RDH8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration pathway. This enzymatic reaction is the rate-limiting step in the visual cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* phototransduction, visible light (GO:0007603)9.97169822
2* detection of visible light (GO:0009584)9.71463705
3* detection of light stimulus (GO:0009583)9.69245502
4GMP metabolic process (GO:0046037)9.58825798
5* visual perception (GO:0007601)8.63716486
6* sensory perception of light stimulus (GO:0050953)8.53564306
7positive regulation of guanylate cyclase activity (GO:0031284)8.43770721
8regulation of guanylate cyclase activity (GO:0031282)7.61368229
9sperm motility (GO:0030317)7.23447155
10cellular response to light stimulus (GO:0071482)7.20409946
11acrosome reaction (GO:0007340)7.10676697
12photoreceptor cell differentiation (GO:0046530)6.80680320
13eye photoreceptor cell differentiation (GO:0001754)6.80680320
14* detection of external stimulus (GO:0009581)6.78186201
15* detection of abiotic stimulus (GO:0009582)6.64524611
16retina development in camera-type eye (GO:0060041)6.48389674
17fusion of sperm to egg plasma membrane (GO:0007342)6.14503158
18regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.75869429
19regulation of cGMP metabolic process (GO:0030823)5.64071766
20multicellular organism reproduction (GO:0032504)5.41023346
21cellular ketone body metabolic process (GO:0046950)5.27965738
22plasma membrane fusion (GO:0045026)5.15963607
23positive regulation of cGMP biosynthetic process (GO:0030828)5.15672271
24establishment of protein localization to Golgi (GO:0072600)5.08386948
25reproduction (GO:0000003)5.01049165
26protein targeting to Golgi (GO:0000042)5.00051290
27spermatid development (GO:0007286)4.97402390
28regulation of cGMP biosynthetic process (GO:0030826)4.83542884
29retrograde transport, vesicle recycling within Golgi (GO:0000301)4.76625264
30detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.76500634
31sperm-egg recognition (GO:0035036)4.74050903
32protein polyglutamylation (GO:0018095)4.72875548
33sperm capacitation (GO:0048240)4.70125506
34ketone body metabolic process (GO:1902224)4.69288353
35single strand break repair (GO:0000012)4.68911272
36nonmotile primary cilium assembly (GO:0035058)4.65726594
37regulation of cilium movement (GO:0003352)4.62287470
38cellular response to radiation (GO:0071478)4.62244036
39positive regulation of cGMP metabolic process (GO:0030825)4.53500801
40sexual reproduction (GO:0019953)4.52457972
41regulation of clathrin-mediated endocytosis (GO:2000369)4.50534919
42phosphatidylethanolamine metabolic process (GO:0046337)4.47675216
43adaptation of signaling pathway (GO:0023058)4.47235743
44phosphatidylethanolamine biosynthetic process (GO:0006646)4.29428223
45microtubule polymerization or depolymerization (GO:0031109)4.27287484
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.24646546
47microtubule depolymerization (GO:0007019)4.18969340
48protein localization to Golgi apparatus (GO:0034067)4.15921488
49cell wall macromolecule metabolic process (GO:0044036)4.15658538
50cell wall macromolecule catabolic process (GO:0016998)4.09940485
51axonemal dynein complex assembly (GO:0070286)4.09634064
52retina layer formation (GO:0010842)4.09501615
53regulation of short-term neuronal synaptic plasticity (GO:0048172)4.07766567
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.05954695
55regulation of memory T cell differentiation (GO:0043380)4.05612731
56* sensory perception (GO:0007600)4.04940791
57regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.04235472
58negative regulation of multicellular organism growth (GO:0040015)4.01544130
59calcium ion-dependent exocytosis (GO:0017156)4.00397426
60piRNA metabolic process (GO:0034587)3.96808427
61regulation of voltage-gated calcium channel activity (GO:1901385)3.91235976
62cell-cell recognition (GO:0009988)3.89368584
63spermatogenesis (GO:0007283)3.88597995
64receptor guanylyl cyclase signaling pathway (GO:0007168)3.87873783
65male gamete generation (GO:0048232)3.87588625
66epithelial cilium movement (GO:0003351)3.85629860
67peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.85581343
68binding of sperm to zona pellucida (GO:0007339)3.81730097
69* response to light stimulus (GO:0009416)3.76380178
70cellular potassium ion homeostasis (GO:0030007)3.68781858
71cell morphogenesis involved in neuron differentiation (GO:0048667)3.66041589
72rRNA methylation (GO:0031167)3.65665881
73chromosome condensation (GO:0030261)3.58868351
74spermatid nucleus differentiation (GO:0007289)3.58353168
75gamete generation (GO:0007276)3.56784264
76protein localization to synapse (GO:0035418)3.56380334
77DNA packaging (GO:0006323)3.54652289
78neuron development (GO:0048666)3.53612255
79single fertilization (GO:0007338)3.48728850
80response to pheromone (GO:0019236)3.43788365
81prenylation (GO:0097354)3.41723828
82protein prenylation (GO:0018342)3.41723828
83synaptic vesicle docking involved in exocytosis (GO:0016081)3.35850872
84indole-containing compound catabolic process (GO:0042436)3.34984291
85indolalkylamine catabolic process (GO:0046218)3.34984291
86tryptophan catabolic process (GO:0006569)3.34984291
87membrane hyperpolarization (GO:0060081)3.31458123
88positive regulation of mitochondrial fission (GO:0090141)3.30750696
89lipid translocation (GO:0034204)3.28657424
90phospholipid translocation (GO:0045332)3.28657424
91centriole replication (GO:0007099)3.26859718
92synaptic vesicle maturation (GO:0016188)3.25444273
93cilium or flagellum-dependent cell motility (GO:0001539)3.25314562
94CDP-diacylglycerol biosynthetic process (GO:0016024)3.24851684
95indolalkylamine metabolic process (GO:0006586)3.22765813
96cilium movement (GO:0003341)3.14326404
97DNA methylation involved in gamete generation (GO:0043046)3.14292245
98positive regulation of sodium ion transmembrane transport (GO:1902307)3.13842164
99sodium ion export (GO:0071436)3.12506036
100positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11131090
101coenzyme catabolic process (GO:0009109)3.09575801
102behavioral response to ethanol (GO:0048149)3.08609462
103positive regulation of neurotransmitter transport (GO:0051590)3.06743314
104negative regulation of receptor-mediated endocytosis (GO:0048261)3.06479457
105positive regulation of Rab GTPase activity (GO:0032851)3.06153837
106regulation of Rab GTPase activity (GO:0032313)3.06153837
107positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.04903332
108microtubule severing (GO:0051013)3.04139289
109retina homeostasis (GO:0001895)3.04036991
110male meiosis I (GO:0007141)3.01422462
111protein K11-linked deubiquitination (GO:0035871)3.01402384
112CDP-diacylglycerol metabolic process (GO:0046341)2.99443319
113regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.99330932
114regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.99330932
115alanine transport (GO:0032328)2.96891828
116fertilization (GO:0009566)2.95821917
117potassium ion homeostasis (GO:0055075)2.93913885
118rRNA modification (GO:0000154)2.92990901
119NAD biosynthetic process (GO:0009435)2.92329027
120regulation of interleukin-13 production (GO:0032656)2.91180139
121short-term memory (GO:0007614)2.90633687
122chemosensory behavior (GO:0007635)2.88684032
123seminiferous tubule development (GO:0072520)2.88552222
124tryptophan metabolic process (GO:0006568)2.86886029
125sex differentiation (GO:0007548)2.84130139
126regulation of establishment of cell polarity (GO:2000114)2.83238489
127positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.82604674
128response to histamine (GO:0034776)2.82080960
129regulation of transcription involved in cell fate commitment (GO:0060850)2.81465765
130regulation of action potential (GO:0098900)2.81442838
131germ cell development (GO:0007281)2.80174119
132mitochondrion transport along microtubule (GO:0047497)2.77673787
133establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77673787
134axoneme assembly (GO:0035082)2.75907096
135detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.75720249
136regulation of microtubule-based movement (GO:0060632)2.75601513
137epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73995653
138* retinoid metabolic process (GO:0001523)2.73303070
139multicellular organismal reproductive process (GO:0048609)2.72891367
140male meiosis (GO:0007140)2.71465252
141negative regulation of inclusion body assembly (GO:0090084)2.70152937
142positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.69947837
143detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.69487461
144regulation of MHC class I biosynthetic process (GO:0045343)2.69225478
145positive regulation of meiosis (GO:0045836)2.68596555
146cell differentiation involved in metanephros development (GO:0072202)2.68159223
147regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.67316395
148regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.66956861
149centrosome duplication (GO:0051298)2.65344887
150RNA destabilization (GO:0050779)2.65307520
151indole-containing compound metabolic process (GO:0042430)2.65250116
152kynurenine metabolic process (GO:0070189)2.65091795
153cellular biogenic amine catabolic process (GO:0042402)2.64987152
154amine catabolic process (GO:0009310)2.64987152
155antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60768647
156regulation of interleukin-5 production (GO:0032674)2.60731486
157cellular process involved in reproduction in multicellular organism (GO:0022412)2.59123760
158regulation of penile erection (GO:0060405)2.58659511
159spinal cord motor neuron differentiation (GO:0021522)2.57856203
160detection of chemical stimulus involved in sensory perception (GO:0050907)2.56253827
161negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56185999
162regulation of synaptic vesicle exocytosis (GO:2000300)2.55765804
163* response to radiation (GO:0009314)2.54487804
164post-embryonic morphogenesis (GO:0009886)2.54305330
165gamma-aminobutyric acid transport (GO:0015812)2.53315608
166* diterpenoid metabolic process (GO:0016101)2.52853953
167metanephric tubule development (GO:0072170)2.52463163
168metanephric nephron tubule development (GO:0072234)2.52463163
169negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51736300
170centriole assembly (GO:0098534)2.51363561
171platelet dense granule organization (GO:0060155)2.50566576
172positive regulation of ERBB signaling pathway (GO:1901186)2.50174661
173righting reflex (GO:0060013)2.49666345
174lipoprotein transport (GO:0042953)2.48087552
175establishment of mitochondrion localization (GO:0051654)2.44193947
176potassium ion import (GO:0010107)2.40978138
177dopamine receptor signaling pathway (GO:0007212)2.39680593
178lactate metabolic process (GO:0006089)2.38900806
179negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.38008362
180negative regulation of cation channel activity (GO:2001258)2.36352605
181synaptic vesicle exocytosis (GO:0016079)2.34765072
182cellular response to abiotic stimulus (GO:0071214)2.33526149
183positive regulation of vesicle fusion (GO:0031340)2.32397176
184negative regulation of calcium ion transmembrane transport (GO:1903170)2.31788140
185regulation of rhodopsin mediated signaling pathway (GO:0022400)17.0248823
186rhodopsin mediated signaling pathway (GO:0016056)16.7042962
187retinal cone cell development (GO:0046549)14.6767263
188photoreceptor cell maintenance (GO:0045494)12.1331951
189detection of light stimulus involved in visual perception (GO:0050908)11.9619678
190detection of light stimulus involved in sensory perception (GO:0050962)11.9619678
191photoreceptor cell development (GO:0042461)11.8719720
192eye photoreceptor cell development (GO:0042462)11.2899677
193retinal rod cell development (GO:0046548)10.9784828
194protein-chromophore linkage (GO:0018298)10.2665924
195* phototransduction (GO:0007602)10.0972419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.95840323
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73408246
3GBX2_23144817_ChIP-Seq_PC3_Human3.18689755
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.00827180
5ZNF274_21170338_ChIP-Seq_K562_Hela2.99556583
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.59535203
7DROSHA_22980978_ChIP-Seq_HELA_Human2.59165662
8TAF15_26573619_Chip-Seq_HEK293_Human2.53195868
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49519338
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43948574
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30747343
12VDR_22108803_ChIP-Seq_LS180_Human2.22386428
13ER_23166858_ChIP-Seq_MCF-7_Human2.20350610
14EZH2_22144423_ChIP-Seq_EOC_Human2.14368834
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06767038
16AR_21572438_ChIP-Seq_LNCaP_Human2.04665628
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.00817756
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.00777393
19CBP_20019798_ChIP-Seq_JUKART_Human2.00653897
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.00653897
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00278895
22FUS_26573619_Chip-Seq_HEK293_Human1.94783717
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93578710
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.89947208
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86710240
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86710240
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86529258
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84757194
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.82478819
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80050139
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.79861308
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74144606
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.73728168
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.73299470
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71587264
36P53_22127205_ChIP-Seq_FIBROBLAST_Human1.70058877
37KDM2B_26808549_Chip-Seq_K562_Human1.67659815
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64537604
39AR_25329375_ChIP-Seq_VCAP_Human1.64479055
40* REST_21632747_ChIP-Seq_MESCs_Mouse1.64127929
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.61558315
42AR_19668381_ChIP-Seq_PC3_Human1.60312367
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59784940
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57994845
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53009710
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53009710
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51666951
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49988505
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49710336
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.49077947
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48381227
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48321360
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.46505547
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.45070198
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.44518299
56TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.44514513
57ERA_21632823_ChIP-Seq_H3396_Human1.43241967
58SMAD4_21799915_ChIP-Seq_A2780_Human1.42407311
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41552690
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.39906321
61* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39682988
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.39385097
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38505691
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.37707630
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.37429732
66NCOR_22424771_ChIP-Seq_293T_Human1.37159558
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36292811
68RUNX2_22187159_ChIP-Seq_PCA_Human1.36072763
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35469944
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34425741
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34114158
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.32826654
73TBL1_22424771_ChIP-Seq_293T_Human1.30894533
74NANOG_20526341_ChIP-Seq_ESCs_Human1.29890940
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29801747
76CTCF_27219007_Chip-Seq_Bcells_Human1.28491984
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.28080186
78NANOG_19829295_ChIP-Seq_ESCs_Human1.28011215
79SOX2_19829295_ChIP-Seq_ESCs_Human1.28011215
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27306654
81MYC_19829295_ChIP-Seq_ESCs_Human1.27080293
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27015489
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26850218
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.26770600
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25500185
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.25499261
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25281821
88BCAT_22108803_ChIP-Seq_LS180_Human1.24762893
89OCT4_20526341_ChIP-Seq_ESCs_Human1.22909315
90SMC4_20622854_ChIP-Seq_HELA_Human1.22899612
91TCF4_22108803_ChIP-Seq_LS180_Human1.22764427
92STAT3_23295773_ChIP-Seq_U87_Human1.22616958
93IGF1R_20145208_ChIP-Seq_DFB_Human1.21998225
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20881096
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.20881096
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20463242
97AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20230759
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20114230
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.19839043
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19155170
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19081300
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17817473
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.17418434
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17286151
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16720716
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16678634
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16576429
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.15653929
109TP53_18474530_ChIP-ChIP_U2OS_Human1.14145096
110SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13846295
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13683582
112WDR5_24793694_ChIP-Seq_LNCAP_Human1.13614823
113CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13543436
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.12853897
115ETV1_20927104_ChIP-Seq_GIST48_Human1.12059285
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11988938
117CREB1_26743006_Chip-Seq_LNCaP_Human1.11774906
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10919500
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08576179
120EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08448215
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08440058
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.08388460
123FOXH1_21741376_ChIP-Seq_EPCs_Human1.07705673
124CBP_21632823_ChIP-Seq_H3396_Human1.07207765
125NFYB_21822215_ChIP-Seq_K562_Human1.06972447
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06553990
127RAC3_21632823_ChIP-Seq_H3396_Human1.06361979
128TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06273025
129SMRT_27268052_Chip-Seq_Bcells_Human1.06061568
130KDM2B_26808549_Chip-Seq_REH_Human1.05036045
131HOXB7_26014856_ChIP-Seq_BT474_Human1.04860589
132YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04254635
133CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04230875
134P300_19829295_ChIP-Seq_ESCs_Human1.03815337
135RBPJ_21746931_ChIP-Seq_IB4_Human1.03531000
136EGR1_19032775_ChIP-ChIP_M12_Human1.02601012
137PHF8_20622853_ChIP-Seq_HELA_Human1.02457632
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02387691
139HNFA_21074721_ChIP-Seq_CACO-2_Human1.02025619
140PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01321950
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.01026809
142WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00545269
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00295878
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99748623
145NFYA_21822215_ChIP-Seq_K562_Human0.99610769
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.99580645
147RING1B_27294783_Chip-Seq_ESCs_Mouse0.99200578
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99187817
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98439999
150NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97428354
151OCT1_27270436_Chip-Seq_PROSTATE_Human0.97197488
152TCF4_23295773_ChIP-Seq_U87_Human0.96417999
153VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96183007
154MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94506963
155RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94261716
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93995798
157DPY_21335234_ChIP-Seq_ESCs_Mouse0.93416924
158NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93051999
159TAF2_19829295_ChIP-Seq_ESCs_Human0.92441160
160ERG_21242973_ChIP-ChIP_JURKAT_Human0.91945837
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91857013
162CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91301873
163PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89828930
164EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89682807
165EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89440623
166AHR_22903824_ChIP-Seq_MCF-7_Human0.89397401
167CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89326432
168P68_20966046_ChIP-Seq_HELA_Human0.89045674
169SMAD4_21741376_ChIP-Seq_ESCs_Human0.88423920
170CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88194495
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.86608141
172ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85858969
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.85319533
174OCT4_19829295_ChIP-Seq_ESCs_Human0.84787269
175LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84265364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003011_delayed_dark_adaptation8.37036957
2MP0006072_abnormal_retinal_apoptosis7.25868510
3* MP0005253_abnormal_eye_physiology6.97645626
4MP0005410_abnormal_fertilization6.01821654
5MP0003950_abnormal_plasma_membrane4.32158777
6MP0005195_abnormal_posterior_eye4.17809479
7MP0003195_calcinosis3.84290013
8MP0001324_abnormal_eye_pigmentation3.71056137
9MP0002090_abnormal_vision3.54968034
10* MP0005391_vision/eye_phenotype3.38075196
11MP0002229_neurodegeneration2.86457296
12MP0005423_abnormal_somatic_nervous2.68274859
13MP0002638_abnormal_pupillary_reflex2.60136940
14MP0003698_abnormal_male_reproductive2.50494939
15MP0001929_abnormal_gametogenesis2.15029531
16MP0005645_abnormal_hypothalamus_physiol2.10896710
17MP0002752_abnormal_somatic_nervous2.10062917
18MP0002736_abnormal_nociception_after2.09094408
19MP0005551_abnormal_eye_electrophysiolog10.3451754
20MP0002653_abnormal_ependyma_morphology1.99422858
21MP0001764_abnormal_homeostasis1.85808033
22MP0005646_abnormal_pituitary_gland1.84143940
23MP0001501_abnormal_sleep_pattern1.75152718
24MP0000372_irregular_coat_pigmentation1.71465738
25MP0005670_abnormal_white_adipose1.66233923
26MP0001986_abnormal_taste_sensitivity1.62407889
27MP0002822_catalepsy1.60611911
28MP0005671_abnormal_response_to1.58465964
29MP0003878_abnormal_ear_physiology1.54266346
30MP0005377_hearing/vestibular/ear_phenot1.54266346
31MP0002882_abnormal_neuron_morphology1.51778415
32MP0002282_abnormal_trachea_morphology1.51169988
33MP0004019_abnormal_vitamin_homeostasis1.50216583
34MP0005379_endocrine/exocrine_gland_phen1.48405485
35MP0001502_abnormal_circadian_rhythm1.46572151
36MP0002735_abnormal_chemical_nociception1.41445128
37MP0003718_maternal_effect1.40666213
38MP0004233_abnormal_muscle_weight1.40120989
39MP0002234_abnormal_pharynx_morphology1.39360043
40MP0002876_abnormal_thyroid_physiology1.35297593
41MP0005171_absent_coat_pigmentation1.33298985
42MP0006276_abnormal_autonomic_nervous1.33001800
43MP0002138_abnormal_hepatobiliary_system1.32692432
44MP0002161_abnormal_fertility/fecundity1.31931406
45MP0005167_abnormal_blood-brain_barrier1.30806773
46MP0000013_abnormal_adipose_tissue1.27570235
47MP0005075_abnormal_melanosome_morpholog1.26631506
48MP0002837_dystrophic_cardiac_calcinosis1.25919912
49MP0002210_abnormal_sex_determination1.21392811
50MP0001984_abnormal_olfaction1.20028878
51MP0008877_abnormal_DNA_methylation1.19383153
52MP0005310_abnormal_salivary_gland1.16064301
53MP0004885_abnormal_endolymph1.15717196
54MP0003136_yellow_coat_color1.14591490
55MP0001348_abnormal_lacrimal_gland1.14047384
56MP0003787_abnormal_imprinting1.13756149
57MP0001765_abnormal_ion_homeostasis1.12305599
58MP0001145_abnormal_male_reproductive1.11494936
59MP0000653_abnormal_sex_gland1.10400836
60MP0000427_abnormal_hair_cycle1.08589404
61MP0005647_abnormal_sex_gland1.05870164
62MP0000371_diluted_coat_color1.04899138
63MP0002733_abnormal_thermal_nociception1.04212040
64MP0004270_analgesia1.03894600
65MP0000569_abnormal_digit_pigmentation1.02947468
66MP0001486_abnormal_startle_reflex1.01320872
67MP0001970_abnormal_pain_threshold1.00659820
68MP0001756_abnormal_urination1.00501668
69MP0005636_abnormal_mineral_homeostasis1.00316238
70MP0005394_taste/olfaction_phenotype0.99550019
71MP0005499_abnormal_olfactory_system0.99550019
72MP0005365_abnormal_bile_salt0.97997750
73MP0002557_abnormal_social/conspecific_i0.97558766
74MP0006292_abnormal_olfactory_placode0.97097654
75MP0002095_abnormal_skin_pigmentation0.94704982
76MP0005395_other_phenotype0.94269799
77MP0005197_abnormal_uvea_morphology0.93957937
78MP0005332_abnormal_amino_acid0.92517188
79MP0005085_abnormal_gallbladder_physiolo0.92364123
80MP0002332_abnormal_exercise_endurance0.90535997
81MP0005367_renal/urinary_system_phenotyp0.90105350
82MP0000516_abnormal_urinary_system0.90105350
83MP0003880_abnormal_central_pattern0.87376525
84MP0003634_abnormal_glial_cell0.85567351
85MP0008995_early_reproductive_senescence0.84575520
86MP0001905_abnormal_dopamine_level0.82831205
87MP0009053_abnormal_anal_canal0.82703595
88MP0009643_abnormal_urine_homeostasis0.82428757
89MP0000230_abnormal_systemic_arterial0.82396413
90MP0000015_abnormal_ear_pigmentation0.82080427
91MP0008789_abnormal_olfactory_epithelium0.80786351
92MP0002272_abnormal_nervous_system0.79757884
93MP0000538_abnormal_urinary_bladder0.77860577
94MP0001485_abnormal_pinna_reflex0.77199404
95MP0002127_abnormal_cardiovascular_syste0.75682542
96MP0002168_other_aberrant_phenotype0.74510817
97MP0005535_abnormal_body_temperature0.73310999
98MP0003172_abnormal_lysosome_physiology0.72523184
99MP0005389_reproductive_system_phenotype0.69582478
100MP0002064_seizures0.68973162
101MP0010386_abnormal_urinary_bladder0.68576168
102MP0003635_abnormal_synaptic_transmissio0.67870899
103MP0002734_abnormal_mechanical_nocicepti0.65522305
104MP0005248_abnormal_Harderian_gland0.63455519
105MP0004859_abnormal_synaptic_plasticity0.63449291
106MP0005187_abnormal_penis_morphology0.62328956
107MP0001286_abnormal_eye_development0.62274426
108MP0009046_muscle_twitch0.60353834
109MP0000465_gastrointestinal_hemorrhage0.59980909
110MP0001963_abnormal_hearing_physiology0.58071614
111MP0002067_abnormal_sensory_capabilities0.52508908
112MP0002063_abnormal_learning/memory/cond0.52032818
113MP0004215_abnormal_myocardial_fiber0.50394027
114MP0008004_abnormal_stomach_pH0.48097070
115MP0003045_fibrosis0.45232409
116MP0004782_abnormal_surfactant_physiolog0.43161168
117MP0001968_abnormal_touch/_nociception0.42925181
118MP0004924_abnormal_behavior0.42239985
119MP0005386_behavior/neurological_phenoty0.42239985
120MP0009745_abnormal_behavioral_response0.41712779
121MP0004742_abnormal_vestibular_system0.41505500
122MP0002572_abnormal_emotion/affect_behav0.41457645
123MP0002697_abnormal_eye_size0.40132373
124MP0004145_abnormal_muscle_electrophysio0.39967541
125MP0000631_abnormal_neuroendocrine_gland0.39440432
126MP0003890_abnormal_embryonic-extraembry0.38904441
127MP0005376_homeostasis/metabolism_phenot0.38726290
128MP0002102_abnormal_ear_morphology0.37492405
129MP0008569_lethality_at_weaning0.34980827
130MP0005620_abnormal_muscle_contractility0.34412737
131MP0004043_abnormal_pH_regulation0.32655218
132MP0002184_abnormal_innervation0.31372923
133MP0002152_abnormal_brain_morphology0.30576203
134MP0004085_abnormal_heartbeat0.29953190
135MP0000026_abnormal_inner_ear0.29743480
136MP0010030_abnormal_orbit_morphology0.29737751
137MP0000751_myopathy0.28081482
138MP0002066_abnormal_motor_capabilities/c0.27469387
139MP0002108_abnormal_muscle_morphology0.26215701
140MP0005193_abnormal_anterior_eye0.24536011
141MP0004142_abnormal_muscle_tone0.24387735
142MP0001915_intracranial_hemorrhage0.24297316
143MP0004811_abnormal_neuron_physiology0.22850027
144MP0004036_abnormal_muscle_relaxation0.22334497
145MP0010368_abnormal_lymphatic_system0.21843411
146MP0000778_abnormal_nervous_system0.21609381
147MP0003633_abnormal_nervous_system0.21596956
148MP0005595_abnormal_vascular_smooth0.21229988
149MP0009780_abnormal_chondrocyte_physiolo0.21068794
150MP0005076_abnormal_cell_differentiation0.20039721
151MP0005330_cardiomyopathy0.20023485
152MP0003646_muscle_fatigue0.19460249
153MP0008961_abnormal_basal_metabolism0.19101377
154MP0002928_abnormal_bile_duct0.18251910
155MP0003137_abnormal_impulse_conducting0.17637368
156MP0002909_abnormal_adrenal_gland0.17248854
157MP0001346_abnormal_lacrimal_gland0.16905909
158MP0001177_atelectasis0.16689458
159MP0003632_abnormal_nervous_system0.15887777
160MP0003252_abnormal_bile_duct0.14867162
161MP0000955_abnormal_spinal_cord0.14779858
162MP0003631_nervous_system_phenotype0.14770976
163MP0000749_muscle_degeneration0.14584269
164MP0001661_extended_life_span0.14212137
165MP0001293_anophthalmia0.13904268

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)9.90069317
2Dyschromatopsia (HP:0007641)9.28885425
3Central scotoma (HP:0000603)9.21189229
4Pigmentary retinal degeneration (HP:0001146)8.75478828
5Abnormality of macular pigmentation (HP:0008002)8.43512832
6Scotoma (HP:0000575)8.02575992
7Chorioretinal atrophy (HP:0000533)7.95274006
8Pendular nystagmus (HP:0012043)7.51114929
9Attenuation of retinal blood vessels (HP:0007843)7.34848634
10Abolished electroretinogram (ERG) (HP:0000550)6.98620352
11Decreased central vision (HP:0007663)6.61262502
12Photophobia (HP:0000613)5.60884810
13Posterior subcapsular cataract (HP:0007787)5.57475235
14Type II diabetes mellitus (HP:0005978)5.53167887
15Severe visual impairment (HP:0001141)5.27504718
16Macular degeneration (HP:0000608)5.24850044
17Vitreoretinal degeneration (HP:0000655)5.07548179
18Cone-rod dystrophy (HP:0000548)4.93189521
19Keratoconus (HP:0000563)4.90599006
20Increased corneal curvature (HP:0100692)4.90599006
21Constricted visual fields (HP:0001133)4.65679933
22Choroideremia (HP:0001139)4.45549243
23Retinitis pigmentosa (HP:0000510)4.19593931
24Metabolic alkalosis (HP:0200114)3.88044638
25Hypokalemic alkalosis (HP:0001949)3.85696786
26Gaze-evoked nystagmus (HP:0000640)3.77334307
27Dynein arm defect of respiratory motile cilia (HP:0012255)3.76373185
28Absent/shortened dynein arms (HP:0200106)3.76373185
29Decreased electroretinogram (ERG) amplitude (HP:0000654)3.65848954
30Chronic hepatic failure (HP:0100626)3.63232608
31Action tremor (HP:0002345)3.50544591
32Increased circulating renin level (HP:0000848)3.50458934
33Subcapsular cataract (HP:0000523)3.49717170
34Progressive visual loss (HP:0000529)3.32598731
35Polyuria (HP:0000103)3.30642767
36Congenital sensorineural hearing impairment (HP:0008527)3.28728174
37Tubulointerstitial nephritis (HP:0001970)3.07616961
38Abnormal urine output (HP:0012590)3.07348673
39Abnormal drinking behavior (HP:0030082)3.01688997
40Polydipsia (HP:0001959)3.01688997
41Type II lissencephaly (HP:0007260)2.97175269
42Prostate neoplasm (HP:0100787)2.96191644
43Hypomagnesemia (HP:0002917)2.95095662
44Retinal dysplasia (HP:0007973)2.94887821
45Tetany (HP:0001281)2.89146930
46Retinal atrophy (HP:0001105)2.87455535
47Abnormal ciliary motility (HP:0012262)2.70241397
48Abnormal respiratory motile cilium morphology (HP:0005938)2.65614772
49Abnormal respiratory epithelium morphology (HP:0012253)2.65614772
50Abnormal respiratory motile cilium physiology (HP:0012261)2.64282251
51Atonic seizures (HP:0010819)2.61710186
52Dysmetric saccades (HP:0000641)2.59023807
53Abnormality of renal excretion (HP:0011036)2.58212059
54Absence seizures (HP:0002121)2.57561795
55Dialeptic seizures (HP:0011146)2.45750357
56Wide nasal bridge (HP:0000431)2.45502817
57Nephronophthisis (HP:0000090)2.45253005
58Abnormality of the hepatic vasculature (HP:0006707)2.44550503
59Optic disc pallor (HP:0000543)2.41576645
60Abnormality of the renal medulla (HP:0100957)2.40300802
61Hyperaldosteronism (HP:0000859)2.35252592
62Abnormal biliary tract physiology (HP:0012439)2.33972455
63Bile duct proliferation (HP:0001408)2.33972455
64Azoospermia (HP:0000027)2.26004803
65Abnormality of chloride homeostasis (HP:0011422)2.22977879
66Infertility (HP:0000789)2.19429670
67Generalized aminoaciduria (HP:0002909)2.19115870
68Limb ataxia (HP:0002070)2.18923635
69Abnormality of the aortic arch (HP:0012303)2.16851026
70Abnormality of magnesium homeostasis (HP:0004921)2.14835865
71Hypokalemia (HP:0002900)2.12907009
72Gait imbalance (HP:0002141)2.11279177
73Focal seizures (HP:0007359)2.10640590
74Esotropia (HP:0000565)2.10395870
75Focal motor seizures (HP:0011153)2.08887423
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08455790
77Congenital primary aphakia (HP:0007707)2.08208501
78Renal salt wasting (HP:0000127)2.07147103
79Hyperventilation (HP:0002883)2.03924145
80Hyperactive renin-angiotensin system (HP:0000841)2.00118076
81Congenital stationary night blindness (HP:0007642)13.6234078
82Bony spicule pigmentary retinopathy (HP:0007737)11.5676169
83Absent rod-and cone-mediated responses on ERG (HP:0007688)10.5862800
84Abnormality of potassium homeostasis (HP:0011042)1.96145737
85Polar cataract (HP:0010696)1.94402739
86Type 2 muscle fiber atrophy (HP:0003554)1.90184838
87Absent speech (HP:0001344)1.89825335
88Spastic paraparesis (HP:0002313)1.89483991
89Tubular atrophy (HP:0000092)1.88247308
90Alkalosis (HP:0001948)1.85648351
91Tubulointerstitial abnormality (HP:0001969)1.84991509
92Facial shape deformation (HP:0011334)1.83666424
93Potter facies (HP:0002009)1.83666424
94Urinary bladder sphincter dysfunction (HP:0002839)1.83359540
95Abnormal spermatogenesis (HP:0008669)1.83261069
96Nephrogenic diabetes insipidus (HP:0009806)1.82530900
97Abnormality of the renal cortex (HP:0011035)1.82391810
98Hypothermia (HP:0002045)1.82275819
99Medial flaring of the eyebrow (HP:0010747)1.77602681
100Horizontal nystagmus (HP:0000666)1.70919228
101Impaired vibratory sensation (HP:0002495)1.70010649
102Portal hypertension (HP:0001409)1.67463996
103Muscle fiber atrophy (HP:0100295)1.66339153
104Abnormality of renin-angiotensin system (HP:0000847)1.65720614
105Interstitial pulmonary disease (HP:0006530)1.58545173
106Optic atrophy (HP:0000648)1.58288291
107Poor coordination (HP:0002370)1.58092448
108Severe Myopia (HP:0011003)1.47283364
109Vaginal atresia (HP:0000148)1.40920376
110Genital tract atresia (HP:0001827)1.36088497
111Pancreatic fibrosis (HP:0100732)1.33703218
112Dysdiadochokinesis (HP:0002075)1.33324257
113Epileptic encephalopathy (HP:0200134)1.28963339
114True hermaphroditism (HP:0010459)1.26465827
115Aplasia/Hypoplasia of the lens (HP:0008063)1.21297621
116Abnormality of the fovea (HP:0000493)1.17529621
117Hypoplasia of the fovea (HP:0007750)1.14064879
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.14064879
119Retinal detachment (HP:0000541)1.13779356
120Truncal ataxia (HP:0002078)1.11376766
121Astigmatism (HP:0000483)1.10455324
122Febrile seizures (HP:0002373)1.08476084
123Cystic liver disease (HP:0006706)1.08347767
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.02213544
125Pancreatic cysts (HP:0001737)1.02182652
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.00655574
127Visual hallucinations (HP:0002367)0.97389731
128Sclerocornea (HP:0000647)0.97268505
129Chorioretinal coloboma (HP:0000567)0.97072047
130Progressive cerebellar ataxia (HP:0002073)0.94481375
131Recurrent sinusitis (HP:0011108)0.91016532
132Aplasia/Hypoplasia of the macula (HP:0008059)0.89616073
133Hypermetropia (HP:0000540)0.88343258
134Prolonged QT interval (HP:0001657)0.87334192
135Left ventricular hypertrophy (HP:0001712)0.86537069
136Genetic anticipation (HP:0003743)0.86492800
137Aplasia/Hypoplasia affecting the retina (HP:0008061)0.82816001
138Specific learning disability (HP:0001328)0.82358907
139Broad foot (HP:0001769)0.81692950
140Abnormality of dental color (HP:0011073)0.80900409
141Asthma (HP:0002099)0.78385295
142Decreased testicular size (HP:0008734)0.75443468
143Furrowed tongue (HP:0000221)0.74146748
144Septo-optic dysplasia (HP:0100842)0.73129228
145Depression (HP:0000716)0.72695035
146Hypoventilation (HP:0002791)0.70062811
147Abnormality of the parathyroid morphology (HP:0011766)0.68999129
148Abnormality of midbrain morphology (HP:0002418)0.68831840
149Molar tooth sign on MRI (HP:0002419)0.68831840
150Increased neuronal autofluorescent lipopigment (HP:0002074)0.67555722
151Macroorchidism (HP:0000053)0.67492858
152Postural instability (HP:0002172)0.66980812
153Supranuclear gaze palsy (HP:0000605)0.66916419
154Abnormal EKG (HP:0003115)0.66889185
155Abnormality of the lower motor neuron (HP:0002366)0.64294453
156Syncope (HP:0001279)0.62309077
157Anencephaly (HP:0002323)0.62103633
158Anophthalmia (HP:0000528)0.61293831
159Insomnia (HP:0100785)0.61220530
160Congenital hepatic fibrosis (HP:0002612)0.60991438
161Abnormality of the fingertips (HP:0001211)0.60842059
162Postaxial hand polydactyly (HP:0001162)0.60733608
163Increased cerebral lipofuscin (HP:0011813)0.59972611
164Corneal dystrophy (HP:0001131)0.59430012
165Lymphopenia (HP:0001888)0.59326596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.49591285
2PBK4.32041688
3MAP4K23.83055535
4TESK23.75190524
5PINK13.50435492
6OXSR13.43353960
7WNK33.37325209
8PLK43.15265690
9IRAK22.87033720
10TESK12.28445349
11ACVR1B2.25617251
12TXK2.22959181
13MAP3K102.19578961
14BMPR1B2.15640031
15MUSK2.02999235
16CDK192.02729362
17GRK111.2657893
18CAMK1G1.78117063
19ADRBK21.73884884
20ZAK1.64295335
21NEK11.62833067
22SIK21.61633550
23CDK121.61094602
24CAMK1D1.58662929
25PAK61.57219427
26DDR21.57019160
27SGK2231.55253561
28SGK4941.55253561
29STK381.54572226
30ADRBK11.44387357
31MARK11.43736167
32HIPK21.40106849
33TAOK31.33239821
34TAF11.32006535
35MAPK121.31987384
36BRD41.31601906
37EIF2AK31.31565378
38MAPK71.29810163
39ERBB21.22595048
40BCKDK1.21440130
41CAMKK21.19834289
42ICK1.18320171
43MAP3K41.17781069
44SGK21.12956259
45INSRR1.12497223
46CSNK1D1.11001510
47CAMKK11.10218400
48MAPK131.06952969
49PRKCH1.05994385
50STK391.04187814
51DAPK21.02055524
52PNCK1.00167802
53STK38L0.99967884
54SGK30.99811387
55WNK40.97296131
56PRKD30.91020641
57DYRK1A0.90464012
58ERBB30.89167050
59PRKCE0.84473441
60DYRK20.84149717
61PRKAA10.83169249
62RPS6KA40.82975467
63CAMK2D0.80895881
64FES0.77805718
65NUAK10.77095998
66WNK10.76354023
67LATS10.76076341
68PRKCB0.76052772
69DYRK1B0.74286174
70CDK30.74175209
71EPHA30.74088279
72PRKCZ0.74021717
73CDK90.73196711
74PRKAA20.66378436
75MAP2K70.65906617
76GRK70.65850052
77PDK10.65041728
78AKT30.64347433
79IRAK10.63844720
80PHKG10.63669454
81PHKG20.63669454
82PRPF4B0.63034135
83GRK50.62829697
84PIK3CG0.62321298
85RPS6KA30.61123306
86PLK20.60946469
87CASK0.58924126
88PRKD20.58895498
89CDK50.58215942
90MAP3K70.57627160
91SIK10.57462019
92SGK10.56350905
93PRKACG0.55583687
94CAMK40.54967901
95MAPK150.54744046
96GSK3B0.54529155
97CAMK10.53848679
98PRKG10.53843429
99MINK10.53379894
100PTK2B0.51973791
101MAP2K20.51637207
102MYLK0.51634515
103MAPK100.50300913
104MAPK90.48633137
105IKBKB0.47819174
106NEK20.47749718
107MAPK140.47590390
108PRKDC0.47230433
109TTK0.46705248
110MST40.44968381
111CSF1R0.44542032
112TRIM280.44313105
113STK110.44125946
114PDPK10.42528456
115AKT20.41169645
116CSNK1G20.40750324
117CDK10.40740523
118PLK30.39809058
119IGF1R0.38775580
120TNK20.38266903
121KIT0.36857083
122PKN10.36633248
123ALK0.36415151
124PRKCG0.35498586
125CAMK2A0.35467583
126CHUK0.34618589
127PRKACA0.34372589
128CSNK1G30.32351367
129MAP2K40.31874102
130TYK20.30978977
131ROCK10.30905176
132RPS6KB10.30625685
133MAPK80.30414079
134SCYL20.29825821
135FGFR20.29801556
136CSNK1A10.28608092
137CDC42BPA0.28047784
138PRKCA0.27633569
139ABL10.27013248
140PRKD10.26795297
141BRSK20.26559679
142UHMK10.26477029
143TRPM70.26470225
144PRKCQ0.26086859
145CSNK1G10.25657386
146CSNK1E0.25341077
147OBSCN0.25212607
148NTRK30.24985100
149MTOR0.24833966
150ATM0.23518534
151FER0.23173830
152MARK20.23127011
153MAPK30.22721077
154PAK30.22587834
155NLK0.22431826
156MAPK10.21870828
157CHEK10.21360420
158CDK150.20995416
159FYN0.20919496

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.33907407
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.54632297
3Butanoate metabolism_Homo sapiens_hsa006502.91735669
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.73736054
5Phototransduction_Homo sapiens_hsa0474415.5498100
6Synaptic vesicle cycle_Homo sapiens_hsa047211.89568357
7Tryptophan metabolism_Homo sapiens_hsa003801.85939920
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77540586
9Propanoate metabolism_Homo sapiens_hsa006401.67508277
10Olfactory transduction_Homo sapiens_hsa047401.53080501
11Selenocompound metabolism_Homo sapiens_hsa004501.49260549
12GABAergic synapse_Homo sapiens_hsa047271.42645310
13Linoleic acid metabolism_Homo sapiens_hsa005911.42497175
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38697287
15Type I diabetes mellitus_Homo sapiens_hsa049401.38202817
16Primary immunodeficiency_Homo sapiens_hsa053401.37538008
17Fatty acid metabolism_Homo sapiens_hsa012121.33805203
18Ether lipid metabolism_Homo sapiens_hsa005651.26613486
19Graft-versus-host disease_Homo sapiens_hsa053321.22953452
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21832460
21Fatty acid degradation_Homo sapiens_hsa000711.21416847
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.19900652
23Peroxisome_Homo sapiens_hsa041461.16202002
24Sulfur metabolism_Homo sapiens_hsa009201.15126901
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10538977
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10476460
27Allograft rejection_Homo sapiens_hsa053301.07920897
28Circadian rhythm_Homo sapiens_hsa047101.07584546
29Chemical carcinogenesis_Homo sapiens_hsa052041.06624693
30Autoimmune thyroid disease_Homo sapiens_hsa053201.06073127
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05764159
32Cholinergic synapse_Homo sapiens_hsa047251.00926923
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99165564
34Morphine addiction_Homo sapiens_hsa050320.98746374
35Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97286160
36Basal transcription factors_Homo sapiens_hsa030220.95385226
37Dorso-ventral axis formation_Homo sapiens_hsa043200.95332395
38Circadian entrainment_Homo sapiens_hsa047130.93924426
39Fanconi anemia pathway_Homo sapiens_hsa034600.92814274
40Antigen processing and presentation_Homo sapiens_hsa046120.92168694
41Nitrogen metabolism_Homo sapiens_hsa009100.90112775
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89896407
43Glutamatergic synapse_Homo sapiens_hsa047240.88865920
44Oxidative phosphorylation_Homo sapiens_hsa001900.88405537
45Regulation of autophagy_Homo sapiens_hsa041400.88279095
46beta-Alanine metabolism_Homo sapiens_hsa004100.87497872
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.85329142
48Protein export_Homo sapiens_hsa030600.85099587
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82488425
50Nicotine addiction_Homo sapiens_hsa050330.81189646
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80578376
52Dopaminergic synapse_Homo sapiens_hsa047280.79733741
53Insulin secretion_Homo sapiens_hsa049110.78537377
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76926982
55ABC transporters_Homo sapiens_hsa020100.76136198
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68841626
57Rheumatoid arthritis_Homo sapiens_hsa053230.67597326
58Serotonergic synapse_Homo sapiens_hsa047260.66193548
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64647570
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64428800
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63942990
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63792395
63Homologous recombination_Homo sapiens_hsa034400.60215708
64Oxytocin signaling pathway_Homo sapiens_hsa049210.58561176
65Tyrosine metabolism_Homo sapiens_hsa003500.57743350
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55759070
67PPAR signaling pathway_Homo sapiens_hsa033200.55606653
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52125935
69Salivary secretion_Homo sapiens_hsa049700.51793704
70Phenylalanine metabolism_Homo sapiens_hsa003600.51127897
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50650430
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50636766
73Long-term depression_Homo sapiens_hsa047300.50582011
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49467339
75Arginine and proline metabolism_Homo sapiens_hsa003300.48429768
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.48373886
77* Metabolic pathways_Homo sapiens_hsa011000.48042852
78Dilated cardiomyopathy_Homo sapiens_hsa054140.47384718
79Renin secretion_Homo sapiens_hsa049240.47201600
80Cardiac muscle contraction_Homo sapiens_hsa042600.47169904
81Caffeine metabolism_Homo sapiens_hsa002320.45525707
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43777712
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43130310
84Inositol phosphate metabolism_Homo sapiens_hsa005620.41435606
85cAMP signaling pathway_Homo sapiens_hsa040240.41244032
86Renin-angiotensin system_Homo sapiens_hsa046140.40984653
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40573908
88Gastric acid secretion_Homo sapiens_hsa049710.40532556
89Purine metabolism_Homo sapiens_hsa002300.40439140
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39909310
91Arachidonic acid metabolism_Homo sapiens_hsa005900.39047039
92Asthma_Homo sapiens_hsa053100.38927415
93Fructose and mannose metabolism_Homo sapiens_hsa000510.37746711
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37712113
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37371470
96mTOR signaling pathway_Homo sapiens_hsa041500.35276675
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34474857
98Glycerolipid metabolism_Homo sapiens_hsa005610.32884944
99Fat digestion and absorption_Homo sapiens_hsa049750.32490006
100Lysine degradation_Homo sapiens_hsa003100.32203855
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32157655
102Cocaine addiction_Homo sapiens_hsa050300.30346913
103Parkinsons disease_Homo sapiens_hsa050120.30239198
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30031875
105Hedgehog signaling pathway_Homo sapiens_hsa043400.30028115
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.29566459
107Long-term potentiation_Homo sapiens_hsa047200.29506644
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28688382
109Sphingolipid metabolism_Homo sapiens_hsa006000.28462935
110Bile secretion_Homo sapiens_hsa049760.27747186
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.27297449
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27119126
113Type II diabetes mellitus_Homo sapiens_hsa049300.27006871
114Glucagon signaling pathway_Homo sapiens_hsa049220.24820481
115Mineral absorption_Homo sapiens_hsa049780.23717954
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23248869
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23185025
118Fatty acid elongation_Homo sapiens_hsa000620.23025770
119Amphetamine addiction_Homo sapiens_hsa050310.22557619
120Calcium signaling pathway_Homo sapiens_hsa040200.22454182
121Arginine biosynthesis_Homo sapiens_hsa002200.22406437
122AMPK signaling pathway_Homo sapiens_hsa041520.19472838
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.19356688
124Pancreatic secretion_Homo sapiens_hsa049720.19058376
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18590086
126Thyroid hormone synthesis_Homo sapiens_hsa049180.18491585
127HIF-1 signaling pathway_Homo sapiens_hsa040660.18263720
128Alcoholism_Homo sapiens_hsa050340.17790105
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.17532132
130GnRH signaling pathway_Homo sapiens_hsa049120.17259817
131Chemokine signaling pathway_Homo sapiens_hsa040620.17044021
132Collecting duct acid secretion_Homo sapiens_hsa049660.15809623
133Biosynthesis of amino acids_Homo sapiens_hsa012300.15564239
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14819098
135MAPK signaling pathway_Homo sapiens_hsa040100.14533606
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14292284
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.14157164
138Galactose metabolism_Homo sapiens_hsa000520.12242822
139* Retinol metabolism_Homo sapiens_hsa008300.12027763
140Tight junction_Homo sapiens_hsa045300.11885994
141Ras signaling pathway_Homo sapiens_hsa040140.11574314
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09940797
143Hippo signaling pathway_Homo sapiens_hsa043900.09694658
144Renal cell carcinoma_Homo sapiens_hsa052110.09623421
145Choline metabolism in cancer_Homo sapiens_hsa052310.09351621
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.08867140
147Taste transduction_Homo sapiens_hsa047420.08435654
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.08221359
149Gap junction_Homo sapiens_hsa045400.08065987
150Vibrio cholerae infection_Homo sapiens_hsa051100.07920189
151Glioma_Homo sapiens_hsa052140.07704996
152Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07656955
153Insulin resistance_Homo sapiens_hsa049310.07266222
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07110981
155Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06986331
156Wnt signaling pathway_Homo sapiens_hsa043100.06574993
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06321469
158Endocytosis_Homo sapiens_hsa041440.05458185
159mRNA surveillance pathway_Homo sapiens_hsa030150.05322218
160Fatty acid biosynthesis_Homo sapiens_hsa000610.05192021

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