RCN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.65310380
2behavioral response to nicotine (GO:0035095)3.98678786
3layer formation in cerebral cortex (GO:0021819)3.85593669
4negative regulation of astrocyte differentiation (GO:0048712)3.72121099
5dermatan sulfate biosynthetic process (GO:0030208)3.70763611
6dermatan sulfate metabolic process (GO:0030205)3.68764113
7nucleobase catabolic process (GO:0046113)3.58241496
8regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.55914807
9cellular potassium ion homeostasis (GO:0030007)3.52761944
10nonmotile primary cilium assembly (GO:0035058)3.44674057
11negative regulation of oligodendrocyte differentiation (GO:0048715)3.43648631
12axonal fasciculation (GO:0007413)3.42313430
13neuron cell-cell adhesion (GO:0007158)3.42013896
14neuron recognition (GO:0008038)3.37386121
15cell communication by electrical coupling (GO:0010644)3.35896780
16positive regulation of mitochondrial fission (GO:0090141)3.32650049
17presynaptic membrane assembly (GO:0097105)3.28169850
18sequestering of extracellular ligand from receptor (GO:0035581)3.26306480
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.21764009
20response to auditory stimulus (GO:0010996)3.21752938
21locomotory exploration behavior (GO:0035641)3.18001558
22neuronal stem cell maintenance (GO:0097150)3.17182200
23sodium ion export (GO:0071436)3.17068308
24synaptic vesicle exocytosis (GO:0016079)3.16683272
25retinal ganglion cell axon guidance (GO:0031290)3.15162497
26negative regulation of sodium ion transport (GO:0010766)3.11916232
27intraciliary transport (GO:0042073)3.07868723
28DNA damage response, detection of DNA damage (GO:0042769)3.06842832
29chondroitin sulfate catabolic process (GO:0030207)3.04344974
30presynaptic membrane organization (GO:0097090)3.02521547
31vocalization behavior (GO:0071625)3.01276009
32limb bud formation (GO:0060174)2.98739540
33paraxial mesoderm development (GO:0048339)2.98314495
34calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.98178085
35regulation of respiratory system process (GO:0044065)2.97590275
36synaptic vesicle maturation (GO:0016188)2.97249749
37olfactory bulb development (GO:0021772)2.96760214
38chondrocyte proliferation (GO:0035988)2.96275636
39negative regulation of glial cell differentiation (GO:0045686)2.93284366
40forebrain neuron differentiation (GO:0021879)2.90122727
41glutamate secretion (GO:0014047)2.88848700
42regulation of astrocyte differentiation (GO:0048710)2.88812584
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.88344294
44positive regulation of synapse assembly (GO:0051965)2.84002742
45cellular sodium ion homeostasis (GO:0006883)2.80882310
46sequestering of actin monomers (GO:0042989)2.79203979
47G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.79028824
48lens fiber cell development (GO:0070307)2.76916013
49dendritic spine morphogenesis (GO:0060997)2.76430474
50gamma-aminobutyric acid transport (GO:0015812)2.76399322
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.76259005
52exploration behavior (GO:0035640)2.74550320
53neurotransmitter uptake (GO:0001504)2.73265444
54atrial cardiac muscle cell action potential (GO:0086014)2.73239307
55innervation (GO:0060384)2.72555441
56cerebral cortex radially oriented cell migration (GO:0021799)2.71215048
57regulation of synapse structural plasticity (GO:0051823)2.69886542
58negative regulation of smoothened signaling pathway (GO:0045879)2.69662179
59epithelial cilium movement (GO:0003351)2.69332943
60establishment of mitochondrion localization (GO:0051654)2.69227078
61neural tube formation (GO:0001841)2.68759452
62regulation of development, heterochronic (GO:0040034)2.67477810
63glial cell proliferation (GO:0014009)2.66212321
64ionotropic glutamate receptor signaling pathway (GO:0035235)2.65790245
65postsynaptic membrane organization (GO:0001941)2.64752558
66protein localization to cilium (GO:0061512)2.64392580
67auditory behavior (GO:0031223)2.64180227
68somite development (GO:0061053)2.64179083
69neuronal action potential propagation (GO:0019227)2.63113556
70regulation of timing of cell differentiation (GO:0048505)2.62698973
71spinal cord association neuron differentiation (GO:0021527)2.62327401
72endocardial cushion morphogenesis (GO:0003203)2.62269091
73regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61749864
74synapse assembly (GO:0007416)2.61629497
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60340864
76lateral sprouting from an epithelium (GO:0060601)2.59638730
77chromatin remodeling at centromere (GO:0031055)2.59514475
78protein localization to synapse (GO:0035418)2.59210145
79cerebral cortex neuron differentiation (GO:0021895)2.58982954
80glutamate receptor signaling pathway (GO:0007215)2.58708884
81regulation of respiratory gaseous exchange (GO:0043576)2.57853178
82negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57448926
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57367075
84regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.56984494
85transmission of nerve impulse (GO:0019226)2.56277022
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55423451
87central nervous system myelination (GO:0022010)2.54876256
88axon ensheathment in central nervous system (GO:0032291)2.54876256
89response to gravity (GO:0009629)2.54638335
90dendrite morphogenesis (GO:0048813)2.53351266
91regulation of vesicle fusion (GO:0031338)2.53311668
92amino acid import (GO:0043090)2.51843326
93regulation of synaptic vesicle exocytosis (GO:2000300)2.51675637
94L-serine transport (GO:0015825)2.51072657
95regulation of glutamate receptor signaling pathway (GO:1900449)2.51022595
96neurotransmitter secretion (GO:0007269)2.49942662
97negative regulation of catenin import into nucleus (GO:0035414)2.49732146
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49269207
99neuroblast proliferation (GO:0007405)2.49064857
100negative regulation of axon guidance (GO:1902668)2.49063707
101cilium morphogenesis (GO:0060271)2.45931518
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45316856
103startle response (GO:0001964)2.43250132
104protein polyglutamylation (GO:0018095)2.42989676
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.42323613
106regulation of synapse assembly (GO:0051963)2.42299188
107C4-dicarboxylate transport (GO:0015740)2.40650176
108regulation of neuronal synaptic plasticity (GO:0048168)2.40483223
109cilium assembly (GO:0042384)2.40177313
110central nervous system projection neuron axonogenesis (GO:0021952)2.40069883
111CENP-A containing nucleosome assembly (GO:0034080)2.39987345
112cilium organization (GO:0044782)2.38845687
113positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.38633340
114mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.38633340
115hippocampus development (GO:0021766)2.38342126
116regulation of synaptic transmission, glutamatergic (GO:0051966)2.38272249
117L-amino acid import (GO:0043092)2.37746098
118gamma-aminobutyric acid signaling pathway (GO:0007214)2.37680112
119potassium ion homeostasis (GO:0055075)2.36579641
120synaptic transmission, glutamatergic (GO:0035249)2.36161871
121ganglion development (GO:0061548)2.35014645
122regulation of posttranscriptional gene silencing (GO:0060147)2.34721053
123regulation of gene silencing by miRNA (GO:0060964)2.34721053
124regulation of gene silencing by RNA (GO:0060966)2.34721053
125negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.34147983
126cell proliferation in forebrain (GO:0021846)2.33381921
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32038257
128extracellular fibril organization (GO:0043206)2.31969897
129mesenchyme morphogenesis (GO:0072132)2.31712038
130regulation of collateral sprouting (GO:0048670)2.31674773
131DNA double-strand break processing (GO:0000729)2.31311427
132organelle disassembly (GO:1903008)2.31167581
133kidney morphogenesis (GO:0060993)2.31083668
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.30031932
135head development (GO:0060322)2.29899280
136cochlea morphogenesis (GO:0090103)2.29655398
137spinal cord development (GO:0021510)2.29160199
138alanine transport (GO:0032328)2.28754194
139neuron projection extension involved in neuron projection guidance (GO:1902284)2.27034162
140axon extension involved in axon guidance (GO:0048846)2.27034162
141epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.26984728
142cellular response to cholesterol (GO:0071397)2.26349119
143long-term synaptic potentiation (GO:0060291)2.26012543
144regulation of mesenchymal cell apoptotic process (GO:2001053)2.25690383
145regulation of synaptic vesicle transport (GO:1902803)2.24791103
146cardiac left ventricle morphogenesis (GO:0003214)2.24474347
147negative regulation of cytosolic calcium ion concentration (GO:0051481)2.24440398
148hindbrain development (GO:0030902)2.24337117
149cell differentiation in spinal cord (GO:0021515)2.24236753
150outer ear morphogenesis (GO:0042473)2.23888528
151microtubule depolymerization (GO:0007019)2.23468258
152cilium movement (GO:0003341)2.21343075
153L-serine metabolic process (GO:0006563)2.20969052
154appendage development (GO:0048736)2.20139334
155limb development (GO:0060173)2.20139334
156cell migration in hindbrain (GO:0021535)2.17058949
157positive regulation of dendritic spine morphogenesis (GO:0061003)2.16381907
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.15936838
159smoothened signaling pathway (GO:0007224)2.14816920
160neuron migration (GO:0001764)2.13641078
161regulation of oligodendrocyte differentiation (GO:0048713)2.13363390
162cholesterol biosynthetic process (GO:0006695)2.12913032
163cornea development in camera-type eye (GO:0061303)2.12384285
164cullin deneddylation (GO:0010388)2.12137816
165regulation of mitochondrial fission (GO:0090140)2.11221393
166pyrimidine dimer repair (GO:0006290)2.10113915
167ribonucleoprotein complex disassembly (GO:0032988)2.09201953
168sympathetic nervous system development (GO:0048485)2.08375202
169neurotransmitter-gated ion channel clustering (GO:0072578)2.07340848
170neuron fate commitment (GO:0048663)2.07255423
171ephrin receptor signaling pathway (GO:0048013)2.07154855
172DNA replication-independent nucleosome organization (GO:0034724)2.06731945
173DNA replication-independent nucleosome assembly (GO:0006336)2.06731945
174dorsal/ventral pattern formation (GO:0009953)2.05942987
175establishment of tissue polarity (GO:0007164)2.05700828
176establishment of planar polarity (GO:0001736)2.05700828
177short-term memory (GO:0007614)2.03970429
178homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.03405175
179cell fate commitment involved in formation of primary germ layer (GO:0060795)2.02966593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37789795
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.31890840
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27484549
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16106477
5EED_16625203_ChIP-ChIP_MESCs_Mouse3.14698016
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.11863215
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse3.02558641
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.97893784
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91976554
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91976554
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.86042973
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.84408625
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.83872567
14GBX2_23144817_ChIP-Seq_PC3_Human2.75523132
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44912434
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.43176142
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.42421637
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.37962184
19AR_21572438_ChIP-Seq_LNCaP_Human2.23091182
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21012616
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.20435159
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.19010291
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14551020
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12784358
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.10329927
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03530501
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95456708
28ZNF274_21170338_ChIP-Seq_K562_Hela1.83852749
29VDR_22108803_ChIP-Seq_LS180_Human1.79187372
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77628326
31IRF1_19129219_ChIP-ChIP_H3396_Human1.77573176
32IGF1R_20145208_ChIP-Seq_DFB_Human1.73110695
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.71969084
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71768013
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70407867
36REST_21632747_ChIP-Seq_MESCs_Mouse1.69411580
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68130857
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.67989290
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66233229
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.65171259
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63961210
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63572307
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59367824
44MYC_18940864_ChIP-ChIP_HL60_Human1.58207438
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57941095
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57751615
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57410224
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.56743992
49P300_19829295_ChIP-Seq_ESCs_Human1.55777821
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.54260406
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51642040
52* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51339757
53FUS_26573619_Chip-Seq_HEK293_Human1.50379955
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45729588
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.43970099
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43317187
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42315446
58TP53_18474530_ChIP-ChIP_U2OS_Human1.42164988
59DROSHA_22980978_ChIP-Seq_HELA_Human1.42029916
60ELK1_19687146_ChIP-ChIP_HELA_Human1.39234777
61RNF2_27304074_Chip-Seq_NSC_Mouse1.38790447
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.37767382
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36330877
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33424089
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.32287721
66SMAD4_21799915_ChIP-Seq_A2780_Human1.32196280
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31783477
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.31517793
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30409341
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29175527
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28677419
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25983494
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.25616363
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25582065
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25448393
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25237891
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.23342897
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22870892
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22303341
80AR_25329375_ChIP-Seq_VCAP_Human1.21776329
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21539390
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21084119
83E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20671463
84EWS_26573619_Chip-Seq_HEK293_Human1.19907430
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.19429074
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.16589445
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15461568
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14731643
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14637154
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13489643
91BCAT_22108803_ChIP-Seq_LS180_Human1.12499392
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12104236
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12072686
94TAF15_26573619_Chip-Seq_HEK293_Human1.11749936
95* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11652073
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10934962
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.10823915
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10431963
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09171707
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08070363
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08070363
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.07382766
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.07173343
104MYC_18555785_ChIP-Seq_MESCs_Mouse1.06463317
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.04549784
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04353061
107SOX9_26525672_Chip-Seq_HEART_Mouse1.04076812
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03817372
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03683868
110CBP_20019798_ChIP-Seq_JUKART_Human1.03683868
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03504327
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03362465
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03260384
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02011235
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01045651
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00729000
117POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00434446
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.99787788
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98608901
120JUN_21703547_ChIP-Seq_K562_Human0.98431327
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.97814787
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97249197
123* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96671404
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96266685
125ETS1_20019798_ChIP-Seq_JURKAT_Human0.96109542
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96096838
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96018536
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95784942
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95555632
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95399777
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95096083
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93976139
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93976139
134RXR_22108803_ChIP-Seq_LS180_Human0.93493097
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92952379
136* AR_19668381_ChIP-Seq_PC3_Human0.92571228
137* RUNX2_22187159_ChIP-Seq_PCA_Human0.92434104
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91407955
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90103099
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89826772
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89423239
142ER_23166858_ChIP-Seq_MCF-7_Human0.89142508
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88970452
144TP53_16413492_ChIP-PET_HCT116_Human0.87961755
145LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82162508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.01318154
2MP0003880_abnormal_central_pattern2.93959848
3MP0009384_cardiac_valve_regurgitation2.55326548
4MP0003122_maternal_imprinting2.51497795
5MP0008789_abnormal_olfactory_epithelium2.36660217
6MP0004858_abnormal_nervous_system2.31830954
7MP0003635_abnormal_synaptic_transmissio2.31377278
8MP0003279_aneurysm2.30878791
9MP0005423_abnormal_somatic_nervous2.30444076
10MP0002653_abnormal_ependyma_morphology2.30189814
11MP0005499_abnormal_olfactory_system2.25355090
12MP0005394_taste/olfaction_phenotype2.25355090
13MP0009780_abnormal_chondrocyte_physiolo2.21325810
14MP0004133_heterotaxia2.17000847
15MP0003890_abnormal_embryonic-extraembry2.11359801
16MP0000049_abnormal_middle_ear2.03287869
17MP0004270_analgesia2.02796127
18MP0003136_yellow_coat_color2.02646325
19MP0006276_abnormal_autonomic_nervous1.93332057
20MP0005623_abnormal_meninges_morphology1.91011712
21MP0000778_abnormal_nervous_system1.89969843
22MP0002102_abnormal_ear_morphology1.89715716
23MP0001293_anophthalmia1.87448000
24MP0005503_abnormal_tendon_morphology1.86150859
25MP0002063_abnormal_learning/memory/cond1.82735942
26MP0009745_abnormal_behavioral_response1.80185856
27MP0001299_abnormal_eye_distance/1.79897242
28MP0001486_abnormal_startle_reflex1.73073955
29MP0002064_seizures1.71996886
30MP0008438_abnormal_cutaneous_collagen1.70800688
31MP0002734_abnormal_mechanical_nocicepti1.70723537
32MP0009250_abnormal_appendicular_skeleto1.70584791
33MP0000566_synostosis1.70452664
34MP0004885_abnormal_endolymph1.69403055
35MP0009046_muscle_twitch1.68395565
36MP0010030_abnormal_orbit_morphology1.67844707
37MP0002234_abnormal_pharynx_morphology1.66649967
38MP0002572_abnormal_emotion/affect_behav1.66214118
39MP0005645_abnormal_hypothalamus_physiol1.62736358
40MP0001958_emphysema1.58591671
41MP0002751_abnormal_autonomic_nervous1.57398019
42MP0003385_abnormal_body_wall1.51627752
43MP0003942_abnormal_urinary_system1.51010490
44MP0003119_abnormal_digestive_system1.50396300
45MP0005646_abnormal_pituitary_gland1.48658875
46MP0002638_abnormal_pupillary_reflex1.46725602
47MP0001968_abnormal_touch/_nociception1.46279882
48MP0004272_abnormal_basement_membrane1.46064204
49MP0003567_abnormal_fetal_cardiomyocyte1.43526715
50MP0008877_abnormal_DNA_methylation1.42340747
51MP0002557_abnormal_social/conspecific_i1.40803132
52MP0003329_amyloid_beta_deposits1.40250707
53MP0001440_abnormal_grooming_behavior1.39442350
54MP0005253_abnormal_eye_physiology1.38175722
55MP0003787_abnormal_imprinting1.34301194
56MP0001286_abnormal_eye_development1.33426060
57MP0005187_abnormal_penis_morphology1.32573514
58MP0002733_abnormal_thermal_nociception1.32261300
59MP0003283_abnormal_digestive_organ1.31672981
60MP0002697_abnormal_eye_size1.29685285
61MP0002184_abnormal_innervation1.27936139
62MP0002272_abnormal_nervous_system1.26286675
63MP0002909_abnormal_adrenal_gland1.25634188
64MP0000631_abnormal_neuroendocrine_gland1.24475899
65MP0003123_paternal_imprinting1.24120550
66MP0002282_abnormal_trachea_morphology1.23804263
67MP0003938_abnormal_ear_development1.22886078
68MP0002752_abnormal_somatic_nervous1.22517773
69MP0002736_abnormal_nociception_after1.21494643
70MP0000428_abnormal_craniofacial_morphol1.20605362
71MP0000537_abnormal_urethra_morphology1.19226015
72MP0002067_abnormal_sensory_capabilities1.19062959
73MP0003121_genomic_imprinting1.18888252
74MP0000013_abnormal_adipose_tissue1.18462489
75MP0001970_abnormal_pain_threshold1.17318317
76MP0000955_abnormal_spinal_cord1.16298785
77MP0001905_abnormal_dopamine_level1.16169485
78MP0000534_abnormal_ureter_morphology1.15999333
79MP0001188_hyperpigmentation1.15358831
80MP0002822_catalepsy1.14786135
81MP0005391_vision/eye_phenotype1.13865840
82MP0010386_abnormal_urinary_bladder1.13323330
83MP0001502_abnormal_circadian_rhythm1.11505215
84MP0003634_abnormal_glial_cell1.11218222
85MP0000647_abnormal_sebaceous_gland1.11091187
86MP0008932_abnormal_embryonic_tissue1.10948026
87MP0005551_abnormal_eye_electrophysiolog1.10565020
88MP0005508_abnormal_skeleton_morphology1.10229502
89MP0002249_abnormal_larynx_morphology1.09861151
90MP0002089_abnormal_postnatal_growth/wei1.09200237
91MP0001501_abnormal_sleep_pattern1.09145916
92MP0005171_absent_coat_pigmentation1.08117684
93MP0003755_abnormal_palate_morphology1.07970845
94MP0002882_abnormal_neuron_morphology1.07627175
95MP0002116_abnormal_craniofacial_bone1.07485667
96MP0006072_abnormal_retinal_apoptosis1.07466758
97MP0005257_abnormal_intraocular_pressure1.06671238
98MP0004134_abnormal_chest_morphology1.05173570
99MP0002152_abnormal_brain_morphology1.04324053
100MP0001485_abnormal_pinna_reflex1.03801639
101MP0004142_abnormal_muscle_tone1.03472362
102MP0003315_abnormal_perineum_morphology1.03336137
103MP0001270_distended_abdomen1.02649975
104MP0002735_abnormal_chemical_nociception1.02403874
105MP0004233_abnormal_muscle_weight1.01753560
106MP0005195_abnormal_posterior_eye1.01443866
107MP0000026_abnormal_inner_ear1.00759153
108MP0002295_abnormal_pulmonary_circulatio0.99422697
109MP0001529_abnormal_vocalization0.99343061
110MP0000163_abnormal_cartilage_morphology0.98198496
111MP0002938_white_spotting0.98176307
112MP0002160_abnormal_reproductive_system0.97535669
113MP0005248_abnormal_Harderian_gland0.96986963
114MP0002932_abnormal_joint_morphology0.96101919
115MP0003937_abnormal_limbs/digits/tail_de0.95972317
116MP0008569_lethality_at_weaning0.93824752
117MP0005386_behavior/neurological_phenoty0.91841923
118MP0004924_abnormal_behavior0.91841923
119MP0006292_abnormal_olfactory_placode0.91654089
120MP0002092_abnormal_eye_morphology0.91331722
121MP0001984_abnormal_olfaction0.91042589
122MP0003693_abnormal_embryo_hatching0.90791117
123MP0002177_abnormal_outer_ear0.89761244
124MP0008058_abnormal_DNA_repair0.89365802
125MP0003861_abnormal_nervous_system0.88648181
126MP0008995_early_reproductive_senescence0.88236224
127MP0002084_abnormal_developmental_patter0.86784076
128MP0001664_abnormal_digestion0.86045296
129MP0005275_abnormal_skin_tensile0.85933915
130MP0003011_delayed_dark_adaptation0.85488705
131MP0000751_myopathy0.83885614
132MP0004811_abnormal_neuron_physiology0.83698663
133MP0002111_abnormal_tail_morphology0.83266744
134MP0002066_abnormal_motor_capabilities/c0.82734088
135MP0000569_abnormal_digit_pigmentation0.82135037
136MP0003137_abnormal_impulse_conducting0.81742967
137MP0004742_abnormal_vestibular_system0.81450561
138MP0002081_perinatal_lethality0.81274341
139MP0002233_abnormal_nose_morphology0.79966833
140MP0001943_abnormal_respiration0.79952796
141MP0001177_atelectasis0.79807695
142MP0002090_abnormal_vision0.79520279
143MP0004197_abnormal_fetal_growth/weight/0.78982175
144MP0003935_abnormal_craniofacial_develop0.78894688
145MP0003115_abnormal_respiratory_system0.78654883
146MP0001963_abnormal_hearing_physiology0.75986968

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the phalanges of the hand (HP:0009802)3.98473019
2Aplasia involving bones of the extremities (HP:0009825)3.98473019
3Aplasia involving bones of the upper limbs (HP:0009823)3.98473019
4Megalencephaly (HP:0001355)3.88152931
5True hermaphroditism (HP:0010459)3.24293680
6Protrusio acetabuli (HP:0003179)3.10847981
7Gait imbalance (HP:0002141)3.07970285
8Pancreatic cysts (HP:0001737)3.03896276
9Medial flaring of the eyebrow (HP:0010747)2.99238446
10Congenital primary aphakia (HP:0007707)2.96435835
11Abnormality of midbrain morphology (HP:0002418)2.92506160
12Molar tooth sign on MRI (HP:0002419)2.92506160
13Cortical dysplasia (HP:0002539)2.86554670
14Abnormality of dentin (HP:0010299)2.82783748
15Morphological abnormality of the middle ear (HP:0008609)2.82761119
16Neonatal short-limb short stature (HP:0008921)2.79198522
17Nephronophthisis (HP:0000090)2.76687491
18Vascular tortuosity (HP:0004948)2.76403877
19Nephrogenic diabetes insipidus (HP:0009806)2.68866699
20Hemiparesis (HP:0001269)2.68807520
21Focal motor seizures (HP:0011153)2.66769339
22Vaginal atresia (HP:0000148)2.66073911
23Genital tract atresia (HP:0001827)2.61881017
24Arterial tortuosity (HP:0005116)2.60132766
25Diplopia (HP:0000651)2.59199387
26Abnormality of binocular vision (HP:0011514)2.59199387
27Anophthalmia (HP:0000528)2.55525420
28Coronal craniosynostosis (HP:0004440)2.53769910
29Humeroradial synostosis (HP:0003041)2.52658854
30Synostosis involving the elbow (HP:0003938)2.52658854
31Abnormality of the labia minora (HP:0012880)2.44877960
32Abnormality of the middle phalanges of the toes (HP:0010183)2.44542594
33Fibular aplasia (HP:0002990)2.44539501
34Hyperglycinemia (HP:0002154)2.38881703
35Septo-optic dysplasia (HP:0100842)2.38722001
36Colon cancer (HP:0003003)2.31300637
37Shallow orbits (HP:0000586)2.29372034
38Sclerocornea (HP:0000647)2.29291530
39Postaxial foot polydactyly (HP:0001830)2.28005099
40Postaxial hand polydactyly (HP:0001162)2.27111110
41Abnormality of the renal medulla (HP:0100957)2.26384848
42Anencephaly (HP:0002323)2.24492298
43Premature rupture of membranes (HP:0001788)2.24211965
44Bronchomalacia (HP:0002780)2.21549188
45Epileptic encephalopathy (HP:0200134)2.20002654
46Specific learning disability (HP:0001328)2.19089994
47Oligodactyly (hands) (HP:0001180)2.18761943
48Broad foot (HP:0001769)2.16290928
49Occipital encephalocele (HP:0002085)2.15391382
50Preaxial hand polydactyly (HP:0001177)2.14913412
51Visual hallucinations (HP:0002367)2.14756187
52Optic nerve hypoplasia (HP:0000609)2.13789865
53Rib fusion (HP:0000902)2.13648968
54Poor coordination (HP:0002370)2.12790360
55Short middle phalanx of the 5th finger (HP:0004220)2.11067118
56Clumsiness (HP:0002312)2.09125868
57Patellar aplasia (HP:0006443)2.07055905
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.06800585
59Microglossia (HP:0000171)2.06545313
60Neurofibrillary tangles (HP:0002185)2.06018755
61Narrow nasal bridge (HP:0000446)2.04137845
62Pendular nystagmus (HP:0012043)2.03773553
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.02745131
64Mixed hearing impairment (HP:0000410)2.02590108
65Chronic hepatic failure (HP:0100626)2.02080568
66Soft skin (HP:0000977)2.00924291
67Facial shape deformation (HP:0011334)2.00641466
68Potter facies (HP:0002009)2.00641466
69Bladder diverticulum (HP:0000015)2.00168350
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99816463
71Limb dystonia (HP:0002451)1.99571361
72Hemiplegia (HP:0002301)1.98451334
73Supernumerary spleens (HP:0009799)1.98139455
74Aplasia/Hypoplasia of the patella (HP:0006498)1.97616317
75Short tibia (HP:0005736)1.97056132
76Cystic liver disease (HP:0006706)1.96340253
77Aplasia/Hypoplasia of the fibula (HP:0006492)1.96330801
78Short hallux (HP:0010109)1.94716806
79Hypoventilation (HP:0002791)1.92994999
80Broad ribs (HP:0000885)1.92151708
81Hepatoblastoma (HP:0002884)1.91562993
82Supranuclear gaze palsy (HP:0000605)1.90895364
83Focal seizures (HP:0007359)1.90564799
84Intestinal atresia (HP:0011100)1.90320713
85Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.90098020
86Biconcave vertebral bodies (HP:0004586)1.88775323
87Long nose (HP:0003189)1.88346602
88Hemivertebrae (HP:0002937)1.87801106
89Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.85581295
90Overgrowth (HP:0001548)1.85497165
91Bilateral microphthalmos (HP:0007633)1.83627508
92Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.82902180
93Broad long bones (HP:0005622)1.82454425
94Broad metatarsal (HP:0001783)1.82055764
95Micropenis (HP:0000054)1.81468411
96Esophageal atresia (HP:0002032)1.80929947
97Hyperglycinuria (HP:0003108)1.80469404
98Aortic dissection (HP:0002647)1.80231627
99Oligodactyly (HP:0012165)1.80071365
100Abnormality of the phalanges of the 5th finger (HP:0004213)1.79544690
101Polyphagia (HP:0002591)1.79478672
102Dandy-Walker malformation (HP:0001305)1.79286714
103Aortic aneurysm (HP:0004942)1.78472157
104Aplasia/Hypoplasia of the hallux (HP:0008362)1.78322003
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77805021
106Short 4th metacarpal (HP:0010044)1.77805021
107Abolished electroretinogram (ERG) (HP:0000550)1.76397253
108Decreased testicular size (HP:0008734)1.76355106
109Infantile muscular hypotonia (HP:0008947)1.76272016
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.75931224
111Progressive cerebellar ataxia (HP:0002073)1.75626049
112Abnormality of glycine metabolism (HP:0010895)1.74527318
113Abnormality of serine family amino acid metabolism (HP:0010894)1.74527318
114Narrow forehead (HP:0000341)1.73056983
115Cerebral inclusion bodies (HP:0100314)1.72155689
116Bifid tongue (HP:0010297)1.71826804
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71567867
118Abnormality of alanine metabolism (HP:0010916)1.71567867
119Hyperalaninemia (HP:0003348)1.71567867
120Tracheomalacia (HP:0002779)1.71492861
121Retinal dysplasia (HP:0007973)1.71351211
122Vitreoretinal degeneration (HP:0000655)1.71285221
123Broad face (HP:0000283)1.71257553
124Renal hypoplasia (HP:0000089)1.71096866
125Aganglionic megacolon (HP:0002251)1.68844631
126Buphthalmos (HP:0000557)1.68665538
127Broad toe (HP:0001837)1.67280872
128Agitation (HP:0000713)1.67018436
129Abnormal lung lobation (HP:0002101)1.66797980
130Pancreatic fibrosis (HP:0100732)1.66448037
131Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65568812
132Lissencephaly (HP:0001339)1.64560485
133Cerebellar dysplasia (HP:0007033)1.64366045
134Triphalangeal thumb (HP:0001199)1.63999301
135Split foot (HP:0001839)1.63469562
136Bile duct proliferation (HP:0001408)1.63007022
137Abnormal biliary tract physiology (HP:0012439)1.63007022
138Labial hypoplasia (HP:0000066)1.63002820
139Chorioretinal atrophy (HP:0000533)1.62435222
140Hypoplasia of the brainstem (HP:0002365)1.62425257
141Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62425257
142Papilledema (HP:0001085)1.62231962
143Deviation of the hallux (HP:0010051)1.62101376
144Stenosis of the external auditory canal (HP:0000402)1.61981907
145Cutaneous syndactyly (HP:0012725)1.61943896
146Pachygyria (HP:0001302)1.61392284
147Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61356939
148Congenital glaucoma (HP:0001087)1.61143499
149Hypoplastic left heart (HP:0004383)1.60998154
150Abnormal respiratory motile cilium morphology (HP:0005938)1.60860531
151Abnormal respiratory epithelium morphology (HP:0012253)1.60860531
152Preaxial foot polydactyly (HP:0001841)1.60462775
153Scrotal hypoplasia (HP:0000046)1.59815963
154Gastrointestinal atresia (HP:0002589)1.59761003
155Broad distal phalanx of finger (HP:0009836)1.59081837
156Excessive salivation (HP:0003781)1.59036852
157Drooling (HP:0002307)1.59036852
158Generalized tonic-clonic seizures (HP:0002069)1.58623862
159Meckel diverticulum (HP:0002245)1.58002583
160Truncal ataxia (HP:0002078)1.57909695
161Symphalangism affecting the phalanges of the hand (HP:0009773)1.57887923
162Absent septum pellucidum (HP:0001331)1.56875249
163Chorioretinal coloboma (HP:0000567)1.56739772
164Myokymia (HP:0002411)1.56593420
165Bowel diverticulosis (HP:0005222)1.56515982
166Renal duplication (HP:0000075)1.56452481
167Renal dysplasia (HP:0000110)1.56014883
168Abnormality of the proximal phalanges of the hand (HP:0009834)1.55103077
169Shoulder girdle muscle weakness (HP:0003547)1.54917284
170Hypoplastic pelvis (HP:0008839)1.54820876
171Thyroid-stimulating hormone excess (HP:0002925)1.54514446
172Myelomeningocele (HP:0002475)1.53850632
173Broad phalanx (HP:0006009)1.53402118
174Short foot (HP:0001773)1.53236599
175Type II lissencephaly (HP:0007260)1.52904721
176Epiphyseal dysplasia (HP:0002656)1.52846153
177Absent hair (HP:0002298)1.51536227
178Abnormal eating behavior (HP:0100738)1.50987355
179Cutaneous finger syndactyly (HP:0010554)1.50888655
180Broad-based gait (HP:0002136)1.50737875
181Spinal cord compression (HP:0002176)1.50438308
182Aplasia/Hypoplasia of the clavicles (HP:0006710)1.50265088
183Abnormality of the axillary hair (HP:0100134)1.49454097
184Abnormality of secondary sexual hair (HP:0009888)1.49454097
185Mesomelia (HP:0003027)1.49271988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.33776123
2NTRK33.20399457
3NTRK23.13478862
4MARK12.82640187
5SRPK12.50863900
6DDR22.48560985
7TRIM282.47966717
8MINK12.40348138
9LMTK22.30898983
10CASK2.26885075
11PAK32.15759837
12MAP3K92.12808856
13LATS22.11861555
14MAP3K42.11762003
15MAP2K72.08151911
16PHKG22.03273220
17PHKG12.03273220
18MAP3K121.98159083
19TNIK1.97142304
20SCYL21.92958958
21MAPK131.91203096
22KSR11.88229365
23PRKD31.87809493
24LIMK11.75437571
25CDK191.72670988
26ERBB31.71595873
27EPHB21.66699659
28MAP4K21.65511723
29PLK21.61464698
30CSNK1A1L1.61226150
31CDC71.61213297
32PINK11.56732685
33UHMK11.56322018
34RPS6KA41.53238053
35PAK61.47497178
36BCKDK1.41540850
37WEE11.38960106
38PDGFRA1.36453389
39NTRK11.33534632
40MUSK1.32766589
41ADRBK21.25101826
42ZAK1.20085140
43CDK141.19649341
44PNCK1.18914453
45EPHA31.16639738
46CDK51.15851062
47PLK41.13286543
48FER1.13279775
49STK38L1.13168500
50BCR1.10558054
51TSSK61.09523323
52CDK181.06960995
53TRIB31.05818825
54MOS1.04975049
55CDK151.02211234
56DYRK1B1.00504476
57ROCK11.00000166
58CAMKK20.99280639
59KSR20.98966167
60PRKCG0.98314267
61VRK10.97693460
62DYRK1A0.96004282
63BMPR1B0.95896488
64INSRR0.95729248
65CDK11A0.94999774
66TAF10.94801816
67ROCK20.93850287
68NEK10.93762868
69WNK40.91309862
70FGFR10.90705129
71GRK10.90123612
72NUAK10.89830759
73CAMK2A0.88137219
74SIK30.88128743
75CSNK1G20.86869963
76PLK10.86194008
77NEK20.85826707
78SIK20.84428768
79CAMKK10.83849725
80DYRK20.82740949
81PRKCE0.82433333
82CDK80.81472101
83TTK0.81189295
84ADRBK10.81087928
85MAP2K40.79616799
86ARAF0.77217977
87FGFR20.73431811
88TYRO30.73007999
89WNK30.71336799
90TESK10.70959946
91BUB10.70816752
92PAK20.69355242
93MAPK150.69327089
94CDC42BPA0.66684713
95MKNK10.66540104
96STK160.62860024
97FRK0.62635875
98STK390.62457579
99ATR0.62433635
100SIK10.62269256
101VRK20.62169798
102CSNK1G30.59711574
103DMPK0.59273049
104CAMK2B0.58656263
105PBK0.57298731
106BRSK20.57208749
107CHEK20.54780377
108PTK20.53611684
109BRD40.53463535
110MKNK20.53377973
111TIE10.53229295
112PTK2B0.52622801
113IRAK20.52213811
114MAPKAPK50.51641557
115ERBB20.50227515
116RPS6KA50.50104389
117OXSR10.49126628
118GRK50.47238308
119MAP3K130.46650001
120RAF10.46622866
121CSNK1E0.44984537
122CSNK1G10.44217316
123DYRK30.44027078
124CSNK1A10.43884756
125PLK30.42937358
126HIPK20.42617764
127CSNK1D0.40981558
128CAMK2D0.40940710
129AURKA0.40468811
130MYLK0.40459948
131FLT30.40158433
132ILK0.39275040
133SGK2230.38656102
134SGK4940.38656102
135AURKB0.38405567
136YES10.38028842
137ATM0.37738930
138BRSK10.37506517
139SRC0.37490518
140LATS10.35835830
141ACVR1B0.35242253
142IRAK10.34998331
143PRKD20.34679141
144CDK30.33312187
145MAP2K10.32646486
146TGFBR10.31462175
147LRRK20.31350817
148CAMK10.31068688

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.95365975
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64017160
3GABAergic synapse_Homo sapiens_hsa047272.22387515
4Steroid biosynthesis_Homo sapiens_hsa001002.21172731
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15995367
6Nitrogen metabolism_Homo sapiens_hsa009102.13861727
7Cocaine addiction_Homo sapiens_hsa050301.95366274
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93741773
9Glutamatergic synapse_Homo sapiens_hsa047241.89686114
10Circadian entrainment_Homo sapiens_hsa047131.88696632
11Amphetamine addiction_Homo sapiens_hsa050311.82808516
12Synaptic vesicle cycle_Homo sapiens_hsa047211.82261199
13Insulin secretion_Homo sapiens_hsa049111.75580603
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73908858
15Morphine addiction_Homo sapiens_hsa050321.73306797
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72338321
17Phototransduction_Homo sapiens_hsa047441.72210636
18Basal transcription factors_Homo sapiens_hsa030221.69073988
19Gastric acid secretion_Homo sapiens_hsa049711.68619430
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68537177
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67013985
22Fanconi anemia pathway_Homo sapiens_hsa034601.65700570
23Dopaminergic synapse_Homo sapiens_hsa047281.65366360
24Spliceosome_Homo sapiens_hsa030401.64433295
25Salivary secretion_Homo sapiens_hsa049701.61061398
26Propanoate metabolism_Homo sapiens_hsa006401.60458889
27Gap junction_Homo sapiens_hsa045401.58283567
28Long-term potentiation_Homo sapiens_hsa047201.58129127
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55684595
30Hedgehog signaling pathway_Homo sapiens_hsa043401.51293321
31Butanoate metabolism_Homo sapiens_hsa006501.50715578
32Melanogenesis_Homo sapiens_hsa049161.50006894
33Huntingtons disease_Homo sapiens_hsa050161.50000093
34Serotonergic synapse_Homo sapiens_hsa047261.47998352
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47658734
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47219171
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46772123
38Axon guidance_Homo sapiens_hsa043601.45389825
39Basal cell carcinoma_Homo sapiens_hsa052171.44935027
40RNA polymerase_Homo sapiens_hsa030201.42969482
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42026612
42RNA degradation_Homo sapiens_hsa030181.40274416
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39785137
44Selenocompound metabolism_Homo sapiens_hsa004501.39041635
45Homologous recombination_Homo sapiens_hsa034401.38644415
46Vibrio cholerae infection_Homo sapiens_hsa051101.34171080
47Renin secretion_Homo sapiens_hsa049241.33868384
48Olfactory transduction_Homo sapiens_hsa047401.31764030
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29448394
50Long-term depression_Homo sapiens_hsa047301.27997598
51RNA transport_Homo sapiens_hsa030131.27924885
52Mismatch repair_Homo sapiens_hsa034301.27170469
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27079355
54Cholinergic synapse_Homo sapiens_hsa047251.26607294
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24473846
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24071777
57Fatty acid biosynthesis_Homo sapiens_hsa000611.23667440
58Wnt signaling pathway_Homo sapiens_hsa043101.23574941
59Hippo signaling pathway_Homo sapiens_hsa043901.20099662
60Taste transduction_Homo sapiens_hsa047421.19305512
61Non-homologous end-joining_Homo sapiens_hsa034501.15234057
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.14247900
63Cardiac muscle contraction_Homo sapiens_hsa042601.13273611
64Dilated cardiomyopathy_Homo sapiens_hsa054141.12450299
65Ribosome_Homo sapiens_hsa030101.12178476
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11554090
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10179843
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09538919
69GnRH signaling pathway_Homo sapiens_hsa049121.08637766
70Nucleotide excision repair_Homo sapiens_hsa034201.08143372
71Base excision repair_Homo sapiens_hsa034101.07910960
72Oxytocin signaling pathway_Homo sapiens_hsa049211.07650015
73Calcium signaling pathway_Homo sapiens_hsa040201.07489234
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06702692
75ECM-receptor interaction_Homo sapiens_hsa045121.06070081
76Thyroid hormone synthesis_Homo sapiens_hsa049181.05254911
77TGF-beta signaling pathway_Homo sapiens_hsa043501.02485636
78Estrogen signaling pathway_Homo sapiens_hsa049151.01740406
79cAMP signaling pathway_Homo sapiens_hsa040241.00972819
80Cell cycle_Homo sapiens_hsa041100.99708137
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99584334
82mRNA surveillance pathway_Homo sapiens_hsa030150.96428231
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96200611
84DNA replication_Homo sapiens_hsa030300.95812558
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95593049
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95238619
87Protein export_Homo sapiens_hsa030600.94728773
88Pyruvate metabolism_Homo sapiens_hsa006200.94276972
89Oocyte meiosis_Homo sapiens_hsa041140.93195760
90N-Glycan biosynthesis_Homo sapiens_hsa005100.88762058
91Alcoholism_Homo sapiens_hsa050340.88307478
92Focal adhesion_Homo sapiens_hsa045100.88282039
93Sulfur relay system_Homo sapiens_hsa041220.87766390
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87737412
95Rap1 signaling pathway_Homo sapiens_hsa040150.86008630
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.85678100
97Fatty acid elongation_Homo sapiens_hsa000620.85531161
98Glioma_Homo sapiens_hsa052140.84460308
99Proteoglycans in cancer_Homo sapiens_hsa052050.84059428
100Dorso-ventral axis formation_Homo sapiens_hsa043200.83909353
101Proteasome_Homo sapiens_hsa030500.79295188
102Melanoma_Homo sapiens_hsa052180.79243030
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78309552
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78128905
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77731978
106Peroxisome_Homo sapiens_hsa041460.77269508
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77184939
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76559772
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.76422463
110Biosynthesis of amino acids_Homo sapiens_hsa012300.75727595
111Arginine and proline metabolism_Homo sapiens_hsa003300.74274399
112Type I diabetes mellitus_Homo sapiens_hsa049400.73778927
113Pyrimidine metabolism_Homo sapiens_hsa002400.72620353
114Circadian rhythm_Homo sapiens_hsa047100.72035424
115Parkinsons disease_Homo sapiens_hsa050120.71151195
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71043160
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71006572
118Oxidative phosphorylation_Homo sapiens_hsa001900.70822027
119Regulation of autophagy_Homo sapiens_hsa041400.69759626
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69757218
121Alzheimers disease_Homo sapiens_hsa050100.67963584
122Collecting duct acid secretion_Homo sapiens_hsa049660.66801401
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66785813
124Ether lipid metabolism_Homo sapiens_hsa005650.66525992
125ErbB signaling pathway_Homo sapiens_hsa040120.66423493
126Pancreatic secretion_Homo sapiens_hsa049720.65325133
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64004638
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63538448
129Linoleic acid metabolism_Homo sapiens_hsa005910.63216262
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62892749
131Folate biosynthesis_Homo sapiens_hsa007900.62716180
132Ras signaling pathway_Homo sapiens_hsa040140.62664223
133Colorectal cancer_Homo sapiens_hsa052100.62535759
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62497038
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62225244
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61934087
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60792588
138Metabolic pathways_Homo sapiens_hsa011000.60595224
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60355842
140beta-Alanine metabolism_Homo sapiens_hsa004100.60228661
141Choline metabolism in cancer_Homo sapiens_hsa052310.60072067
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.59998534
143Purine metabolism_Homo sapiens_hsa002300.59971056
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58622937
145One carbon pool by folate_Homo sapiens_hsa006700.56087968
146Protein digestion and absorption_Homo sapiens_hsa049740.55937521
147Bladder cancer_Homo sapiens_hsa052190.55565196
148Fatty acid metabolism_Homo sapiens_hsa012120.55545767
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55486330
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.54423384
151Tight junction_Homo sapiens_hsa045300.54131405
152MAPK signaling pathway_Homo sapiens_hsa040100.52487610
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52309575
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52200016
155Renal cell carcinoma_Homo sapiens_hsa052110.51801528
156Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51691036
157Pathways in cancer_Homo sapiens_hsa052000.50250396
158PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49632942
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48436606
160Tryptophan metabolism_Homo sapiens_hsa003800.44955675
161Carbon metabolism_Homo sapiens_hsa012000.44038092

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