RDH11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.44624576
2L-phenylalanine catabolic process (GO:0006559)6.44624576
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.98404418
4L-phenylalanine metabolic process (GO:0006558)5.98404418
5alpha-linolenic acid metabolic process (GO:0036109)5.90244741
6fatty acid elongation (GO:0030497)5.90039244
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.49851861
8cholesterol biosynthetic process (GO:0006695)5.39684146
9aromatic amino acid family catabolic process (GO:0009074)5.33358212
10high-density lipoprotein particle remodeling (GO:0034375)5.06867477
11cysteine metabolic process (GO:0006534)5.01560775
12bile acid biosynthetic process (GO:0006699)4.98789234
13negative regulation of fibrinolysis (GO:0051918)4.88336951
14urea cycle (GO:0000050)4.84523220
15urea metabolic process (GO:0019627)4.84523220
16sterol biosynthetic process (GO:0016126)4.77321467
17regulation of cholesterol esterification (GO:0010872)4.70759406
18glyoxylate metabolic process (GO:0046487)4.70717529
19long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.64820230
20sulfur amino acid catabolic process (GO:0000098)4.59597990
21water-soluble vitamin biosynthetic process (GO:0042364)4.58187071
22regulation of fibrinolysis (GO:0051917)4.57535479
23fatty-acyl-CoA biosynthetic process (GO:0046949)4.57176397
24plasma lipoprotein particle clearance (GO:0034381)4.53840924
25reverse cholesterol transport (GO:0043691)4.44523275
26protein neddylation (GO:0045116)4.43413241
27tryptophan catabolic process (GO:0006569)4.39013163
28indole-containing compound catabolic process (GO:0042436)4.39013163
29indolalkylamine catabolic process (GO:0046218)4.39013163
30kynurenine metabolic process (GO:0070189)4.37092973
31nitrogen cycle metabolic process (GO:0071941)4.36682145
32fusion of sperm to egg plasma membrane (GO:0007342)4.34000167
33protein-lipid complex remodeling (GO:0034368)4.32886291
34macromolecular complex remodeling (GO:0034367)4.32886291
35plasma lipoprotein particle remodeling (GO:0034369)4.32886291
36peptidyl-glutamic acid carboxylation (GO:0017187)4.31713296
37protein carboxylation (GO:0018214)4.31713296
38bile acid metabolic process (GO:0008206)4.30516069
39very-low-density lipoprotein particle assembly (GO:0034379)4.30224100
40serine family amino acid biosynthetic process (GO:0009070)4.28613311
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.26772756
42ethanol oxidation (GO:0006069)4.23945577
43regulation of triglyceride catabolic process (GO:0010896)4.22101083
44L-serine metabolic process (GO:0006563)4.14215989
45complement activation, alternative pathway (GO:0006957)4.13137877
46very long-chain fatty acid metabolic process (GO:0000038)4.11803031
47tryptophan metabolic process (GO:0006568)4.09609853
48plasma lipoprotein particle assembly (GO:0034377)4.05832968
49regulation of protein activation cascade (GO:2000257)4.04265808
50coenzyme catabolic process (GO:0009109)4.03946942
51phospholipid efflux (GO:0033700)4.01718274
52negative regulation of cholesterol transport (GO:0032375)4.00535283
53negative regulation of sterol transport (GO:0032372)4.00535283
54thioester biosynthetic process (GO:0035384)4.00136371
55acyl-CoA biosynthetic process (GO:0071616)4.00136371
56cholesterol efflux (GO:0033344)3.97427794
57tyrosine metabolic process (GO:0006570)3.97100689
58triglyceride homeostasis (GO:0070328)3.95410632
59acylglycerol homeostasis (GO:0055090)3.95410632
60cilium or flagellum-dependent cell motility (GO:0001539)3.94505639
61sperm motility (GO:0030317)3.90989704
62low-density lipoprotein particle remodeling (GO:0034374)3.90833330
63protein-lipid complex assembly (GO:0065005)3.89439790
64cofactor catabolic process (GO:0051187)3.87462941
65heme transport (GO:0015886)3.86611232
66fatty-acyl-CoA metabolic process (GO:0035337)3.83994130
67aldehyde catabolic process (GO:0046185)3.80151412
68cellular glucuronidation (GO:0052695)3.79830452
69serine family amino acid catabolic process (GO:0009071)3.79265053
70serine family amino acid metabolic process (GO:0009069)3.78636049
71long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.78078317
72homocysteine metabolic process (GO:0050667)3.77948422
73fibrinolysis (GO:0042730)3.76285985
74aromatic amino acid family metabolic process (GO:0009072)3.74963050
75acetyl-CoA metabolic process (GO:0006084)3.74679976
76amino-acid betaine metabolic process (GO:0006577)3.70661843
77regulation of complement activation (GO:0030449)3.68542834
78multicellular organism reproduction (GO:0032504)3.65349027
79sperm-egg recognition (GO:0035036)3.61997156
80bile acid and bile salt transport (GO:0015721)3.61410103
81ethanol metabolic process (GO:0006067)3.61308191
82alpha-amino acid catabolic process (GO:1901606)3.59633266
83negative regulation of lipase activity (GO:0060192)3.58577033
84cellular ketone body metabolic process (GO:0046950)3.55916917
85cholesterol homeostasis (GO:0042632)3.54298890
86acyl-CoA metabolic process (GO:0006637)3.54070708
87thioester metabolic process (GO:0035383)3.54070708
88response to methylmercury (GO:0051597)3.51318862
89piRNA metabolic process (GO:0034587)3.50702945
90sterol homeostasis (GO:0055092)3.50621360
91cholesterol metabolic process (GO:0008203)3.49488981
92glycine metabolic process (GO:0006544)3.48077276
93glutamate metabolic process (GO:0006536)3.47338553
94plasma lipoprotein particle organization (GO:0071827)3.46881457
95response to nitrosative stress (GO:0051409)3.45846692
96regulation of cholesterol biosynthetic process (GO:0045540)3.44869206
97acrosome assembly (GO:0001675)3.43621494
98binding of sperm to zona pellucida (GO:0007339)3.41598919
99protein-lipid complex subunit organization (GO:0071825)3.41166160
100linoleic acid metabolic process (GO:0043651)3.40245792
101regulation of plasminogen activation (GO:0010755)3.38524963
102aspartate family amino acid catabolic process (GO:0009068)3.36578682
103branched-chain amino acid catabolic process (GO:0009083)3.13081027
104biotin metabolic process (GO:0006768)3.07866928
105establishment of protein localization to mitochondrial membrane (GO:0090151)2.88122289
106protein complex biogenesis (GO:0070271)2.86381179
107chaperone-mediated protein transport (GO:0072321)2.74474059
108mitochondrial respiratory chain complex assembly (GO:0033108)2.72303904
109vitamin biosynthetic process (GO:0009110)2.65736425
110DNA double-strand break processing (GO:0000729)2.64882320
111mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63465932
112respiratory chain complex IV assembly (GO:0008535)2.61235693
113blood coagulation, intrinsic pathway (GO:0007597)2.57369789
114negative regulation of appetite (GO:0032099)2.56344821
115negative regulation of response to food (GO:0032096)2.56344821
116mitochondrial respiratory chain complex I assembly (GO:0032981)2.54893172
117NADH dehydrogenase complex assembly (GO:0010257)2.54893172
118mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54893172
119lysine catabolic process (GO:0006554)2.54449348
120lysine metabolic process (GO:0006553)2.54449348
121proteasome assembly (GO:0043248)2.54419483
122regulation of mitochondrial translation (GO:0070129)2.52433963
123isoprenoid biosynthetic process (GO:0008299)2.50237226
124prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.49433861
125negative regulation of membrane potential (GO:0045837)2.47567996
126presynaptic membrane assembly (GO:0097105)2.47465128
127regulation of hexokinase activity (GO:1903299)2.47218582
128regulation of glucokinase activity (GO:0033131)2.47218582
129protein-cofactor linkage (GO:0018065)2.43033518
130mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41499512
131protein autoprocessing (GO:0016540)2.40874976
132branching involved in prostate gland morphogenesis (GO:0060442)2.38384445
133negative regulation of protein localization to cell surface (GO:2000009)2.33399589
134cullin deneddylation (GO:0010388)2.33005761
135behavioral response to nicotine (GO:0035095)2.31577551
136coenzyme A metabolic process (GO:0015936)2.31463624
137anterior/posterior axis specification, embryo (GO:0008595)2.31377698
138adenosine metabolic process (GO:0046085)2.30703910
139magnesium ion transport (GO:0015693)2.29743760
140lactate metabolic process (GO:0006089)2.29217923
141cytochrome complex assembly (GO:0017004)2.28725824
142protein deneddylation (GO:0000338)2.24821507
143presynaptic membrane organization (GO:0097090)2.17959473
144transcription elongation from RNA polymerase III promoter (GO:0006385)2.16950245
145termination of RNA polymerase III transcription (GO:0006386)2.16950245
146telomere maintenance via telomerase (GO:0007004)2.16838871
147zinc ion transport (GO:0006829)2.16425352
148nonmotile primary cilium assembly (GO:0035058)2.15086576
149dopamine transport (GO:0015872)2.14707544
150branched-chain amino acid metabolic process (GO:0009081)2.10854478
151purine nucleobase biosynthetic process (GO:0009113)2.09415931
152long-chain fatty acid biosynthetic process (GO:0042759)2.09176200
153L-alpha-amino acid transmembrane transport (GO:1902475)2.08733114
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.08344543
155nucleotide-sugar biosynthetic process (GO:0009226)2.08026757
156L-methionine biosynthetic process (GO:0071265)2.07185378
157amino acid salvage (GO:0043102)2.07185378
158L-methionine salvage (GO:0071267)2.07185378
159pteridine-containing compound metabolic process (GO:0042558)2.07114687
160glycerophospholipid catabolic process (GO:0046475)2.06623006
161peroxisome fission (GO:0016559)2.06116929
162zinc ion transmembrane transport (GO:0071577)2.05796976
163chromatin remodeling at centromere (GO:0031055)2.05396773
164establishment of integrated proviral latency (GO:0075713)2.04991169
165dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.04939587
166regulation of response to food (GO:0032095)2.03527883
167intracellular protein transmembrane import (GO:0044743)2.03162938
168CENP-A containing nucleosome assembly (GO:0034080)2.03138862
169regulation of cellular amino acid metabolic process (GO:0006521)2.03094913
170maturation of 5.8S rRNA (GO:0000460)2.03087171
171sulfur amino acid biosynthetic process (GO:0000097)2.00507527
172nucleoside bisphosphate metabolic process (GO:0033865)1.99466454
173purine nucleoside bisphosphate metabolic process (GO:0034032)1.99466454
174ribonucleoside bisphosphate metabolic process (GO:0033875)1.99466454
175pteridine-containing compound biosynthetic process (GO:0042559)1.98259028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.76994853
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.16578337
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.74463706
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.66356238
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.56479544
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.08354039
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.88411612
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.66538382
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21149325
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.11990002
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.74761311
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.70167538
13GBX2_23144817_ChIP-Seq_PC3_Human2.46920043
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.22949270
15* EST1_17652178_ChIP-ChIP_JURKAT_Human2.20664189
16IGF1R_20145208_ChIP-Seq_DFB_Human2.19058231
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18240380
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10939368
19ELK1_19687146_ChIP-ChIP_HELA_Human2.08102092
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02375763
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1463402
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96196636
23ZNF274_21170338_ChIP-Seq_K562_Hela1.94665574
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84041290
25EWS_26573619_Chip-Seq_HEK293_Human1.83701339
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72668830
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66097200
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64195215
29HTT_18923047_ChIP-ChIP_STHdh_Human1.63607346
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.62045529
31P300_19829295_ChIP-Seq_ESCs_Human1.60837777
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.59513555
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58560727
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56669821
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53729903
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51172780
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50651017
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.48021819
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46098506
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45519271
41IRF1_19129219_ChIP-ChIP_H3396_Human1.43491516
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42254362
43FUS_26573619_Chip-Seq_HEK293_Human1.41846985
44* ETS1_20019798_ChIP-Seq_JURKAT_Human1.41151455
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37651729
46NANOG_16153702_ChIP-ChIP_HESCs_Human1.37629073
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35709357
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35304247
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35193443
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35072523
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32921794
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32636496
53KAP1_22055183_ChIP-Seq_ESCs_Mouse1.31606749
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29878108
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25868658
56MYC_18940864_ChIP-ChIP_HL60_Human1.24734836
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.24020123
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22456644
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21817872
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21540697
61* SOX2_16153702_ChIP-ChIP_HESCs_Human1.21359364
62HNF4A_19822575_ChIP-Seq_HepG2_Human1.21332640
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20915596
64* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20644730
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20256671
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20027068
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19447620
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18038062
69SMAD4_21799915_ChIP-Seq_A2780_Human1.16654269
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15121186
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14652608
72AR_21909140_ChIP-Seq_LNCAP_Human1.13861406
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12405272
74VDR_23849224_ChIP-Seq_CD4+_Human1.12300805
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11848577
76RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07237007
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07091342
78AR_25329375_ChIP-Seq_VCAP_Human1.06770950
79* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06064119
80* CLOCK_20551151_ChIP-Seq_293T_Human1.04990970
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04814513
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04648533
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04258836
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04211091
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03759493
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02780569
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02519527
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02361221
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01839281
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01557472
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99715655
92FOXO3_23340844_ChIP-Seq_DLD1_Human0.98796198
93ERG_20517297_ChIP-Seq_VCAP_Human0.97801473
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97655844
95STAT1_17558387_ChIP-Seq_HELA_Human0.97553350
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97024962
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96525685
98* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96148347
99* GATA4_25053715_ChIP-Seq_YYC3_Human0.94562215
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94389712
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94238104
102* EOMES_21245162_ChIP-Seq_HESCs_Human0.93335902
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92208508
104NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91692905
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.91483321
106TAL1_26923725_Chip-Seq_HPCs_Mouse0.91453767
107* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91178473
108NANOG_18555785_Chip-Seq_ESCs_Mouse0.91175963
109SMAD3_21741376_ChIP-Seq_EPCs_Human0.90697627
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90589960
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90520090
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90420242
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90157377
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90019766
115JUN_21703547_ChIP-Seq_K562_Human0.89757232
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89160181
117RNF2_27304074_Chip-Seq_NSC_Mouse0.89144651
118TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88935110
119TAF15_26573619_Chip-Seq_HEK293_Human0.88296122
120* P53_21459846_ChIP-Seq_SAOS-2_Human0.88237603
121* AR_20517297_ChIP-Seq_VCAP_Human0.88082569
122TP53_22573176_ChIP-Seq_HFKS_Human0.87253750
123* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87134744
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86812566
125CBP_21632823_ChIP-Seq_H3396_Human0.85440767
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85007839
127* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83120773
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82225698
129CDX2_22108803_ChIP-Seq_LS180_Human0.82130746
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81539408
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81018452
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.80232198
133CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79971925
134KDM2B_26808549_Chip-Seq_REH_Human0.79175738
135ZNF263_19887448_ChIP-Seq_K562_Human0.78593532
136FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78147193
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.77817006
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.76843422
139SOX2_22085726_ChIP-Seq_NPCs_Mouse0.74156066
140LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.74076444
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73636162
142BCAT_22108803_ChIP-Seq_LS180_Human0.73399328
143TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73099648
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72897097
145CEBPB_22108803_ChIP-Seq_LS180_Human0.72654145
146GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.72606817
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.70535148
148PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70392815
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69202523
150NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69202523
151RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68695582
152SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68238098
153VDR_22108803_ChIP-Seq_LS180_Human0.67848723
154E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.67157306
155FLI1_27457419_Chip-Seq_LIVER_Mouse0.66987716
156MYC_19915707_ChIP-ChIP_AK7_Human0.66814154
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.65738378
158TP63_23658742_ChIP-Seq_EP156T_Human0.65462659
159JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65428003
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.65163638
161NCOR_22424771_ChIP-Seq_293T_Human0.64914687
162CBP_20019798_ChIP-Seq_JUKART_Human0.64213235
163IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.64213235
164RARA_24833708_ChIP-Seq_LIVER_Mouse0.63887467
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.62325320
166NANOG_20526341_ChIP-Seq_ESCs_Human0.61803361
167FLI1_21867929_ChIP-Seq_TH2_Mouse0.61637384
168NFE2_27457419_Chip-Seq_LIVER_Mouse0.60723705
169SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.60496143
170STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.60060896
171ER_23166858_ChIP-Seq_MCF-7_Human0.59819464
172EZH2_27294783_Chip-Seq_NPCs_Mouse0.59599308
173* FOXA1_25552417_ChIP-Seq_VCAP_Human0.59215621
174PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.59098619
175GATA3_21867929_ChIP-Seq_TH1_Mouse0.58869463
176PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58819901
177FOXA1_21572438_ChIP-Seq_LNCaP_Human0.57462292
178SUZ12_27294783_Chip-Seq_NPCs_Mouse0.57126642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.01696633
2MP0005360_urolithiasis6.52967263
3MP0005085_abnormal_gallbladder_physiolo5.27208204
4MP0005365_abnormal_bile_salt5.21952768
5MP0008875_abnormal_xenobiotic_pharmacok4.48826208
6MP0005410_abnormal_fertilization4.41406424
7MP0003806_abnormal_nucleotide_metabolis4.36218412
8MP0009840_abnormal_foam_cell3.72133120
9MP0010329_abnormal_lipoprotein_level3.18764531
10MP0005083_abnormal_biliary_tract3.10931051
11MP0003252_abnormal_bile_duct3.03514352
12MP0003122_maternal_imprinting2.80039185
13MP0002736_abnormal_nociception_after2.67558244
14MP0005332_abnormal_amino_acid2.28778291
15MP0003121_genomic_imprinting2.15341993
16MP0001666_abnormal_nutrient_absorption2.14621161
17MP0002102_abnormal_ear_morphology2.12828877
18MP0003656_abnormal_erythrocyte_physiolo2.08546928
19MP0003195_calcinosis2.08539253
20MP0005451_abnormal_body_composition2.02600597
21MP0002118_abnormal_lipid_homeostasis2.01118616
22MP0003329_amyloid_beta_deposits2.00897297
23* MP0003011_delayed_dark_adaptation1.99571517
24MP0000604_amyloidosis1.97085004
25MP0003941_abnormal_skin_development1.96604926
26MP0008877_abnormal_DNA_methylation1.96351933
27MP0000609_abnormal_liver_physiology1.91634960
28MP0006072_abnormal_retinal_apoptosis1.90565781
29MP0002938_white_spotting1.89876415
30MP0003191_abnormal_cellular_cholesterol1.85122265
31MP0003123_paternal_imprinting1.83803550
32MP0004019_abnormal_vitamin_homeostasis1.78536945
33MP0002837_dystrophic_cardiac_calcinosis1.78075012
34MP0001968_abnormal_touch/_nociception1.69644661
35MP0002909_abnormal_adrenal_gland1.65390955
36MP0005584_abnormal_enzyme/coenzyme_acti1.64795627
37MP0000537_abnormal_urethra_morphology1.63684980
38MP0003950_abnormal_plasma_membrane1.58619606
39MP0003690_abnormal_glial_cell1.58583846
40MP0001188_hyperpigmentation1.57002323
41MP0001984_abnormal_olfaction1.56788101
42MP0008789_abnormal_olfactory_epithelium1.56289064
43MP0009780_abnormal_chondrocyte_physiolo1.55091447
44MP0003787_abnormal_imprinting1.54869770
45MP0003868_abnormal_feces_composition1.52952863
46MP0009697_abnormal_copulation1.45121795
47MP0008058_abnormal_DNA_repair1.43588133
48MP0003698_abnormal_male_reproductive1.41640117
49MP0001764_abnormal_homeostasis1.40446263
50MP0010386_abnormal_urinary_bladder1.39724840
51MP0001929_abnormal_gametogenesis1.36006003
52MP0003937_abnormal_limbs/digits/tail_de1.34867805
53MP0002876_abnormal_thyroid_physiology1.33267694
54MP0003186_abnormal_redox_activity1.32818412
55MP0005319_abnormal_enzyme/_coenzyme1.32514720
56MP0005499_abnormal_olfactory_system1.30802572
57MP0005394_taste/olfaction_phenotype1.30802572
58MP0000920_abnormal_myelination1.29658286
59MP0001485_abnormal_pinna_reflex1.28743838
60MP0005408_hypopigmentation1.27687423
61MP0005379_endocrine/exocrine_gland_phen1.23832899
62MP0008932_abnormal_embryonic_tissue1.23027040
63MP0002138_abnormal_hepatobiliary_system1.15736748
64MP0003693_abnormal_embryo_hatching1.15437569
65MP0002234_abnormal_pharynx_morphology1.14522208
66MP0002254_reproductive_system_inflammat1.12204714
67MP0003119_abnormal_digestive_system1.11008924
68MP0002557_abnormal_social/conspecific_i1.10010197
69MP0002160_abnormal_reproductive_system1.09753783
70MP0004133_heterotaxia1.09385975
71MP0005084_abnormal_gallbladder_morpholo1.08164152
72MP0005647_abnormal_sex_gland1.07196305
73MP0002233_abnormal_nose_morphology1.05556401
74MP0006292_abnormal_olfactory_placode1.05155038
75* MP0005253_abnormal_eye_physiology1.05148391
76MP0009384_cardiac_valve_regurgitation1.04235882
77MP0001919_abnormal_reproductive_system1.02196422
78MP0002282_abnormal_trachea_morphology1.01280307
79MP0002272_abnormal_nervous_system0.99364968
80MP0002653_abnormal_ependyma_morphology0.99308529
81MP0000631_abnormal_neuroendocrine_gland0.98509756
82MP0004957_abnormal_blastocyst_morpholog0.98041880
83MP0000598_abnormal_liver_morphology0.97678610
84MP0005187_abnormal_penis_morphology0.97041732
85MP0005389_reproductive_system_phenotype0.96591959
86MP0008007_abnormal_cellular_replicative0.95494358
87MP0001756_abnormal_urination0.94217779
88MP0003718_maternal_effect0.92987649
89MP0006276_abnormal_autonomic_nervous0.91599488
90MP0008872_abnormal_physiological_respon0.91006942
91MP0006035_abnormal_mitochondrial_morpho0.90967394
92MP0005645_abnormal_hypothalamus_physiol0.90418228
93MP0003315_abnormal_perineum_morphology0.88812685
94MP0002161_abnormal_fertility/fecundity0.87431604
95MP0002735_abnormal_chemical_nociception0.86558693
96MP0009046_muscle_twitch0.86458374
97MP0000639_abnormal_adrenal_gland0.86453743
98MP0009763_increased_sensitivity_to0.86237763
99MP0003880_abnormal_central_pattern0.84727948
100MP0001293_anophthalmia0.83724255
101MP0000538_abnormal_urinary_bladder0.83711094
102MP0005636_abnormal_mineral_homeostasis0.83506446
103MP0003632_abnormal_nervous_system0.82523812
104MP0000778_abnormal_nervous_system0.79544823
105MP0000383_abnormal_hair_follicle0.78099014
106MP0009643_abnormal_urine_homeostasis0.78030190
107MP0003705_abnormal_hypodermis_morpholog0.77322227
108MP0010094_abnormal_chromosome_stability0.77059924
109MP0002638_abnormal_pupillary_reflex0.76267180
110MP0000647_abnormal_sebaceous_gland0.75544741
111MP0002734_abnormal_mechanical_nocicepti0.75279858
112MP0002751_abnormal_autonomic_nervous0.75168628
113MP0001286_abnormal_eye_development0.72728751
114MP0002796_impaired_skin_barrier0.72464288
115MP0003755_abnormal_palate_morphology0.72211193
116MP0001944_abnormal_pancreas_morphology0.71731167
117MP0002572_abnormal_emotion/affect_behav0.70306837
118MP0000230_abnormal_systemic_arterial0.70050195
119MP0004142_abnormal_muscle_tone0.69917959
120MP0000516_abnormal_urinary_system0.69726946
121MP0005367_renal/urinary_system_phenotyp0.69726946
122MP0000653_abnormal_sex_gland0.67261826
123MP0005376_homeostasis/metabolism_phenot0.66881475
124MP0002210_abnormal_sex_determination0.66469886
125MP0001145_abnormal_male_reproductive0.65922628
126MP0004381_abnormal_hair_follicle0.64617938
127MP0001324_abnormal_eye_pigmentation0.63682477
128MP0008873_increased_physiological_sensi0.62418350
129MP0008469_abnormal_protein_level0.61809435
130MP0009642_abnormal_blood_homeostasis0.61134061
131MP0009765_abnormal_xenobiotic_induced0.59090879
132MP0005395_other_phenotype0.56999056
133MP0003136_yellow_coat_color0.55328341
134MP0004134_abnormal_chest_morphology0.55232118
135MP0000462_abnormal_digestive_system0.55026527
136MP0003634_abnormal_glial_cell0.54827111
137MP0009764_decreased_sensitivity_to0.54116580
138MP0002971_abnormal_brown_adipose0.52338854
139MP0001661_extended_life_span0.51489712
140MP0001529_abnormal_vocalization0.51445616
141MP0000427_abnormal_hair_cycle0.51047765
142MP0003075_altered_response_to0.50845882
143MP0002295_abnormal_pulmonary_circulatio0.50184757
144MP0006036_abnormal_mitochondrial_physio0.46294672
145MP0006082_CNS_inflammation0.46171127
146MP0005464_abnormal_platelet_physiology0.44908136
147MP0000579_abnormal_nail_morphology0.44556273
148MP0002090_abnormal_vision0.43717387
149MP0003631_nervous_system_phenotype0.43254994
150MP0005646_abnormal_pituitary_gland0.41809135
151MP0005164_abnormal_response_to0.41600546
152MP0002092_abnormal_eye_morphology0.41005311
153MP0003890_abnormal_embryonic-extraembry0.40475910
154MP0005058_abnormal_lysosome_morphology0.40231021
155* MP0005551_abnormal_eye_electrophysiolog0.38801325
156MP0002229_neurodegeneration0.38724719
157MP0003699_abnormal_female_reproductive0.38668521
158MP0001243_abnormal_dermal_layer0.37920335
159MP0005220_abnormal_exocrine_pancreas0.37802084
160MP0005266_abnormal_metabolism0.37651221
161MP0001340_abnormal_eyelid_morphology0.37497363
162MP0001851_eye_inflammation0.37489945
163MP0009053_abnormal_anal_canal0.36829682
164MP0010678_abnormal_skin_adnexa0.35812151
165MP0005334_abnormal_fat_pad0.35212546
166MP0003453_abnormal_keratinocyte_physiol0.35186641
167MP0005195_abnormal_posterior_eye0.34949978
168MP0004885_abnormal_endolymph0.34122257
169MP0005248_abnormal_Harderian_gland0.33746743
170MP0004270_analgesia0.32018819

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.92871118
2Deep venous thrombosis (HP:0002625)6.30855539
3Hypobetalipoproteinemia (HP:0003563)5.76704006
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.70831082
5Xanthomatosis (HP:0000991)5.54989837
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.35111249
7Prolonged partial thromboplastin time (HP:0003645)5.06055312
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.86421210
9Abnormal gallbladder physiology (HP:0012438)4.79661392
10Cholecystitis (HP:0001082)4.79661392
11Hyperlipoproteinemia (HP:0010980)4.58095513
12Epidermoid cyst (HP:0200040)4.17490785
13Hypolipoproteinemia (HP:0010981)4.16896298
14Abnormality of methionine metabolism (HP:0010901)4.11447961
15Absent/shortened dynein arms (HP:0200106)3.90628581
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.90628581
17Complement deficiency (HP:0004431)3.81790306
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.81600289
19Fat malabsorption (HP:0002630)3.80796984
20Neurofibrillary tangles (HP:0002185)3.69372789
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.64786332
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.63089756
23Acanthocytosis (HP:0001927)3.54750699
24Abnormality of the common coagulation pathway (HP:0010990)3.40381499
25Hyperammonemia (HP:0001987)3.33330052
26Hypoalphalipoproteinemia (HP:0003233)3.32782638
27Joint hemorrhage (HP:0005261)3.25127032
28Methylmalonic acidemia (HP:0002912)3.23181423
29Abnormality of the labia minora (HP:0012880)3.22544026
30Hypercholesterolemia (HP:0003124)3.15099652
31Cerebral inclusion bodies (HP:0100314)3.04885532
32Steatorrhea (HP:0002570)3.02268742
33Spontaneous abortion (HP:0005268)3.00352702
34Hypoglycemic seizures (HP:0002173)2.95394580
35Hyperglycinemia (HP:0002154)2.90067035
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.90046735
37Abnormal respiratory motile cilium physiology (HP:0012261)2.88196560
38Upper motor neuron abnormality (HP:0002127)2.87423843
39Acute encephalopathy (HP:0006846)2.80604565
40Ketosis (HP:0001946)2.78305751
41Hyperbilirubinemia (HP:0002904)2.75944157
42Acute necrotizing encephalopathy (HP:0006965)2.75119067
43Abnormality of complement system (HP:0005339)2.74642999
44Abnormality of the intrinsic pathway (HP:0010989)2.72994122
45Abnormal gallbladder morphology (HP:0012437)2.72068044
46Abnormality of glycine metabolism (HP:0010895)2.70864188
47Abnormality of serine family amino acid metabolism (HP:0010894)2.70864188
48Vascular calcification (HP:0004934)2.69312769
49Hyperinsulinemic hypoglycemia (HP:0000825)2.68296970
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.58974943
51Rhinitis (HP:0012384)2.51356576
52Methylmalonic aciduria (HP:0012120)2.49357052
53Conjugated hyperbilirubinemia (HP:0002908)2.46746358
54Progressive macrocephaly (HP:0004481)2.42643094
55Amyloidosis (HP:0011034)2.41181575
56Abnormality of pyrimidine metabolism (HP:0004353)2.40265935
57Infertility (HP:0000789)2.38122261
58Cholelithiasis (HP:0001081)2.38052419
59Cardiovascular calcification (HP:0011915)2.33905791
60Hepatocellular carcinoma (HP:0001402)2.31593646
61Abnormal mitochondria in muscle tissue (HP:0008316)2.31539321
62Protuberant abdomen (HP:0001538)2.30779781
63Ketoacidosis (HP:0001993)2.28564184
64Abnormality of the gallbladder (HP:0005264)2.27576036
65Increased serum pyruvate (HP:0003542)2.26705615
66Abnormality of glycolysis (HP:0004366)2.26705615
67Symptomatic seizures (HP:0011145)2.24997403
68Abnormal respiratory motile cilium morphology (HP:0005938)2.24897804
69Abnormal respiratory epithelium morphology (HP:0012253)2.24897804
70Chronic bronchitis (HP:0004469)2.22854029
71Malnutrition (HP:0004395)2.21532577
72Abnormality of serum amino acid levels (HP:0003112)2.21521761
73Poor suck (HP:0002033)2.21156283
74Lipid accumulation in hepatocytes (HP:0006561)2.19795663
75Myocardial infarction (HP:0001658)2.19656252
76Renal cortical cysts (HP:0000803)2.19575261
77Pancreatic islet-cell hyperplasia (HP:0004510)2.17080209
783-Methylglutaconic aciduria (HP:0003535)2.14087317
79Renal Fanconi syndrome (HP:0001994)2.13313221
80Vitreoretinal degeneration (HP:0000655)2.12443709
81Mitochondrial inheritance (HP:0001427)2.12059312
82Abnormality of fatty-acid metabolism (HP:0004359)2.09729148
83Abnormal tarsal ossification (HP:0008369)2.08984739
84Increased hepatocellular lipid droplets (HP:0006565)2.08057366
85Skin nodule (HP:0200036)2.07259737
86Hypothermia (HP:0002045)2.06975592
87Hypophosphatemic rickets (HP:0004912)2.06811263
88True hermaphroditism (HP:0010459)2.05497772
89Cerebral edema (HP:0002181)2.05278098
90Spastic paraparesis (HP:0002313)2.02106077
91Short tibia (HP:0005736)2.01905514
92Pancreatic fibrosis (HP:0100732)2.01234482
93Abolished electroretinogram (ERG) (HP:0000550)2.00844406
94Adrenal hypoplasia (HP:0000835)2.00808982
95Hyperglycinuria (HP:0003108)1.99869868
96Hypoglycemic coma (HP:0001325)1.98673978
97Brushfield spots (HP:0001088)1.98602868
98Increased CSF lactate (HP:0002490)1.98491319
99Medial flaring of the eyebrow (HP:0010747)1.98419994
100Abnormality of the lower motor neuron (HP:0002366)1.95494260
101Irritability (HP:0000737)1.94719050
102Lethargy (HP:0001254)1.94483211
103Pancreatic cysts (HP:0001737)1.93658454
104Aplasia/Hypoplasia of the tibia (HP:0005772)1.93432196
105Abnormality of nucleobase metabolism (HP:0010932)1.93039653
106Hemorrhage of the eye (HP:0011885)1.92249567
107Rickets (HP:0002748)1.92212094
108Abnormality of endocrine pancreas physiology (HP:0012093)1.91664422
109Abnormality of the pancreatic islet cells (HP:0006476)1.91664422
110Bifid tongue (HP:0010297)1.91067389
111Spastic diplegia (HP:0001264)1.90933199
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88351266
113Abnormality of alanine metabolism (HP:0010916)1.88351266
114Hyperalaninemia (HP:0003348)1.88351266
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87489557
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.87489557
117Parakeratosis (HP:0001036)1.87112704
118Abnormal ciliary motility (HP:0012262)1.86565569
119Hepatic necrosis (HP:0002605)1.85850789
120Esophageal varix (HP:0002040)1.85558490
121Scrotal hypoplasia (HP:0000046)1.85385737
122Spastic tetraparesis (HP:0001285)1.84213503
123Epiphyseal dysplasia (HP:0002656)1.83870451
124Genital tract atresia (HP:0001827)1.83127837
125Gait imbalance (HP:0002141)1.83049247
126Abnormal lung lobation (HP:0002101)1.82492919
127Polyphagia (HP:0002591)1.81295235
128Hypoplastic pelvis (HP:0008839)1.80789504
129Paraparesis (HP:0002385)1.79758378
130Abnormal cartilage morphology (HP:0002763)1.79189774
131Congenital primary aphakia (HP:0007707)1.78856358
132Vaginal atresia (HP:0000148)1.77314991
133Cone-rod dystrophy (HP:0000548)1.76536777
134Pendular nystagmus (HP:0012043)1.75852563
135Irregular epiphyses (HP:0010582)1.74892830
136Septate vagina (HP:0001153)1.74416550
137Abnormality of the corticospinal tract (HP:0002492)1.74290135
138Increased mean platelet volume (HP:0011877)1.74131921
139Menorrhagia (HP:0000132)1.73651461
140Abnormality of the vitreous humor (HP:0004327)1.72247117
141Vertebral clefting (HP:0008428)1.72064216
142Sensory axonal neuropathy (HP:0003390)1.71959858
143Abnormality of vitamin metabolism (HP:0100508)1.71852236
144Aplasia/hypoplasia of the uterus (HP:0008684)1.71457397
145Delayed CNS myelination (HP:0002188)1.70248017
146Homocystinuria (HP:0002156)1.69914255
147Abnormality of homocysteine metabolism (HP:0010919)1.69914255
148Poikilocytosis (HP:0004447)1.69643559
149Abnormality of purine metabolism (HP:0004352)1.69426512
150Abnormality of vitamin B metabolism (HP:0004340)1.68700709
151Ependymoma (HP:0002888)1.68183513
152Nasal polyposis (HP:0100582)1.68024292
153Hypomagnesemia (HP:0002917)1.67614811
154Generalized aminoaciduria (HP:0002909)1.67059792
155Male pseudohermaphroditism (HP:0000037)1.66254181
156Colon cancer (HP:0003003)1.63799665
157Abnormal hair whorl (HP:0010721)1.62402522
158Hypoplasia of the uterus (HP:0000013)1.62311689
159Nephrogenic diabetes insipidus (HP:0009806)1.60994464
160Abnormality of renal resorption (HP:0011038)1.59361573
161Abnormality of midbrain morphology (HP:0002418)1.58802194
162Molar tooth sign on MRI (HP:0002419)1.58802194
163Glycosuria (HP:0003076)1.58696745
164Abnormality of urine glucose concentration (HP:0011016)1.58696745
165Abnormality of the anterior horn cell (HP:0006802)1.58268536
166Degeneration of anterior horn cells (HP:0002398)1.58268536
167Agitation (HP:0000713)1.56154513
168Megaloblastic anemia (HP:0001889)1.55594806
169Neoplasm of the adrenal gland (HP:0100631)1.54113879
170Hemiparesis (HP:0001269)1.54101611
171Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.52640846
172Hepatocellular necrosis (HP:0001404)1.51697311
173Sclerocornea (HP:0000647)1.50775189
174Epiphyseal stippling (HP:0010655)1.49593496
175Lissencephaly (HP:0001339)1.48470552
176Abnormality of the vitamin B12 metabolism (HP:0004341)1.48176918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.77184742
2PDK45.77184742
3STK393.92865733
4ERBB43.54226897
5PDK23.48631484
6TESK13.04303443
7EIF2AK12.73319638
8PBK2.65452009
9EPHB12.60233422
10LATS12.58649129
11BRSK22.55461937
12MET2.42943143
13STK162.41685589
14FRK2.34706737
15BCKDK2.31844231
16WNK32.18190493
17TSSK62.12161466
18MST1R2.10878350
19TRIM282.08155982
20NEK12.02380483
21TESK21.98021148
22BUB11.91227349
23ICK1.89014357
24PLK31.88216070
25CASK1.86347039
26VRK21.80679177
27GRK11.75301608
28MAP4K21.75015143
29WNK41.71326366
30ZAK1.67566515
31MKNK21.67389451
32WEE11.63968168
33AKT31.56591716
34PRKD31.55323419
35PLK21.53236520
36STK31.50011283
37FER1.43315158
38SRPK11.41820094
39EIF2AK31.40134319
40MAPKAPK51.38572293
41SIK11.35082883
42PKN11.34616169
43MAP3K41.32325253
44MAP3K121.30898341
45OXSR11.26842422
46CDC71.26279564
47DYRK21.26136780
48TNIK1.25419916
49FGFR41.24735263
50BRSK11.20888642
51STK38L1.14288277
52ABL21.14263828
53CSNK1G31.13325778
54MYLK1.12967401
55VRK11.12640932
56PTK2B1.11630245
57MKNK11.10552430
58MINK11.09982724
59BCR1.08730197
60DYRK1B1.04536151
61ADRBK21.03717098
62TAF11.03686259
63CSNK1G11.02994869
64ACVR1B1.02647150
65MAP3K31.00790968
66FGFR20.99351618
67TLK10.99087825
68MAP2K70.98766929
69EEF2K0.96667152
70CAMK1G0.93461934
71GSK3A0.93455971
72PRKCG0.91460864
73MAPK130.91160604
74TTK0.90359066
75TAOK30.90022825
76CSNK1G20.88852371
77PLK10.87130903
78EPHA20.86829192
79PRKCE0.83778637
80CAMK1D0.83528964
81SCYL20.82224059
82MARK10.81910950
83ERN10.80574190
84CSNK1A1L0.80265720
85ERBB30.74774022
86PAK30.74606660
87LIMK10.73871510
88PLK40.73560748
89PDK10.72580064
90MAP2K20.72125592
91MAPK40.72094724
92PHKG20.70808713
93PHKG10.70808713
94MST40.70256300
95PINK10.70132574
96PASK0.69175609
97NTRK10.69148451
98PRKCQ0.68510673
99PTK60.68137177
100MAP3K60.68046143
101STK100.67791932
102MUSK0.66395567
103NEK20.66120807
104MAPK110.65866226
105PNCK0.65781413
106EIF2AK20.65355962
107ILK0.65326098
108BMX0.61064497
109CSNK1E0.59824603
110NUAK10.59720081
111FGR0.59709393
112LMTK20.58255657
113INSRR0.58108737
114TYRO30.56804414
115CSNK1D0.55817071
116PRPF4B0.55709618
117PDPK10.55681285
118EPHA30.54780232
119DAPK10.54442427
120SGK20.53921990
121ERBB20.53194830
122BMPR1B0.52414725
123PRKCI0.51697618
124RPS6KB20.50683236
125LATS20.49913497
126CSNK1A10.47999631
127MAP3K90.47968059
128MAP2K40.47005111
129MAPK150.46827399
130CAMK2G0.45089378
131RET0.44690716
132PAK20.44669531
133FGFR10.44646618
134AURKA0.44427232
135ATR0.42500530
136CAMKK20.42464892
137CSF1R0.42213721
138IGF1R0.40637478
139MAP2K10.39650182
140NTRK30.39481049
141MAPKAPK30.38628574
142ABL10.38614117
143CDK60.37771797
144CSNK2A10.37609471
145ATM0.37502736
146SGK2230.36574408
147SGK4940.36574408
148ARAF0.36309807
149MELK0.35426937
150PRKACG0.34643657
151PTK20.34292070
152PRKCZ0.34128201
153DDR20.33887513
154CDK140.32795907
155KSR20.32525699
156EGFR0.32056090
157FLT30.31805746
158CDK150.29767978
159LRRK20.28332362
160TRIB30.27389177
161PIK3CG0.26460178
162PDGFRB0.26282464
163CLK10.25967155
164GRK60.25849113
165DAPK20.25779665
166WNK10.25350490
167PRKAA20.25154062
168MAP3K20.24737926
169TYK20.24214699

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.76834203
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.67038834
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.64741133
4Nitrogen metabolism_Homo sapiens_hsa009103.63465584
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88835588
6Fatty acid elongation_Homo sapiens_hsa000622.49442274
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47499709
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44782722
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.37278559
10Arginine biosynthesis_Homo sapiens_hsa002202.36673006
11Fatty acid degradation_Homo sapiens_hsa000712.28060397
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.25467475
13Complement and coagulation cascades_Homo sapiens_hsa046102.25365668
14Fatty acid metabolism_Homo sapiens_hsa012122.21771777
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16332024
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14141549
17Propanoate metabolism_Homo sapiens_hsa006402.13935014
18Tryptophan metabolism_Homo sapiens_hsa003802.06852099
19Chemical carcinogenesis_Homo sapiens_hsa052041.98569289
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98115915
21Pyruvate metabolism_Homo sapiens_hsa006201.97746816
22Butanoate metabolism_Homo sapiens_hsa006501.97366668
23Histidine metabolism_Homo sapiens_hsa003401.95781999
24Proteasome_Homo sapiens_hsa030501.94316919
25PPAR signaling pathway_Homo sapiens_hsa033201.94249632
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92524728
27Vitamin B6 metabolism_Homo sapiens_hsa007501.90807195
28Peroxisome_Homo sapiens_hsa041461.89969514
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75835464
30Sulfur metabolism_Homo sapiens_hsa009201.74723355
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.73549269
32Oxidative phosphorylation_Homo sapiens_hsa001901.68862939
33Selenocompound metabolism_Homo sapiens_hsa004501.67094665
34Fatty acid biosynthesis_Homo sapiens_hsa000611.61333101
35* Retinol metabolism_Homo sapiens_hsa008301.55570881
36Caffeine metabolism_Homo sapiens_hsa002321.49525587
37RNA polymerase_Homo sapiens_hsa030201.44340174
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41459328
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37002099
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.34137513
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33378494
42Mismatch repair_Homo sapiens_hsa034301.32661364
43Pentose phosphate pathway_Homo sapiens_hsa000301.30229796
44Biosynthesis of amino acids_Homo sapiens_hsa012301.30057607
45Fat digestion and absorption_Homo sapiens_hsa049751.28735097
46Staphylococcus aureus infection_Homo sapiens_hsa051501.28658343
47Parkinsons disease_Homo sapiens_hsa050121.28564217
48Bile secretion_Homo sapiens_hsa049761.26474285
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23506032
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.19809772
51beta-Alanine metabolism_Homo sapiens_hsa004101.19355261
52Carbon metabolism_Homo sapiens_hsa012001.18329813
53Glutathione metabolism_Homo sapiens_hsa004801.13964035
54Tyrosine metabolism_Homo sapiens_hsa003501.13461781
55Phenylalanine metabolism_Homo sapiens_hsa003601.12054938
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03736741
57ABC transporters_Homo sapiens_hsa020101.03513716
58Vitamin digestion and absorption_Homo sapiens_hsa049771.02938386
59Homologous recombination_Homo sapiens_hsa034401.00452308
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00137895
61Starch and sucrose metabolism_Homo sapiens_hsa005000.95765317
62Arginine and proline metabolism_Homo sapiens_hsa003300.94740248
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.88707737
64Basal transcription factors_Homo sapiens_hsa030220.87730904
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87494792
66Linoleic acid metabolism_Homo sapiens_hsa005910.84824501
67Collecting duct acid secretion_Homo sapiens_hsa049660.84823552
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82930985
69Alzheimers disease_Homo sapiens_hsa050100.82781211
70Huntingtons disease_Homo sapiens_hsa050160.82055491
71RNA degradation_Homo sapiens_hsa030180.81024590
72Phototransduction_Homo sapiens_hsa047440.77574043
73Glycerolipid metabolism_Homo sapiens_hsa005610.77502235
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76298702
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75808010
76Ether lipid metabolism_Homo sapiens_hsa005650.74083899
77Sulfur relay system_Homo sapiens_hsa041220.72938820
78Pyrimidine metabolism_Homo sapiens_hsa002400.72586181
79Non-homologous end-joining_Homo sapiens_hsa034500.68174007
80Nucleotide excision repair_Homo sapiens_hsa034200.67765010
81One carbon pool by folate_Homo sapiens_hsa006700.65682391
82Folate biosynthesis_Homo sapiens_hsa007900.65290719
83RNA transport_Homo sapiens_hsa030130.65094732
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64848549
85Nicotine addiction_Homo sapiens_hsa050330.64225162
86Base excision repair_Homo sapiens_hsa034100.63988906
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.63193533
88Purine metabolism_Homo sapiens_hsa002300.60758458
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60230494
90Fanconi anemia pathway_Homo sapiens_hsa034600.59726384
91DNA replication_Homo sapiens_hsa030300.58614582
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54624129
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52008762
94* Metabolic pathways_Homo sapiens_hsa011000.51982572
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51672229
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50776305
97Oocyte meiosis_Homo sapiens_hsa041140.48859944
98Serotonergic synapse_Homo sapiens_hsa047260.48276896
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43992809
100Spliceosome_Homo sapiens_hsa030400.42082344
101Vibrio cholerae infection_Homo sapiens_hsa051100.40973237
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.38656414
103Fructose and mannose metabolism_Homo sapiens_hsa000510.38531062
104Lysine degradation_Homo sapiens_hsa003100.33548123
105Sphingolipid metabolism_Homo sapiens_hsa006000.23877431
106Dorso-ventral axis formation_Homo sapiens_hsa043200.23589603
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20173419
108Ovarian steroidogenesis_Homo sapiens_hsa049130.15703429
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15193435
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.11070165
111Glucagon signaling pathway_Homo sapiens_hsa049220.10996171
112Prion diseases_Homo sapiens_hsa050200.09088709
113Protein export_Homo sapiens_hsa030600.06960709
114Systemic lupus erythematosus_Homo sapiens_hsa053220.06338463
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06123135
116Arachidonic acid metabolism_Homo sapiens_hsa005900.01171510
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.2094298
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2076023
119Protein digestion and absorption_Homo sapiens_hsa04974-0.2011669
120Legionellosis_Homo sapiens_hsa05134-0.1985225
121Hepatitis C_Homo sapiens_hsa05160-0.1977489
122Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1840187
123Phagosome_Homo sapiens_hsa04145-0.1525742
124Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1351338
125Malaria_Homo sapiens_hsa05144-0.1151281
126N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1067472
127Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1035446
128Insulin resistance_Homo sapiens_hsa04931-0.0890136
129Galactose metabolism_Homo sapiens_hsa00052-0.0884593
130Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0632853
131AMPK signaling pathway_Homo sapiens_hsa04152-0.0468206
132Mineral absorption_Homo sapiens_hsa04978-0.0291522

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