0010280)2.11779941
89Poikilocytosis (HP:0004447)2.11453299
90Acanthocytosis (HP:0001927)2.10432097
91Rib fusion (HP:0000902)2.09127868
92Aplasia/Hypoplasia of the spleen (HP:0010451)2.09076186
93Genital tract atresia (HP:0001827)2.08732346
94Microretrognathia (HP:0000308)2.06649116
95Prominent nose (HP:0000448)2.05868648
96Abnormal platelet function (HP:0011869)2.05280841
97Impaired platelet aggregation (HP:0003540)2.05280841
98Male pseudohermaphroditism (HP:0000037)2.01299682
99Asplenia (HP:0001746)2.00923577
100Type I transferrin isoform profile (HP:0003642)2.00304885
101Abnormality of the pons (HP:0007361)2.00037355
102Abnormality of the aortic arch (HP:0012303)1.99158942
103Retinitis pigmentosa (HP:0000510)1.99122510
104Poor coordination (HP:0002370)1.98594230
105Atelectasis (HP:0100750)1.98558338
106Chronic sinusitis (HP:0011109)1.96684980
107Broad palm (HP:0001169)1.96455360
108Neoplasm of the rectum (HP:0100743)1.95858175
109Rough bone trabeculation (HP:0100670)1.95834586
110Severe visual impairment (HP:0001141)1.95176488
111Birth length less than 3rd percentile (HP:0003561)1.93743803
112Death in childhood (HP:0003819)1.91868574
113Muscle fiber atrophy (HP:0100295)1.91673302
114Fetal akinesia sequence (HP:0001989)1.89439449
115Chronic obstructive pulmonary disease (HP:0006510)1.89431512
116Obstructive lung disease (HP:0006536)1.89431512
117Abnormal biliary tract morphology (HP:0012440)1.89351069
118Supernumerary spleens (HP:0009799)1.88671929
119Bony spicule pigmentary retinopathy (HP:0007737)1.88511401
120Prominent metopic ridge (HP:0005487)1.88402290
121Recurrent otitis media (HP:0000403)1.87945031
122Abolished electroretinogram (ERG) (HP:0000550)1.83719933
123Anomalous pulmonary venous return (HP:0010772)1.83498014
124Hyperthyroidism (HP:0000836)1.83037338
125Specific learning disability (HP:0001328)1.82792927
126Oral leukoplakia (HP:0002745)1.82410048
127Abnormality of the astrocytes (HP:0100707)1.81356142
128Astrocytoma (HP:0009592)1.81356142
129Breast hypoplasia (HP:0003187)1.79090121
130Amblyopia (HP:0000646)1.78521990
131Overlapping toe (HP:0001845)1.76445571
132Bronchiectasis (HP:0002110)1.76301599
133Pancytopenia (HP:0001876)1.76012857
134Stenosis of the external auditory canal (HP:0000402)1.75891404
135Hypoplasia of the radius (HP:0002984)1.75220815
136Heterotopia (HP:0002282)1.74932914
137Micronodular cirrhosis (HP:0001413)1.74925423
138Abnormality of the parathyroid morphology (HP:0011766)1.74567185
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.74548478
140Germ cell neoplasia (HP:0100728)1.74131972
141Preaxial hand polydactyly (HP:0001177)1.73866055
142Abnormal ciliary motility (HP:0012262)1.73138420
143Postaxial hand polydactyly (HP:0001162)1.72435914
144Abnormality of the labia minora (HP:0012880)1.72329183
145Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71820385
146Depressed nasal ridge (HP:0000457)1.71238380
147Polydipsia (HP:0001959)1.70684062
148Abnormal drinking behavior (HP:0030082)1.70684062
149Neoplasm of the small intestine (HP:0100833)1.70425996
150Generalized aminoaciduria (HP:0002909)1.69743204
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.69499636
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69273545
153Abnormal protein N-linked glycosylation (HP:0012347)1.69273545
154Abnormal protein glycosylation (HP:0012346)1.69273545
155Abnormal glycosylation (HP:0012345)1.69273545
156Bone marrow hypocellularity (HP:0005528)1.68207475
157Abnormality of the fingertips (HP:0001211)1.67512907
158Oligodactyly (HP:0012165)1.67198131
159Abnormality of the preputium (HP:0100587)1.67053194
160Cortical visual impairment (HP:0100704)1.66245696
161Tubular atrophy (HP:0000092)1.65905808
162Neoplasm of the colon (HP:0100273)1.65311108
163Encephalitis (HP:0002383)1.65155757
164Type 2 muscle fiber atrophy (HP:0003554)1.64777048
165Narrow forehead (HP:0000341)1.63372649
166Holoprosencephaly (HP:0001360)1.63012270
167IgM deficiency (HP:0002850)1.59565387
168Episodic fever (HP:0001954)1.59468944
169Abnormal hair laboratory examination (HP:0003328)1.58775471
170Neoplasm of striated muscle (HP:0009728)1.58106535
171Mediastinal lymphadenopathy (HP:0100721)1.56967745
172Lissencephaly (HP:0001339)1.53646143
173Aganglionic megacolon (HP:0002251)1.53520296
174Recurrent abscess formation (HP:0002722)1.53509545
175Nephropathy (HP:0000112)1.53130434

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.02034593
2BRD43.69806237
3MAPK153.38279812
4EEF2K3.18046426
5RPS6KB22.86043339
6DYRK22.63987485
7WEE12.52672450
8TGFBR12.45732527
9MAP2K32.42440663
10NEK22.41763652
11PASK2.35013946
12DYRK32.13957671
13MAP4K22.08073181
14PDK42.05241797
15PDK32.05241797
16ACVR1B2.02571537
17CDK71.87422854
18CDC71.85238938
19SIK21.84097704
20CDK191.75005253
21ERN11.74149304
22NTRK21.73842676
23TNK21.65594032
24MAP2K71.60847517
25EPHA21.55670060
26MAP2K61.52369842
27CDK91.50306727
28MARK11.49125541
29EPHA31.48136401
30ICK1.46301221
31FES1.45335546
32PAK41.43896678
33MKNK11.42959223
34STK161.42188365
35VRK21.41335619
36FLT31.37953999
37MARK21.31493093
38TBK11.28775053
39PRKD31.24713429
40TAOK11.24295503
41BUB11.23489165
42NME21.22909803
43PRKD21.20135948
44RPS6KC11.19210322
45RPS6KL11.19210322
46SCYL21.16224730
47TTK1.16096541
48RPS6KA61.16048073
49CSNK1G31.15686860
50MAPK131.14954293
51SYK1.14356909
52RPS6KA21.14115167
53TAF11.14058703
54SRPK11.13596052
55SMG11.13128584
56CSNK1G21.10258430
57DAPK21.09558471
58BRSK21.07764310
59ATR1.07523608
60TIE11.05656914
61DYRK1A1.05634167
62MATK1.03848092
63GRK61.02785661
64MAP3K31.02603632
65IKBKE1.02318713
66HIPK21.00147863
67MKNK21.00111614
68MAP2K40.99762974
69MAP3K100.99339428
70BTK0.98850961
71MAP3K70.98528102
72MAP3K40.95240591
73STK110.95111537
74MAPKAPK30.94660694
75TYRO30.94535836
76CDK40.91076442
77PRKG20.89573401
78CSNK1G10.87639147
79PINK10.87473918
80MAP3K80.86973177
81ZAP700.86870231
82PLK10.86604233
83CSF1R0.86217576
84PRKCI0.85936185
85AKT30.85272179
86TYK20.84735847
87PRKCQ0.84699422
88ITK0.84484996
89IKBKB0.83916773
90GRK10.83671019
91CDK80.82860855
92PRKCH0.81998579
93SGK2230.81767967
94SGK4940.81767967
95TSSK60.81083355
96TESK10.80641955
97UHMK10.80328841
98MST40.80113046
99MAP2K20.80097753
100PDK20.78896633
101BCKDK0.78198214
102STK40.77609010
103CASK0.77231094
104MAP3K120.76606412
105LYN0.74976857
106VRK10.74685912
107CHEK20.74560852
108TAOK30.74001056
109CDK60.73366824
110CSNK1A1L0.72882442
111DAPK10.71980774
112TEC0.71827803
113LCK0.71667691
114PTK60.71587255
115KIT0.71331686
116TESK20.70976007
117CHEK10.69758277
118MAP3K110.69689060
119PKN10.69654107
120IRAK40.69354097
121LRRK20.68551507
122CSK0.68081008
123MTOR0.66722780
124PRKCZ0.66148484
125DDR20.66121860
126BLK0.65405955
127TRIM280.62960540
128EPHB10.62177618
129ATM0.61332658
130CAMKK20.60744407
131PIM10.59943765
132DYRK1B0.59471980
133NUAK10.59131706
134RPS6KB10.57503196
135CAMKK10.57174612
136MUSK0.56954899
137PIM20.56835368
138CAMK1D0.56829637
139CDK20.56545594
140AURKB0.55553609
141ALK0.53993933
142MAPKAPK50.53756163
143TXK0.53743763
144EPHB20.53149000
145SGK20.52135641
146AURKA0.51154106
147MAP3K60.50957739
148STK100.50588096
149MINK10.50461733
150MAP4K10.50193669
151PTK20.49685951
152CSNK2A20.49196915
153ADRBK20.48857109
154CAMK10.48839115
155FGR0.48776349
156WNK30.48527601
157HCK0.47830534
158TNIK0.47721960
159CDK50.46456270
160MAPK70.46314498
161RIPK40.45348649
162PRKCD0.45118731
163BCR0.44773779
164ERBB20.44113637
165EIF2AK10.43516014
166TGFBR20.42543228
167PLK40.41587272
168PRKDC0.39132735
169BRAF0.38823267
170JAK30.35767401
171RPS6KA40.35326045
172PNCK0.34556498
173PAK20.34230614
174IRAK30.33619433
175MAPK10.32135500
176PKN20.31851084

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.57344359
2DNA replication_Homo sapiens_hsa030304.11680054
3Mismatch repair_Homo sapiens_hsa034304.09451889
4Nucleotide excision repair_Homo sapiens_hsa034203.06337427
5Primary immunodeficiency_Homo sapiens_hsa053402.77835373
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.63704286
7Basal transcription factors_Homo sapiens_hsa030222.53719545
8RNA transport_Homo sapiens_hsa030132.52643633
9Allograft rejection_Homo sapiens_hsa053302.51605674
10Spliceosome_Homo sapiens_hsa030402.46917280
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.44391092
12RNA polymerase_Homo sapiens_hsa030202.38051979
13Homologous recombination_Homo sapiens_hsa034402.36092347
14Base excision repair_Homo sapiens_hsa034102.35551198
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33294106
16Asthma_Homo sapiens_hsa053102.28221146
17Type I diabetes mellitus_Homo sapiens_hsa049402.23048165
18Autoimmune thyroid disease_Homo sapiens_hsa053202.18129121
19Intestinal immune network for IgA production_Homo sapiens_hsa046722.18051900
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13339008
21Graft-versus-host disease_Homo sapiens_hsa053322.10868665
22Pyrimidine metabolism_Homo sapiens_hsa002402.04972758
23mRNA surveillance pathway_Homo sapiens_hsa030152.00904339
24Fructose and mannose metabolism_Homo sapiens_hsa000512.00736122
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99619080
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.90639804
27Fanconi anemia pathway_Homo sapiens_hsa034601.79406739
28Cell cycle_Homo sapiens_hsa041101.76832765
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67430669
30Non-homologous end-joining_Homo sapiens_hsa034501.55223421
31Phototransduction_Homo sapiens_hsa047441.51995767
32Folate biosynthesis_Homo sapiens_hsa007901.50857171
33Protein export_Homo sapiens_hsa030601.50737325
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48891503
35RNA degradation_Homo sapiens_hsa030181.45163156
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43649730
37Selenocompound metabolism_Homo sapiens_hsa004501.42829842
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37503389
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37057216
40Fat digestion and absorption_Homo sapiens_hsa049751.36743965
41Regulation of autophagy_Homo sapiens_hsa041401.35529942
42Leishmaniasis_Homo sapiens_hsa051401.34950154
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30978811
44Huntingtons disease_Homo sapiens_hsa050161.29346041
45Basal cell carcinoma_Homo sapiens_hsa052171.25530528
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.23515059
47One carbon pool by folate_Homo sapiens_hsa006701.23297928
48p53 signaling pathway_Homo sapiens_hsa041151.23145373
49Galactose metabolism_Homo sapiens_hsa000521.22569245
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22028837
51Hedgehog signaling pathway_Homo sapiens_hsa043401.19491293
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.19330540
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19042300
54Thyroid cancer_Homo sapiens_hsa052161.17880722
55Proteasome_Homo sapiens_hsa030501.15989099
56Nicotine addiction_Homo sapiens_hsa050331.12587223
57Axon guidance_Homo sapiens_hsa043601.11600093
58Purine metabolism_Homo sapiens_hsa002301.09632009
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08990001
60Peroxisome_Homo sapiens_hsa041461.07914319
61Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03784598
62Staphylococcus aureus infection_Homo sapiens_hsa051501.03309042
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02904267
64N-Glycan biosynthesis_Homo sapiens_hsa005100.99247364
65Linoleic acid metabolism_Homo sapiens_hsa005910.97860516
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96360002
67Parkinsons disease_Homo sapiens_hsa050120.95548189
68Viral myocarditis_Homo sapiens_hsa054160.90956550
69Oxidative phosphorylation_Homo sapiens_hsa001900.90939022
70Antigen processing and presentation_Homo sapiens_hsa046120.90783058
71Pentose phosphate pathway_Homo sapiens_hsa000300.90424233
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88148912
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87668222
74Ether lipid metabolism_Homo sapiens_hsa005650.87345666
75Morphine addiction_Homo sapiens_hsa050320.86018800
76Renin-angiotensin system_Homo sapiens_hsa046140.85938796
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85046738
78Cocaine addiction_Homo sapiens_hsa050300.83500504
79Acute myeloid leukemia_Homo sapiens_hsa052210.83252728
80Tuberculosis_Homo sapiens_hsa051520.80010573
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79686897
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79526640
83Herpes simplex infection_Homo sapiens_hsa051680.77189471
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76317676
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75546029
86Arachidonic acid metabolism_Homo sapiens_hsa005900.75374280
87Butanoate metabolism_Homo sapiens_hsa006500.75161843
88Influenza A_Homo sapiens_hsa051640.73491547
89Olfactory transduction_Homo sapiens_hsa047400.72277773
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71393690
91Epstein-Barr virus infection_Homo sapiens_hsa051690.70684286
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69590840
93* Oocyte meiosis_Homo sapiens_hsa041140.69573110
94Collecting duct acid secretion_Homo sapiens_hsa049660.69347449
95Osteoclast differentiation_Homo sapiens_hsa043800.69248211
96Synaptic vesicle cycle_Homo sapiens_hsa047210.68822204
97Cholinergic synapse_Homo sapiens_hsa047250.68806203
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68665942
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66009614
100Hematopoietic cell lineage_Homo sapiens_hsa046400.63758923
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63245563
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.63061491
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62862319
104Steroid biosynthesis_Homo sapiens_hsa001000.62251500
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62004680
106GABAergic synapse_Homo sapiens_hsa047270.61569478
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60536558
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.60264666
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.60124096
110Inositol phosphate metabolism_Homo sapiens_hsa005620.59292306
111Caffeine metabolism_Homo sapiens_hsa002320.58618014
112Lysine degradation_Homo sapiens_hsa003100.58594988
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57733534
114Glycerolipid metabolism_Homo sapiens_hsa005610.56359521
115Circadian entrainment_Homo sapiens_hsa047130.55474751
116AMPK signaling pathway_Homo sapiens_hsa041520.55117219
117Viral carcinogenesis_Homo sapiens_hsa052030.54511854
118mTOR signaling pathway_Homo sapiens_hsa041500.52176524
119Hepatitis C_Homo sapiens_hsa051600.50469134
120Chemical carcinogenesis_Homo sapiens_hsa052040.50252674
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50124900
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49733776
123ABC transporters_Homo sapiens_hsa020100.48977644
124Taste transduction_Homo sapiens_hsa047420.48349692
125Fatty acid metabolism_Homo sapiens_hsa012120.48205901
126Rheumatoid arthritis_Homo sapiens_hsa053230.48135905
127Phagosome_Homo sapiens_hsa041450.47969312
128Chemokine signaling pathway_Homo sapiens_hsa040620.47321713
129Dopaminergic synapse_Homo sapiens_hsa047280.47078326
130Biosynthesis of amino acids_Homo sapiens_hsa012300.46374536
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44917924
132Measles_Homo sapiens_hsa051620.44472469
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44328480
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43108018
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43078553
136Platelet activation_Homo sapiens_hsa046110.42915103
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42661633
138Salmonella infection_Homo sapiens_hsa051320.42444318
139Glutamatergic synapse_Homo sapiens_hsa047240.42249642
140Bladder cancer_Homo sapiens_hsa052190.42151097
141Insulin secretion_Homo sapiens_hsa049110.41902823
142MAPK signaling pathway_Homo sapiens_hsa040100.41620433
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41509039
144Glutathione metabolism_Homo sapiens_hsa004800.41337411
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41213187
146Pyruvate metabolism_Homo sapiens_hsa006200.41013628
147Retinol metabolism_Homo sapiens_hsa008300.40763836
148Vitamin digestion and absorption_Homo sapiens_hsa049770.40464373
149Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40189783
150Thyroid hormone synthesis_Homo sapiens_hsa049180.39543495
151Protein digestion and absorption_Homo sapiens_hsa049740.39458848
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.37779414
153Sulfur relay system_Homo sapiens_hsa041220.37136621
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36338378
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35173203
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33430709
157Notch signaling pathway_Homo sapiens_hsa043300.31336327
158Glucagon signaling pathway_Homo sapiens_hsa049220.31235747
159Non-small cell lung cancer_Homo sapiens_hsa052230.30776193
160HTLV-I infection_Homo sapiens_hsa051660.30512365
161Chronic myeloid leukemia_Homo sapiens_hsa052200.28061648
162Neurotrophin signaling pathway_Homo sapiens_hsa047220.26790990
163Carbon metabolism_Homo sapiens_hsa012000.26313296
164B cell receptor signaling pathway_Homo sapiens_hsa046620.26088993
165Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26053109
166Metabolic pathways_Homo sapiens_hsa011000.25403439
167Sphingolipid metabolism_Homo sapiens_hsa006000.25133839
168Alcoholism_Homo sapiens_hsa050340.24253932
169VEGF signaling pathway_Homo sapiens_hsa043700.23585811
170Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22388329
171Pancreatic secretion_Homo sapiens_hsa049720.21490410
172Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19509868

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