RDM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.71042779
2sister chromatid segregation (GO:0000819)5.39715913
3ribosomal small subunit assembly (GO:0000028)5.09950020
4maturation of SSU-rRNA (GO:0030490)4.95035140
5microtubule depolymerization (GO:0007019)4.69471449
6viral transcription (GO:0019083)4.48721658
7ribosomal small subunit biogenesis (GO:0042274)4.42195523
8mitotic chromosome condensation (GO:0007076)4.41891238
9formation of translation preinitiation complex (GO:0001731)4.37205634
10telomere maintenance via semi-conservative replication (GO:0032201)4.35804860
11DNA strand elongation involved in DNA replication (GO:0006271)4.35490467
12translational termination (GO:0006415)4.33589752
13DNA strand elongation (GO:0022616)4.14772757
14kinetochore assembly (GO:0051382)4.09140858
15kinetochore organization (GO:0051383)4.00983186
16DNA replication checkpoint (GO:0000076)3.97860639
17DNA replication initiation (GO:0006270)3.97360856
18protein K6-linked ubiquitination (GO:0085020)3.95722671
19translational elongation (GO:0006414)3.92815482
20telomere maintenance via recombination (GO:0000722)3.91554694
21resolution of meiotic recombination intermediates (GO:0000712)3.90408617
22ribosomal large subunit biogenesis (GO:0042273)3.87665538
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.85654037
24ribonucleoprotein complex biogenesis (GO:0022613)3.85605321
25mitotic metaphase plate congression (GO:0007080)3.84486622
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80851133
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.80851133
28CENP-A containing nucleosome assembly (GO:0034080)3.74546165
29translational initiation (GO:0006413)3.74466920
30ribosome biogenesis (GO:0042254)3.71134398
31chromatin remodeling at centromere (GO:0031055)3.69203228
32chromosome condensation (GO:0030261)3.67886418
33spindle checkpoint (GO:0031577)3.65393046
34chromosome segregation (GO:0007059)3.62117507
35attachment of spindle microtubules to kinetochore (GO:0008608)3.58844295
36regulation of chromosome segregation (GO:0051983)3.56703623
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56066087
38mitotic recombination (GO:0006312)3.53105649
39telomere maintenance via telomere lengthening (GO:0010833)3.49702069
40establishment of integrated proviral latency (GO:0075713)3.45803351
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45481245
42regulation of gene silencing by RNA (GO:0060966)3.45146440
43regulation of posttranscriptional gene silencing (GO:0060147)3.45146440
44regulation of gene silencing by miRNA (GO:0060964)3.45146440
45nucleobase biosynthetic process (GO:0046112)3.44048550
46microtubule polymerization or depolymerization (GO:0031109)3.41833837
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41520065
48negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.40503198
49negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.40503198
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.40503198
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.40503198
52negative regulation of sister chromatid segregation (GO:0033046)3.40503198
53DNA topological change (GO:0006265)3.39679540
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.39587436
55rRNA processing (GO:0006364)3.38852474
56viral life cycle (GO:0019058)3.38767512
57purine nucleobase biosynthetic process (GO:0009113)3.36930499
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.36819106
59cotranslational protein targeting to membrane (GO:0006613)3.36395621
60mitotic spindle checkpoint (GO:0071174)3.35971921
61replication fork processing (GO:0031297)3.35375050
62protein targeting to ER (GO:0045047)3.33896982
63proteasome assembly (GO:0043248)3.33564541
64metaphase plate congression (GO:0051310)3.33246645
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.33120633
66regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32182303
67regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32182303
68regulation of spindle organization (GO:0090224)3.30515014
69cellular protein complex disassembly (GO:0043624)3.29618791
70viral mRNA export from host cell nucleus (GO:0046784)3.28121706
71DNA packaging (GO:0006323)3.28117520
72mitotic spindle assembly checkpoint (GO:0007094)3.27938679
73synapsis (GO:0007129)3.27579882
74centriole replication (GO:0007099)3.26947936
75rRNA metabolic process (GO:0016072)3.25985670
76spindle assembly checkpoint (GO:0071173)3.25064089
77protein localization to chromosome (GO:0034502)3.24404655
78DNA replication-independent nucleosome organization (GO:0034724)3.23865390
79DNA replication-independent nucleosome assembly (GO:0006336)3.23865390
80regulation of sister chromatid segregation (GO:0033045)3.22849817
81regulation of mitotic sister chromatid separation (GO:0010965)3.22849817
82regulation of mitotic sister chromatid segregation (GO:0033047)3.22849817
83DNA double-strand break processing (GO:0000729)3.21791857
84mitotic sister chromatid segregation (GO:0000070)3.21484887
85DNA strand renaturation (GO:0000733)3.19955119
86transcription from mitochondrial promoter (GO:0006390)3.19151437
87proline biosynthetic process (GO:0006561)3.18126604
88establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14554931
89protein localization to endoplasmic reticulum (GO:0070972)3.14441601
90protein localization to chromosome, centromeric region (GO:0071459)3.14333427
91maturation of 5.8S rRNA (GO:0000460)3.14247922
92DNA unwinding involved in DNA replication (GO:0006268)3.11992489
93L-serine metabolic process (GO:0006563)3.10461471
94meiotic chromosome segregation (GO:0045132)3.09049750
95protein localization to kinetochore (GO:0034501)3.08784058
96deoxyribonucleotide biosynthetic process (GO:0009263)3.07994768
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07945990
98establishment of protein localization to mitochondrial membrane (GO:0090151)3.07248729
99negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.05866003
100mitotic nuclear envelope disassembly (GO:0007077)3.05748610
101regulation of centriole replication (GO:0046599)3.05688777
102rRNA modification (GO:0000154)3.04647463
103transcription-coupled nucleotide-excision repair (GO:0006283)3.03363378
104regulation of DNA endoreduplication (GO:0032875)3.02337403
105non-recombinational repair (GO:0000726)3.02275307
106double-strand break repair via nonhomologous end joining (GO:0006303)3.02275307
107IMP biosynthetic process (GO:0006188)3.00876248
108recombinational repair (GO:0000725)3.00764547
109establishment of chromosome localization (GO:0051303)3.00608446
110rRNA methylation (GO:0031167)2.98789767
111double-strand break repair via homologous recombination (GO:0000724)2.98677743
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97103268
113spliceosomal snRNP assembly (GO:0000387)2.96385039
114mismatch repair (GO:0006298)2.95942589
115mitotic cell cycle (GO:0000278)2.95853953
116DNA ligation (GO:0006266)2.95361671
117histone exchange (GO:0043486)2.94004709
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92871429
119protein complex disassembly (GO:0043241)2.92121725
120ATP synthesis coupled proton transport (GO:0015986)2.91897529
121energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91897529
122DNA replication-dependent nucleosome assembly (GO:0006335)2.91788859
123DNA replication-dependent nucleosome organization (GO:0034723)2.91788859
124regulation of mitochondrial translation (GO:0070129)2.91515158
125nuclear-transcribed mRNA catabolic process (GO:0000956)2.90933639
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.90507551
127chromatin assembly or disassembly (GO:0006333)2.89892920
128translation (GO:0006412)2.89315237
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87569872
130ATP-dependent chromatin remodeling (GO:0043044)2.86955762
131pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.86675107
132negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83861361
133regulation of mitotic spindle organization (GO:0060236)2.82598186
134cellular component biogenesis (GO:0044085)2.81910323
135pseudouridine synthesis (GO:0001522)2.78976100
136regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78470589
137telomere maintenance (GO:0000723)2.78452690
138telomere organization (GO:0032200)2.77995586
139mRNA catabolic process (GO:0006402)2.75750135
140ribosome assembly (GO:0042255)2.75011040
141macromolecular complex disassembly (GO:0032984)2.74621449
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74574794
143positive regulation of chromosome segregation (GO:0051984)2.74451085
144base-excision repair (GO:0006284)2.74367543
145termination of RNA polymerase I transcription (GO:0006363)2.74338123
146regulation of double-strand break repair via homologous recombination (GO:0010569)2.73990954
147transcription from RNA polymerase I promoter (GO:0006360)2.73708214
148oxidative phosphorylation (GO:0006119)2.73684362
149mitochondrial RNA metabolic process (GO:0000959)2.73174169
150negative regulation of chromosome segregation (GO:0051985)2.72642655
151nuclear envelope disassembly (GO:0051081)2.71571208
152membrane disassembly (GO:0030397)2.71571208
153transcription elongation from RNA polymerase III promoter (GO:0006385)2.69813644
154termination of RNA polymerase III transcription (GO:0006386)2.69813644
155RNA catabolic process (GO:0006401)2.69790368
156exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69355492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.25219873
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89718455
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.73013997
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23187879
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88777650
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83759289
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80033287
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76595560
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69335951
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67490115
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.59779845
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.55208103
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53917562
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35610438
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.35198787
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27577909
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25733436
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19176337
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.18326346
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07026544
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.04038344
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01228095
23* XRN2_22483619_ChIP-Seq_HELA_Human2.00181403
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99019931
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93654041
26VDR_23849224_ChIP-Seq_CD4+_Human1.89603274
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84927339
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84061861
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77469197
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76173027
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.71656791
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71606733
33MYC_18940864_ChIP-ChIP_HL60_Human1.70063525
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67706342
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67320947
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67320947
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67320947
38FOXP3_21729870_ChIP-Seq_TREG_Human1.66051608
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64074906
40DCP1A_22483619_ChIP-Seq_HELA_Human1.63527925
41AR_21909140_ChIP-Seq_LNCAP_Human1.61492442
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.61445392
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57294879
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57090057
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56454785
46GABP_19822575_ChIP-Seq_HepG2_Human1.54589705
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54298738
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49796275
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.49679354
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49497398
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48243473
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47052451
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45983334
54* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45422191
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44022154
56TTF2_22483619_ChIP-Seq_HELA_Human1.43996793
57EWS_26573619_Chip-Seq_HEK293_Human1.43811273
58IRF1_19129219_ChIP-ChIP_H3396_Human1.42827504
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.42702861
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41184693
61* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39133442
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.38275857
63MYC_22102868_ChIP-Seq_BL_Human1.35522429
64FUS_26573619_Chip-Seq_HEK293_Human1.30152541
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28827147
66ELK1_19687146_ChIP-ChIP_HELA_Human1.27061425
67SOX2_18692474_ChIP-Seq_MEFs_Mouse1.26726524
68CIITA_25753668_ChIP-Seq_RAJI_Human1.24085029
69VDR_21846776_ChIP-Seq_THP-1_Human1.22312074
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22243821
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21942912
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20661052
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18463525
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.18384592
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17600297
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17001551
77* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16767023
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16182436
79* KDM5A_27292631_Chip-Seq_BREAST_Human1.14647675
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.14630858
81IGF1R_20145208_ChIP-Seq_DFB_Human1.13748086
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13542012
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12985153
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.12675690
85* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11708535
86ZNF274_21170338_ChIP-Seq_K562_Hela1.11280202
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11074925
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09879683
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09153282
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08685121
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08660900
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.08574317
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06482245
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06304425
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05850037
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05579436
97NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03449319
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03319038
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01958713
100NANOG_21062744_ChIP-ChIP_HESCs_Human1.01532048
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01070764
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97492574
103NANOG_16153702_ChIP-ChIP_HESCs_Human0.96922596
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96641978
105SPI1_23547873_ChIP-Seq_NB4_Human0.94710783
106* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93535171
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93313185
108POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93063468
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92578249
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92475518
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92058642
112TFEB_21752829_ChIP-Seq_HELA_Human0.91532031
113SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90806264
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88306519
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87887673
116* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87666505
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.87650123
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82064864
119VDR_22108803_ChIP-Seq_LS180_Human0.79794168
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79289426
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77753916
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.73780464
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69613830
124POU3F2_20337985_ChIP-ChIP_501MEL_Human0.66995822
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.64806078
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.64668377
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.61590101
128SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.58610570
129SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.58292917
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.58057029
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.58003264
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.57567039
133FLI1_27457419_Chip-Seq_LIVER_Mouse0.56046932
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.55594675
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.55586400
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.54938997
137TP53_22573176_ChIP-Seq_HFKS_Human0.53007083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.87843988
2MP0010094_abnormal_chromosome_stability3.86871299
3MP0008057_abnormal_DNA_replication3.85345486
4MP0004957_abnormal_blastocyst_morpholog3.80512982
5MP0003111_abnormal_nucleus_morphology3.71609700
6MP0003077_abnormal_cell_cycle3.28489459
7MP0008058_abnormal_DNA_repair2.82788320
8MP0003786_premature_aging2.25944073
9MP0002234_abnormal_pharynx_morphology2.25867075
10MP0003806_abnormal_nucleotide_metabolis2.18652762
11MP0008007_abnormal_cellular_replicative2.14239427
12MP0008932_abnormal_embryonic_tissue2.10412737
13MP0002938_white_spotting2.02216949
14MP0003718_maternal_effect1.93567386
15MP0009697_abnormal_copulation1.91190204
16MP0003941_abnormal_skin_development1.88063342
17MP0002396_abnormal_hematopoietic_system1.87424088
18MP0000372_irregular_coat_pigmentation1.86624961
19MP0001730_embryonic_growth_arrest1.85141701
20MP0001529_abnormal_vocalization1.81966898
21MP0000490_abnormal_crypts_of1.73171546
22MP0000566_synostosis1.73084256
23MP0003763_abnormal_thymus_physiology1.70288400
24MP0000350_abnormal_cell_proliferation1.69104910
25MP0002163_abnormal_gland_morphology1.63178325
26MP0003186_abnormal_redox_activity1.60726572
27MP0006035_abnormal_mitochondrial_morpho1.57427820
28MP0000685_abnormal_immune_system1.56376591
29MP0010352_gastrointestinal_tract_polyps1.54761563
30MP0001853_heart_inflammation1.49621685
31MP0004133_heterotaxia1.47345646
32MP0002132_abnormal_respiratory_system1.44881197
33MP0003567_abnormal_fetal_cardiomyocyte1.44002879
34MP0001545_abnormal_hematopoietic_system1.38767205
35MP0005397_hematopoietic_system_phenotyp1.38767205
36MP0002019_abnormal_tumor_incidence1.36773777
37MP0001672_abnormal_embryogenesis/_devel1.35768661
38MP0005380_embryogenesis_phenotype1.35768661
39MP0001697_abnormal_embryo_size1.35612954
40MP0003698_abnormal_male_reproductive1.34455371
41MP0006072_abnormal_retinal_apoptosis1.34370260
42MP0008995_early_reproductive_senescence1.33807295
43MP0000313_abnormal_cell_death1.32526752
44MP0001346_abnormal_lacrimal_gland1.32334337
45MP0003937_abnormal_limbs/digits/tail_de1.31745735
46MP0006292_abnormal_olfactory_placode1.31614637
47MP0008789_abnormal_olfactory_epithelium1.29702379
48MP0009333_abnormal_splenocyte_physiolog1.28915621
49MP0002102_abnormal_ear_morphology1.28849795
50MP0009379_abnormal_foot_pigmentation1.26189722
51MP0002086_abnormal_extraembryonic_tissu1.24545436
52MP0002080_prenatal_lethality1.23677159
53MP0000647_abnormal_sebaceous_gland1.21725692
54MP0010307_abnormal_tumor_latency1.20919252
55MP0008877_abnormal_DNA_methylation1.20623063
56MP0000689_abnormal_spleen_morphology1.20537960
57MP0010030_abnormal_orbit_morphology1.20425836
58MP0005075_abnormal_melanosome_morpholog1.19800139
59MP0002722_abnormal_immune_system1.19050210
60MP0002009_preneoplasia1.17304453
61MP0002398_abnormal_bone_marrow1.15435804
62MP0003984_embryonic_growth_retardation1.15435467
63MP0009278_abnormal_bone_marrow1.14707144
64MP0002085_abnormal_embryonic_tissue1.14706023
65MP0003121_genomic_imprinting1.13666629
66MP0001835_abnormal_antigen_presentation1.13181969
67MP0002088_abnormal_embryonic_growth/wei1.12563750
68MP0001286_abnormal_eye_development1.11855394
69MP0004147_increased_porphyrin_level1.10866693
70MP0005187_abnormal_penis_morphology1.09308237
71MP0001984_abnormal_olfaction1.09027801
72MP0000049_abnormal_middle_ear1.08798036
73MP0003011_delayed_dark_adaptation1.07849517
74MP0005379_endocrine/exocrine_gland_phen1.05504407
75MP0001800_abnormal_humoral_immune1.04884383
76MP0002095_abnormal_skin_pigmentation1.04834946
77MP0003136_yellow_coat_color1.04134790
78MP0002697_abnormal_eye_size1.04044398
79MP0000703_abnormal_thymus_morphology1.03566470
80MP0002233_abnormal_nose_morphology1.03501427
81MP0001293_anophthalmia1.03056882
82MP0005394_taste/olfaction_phenotype1.02814528
83MP0005499_abnormal_olfactory_system1.02814528
84MP0002653_abnormal_ependyma_morphology1.02676875
85MP0005410_abnormal_fertilization1.01778984
86MP0002405_respiratory_system_inflammati1.01157109
87MP0005084_abnormal_gallbladder_morpholo0.99786261
88MP0005671_abnormal_response_to0.99514255
89MP0000631_abnormal_neuroendocrine_gland0.99503889
90MP0002429_abnormal_blood_cell0.98177794
91MP0002084_abnormal_developmental_patter0.96331884
92MP0004808_abnormal_hematopoietic_stem0.96185853
93MP0005253_abnormal_eye_physiology0.92919253
94MP0005266_abnormal_metabolism0.92396357
95MP0005501_abnormal_skin_physiology0.92204973
96MP0002166_altered_tumor_susceptibility0.92040358
97MP0003828_pulmonary_edema0.91976565
98MP0000716_abnormal_immune_system0.91891867
99MP0004197_abnormal_fetal_growth/weight/0.91856548
100MP0005023_abnormal_wound_healing0.91085045
101MP0006036_abnormal_mitochondrial_physio0.89065138
102MP0005248_abnormal_Harderian_gland0.87852594
103MP0002928_abnormal_bile_duct0.85426897
104MP0002796_impaired_skin_barrier0.85222518
105MP0002161_abnormal_fertility/fecundity0.84649057
106MP0005391_vision/eye_phenotype0.83985780
107MP0003123_paternal_imprinting0.83531844
108MP0002210_abnormal_sex_determination0.83146124
109MP0002282_abnormal_trachea_morphology0.83122990
110MP0002160_abnormal_reproductive_system0.82768323
111MP0002736_abnormal_nociception_after0.82742981
112MP0002452_abnormal_antigen_presenting0.81386949
113MP0009840_abnormal_foam_cell0.80643271
114MP0002420_abnormal_adaptive_immunity0.79731215
115MP0001819_abnormal_immune_cell0.78891398
116MP0003861_abnormal_nervous_system0.78709628
117MP0010155_abnormal_intestine_physiology0.78564777
118MP0002249_abnormal_larynx_morphology0.78399760
119MP0003890_abnormal_embryonic-extraembry0.77873708
120MP0001986_abnormal_taste_sensitivity0.76558557
121MP0001119_abnormal_female_reproductive0.76235469
122MP0003315_abnormal_perineum_morphology0.76085379
123MP0005395_other_phenotype0.76074447
124MP0001145_abnormal_male_reproductive0.75793991
125MP0003646_muscle_fatigue0.75460741
126MP0002723_abnormal_immune_serum0.75298209
127MP0000778_abnormal_nervous_system0.75114020
128MP0005551_abnormal_eye_electrophysiolog0.74110886
129MP0000858_altered_metastatic_potential0.73341330
130MP0001764_abnormal_homeostasis0.72657390
131MP0003755_abnormal_palate_morphology0.72594971
132MP0005646_abnormal_pituitary_gland0.72461684
133MP0003453_abnormal_keratinocyte_physiol0.72250136
134MP0003880_abnormal_central_pattern0.72198243
135MP0002092_abnormal_eye_morphology0.72053488
136MP0003119_abnormal_digestive_system0.71483946
137MP0003938_abnormal_ear_development0.71198243
138MP0005025_abnormal_response_to0.70801126
139MP0002090_abnormal_vision0.70238438
140MP0002148_abnormal_hypersensitivity_rea0.69513555
141MP0005330_cardiomyopathy0.69083266
142MP0005171_absent_coat_pigmentation0.68987148
143MP0009785_altered_susceptibility_to0.68863531
144MP0002006_tumorigenesis0.68203755
145MP0000477_abnormal_intestine_morphology0.66855577
146MP0001873_stomach_inflammation0.66130973
147MP0001929_abnormal_gametogenesis0.65747059
148MP0000750_abnormal_muscle_regeneration0.64350276
149MP0002111_abnormal_tail_morphology0.62727226
150MP0000653_abnormal_sex_gland0.62182687
151MP0000358_abnormal_cell_content/0.61049405
152MP0002269_muscular_atrophy0.60711497
153MP0005670_abnormal_white_adipose0.60533255

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.75987119
2Breast hypoplasia (HP:0003187)4.63660817
3Reticulocytopenia (HP:0001896)4.41260997
4Abnormality of cells of the erythroid lineage (HP:0012130)4.11595240
5Abnormal number of erythroid precursors (HP:0012131)3.78442807
6Abnormality of the labia minora (HP:0012880)3.69240449
7Carpal bone hypoplasia (HP:0001498)3.37829199
8Acute necrotizing encephalopathy (HP:0006965)3.35654953
9Degeneration of anterior horn cells (HP:0002398)3.27572249
10Abnormality of the anterior horn cell (HP:0006802)3.27572249
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.23373271
12Acute encephalopathy (HP:0006846)3.16761762
13Macrocytic anemia (HP:0001972)3.12621408
14Patellar aplasia (HP:0006443)3.11038577
15Abnormal mitochondria in muscle tissue (HP:0008316)3.09781989
16Rectal fistula (HP:0100590)3.02500602
17Rectovaginal fistula (HP:0000143)3.02500602
18Absent radius (HP:0003974)2.99172267
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90210974
20Abnormality of the duodenum (HP:0002246)2.90152154
21Selective tooth agenesis (HP:0001592)2.89245853
22Aplasia/Hypoplasia of the patella (HP:0006498)2.88933646
23Mitochondrial inheritance (HP:0001427)2.88807539
24Absent thumb (HP:0009777)2.87284870
25Oral leukoplakia (HP:0002745)2.84165744
26Absent forearm bone (HP:0003953)2.83005971
27Aplasia involving forearm bones (HP:0009822)2.83005971
28Impulsivity (HP:0100710)2.78005978
29Progressive macrocephaly (HP:0004481)2.77126821
30Abnormal lung lobation (HP:0002101)2.75956645
31Increased CSF lactate (HP:0002490)2.72740848
32Clubbing of toes (HP:0100760)2.70883525
33Pancreatic fibrosis (HP:0100732)2.65003371
34Abnormality of the carotid arteries (HP:0005344)2.64662137
35Hepatocellular necrosis (HP:0001404)2.63821289
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63363614
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63363614
38Vaginal fistula (HP:0004320)2.62837451
39True hermaphroditism (HP:0010459)2.62154113
40Pustule (HP:0200039)2.61902264
41Multiple enchondromatosis (HP:0005701)2.59787508
42Chromsome breakage (HP:0040012)2.56372565
43Increased hepatocellular lipid droplets (HP:0006565)2.55166697
44Intestinal fistula (HP:0100819)2.53919483
45Rough bone trabeculation (HP:0100670)2.53827140
46Pallor (HP:0000980)2.52769399
47Colon cancer (HP:0003003)2.52054875
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49913651
49Hyperglycinuria (HP:0003108)2.49362180
50Ectopic kidney (HP:0000086)2.49130824
51Abnormality of the ileum (HP:0001549)2.48028901
52Volvulus (HP:0002580)2.46756758
53Pancreatic cysts (HP:0001737)2.45825885
54Cerebral edema (HP:0002181)2.44721932
55Tongue fasciculations (HP:0001308)2.43256657
5611 pairs of ribs (HP:0000878)2.40458014
57Hepatic necrosis (HP:0002605)2.40055462
58Hyperglycinemia (HP:0002154)2.38055919
59Lipid accumulation in hepatocytes (HP:0006561)2.37263983
60Meckel diverticulum (HP:0002245)2.35316843
61Abnormality of the preputium (HP:0100587)2.35184111
62Aplasia/hypoplasia of the humerus (HP:0006507)2.32213089
63Rib fusion (HP:0000902)2.29324926
64Supernumerary spleens (HP:0009799)2.29214653
65Sparse eyelashes (HP:0000653)2.26640264
66Nephroblastoma (Wilms tumor) (HP:0002667)2.26460154
67Muscle fibrillation (HP:0010546)2.25984104
68Duplicated collecting system (HP:0000081)2.23669076
69Microretrognathia (HP:0000308)2.23194832
70Congenital, generalized hypertrichosis (HP:0004540)2.21778687
71Muscle fiber atrophy (HP:0100295)2.17334396
72Abnormality of midbrain morphology (HP:0002418)2.16157836
73Molar tooth sign on MRI (HP:0002419)2.16157836
74IgM deficiency (HP:0002850)2.14398825
75Poikiloderma (HP:0001029)2.13408496
76Hypoplastic pelvis (HP:0008839)2.10923002
77Increased nuchal translucency (HP:0010880)2.10526668
78Neoplasm of the adrenal cortex (HP:0100641)2.10515287
79Sclerocornea (HP:0000647)2.10241923
80Embryonal renal neoplasm (HP:0011794)2.10091595
81Aplastic anemia (HP:0001915)2.09833360
82Myelodysplasia (HP:0002863)2.09222753
83Type 2 muscle fiber atrophy (HP:0003554)2.08112400
84Abnormal number of incisors (HP:0011064)2.07679276
85Renal Fanconi syndrome (HP:0001994)2.07563599
86Premature ovarian failure (HP:0008209)2.07167218
87Premature graying of hair (HP:0002216)2.06344694
88Asplenia (HP:0001746)2.04783437
89Basal cell carcinoma (HP:0002671)2.04631670
90Aplasia/Hypoplasia involving the musculature (HP:0001460)2.03939649
91Abnormality of glycine metabolism (HP:0010895)2.02803725
92Abnormality of serine family amino acid metabolism (HP:0010894)2.02803725
93Abnormality of cochlea (HP:0000375)2.01882339
94Abnormality of glycolysis (HP:0004366)2.01567031
95Increased serum lactate (HP:0002151)2.01563615
96Cortical dysplasia (HP:0002539)1.99874588
97Abnormal hemoglobin (HP:0011902)1.98191851
98Agnosia (HP:0010524)1.97137802
99Anencephaly (HP:0002323)1.96542193
100Hypoplasia of the radius (HP:0002984)1.96474566
101Abnormality of chromosome stability (HP:0003220)1.95895369
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.94202613
103Progressive muscle weakness (HP:0003323)1.94009200
104Glioma (HP:0009733)1.93983885
105Abnormality of the renal collecting system (HP:0004742)1.93903128
106Ependymoma (HP:0002888)1.93763125
107Duplication of thumb phalanx (HP:0009942)1.93310558
108Cerebral hypomyelination (HP:0006808)1.92476756
109Spinal muscular atrophy (HP:0007269)1.91045856
110Missing ribs (HP:0000921)1.90295701
111Trismus (HP:0000211)1.89733348
112Lymphoma (HP:0002665)1.89173743
113Preaxial hand polydactyly (HP:0001177)1.88999629
114Hypoplasia of the pons (HP:0012110)1.88630930
115Bone marrow hypocellularity (HP:0005528)1.87555593
116Oligodactyly (hands) (HP:0001180)1.87150646
117Increased serum pyruvate (HP:0003542)1.87148048
118Sloping forehead (HP:0000340)1.85359761
119Increased IgM level (HP:0003496)1.85128996
120Aplasia/Hypoplasia of the spleen (HP:0010451)1.84341117
121Microvesicular hepatic steatosis (HP:0001414)1.84241802
122Short humerus (HP:0005792)1.84065914
123Cystic liver disease (HP:0006706)1.83714822
124Horseshoe kidney (HP:0000085)1.83154509
125Methylmalonic acidemia (HP:0002912)1.82752388
126Arteriovenous malformation (HP:0100026)1.82699833
127Abnormality of methionine metabolism (HP:0010901)1.82515366
128IgG deficiency (HP:0004315)1.82222706
129Medulloblastoma (HP:0002885)1.81684787
130Short thumb (HP:0009778)1.81551714
131Tracheoesophageal fistula (HP:0002575)1.81501729
132Holoprosencephaly (HP:0001360)1.81092748
133Squamous cell carcinoma (HP:0002860)1.80353400
134Pancytopenia (HP:0001876)1.79874410
135Abnormality of the umbilical cord (HP:0010881)1.79363582
136Abnormality of pyrimidine metabolism (HP:0004353)1.77724434
137Acute lymphatic leukemia (HP:0006721)1.77352075
138Stenosis of the external auditory canal (HP:0000402)1.77304426
139Oligohydramnios (HP:0001562)1.77257929
140Rhabdomyosarcoma (HP:0002859)1.77180582
141Lactic acidosis (HP:0003128)1.76688709
142Abnormality of secondary sexual hair (HP:0009888)1.76215037
143Abnormality of the axillary hair (HP:0100134)1.76215037
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.75699711
145Duodenal stenosis (HP:0100867)1.74804222
146Small intestinal stenosis (HP:0012848)1.74804222
147Aganglionic megacolon (HP:0002251)1.73542495
148Neoplasm of the adrenal gland (HP:0100631)1.73087565
149IgA deficiency (HP:0002720)1.72844241
150Triphalangeal thumb (HP:0001199)1.72840521
151Type I transferrin isoform profile (HP:0003642)1.72829343
152Neoplasm of the colon (HP:0100273)1.72738843
153Abnormality of the pons (HP:0007361)1.71898963
154Abdominal situs inversus (HP:0003363)1.71351194
155Abnormality of abdominal situs (HP:0011620)1.71351194
156Astigmatism (HP:0000483)1.70972073
157Small hand (HP:0200055)1.68643209
158Postaxial foot polydactyly (HP:0001830)1.68320117
159Dandy-Walker malformation (HP:0001305)1.68024143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.49658787
2BUB14.46751668
3WEE13.70264675
4NME23.31025730
5TAF12.86849327
6SRPK12.82945612
7CDC72.48480035
8NEK22.34334426
9EIF2AK12.28875963
10BRSK22.18812253
11NUAK12.09000142
12PLK11.89801393
13MAP4K11.87926586
14CDK71.86101480
15TTK1.75905164
16RPS6KB21.74844755
17TESK21.73897603
18EPHA21.68082809
19STK101.67350780
20AURKB1.67044467
21WNK31.60566796
22NEK11.60356983
23TLK11.59847997
24ACVR1B1.57832754
25VRK11.56077409
26MAP4K21.52286713
27DYRK31.49020617
28BRSK11.48271016
29CHEK21.45027377
30BCKDK1.43369929
31PLK21.42612250
32STK161.41470807
33FLT31.32584169
34KDR1.32226713
35ATR1.31639844
36PIM21.30533789
37BMPR1B1.30151800
38AURKA1.27731090
39PIM11.26767791
40TRIM281.23296840
41AKT31.20787876
42PLK41.19583009
43MAP3K111.19217526
44TSSK61.15685247
45MKNK11.14131545
46EIF2AK31.13619908
47CDK41.13457585
48TIE11.12939928
49MAPKAPK31.11697214
50SMG11.09394561
51STK41.08315982
52ICK1.04288074
53NME11.04254516
54TNIK1.02302313
55MAP3K81.00933925
56MST40.99836777
57TGFBR10.99373707
58MAPK150.97581688
59LRRK20.96700279
60DYRK20.91941412
61CDK60.90990090
62PAK40.90181544
63CCNB10.89637431
64PASK0.87358931
65INSRR0.87297524
66PDK20.86671923
67RPS6KA40.85858976
68PLK30.85808130
69CSNK1G30.85576323
70MAP2K30.85100906
71PNCK0.84827152
72ZAK0.81992842
73CHEK10.80815640
74CDK80.79945872
75ZAP700.78439684
76MAPK110.77951611
77IKBKB0.77156287
78CSNK2A10.76910259
79CSNK1G10.72588905
80MATK0.72094801
81BTK0.71722508
82PINK10.71158583
83PRKCI0.71075236
84CSNK1A1L0.70144366
85FRK0.69288046
86CSNK1G20.67904313
87TYK20.67122948
88MAP3K60.67035074
89MAPKAPK50.65660996
90MAP3K30.65276854
91YES10.64475846
92CSNK2A20.64321295
93BCR0.63718401
94EIF2AK20.62886644
95CDK20.62832847
96JAK30.62651535
97CSK0.61666027
98TXK0.61366736
99ERBB30.61170102
100DYRK1B0.60988522
101KIT0.58720526
102ATM0.56032818
103MAP3K40.55799692
104CDK190.55752561
105STK38L0.55192775
106CDK10.55007394
107EEF2K0.53429911
108MKNK20.53387229
109PAK10.52469808
110STK240.51641580
111BRAF0.50642911
112TRPM70.49713608
113PDK40.49659424
114PDK30.49659424
115BLK0.49494862
116FGFR20.49397397
117LYN0.49260710
118CSF1R0.48769883
119MELK0.47968066
120TGFBR20.47547220
121TEC0.46356328
122GRK60.45538105
123RPS6KA50.44762986
124MINK10.43880609
125EPHA40.43260790
126STK390.42378911
127MAPKAPK20.42365096
128BRD40.42346208
129DAPK10.41458686
130MARK30.41124646
131CHUK0.40625946
132MAP2K70.40490635
133MAP3K100.40084466
134CDK120.39407421
135PBK0.39216780
136STK30.35677928
137PKN10.34613451
138ADRBK20.32357616
139EPHB20.31919672
140PRKDC0.29474122
141CDK90.29161369
142UHMK10.27017195
143CDK11A0.24009608
144MAPK130.23840469
145CSNK1E0.22765967
146MUSK0.21538030
147GRK50.21190129
148CDK180.20305647
149CDK140.19637717

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40282153
2Ribosome_Homo sapiens_hsa030104.09561300
3Mismatch repair_Homo sapiens_hsa034304.04443907
4Base excision repair_Homo sapiens_hsa034103.30255689
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07797135
6RNA polymerase_Homo sapiens_hsa030203.05019717
7Proteasome_Homo sapiens_hsa030503.04596057
8Homologous recombination_Homo sapiens_hsa034402.91167166
9Spliceosome_Homo sapiens_hsa030402.86492071
10Nucleotide excision repair_Homo sapiens_hsa034202.60546447
11RNA transport_Homo sapiens_hsa030132.42233378
12Pyrimidine metabolism_Homo sapiens_hsa002402.21651108
13Protein export_Homo sapiens_hsa030602.20750744
14Cell cycle_Homo sapiens_hsa041102.13727967
15One carbon pool by folate_Homo sapiens_hsa006701.98573734
16Fanconi anemia pathway_Homo sapiens_hsa034601.96510574
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95077959
18Non-homologous end-joining_Homo sapiens_hsa034501.88176010
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78707687
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58624480
21Primary immunodeficiency_Homo sapiens_hsa053401.58064178
22p53 signaling pathway_Homo sapiens_hsa041151.57891918
23Basal transcription factors_Homo sapiens_hsa030221.57604659
24RNA degradation_Homo sapiens_hsa030181.57354246
25Folate biosynthesis_Homo sapiens_hsa007901.35912959
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31662621
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30427120
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30125822
29Alzheimers disease_Homo sapiens_hsa050101.24194562
30mRNA surveillance pathway_Homo sapiens_hsa030151.19826317
31Caffeine metabolism_Homo sapiens_hsa002321.17180213
32Vitamin B6 metabolism_Homo sapiens_hsa007501.15760066
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.15165167
34Biosynthesis of amino acids_Homo sapiens_hsa012301.14068853
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13059269
36Purine metabolism_Homo sapiens_hsa002301.12052573
37Pyruvate metabolism_Homo sapiens_hsa006201.10129663
38Steroid biosynthesis_Homo sapiens_hsa001001.08754939
39Sulfur relay system_Homo sapiens_hsa041221.03292413
40Butanoate metabolism_Homo sapiens_hsa006501.00610776
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.99211054
42Pentose phosphate pathway_Homo sapiens_hsa000300.98067475
43Epstein-Barr virus infection_Homo sapiens_hsa051690.96741161
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94270709
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85715746
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85239839
47Glutathione metabolism_Homo sapiens_hsa004800.84479027
48Herpes simplex infection_Homo sapiens_hsa051680.83531734
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80770448
50Carbon metabolism_Homo sapiens_hsa012000.79171263
51Fructose and mannose metabolism_Homo sapiens_hsa000510.76019702
52Antigen processing and presentation_Homo sapiens_hsa046120.72592395
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.71284729
54Systemic lupus erythematosus_Homo sapiens_hsa053220.71199453
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69843925
56Huntingtons disease_Homo sapiens_hsa050160.67017347
57Arginine and proline metabolism_Homo sapiens_hsa003300.66723908
58Arachidonic acid metabolism_Homo sapiens_hsa005900.65774227
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.63953099
60Selenocompound metabolism_Homo sapiens_hsa004500.63360362
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61550772
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61268760
63Notch signaling pathway_Homo sapiens_hsa043300.59604717
64Cardiac muscle contraction_Homo sapiens_hsa042600.58890288
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56281843
66Viral carcinogenesis_Homo sapiens_hsa052030.53668898
67Phototransduction_Homo sapiens_hsa047440.52786828
68Lysine degradation_Homo sapiens_hsa003100.49535314
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49258073
70Hedgehog signaling pathway_Homo sapiens_hsa043400.48645988
71Parkinsons disease_Homo sapiens_hsa050120.48410509
72HTLV-I infection_Homo sapiens_hsa051660.47663086
73Oocyte meiosis_Homo sapiens_hsa041140.45149340
74Galactose metabolism_Homo sapiens_hsa000520.44863721
75Measles_Homo sapiens_hsa051620.44495616
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43658193
77Metabolic pathways_Homo sapiens_hsa011000.42156430
78Fatty acid degradation_Homo sapiens_hsa000710.41389121
79Alcoholism_Homo sapiens_hsa050340.40489884
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.40386332
81N-Glycan biosynthesis_Homo sapiens_hsa005100.40007937
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38604235
83Propanoate metabolism_Homo sapiens_hsa006400.37593117
84Oxidative phosphorylation_Homo sapiens_hsa001900.36762674
85Small cell lung cancer_Homo sapiens_hsa052220.35042428
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34698184
87Legionellosis_Homo sapiens_hsa051340.33950658
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33709765
89Other glycan degradation_Homo sapiens_hsa005110.31681913
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30523734
91Apoptosis_Homo sapiens_hsa042100.30476537
92Peroxisome_Homo sapiens_hsa041460.30234745
93Linoleic acid metabolism_Homo sapiens_hsa005910.30227847
94Shigellosis_Homo sapiens_hsa051310.28523547
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27491184
96Hippo signaling pathway_Homo sapiens_hsa043900.27341447
97Regulation of autophagy_Homo sapiens_hsa041400.26575401
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26341382
99Hematopoietic cell lineage_Homo sapiens_hsa046400.25390645
100Basal cell carcinoma_Homo sapiens_hsa052170.25142113
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25095321
102MicroRNAs in cancer_Homo sapiens_hsa052060.24582234
103Fatty acid biosynthesis_Homo sapiens_hsa000610.24298240
104Thyroid cancer_Homo sapiens_hsa052160.23978554
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23960206
106Allograft rejection_Homo sapiens_hsa053300.23771277
107Fatty acid metabolism_Homo sapiens_hsa012120.23714970
108Viral myocarditis_Homo sapiens_hsa054160.22978459
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22970816
110Vitamin digestion and absorption_Homo sapiens_hsa049770.22711785
111Tryptophan metabolism_Homo sapiens_hsa003800.21612758
112Olfactory transduction_Homo sapiens_hsa047400.21053397
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20998460
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19985954
115Retinol metabolism_Homo sapiens_hsa008300.19658195
116Wnt signaling pathway_Homo sapiens_hsa043100.19109564
117beta-Alanine metabolism_Homo sapiens_hsa004100.18706493
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.17484350
119Nitrogen metabolism_Homo sapiens_hsa009100.17026525
120B cell receptor signaling pathway_Homo sapiens_hsa046620.16988522
121Fatty acid elongation_Homo sapiens_hsa000620.16604137
122Chemical carcinogenesis_Homo sapiens_hsa052040.16285415
123TGF-beta signaling pathway_Homo sapiens_hsa043500.16089771
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.12655487
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05261559
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05163523
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03684046
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01080558
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.00025511

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